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2.
Ann Nutr Metab ; : 1-8, 2020 Mar 17.
Artigo em Inglês | MEDLINE | ID: mdl-32182619

RESUMO

INTRODUCTION: The role of tea consumption on rheumatoid arthritis (RA) has been studied in recent years, but no clear conclusion has been drawn as a result of small sample size of the studies or the fact that only in vitro studies have been performed. OBJECTIVES: The aim of this study was to explore the possible association of tea consumption with RA through a large-scale, real-world study. METHODS: A total of 733 RA patients were investigated from June to December, 2016. The disease activity of RA was assessed according to disease activity score 28-erythrocyte sedimentation rate. The amount and types of tea consumption were recorded by on-site self-administered questionnaires. Logistic regression models were applied to analyze the correlation between tea consumption and disease activity, adjusting for demographics, clinical and laboratory factors. RESULTS: There was an inverse association between tea consumption and disease activity in RA patients (OR 0.66, 95% CI 0.46-0.94). Compared with non-tea drinkers, a higher-intake of tea (>750 mL/day) was associated with lower disease activity of RA (OR 0.39, 95% CI 0.19-0.79), but not low-intake (≤750 mL/day; OR 0.83, 95% CI 0.42-1.63). A significant dose-response association was found between the amount of tea consumption and disease activity (p for trend <0.01). Further hierarchical regression analysis showed that such inverse associations were mainly present in female patients (p = 0.004), non-smokers (p = 0.01) or elders (≥60 years; p = 0.01). CONCLUSION: Tea consumption is associated with decreased disease activity of RA, suggesting the potential beneficial effect of tea in the disease.

3.
BMC Genomics ; 21(1): 144, 2020 Feb 10.
Artigo em Inglês | MEDLINE | ID: mdl-32041548

RESUMO

BACKGROUND: The brown planthopper (BPH, Nilaparvata lugens Stål) is a kind of phloem-feeding pest that adversely affects rice yield. Recently, the BPH-resistance gene, BPH6, was cloned and applied in rice breeding to effectively control BPH. However, the molecular mechanisms underlying BPH6 are poorly understood. RESULTS: Here, an integrated miRNA and mRNA expression profiling analysis was performed on BPH6-transgenic (BPH6G) and Nipponbare (wild type, WT) plants after BPH infestation, and a total of 217 differentially expressed miRNAs (DEMs) and 7874 differentially expressed mRNAs (DEGs) were identified. 29 miRNAs, including members of miR160, miR166 and miR169 family were opposite expressed during early or late feeding stages between the two varieties, whilst 9 miRNAs were specifically expressed in BPH6G plants, suggesting involvement of these miRNAs in BPH6-mediated resistance to BPH. In the transcriptome analysis, 949 DEGs were opposite expressed during early or late feeding stages of the two genotypes, which were enriched in metabolic processes, cellular development, cell wall organization, cellular component movement and hormone transport, and certain primary and secondary metabolite synthesis. 24 genes were further selected as candidates for BPH resistance. Integrated analysis of the DEMs and DEGs showed that 34 miRNAs corresponding to 42 target genes were candidate miRNA-mRNA pairs for BPH resistance, 18 pairs were verified by qRT-PCR, and two pairs were confirmed by in vivo analysis. CONCLUSIONS: For the first time, we reported integrated small RNA and transcriptome sequencing to illustrate resistance mechanisms against BPH in rice. Our results provide a valuable resource to ascertain changes in BPH-induced miRNA and mRNA expression profiles and enable to comprehend plant-insect interactions and find a way for efficient insect control.

4.
Nat Cell Biol ; 22(2): 246-256, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-32015438

RESUMO

The Hippo and mammalian target of rapamycin complex 1 (mTORC1) pathways are the two predominant growth-control pathways that dictate proper organ development. We therefore explored potential crosstalk between these two functionally relevant pathways to coordinate their growth-control functions. We found that the LATS1 and LATS2 kinases, the core components of the Hippo pathway, phosphorylate S606 of Raptor, an essential component of mTORC1, to attenuate mTORC1 activation by impairing the interaction of Raptor with Rheb. The phosphomimetic Raptor-S606D knock-in mutant led to a reduction in cell size and proliferation. Compared with Raptor+/+ mice, RaptorD/D knock-in mice exhibited smaller livers and hearts, and a significant inhibition of elevation in mTORC1 signalling induced by Nf2 or Lats1 and Lats2 loss. Thus, our study reveals a direct link between the Hippo and mTORC1 pathways to fine-tune organ growth.

