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1.
Stem Cell Res Ther ; 11(1): 19, 2020 Jan 08.
Artigo em Inglês | MEDLINE | ID: mdl-31915074

RESUMO

Stem cell-derived sheet engineering has been developed as the next-generation treatment for myocardial infarction (MI) and offers attractive advantages in comparison with direct stem cell transplantation and scaffold tissue engineering. Furthermore, induced pluripotent stem cell-derived cell sheets have been indicated to possess higher potential for MI therapy than other stem cell-derived sheets because of their capacity to form vascularized networks for fabricating thickened human cardiac tissue and their long-term therapeutic effects after transplantation in MI. To date, stem cell sheet transplantation has exhibited a dramatic role in attenuating cardiac dysfunction and improving clinical manifestations of heart failure in MI. In this review, we retrospectively summarized the current applications and strategy of stem cell-derived cell sheet technology for heart tissue repair in MI.

2.
Ann Hematol ; 2020 Jan 04.
Artigo em Inglês | MEDLINE | ID: mdl-31900500

RESUMO

Many studies have confirmed that overexpressed WT1 exists in leukemic cells, especially in AML. However, the immunophenotypic features of this sort of leukemic cells remain to be unclarified. We retrospectively analyzed the immunophenotype of 283 newly diagnosed AML patients with intermediated and poor cytogenetic risk to evaluate the correlation between phenotype and WT1 overexpression. EVI1 transcripts, KMT2A-PTD, FLT3-ITD, and NPM1 mutations were simultaneously assessed. Our results revealed that overexpressed WT1 was significantly associated with the expression of CD117, CD13, and CD123. Besides, leukemic cells with WT1 overexpression also lacked lymphoid and myeloid differentiation-related markers. FAB subtype M2 patients had higher WT1 levels, compared with other FAB subtype. Multivariate analysis was proved that NPM1 mutation, M2 subtype, and the expression of CD123 were independently associated with WT1 overexpression. These indicated that AML with overexpressed WT1 was proliferated and blocked in the early stage of AML development. It presumably provided some clues to detect overexpressed WT1 cells via multiparameter flow cytometry. CD123-targeted drugs might become one of the alternative treatments for patients with WT1 overexpression.

3.
Chemistry ; 2020 Jan 07.
Artigo em Inglês | MEDLINE | ID: mdl-31912555

RESUMO

Multidrug resistance(MDR) is regarded as a main obstacle for effective chemotherapy, and P-glycoprotein(P-gp)-mediated drug efflux has demonstrated to be the key factor responsible for MDR. In this study, a novel pH-responsive hybrid drug delivery system was developed by conjugating D-α-tocopheryl polyethylene glycol 1000 succinate(TPGS), a kind of P-gp inhibitor, onto the surface of laponite nanodisks to efficiently deliver doxorubicin(DOX) to DOX-resistant breast cancer cells(MCF-7/ADR) by overcoming MDR. The prepared TPGS-modified laponite nanodisks(LM-TPGS) with high drug encapsulation efficiency display excellent colloidal stability and a pH-responsive drug release profile. In vitro experiments demonstrated that LM-TPGS/DOX could not only effectively inhibit the proliferation of MCF-7 as free DOX due to the efficient cell uptake of nanodisks and the synergistic effect of TPGS, but also exhibit significantly enhanced therapeutic efficacy in treating DOX-resistant MCF-7/ADR cells through inhibiting the activity of P-gp mediated drug efflux and effectively accumulating DOX within the cancer cells. Importantly, in vivo tumor inhibition results revealed that LM-TPGS/DOX performed outstanding suppression of MCF-7/ADR tumor and displayed low toxicity to heart. Therefore, the high payload of DOX, enhanced inhibition efficacy to drug-resistant cells, and the low side effect afford the LM-TPGS/DOX as a promising and effective nanoplatform to reverse MDR for effective chemotherapy.

4.
Chemistry ; 2020 Jan 09.
Artigo em Inglês | MEDLINE | ID: mdl-31917501

RESUMO

Here we report a heterostructure obtained by vacuum evaporation of a strong molecular n-dopant, [RuCp*(mes)]2, onto black phosphorus (BP) and the systematic investigation of the interfacial structure and properties by various in-situ characterization techniques. Ultraviolet photoelectron spectra (UPS) showed a large decrease in the work function of BP and a new peak within the bandgap, which is attributed to electron transfer from dopants to the underlying BP. The electrons trapped at the interface act as hole traps and induce photogating effect so that a photodetector based on BP-organoruthenium complex heterostructure demonstrates a photoresponsivity of 5.5 mA W-1 and an EQE of 1.3% at 515 nm, a tenfold improvement compared to the pristine BP device.

