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1.
Anat Rec (Hoboken) ; 2020 Mar 05.
Artigo em Inglês | MEDLINE | ID: mdl-32134212

RESUMO

Therapeutic immobilization is a common treatment for the locomotor system; however, it causes loss of muscle due to disuse, leading to protein degradation and generating atrophy of muscle cells, ultimately changing functionality. In this sense, it is important for remobilization to be initiated early and performed with appropriate therapeutic strategies that enable tissue and functional recovery. One method of remobilization is physical exercise, among which whole body vibration (WBV) has been highlighted and mainly applied in people with reduced mobility. However, there are gaps on the morphological effects WBV has on muscle tissue, so in this study we analyzed the histomorphometry of the tibialis anterior muscle (TA) of Wistar rats remobilized using WBV. For the experiment, 32 male Wistar rats were used and divided into four groups (n = 8/group). Groups consisted of: control (CG), immobilized (IG), immobilized and remobilized freely (FG), and immobilized and remobilized with WBV (WG). After the experimental period, the TA was collected and processed for analysis in light microscopy. When compared to the control group, significant morphological changes were observed, which characterize muscle atrophy and reduction of all histomorphometric parameters of the TA of the immobilized animals. Remobilized animals showed improvement in all parameters, and the WBV was not different from the free remobilization, except for the reduction of central nuclei, which can be related to acceleration of the process of tissue regeneration. Thus, we can conclude that the WBV can have an impact on the acceleration of the muscle regenerative process, and may be beneficial in people with reduced mobility.

2.
Ecotoxicology ; 29(3): 314-326, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-32107698

RESUMO

Anthropogenic activities promote changes in community structure and decrease the species abundance of amphibians. The aim of this study was to assess potential alterations in the antioxidant system and cholinesterase activity, histopathological and oxidative damage in Lithobates catesbeianus tadpoles exposed to water from the Cascavel River, in Southern Brazil. Water samples (140 L each) were collected from the headwater, urban and rural areas of the river. Tadpoles were acclimated for seven days. After acclimatization tadpoles were reared in water from the river, except for the control aquarium. After seven days, a portion of the liver was removed and prepared for cholinesterase (ChE), superoxide dismutase (SOD), catalase (CAT) and lipid peroxidation (LPO) analysis; another part of the tissue was prepared for histological examination. An elevation of CAT activity was observed for water from both urban and rural environments. A decrease in LPO reaction was detected, mainly among the tadpoles exposed to water from the rural area. These alternations can cause delay the metamorphosis and lead to metabolic dysfunction, interfering in survival capacity and diminishing, not only individual fitness, but that of the whole population.


Assuntos
Antioxidantes/metabolismo , Colinesterases/metabolismo , Rana catesbeiana/fisiologia , Poluentes Químicos da Água/toxicidade , Animais , Brasil , Larva/fisiologia , Peroxidação de Lipídeos , Metamorfose Biológica/efeitos dos fármacos , Rios , Poluentes Químicos da Água/metabolismo
3.
Glob Pediatr Health ; 6: 2333794X19889243, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31799338

RESUMO

The present study characterized the plasma glycemic and lipid profiles in full-term newborn babies at birth and correlated these variables with growth markers and maternal clinical and metabolic conditions, to observe if maternal pregnancy conditions can influence metabolic programming in these newborn babies. Anthropometric and biochemical data were collected from 162 mother/newborn binomials at birth and at 6 months at a public hospital in Western Paraná State, Brazil. Samples of blood tests for glucose, insulin, total cholesterol, and triglycerides were obtained. Two classes of mothers/babies were statistically defined. The glycemic profiles in Class 1, at birth, were 63.0 ± 19.6 mg/dL and at 6 months 80.4 ± 10.6 mg/dL; in Class 2, at birth, they were 66.1 ± 20.8 mg/dL and at 6 months 78.2 ± 9.4 mg/dL. The triglycerides levels in Class 1 and Class 2, at birth, were 124.5 ± 47.8 mg/dL and 132.6 ± 60.2 mg/dL, respectively, and at 6 months they were 139.0 ± 51.5 mg/dL and 115.2 ± 39.9 mg/dL, respectively. Even though most of the pregnant women were overweight at the end of the gestation period, the anthropometric patterns found for babies followed the desirable standards. Furthermore, the average glycemic profile values were between the cutoff standards at birth and at 6 months; however, the triglycerides were above the expected values.

4.
Rev Bras Enferm ; 72(suppl 3): 3-8, 2019 Dec.
Artigo em Inglês, Português | MEDLINE | ID: mdl-31851228

RESUMO

OBJECTIVE: The present study evaluated the anthropometric and metabolic profiles of preterm infants (PT) born from mothers with urinary tract infections (UTI) and mothers with hypertensive disorders (HD). METHOD: This was a longitudinal prospective study conducted between May 2015 and August 2016. First, 59 mothers with premature birth were included; after excluding 29 mothers, two subgroups were created: UTI-mothers (n=12) and HD-mothers (n=18). The anthropometric and metabolic variables of mothers and their respective PT were analyzed at birth and at 6 months of corrected age (CA). RESULTS: Plasma triglyceride levels were higher among HD-mothers and their respective PT in comparison with UTI-mothers and their PT at 6 m of CA. CONCLUSION: Plasma triglyceride level is an important metabolic biomarker in HD-mothers resulting in higher triglyceride levels among PT at the CA of 6 m, suggesting an early programming effect of maternal hypertension.