5.
Artigo em Inglês | MEDLINE | ID: mdl-32037614

RESUMO

BACKGROUND: Left atrial substrate modification targeting low voltage zones (LVZ) is an ablation strategy that-in addition to pulmonary vein (PV) isolation-tries to eliminate arrhythmogenic mechanisms harbored in such tissue. Electrophysiological findings at reablation include (a) PV reconnection, (b) reconnection over previous substrate ablation, and (c) de-novo LVZ. OBJECTIVE: To study, prevalence and contribution of these arrhythmogenic electrophysiological entities in patients with atrial fibrillation (AF) recurrences. METHODS: Consecutive patients with highly symptomatic AF undergoing index and reablation were included (n = 113). In all patients' PV reconnection, reconnection over previous substrate ablation and spontaneous de-novo LVZ were quantitatively assessed and integrated into an individual reablation strategy. Follow-up was based on continuous device monitoring. RESULTS: At re-do procedure, 45 out of 113 (39.8%) patients showed PV reconnection as the only electrophysiological abnormality. Reconduction over previous lines was the only electrophysiological abnormality in 8 out of 113 (7.1%) patients. Spontaneous de-novo LVZ was the only electrophysiological abnormality in 12 out of 113 (10.6%) patients. Combined findings of PV reconnection, line reconduction, and/or spontaneous de-novo LVZ were seen in 40 out of 113 (35.4%) patients. No detectable electrophysiological abnormality was observed in 8 out of 113 (7.1%) patients. In univariate analysis, none of the tested electrophysiological characteristics independently predicted the outcome after re-do. CONCLUSIONS: In patients undergoing reablation, we could show that reconduction over previous substrate ablation as well as the development of new low voltage areas are frequent findings besides classical PV reconnection-without a clear leading cause for recurrences. These findings impact reablation strategies as well as the strategic focus during index procedures.

6.
Scand J Gastroenterol ; 55(2): 202-208, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-32008420

RESUMO

Aim: This study aims to establish and validate an effective nomogram to predict cancer-specific survival (CSS) in elderly patients with stages I-III colon cancer.Methods: The data of elderly colon cancer patients with stages I-III were enrolled from the Surveillance, Epidemiology, and End Results database (SEER) between 2010 and 2015. The eligible patients were randomly divided into a training cohort and a validation cohort (ratio 1:1). All predictors of cancer-specific survival were determined by Cox regression. The concordance index (C-index) and calibration curves were used for validation of nomograms. Decision curve analysis (DCA) was performed to evaluate the clinical net benefit of the nomogram.Results: Cox hazard analysis in the training cohort indicated that grade, tumor stage, node stage, colectomy, and CEA were independent predictors of CSS. Nomogram was constructed based on these predictors. The C-index of nomograms for CSS was 0.728 (95%CI: 0.7133-0.7427), and were superior to that of AJCC TNM Stage (C-index: 0.625, 95%CI: 0.6093-0.6406). The calibration curves showed satisfactory consistency between actual observation and nomogram-predicted CSS probabilities. The validation cohort demonstrated similar results. The DCA showed high net benefit of nomogram in a clinical context. The population was divided into three groups based on the scores of the nomogram, and the survival analysis showed that this prognostic stratification was statistically significant (p < 0.01).Conclusion: The nomograms showed significant accuracy in predicting 1-, 3-, and 5-year CSS in elderly patients with stages I-III colon cancer and may be helpful inpatient counseling clinical decision guidance.

7.
J Microbiol Methods ; 169: 105830, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31891738

RESUMO

The purpose of this study was to assemble two types of loop-mediated isothermal amplification (LAMP) kit that have the ability to visually detect Salmonella in ready-to-eat fruits and vegetables. The reaction results were obtained within 20-40 min after addition of DNA and can be discerned by the naked eye or an amplification plot. The stability of the LAMP wet kit was evident after multiple freezing and thawing cycles, and the one-step LAMP lyophilized kit was further evolved to allow ambient temperature transport for deployment in resource-limited settings. The cost-effective wet kit had the ability to detect minimum amounts of 1.8 CFU/ml Salmonella DNA without enrichment, while the sensitivity of the one-step LAMP lyophilized kit was only 9.8 × 103 CFU/ml. They both have good anti-interference, as they were both able to detect 2.1 × 102 CFU/ml Salmonella mixed with 106 CFU/ml four non-Salmonella strain mixture. Moreover, cucumber and lettuce that were contaminated with an initial inoculation of 1.7 CFU of Salmonella/10 g showed detection within a reaction time of 30 min after 10 h enrichment. The present research setup is a convenient and practical kit for Salmonella rapid detection that has good application prospects in food safety monitoring.

