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2.
Front Oncol ; 8: 127, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29755954

RESUMO

Background and objective: Diffuse intrinsic pontine glioma (DIPG) is a lethal brainstem tumor in children. Dendritic cells (DCs) have T-cell stimulatory capacity and, therefore, potential antitumor activity for disease control. DCs vaccines have been shown to reactivate tumor-specific T cells in both clinical and preclinical settings. We designed a phase Ib immunotherapy (IT) clinical trial with the use of autologous dendritic cells (ADCs) pulsed with an allogeneic tumors cell-lines lysate in patients with newly diagnosed DIPG after irradiation (radiation therapy). Methods: Nine patients with newly diagnosed DIPG met enrollment criteria. Autologous dendritic cell vaccines (ADCV) were prepared from monocytes obtained by leukapheresis. Five ADCV doses were administered intradermally during induction phase. In the absence of tumor progression, patients received three boosts of tumor lysate every 3 months during the maintenance phase. Results: Vaccine fabrication was feasible in all patients included in the study. Non-specific KLH (9/9 patients) and specific (8/9 patients) antitumor response was identified by immunologic studies in peripheral blood mononuclear cells (PBMC). Immunological responses were also confirmed in the T lymphocytes isolated from the cerebrospinal fluid (CSF) of two patients. Vaccine administration resulted safe in all patients treated with this schema. Conclusion: These preliminary results demonstrate that ADCV preparation is feasible, safe, and generate a DIPG-specific immune response detected in PBMC and CSF. This strategy shows a promising backbone for future schemas of combination IT.

4.
MEDICC Rev ; 18(3): 35-9, 2016 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-27510937

RESUMO

Gestational diabetes is the most common endocrine disorder affecting pregnant women and its prevalence is on the rise. Prevalence in Cuba is about 5.8%, and global prevalence ranges from 2% to 18% depending on the criteria applied. Gestational diabetes can lead to adverse gestational outcomes, such as fetal death, preterm delivery, dystocia, perinatal asphyxia and neonatal complications. Prompt, accurate diagnosis allowing early treatment can benefit both mother and child. The disease is asymptomatic, so clinical laboratory testing plays a key role in its screening and diagnosis. Cuba's approach to diabetes screening and diagnosis differs from some international practices. All pregnant women in Cuba are screened with a fasting plasma glucose test and diagnosed using modified WHO criteria. Some international recommendations are to skip the screening step and instead follow the diagnostic criteria of the Hyperglycemia and Adverse Pregnancy Outcomes study. In Cuba, gestational outcomes for women with diabetes (including gestational diabetes) are satisfactory (preeclampsia 5%; preterm delivery 12%; neonatal macrosomia 7.5%; congenital abnormalities 4.3% and perinatal deaths 4.8%). These data do not indicate a need to change established screening and diagnostic criteria. KEYWORDS Gestational diabetes, screening, diagnosis, early detection, early diagnosis, Cuba.


Assuntos
Diabetes Gestacional/diagnóstico , Programas de Rastreamento/métodos , Glicemia/análise , Cuba/epidemiologia , Diabetes Gestacional/epidemiologia , Diagnóstico Precoce , Feminino , Teste de Tolerância a Glucose , Política de Saúde , Humanos , Gravidez , Resultado da Gravidez , Prevalência
5.
Neurocir.-Soc. Luso-Esp. Neurocir ; 26(5): 234-240, sept.-oct. 2015. ilus
Artigo em Espanhol | IBECS | ID: ibc-142309

RESUMO

La prevalencia de los quistes aracnoideos en niños es del 1-3%. Son más frecuentes en el sexo masculino. Pueden localizarse tanto en el espacio intracraneal como a nivel espinal. Los intracraneales se clasifican en supratentoriales, infratentoriales y supra-infratentoriales. Los supratentoriales se subclasifican en de fosa media, hemisféricos de la convexidad, interhemisféricos, de la región selar e intraventriculares. Los infratentoriales se subdividen a su vez en supracerebelosos, infracerebelosos, hemisféricos, clivales y de ángulo pontocerebeloso. Por último, los espinales se clasifican según su localización extra o intradural y su afectación de raíces nerviosas (AU)


The prevalence of arachnoid cysts in children is 1-3%. They are more frequent in boys. They can be located intracranially or in the spine. Intracranial cysts are classified as supratentorial, infratentorial, and supra-infratentorial (tentorial notch). Supratentorial are divided into middle cranial fossa, convexity, inter-hemisferic, sellar region, and intraventricular. Infratentorial are classified into supracerebellar, infracerebellar, hemispheric, clivus, and cerebellopontine angle. Finally spinal arachnoid cysts are classified taking into account whether they are extra- or intradural, and nerve root involvement (AU)