5.
Org Lett ; 2020 Jan 16.
Artigo em Inglês | MEDLINE | ID: mdl-31944780

RESUMO

ortho-Selective carbene C-H insertion of unprotected phenols is achieved with dimethyl diazomalonate under the catalysis of [Rh(COD)Cl]2. After the C-H insertion, subsequent cyclization and electrophilic addition of another carbene molecule affords tris-carboxylate-substituted 2-benzofuranones as the final reaction products. The enantioselective variant has been developed with the use of chiral diene ligands. Mechanistic experiments indicate that a transient oxonium ylide directing group might be responsible for the regiocontrol at the C-H activation step.

6.
J Phys Chem A ; 2020 Jan 17.
Artigo em Inglês | MEDLINE | ID: mdl-31951408

RESUMO

Understanding why crystallization in strong magnetic fields can lead to new polymorphs requires methods to calculate the diamagnetic response of organic molecular crystals. We develop the calculation of the macroscopic diamagnetic susceptibility tensor, χcryst, for organic molecular crystals using periodic density functional methods. The crystal magnetic susceptibility tensor, χcryst, for all experimentally known polymorphs, and its molecular counterpart, χmol, are calculated for flexible pharmaceuticals such as carbamazepine, flufenamic acid and chalcones, and rigid molecules, like benzene, pyridine, acridine, anthracene and coronene, whose molecular magnetic properties have been traditionally studied. A tensor addition method is developed to approximate the crystal diamagnetic susceptibility tensor, χcryst, from the molecular one, χmol, giving good agreement with those calculated directly using the more costly periodic density functional method for χcryst. The response of pharmaceutical molecules and crystals to magnetic fields, as embodied by χcryst, is largely determined by the packing in the crystal, as well as the molecular conformation. The anisotropy of χcryst can vary considerably between polymorphs though the isotropic terms are fairly constant. The implications for developing a computational method of predicting whether crystallization in a magnetic field could produce a novel or different polymorph are discussed.

7.
Artigo em Inglês | MEDLINE | ID: mdl-31941273

RESUMO

Stretchable conductive fibers have gained significant attention in the field of wearable and flexible electronics due to their inherited unique properties. Up to now, there are few reports regarding the highly stretchable fibers with excellent electricity properties. In this work, a highly stretchable fiber with superior electrical conductivity is fabricated, which contains a core fiber, an intermediate modified layer, and an outer eutectic gallium indium liquid metal layer. The fiber demonstrates excellent electrical conductivity of over 103 S cm-1 when stretched up to 500% strain, which is far superior to the existing stretchable conductive fiber. The stretchable conductive fiber shows excellent thermostability with a maximum operating temperature of nearly 250 oC. The unique fibers can be applied as highly stretchable, deformable conductor to charge a mobile phone and sensor to monitor human activities. This study offers promising application in the areas of flexible and wearable electronics.

8.
Nano Lett ; 2020 Jan 16.
Artigo em Inglês | MEDLINE | ID: mdl-31944125

RESUMO

Oxides heterostructure has attracted a lot of interests because of its rich exotic phenomena and potential applications. Recently, a greatly enhanced tunneling electroresistance (TER) of ferroelectric tunnel junctions (FTJs) has been realized in such heterostructures. However, our understanding on the electronic structure of resistance response with polarization reversal and the origin of huge TER are still lacking. Here, we report on electronic structures, particularly at the interface and surface, and the control of the spontaneous polarization of BaTiO3 films by changing the termination of a SrTiO3 substrate. Interestingly, unusual electron and hole midgap states are concurrently formed and accompanied by orbital reconstructions, which determine the ferroelectric polarization orientation in the BaTiO3/SrTiO3. Such unusual midgap states, which yield a strong electronic screening effect, reduce the ferroelectric barrier width and height, and pin the ferroelectric polarization, lead to a dramatic enhancement of the TER effect. The midgap states are also observed in BaTiO3 films on electron-doped Nb:SrTiO3 revealing its universality. Our result provides new insight into the origin of the huge TER effect and opens a new route for designing ferroelectric tunnel junctions-based devices with huge TER through interface engineering.