8.
J Am Coll Cardiol ; 75(3): 289-300, 2020 Jan 28.
Artigo em Inglês | MEDLINE | ID: mdl-31976867

RESUMO

BACKGROUND: Mechanistic studies have shown that morphine blunts the antiplatelet effects of oral adenosine diphosphate receptor blockers. However, the clinical relevance of this interaction is controversial. OBJECTIVES: This study sought to explore the association between morphine and ischemic events in 5,438 patients treated with concomitant clopidogrel presenting with non-ST-segment elevation acute coronary syndromes (NSTEACS) in the EARLY ACS (Early Glycoprotein IIb/IIIa Inhibition in Patients With Non-ST-Segment Elevation Acute Coronary Syndrome) trial. Patients not treated with clopidogrel (n = 3,462) were used as negative controls. METHODS: Endpoints were the composite of death, myocardial infarction (MI), recurrent ischemia, or thrombotic bailout at 96 h (4-way endpoint) and the composite of death or MI at 30 days. RESULTS: In patients treated with clopidogrel, morphine use was associated with higher rates of the 4-way endpoint at 96 h (adjusted odds ratio [OR]: 1.40; 95% confidence interval [CI]: 1.04 to 1.87; p = 0.026). There was a trend for higher rates of death or MI at 30 days (adjusted OR: 1.29; 95% CI: 0.98 to 1.70; p = 0.072), driven by events in the first 48 h (adjusted hazard ratio: 1.54; 95% CI: 1.07 to 2.23; p = 0.021). In patients not treated with clopidogrel, morphine was not associated with either the 4-way endpoint at 96 h (adjusted OR: 1.05; 95% CI: 0.74 to 1.49; p = 0.79; pinteraction = 0.36 ) or death or MI at 30 days (adjusted OR: 1.07; 95% CI: 0.77 to 1.48; p = 0.70; pinteraction = 0.46). CONCLUSIONS: When used concomitantly with clopidogrel pre-treatment, morphine was associated with higher rates of ischemic events in patients with NSTEACS. (EARLY ACS: Early Glycoprotein IIb/IIIa Inhibition in Patients With Non-ST-Segment Elevation Acute Coronary Syndrome; NCT00089895).

9.
Artigo em Inglês | MEDLINE | ID: mdl-31948227

RESUMO

The strong metal-support interaction (SMSI) is of significant importance to heterogeneous catalysis. The electronic modification and encapsulation of active metals by reducible supports are the intrinsic properties of the SMSI, where the latter would decrease or even cease the catalytic activity of transition metals. Here, we demonstrate for the first time that alkalies are the functional additives that can effectively manipulate the SMSI for better hydrogenation catalysis. Specifically, both thermodynamic analyses and experimental results show that the addition of alkalies to the Ru/TiO2 catalyst could form a titanate top layer that effectively hampers the migration of TiO2-x to the surface of Ru nanoparticles. In the meantime, a substantially enhanced reduction of the support is achieved, leading to an even stronger electron donation from the support to Ru. The alkali-modified Ru/TiO2 exhibits superior low-temperature catalytic activity in the hydrogenation of aromatics, which is ca. an order of magnitude higher than that of the commercial Ru/Al2O3 catalyst and is in clear contrast to that of the neat Ru/TiO2 catalyst that shows negligible activity due to the severe encapsulation of Ru by TiO2-x.

