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1.
Artigo em Inglês | MEDLINE | ID: mdl-34639506

RESUMO

This study aims to explore and compare the influences of two crucial information channels used by middle-aged parents-media and their adult children-on their health knowledge, emotions and preventive behaviors against COVID-19, based on media exposure and the family communication patterns (FCP) theory. Parents of college students in Guangzhou, China were invited to participate in an online survey between February 10 and 24, 2020. A total of 193 respondents, aged between 40 and 65 years, completed the study questionnaire. Media exposure was a positive predictor of negative emotions, intergenerational discussions, and preventive behaviors among Chinese middle-aged parents. Conversation orientation was a positive predictor of scientific discussions and preventive behaviors, whereas conformity orientation was a negative predictor of knowledge, but a positive predictor of intergenerational discussions and negative emotions. Intergenerational discussions mediated the relationships between media exposure and preventive behaviors, as well as between FCP and preventive behaviors. Health communication efforts require the help of adult children as intergenerational communication serves as an important amplifier in terms of influencing the health knowledge, attitudes, and behaviors of middle-aged and elderly populations.


Assuntos
COVID-19 , Comunicação em Saúde , Adulto , Idoso , Criança , China , Comunicação , Estudos Transversais , Conhecimentos, Atitudes e Prática em Saúde , Humanos , Pessoa de Meia-Idade , SARS-CoV-2 , Inquéritos e Questionários
2.
Aging Clin Exp Res ; 2021 Oct 14.
Artigo em Inglês | MEDLINE | ID: mdl-34648174

RESUMO

BACKGROUND: Although frailty as a common geriatric syndrome is associated with postoperative complications, its relationship with postoperative pulmonary complications (PPCs) following pulmonary resections in elderly patients is unclear. AIMS: To investigate the relationship between frailty and PPCs in elderly patients undergoing video-assisted thoracoscopic pulmonary resections and explore the effect of the addition of frailty assessment to PPC risk index and ASA on their predictive ability. METHODS: In a prospective cohort study, we measured frailty status using the FRAIL scale in elderly patients undergoing video-assisted thoracoscopic pulmonary resections. Multivariate analysis was used to identify the relationship between frailty and PPCs. Receiver operating characteristic curves were used to examine the predictive power of frailty and other assessment tools. RESULTS: 227 patients were analyzed in the study. The prevalence of PPCs was 24.7%. Significant differences between patients with and without PPCs were observed in the following aspects: BMI, smoking, COPD, respiratory infection within the last month, FEV1/FVC ratio, creatinine, ASA, frailty and PPC risk index (p < 0.05, respectively). After adjusting for all covariates, frailty was significantly related to PPCs in elderly patients (odds ratio: 6.33, 95% confidence interval: 2.45-16.37). Combined with frailty assessment, the area under the curve for ASA class and PPC risk index was increased to 0.759 (95% CI 0.687-0.831) and 0.821 (95% CI 0.758-0.883). CONCLUSIONS: Frailty was associated with PPCs in elderly patients undergoing video-assisted thoracoscopic pulmonary resections. Combined with the frailty assessment, the predictive power of the PPC risk index and ASA class was improved.

3.
Chemosphere ; 282: 131057, 2021 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-34470151

RESUMO

Recently, the combination of peroxymonosulfate (PMS) and hydroxylamine (HA) has been proposed as a green and efficient sulfate radical ()-based advanced oxidation process (AOP) for eliminating organic contaminants. However, we found that toxic nitrosated and nitrated aromatic compounds were generated during the treatment of phenolic compounds by PMS/HA system, indicating the involvement of reactive nitrogen species (RNS) during the interaction of PMS with HA. Specifically, considerable production of p-nitrosophenol (p-NSP) and mononitrophenol were obtained when phenol was oxidized by PMS/HA system under various conditions. At the molar ratio between HA and PMS of 1.0 and pH 5.0, sum of the yields of p-NSP and nitrophenols reached their maxima (around 50%). Moreover, production of p-NSP was inhibited while that of nitrophenols was promoted when applied NH2OH1/2H2SO4 was replaced by NH2OHHCl, which was possibly related to the formation of secondary reactive species induced by the reaction of with chloride ion. Further, formation of undesirable nitrosated and nitrated aromatic products was obtained in the treatment of other phenolic compounds including acetaminophen, bisphenol A, and bisphenol S by PMS/HA system. Considering the toxicity of nitrosated and nitrated aromatic compounds, practical application of PMS/HA system for environmental decontamination should be scrutinized.