Assuntos
Criança , Humanos , Cistos Aracnóideos/cirurgia , Procedimentos Neurocirúrgicos/métodos , Cistos Aracnóideos/classificação , Cistos do Sistema Nervoso Central/classificação , Espectroscopia de Ressonância Magnética
7.
Neurocirugia (Astur) ; 26(5): 234-40, 2015.
Artigo em Espanhol | MEDLINE | ID: mdl-25843209

RESUMO

The prevalence of arachnoid cysts in children is 1-3%. They are more frequent in boys. They can be located intracranially or in the spine. Intracranial cysts are classified as supratentorial, infratentorial, and supra-infratentorial (tentorial notch). Supratentorial are divided into middle cranial fossa, convexity, inter-hemisferic, sellar region, and intraventricular. Infratentorial are classified into supracerebellar, infracerebellar, hemispheric, clivus, and cerebellopontine angle. Finally spinal arachnoid cysts are classified taking into account whether they are extra- or intradural, and nerve root involvement.


Assuntos
Cistos Aracnóideos/classificação , Cistos Aracnóideos/epidemiologia , Encéfalo/patologia , Ângulo Cerebelopontino/patologia , Criança , Fossa Craniana Posterior/patologia , Humanos , Doenças da Medula Espinal/classificação , Doenças da Medula Espinal/epidemiologia
8.
MEDICC Rev ; 17(3): 27-32, 2015 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-26947155

RESUMO

INTRODUCTION Fetal macrosomia is the most important complication in infants of women with diabetes, whether preconceptional or gestational. Its occurrence is related to certain maternal and fetal conditions and negatively affects maternal and perinatal outcomes. The definitive diagnosis is made at birth if a newborn weighs >4000 g. OBJECTIVE Identify which maternal and fetal conditions could be macrosomia predictors in infants born to Cuban mothers with gestational diabetes. METHODS A case-control study comprising 236 women with gestational diabetes who bore live infants (118 with macrosomia and 118 without) was conducted in the América Arias University Maternity Hospital, Havana, Cuba, during 2002-2012. The dependent variable was macrosomia (birth weight >4000 g). Independent maternal variables included body mass index at pregnancy onset, overweight or obesity at pregnancy onset, gestational age at diabetes diagnosis, pregnancy weight gain, glycemic control, triglycerides and cholesterol. Fetal variables examined included third-semester fetal abdominal circumference, estimated fetal weight at ≥28 weeks (absolute and percentilized by Campbell and Wilkin, and Usher and McLean curves). Chi square was used to compare continuous variables (proportions) and the student t test (X ± SD) for categorical variables, with significance threshold set at p <0.05. ORs and their 95% CIs were calculated. RESULTS Significant differences between cases and controls were found in most variables studied, with the exception of late gestational diabetes diagnosis, total fasting cholesterol and hypercholesterolemia. The highest OR for macrosomia were for maternal hypertriglyceridemia (OR 4.80, CI 2.34-9.84), third-trimester fetal abdominal circumference >75th percentile (OR 7.54, CI 4.04-14.06), and estimated fetal weight >90th percentile by Campbell and Wilkin curves (OR 4.75, CI 1.42-15.84) and by Usher and McLean curves (OR 8.81, CI 4.25-18.26). CONCLUSIONS Most variables assessed were predictors of macrosomia in infants of mothers with gestational diabetes. They should therefore be taken into account for future studies and for patient management. Wide confidence intervals indicate uncertainty about the magnitude of predictive power. KEYWORDS Fetal macrosomia, fetal diseases, gestational diabetes, risk factors, risk prediction, Cuba.