9.
Oncol Rep ; 43(2): 591-600, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31894331

RESUMO

Mutation of the p53 tumor suppressor frequently occurs in lung cancer, and can be as high as 75­90% in small­cell lung cancer. Mutant p53 (mtp53) can inhibit the wild­type p53 protein, disrupting its tumor suppressor functions. In addition, mutant p53 often acquires the functions of an oncogene. Post­translational modification of the p53 protein is important for its transcriptional and tumor suppressive functions. We previously revealed that high levels of mutant p53 expression were associated with reduced expression of the deacetylation enzyme sirtuin 3 (SIRT3) in lung cancer tissues. Given this negative correlation between p53 and SIRT3 expression, and given that SIRT3 is a deacetylase, we speculated that SIRT3 participates in the post­translational modification of mutant p53, regulating its stability and function, thereby inhibiting the growth of lung cancer cells. Light microscopy, MTT and flow cytometric assays revealed that SIRT3 overexpression inhibited growth and promoted apoptosis in NCI­H446 human small cell lung cancer cells. SIRT3 overexpression also resulted in necroptosis, and this could be partially reversed following cell treatment with the necroptosis inhibitor necrostatin­1 (Nec­1), which could restore certain cells to survive. Western blotting assays revealed that SIRT3 overexpression resulted in the reduced expression and half­life of mutant p53, indicating that SIRT3 decreases mutant p53 stability. Proteasome inhibitor experiments revealed that the decrease in mutant p53 stability was a result of increased proteasomal degradation of the protein. Immunoprecipitation studies revealed that ubiquitination of mutant p53 was elevated in SIRT3­overexpressing cells, indicating that SIRT3 affected ubiquitination­mediated protein degradation. In the present study, it was therefore revealed that SIRT3 can inhibit the growth of human small­cell lung cancer cells by promoting apoptosis and necroptosis. It was also revealed that SIRT3 expression could regulate the stability of mutant p53 by controlling ubiquitination­mediated proteasomal degradation of the protein. SIRT3 expression may therefore play an important role in the growth of mutant p53­associated lung cancer.

10.
Sci Rep ; 10(1): 23, 2020 Jan 08.
Artigo em Inglês | MEDLINE | ID: mdl-31913350

RESUMO

Diabetes mellitus (DM) significantly increases myocardial ischemia/reperfusion (MI/R) injury. During DM, cardioprotection induced by conventional pre-conditioning (PreCon) is decreased due to impaired AMP-activated protein kinase (AMPK) signaling. The current study investigated whether PreCon with inhaled anesthetic sevoflurane (SF-PreCon) remains cardioprotective during DM, and identified the involved mechanisms. Normal diet (ND) and high-fat diet (HFD)-induced DM mice were randomized into control and SF-PreCon (3 cycles of 15-minute period exposures to 2% sevoflurane) groups before MI/R. SF-PreCon markedly reduced MI/R injury in DM mice, as evidenced by improved cardiac function (increased LVEF and ±Dp/dt), decreased infarct size, and decreased apoptosis. To determine the relevant role of AMPK, the effect of SF-PreCon was determined in cardiac-specific AMPKα2 dominant negative expressing mice (AMPK-DN). SF-PreCon decreased MI/R injury in AMPK-DN mice. To explore the molecular mechanisms responsible for SF-PreCon mediated cardioprotection in DM mice, cell survival molecules were screened. Interestingly, in ND mice, SF-PreCon significantly reduced MI/R-induced activation of p38, a pro-death MAPK, without altering ERK and JNK. In DM and AMPK-DN mice, the inhibitory effect of SF-PreCon upon p38 activation was significantly blunted. However, SF-PreCon significantly increased phosphorylation of ERK1/2, a pro-survival MAPK in DM and AMPK-DN mice. We demonstrate that SF-PreCon protects the heart via AMPK-dependent inhibition of pro-death MAPK in ND mice. However, SF-PreCon exerts cardioprotective action via AMPK-independent activation of a pro-survival MAPK member in DM mice. SF-PreCon may be beneficial compared to conventional PreCon in diabetes or clinical scenarios in which AMPK signaling is impaired.