Assuntos
Nitratos , Poluentes Químicos da Água , Hidroxilamina , Hidroxilaminas , Oxirredução , Peróxidos , Fenóis , Poluentes Químicos da Água/análise
4.
Pediatr Infect Dis J ; 2021 Sep 09.
Artigo em Inglês | MEDLINE | ID: mdl-34508026

RESUMO

BACKGROUND: China has a high burden of tuberculosis and latent tuberculosis infection (LTBI). The aim of this study was to estimate the prevalence of LTBI among healthy young children and adolescents and test a 2-step approach to explore the threshold for the diagnosis of tuberculosis infection in Chengdu, China. METHODS: Healthy preschool children and school-going children in Chengdu, Sichuan Province, were screened for LTBI using the tuberculin skin test (TST). Preschool children with TST ≥ 5 mm also underwent interferon-γ release assay (IGRA) to explore the threshold of this 2-step approach. RESULTS: In total, 5667 healthy young children and adolescents completed TST test between July 2020 and January 2021 and were included in the present analysis. The age of the participants ranged from 2.4 to 18 years (median 7.25 ± 4.514 years), of which 2093 (36.9%) were younger than 5 years. The overall prevalence of LTBI was 6.37% and 6.64% in children younger than 5 years old. Fourteen of the 341 preschool children with TST ≥5 mm were interferon-γ release assay positive, of which 4 showed a TST result of 5-10 mm, and 6 preschool children received preventive treatment for LTBI. CONCLUSIONS: Healthy young children and adolescents should also be considered as important target populations for LTBI screening. TST can be recommended for first-line screening as part of a 2-step approach for LTBI screening using a positive threshold of 5 mm.

5.
Food Chem ; 368: 130687, 2021 Jul 24.
Artigo em Inglês | MEDLINE | ID: mdl-34416486

RESUMO

The solubility and physicochemical properties of resveratrol in peanut oil were systematically studied following ultrasonic and magnetic stirring-assisted dissolution. The highest resveratrol solubility in peanut oil observed was 95.91%. The optimal dissolution process was determined to be the addition of 183.00 mg/kg resveratrol, a magnetic temperature of 40.00℃, and a magnetic duration of 3.50 h, which yielded a resveratrol content of 175.51 mg/kg oil. Under this standardized process, the oil composition remained unchanged. Resveratrol promoted the conversion of saturated triglycerides into unsaturated triglycerides, increased the linolenic acid content, and did not facilitate the formation of trans fatty acids. In addition, resveratrol preservedthe lightcolor, decreased the peroxide and acid values by 30%, prolonged the shelf life by more than 2 folds, and improved the thermal stability. In this sense, peanut oil with resveratrol can serve as anti-isomerism and antioxidant additive.