Assuntos
Diabetes Gestacional , Macrossomia Fetal/etiologia , Adulto , Biomarcadores/sangue , Índice de Massa Corporal , Estudos de Casos e Controles , Cuba/epidemiologia , Feminino , Macrossomia Fetal/epidemiologia , Humanos , Lipídeos/sangue , Masculino , Valor Preditivo dos Testes , Gravidez , Estudos Retrospectivos , Fatores de Risco
9.
Childs Nerv Syst ; 29(8): 1321-31, 2013 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-23666431

RESUMO

PURPOSE: Pediatric brain stem tumors (BsT) are a heterogeneous group of diseases. Our aim was to analyze our experience to find out prognostic factors. METHOD: A retrospective study with BsT patients was performed. Imaging characteristics, extension of surgery, pathology, and adjuvant therapy were analyzed and correlated with overall survival (OS) and progression-free survival (PFS) as outcome measures. RESULT: Since 1980 to 2010, we analyzed 65 BsT patients, 41 of them girls (63%), median age of 8 years (range 13.9 months to 17.6 years). Twenty-two patients (33.8%) had diffuse intrinsic pontine gliomas (DIPG) and 43 (66.2%) presented with focal BsT. Histology was available in 42 patients; the most frequent is low-grade glioma in 24/42 patients (57%). DIPG's histology (obtained usually at necropsy) confirmed five high-grade gliomas. After median follow-up of 49.3 months (0.5-175 months), 20/22 DIPG patients have died (90.9%), while 27/43 with focal tumors were alive (62.8%). Variables related to outcome were histology (better for low-grade glioma (LGG) OS p < 0.001), surgery (better if operated OS p < 0.001), and adjuvant therapy (worse if given, PFS p = 0.001, OS p = 0.024). The outcome for DIPG was dismal, median OS/EFS of 14.2/9.4 months, significantly worse than focal BsT (p = 0.000), while OS/EFS was 122.8/87.2 months for focal intrinsic, 88.2/47.1 months for exophytic, and 124.4/54 months for cervico-medullary tumors: no differences were found among them, except the histology (OS p < 0.001 for low-grade vs high-grade tumors). CONCLUSION: BsT in children comprised two different groups: diffuse (DIPG) and focal gliomas. The DIPGs continue having a dismal prognosis, needing new approaches, while focal tumors including LGG have better prognosis.


Assuntos
Neoplasias do Tronco Encefálico/diagnóstico , Neoplasias do Tronco Encefálico/terapia , Adolescente , Idade de Início , Neoplasias do Tronco Encefálico/classificação , Neoplasias do Tronco Encefálico/complicações , Neoplasias do Tronco Encefálico/patologia , Criança , Pré-Escolar , Transtornos Cognitivos/etiologia , Terapia Combinada , Intervalo Livre de Doença , Feminino , Seguimentos , Humanos , Hidrocefalia/etiologia , Lactente , Imagem por Ressonância Magnética , Masculino , Complicações Pós-Operatórias , Estudos Retrospectivos
10.
Rev. cuba. obstet. ginecol ; 37(2): 172-181, Mayo-ago. 2011.
Artigo em Espanhol | LILACS | ID: lil-615196

RESUMO

INTRODUCCIÓN: El embarazo en la adolescencia ha sido asociado con problemas adversos para la salud. OBJETIVO: Identificar la morbimortalidad materna y perinatal en adolescentes con diabetes. MÉTODOS: Estudiamos retrospectivamente 138 embarazadas adolescentes (< 20 años) con diabetes. De ellas 101 eran diabéticas pregestacionales (B 2, C 64, D 30, F 1, R 3, y F-R 1 de Priscilla White) y 37 diabÚticas gestacionales (A1 24. A2 8 y A3 5 de Freinkel y Metzger). Comparamos los resultados maternos y perinatales con 242 adolescentes no diabéticas y 482 embarazadas no adolescentes y no diabéticas de la misma institución obtenidas al azar. Para el análisis de las variables se utilizó el test X2 de Fisher y Z para las proporciones, con un significado estadístico de p< 0,05. RESULTADOS: El grado de control metabólico fue calificado de "no óptimo" en el 42,0 por ciento de las diabéticas, lo cual pudo haber contribuido a la significativa mayor frecuencia de parto pretérmino, morbimortalidad perinatal y recién nacidos con peso = o > 4 000 g, esto último fue probablemente responsable de la mayor frecuencia de parto por cesárea. La frecuencia de malformaciones congénitas 11 (8,0 por ciento) resultó muy superior a lo reportado en nuestro país para población general e inclusive para gestantes diabéticas en el Servicio Central de Diabetes y Embarazo. CONCLUSIÓN: Los resultados perinatales adversos en las adolescentes diabéticas pudieron estar en relación, según nuestros resultados, con hiperglucemia de difícil control en estas gestantes y a la falta de asistencia a la consulta de control preconcepcional