10.
Behav Brain Res ; 382: 112483, 2020 Mar 16.
Artigo em Inglês | MEDLINE | ID: mdl-31954737

RESUMO

The aim of this study is to investigate the alterations of interhemispheric functional connectivity in patients with postpartum depression (PPD) during resting state, and their potential correlations with clinical severity. Twenty- eight patients with PPD and twenty-five matched healthy postpartum (HP) women within 4 weeks after delivery were recruited and performed resting-state functional magnetic resonance imaging(fMRI) scans. Voxel-mirrored homotopic connectivity (VMHC), which is useful for exploring interhemispheric functional connectivity, and has been widely utilized to identify abnormal functional connectivity between the symmetrical brain regions in many diseases, was calculated in the present study, and intergroup VMHC differences in the voxel manner were analyzed. Correlations between VMHC values and clinical variables were also analyzed. Compared with HP, patients with PPD exhibited significantly decreased VMHC values in bilateral dorsomedial prefrontal cortex (dmPFC), dorsal anterior cingulate cortex (dACC) and orbitofrontal cortex (OFC). Furthermore, VMHC values within the dmPFC negatively correlated with the Edinburgh postpartum depression scale (EPDS) score. These findings suggested that functional coordination between several homotopic brain regions were impaired in patients with PPD. This study provided evidences of aberrant interhemispheric connectivity within brain regions involved in the maternal care network in PPD, and may contribute to the further understanding of the neural mechanism underlying PPD.

11.
Ann Rheum Dis ; 79(1): 141-149, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31537547

RESUMO

OBJECTIVES: Open-labelled clinical trials suggested that low-dose IL-2 might be effective in treatment of systemic lupus erythematosus (SLE). A double-blind and placebo-controlled trial is required to formally evaluate the safety and efficacy of low-dose IL-2 therapy. METHODS: A randomised, double-blind and placebo-controlled clinical trial was designed to treat 60 patients with active SLE. These patients received either IL-2 (n=30) or placebo (n=30) with standard treatment for 12 weeks, and were followed up for additional 12 weeks. IL-2 at a dose of 1 million IU or placebo was administered subcutaneously every other day for 2 weeks and followed by a 2-week break as one treatment cycle. The primary endpoint was the SLE Responder Index-4 (SRI-4) at week 12. The secondary endpoints were other clinical responses, safety and dynamics of immune cell subsets. RESULTS: At week 12, the SRI-4 response rates were 55.17% and 30.00% for IL-2 and placebo, respectively (p=0.052). At week 24, the SRI-4 response rate of IL-2 group was 65.52%, compared with 36.67% of the placebo group (p=0.027). The primary endpoint was not met at week 12. Low-dose IL-2 treatment resulted in 53.85% (7/13) complete remission in patients with lupus nephritis, compared with 16.67% (2/12) in the placebo group (p=0.036). No serious infection was observed in the IL-2 group, but two in placebo group. Besides expansion of regulatory T cells, low-dose IL-2 may also sustain cellular immunity with enhanced natural killer cells. CONCLUSIONS: Low-dose IL-2 might be effective and tolerated in treatment of SLE. TRIAL REGISTRATION NUMBER: ClinicalTrials.gov Registries (NCT02465580 and NCT02932137).

12.
Electrophoresis ; 41(3-4): 183-193, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31850545

RESUMO

In this paper, the development of a simple dilute-and-shoot method for quantifying urinary creatinine by CE-ESI-MS was described. The creatinine analysis time was about 7 min/sample by conventional single injection (SI) method and can be significantly reduced to less than 2 min/sample with multi-segment injection (MSI). In addition, the standard addition analysis of 5-hydroxyindole-3-acetic acid (5-HIAA) and creatinine normalization was performed within one run by the MSI technique, and the total analysis time was 14-min faster compared to the SI method for analyzing the same set of samples. The uses of isotopic and non-isotopic internal standards (ISs) were compared. Creatinine-(methyl-13 C) and 5-hydroxyindole-4,6,7-D3 -3-acetic-D2 acid (5-HIAA-D5 ) used as isotopic ISs can provide both accurate and precise results. In contrast, 1,5,5-trimethylhydantoin (1,5,5-TH) used as the non-isotopic IS for creatinine may cause a bias of over 13% in SI method and even worse when the MSI technique was used. Another compound, 2-methyl-3-indoleacetic acid (2-MIAA), was determined not suitable for MSI analysis of 5-HIAA due to endogenous interferences despite its acceptable performance in conventional methods of analysis.