6.
Adv Sci (Weinh) ; : e2101526, 2021 Aug 26.
Artigo em Inglês | MEDLINE | ID: mdl-34436822

RESUMO

Reperfusion injury is still a major challenge that impedes neuronal survival in ischemic stroke. However, the current clinical treatments are remained on single pathological process, which are due to lack of comprehensive neuroprotective effects. Herein, a macrophage-disguised honeycomb manganese dioxide (MnO2 ) nanosphere loaded with fingolimod (FTY) is developed to salvage the ischemic penumbra. In particular, the biomimetic nanoparticles can accumulate actively in the damaged brain via macrophage-membrane protein-mediated recognition with cell adhesion molecules that are overexpressed on the damaged vascular endothelium. MnO2 nanosphere can consume excess hydrogen peroxide (H2 O2 ) and convert it into desiderated oxygen (O2 ), and can be decomposed in acidic lysosome for cargo release, so as to reduce oxidative stress and promote the transition of M1 microglia to M2 type, eventually reversing the proinflammatory microenvironment and reinforcing the survival of damaged neuron. This biomimetic nanomedicine raises new strategy for multitargeted combined treatment of ischemic stroke.

7.
Water Res ; 203: 117513, 2021 Sep 15.
Artigo em Inglês | MEDLINE | ID: mdl-34392042

RESUMO

Permanganate (Mn(VII)) has been widely studied for removal of emerging organic contaminants (EOCs) in water treatment and in situ chemical oxidation process. Studies on the reactive intermediate manganese products (e.g., Mn(III) and manganese dioxide (MnO2)) generated from Mn(VII) reduction by EOCs in recent decades shed new light on Mn(VII) oxidation process. The present work summarizes the latest research findings on Mn(VII) reactions with a wide range of EOCs (including phenols, olefins, and amines) in detailed aspects of reaction kinetics, oxidation products, and toxicity changes, along with special emphasis on the impacts of intermediate manganese products (mainly Mn(III) and MnO2) in-situ formed. Mn(VII) shows appreciable reactivities towards EOCs with apparent second-order rate constants (kapp) generally decrease in the order of olefins (kapp = 0.3 - 2.1 × 104 M-1s-1) > phenols (kapp = 0.03 - 460 M-1s-1) > amines (kapp = 3.5 × 10-3 - 305.3 M-1s-1) at neutral pH. Phenolic benzene ring (for phenols), (conjugated) double bond (for olefins), primary amine group and the N-containing heterocyclic ring (for amines) are the most reactive sites towards Mn(VII) oxidation, leading to the formation of products with different structures (e.g., hydroxylated, aldehyde, carbonyl, quinone-like, polymeric, ring-opening, nitroso/nitro and C-N cleavage products). Destruction of functional groups of EOCs (e.g., benzene ring, (conjugated) double bond, and N-containing heterocyclic) by Mn(VII) tends to decrease solution toxicity, while oxidation products with higher toxicity than parent EOCs (e.g., quinone-like products in the case of phenolic EOCs) are sometimes formed. Mn(III) stabilized by model or unknown ligands remarkably accelerates phenolic EOCs oxidation by Mn(VII) under acidic to neutral conditions, while MnO2 enhances the oxidation efficiency of phenolic and amine EOCs by Mn(VII) at acidic pH. The intermediate manganese products participate in Mn(VII) oxidation process most likely as both oxidants and catalysts with their generation/stability/reactivity affecting by the presence of NOM, ligand, cations, and anions in water matrices. This work presents the state-of-the-art findings on Mn(VII) oxidation of EOCs, especially highlights the significant roles of manganese products, which advances our understanding on Mn(VII) oxidation and its application in future water treatment processes.


Assuntos
Compostos de Manganês , Óxidos , Cinética , Manganês , Oxirredução , Estresse Oxidativo
8.
Adv Sci (Weinh) ; : e2102256, 2021 Aug 16.
Artigo em Inglês | MEDLINE | ID: mdl-34398516

RESUMO

A versatile tumor-targeting stimuli-responsive theranostic platform for peritoneal metastases of colorectal cancer is proposed in this work for tumor tracking and photothermal-enhanced chemotherapy. A quenched photosensitizer ("off" state) is developed and escorted into a tumor-targeting oxaliplatin-embedded micelle. Once reaching the tumor cell, the micelle is clasped to release free oxaliplatin, as well as the "off" photosensitizer, which is further activated ("turned-on") in the tumor reducing microenvironment to provide optical imaging and photothermal effect. The combined results from hyperthermia-enhanced chemotherapy, deep penetration, perfused O2 , and the leveraged GSH-ROS imbalance in tumor cells are achieved for improved antitumor efficacy and reduced systematic toxicity.