INTRODUCTION: Pregnancy in adolescence has been associated with adverse health problems. OBJECTIVE: To identify the maternal and perinatal morbidity and mortality in adolescents presenting with diabetes. METHODS: A retrospective study was conducted in 138 adolescent pregnant patients (< 20 years) with diabetes. From them, 101 were pregestional diabetics (B2, C64, D30, F1, R3 and F-R 1 of Priscilla White) and 37 gestational diabetics (A1 24, A2 8 and A3-5 of Freinkel and Metzger). The maternal and perinatal results were compared to that of 242 non-diabetic adolescents and 482 non-adolescents pregnant and non-diabetics from the same institution at random. For variables' analysis the Fisher X2 test was used and Z for the ratios with a statistical significance of p< 0.05. RESULTS: The level of metabolic control was qualified as "non-optimal" in the 42.0 percent of the diabetics which may be contributed to the significant greater frequency of pre-term labor, morbidity and mortality and of newborns weighing = o > 4 000 g, it was probably the responsible of the greater frequency of cesarean section. The frequency of the eleven congenital malformations (8.0 percent was higher than the reported in our country for the general population and even for pregnants and to the non-attendance to pre-conception control consultation. CONCLUSION: The adverse perinatal results in diabetic adolescents could be in relation, according our results, to hyperglycemia of difficult control in these pregnants and to non-attendance to preconception control consultation


Assuntos
Humanos , Feminino , Gravidez , Adolescente , Complicações na Gravidez/prevenção & controle , Diabetes Gestacional/fisiopatologia , Gravidez em Diabéticas/metabolismo , Estudos de Casos e Controles , Estudos Retrospectivos
11.
Rev. cuba. obstet. ginecol ; 37(2): 172-181, Mayo-ago. 2011. tab
Artigo em Espanhol | CUMED | ID: cum-52290

RESUMO

INTRODUCCIÓN: El embarazo en la adolescencia ha sido asociado con problemas adversos para la salud. OBJETIVO: Identificar la morbimortalidad materna y perinatal en adolescentes con diabetes. MÉTODOS: Estudiamos retrospectivamente 138 embarazadas adolescentes (< 20 años) con diabetes. De ellas 101 eran diabéticas pregestacionales (B 2, C 64, D 30, F 1, R 3, y F-R 1 de Priscilla White) y 37 diabÚticas gestacionales (A1 24. A2 8 y A3 5 de Freinkel y Metzger). Comparamos los resultados maternos y perinatales con 242 adolescentes no diabéticas y 482 embarazadas no adolescentes y no diabéticas de la misma institución obtenidas al azar. Para el análisis de las variables se utilizó el test X2 de Fisher y Z para las proporciones, con un significado estadístico de p< 0,05. RESULTADOS: El grado de control metabólico fue calificado de "no óptimo" en el 42,0 por ciento de las diabéticas, lo cual pudo haber contribuido a la significativa mayor frecuencia de parto pretérmino, morbimortalidad perinatal y recién nacidos con peso = o > 4 000 g, esto último fue probablemente responsable de la mayor frecuencia de parto por cesárea. La frecuencia de malformaciones congénitas 11 (8,0 por ciento) resultó muy superior a lo reportado en nuestro país para población general e inclusive para gestantes diabéticas en el Servicio Central de Diabetes y Embarazo. CONCLUSIÓN: Los resultados perinatales adversos en las adolescentes diabéticas pudieron estar en relación, según nuestros resultados, con hiperglucemia de difícil control en estas gestantes y a la falta de asistencia a la consulta de control preconcepcional(AU)


INTRODUCTION: Pregnancy in adolescence has been associated with adverse health problems. OBJECTIVE: To identify the maternal and perinatal morbidity and mortality in adolescents presenting with diabetes. METHODS: A retrospective study was conducted in 138 adolescent pregnant patients (< 20 years) with diabetes. From them, 101 were pregestional diabetics (B2, C64, D30, F1, R3 and F-R 1 of Priscilla White) and 37 gestational diabetics (A1 24, A2 8 and A3-5 of Freinkel and Metzger). The maternal and perinatal results were compared to that of 242 non-diabetic adolescents and 482 non-adolescents pregnant and non-diabetics from the same institution at random. For variables' analysis the Fisher X2 test was used and Z for the ratios with a statistical significance of p< 0.05. RESULTS: The level of metabolic control was qualified as "non-optimal" in the 42.0 percent of the diabetics which may be contributed to the significant greater frequency of pre-term labor, morbidity and mortality and of newborns weighing = o > 4 000 g, it was probably the responsible of the greater frequency of cesarean section. The frequency of the eleven congenital malformations (8.0 percent was higher than the reported in our country for the general population and even for pregnants and to the non-attendance to pre-conception control consultation. CONCLUSION: The adverse perinatal results in diabetic adolescents could be in relation, according our results, to hyperglycemia of difficult control in these pregnants and to non-attendance to preconception control consultation(AU)