13.
Am J Cardiol ; 125(4): 485-490, 2020 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-31870492

RESUMO

Following primary percutaneous coronary intervention (PPCI) for ST segment elevation myocardial infarction, microvascular perfusion is often impaired secondary to thrombotic embolization. Intracoronary (IC) fibrinolytic administration may reduce thrombotic burden and distal embolization. The ICE-T-TIMI-49 study evaluated the feasibility and safety of low-dose IC tenecteplase (TNK) during PPCI. The study randomized 40 PPCI patients to a volume matched bolus of IC TNK (4 mg) (n = 20) or IC saline placebo (n = 20) before and following PPCI. The primary end point was percent diameter stenosis of the culprit lesion following first bolus. The primary end point did not differ between IC placebo (median 100%, interquartile range [IQR] 83.0,100.0) and IC TNK (median 100% stenosis, IQR 91.0,100.0; p = 0.522). However, the proportion of patients with reduction in thrombus following first bolus tended to be greater with IC TNK (placebo: 12.5% vs IC TNK: 40.0%, p = 0.133). Following PPCI, the corrected Thrombolysis In Myocardial Infarction (TIMI) frame count (cTFC) was lower (faster) with placebo (16.0 frames [IQR 12.0,24.0] vs 24.0 frames [22.0,32.0], p = 0.045) due to a trend towards greater frequency of hyperemia (cTFC <14), a marker of distal embolization (50.0% vs 8.3%, p = 0.056). There was no difference in TIMI major bleeds and no intracranial hemorrhage. In conclusion, treatment with low-dose IC TNK appears safe and well tolerated during PPCI. Although IC TNK administration did not improve percent stenosis, a trend towards reduced thrombus burden was demonstrated with less hyperemia (a marker of distal embolization). Our findings provide support for a large randomized study.

14.
Mod Rheumatol ; : 1-11, 2020 Jan 07.
Artigo em Inglês | MEDLINE | ID: mdl-31859545

RESUMO

Background: Primary Sjögren's syndrome (SS) is a lymphoproliferative disease with a chronic autoimmune disorder characterized by mononuclear cell (MNC) infiltration of notably the lacrimal and salivary glands. As mesenchymal stem cells (MSCs) regulate series of immunological responses partially by regulating proportion of CD4+ T cells and inducing an immunosuppressive local milieu, umbilical cord MSCs (UC-MSCs) are being considered as a novel source for cell-based therapies against primary SS. This study aimed to investigate the feasibility of UC-MSCs in treatment of SS and to explore the possible mechanism(s) with the special emphasis on regulatory T cells (Tregs).Methods: Potent immunosuppressive effects of human UC-MSCs on SS were explored in vivo and in vitro. To study the effects of human UC-MSCs on the development and progression of SS, human UC-MSCs were administered before disease onset (preventive protocol) and after disease occurrence (therapeutic protocol) in non-obese diabetic (NOD) mice. In human study, the effect of human UC-MSCs on T cells from SS patients was studied.Results: In both protocols, the histopathology of submandibular and sublingual salivary glands showed decreased inflammatory infiltrates. In vitro, human UC-MSCs exhibited potent suppressive effects on responses of MNCs in NOD mice and T cells in SS patients. Such inhibitory effects were coupled with decreased production of proinflammtory cytokines interferon-γ, interleukin (IL)-6, tumor necrosis factor-α and increased production of IL-10 (n = 10, p < .01). The frequency of CD4+Foxp3+T cells in the spleen of NOD recipients was elevated (n = 6, p < .05).Conclusion: Human UC-MSCs are capable of inducing CD4+Foxp3+ T cells in both NOD mice and human in vitro. Human UC-MSCs effectively interfere with the autoimmune attack in the course of SS by inducing an in vivo state of T cell unresponsiveness and the upregulation of Tregs.