9.
ACS Nano ; 2021 Aug 12.
Artigo em Inglês | MEDLINE | ID: mdl-34382768

RESUMO

Metabolic interactions between different cell types in the tumor microenvironment (TME) often result in reprogramming of the metabolism to be totally different from their normal physiological processes in order to support tumor growth. Many studies have attempted to inhibit tumor growth and activate tumor immunity by regulating the metabolism of tumors and other cells in TME. However, metabolic inhibitors often suffer from the heterogeneity of tumors, since the favorable metabolic regulation of malignant cells and other cells in TME is often inconsistent with each other. Therefore, we reported the design of a pH-sensitive drug delivery system that targets different cells in TME successively. Outer membrane vesicles (OMVs) derived from Gram-negative bacteria were applied to coload paclitaxel (PTX) and regulated in development and DNA damage response 1 (Redd1)-siRNA and regulate tumor metabolism microenvironment and suppress tumor growth. Our siRNA@M-/PTX-CA-OMVs could first release PTX triggered by the tumor pH (pH 6.8). Then the rest of it would be taken in by M2 macrophages to increase their level of glycolysis. Great potential was observed in TAM repolarization, tumor suppression, tumor immune activation, and TME remolding in the triple-negative breast cancer model. The application of the OMV provided an insight for establishing a codelivery platform for chemical drugs and genetic medicines.

10.
Arch Biochem Biophys ; 710: 109000, 2021 10 15.
Artigo em Inglês | MEDLINE | ID: mdl-34343486

RESUMO

Impaired endothelium-mediated vasodilation and/or increased sensitivity to vasoconstrictors lead to vascular smooth muscle cell (VSMC) dysfunction in individuals with diabetes. Diabetic nephropathy is associated with a considerably higher risk of cardiovascular disease and death than their nondiabetic counterparts. We studied the activity of Cullin 3 RING ubiquitin ligase (CRL3) and its substrates in mice using an intraperitoneal injection of streptozotocin (STZ) and db/db mice. The levels of CRL3 adaptors, including Kelch-like 2/3 (KLHL2/3) and Rho-related BTB domain-containing protein 1, were significantly decreased in the aortic tissues and heart of the STZ group, whereas the levels of Cullin 3 (CUL3) and its neddylated derivatives were substantially increased. Decreased KLHL3 expression and significantly increased expression of NEDD8 conjugates were observed in the kidneys of db/db mice. The neddylation inhibitor MLN4924 decreased the degradation of KLHL2/KLHL3 under high-glucose conditions with/without insulin, and transfection with KLHL2 promoted the degradation of its substrates with-no-lysine (WNK) kinases. Increased abundance of WNK3, RhoA/ROCK activity and phosphodiesterase 5 enhanced the sensibility to vasoconstrictors and impaired vasodilation. Moreover, WNK3 localized in VSMCs undergoing cell division, and high-glucose medium increased WNK3 signaling in VSMCs undergoing mitosis, which might explain the increased thickness of aortic tissues in subjects with diabetes. Increases in WNK4 abundance resulted in increased sodium reabsorption in the distal renal tubules. Thus, KLHL2/RhoBTB1/KLHL3 inactivation in the aortic tissues and kidney is a result of excessive activation of neddylation in hyperglycemia and hyperinsulinemia, which affects vascular tone and sodium reabsorption.