11.
J Colloid Interface Sci ; 565: 70-76, 2020 Jan 07.
Artigo em Inglês | MEDLINE | ID: mdl-31935586

RESUMO

Fluorinated graphene (F-GNS) was synthesized using commercial graphene (GNS) as starting material and introduced in sodium batteries, which exhibited good rate performance, but large voltage gap between discharge and charge process. Ag nanoparticles were employed in freestanding and binder-free F-GNS electrode (the composite film electrode was labeled as FGA) as catalyst, which were shown to strongly facilitate the decomposition of NaF during charge process in sodium/carbon fluorides (Na/CFx) secondary batteries. During discharge process, the discharge voltage with Ag was about the same as that of Na/F-GNS cell. During charge process, the charge voltage of Na/FGA cell was substantially lower (by 480 mV) than that of Na/F-GNS cell, thus leading to a lower overpotential and a higher electric efficiency. Nanosized amorphous discharge products of NaF formed in Na/FGA cells were ascribed as the key role in reducing the polarization.

12.
Pharmacol Res ; 152: 104627, 2020 Jan 02.
Artigo em Inglês | MEDLINE | ID: mdl-31904505

RESUMO

Traditional Chinese medicine (TCM) has been broadly used for the personalized treatment of many diseases in China for thousands of years. In the past century, TCM was also introduced to other Asian countries and even the Western world. Increasing evidence has shown that TCM has the capacity to treat numerous complex diseases in the clinic, such as cardiovascular diseases (CVDs), infectious diseases, metabolic diseases, and neurodegenerative diseases. However, the earlier lack of analytical strategies to annotate the chemical complexity has severely impeded the modern study and translational application of TCM. This critical review aims to explore and exploit applications of systems biology-driven omics methods in TCM against a diversity of diseases, toward the specific use of TCM to treat patients with different diseases. Such effort shall enhance the applicability of systems biology-driven omics strategies in deciphering the mechanisms by which TCM treats different diseases and may lead to the discovery of new therapeutic directions. In addition, we proposed the possible strategies to innovate the applicable pattern of omics technologies in TCM niches, such as precision-modification metabolomics and chinmedomics methods, allowing to unveil the complexity of TCM, which must enable TCM to serve better for the population-health. Taken together, this review eventually shall highlight the core value of omics technologies in innovating TCM to combat the diseases in a new horizon.

13.
Huan Jing Ke Xue ; 41(1): 205-212, 2020 Jan 08.
Artigo em Chinês | MEDLINE | ID: mdl-31854921

RESUMO

We explored the pollution characteristics, spatial and temporal distribution, ecological risk, and human health risk of organophosphate esters (OPEs) in the source water of the Nanjing section of the Yangtze River. Thirteen OPEs were determined by solid phase extraction-high performance liquid chromatography-tandem mass spectrometry. The results showed that twelve OPEs were detected to different extents with total concentrations ranging from 85.21 to 1557.96 ng·L-1[excluding tris (2,3-dibromopropyl) phosphate]. Chloroalkyl phosphate was the main compound and tris(2-chloroethyl) phosphate (TCEP) was the most abundant of the thirteen OPEs, which reached up to 447.08 ng·L-1. Seasonal variation of OPEs showed that the concentrations of OPEs in summer ranged from 220-1557.96 ng·L-1, with the average concentration of 493.78 ng·L-1 being 1.7-2.6 times higher than of that in spring and autumn. An ecological risk assessment showed that tricresyl phosphate and 2-ethylhexyl diphenyl phosphate were associated with moderate or high risks to organisms (algae, crustaceans, and fish). At a high exposure concentration, the total non-carcinogenic risk of OPEs in source water ranged from 4.41×10-3-2.91×10-2, with the highest risk being associated with children aged 0-3 months. The total cancer risk value was 5.88×10-7-3.89×10-6, among which TCEP and Tris(1,3-dichloro-2-propyl) phosphate was associated with a potential risk for children. We conclude that the long-term exposure risk for children of OPEs in the source water of the Nanjing section of the Yangtze River deserve more attention.


Assuntos
Monitoramento Ambiental , Retardadores de Chama/análise , Organofosfatos/análise , Rios/química , Poluentes Químicos da Água/análise , Animais , China , Ésteres/análise , Humanos , Lactente , Recém-Nascido , Medição de Risco , Estações do Ano
14.
ACS Appl Mater Interfaces ; 12(2): 3236-3244, 2020 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-31869208

RESUMO

Interfacial bonding and adhesion mechanisms are important in determining the final properties of the polymer composite. Molecular dynamics (MD) simulations have been used to characterize the interfacial structure and adhesion behavior of crystalline cellulose planes in contact with polylactic acid. The structure of the PLA at the interface exhibits a shape that can accommodate the structure of the cellulose surface. The adhesion between the PLA and the cellulose surface is affected by the polarity of the functional groups and the surface roughness. The improved adhesion is primarily due to hydrogen bonds formed between the cellulose and PLA molecular chains. Cellulose planes with higher molecular protrusions and greater surface roughness produce stronger adhesion to PLA due to enhanced hydrogen bonding. This study provides a basic insight into the interfacial mechanisms of PLA and cellulose surfaces at the molecular level.