Assuntos
Humanos , Feminino , Gravidez , Adolescente , Complicações na Gravidez/prevenção & controle , Gravidez em Diabéticas/metabolismo , Diabetes Gestacional/fisiopatologia , Estudos de Casos e Controles , Estudos Retrospectivos
12.
Rev. cuba. endocrinol ; 22(1)ene.-abr. 2011.
Artigo em Espanhol | CUMED | ID: cum-49271

RESUMO

Se debe considerar a la diabetes gestacional (DG) como toda intolerancia a los carbohidratos que aparece o se reconoce durante el embarazo, independientemente del momento de la gestación al diagnóstico del trastorno metabólico, si se administra o no insulina, o si desaparece o no después del parto. Por ello, resulta un grupo heterogéneo de situaciones con diferentes expectativas y pronósticos, en dependencia del momento de su presentación y del grado de afectación metabólica que manifieste


Assuntos
Humanos , Feminino , Gravidez , Estado Pré-Diabético , Diabetes Gestacional
13.
Rev. cuba. endocrinol ; 22(1): 58-60, ene.-abr. 2011.
Artigo em Espanhol | LILACS | ID: lil-615037

RESUMO

Se debe considerar a la diabetes gestacional (DG) como toda intolerancia a los carbohidratos que aparece o se reconoce durante el embarazo, independientemente del momento de la gestación al diagnóstico del trastorno metabólico, si se administra o no insulina, o si desaparece o no después del parto. Por ello, resulta un grupo heterogéneo de situaciones con diferentes expectativas y pronósticos, en dependencia del momento de su presentación y del grado de afectación metabólica que manifieste...(AU)


Assuntos
Humanos , Feminino , Gravidez , Estado Pré-Diabético/epidemiologia , Fatores de Risco , Diabetes Gestacional/diagnóstico , Metabolismo dos Carboidratos/fisiologia
14.
Rev. centroam. obstet. ginecol ; 14(3): 99-104, jul.-sept. 2009.
Artigo em Espanhol | LILACS | ID: lil-733735

RESUMO

Objetivo: conocer las diferencias maternas y perinatales en gestantes con diagnóstico de Diabetes Gestacional realizado en la primera mitad del embarazo y aquellas en que el diagnóstico se realizó en la segunda mitad. Pacientes y métodos: estudiamos retrospectivamente 963 diabéticas gestacionales en el período 1992-2005. Las pacientes fueron diagnosticadas siguiendo las normas y criterios de la OMS. En 252 el diagnóstico se efectuó con 20 semanas o menos y en las restantes 711 después de las 20 semanas. Los factores de riesgo para intolerancia a la glucosa utilizados fueron los propuestos por Valdés Amador y cols en 1985...


Assuntos
Gravidez , Diabetes Gestacional/diagnóstico , Diabetes Gestacional/prevenção & controle , Intolerância à Glucose/diagnóstico , Fatores de Risco
15.
Rev. cuba. obstet. ginecol ; 34(3)sep.-dic. 2008. tab
Artigo em Espanhol | CUMED | ID: cum-37930

RESUMO

Objetivo: reportar la morbi-mortalidad perinatal y materna de este grado de intolerancia a la glucosa detectada durante el embarazo y que conjuntamente con el diagnóstico de Tolerancia a la Glucosa Alterada (TGA), se ha calificado de Prediabetes. Métodos: se estudiaron los resultados maternos y perinatales en 9 pacientes con resultado de la 2da. hora de la PTGo no patológica (menos de 7,8 mmo/L-140 mg/dL), pero que sí reunían criterios de Glucemia alterada en ayunas (GAA) según la OMS (6,1 a 6,9 mmol/L-110 a 125 mg/dL), en más de una ocasión. Resultados: en 4 de las pacientes fue necesario tratamiento con insulina regular humana Novonordisk a dosis que fluctuaron de 0,5 Ud/kg de peso corporal ideal a 1,6 Ud. El 50 por ciento de los RN presentaron exceso de peso corporal neonatal y 1 de ellos resultó superior a los 4 000 g, el cual desarrolló una hipoglucemia sintomática. Se detecta una anomalía congénita (Hidrocefalia), y 2 amenazas de parto pretérmino con necesidad de tratamiento anticálcico. Conclusión: la Glucemia alterada en ayunas (GAA) según nuestros resultados repercute severamente en la morbilidad materna y perinatal(AU)