Assuntos
Proteínas Culina/metabolismo , Diabetes Mellitus Experimental/metabolismo , Diabetes Mellitus Experimental/fisiopatologia , Sódio/metabolismo , Ubiquitina-Proteína Ligases/metabolismo , Vasoconstrição/fisiologia , Animais , Aorta/metabolismo , Aorta/patologia , Células Cultivadas , Diabetes Mellitus Experimental/patologia , Diabetes Mellitus Tipo 1/metabolismo , Diabetes Mellitus Tipo 1/patologia , Diabetes Mellitus Tipo 1/fisiopatologia , Humanos , Rim/metabolismo , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Camundongos Obesos , Proteínas dos Microfilamentos/antagonistas & inibidores , Proteínas do Tecido Nervoso/antagonistas & inibidores , Proteínas Serina-Treonina Quinases/metabolismo , Ratos , Proteínas rho de Ligação ao GTP/antagonistas & inibidores , Quinases Associadas a rho/metabolismo , Proteína rhoA de Ligação ao GTP/metabolismo
11.
Leuk Res ; 111: 106688, 2021 Aug 18.
Artigo em Inglês | MEDLINE | ID: mdl-34450501

RESUMO

BACKGROUND: Interstitial pneumonitis (IP), a fatal complication of DLBCL treatment, can bring great challenges to clinicians. We retrospectively investigated clinical characteristics and risk factors of previous IP patients, and analyzed their survival data. METHODS: 556 DLBCL patients receiving CHOP-like regimens were enrolled between 2013 and 2018 in Sichuan Cancer Hospital. FINDINGS: The IP incidences were 4.9 % (27/556), 1.1 % (2/186), 5.2 % (10/191) and 8.4 % (15/179) in CHOP, R-CHOP and R-CDOP groups respectively (P = 0.005). When IP was diagnosed, monocyte and IL-6 were significantly higher while CD4 and CD4/CD8 significantly lower compared to baseline. 81.5 % (22/27) of IP patients were pathogen-negative with good response to glucocorticoid monotherapy. Only one patient died while the others recovered from IP and subsequently underwent previous chemotherapy. 19.2 % (5/26) of IP patients experienced IP recurrence, likely due to the reason of lower initial dose or faster withdrawal speed of glucocorticoid. Multivariate analysis identified male, in addition to G-CSF, rituximab and pegylated liposomal doxorubicin as risk factors. The 3-year PFS and OS were 74.1 % and 46.9 % respectively for patients with IP. INTERPRETATION: We suggest that IL-6, monocyte and CD4 should be monitored closely, especially in R-CHOP/R-CDOP group. Sufficient initial dose and slow decrease of glucocorticoid based on radiographic remissions were critical strategies to reduce IP recurrence. We speculate that drug-induced immune imbalance could be trigger of developing IP, causing a lower intensity cytokine storm, resulting in a potential immunotherapy. This complication might bring benefit in patients' survival through a mechanism similar to PD-1.

12.
Biochem Biophys Res Commun ; 572: 98-104, 2021 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-34364296

RESUMO

BACKGROUND: Cancer-induced bone pain (CIBP) is one of the most severe types of chronic pain which the involved mechanisms are largely unknown. LncRNA has been found to play critical roles in chronic pain. However, its function in peripheral nervous system in CIBP remains unknown. Identifying the different lncRNA expression pattern is essential for understanding the genetic mechanisms underlying the pathogenesis of CIBP. METHODS: The model was induced by injection of Walker 256 cells into the rat tibia canal. Behavior tests and X-ray microtomography (MicroCT) analysis were performed to verify the model's establishment. L2-L5 DRGs were harvested at 14-day post operation and the differential lncRNA and mRNA expression patterns were investigated by microarray analyses. RT-qPCR analysis and RNA interference were performed for expression and function verifications. Bioinformatics analysis was conducted for further function study. RESULTS: CIBP rats showed hyperalgesia and the MicroCT analysis showed tibia destruction. A total of 73 lncRNAs and 187 mRNAs were dysregulated. The expressions of several lncRNAs and mRNAs were validated by RT-qPCR experiment. Biological analyses showed that the changed mRNAs were mainly related to cellular and single-organism process, cell and cell part, binding function and immune system pathway. The top 30 lncRNA-predicted mRNAs are mainly related to peroxisome, DNA-dependent DNA replication, double-stranded RNA binding, tuberculosis and purine metabolism. 56 lncRNAs (30 downregulated and 26 upregulated) and 179 DEGs (35 downregulated and 144 upregulated) have a significant correlation and constructed a co-expression network. Downregulation of lncRNA NONRATT021203.2 by siRNA intrathecal injection increased PWL and WBD in CIBP rats, alleviating cancer induced bone hyperalgesia. CONCLUSION: LncRNA played important roles in regulation of CIBP or mRNA expression in peripheral neuropathy in CIBP. These alterd mRNAs and lncRNAs might be potential therapeutic targets for the treatment of CIBP.

