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1.
J Hazard Mater ; 423(Pt A): 127053, 2022 Feb 05.
Artigo em Inglês | MEDLINE | ID: mdl-34523495

RESUMO

Nickel@MXene quantum dots (Ni@MQDs), as novel flower-like hybrid materials, were firstly prepared through a simple reduction method. The Ni@MQDs exhibited an outstanding catalytic performance for Cr (VI) reduction with a low activation energy (Ea = 18.9 kJ mol-1) and a high kinetic constant (k = 0.4779 min-1) in the presence of formic acid (HCOOH). Density functional theory calculations demonstrated that Ni@MQDs exhibited an upshift of d-band center of active Ni atoms to promote the adsorption of both HCOOH and active H atoms, as well as an improved conductivity to boost the catalytic reaction kinetics, leading to the most favorable catalytic performance. This work may open up a new avenue towards the design and synthesis of novel MQDs-based hybrid catalysts for wastewater treatment.

3.
Comput Math Methods Med ; 2021: 7922594, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34646338

RESUMO

Background: Idiopathic Pulmonary Fibrosis (IPF) is one of the most common idiopathic interstitial pneumonia, which can occur all over the world. The median survival time of patients is about 3-5 years, and the mortality is relatively high. Objective: To reveal the potential molecular characteristics of IPF and deepen the understanding of the molecular mechanism of IPF. In order to provide some guidance for the clinical treatment, new drug development, and prognosis judgment of IPF. Although the preliminary conclusion of this study has certain guiding significance for the treatment of IPF and so on, it needs more accurate analytical approaches and large sample clinical trials to verify. Methods: 220 patients with IPF were divided into different subgroups according to the gene expression profiles, which were obtained from the Gene Expression Omnibus (GEO) database. In addition, these subgroups present different expression forms and clinical features. Therefore, weighted gene coexpression analysis (WGCNA) was used to seek the differences between subtypes. And six subgroup-specific WGCNA modules were identified. Results: Combined with the characteristics of WGCNA and KEGG enrichment modules, the autophagic pathway was only upregulated in subgroup I and enriched significantly. The differentiation pathways of Th1 and Th2 cells were only upregulated and enriched in subgroup II. At the same time, combined with clinical information, IPF patients in subgroup II were older and more serious, which may be closely related to the differentiation of Th1 and Th2 cells. In contrast, the neuroactive ligand-receptor interaction pathway and Ca+ signaling pathway were significantly upregulated and enriched in subgroup III. Although there was no significant difference in prognosis between subgroup I and subgroup III, their intrinsic biological characteristics were very different. These results suggest that the subtypes may represent risk factors of age and intrinsic biological characteristics and may also partly reflect the severity of the disease. Conclusion: In conclusion, current studies have improved our understanding of IPF-related molecular mechanisms. At the same time, because the results show that patients from different subgroups may have their own unique gene expression patterns, it reminds us that patients in each subgroup should receive more personalized treatment.


Assuntos
Fibrose Pulmonar Idiopática/classificação , Fibrose Pulmonar Idiopática/genética , Estudos de Casos e Controles , Biologia Computacional , Bases de Dados Genéticas , Feminino , Perfilação da Expressão Gênica/estatística & dados numéricos , Humanos , Masculino , Anotação de Sequência Molecular , Análise de Componente Principal , Prognóstico
4.
Artigo em Inglês | MEDLINE | ID: mdl-34545025

RESUMO

Metformin is the first-choice oral anti-hyperglycemic drug for type 2 diabetes mellitus (T2DM) patients. There are controversies about the association of SLC22A1 rs622342, which was not reported in the Chinese population, and ataxia-telangiectasia mutated (ATM) rs11212617 polymorphisms with metformin efficacy in T2DM. Our study was to investigate the effects of the two single nucleotide polymorphisms on the efficacy of metformin in T2DM of Han nationality in Chaoshan China. After enrollment, 82 newly diagnosed T2DM patients went on 2-month metformin monotherapy. According to BMI before treatment, the patients were divided into a normal weight group (≥18.5 and <25 kg/m2) and an overweight group (BMI ≥ 25 and <30 kg/m2). T-test, Pearson χ2 test, and regression analysis, which adjusted for age, BMI, sex, the dose of metformin, education, tea drink, smoking, and sweet, were used to evaluate the effects of rs622342 and rs11212617 on several variables, such as fasting plasma glucose (FPG). Compared with the AA or CC genotype, patients with AC genotype of rs622342 achieved greater reduction in Δ60FPG and Δ(60-30)FPG (P = 0.00820, 0.00089, respectively). For 11212617, the reduction in Δ30FPG and Δ60FPG was significantly different among patients with the AC genotype (P = 0.00026, 0.00820, respectively). Our results indicated that common variants of SLC22A1 rs622342 and ATM rs11212617 were associated with the efficacy of metformin in T2DM of Han nationality in Chaoshan China.

