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1.
Analyst ; 146(19): 5800-5821, 2021 Sep 27.
Artigo em Inglês | MEDLINE | ID: mdl-34570846

RESUMO

Rapid diagnosis plays a vital role in daily life and is effective in reducing treatment costs and increasing curability, especially in remote areas with limited availability of resources. Among the various common methods of rapid diagnosis, centrifugal microfluidics has many unique advantages, such as less sample consumption, more precise valve control for sequential loading of samples, and accurately separated module design in a microfluidic network to minimize cross-contamination. Therefore, in recent years, centrifugal microfluidics has been extensively researched, and it has been found to play important roles in biology, chemistry, and medicine. Here, we review the latest developments in centrifugal microfluidic platforms in immunoassays, biochemical analyses, and molecular diagnosis, in recent years. In immunoassays, we focus on the application of enzyme-linked immunosorbent assay (ELISA); in biochemical analysis, we introduce the application of plasma and blood cell separation; and in molecular diagnosis, we highlight the application of nucleic acid amplification tests. Additionally, we discuss the characteristics of the methods under each platform as well as the enhancement of the corresponding performance parameters, such as the limit of detection, separation efficiency, etc. Finally, we discuss the limitations associated with the existing applications and potential breakthroughs that can be achieved in this field in the future.


Assuntos
Técnicas Analíticas Microfluídicas , Microfluídica , Ensaio de Imunoadsorção Enzimática , Imunoensaio , Técnicas de Amplificação de Ácido Nucleico
2.
J Mater Chem B ; 9(40): 8378-8388, 2021 Oct 20.
Artigo em Inglês | MEDLINE | ID: mdl-34505606

RESUMO

Rapid technology development and economic growth have brought attention to public health issues, such as food safety and environmental pollution, which creates an ever-increasing demand for fast and portable sensing technologies. Portable surface-enhanced Raman spectroscopy (SERS) capable of various analyte detection with low concentration in a convenient manner shows advantages in sensing technology including enhanced diagnostic precision, improved diagnostic efficiency, reduced diagnostic cost, and alleviation of patient pain, which emerges as a promising candidate for point-of-care testing (POCT). SERS detection technology based on different nanostructures made of noble metal-based nanomaterials can increase the sensitivity of Raman scattering by 6-8 orders of magnitude, making Raman based trace detection possible, and greatly promote the application scenarios of portable Raman spectrometers. In this perspective, we provide an overview of fundamental knowledge about the SERS mechanism including chemical and electromagnetic field enhancement mechanisms, the design and fabrication of SERS substrates based on materials, progress of using SERS for POCT in biochemical sensing and its clinical applications. Furthermore, we present the prospective of developing new nanomaterials with different functionalities for advanced SERS substrates, as well as the future advancement of biomedical sensing and clinical potential of SERS technology.

3.
Worldviews Evid Based Nurs ; 18(4): 243-250, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-34288388

RESUMO

BACKGROUND: Evidence-based practice (EBP) is a problem-solving approach to clinical decision making that leads to a higher quality and safety of health care. Three valid and reliable scales that measure EBP attributes, including the EBP Beliefs Scale, the EBP Implementation Scale, and the Organizational Culture and Readiness Scale for System-Wide Integration of EBP, are widely used but require approximately 5 min each to complete. Shorter valid and reliable versions of these scales could offer the benefit of less time for completion, thereby decreasing participant burden. AIM: The aim of this study was to determine the psychometric properties of the three shortened EBP scales, adapted from the longer versions. METHODS: This study used a descriptive survey design with 498 nurses who completed the three original EBP scales along with a shortened version of each scale. Exploratory factor analysis was conducted with principal components extracted to examine the factor structure of each EBP measure for the three shortened EBP scales. Item intercorrelations and the Kaiser-Meyer-Olkin Measure of Sampling Adequacy (KMO) were used to confirm the validity of using factor analysis. Reliability of each scale using Cronbach's α was examined. Convergent validity of the three shortened EBP scales was assessed by correlating each shortened scale with its longer scale. RESULTS: Factor analysis supported the construct validity of each of the three shortened scales, as all item intercorrelations were greater than 0.40, and KMO values were 0.62 to 0.74. The shortened scales Cronbach alphas were 0.81 for the EBP Beliefs Scale, 0.89 for the EBP Implementation Scale, and 0.87 for the EBP Culture and Readiness Scale. The three shortened EBP scales had acceptable convergent validity (r = 0.42-.072) for the correlations between the shortened and longer scales. LINKING EVIDENCE TO ACTION: The three shortened EBP scales, which are valid and reliable, can be used as an alternative to the longer three scales to decrease participant burden when conducting program evaluations, research, or organizational assessments.