Objective: to report the perinatal and maternal morbimortality corresponding to this degree of glucose intolerance detected during pregnancy and that together with the diagnosis of Impaired Glucose Tolerance (IGT) has been classified as Prediabetes. Methods: the maternal and perinatal results were studied in 9 patients with non-pathological respond at the second hour of the OGTT ( 7.8 mmol/L-140 mg/dL), but who fulfilled the criteria of impaired fasting glycaemia (IFG) according to the World Health Organization (6.1 to 6.9 mmol/L-110 to 125 mg/dL) more than once. RESULTS: in 4 of the patients it was necessary the treatment with Novonordisk human regular insulin at doses ranging from 0.5 Ud/kg of ideal body weight to 1.6 Ud. 50 percent of the newborn infants presented excess of neonatal body weight. One of them with a weight over 4 000 g developed a symptomatic hypoglycaemia. A congenital anomaly (hydrocepaly) and two menaces of pretem delivery with need of anticalcic treatment were detected. Conclusion: Impaired fasting glycaemia according to our results has a severe impact on maternal and perinatal morbidity(AU)


Assuntos
Humanos , Feminino , Gravidez , Teste de Tolerância a Glucose/efeitos adversos , Mortalidade Perinatal , Mortalidade Materna , Relatos de Casos
16.
Rev. cuba. obstet. ginecol ; 34(3)sept.-dic. 2008. tab
Artigo em Espanhol | LILACS | ID: lil-515655

RESUMO

Objetivo: reportar la morbi-mortalidad perinatal y materna de este grado de intolerancia a la glucosa detectada durante el embarazo y que conjuntamente con el diagnóstico de Tolerancia a la Glucosa Alterada (TGA), se ha calificado de Prediabetes. Métodos: se estudiaron los resultados maternos y perinatales en 9 pacientes con resultado de la 2da. hora de la PTGo no patológica (menos de 7,8 mmo/L-140 mg/dL), pero que sí reunían criterios de Glucemia alterada en ayunas (GAA) según la OMS (6,1 a 6,9 mmol/L-110 a 125 mg/dL), en más de una ocasión. Resultados: en 4 de las pacientes fue necesario tratamiento con insulina regular humana Novonordisk a dosis que fluctuaron de 0,5 Ud/kg de peso corporal ideal a 1,6 Ud. El 50 por ciento de los RN presentaron exceso de peso corporal neonatal y 1 de ellos resultó superior a los 4 000 g, el cual desarrolló una hipoglucemia sintomática. Se detecta una anomalía congénita (Hidrocefalia), y 2 amenazas de parto pretérmino con necesidad de tratamiento anticálcico. Conclusión: la Glucemia alterada en ayunas (GAA) según nuestros resultados repercute severamente en la morbilidad materna y perinatal.


Objective: to report the perinatal and maternal morbimortality corresponding to this degree of glucose intolerance detected during pregnancy and that together with the diagnosis of Impaired Glucose Tolerance (IGT) has been classified as Prediabetes. Methods: the maternal and perinatal results were studied in 9 patients with non-pathological respond at the second hour of the OGTT ( 7.8 mmol/L-140 mg/dL), but who fulfilled the criteria of impaired fasting glycaemia (IFG) according to the World Health Organization (6.1 to 6.9 mmol/L-110 to 125 mg/dL) more than once. RESULTS: in 4 of the patients it was necessary the treatment with Novonordisk human regular insulin at doses ranging from 0.5 Ud/kg of ideal body weight to 1.6 Ud. 50 percent of the newborn infants presented excess of neonatal body weight. One of them with a weight over 4 000 g developed a symptomatic hypoglycaemia. A congenital anomaly (hydrocepaly) and two menaces of pretem delivery with need of anticalcic treatment were detected. Conclusion: Impaired fasting glycaemia according to our results has a severe impact on maternal and perinatal morbidity.


Assuntos
Humanos , Feminino , Gravidez , Mortalidade Materna , Mortalidade Perinatal , Teste de Tolerância a Glucose/efeitos adversos , Relatos de Casos
17.
Rev. centroam. obstet. ginecol ; 13(3): 101-103, jul.-sept. 2008. ilus
Artigo em Espanhol | LILACS | ID: lil-644052

RESUMO

El objetivo de este trabajo es reportar la morbi-mortalidad perinatal y materna de este grado de intolerancia a la glucosa detectada durante el embarazo y que conjuntamente con el diagnóstico de Tolerancia a la Glucosa Alterada (TGA), se ha calificado de Prediabetes. Pacientes y Método: se estudian los resultados maternos y perinatales en 9 pacientes con resultados de 2 hora de PTGo no patológica (menos de 7,8mm/L-140 mg/dl), pero que si reunían criterios de GAA según la OMS (6,1 a 6,9 mmol/L-110 a 125 mg/dl), en más de una ocasión...