5.
Clinics (Sao Paulo) ; 74: e629, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31508717

RESUMO

OBJECTIVE: How much force is needed to stretch skeletal muscle is still unknown. The aim of this study was to develop a device that mechanically stretches rat muscle to compare the force (N) required to stretch the soleus muscle of young and aged rats and the tibio-tarsal angle joint at neutral and stretched positions. METHODS: Twelve female Wistar rats were divided into two groups: a young group (YG, n=6, 311±11 g) of rats 3 months old and an aged group (AG, n=6, 351±43 g) of rats 15 months old. The left soleus muscle was mechanically held in full dorsal flexion and submitted to mechanical passive stretching: 1 bout of 10 repetitions, each repetition lasted 60 seconds with an interval of 45 seconds between repetitions, performed once a day, twice a week, for 1 week. The force required during stretching was measured by a load cell, and the tibio-tarsal angle joint was measured by photometry. RESULTS: The load cell calibration showed excellent reliability, as confirmed by the intraclass correlation coefficient value of 0.93. A decrease in delta force was found in the comparison between YG and AG (0.11±0.03 N vs 0.08±0.02 N, p<0.05, repeated measures ANOVA). There was no difference between the YG and the AG in the tibio-tarsal angle at resting position (87.1±3.8° vs 87.1±3.5°, p=0.35, Kruskal Wallis) and at the end of the stretching protocol (43.9±4.4° vs 42.6±3.4°, p=0.57, Kruskal Wallis). CONCLUSION: The device presented in this study is able to monitor the force necessary to stretch hindlimb rat muscles. Aged rats required less force than young rats to stretch the soleus muscle, and there was no difference regarding the tibio-tarsal angle between the two groups.


Assuntos
Exercícios de Alongamento Muscular/métodos , Músculo Esquelético/fisiologia , Animais , Fenômenos Biomecânicos , Peso Corporal , Modelos Animais de Doenças , Feminino , Ratos , Ratos Wistar
6.
Arq. bras. psicol. (Rio J. 2003) ; 71(1): 19-35, jan.-abr. 2019.
Artigo em Português | LILACS, Index Psicologia - Periódicos técnico-científicos | ID: biblio-1007205

RESUMO

Decorrente de eventos estressores na hospitalização, mães de recém-nascidos prematuros tornam-se vulneráveis para desenvolver a competência parental saudável. Objetivou-se comparar o nível de estresse de mães de recém-nascidos prematuros na hospitalização e após a alta hospitalar correlacionando-os aos níveis detectados na análise do conhecimento materno sobre os cuidados com o prematuro. Ensaio clínico randomizado, com mães de recém-nascidos prematuros hospitalizados em Unidade de Terapia Intensiva Neonatal, divididas em: Grupo de Intervenção-GI (atividades educativas) e Grupo Controle-GC (rotina). Mensurou-se o estresse materno pela Escala de Estresse Parental:UTIN (hospitalização) e Índice de Estresse Parental (após a alta hospitalar). Níveis de estresse do GI diminuíram 2,68 vezes em relação ao GC após a alta, contudo sem significância estatística quanto ao conhecimento materno entre os grupos. Para prevenir o estresse após a alta, em mães de prematuros, deve-se empoderá-las para cuidarem do filho


Mothers of preterm infants suffer stressful events during the hospitalization, making them vulnerable for not developing healthy parental competence. This study aimed to compare the stress level of mothers of preterm infants at hospital admission and after discharge, correlating them with the levels detected in the analysis of maternal knowledge about premature infants' care. This was a randomized clinical trial. Mothers of premature infants hospitalized in Neonatal Intensive Care Unit were divided in Intervention Group-IG (educative activities) and Control Group-CG (routine). Stress levels were measured by Parental Stress Scale:NICU (hospitalization) and Parental Stress Index (after hospital discharge). The stress levels of mothers that participated in IG decreased 2.68 times compared to CG after discharge; however, there was no statistical significance in the knowledge between the groups. Preventing stress after discharge in mothers of preterm infant requires empowering them to take care of their children


A raíz de acontecimientos estresantes en la hospitalización, las madres de recién nacidos prematuros se vuelven vulnerables para desarrollar la competencia parental saludable. Se objetivó comparar el nivel de estrés de madres de recién nacidos prematuros en la hospitalización y después del alta hospitalaria correlacionándolos a los niveles detectados en el análisis del conocimiento materno sobre los cuidados con el prematuro. En el estudio clínico aleatorizado, con madres de recién nacidos prematuros hospitalizados en Unidad de Terapia Intensiva Neonatal, divididas en: Grupo de Intervención-GI (actividades educativas) y Grupo Control-GC (rutina). Se midió el estrés materno por la Escala de estrés parental: UTIN (hospitalización) e índice de estrés parental (después del alta hospitalaria). Los niveles de estrés del GI disminuyeron 2,68 veces en relación con el GC después del alta, pero sin significancia estadística en cuanto al conocimiento materno entre los grupos. Para prevenir el estrés después del alta, en madres de prematuros, se deben empoderarlas para cuidar del hijo