15.
J Am Coll Cardiol ; 74(24): 3013-3022, 2019 Dec 17.
Artigo em Inglês | MEDLINE | ID: mdl-31865968

RESUMO

BACKGROUND: It remains disputed whether women are at excess risk of adverse outcomes versus men after non-ST-segment elevation acute coronary syndromes (NSTEACS) or whether differences are explained by discordant risk factors. OBJECTIVES: A sex-specific analysis of cardiovascular outcomes after NSTEACS across trials conducted by the Thrombolysis In Myocardial Infarction (TIMI) Study Group was performed to determine the impact of sex on cardiovascular outcomes in this dataset. METHODS: Ten TIMI trials were identified that enrolled >2,500 patients with NSTEACS within 30 days of hospitalization. Cox proportional hazards models were used to examine the association of sex with major adverse cardiovascular events (MACE) (cardiovascular death, myocardial infarction, or stroke) after adjusting for relevant risk factors in individual trials; point estimates were then combined by using random effects models. Individual components of the composite outcome and all-cause mortality were also analyzed. RESULTS: Among 68,730 patients with NSTEACS, 19,827 (29%) were women. Women were older and more frequently had hypertension, diabetes, prior heart failure, and renal impairment than men. Before considering relevant confounders, women were at similar risk of MACE compared with men (hazard ratio [HR]: 1.04; 95% confidence interval [CI]: 0.99 to 1.09; p = 0.16) but at higher risk of all-cause death (HR: 1.12; 95% CI: 1.01 to 1.24; p = 0.03). After adjustment for baseline differences, risks of MACE (HR: 0.93; 95% CI: 0.88 to 0.98; p < 0.01) and all-cause death (HR: 0.84; 95% CI: 0.78 to 0.90; p < 0.0001) were lower among women compared with men. CONCLUSIONS: After accounting for cardiovascular risk factors, women enrolled in clinical trials were at lower risk of MACE than men after NSTEACS. Women, however, remain undertreated with many evidence-based therapies.

16.
Environ Sci Technol ; 53(22): 13265-13274, 2019 Nov 19.
Artigo em Inglês | MEDLINE | ID: mdl-31607119

RESUMO

Particulate matter with aerodynamic diameters ≤1 µm (PM1) has a greater impact on the human health but has been less studied due to fewer ground observations. This study attempts to improve the retrieval accuracy and spatial resolution of satellite-based PM1 estimates using the new ground-based monitoring network in China. Therefore, a space-time extremely randomized trees (STET) model is first developed to estimate PM1 concentrations at a 1 km spatial resolution from 2014 to 2018 across mainland China. The STET model can derive daily PM1 concentrations with an average across-validation coefficient of determination of 0.77, a low root-mean-square error of 14.6 µg/m3, and a mean absolute error of 8.9 µg/m3. PM1 concentrations are generally low in most areas of China, except for the North China Plain and Sichuan Basin where intense human activities and poor natural conditions are prevalent, especially in winter. Moreover, PM1 pollution has greatly decreased over the past 5 years, benefiting from emission control in China. The STET model, incorporating the spatiotemporal information, shows superior performance in PM1 estimates relative to previous studies. This high-resolution and high-quality PM1 data set in China (i.e., ChinaHighPM1) can be greatly useful for air pollution studies in medium- or small-scale areas.


Assuntos
Poluentes Atmosféricos , Poluição do Ar , China , Monitoramento Ambiental , Humanos , Material Particulado
17.
Front Genet ; 10: 869, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31620171

RESUMO

Introduction: Leukocyte immunoglobulin-like receptor A3 (LILRA3) belongs to the LILR family with unique feature of a 6.7-kb deletion variation among individuals. Frequencies of the 6.7-kb deletion vary widely across populations, but so far it has not been carefully investigated among Han Chinese subpopulations. Furthermore, we previously identified the non-deleted (functional) LILRA3 as a novel genetic risk for multiple autoimmune diseases. The current study aimed to investigate (i) whether frequencies of the LILRA3 6.7-kb deletion differ within Han Chinese subpopulations and (ii) whether the functional LILRA3 is a novel genetic risk for ankylosing spondylitis (AS). Methods: The LILRA3 6.7-kb deletion was genotyped in two independent cohorts, including 1,567 subjects from Shenzhen Hospital and 2,507 subjects from People's Hospital of Peking University. Frequencies of the 6.7-kb deletion were first investigated in combined healthy cohort according to the Chinese administrative district divisions. Association analyses were performed on whole dataset and subsets according to the geographic regions. Impact of the functional LILRA3 on AS disease activity was evaluated. Results: Frequencies of LILRA3 6.7-kb deletion were highly differentiated within Han Chinese subpopulations, being gradually decreased from Northeast (80.6%) to South (47.4%). Functional LILRA3 seemed to be a strong genetic risk in susceptibility to AS under almost all the alternative genetic models, if the study subjects were not geographically stratified. However, stratification analysis revealed that the functional LILRA3 was consistently associated with AS susceptibility mainly in Northern Han subgroup under the alternative genetic models, but not in Central and Southern Hans. Functional LILRA3 conferred an increased disease activity in AS patients (P < 0.0001 both for CRP and ESR, and P = 0.003 for BASDAI). Conclusions: The present study is the first to report that the frequencies of LILRA3 6.7-kb deletion vary among Chinese Hans across geographic regions. The functional LILRA3 is associated with AS susceptibility mainly in Northern Han, but not in Central and Southern Han subgroups. Our finding provides new evidence that LILRA3 is a common genetic risk for multiple autoimmune diseases and highlights the genetic differentiation among different ethnicities, even within the subpopulations of an ethnic group.