Assuntos
Atitude do Pessoal de Saúde , Enfermagem Baseada em Evidências/normas , Recursos Humanos de Enfermagem no Hospital/psicologia , Cultura Organizacional , Psicometria/normas , Inquéritos e Questionários/normas , Adulto , Estudos Transversais , Análise Fatorial , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Ohio , Reprodutibilidade dos Testes
4.
Clin J Oncol Nurs ; 25(3): 282-289, 2021 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-34019024

RESUMO

BACKGROUND: Evidence-based practice (EBP) is a clinical decision-making approach that improves quality and outcomes in health care but is not yet standard in clinical settings. OBJECTIVES: The purpose of this study was to determine EBP beliefs, knowledge, implementation strategy self-efficacy, and competencies among a national sample of oncology nurses. METHODS: Oncology nurses completed an online survey of EBP attributes and open-ended questions. Analyses were conducted on data collected from 893 participants from a range of healthcare organizations across a diverse geographic sample of the United States. FINDINGS: Respondents rated themselves competent to question clinical practice to improve quality care. Oncology nurses reported competency to question clinical practice but deficits in EBP knowledge and skills.

5.
Biosens Bioelectron ; 186: 113279, 2021 Apr 24.
Artigo em Inglês | MEDLINE | ID: mdl-33979718

RESUMO

The lateral flow assay (LFA) is a widely used paper-based on-site biosensor that can detect target analytes and obtain test results in several minutes. Generally, antibodies are utilized as the biorecognition molecules in the LFA. However, antibodies selected using an in vivo process not only may risk killing the animal hosts and causing errors between different batches but also their range is restricted by the refrigerated conditions used to store them. To avoid these limitations, aptamers screened by an in vitro process have been studied as biorecognition molecules in LFAs. Based on the sandwich or competitive format, the aptamer-based LFA can accomplish on-site detection of target analytes. Since aptamers have a distinctive ability to undergo conformational changes, the adsorption-desorption format has also been exploited to detect target analytes in aptamer-based LFAs. This paper reviews developments in aptamer-based LFAs in the last three years for the detection of target analytes. Three formats of aptamer-based LFAs, i.e., sandwich, competitive, and adsorption-desorption, are described in detail. Based on these formats, signal amplification strategies and multiplexed detection are discussed in order to provide an overview of aptamer-based LFAs for on-site detection of target analytes. In addition, the potential commercialization and future perspectives of aptamer-based LFAs for rapid detection of SARS-CoV-2 are given to support the COVID-19 pandemic.

6.
Talanta ; 230: 122335, 2021 Aug 01.
Artigo em Inglês | MEDLINE | ID: mdl-33934788

RESUMO

C- reactive protein (CRP) is a sensitive indicator for infectious or inflammatory diseases in human which can reflect the body's inflammation latency and early pathophysiological changes. The most common detection method of serum CRP is ELISA that has been proved to be expensive and time-consuming, restricting its use in point-of-care application. In this paper, we demonstrated a lateral flow system for CRP quantification by using mesoporous silica (mSiO2) coated up-converting nanoparticles (UCNPs) (denoted as UCNPs@mSiO2) as fluorescent labels. The up-converting core can emit strong green fluorescence signals under NIR excitation light (980 nm) with excellent photostability, high signal-to-noise ratio and low background fluorescence. By wrapping ultrathin mSiO2 outside, the core-shell structured UCNPs@mSiO2 exhibits good dispersity and stability meanwhile maintains strong fluorescence emission. Besides, the mSiO2 shell provides further functionalities for antibody linkage. By using a portable fluorescence sensor, we reached a CRP detection limit of 0.05 ng/mL and a linear range from 0.1 ng/mL-50 ng/mL, and the detection time was no more than 8 min. The lateral flow test strips exhibit great stability in CRP quantification (CV%<5) and have a life time of more than 1 week at ambient temperature. Furthermore, the proposed system can work with a cloud-enabled smartphone through Bluetooth for Internet of Medical Things application. This CRP detection method proves to be rapid and easy-operated, which has great potential in early inflammatory disease perception in the point-of-care tests and future's 5G-enabled remote healthcare management.