Assuntos
Humanos , Feminino , Recém-Nascido , Estresse Psicológico , Recém-Nascido Prematuro , Mães
7.
Environ Pollut ; 249: 82-90, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-30878865

RESUMO

Due to increased use of agrochemicals and growing concerns about ecotoxicology, the development of new insecticides, moving away from those with neurotoxic and broad spectrum effects towards insecticides that are safer for the environment and nontarget beneficial species, has been a research priority. Novaluron stands out among these newer insecticides, is an insect growth regulator that is used for the control of insect pests in crops grown close to mulberry plantations. Mulberry serves as food for the silkworm Bombyx mori, which is a nontarget insect of great economic importance to silk production. We investigated the lethal and sublethal effects of Novaluron on the development of B. mori. Larvae were segregated into experimental groups: the control groups (CGs) and the treatment groups (TGs), which were treated with the Novaluron concentration of 0.15 mL/L. Following exposure, we analyzed: larval mortality, changes in the insect life cicle and cytotoxic effects on the midgut cells. This is the first report about the Novaluron's effects on B.mori. We detected rupture in the integument, complete cessation of feeding, late development, incomplete ecdysis and production of defective cocoons. After 240 h of exposure, there was 100% mortality in TG larvae exposed in the 3rd instar and 20% mortality from larvae exposed in the 5th instar. Cytotoxic effects was observed, such as dilation of cells, emission of cytoplasmic protrusions, extreme rarefaction of the cytoplasm and nuclei, dilation of the endoplasmic reticulum in addition to changes in mitochondria, the presence of large digestive vacuoles and intercellular spaces and the presence of active caspase. Novaluron exposure impairs the midgut and may affect the physiological functions of this organ. Novaluron additionally compromises several phases of insect development, indicating the importance of toxicology studies that utilize different life stages of nontarget species to evaluate the safe use of insecticides.


Assuntos
Bombyx/fisiologia , Inseticidas/toxicidade , Compostos de Fenilureia/toxicidade , Animais , Bombyx/efeitos dos fármacos , Larva/efeitos dos fármacos , Lepidópteros , Manduca , Morus
8.
Sci Total Environ ; 667: 371-383, 2019 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-30831371

RESUMO

This study aimed to assess the water quality of the Perequê River, Porto Belo, Santa Catarina, Brazil, through a biomarker approach in the native fish species Geophagus brasiliensis, and the sediment chemical quantification of the herbicides glyphosate and bentazone used in irrigated rice plantations. This river is used for the public water supply of two municipalities. The first sampling (S1) was in November 2016, in the spring season and the second (S2), in March 2017, in the fall season. In each sampling, two points of the river were analyzed, one upstream of the accumulation dam and the water catchment point for water supply of the Porto Belo WTS (P1), and another downstream (P2) with water, sediment, and fish sampling. Biotransformation, oxidative stress, histopathological and genotoxic biomarkers were analyzed in different tissues. The presence of glyphosate was detected in the sediment (11.7 µg·kg-1) from the upstream point of the water catchment site (P1) in spring. The lower activity of the antioxidant enzyme superoxide dismutase (SOD), as well as the increased damage to renal DNA and hepatic tissue, coincided with the lower muscular and cerebral acetylcholinesterase activities (AChE) at P1, in relation to P2 in the spring season, with a lower rainfall index (81.8 mm3). A seasonal variation was also observed between the spring and fall seasons, in fish responses to biomarkers. Reduction of muscle AChE activity and biotransformation enzymes ethoxyresorufin-O-deethylase and glutathione S-transferase and antioxidant enzymes such as, SOD and glutathione peroxidase, as well as increased brain DNA damage, coincided with the highest number of tissue lesions in the liver and gills in the spring, regardless of the sampling point. The results suggested that the Perequê River is contaminated by xenobiotics and probably herbicides from irrigated rice plantations, indicating damages to the biota and a potential public health risk.


Assuntos
Ciclídeos/fisiologia , Monitoramento Ambiental/métodos , Poluentes Químicos da Água/toxicidade , Animais , Biomarcadores/metabolismo , Brasil , Citocromo P-450 CYP1A1/metabolismo , Glutationa Peroxidase/metabolismo , Glutationa Transferase/metabolismo , Rios/química , Superóxido Dismutase/metabolismo
9.
Acta Trop ; 192: 158-164, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-30660751