18.
ACS Appl Mater Interfaces ; 11(41): 38016-38022, 2019 Oct 16.
Artigo em Inglês | MEDLINE | ID: mdl-31550126

RESUMO

Controllable well-defined metal-organic frameworks (MOFs) spherical structures are expected to be potential good platforms for the heterogeneous catalysis, guest storage, and drug delivery. However, the synthesis faces a challenge. In this paper, a series of well-defined MOFs spherical structures including core-shell, yolk-shell, and hollow spheres were successfully constructed with colloidal carbon as template. Meanwhile, the shapes of MOFs unit (bricklike or octahedral) and sizes of the formed internal space can be controlled simultaneously by rationally changing the modulator and removing template in a good manner. The as-prepared structures could not only keep intact crystal textures but also be used as advanced nanoreactors for enhancing raw materials conversion in the heterogeneous reaction of synthesizing benzoin ethyl ether. Particularly, by our internal-space-controllable nanoreactors, for the first time, the quantifiable relation between nanoreactors' internal space sizes and raw material conversion was revealed.

19.
J Phys Chem C Nanomater Interfaces ; 123(35): 21487-21496, 2019 Sep 05.
Artigo em Inglês | MEDLINE | ID: mdl-31523341

RESUMO

The development of efficient catalysts for hydrogen generation via ammonia decomposition is crucial for the use of ammonia as an energy carrier. Here, we report the effect of pore confinement of NaNH2 and KNH2 on ammonia decomposition catalysis. For the first time, Ni- or Ru-doped NaNH2 and KNH2 were confined in carbon nanopores using a combination method of solution impregnation and melt infiltration. Structure characterization indicates the nanoscale intimacy between transition metals and alkali metal amides inside the pores of the carbon support. As a result, 8 wt % Ni-doped NaNH2 and KNH2 nanocomposites give NH3 conversions of 79 and 60%, respectively at 425 °C, close to the performance of a 5 wt % Ru/C reference catalyst. 0.8 wt % Ru-doped nanocomposites exhibit even better catalytic performance, with about 95% NH3 conversion at a moderate temperature of 375 °C. The hydrogen production rates of these Ni- and Ru-doped nanocomposites in a pure NH3 flow are about 3-4 times higher than for the recently reported novel catalysts such as Ni-Li2NH and Ru-Li2NH/MgO. Interestingly, the apparent activation energies of the Ru- or Ni-based catalysts decrease 20-30 kJ mol-1 by co-confinement with alkali metal amides. The strategy of nanoconfinement of alkali metal amides in porous hosts may open a new avenue for effectively generating H2 from NH3 at low temperatures.

20.
Nanomaterials (Basel) ; 9(8)2019 Aug 01.
Artigo em Inglês | MEDLINE | ID: mdl-31374845

RESUMO

Vanadium dioxide (VO2) is a temperature phase change material that has metallic properties at high temperatures and insulation properties at room temperature. In this article, a novel device has been designed based on the dielectric metasurface consisting of VO2 and graphene array, which can achieve multiple functions by adjusting temperature and voltage. When the temperature is high (340 K), the device is in the absorption state and its absorptivity can be dynamically controlled by changing the temperature. On the other hand, the device is in the polarization state under room temperature, and the polarization of electromagnetic waves can be dynamically controlled by adjusting the voltage of graphene. This device can achieve a broadband absorber (the maximum absorptance reaches 99.415% at wavelengths ranging from 44 THz to 52 THz) and high polarization conversion efficiency (>99.89%) in the mid-infrared range, which has great advantages over other single-function devices. Our results demonstrate that this multifunctional device may have widespread applications in emitters, sensors, spatial light modulators, IR camouflages, and can be used in thermophotovoltaics and wireless communication.

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