Assuntos
Nanopartículas , Dióxido de Silício , Bioensaio , Proteína C-Reativa , Humanos , Prognóstico
7.
Talanta ; 227: 122207, 2021 May 15.
Artigo em Inglês | MEDLINE | ID: mdl-33714475

RESUMO

Since December 2019, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has caused millions of deaths and seriously threatened the safety of human life; indeed, this situation is worsening and many people are infected with the new coronavirus every day. Therefore, it is very important to understand patients' degree of infection and infection history through antibody testing. Such information is useful also for the government and hospitals to formulate reasonable prevention policies and treatment plans. In this paper, we develop a lateral flow immunoassay (LFIA) method based on superparamagnetic nanoparticles (SMNPs) and a giant magnetoresistance (GMR) sensing system for the simultaneously quantitative detection of anti-SARS-CoV-2 immunoglobulin M (IgM) and G (IgG). A simple and time-effective co-precipitation method was utilized to prepare the SMNPs, which have good dispersibility and magnetic property, with an average diameter of 68 nm. The Internet of Medical Things-supported GMR could transmit medical data to a smartphone through the Bluetooth protocol, making patient information available for medical staff. The proposed GMR system, based on SMNP-supported LFIA, has an outstanding advantage in cost-effectiveness and time-efficiency, and is easy to operate. We believe that the suggested GMR based LFIA system will be very useful for medical staff to analyze and to preserve as a record of infection in COVID-19 patients.


Assuntos
Anticorpos Antivirais/sangue , Imunoensaio/métodos , Imunoglobulina G/sangue , Imunoglobulina M/sangue , SARS-CoV-2/imunologia , Animais , Anticorpos Imobilizados/química , Anticorpos Imobilizados/imunologia , Anticorpos Antivirais/imunologia , Bovinos , Telefone Celular , Humanos , Imunoglobulina G/imunologia , Imunoglobulina M/imunologia , Internet das Coisas , Limite de Detecção , Nanopartículas Magnéticas de Óxido de Ferro/química , Fenômenos Magnéticos
8.
Analyst ; 146(8): 2718-2725, 2021 Apr 26.
Artigo em Inglês | MEDLINE | ID: mdl-33690736

RESUMO

Point-of-care testing (POCT) systems have been greatly developed in recent years. Among them, lateral flow immunoassay (LFIA) based on magnetic nanoparticles (MNPs) is widely used in various fields due to the advantages of small background noise and good biocompatibility. This paper designed an ultra-sensitive giant magnetic resistance (GMR) system for the quantitative detection of methamphetamine (MET). The system uses GMRs to detect the distribution of the magnetic field intensity of MNPs captured by the test (T) and control (C) lines on LFIA. A special external interference cancellation (EIC) method and a weak-signal waveform reconstruction method were used to improve the accuracy of the detection. Finally, the T/C ratio was calculated to realize the quantitative detection of MET. The result showed good linear performance with a detection limit of 0.1 ng mL-1. The system can also be used in other fields such as disease detection, food analysis, and environmental testing.


Assuntos
Imunoensaio , Metanfetamina , Nanopartículas , Limite de Detecção , Campos Magnéticos , Magnetismo , Metanfetamina/análise , Metanfetamina/toxicidade
9.
Biosens Bioelectron ; 181: 113160, 2021 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-33740542