15.
Proc Natl Acad Sci U S A ; 117(1): 73-79, 2020 Jan 07.
Artigo em Inglês | MEDLINE | ID: mdl-31848237

RESUMO

Lithium is the most attractive anode material for high-energy density rechargeable batteries, but its cycling is plagued by morphological irreversibility and dendrite growth that arise in part from its heterogeneous "native" solid electrolyte interphase (SEI). Enriching the SEI with lithium fluoride (LiF) has recently gained popularity to improve Li cyclability. However, the intrinsic function of LiF-whether chemical, mechanical, or kinetic in nature-remains unknown. Herein, we investigated the stability of LiF in model LiF-enriched SEIs that are either artificially preformed or derived from fluorinated electrolytes, and thus, the effect of the LiF source on Li electrode behavior. We discovered that the mechanical integrity of LiF is easily compromised during plating, making it intrinsically unable to protect Li. The ensuing in situ repair of the interface by electrolyte, either regenerating LiF or forming an extra elastomeric "outer layer," is identified as the more critical determinant of Li electrode performance. Our findings present an updated and dynamic picture of the LiF-enriched SEI and demonstrate the need to carefully consider the combined role of ionic and electrolyte-derived layers in future design strategies.

16.
Restor Neurol Neurosci ; 37(6): 571-581, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31796710

RESUMO

 Many ocular diseases (such as glaucoma, diabetic retinopathy, age-related macular degeneration, and traumatic eye injuries) can result in the degeneration of retinal cells and the subsequent loss of vision. Some kinds of treatments, such as drugs, stem cell transplantation and surgery are reported to be effective in certain patients. However, no confirmatively effective, convenient and low-price intervention has been available so far. Physical exercise has been reported to exert neuroprotective effects on several neurodegenerative diseases, including Parkinson's disease and Alzheimer's disease. Studies investigating the potential impacts of exercise on retinal diseases are rapidly emerging. Here we review these up-to-date findings from both human and animal studies, and discuss the possible mechanisms underlying exercise-elicited protection on retina.

17.
Clin Neurol Neurosurg ; 189: 105616, 2019 Nov 20.
Artigo em Inglês | MEDLINE | ID: mdl-31809890

RESUMO

OBJECTIVE: Seizures are common complications following intracranial aneurysms and present a greater risk to pediatric patients than adults. Though the risk factors of seizures in adults with intracranial aneurysms have been well documented, the risk factors in pediatric patients remain unknown. The aim of this study was to evaluate the risk factors for preoperative seizures and the effect of the treatment approach on postoperative seizures in pediatric patients with intracranial aneurysms. PATIENTS AND METHODS: The data of 64 pediatric patients (mean age 11.4 ± 5.7 years; 68.8 % of males) with intracranial aneurysms were retrospectively analyzed from January 2012 to April 2017. Comparisons were made between patients with preoperative seizures (case group) and those without (control group). RESULTS: Twenty-four patients (37.5 %) had preoperative seizures, and 15 patients (23.4 %) had postoperative seizures. Multiple logistic regression analysis revealed that younger age (0-5 years), head trauma history, ruptured aneurysms, lobe hematomas, modified Fisher grade 3-4, giant aneurysms, pseudoaneurysms and distal arterial aneurysms were independently associated with the increased risk of preoperative seizures. Patients in the surgical and endovascular groups did not differ significantly in the rates of preoperative seizures or early postoperative seizures (within 1 month) (P > 0.05). However, a significantly lower incidence of late postoperative seizures (1-3 months and 3-6 months) was observed in the surgical group compared with the endovascular group (P < 0.05). CONCLUSION: Pediatric patients with intracranial aneurysms are at high risk for seizures. Risk factors for preoperative seizures included younger age (0-5 years), head trauma history, lobe hematomas, modified Fisher grade 3-4, giant aneurysms, pseudoaneurysms and distal arterial aneurysms. Compared with the endovascular treatment, surgical intervention provided more benefits with regard to reducing the risk of late postoperative seizures.