Assuntos
Humanos , Cuidado Pré-Natal/métodos , Diabetes Gestacional/diagnóstico , Glicemia/análise
18.
Rev. cuba. med. gen. integr ; 24(3)jul.-sep. 2008. tab
Artigo em Espanhol | CUMED | ID: cum-37393

RESUMO

Se realizó una investigación observacional analítica de tipo caso-control con el objetivo de determinar la frecuencia de la macrosomía neonatal, e identificar su relación con el grado de control metabólico, la edad gestacional a la que se diagnóstico la diabetes durante el embarazo, y el índice de masa corporal al inicio de la gestación, así como su repercusión en la morbilidad materna y perinatal en el embarazo complicado con diabetes. Se estudiaron 279 gestantes diabéticas (33 pregestacionales y 256 gestacionales) que fueron todas las que parieron un recién nacido vivo durante el período 2003-2006, cuando fueron atendidas en el Servicio de Diabetes y Embarazo del Hospital Ginecoobstétrico América Arias. La población fue dividida en 2 grandes grupos: las diabéticas que tuvieron un recién nacido macrosómico y las que no (261 y 28 gestantes, respectivamente). Se analizaron las variables siguientes: edad gestacional a la que se diagnosticó la diabetes (solo en las diabéticas gestacionales), índice de masa corporal al inicio del embarazo, grado de control metabólico, presencia de polihidramnios, tipo de parto, y Apgar del recién nacido al minuto y a los 5 min. La frecuencia de la macrosomía neonatal fue de 9,6 por ciento. El 25 por ciento de las gestantes diabéticas con hijos macrosómicos tuvieron un mal control metabólico, el 64,2 por ciento, sobrepeso corporal y el 10,7 polihidramnios, mientras que el 96,4 por ciento parió por cesárea. En el caso específico de las diabéticas gestacionales con hijos macrosómicos, en el 84 por ciento se diagnosticó tardíamente la enfermedad. No se encontró Apgar bajo en el grupo de los neonatos macrosómicos(AU)


An observational analytical case-control study was carried out aimed at determining the frequency of neonatal macrosomy and at identifying its connection with the metabolic control degree, gestational age at which diabetes mellitus was diagnosed, the body mass index at the beginning of gestation, as well as its impact on maternal and perinatal morbidity in pregnancy complicated with diabetes. 279 diabetic pregnants (33 pregestational and 256 gestational) were studied. All of them gave birth a live newborn from 2003 to 2006, when they received attention at the Service of Diabetes and Pregnancy of América Arias Gynecoobstetric Hospital. The population was divided into 2 big groups: the diabetics that had a macrosomic newborn and those who did not (261 and 28 pregnants, respectively). The following variables were analyzed: gestational age at which diabetes melitus was diagnosed (only among the pregnant diabetics), body mass index at the beginning of pregnancy, metabolic control degree, presence of polyhydramnios, type of delivery and Apgar score of the infant on the first minute and on the fifth minute. The frequency of neonatal macrosomy was 9.6 percent. 25 percent of the diabetic expectants with macrosomic offspring had a poor metabolic control, 64.2 percent were overweight, 10.7 percent had polyhidramnios, and 96.4 percent underwent cesarean. In the specific case of the gestational diabetics with macrosomic children, 84 percent were diagnosed late. No low Apgar score was found in the group of macrosomic neonates(AU)


Assuntos
Humanos , Feminino , Gravidez , Diabetes Gestacional , Gigantismo
19.
Rev. cuba. med. gen. integr ; 24(3)jul.-sept. 2008. tab
Artigo em Espanhol | LILACS | ID: lil-505437