RESUMO

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is spreading around the globe since December 2019. There is an urgent need to develop sensitive and online methods for on-site diagnosing and monitoring of suspected COVID-19 patients. With the huge development of Internet of Things (IoT), the impact of Internet of Medical Things (IoMT) provides an impressive solution to this problem. In this paper, we proposed a 5G-enabled fluorescence sensor for quantitative detection of spike protein and nucleocapsid protein of SARS-CoV-2 by using mesoporous silica encapsulated up-conversion nanoparticles (UCNPs@mSiO2) labeled lateral flow immunoassay (LFIA). The sensor can detect spike protein (SP) with a detection of limit (LOD) 1.6 ng/mL and nucleocapsid protein (NP) with an LOD of 2.2 ng/mL. The feasibility of the sensor in clinical use was further demonstrated by utilizing virus culture as real clinical samples. Moreover, the proposed fluorescence sensor is IoMT enabled, which is accessible to edge hardware devices (personal computers, 5G smartphones, IPTV, etc.) through Bluetooth. Medical data can be transmitted to the fog layer of the network and 5G cloud server with ultra-low latency and high reliably for edge computing and big data analysis. Furthermore, a COVID-19 monitoring module working with the proposed the system is developed on a smartphone application (App), which endows patients and their families to record their medical data and daily conditions remotely, releasing the burdens of going to central hospitals. We believe that the proposed system will be highly practical in the future treatment and prevention of COVID-19 and other mass infectious diseases.


Assuntos
Técnicas Biossensoriais , COVID-19/diagnóstico , Sistemas Computacionais , Imunoensaio , Fluorescência , Humanos , Prognóstico , SARS-CoV-2
10.
IEEE Trans Biomed Circuits Syst ; 15(1): 171-176, 2021 02.
Artigo em Inglês | MEDLINE | ID: mdl-33600321

RESUMO

Point-of-care testing (POCT) is characterized by fast detection, simple use, and cost efficiency. As the focus of healthcare shifts to precision medicine, population health, and chronic disease management, the potential impact of POCT has increased significantly in the past decade. Immunochromatographic test strips (ICTSs) are currently the most promising POCT diagnostic format due to the advantages of fast detection, simple operation and cost-effective. The lateral flow immune analyzer (LFIA) system that uses magnetic resistance (MR) sensors as readers and magnetic nanoparticle labeling materials has attracted wide attention due to its high sensitivity and specificity. This paper designs a quantitative lateral flow immunoassay instrument for MR sensors using InSb single crystals as magnetoresistive elements. MR sensors detect samples of ICTSs labeled with superparamagnetic nanoparticles (SMNPs). The collected weak magnetic signal is processed by the designed amplifying circuit and software algorithm. As a result, the MR system can quantitatively detect the concentration of morphine (MOP), and has good repeatability. Compared with other optical detection instruments, the system has good specificity because there is very low background noise in the detection sample. The size of the whole system is [Formula: see text], and it has the characteristics of compactness and fast detection.

11.
J Clin Nurs ; 2021 Feb 16.
Artigo em Inglês | MEDLINE | ID: mdl-33590558

RESUMO

AIMS AND OBJECTIVES: The purpose of this study was to compare the experience of a new clinical model with traditional clinical teaching and examine the effects of evidence-based practice strategies among staff and student nurses. BACKGROUND: This provides an innovative approach to nursing student clinical learning that emphasised the academic-clinical partnership with the use of a new model called the Evidence-based Clinical Academic Partnership (ECAP) model. The model incorporates three main components (a) unit transformation into an innovative hybrid version of a dedicated education unit (hDEU); (b) Evidence-in-Action (EIA) rounding; and (c) the cognitive apprenticeship theoretical framework. DESIGN: This pilot study used a mixed-method, quasi-experimental design. METHODS: The quantitative portion included a pre-test, post-test non-randomised quasi-experimental design using self-reported survey data. The qualitative methodology used was a hermeneutic phenomenological approach to data interpretation of three focus groups with staff nurses and unit leaders. SQUIRE 2.0 guidelines were followed (Ogrinc et al., 2016). CONCLUSIONS: The themes that emerged emphasised relationships and the partnership with this innovative approach to clinical teaching. The staff nurses emphasised the need for a collaborative approach and having the presence of the academic faculty member as a way to support the teaching and learning aspects with students. RELEVANCE TO CLINICAL PRACTICE: This study did provide significant contributions to the development of an innovative clinical model and highlighted the importance of the academic-clinical partnership with the education of undergraduate nursing students. The study results provided insight to the ways the hDEU framework may be strengthened, such as increased communication and partnership in the implementation of the ECAP model. Implementing curricular change to include innovative clinical models within a nursing programme is vital in this time of healthcare transformation.