18.
Mil Med Res ; 6(1): 38, 2019 Dec 09.
Artigo em Inglês | MEDLINE | ID: mdl-31813379

RESUMO

BACKGROUND: When lowlanders rapidly ascend to altitudes > 2500 m, they may develop acute mountain sickness (AMS). The individual susceptibility, ascending velocity, time spent at altitude, activity levels and altitude reached are considered risk factors for AMS. However, it is not clear whether sex is a risk factor. The results have been inconclusive. We conducted a meta-analysis to test whether there were sex-based differences in the prevalence of AMS using Lake Louise Scoring System. METHODS: Systematic searches were performed in August 2019 in EMBASE, PubMed, and Web of Science for prospective studies with AMS data for men and women. The titles and abstracts were independently checked in the primary screening step, and the selected full-text articles were independently assessed in the secondary screening step by the two authors (YPH and JLW) based on pre-defined inclusion criteria. The meta-analysis was performed using by the STATA 14.1 software program. A random-effects model was employed. RESULTS: Eighteen eligible prospective studies were included. A total of 7669 participants (2639 [34.4%] women) were tested. The results showed that there was a statistically significant higher prevalence rate of AMS in women than in men (RR = 1.24, 95%CI 1.09-1.41), regardless of age or race. Howerver, the heterogeneity was significant in the analysis (Tau2 = 0.0403, Chi2 = 50.15, df = 17; I2 = 66.1%, P = 0.000), it was main caused by different numbers of subjects among the studies (coefficient = - 2.17, P = 0.049). Besides, the results showed that there was no evidence of significant publication bias in the combined studies on the basis of Egger's test (bias coefficient = 1.48, P = 0.052) and Begg's test (P = 0.130). CONCLUSIONS: According to this study, the statistically significant finding emerging from this study was that women have a higher prevalence of AMS. However, the authors could not exclude studies where patients were on acetazolamide. Our analysis provided a direction for future studies of the relationship of sex and the risk of AMS, such as the pathological mechanism and prevention research.

19.
Protein Cell ; 2019 Dec 09.
Artigo em Inglês | MEDLINE | ID: mdl-31814083

RESUMO

The author would like to add the below information in this correction. A similar study from Chao Lu group was published online on 5 September 2019 in Nature, entitled "The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape" (Weinberg et al., 2019). Although both the studies reported the preferential recognition of H3K36me2 by DNMT3A PWWP, ours in addition uncovered a stimulation function by such interaction on the activity of DNMT3A. On the disease connections, we used a NSD2 gain-of-function model which led to the discovery of potential therapeutic implication of DNA inhibitors in the related cancers, while the other study only used NSD1 and DNMT3A loss-of-function models.

20.
Int J Hyperthermia ; 36(1): 1197-1206, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31814458

RESUMO

Purpose: This study aimed to evaluate the immediate efficacy of magnetic resonance (MR)-guided microwave ablation (MWA) in rabbit kidneys implanted with VX2 tumors.Materials and methods: MR-guided MWA was performed in eight VX2 tumor-bearing rabbits. MR images after ablation were obtained and analyzed. The differences between the tissue specimens and MR images obtained after ablation were compared.Results: On the three-dimensional volumetric interpolated breath-hold T1-weighted (3D-VIBE-T1WI) sequence, a low signal intensity indicated the primary tumor at the center of the ablation area, which was surrounded by a peripheral high-signal area. The signal for the primary tumor in the fast spin-turbo spin-echo T2-weighted (FS-TSE-T2WI) sequence was lower than before, and the ablation zone showed a low signal that completely covered the primary tumor. There was no significant difference in volume among the low-signal areas of the primary tumor on FS-TSE-T2WI before MWA, the central low-signal area on 3D-VIBE-T1WI after MWA, and the tumor coagulation necrosis area on the tissue specimens (p > 0.05). No significant difference was found in the volume of ablation zones among the tissue specimens, the high-signal area around the lesion on the 3D-VIBE-T1WI sequence, and the low-signal area covering the lesion on the FS-TSE-T2WI sequence (p > 0.05).Conclusion: Magnetic resonance imaging (MRI) is an effective method for immediate efficacy evaluation of rabbit renal VX2 tumors after MWA and can serve as a valuable reference for the clinical assessment of post-ablative renal tumors.

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