RESUMO

Lonomia obliqua Walker 1855 (Lepidoptera: Saturniidae) is a species of moth which larvae are responsible for the lonomism, a form of envenomation that has been occurring in Brazil since the 1980s. Despite the importance in public health, the geographical distribution and their ecological aspects are unknown. Therefore, in the present study, we present a potential geographical distribution map for L. obliqua in Brazil, based on the combination of different Ecology Niche Modelling (ENM) algorithms. A total of 38 occurrence points were distributed in the southern/ southeastern regions of Brazil and in the province of Misiones (Argentina), which were divided for calibration and evaluation of the model. Eight continuous climatic and soil variables were selected from 16 previously calculated for model calibration. The final model-map is composed of a combination of four algorithms (Gower, Mahalanobis, MAXENT and SVM), with samples of pseudo-absences outside a Bioclimatic Envelope (BIOCLIM) in quantity equal to the presences. This model-map was binarized from the Low Presence Threshold (LPT) and cut only to the Brazilian area. According to this map, the areas predicted as suitable for L. obliqua are restricted between latitudes ˜12° and ˜32°, and longitudes ˜39° and ˜57°, with extension of 1,181,604 km². The model-map was also validated with external data from samples of the species, at municipality level, in the state of Rio Grande do Sul (Brazil). From this information, we extracted the values of variables related to climate and soil, and with additional variables related to the land use and type of vegetation, in order to contribute to the ecological knowledge of the species. In general, the map and the ecological information obtained can serve as a tool for public health agents in Brazil to adequately guide preventive strategies and attention to lonomism in the country, and with addendum on habitat loss and accident conditions with the species.


Assuntos
Ecologia , Ecossistema , Geografia , Larva/anatomia & histologia , Lepidópteros , Mariposas , Distribuição Animal , Animais , Brasil
10.
Clinics ; 74: e629, 2019. tab, graf
Artigo em Inglês | LILACS-Express | ID: biblio-1019710

RESUMO

OBJECTIVE: How much force is needed to stretch skeletal muscle is still unknown. The aim of this study was to develop a device that mechanically stretches rat muscle to compare the force (N) required to stretch the soleus muscle of young and aged rats and the tibio-tarsal angle joint at neutral and stretched positions. METHODS: Twelve female Wistar rats were divided into two groups: a young group (YG, n=6, 311±11 g) of rats 3 months old and an aged group (AG, n=6, 351±43 g) of rats 15 months old. The left soleus muscle was mechanically held in full dorsal flexion and submitted to mechanical passive stretching: 1 bout of 10 repetitions, each repetition lasted 60 seconds with an interval of 45 seconds between repetitions, performed once a day, twice a week, for 1 week. The force required during stretching was measured by a load cell, and the tibio-tarsal angle joint was measured by photometry. RESULTS: The load cell calibration showed excellent reliability, as confirmed by the intraclass correlation coefficient value of 0.93. A decrease in delta force was found in the comparison between YG and AG (0.11±0.03 N vs 0.08±0.02 N, p<0.05, repeated measures ANOVA). There was no difference between the YG and the AG in the tibio-tarsal angle at resting position (87.1±3.8° vs 87.1±3.5°, p=0.35, Kruskal Wallis) and at the end of the stretching protocol (43.9±4.4° vs 42.6±3.4°, p=0.57, Kruskal Wallis). CONCLUSION: The device presented in this study is able to monitor the force necessary to stretch hindlimb rat muscles. Aged rats required less force than young rats to stretch the soleus muscle, and there was no difference regarding the tibio-tarsal angle between the two groups.

11.
Fisioter. Pesqui. (Online) ; 25(4): 382-387, out.-dez. 2018. graf
Artigo em Português | LILACS-Express | ID: biblio-975353

RESUMO

RESUMO Esta pesquisa teve como objetivo identificar os principais efeitos adversos observados por fisioterapeutas com o uso de aparelhos de eletrotermofototerapia em clínicas da cidade de Cascavel, Paraná. A amostra contou com 35 clínicas e destas, 25 foram alvo de coleta após triagem, cujos dados foram obtidos por questionários em forma de entrevista semiestruturada. Nestes se questionava aos responsáveis pelo serviço de eletrotermofototerapia sobre a ocorrência de efeitos adversos experienciados durante atividades laborais na clínica. Observou-se que a Neuroestimulação Elétrica Transcutânea (TENS) apresentou problemas em 64% dos casos, com 36% devido a irritações cutâneas e 28% a dor. O aparelho de ondas curtas apresentou efeitos adversos em 60%, em que 40% foram queixas de dor e 20% causaram queimaduras leves. Já acerca do ultrassom terapêutico foram relatados efeitos adversos em 52%, sendo 32% de quadros de dor e 20% de casos com náuseas. A laserterapia de baixa potência demonstrou efeito adverso em 36%, com relatos de aumento da sensibilidade local. Por fim, os aparelhos de média frequência apresentaram efeitos adversos em apenas 20% dos casos, de queixas de náuseas. A quantidade de tais efeitos encontrados foi importante, porém sua gravidade não causou grande preocupação.