13.
Ying Yong Sheng Tai Xue Bao ; 32(7): 2644-2652, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-34313083

RESUMO

With rapid urbanization, the increasing building stock, building operation energy consumption and the corresponding carbon emissions have become the important factors restricting the sustainable development of cities. To reduce energy consuming, it is necessary to explore the mechanisms underlying building's operational energy consumption and carbon emission. Although previous studies have analyzed the influencing factors and driving mechanism of urban building carbon emission from different perspectives, a systematical review of the relevant studies which could provide comprehensive guidance for building energy conservation and consumption reduction is fairly scarce. Following the Social-Economic-Natural Complex Ecosystem theory, we comprehensively discussed the driving mechanisms of the building's operational energy consumption and carbon emission. We further analyzed the various single-source driving mechanisms from the perspective of socio-economic, building feature, regional climate and microclimate conditions. Finally, we tackled the weaknesses of current researches and addressed the prospect for future development. The driving mechanism summarized in this work would contribute to the development of related research and support low carbon city construction.


Assuntos
Carbono , Ecossistema , Carbono/análise , Dióxido de Carbono/análise , China , Cidades , Urbanização
14.
J Hazard Mater ; 417: 126030, 2021 09 05.
Artigo em Inglês | MEDLINE | ID: mdl-34229380

RESUMO

In this work, we found that the distribution of two specific atrazine (ATZ) oxidation products (desethyl-atrazine (DEA) and desisopropyl-atrazine (DIA)) was different in oxidation processes involving aqueous ferryl ion (Fe(IV)) species and •OH. Specifically, the molar ratio of produced DEA to DIA (i.e., [DEA]/[DIA]) increased from 7.5 to 13 with increasing pH from 3 to 6 when ATZ was oxidized by Fe(IV), while the treatment of ATZ by •OH led to the [DEA]/[DIA] value of 2 which was independent of pH. Moreover, ATZ showed high reactivity towards Fe(IV) over a wide pH range, especially at near-neutral pH, at which ATZ oxidation in Fe(II)/peroxydisulfate system was even much faster than another well-defined Fe(IV) scavenger, the sulfoxides. By using this approach, it was obtained that the [DEA]/[DIA] value remained at 2 during ATZ transformation by the nitrilotriacetic acid (NTA) assisted Fenton-like (Fe(III)/H2O2) system, which was independent of solution pH and reactants dosage. This result clarified that •OH was the primary reactive intermediate formed in the NTA assisted Fe(III)/H2O2 system. This study not only developed a novel sensitive diagnostic tool for distinguishing Fe(IV) from •OH, but also provided more credible evidence to the nature of reactive intermediate in a commonly controversial system.