12.
Lab Chip ; 21(4): 784, 2021 Feb 21.
Artigo em Inglês | MEDLINE | ID: mdl-33527963

RESUMO

Correction for 'Modular off-chip emulsion generator enabled by a revolving needle' by Yuxin Zhang et al., Lab Chip, 2020, 20, 4592-4599, DOI: .

13.
IEEE Trans Nanobioscience ; 20(1): 2-8, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-33079655

RESUMO

Recently, drug abuse has become a worldwide concern. Among varieties of drugs, KET is found to be favorite in drug addicts, especially teenagers, for recreational purposes. KET is a kind of analgesic and anesthetic drug which can induce hallucinogenic and dissociative effects after high-dose abuse. Hence, it is critical to develop a rapid and sensitive detection method for strict drug control. In this study, we proposed a cloud-enabled smartphone based fluorescence sensor for quantitative detection of KET from human hair sample. The lateral flow immunoassay (LFIA) was used as the detecting strategy where UCNPs were introduced as fluorescent labels. The sensor was capable of identifying the up-converted fluorescence and calculating the signal intensities on TL and CL to obtain a T/C value, which was corresponding to the KET concentration. The sensor transmitted the test data to the cloud-enabled smartphone through Type-C interface, and the data were further uploaded to the edge of the network for cloud-edge computing and storage. The entire detection took only 5 minutes with high stability and reliability. The detection limit of KET was 1 ng/mL and a quantitative detection range from 1 to 150 ng/mL. Furthermore, based on the huge development of Internet of Things (IoT), an App was developed on the smartphone for anti-drug situational awareness. Based on this system, it was convenient for Police Department to perform on-site KET detection. Moreover, it was critical for prediction of the development trend of future events, benefiting much to constructing a harmonious society.

14.
Analyst ; 146(3): 989-996, 2021 Feb 08.
Artigo em Inglês | MEDLINE | ID: mdl-33295357

RESUMO

An up-conversion luminescent material converts low-frequency excitation light into high-frequency emission light through photons and has the advantages of long fluorescence lifetime, narrow emission peak and low toxicity; thus, this material has many unique applications in the detection and identification of biomolecules. In this study, an ultrasensitive up-conversion luminescent system for the quantitative detection of morphine was developed. The principle of this system is based on infrared light as an excitation light source to convert light with lower energy into excitation light with higher energy. The up-conversion luminescent material is used as a label and through the processing and analysis of the excitation light intensity, the quantitative detection of morphine concentration is achieved. At the same time, the excitation light can avoid the interference and scattering phenomenon of the autofluorescence of the biological sample, which improves the system's detection sensitivity. An algorithm for light intensity processing is added to process image data, reduce the interference caused by noise during image acquisition and improve the accuracy of morphine detection. The T/C value is calculated to achieve the quantitative detection of morphine with a detection limit of 0.1 ng mg-1 and detection time within 0.5 min. The up-conversion luminescent system has the advantages of quantitative detection, convenience, portability, short detection time and low price. Thus, the system can be used for the detection of other biomolecules or for other applications such as food analysis, environmental detection, national security, etc.


Assuntos
Luminescência , Morfina , Fluorescência , Raios Infravermelhos , Medições Luminescentes , Fótons
15.
ACS Appl Mater Interfaces ; 13(1): 186-195, 2021 Jan 13.
Artigo em Inglês | MEDLINE | ID: mdl-33351580

RESUMO

In virtue of uniform mesopores and core-shell nanoarchitectures, metallic nanodot-encapsulated hollow mesoporous nanostructures have shown promising potential in various applications. However, their fabrication with versatile tunability of the encapsulated metallic content has been a challenge. Herein, we have prepared metallic nanodot-encapsulated hollow mesoporous silica nanoparticles (M-HMSNPs) with adjustable inner metallic components. The sacrificial template of polystyrene (PS) nanoparticles precoated with metals (Au/Ag/Pt) is fully wrapped with mesoporous silica (mSiO2). The metallic nanodots are formed during the template removal process by calcination. The type and content of the encapsulated nanodots can be readily and precisely controlled by the initially deposited metallic layers. We demonstrate the application of the gold (Au) nanodot-loaded HMSNPs (denoted Au-HMSNPs) as smart surface-enhanced Raman spectroscopy (SERS) probes, which can screen between big molecules and small analytes. With the aid of a Raman reporter, the SERS probe can successfully quantify H2O2, which is used to distinguish cancer cells in vitro. Further integrated with enzymes, the SERS chips of specificity are prepared and used to detect corresponding substrates of glucose and uric acid, responsively. Besides SERS sensing, the current strategy can inspire future development of many other M-HMSNPs for various applications such as catalysis, energy storage, theranostics, etc.