RESUMEN Este estudio propone identificar los principales efectos adversos observados por fisioterapeutas con el uso de aparatos de electrotermofototerapia en clínicas de la ciudad de Cascavel, Paraná (Brasil). De la muestra han participado 35 clínicas, de las cuales restaron 25 después del triaje, cuyos datos fueron obtenidos por cuestionarios en forma de entrevista semiestructurada. Estos contenían preguntas al responsable del servicio de electrotermofototerapia sobre la ocurrencia de los efectos adversos ocurridos durante el trabajo en la clínica. Se observó que el Electroestimulación Transcutánea (TENS, en inglés) presentó problemas en un 64 % de los casos, con un 36 % debido a irritaciones de la piel y un 28 % al dolor. En el aparato de ondas cortas se verificó efectos adversos en un 60 %, de las cuales un 40 % fueron de quejas de dolor y un 20 % de quemaduras leves. Sobre el ultrasonido terapéutico, se han divulgado los efectos adversos en un 52 %, de los cuales un 32 % fueron síntomas de dolor y un 20 % casos con náuseas. La terapia con láser de baja intensidad resultó en efectos adversos en el 36 %, con informes de aumento de la sensibilidad local. Por último, los dispositivos de frecuencia media revelaron efectos adversos en sólo el 20 % de los casos de las quejas de náuseas. La cantidad de estos efectos encontrados es importante, pero su gravedad no demostró gran preocupación.


ABSTRACT This study aimed to identify the main adverse effects observed by physical therapists using electrothermal phototherapy devices in clinics in the city of Cascavel, Paraná. The sample comprised 35 clinics, of which 25 were submitted to data collection after sorting. Data were collected through questionnaires in the form of semi-structured interview. In these questionnaires, the responsible for providing the electrothermal phototherapy service were asked about the occurrence of adverse effects experienced during labor activities at the clinic. Transcutaneous electrical nerve stimulation (TENS) showed problems in 64% of cases, being 36% due to skin irritations and 28% due to pain. The shortwave apparatus showed adverse effects in 60% of cases, of which 40% consisted of complaints of pain and 20% caused minor burns. Regarding therapeutic ultrasound, adverse effects were reported in 52% of cases, of which 32% were episodes of pain and 20% of nausea. The low-power laser therapy showed adverse effect on 36% of cases, with reports of increased local sensitivity. Finally, the medium frequency devices had adverse effect in only 20% of cases, being complaints of nausea. The amount of such effects found was important, but their gravity did not cause major concern.

12.
Rejuvenation Res ; 21(6): 518-526, 2018 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-29669458

RESUMO

The aim of this study was to evaluate the effects of a pop dance exergaming protocol on fall risk factors-depressive symptoms, fear of falling, and musculoskeletal function-in community-dwelling older female fallers and nonfallers. There were 47 community-dwelling older women assigned to the intervention group (IG) [fallers (n = 10, 69.8 ± 4.3 years); nonfallers (n = 12, 68.9 ± 3.3 years)] and the control group (CG) [fallers (n = 12, 73.6 ± 5.4 years); nonfallers (n = 13, 68.7 ± 4.8 years)]. The CG maintained their lifestyle and the IG performed a videogame dance training three times per week for 12 weeks. The Dance Central game for Xbox 360® and Kinect motion sensor were used. The primary outcomes were geriatric depressive symptoms, fear of falling, and concentric and eccentric isokinetic peak torque (PT) of quadriceps and hamstrings. Secondary outcomes included cross-sectional area of quadriceps and hamstring muscles, functionality (Timed Up and Go test, gait speed, the Five Times Sit-to-Stand test), and a fall circumstances and outcomes recording. The depressive symptoms decreased in the Intervention Fallers Group. The eccentric hamstrings PT at 180°/s increased in the Intervention Nonfallers Group. There were no significant differences between groups for the other variables analyzed. The training attendance was 83% for the Intervention Fallers Group and 88% for the Intervention Nonfallers Group. Dance exergaming can be indicated to decrease depressive symptoms in fallers and increase the PT in nonfallers among community-dwelling older women.


Assuntos
Acidentes por Quedas/prevenção & controle , Dança/fisiologia , Depressão/terapia , Exercício/fisiologia , Medo/psicologia , Vida Independente , Doenças Musculoesqueléticas/terapia , Acidentes por Quedas/estatística & dados numéricos , Idoso , Estudos de Casos e Controles , Estudos Transversais , Depressão/psicologia , Feminino , Humanos , Masculino , Doenças Musculoesqueléticas/psicologia , Projetos Piloto , Equilíbrio Postural , Fatores de Risco , Jogos de Vídeo
13.
Ecotoxicol Environ Saf ; 155: 162-170, 2018 Jul 15.
Artigo em Inglês | MEDLINE | ID: mdl-29522881

RESUMO

The use of multiple biomarkers has been shown to be an efficient method for evaluating environmental contamination. In this work, we evaluate neurotoxic effects and the antioxidant system responses of the R. branneri collected in two streams of lower Iguazu River basin, relating them with different percentage of vegetation coverture, presence of pesticides and fall and winter seasons. The biological samples were collected in March and August of 2015, from two streams that belong to the lower Iguazu River basin (Brazil): the Manoel Gomes River and the Arquimedes Stream. Soil analyses were performed, and the results showed the presence of the following organophosphates in the Manoel Gomes River and the Arquimedes Stream: disulfoton, methyl parathion, and ronnel. The present study detected inhibition of cholinesterase activity in the brain and muscle of fish samples during the fall from the Manoel Gomes River and the Arquimedes Stream. In the Manoel Gomes River, elevated lipoperoxidation was also observed during the fall. It was observed that the increase or decrease of biomarkers was related to temporal variation and, possibly, to the exposure of animals to agrochemicals. Although the Manoel Gomes River and the Arquimedes Stream are located in regions with large areas of vegetation, the soil analyses show that agrochemical residues are able to reach these locations, which suggests that the fauna are in contact with oxidant and anti-cholinesterase agents during the fall, in addition to respond differently during each season.