Assuntos
Atrazina , Compostos Férricos , Peróxido de Hidrogênio , Ácido Nitrilotriacético , Oxirredução
15.
J Integr Plant Biol ; 63(10): 1695-1711, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34302720

RESUMO

Interactions and co-evolution between plants and herbivorous insects are critically important in agriculture. Brown planthopper (BPH) is the most severe insect of rice, and the biotypes adapt to feed on different rice genotypes. Here, we present genomics analyses on 1,520 global rice germplasms for resistance to three BPH biotypes. Genome-wide association studies identified 3,502 single nucleotide polymorphisms (SNPs) and 59 loci associated with BPH resistance in rice. We cloned a previously unidentified gene Bph37 that confers resistance to BPH. The associated loci showed high nucleotide diversity. Genome-wide scans for trans-species polymorphisms revealed ancient balancing selection at the loci. The secondarily evolved insect biotypes II and III exhibited significantly higher virulence and overcame more rice varieties than the primary biotype I. In response, more SNPs and loci evolved in rice for resistance to biotypes II and III. Notably, three exceptional large regions with high SNP density and resistance-associated loci on chromosomes 4 and 6 appear distinct between the resistant and susceptible rice varieties. Surprisingly, these regions in resistant rice might have been retained from wild species Oryza nivara. Our findings expand the understanding of long-term interactions between rice and BPH and provide resistance genes and germplasm resources for breeding durable BPH-resistant rice varieties.

16.
Chaos ; 31(5): 053111, 2021 May.
Artigo em Inglês | MEDLINE | ID: mdl-34240926

RESUMO

In this paper, the transient response of the time-delay system under additive and multiplicative Gaussian white noise is investigated. Based on the approximate transformation method, we convert the time-delay system into an equivalent system without time delay. The one-dimensional Ito stochastic differential equation with respect to the amplitude response is derived by the stochastic averaging method, and Mellin transformation is utilized to transform the related Fokker-Planck-Kolmogorov equation in the real numbers field into a first-order ordinary differential equation (ODE) of complex fractional moments (CFM) in the complex number field. By solving the ODE of CFM, the transient probability density function can be constructed. Numerical methods are used to ascertain the effectiveness of the CFM method, the effects of system parameters on system response and the level of error vary with time as well as noise intensity are investigated. In addition, the CFM method is first implemented to analyze transient bifurcation, and the relation between CFM and bifurcation is discussed for the first time. Furthermore, the imperfect symmetry property appear on the projection map of joint probability density function.

17.
Nanoscale ; 13(25): 11104-11111, 2021 Jul 07.
Artigo em Inglês | MEDLINE | ID: mdl-34132284

RESUMO

Three-dimensional (3D) TiO2 architectures have attracted significant attention recently as they can improve the electrochemical stability and realize the full potential of TiO2-based anodes in lithium ion batteries. Here, flower-like rutile TiO2 spheres with radially assembled nanorods (c-channels) were fabricated via a simple hydrothermal method. The 3D radial architecture affords massive active sites to fortify the lithium storage. Moreover, the presence of c-channels facilitates electrolyte infiltration and offers facile pathways for efficient Li+ transport. As a result, this flower-like rutile TiO2 anode gives significantly enhanced specific capacities (615 mA h g-1 at 1 C and 386 mA h g-1 at 2 C after 400 cycles) and a superior long-term cyclability (up to 10 000 cycles with a specific capacity of 67 mA h g-1 at 100 C). Kinetic analysis reveals that the enhanced diffusion-controlled and surface capacitive storage leads to the excellent electrochemical behavior. This work not only exhibits the enormous advantages of 3D architectures with c-channels, but also provides access to structural design and crystal phase selection for TiO2-based anode materials.