16.
Talanta ; 222: 121645, 2021 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-33167274

RESUMO

This paper reviews the recent development of electrochemical sensors for the detection of vitamins over the past three years. Vitamins present in natural foodstuffs are a group of organic compounds that are indispensable to maintain human health. While they are only present in minute amounts, they still play a significant role in healthy metabolism. The deficiency of vitamins in the human body often leads to numerous diseases. Because the human body cannot synthesize most vitamins, it is necessary to obtain them from dietary sources. For these reasons, the detection of vitamins has gained widespread attention in recent years. As it is well known, almost all vitamins are electrochemically active. Based on the electrochemical oxidation or reduction reaction of the vitamins in an electrolyte, electrochemical sensors can obtain the concentration of the vitamins by measurement of the current at the working electrode. Electrochemical sensors for detecting water-soluble vitamins, such as vitamin B1, vitamin B2, vitamin B6, vitamin B9, vitamin B12, and vitamin C are discussed in detail. A comprehensive overview of electrochemical sensors for detecting fat-soluble vitamins, such as vitamin A, vitamin D, vitamin E, and vitamin K, is also provided. Furthermore, the strategies employed and the performance of the electrochemical sensors for detecting vitamins are described. Finally, current challenges and future prospects of electrochemical sensors for the detection of vitamins are discussed.


Assuntos
Vitamina E , Vitaminas , Ácido Ascórbico , Humanos , Vitamina D , Vitamina K , Vitaminas/análise
17.
Lab Chip ; 20(24): 4592-4599, 2020 12 15.
Artigo em Inglês | MEDLINE | ID: mdl-33150901

RESUMO

Microfluidic chips have demonstrated unparalleled abilities in droplet generation, including precise control over droplet size and monodispersity. And yet, their rather complicated microfabrication process and operation can be a barrier for inexperienced researchers, which hinders microdroplets from unleashing their potential in broader fields of research. Here, we attempt to remove this barrier by developing an integrated and modular revolving needle emulsion generator (RNEG) to achieve high-throughput production of uniformly sized droplets in an off-chip manner. The RNEG works by driving a revolving needle to pinch the dispersed phase in a minicentrifuge tube. The system is constructed using modular components without involving any microfabrication, thereby enabling user-friendly operation. The RNEG is capable of producing microdroplets of various liquids with diameters ranging from tens to hundreds of micrometres. We further examine the principle of operation using numerical simulations and establish a simple model to predict the droplet size. Moreover, by integrating curing and centrifugation processes, the RNEG can produce hydrogel microparticles and transfer them from an oil phase into a water phase. Using this ability, we demonstrate the encapsulation and culture of single yeast cells within hydrogel microparticles. We envisage that the RNEG can become a versatile and powerful tool for high-throughput production of emulsions to facilitate diverse biological and chemical research.

18.
Sensors (Basel) ; 20(19)2020 Sep 30.
Artigo em Inglês | MEDLINE | ID: mdl-33007833

RESUMO

In this work, a biological retina inspired tone mapping processor for high-speed and energy-efficient image enhancement has been proposed. To achieve high throughput and high energy efficiency, several hardware design techniques have been proposed, including data partition based parallel processing with S-shape sliding, adjacent frame feature sharing, multi-layer convolution pipelining, and convolution filter compression with zero skipping convolution. Implemented on a Xilinx's Virtex7 FPGA, the proposed design achieves a high throughput of 189 frames per second for 1024 × 768 RGB images while consuming 819 mW. Compared with several state-of-the-art tone mapping processors, the proposed design shows higher throughput and energy efficiency. It is suitable for high-speed and energy-constrained image enhancement applications.


Assuntos
Algoritmos , Aumento da Imagem/instrumentação , Retina/diagnóstico por imagem , Desenho de Equipamento , Humanos
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