Assuntos
Peixes-Gato/metabolismo , Inibidores da Colinesterase/toxicidade , Organofosfatos/toxicidade , Praguicidas/toxicidade , Poluentes Químicos da Água/toxicidade , Animais , Biomarcadores/metabolismo , Encéfalo/efeitos dos fármacos , Encéfalo/enzimologia , Brasil , Colinesterases/metabolismo , Monitoramento Ambiental/métodos , Músculos/efeitos dos fármacos , Músculos/enzimologia , Rios , Estações do Ano
14.
Motriz (Online) ; 24(2): e101868, 2018. tab, graf
Artigo em Inglês | LILACS-Express | ID: biblio-955140

RESUMO

Abstract AIMS the purpose of this study was to assess the effects of a supervised dance intervention based on video game choreography on isokinetic concentric and eccentric knee peak of torque (PT), quadriceps and hamstrings cross sectional area (CSA) and functionality in community-dwelling older women. METHODS Forty-seven older women were allocated in Control Group (CG, n=25) and Intervention Group (IG, n=22). The IG performed dance based on video game choreography (Dance Central, XBOX 360®, Kinect), during 12 weeks, ~40 minutes, 3x/week, without foam (1-6week) and with foam and visual disturbances (7-12 week). The pretest-training-posttest assessments included: isokinetic concentric and eccentric knee PT and CSA (Magnetic resonance imaging) of quadriceps and hamstrings and functional tests. RESULTS The light-to-moderate-intensity 12-weeks training increased 8.5% the eccentric PT of quadriceps at 60°/s (p=0.04) and 1.3% quadriceps CSA (p=0.02). CONCLUSIONS These findings suggest that dance training based on video game choreography can enhance PT and induce hypertrophy in community-dwelling older women.

15.
Fisioter. Mov. (Online) ; 30(3): 537-547, July-Sept. 2017. tab, graf
Artigo em Inglês | LILACS-Express | ID: biblio-891996

RESUMO

Abstract Introduction: Diplegic children have difficulties in gait and therefore ramps are used as strategies of accessibility. Objective: The present study investigated the influence of an inclined surface (ascending and descending) on the kinematic characteristics during gait of the diplegic group (DG) when compared to typically developing children of the control group (CG). Methods: Study participants included 20 children (10 with DG and 10 CG) matched by age, which were evaluated in three experimental conditions (horizontal and inclined ascending and inclined descending surfaces of 7º) through an optoelectronic imaging system. Results: Among the linear kinematic variables, only step width differed among groups, however, without influence of the surface. The foot height differed among the groups only in the descending phase, where DG had greater difficulty in raising the foot. The 3-dimensional gait analyses could not provide more evidences of differences in kinematics variables, especially in transverse plane, between DG and CG, but provide some evidence to support that hip range of motion (ROM) during the gait cycle, hip flexion-extension in initial contact, knee ROM and the 2nd anterior-posterior trunk peak amplitude of the DG were influenced on descent by their flexor pattern. Conclusion: The DG was most affected by the inclination plane than CG especially on descent. Although a hip and knee flexor pattern is evident for DG on inclination of 7º, this angle is accessible since it allows independent gait functional activity.


Resumo Introdução: Crianças com diplegia apresentam dificuldades na marcha e rampas são utilizadas como estratégia de acessibilidade. Objetivo: O presente estudo investigou a influência da superfície inclinada (subida e descida) sobre as variáveis cinemáticas durante a marcha no grupo com diplegia (GD) comparado ao grupo de crianças com desenvolvimento típico no grupo controle (GC). Métodos: Participaram do estudo 20 crianças (10 GD e 10 GC) pareadas por idade, as quais foram avaliadas em 3 condições experimentais (horizontal, subida e descida de 7º) por meio de um sistema de imagem optoeletrônico. Resultados: Nas variáveis cinemáticas lineares apenas o comprimento do passo diferiu entre os grupos sem influência da inclinação do plano. A altura do pé diferiu entre os grupos na descida, com maior dificuldade do GD em elevar o pé. A análise tridimensional da marcha não permitiu identificar diferenças cinemáticas no plano transverso entre GD e GC, mas identificou que a ADM de quadril durante o ciclo de marcha, flexo-extensão de joelho no contato inicial, ADM de joelho e o 2º pico de amplitude de movimento (ADM) ântero-posterior de tronco do GD foram influenciadas na descida devido ao padrão flexor desse grupo. Conclusão: O GD foi mais afetado que o GC, especialmente na descida. Embora sejam evidenciados padrões de flexão de quadril e joelhos do GD na inclinação de 7º, essa angulação é acessível ao permitir marcha funcional independente.