RESUMO

Se realizó una investigación observacional analítica de tipo caso-control con el objetivo de determinar la frecuencia de la macrosomía neonatal, e identificar su relación con el grado de control metabólico, la edad gestacional a la que se diagnóstico la diabetes durante el embarazo, y el índice de masa corporal al inicio de la gestación, así como su repercusión en la morbilidad materna y perinatal en el embarazo complicado con diabetes. Se estudiaron 279 gestantes diabéticas (33 pregestacionales y 256 gestacionales) que fueron todas las que parieron un recién nacido vivo durante el período 2003-2006, cuando fueron atendidas en el Servicio de Diabetes y Embarazo del Hospital Ginecoobstétrico América Arias. La población fue dividida en 2 grandes grupos: las diabéticas que tuvieron un recién nacido macrosómico y las que no (261 y 28 gestantes, respectivamente). Se analizaron las variables siguientes: edad gestacional a la que se diagnosticó la diabetes (solo en las diabéticas gestacionales), índice de masa corporal al inicio del embarazo, grado de control metabólico, presencia de polihidramnios, tipo de parto, y Apgar del recién nacido al minuto y a los 5 min. La frecuencia de la macrosomía neonatal fue de 9,6 por ciento. El 25 por ciento de las gestantes diabéticas con hijos macrosómicos tuvieron un mal control metabólico, el 64,2 por ciento, sobrepeso corporal y el 10,7 polihidramnios, mientras que el 96,4 por ciento parió por cesárea. En el caso específico de las diabéticas gestacionales con hijos macrosómicos, en el 84 por ciento se diagnosticó tardíamente la enfermedad. No se encontró Apgar bajo en el grupo de los neonatos macrosómicos.


An observational analytical case-control study was carried out aimed at determining the frequency of neonatal macrosomy and at identifying its connection with the metabolic control degree, gestational age at which diabetes mellitus was diagnosed, the body mass index at the beginning of gestation, as well as its impact on maternal and perinatal morbidity in pregnancy complicated with diabetes. 279 diabetic pregnants (33 pregestational and 256 gestational) were studied. All of them gave birth a live newborn from 2003 to 2006, when they received attention at the Service of Diabetes and Pregnancy of América Arias Gynecoobstetric Hospital. The population was divided into 2 big groups: the diabetics that had a macrosomic newborn and those who did not (261 and 28 pregnants, respectively). The following variables were analyzed: gestational age at which diabetes melitus was diagnosed (only among the pregnant diabetics), body mass index at the beginning of pregnancy, metabolic control degree, presence of polyhydramnios, type of delivery and Apgar score of the infant on the first minute and on the fifth minute. The frequency of neonatal macrosomy was 9.6 percent. 25 percent of the diabetic expectants with macrosomic offspring had a poor metabolic control, 64.2 percent were overweight, 10.7 percent had polyhidramnios, and 96.4 percent underwent cesarean. In the specific case of the gestational diabetics with macrosomic children, 84 percent were diagnosed late. No low Apgar score was found in the group of macrosomic neonates.


Assuntos
Humanos , Feminino , Gravidez , Diabetes Gestacional , Gigantismo
20.
Rev. cuba. salud pública ; 33(4)oct.-dic. 2007.
Artigo em Espanhol | CUMED | ID: cum-35357

RESUMO

Se realizó una amplia revisión de los cuidados que debe recibir una mujer diabética antes de que decida embarazarse. Es necesario lograr un control metabólico adecuado previo a la gestación para evitar la aparición de malformaciones fetales, que pueden presentarse si existe hiperglicemia durante el período de embriogénesis del embarazo. También es importante precisar la existencia de complicaciones crónicas de la diabetes mellitus y su grado, dado que algunas deben ser corregidas antes del embarazo, o en dependencia de la severidad o del tipo, pudieran desaconsejarlo. Se hace imprescindible además, brindar orientación anticonceptiva a estas mujeres mientras esperan el momento más adecuado para enfrentar la gestación. En este trabajo se recogen las experiencias en relación con este tema y las pautas de acción en la consulta de Riesgo Materno Preconcepcional de la Mujer Diabética(AU)


An extensive literature review of the care that should be given to a diabetic woman before pregnancy was made. It is necessary to have an adequate metabolic control prior to gestation in order to avoid fetal malformation that may occur if hyperglycemia is present in the pregnancy embriogenesis term. It is similarly important to determine chronic complications of diatebes mellitus and their level of impact, given that some of these problems must be solved before pregnancy and, according to severity and type of the complication, a woman may even be advised against pregnancy. It is also essential to provide these women with contraceptive guidance while they are waiting for the most suitable time to get pregnant. This paper reflected the experience gained and the actions taken in the Pregestational Maternal Risk of the Diabetic Women medical consultation service(AU)


Assuntos
Gravidez em Diabéticas/prevenção & controle , Cuidado Pré-Concepcional/métodos
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