18.
Adv Mater ; 33(26): e2100746, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-33998706

RESUMO

Current therapeutic strategies for Alzheimer's disease (AD) treatments mainly focus on ß-amyloid (Aß) targeting. However, such therapeutic strategies have limited clinical outcomes due to the chronic and irreversible impairment of the nervous system in the late stage of AD. Recently, inflammatory responses, manifested in oxidative stress and glial cell activation, have been reported as hallmarks in the early stages of AD. Based on the crosstalk between inflammatory response and brain cells, a reactive oxygen species (ROS)-responsive dendrimer-peptide conjugate (APBP) is devised to target the AD microenvironment and inhibit inflammatory responses at an early stage. With the modification of the targeting peptide, this nanoconjugate can efficiently deliver peptides to the infected regions and restore the antioxidant ability of neurons by activating the nuclear factor (erythroid-derived 2)-like 2 signaling pathway. Moreover, this multi-target strategy exhibits a synergistic function of ROS scavenging, promoting Aß phagocytosis, and normalizing the glial cell phenotype. As a result, the nanoconjugate can reduce ROS level, decrease Aß burden, alleviate glial cell activation, and eventually enhance cognitive functions in APPswe/PSEN1dE9 model mice. These results indicate that APBP can be a promising candidate for the multi-target treatment of AD.

19.
Environ Sci Technol ; 55(11): 7711-7720, 2021 06 01.
Artigo em Inglês | MEDLINE | ID: mdl-34003010

RESUMO

Hydroxyl radicals (•OH) generated in the photocatalytic process are crucial to the conversion of methane (CH4) to value-added methanol (CH3OH) at room temperature. However, utilizing noble metal-free catalysts and low-energy photons of solar light, such as visible and near-infrared light (vis-NIR), is difficult to provide more electron states to form •OH radicals. Here, we developed FeOOH/Li0.1WO3 core-shell nanorods via a two-step in/out co-modification of hexagonal tungsten oxide (h-WO3): (1) lithium ions intercalating into the hexagonal tunnels of h-WO3 to form Li0.1WO3 nanorods and (2) using FeOOH-wrapped Li0.1WO3 to obtain FeOOH/Li0.1WO3 core-shell nanorods. Introduction of lithium induces polaron transition in Li0.1WO3, enabling the absorption of vis-NIR light. Interestingly, FeOOH-based Fenton-like reaction when H2O2 is selected as an oxidant favors the generation of more •OH radicals available for CH4 oxidation to CH3OH. Meanwhile, FeOOH with FeIII as an "electron sink" highly improves the separation of photoinduced electrons and holes in Li0.1WO3. Eventually, efficient selective formation of CH4OH is achieved with remarkable generation rates up to ∼342 and ∼160 µmol g-1 at visible light (420-700 nm) and NIR light (≥800 nm), respectively. Our finding opens up new possibilities for developing noble metal-free catalysts for solar energy-driven CH4 conversion to CH3OH under ambient conditions.


Assuntos
Metanol , Nanotubos , Compostos Férricos , Peróxido de Hidrogênio , Luz , Lítio , Metano
20.
J Phys Chem Lett ; : 4755-4761, 2021 May 13.
Artigo em Inglês | MEDLINE | ID: mdl-33983036

RESUMO

Black phosphorus (BP) is a typical two-dimensional (2D) layered material with strong in-plane anisotropy and large birefringence, making it possible to manipulate the light field with atomically controlled devices for various optoelectronic and photonic applications-for instance, atomic thickness waveplates. The twist angle in twisted black phosphorus (TBP) can be presented as a new tunable dimension to control BP's optical anisotropy. Here, we report a large and tunable optical rotation effect in TBP, the result of regulating the twist angle and BP thickness. To accurately study the optical rotation and the impact of the twist angle, we developed a new method to prepare TBP. A lab-made polarimeter microscope was used to visualize the optical rotation mapping of TBP. A large polarization-plane rotation (PORA) of 0.49° per atomic layer was observed from an air/BP/SiO2/Si Fabry-Pérot cavity at 600 nm, an order of magnitude higher than the PORA of 0.05° per atomic layer reported earlier. For the same thickness, the PORA of TBP can be tuned from 0.48° to 7.75° based on the twist angle from 0° to 90°. Our work provides an efficient method to investigate the anisotropy of 2D materials and their heterojunctions. TBP could help us design novel optical and optoelectronic devices such as tunable nanoscale polarization controllers.

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