16.
Arch Oral Biol ; 82: 79-85, 2017 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-28622548

RESUMO

OBJECTIVE: To evaluate early bony changes in an animal model of Medication-Related Osteonecrosis of the Jaw (MRONJ) at the side of the local trauma and at the contralateral side, comparing with a control group. Bony changes were evaluated by Microcomputed Tomography (MicroCT) at three times points: at baseline (T0), after drug administration (T1) and after dental extraction (T2). DESIGN: Two groups were compared: the experimental group in which zoledronic acid (ZA) was administered (17 rats) and the control group (13 rats). Dental extractions of the lower left first molars were performed in all animals. The left side was considered as the supposed affected area in the ZA group, and the right side was considered as the unaffected area. In these areas, the following structural microtomographic bone parameters were calculated: Bone Mineral Density (BMD), Trabecular Thickness (Tb.Th), and Bone Volume Proportion (BV/TV). The comparison of quantitative bone parameters among the different sides and experimental phases of both studied groups were performed by ANOVA-factorial. RESULTS: None of the animals of the control group developed MRONJ. In the ZA group, 76% presented bone exposure. From T0 to T1, Tb.Th and BV/TV increased, and in T2, the mean values were higher in ZA group than in the control group. BMD increased throughout the different phases of both groups. CONCLUSIONS: Structural bony changes occurred in the ZA group at both mandibular sides before the dental extraction (T1). Tb.Th and BV/TV should be further investigated as potential early bone markers of MRONJ.


Assuntos
Osteonecrose da Arcada Osseodentária Associada a Difosfonatos/patologia , Difosfonatos/toxicidade , Imidazóis/toxicidade , Animais , Osteonecrose da Arcada Osseodentária Associada a Difosfonatos/diagnóstico por imagem , Modelos Animais de Doenças , Estudos Longitudinais , Dente Molar/diagnóstico por imagem , Dente Molar/cirurgia , Ratos , Extração Dentária , Microtomografia por Raio-X , Ácido Zoledrônico
17.
Bull Environ Contam Toxicol ; 99(2): 232-238, 2017 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-28516254

RESUMO

Cholinesterase (ChE) activity was measured in Astyanax bifasciatus maintained in controlled conditions. Muscle ChE activity of individuals collected in field conditions in two seasons was compared among specimens collected in seven streams (forest and rural) of the lower Iguaçu river basin in association with physical, chemical, pesticides and biological factors. Significant differences in muscle ChE activity between control fish and fish collected in streams in both seasons were found, with higher activity in natural conditions. This the first time that differences in muscle ChE activity have been found among fish collected from different streams, suggesting synergism among multiple factors (e.g. temperature, pH, animal weight) and ecological attributes (richness and abundance) as influencing the variation in biomarkers. It is necessary to evaluate the quality of aquatic environments for a more accurate biomonitoring approach.


Assuntos
Characidae/metabolismo , Colinesterases/metabolismo , Monitoramento Ambiental , Animais , Biomarcadores/metabolismo , Músculos/metabolismo , Praguicidas/análise , Praguicidas/toxicidade , Rios/química , Estações do Ano , Poluentes Químicos da Água/análise , Poluentes Químicos da Água/toxicidade
18.
Chemosphere ; 182: 267-275, 2017 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-28500971

RESUMO

The aim of this work was to investigate the effects of glyphosate on the antioxidant system, as well as the neurotoxic effects on the larvae of Rhamdia quelen. A completely randomized design was implemented with the eggs of silver catfish distributed in 48 containers with 300 mL of water, which were subdivided randomly into two groups: control and treated with 6.5 mg L of glyphosate. These groups were evaluated at four time points (12 h, 24 h, 48 h, and 72 h), each with six replications. The survival rate of eggs/larvae (%) was evaluated, and samples were collected for antioxidant system analysis (catalase - CAT, glutathione transferase - GST, glutathione reductase - GR, and lipoperoxidation - LPO), and neurotoxic evaluation (cholinesterase - ChE). Throughout the 72 h of experimentation, there was a higher survival rate among the animals treated with glyphosate. The highest value of integrated biomarkers response (IBR = 1.26) was at 12 h, presenting induction of the cholinesterase (ChE) enzyme and GR. At 24 h, the value of IBR was -2.56, with inhibition of ChE and induction of GR. At 48 h, the value was -0.76, with induction of LPO. The lowest value of IBR was at 72 h (-4.65), with induction of GST and inhibition of all other biomarkers. Finally, it was possible to detect an acute effect of glyphosate throughout the early development of R. quelen, with a decrease in the antioxidant system control and neurotoxic effects.


Assuntos
Peixes-Gato , Glicina/análogos & derivados , Larva/efeitos dos fármacos , Praguicidas/toxicidade , Animais , Antioxidantes/análise , Antioxidantes/farmacologia , Biomarcadores/metabolismo , Catalase/metabolismo , Colinesterases/metabolismo , Glutationa Redutase/metabolismo , Glutationa Transferase/metabolismo , Glicina/farmacologia , Larva/metabolismo , Neurotoxinas/farmacologia , Oxirredução , Praguicidas/química , Taxa de Sobrevida , Poluentes Químicos da Água/toxicidade
19.
Rev. bras. cineantropom. desempenho hum ; 19(2): 150-163, Mar.-Apr. 2017. tab, graf
Artigo em Inglês | LILACS | ID: biblio-843435

RESUMO

Abstract The human being does not have static development throughout life. From conception to death, there are physical, psychological, social transformations and modifications, being vulnerable to restrictions. Interventions seek to reduce the effects of these restrictions, as children and adolescents are influenced by impoverished motor experiences in the family and school environment. The aim of this study was to evaluate the effects of an intervention program on 8-10-year-old schoolchildren in the public school system of Matinhos/PR, Brazil. Ninety-one 8-10-year-old schoolchildren from the 3rd, 4th and 5th grades were evaluated by the Motor Development Scale (MDS). Fifty-four of them presented risk of delay. Of these, 27 who performed weekly physical education classes were randomized into Control Group (CG), and 27 (Experimental Group - EG) to a psychomotor intervention program twice a week for four weeks. After interventions, EG and CG were reassessed. In the analysis of the General Motor Quotient (GMQ), it was verified that in all grades, EG presented a significant increase compared to the moment of evaluation, which was not observed among children in the CG. There was a significant increase in the averages in the reevaluation of CG and GE, however, EG presented significant differences in the Fine Motor and Balance dimensions. Intervention improved GMQ, Fine Motor and Balance compared to traditional Physical Education class.


Resumo O ser humano não tem um desenvolvimento estático ao longo da vida. Desde a concepção à morte, são conhecidas transformações e modificações físicas, psicológicas e sociais, estando vulneráveis a restrições. As intervenções buscam reduzir efeitos destas restrições, pois crianças e adolescentes sofrem influência de vivências motoras empobrecidas no meio familiar e ambiente escolar. Objetivou-se avaliar efeitos de um programa de intervenção em escolares de oito a dez anos da rede pública de ensino do município de Matinhos/PR, Brasil. Foram avaliados 91 escolares, de oito a dez anos, do 3º, 4º e 5º ano, foram avaliadas pela Escala de Desenvolvimento Motor (EDM). Destas, 54 apresentaram risco de atraso no desenvolvimento. Das 54 crianças, 27 que realizaram semanalmente aulas de Educação Física curriculares foram randomizadas no Grupo Controle (GC), e 27 (Grupo Experimental – GE) foram submetidas a uma intervenção psicomotora, duas vezes na semana, durante quatro semanas. Após as intervenções, o GE e GC foram reavaliadas. Na análise do Quociente Motor Geral (QMG), verificou-se que em todos os anos, o GE apresentou aumento significativo comparado ao momento de avaliação, fato nãoobservado entre crianças do GC. Houve elevação significativa das médias na reavaliação no GC e no GE, contudo, o GE apresentou diferenças significativas em relação ao GC, nas dimensões Motricidade Fina e Equilíbrio. A intervenção melhorou o QMG, a Motricidade fina e Equilíbrio em comparação com a aula de Educação Física tradicional.


Assuntos
Humanos , Masculino , Feminino , Criança , Exercício , Destreza Motora
20.
Acta Cir Bras ; 32(1): 1-13, 2017 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-28225912

RESUMO

Purpose: : To evaluate the effects of duodenal-jejunal bypass (DJB) on the diaphragm muscle of obese rats fed on a western diet (WD) . Methods: : Eighteen male Wistar rats were fed a standard rodent chow diet (CTL group) or WD ad libitum. After 10 weeks, WD rats were submitted to sham (WD SHAM) or duodenal-jejunal bypass (WD DJB). The structure, ultrastructure, collagen content and the morphometry of the neuromuscular junctions (NMJs) were analyzed two months after surgery. Results: : WD SHAM rats displayed an increase in body weight, the Lee index and retroperitoneal and peri-epididymal fat pads compared to the CTL group. DJB did not alter these parameters. The muscle fiber structure and NMJs were similar in the WD SHAM and CTL groups. However, the WD SHAM group showed alterations in the fiber ultrastructure, such as loosely arranged myofibrils and Z line disorganization. In addition, WD SHAM animals presented a considerable amount of lipid droplets and a reduction in the percentage of collagen compared to the CTL group. DJB did not affect the structure or ultrastructure of the muscle fibers or the NMJs in the diaphragm of the WD DJB animals. Conclusion: : Duodenal-jejunal bypass did not improve the alterations observed in the diaphragm of western diet obese-rats.


Assuntos
Diafragma/ultraestrutura , Dieta Ocidental , Duodeno/cirurgia , Jejuno/cirurgia , Junção Neuromuscular/ultraestrutura , Obesidade/cirurgia , Anastomose Cirúrgica , Animais , Masculino , Fibras Musculares Esqueléticas/ultraestrutura , Obesidade/metabolismo , Distribuição Aleatória , Ratos , Ratos Wistar
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