5.
Hum Mol Genet ; 2021 Sep 30.
Artigo em Inglês | MEDLINE | ID: mdl-34590683

RESUMO

BACKGROUND: Activated neutrophil-derived exosomes reportedly contribute to the proliferation of airway smooth muscle cells (ASMCs), thereby aggravating the airway wall remodeling during asthma; however, the specific mechanism remains unclear. METHODS: Lipopolysaccharide (LPS)-EXO and si-CRNDE-EXO were extracted from the media of human neutrophils treated with LPS and LPS + si-CRNDE (a siRNA targets long non-coding RNA CRNDE), respectively. Human ASMCs were co-cultured with LPS-EXO or si-CRNDE-EXO, and cell viability, proliferation, and migration were measured. The interplay of CRNDE, inhibitor of nuclear factor kappa B kinase subunit beta (IKKß), and nuclear receptor subfamily 2 group C member 2 (TAK1) was explored using RNA immunoprecipitation (RIP) and Co-IP assays. A mouse model of asthma was induced using ovalbumin. RESULTS: CRNDE was upregulated in LPS-EXO and successfully transferred from LPS-treated neutrophils to ASMCs through exosome. Mechanically, CRNDE loaded in LPS-EXO reinforced TAK1-mediated IKKß phosphorylation, thereby activating the nuclear factor kappa B (NF-κB) pathway. Functionally, silencing CRNDE in LPS-EXO, an IKKß inhibitor, and an NF-κB inhibitor all removed the upregulation of cell viability, proliferation, and migration induced by LPS-EXO in ASMCs. In the end, the in vivo experiment demonstrated that CRNDE knockdown in neutrophils effectively reduced the thickness of bronchial smooth muscle in a mouse model for asthma. CONCLUSION: Activated neutrophils-derived CRNDE was transferred to ASMCs through exosomes and activated the NF-κB pathway by enhancing IKKß phosphorylation. The latter promoted the proliferation and migration of ASMCs and then contributed to airway remodeling in asthma.

6.
Zhongguo Dang Dai Er Ke Za Zhi ; 23(9): 927-932, 2021.
Artigo em Inglês, Chinês | MEDLINE | ID: mdl-34535208

RESUMO

OBJECTIVES: To study the association of animal protein diet with the recurrence of Henoch-Schönlein purpura (HSP)/skin rash and the risk factors for recurrence of HSP. METHODS: A prospective analysis was performed for 121 children with HSP who were admitted to the Beijing Children's Hospital from October to December 2020. The children were given the doctor's advice of the same diet (animal protein diet could be added after 1 week without new-onset skin rash). Follow-up was performed at the outpatient service for half a year. According to the presence or absence of animal protein intake, the children were divided into an observation group with 65 children and a control group with 56 children. The times of skin rash recurrence, the incidence of HSP recurrence, and the incidence of kidney injury were compared between the two groups. According to the presence or absence of recurrence, the children were divided into a recurrence group with 32 children and a non-recurrence group with 89 children. A questionnaire on food frequency was used to record the daily intake of animal protein in the two groups. A multivariate logistic regression analysis was used to identify the risk factors for recurrence of HSP in children. RESULTS: There was no significant difference between the observation and control groups in the times of skin rash recurrence, the incidence rate of HSP recurrence, and the incidence rate of kidney injury (P>0.05). There was no significant difference in the daily intake of animal protein between the recurrence and non-recurrence groups (P>0.05). The multivariate logistic regression analysis showed that presence of kidney injury at initial onset, respiratory infection after cure for the first time, and lack of exercise control after cure for the first time were independent risk factors for the recurrence of HSP in children (P<0.05). CONCLUSIONS: There is no significant association between animal protein diet and the recurrence of HSP or skin rash. Timely treatment of kidney injury, avoidance of infection after cure, and limitation of strenuous exercise may help to reduce the recurrence rate of HSP in children. Citation.


Assuntos
Púrpura de Schoenlein-Henoch , Animais , Dieta , Humanos , Rim , Prognóstico , Fatores de Risco
7.
Chem Commun (Camb) ; 57(77): 9930-9933, 2021 Sep 28.
Artigo em Inglês | MEDLINE | ID: mdl-34498632

RESUMO

We demonstrate that MoS2 quantum dots (QDs) can be an effective and durable catalyst for the electrocatalytic N2 reduction reaction (NRR), showing an NH3 yield of 39.6 µg h-1 mg-1 with a faradaic efficiency of 12.9% at -0.3 V, far superior to MoS2 nanosheets and outperforming most reported NRR catalysts. Density functional theory computations unravel that the MoS2 QDs can dramatically facilitate N2 adsorption and activation via side-on patterns, resulting in an energetically-favored enzymatic pathway with an ultra-low overpotential of 0.29 V.

8.
Small ; 17(40): e2102363, 2021 10.
Artigo em Inglês | MEDLINE | ID: mdl-34499407

RESUMO

Electrochemical N2 fixation represents a promising strategy toward sustainable NH3 synthesis, whereas the rational design of high-performance catalysts for the nitrogen reduction reaction (NRR) is urgently required but remains challenging. Herein, a novel hexagonal BN quantum dots (BNQDs) decorated Nb2 CTx -MXene (BNQDs@Nb2 CTx ) is explored as an efficient NRR catalyst. BNQDs@Nb2 CTx presents the optimum NRR activity with an NH3 yield rate of 66.3 µg h-1 mg-1 (-0.4 V) and a Faradaic efficiency of 16.7% (-0.3 V), outperforming most of the state-of-the-art NRR catalysts, together with an excellent stability. Theoretical calculations revealed that the synergistic interplay of BNQDs and Nb2 CTx enabled the creation of unique interfacial B sites serving as NRR catalytic centers capable of enhancing the N2 activation, lowering the reaction energy barrier and impeding the H2 evolution.


Assuntos
Pontos Quânticos , Compostos de Boro , Nióbio , Nitrogênio , Tomografia Computadorizada por Raios X
9.
Sci Total Environ ; 801: 149609, 2021 Dec 20.
Artigo em Inglês | MEDLINE | ID: mdl-34419907

RESUMO

Sewage sludge was rich in pollutants such as heavy metals, nutrients and persistent organic pollutants. Anaerobic digestion can effectively degrade the pollutants while achieving sludge stabilization and reduction. This study took a sludge treatment plant located in Anhui Province, China as a case study, investigating the variations of multiple substances and particle size distribution during sludge anaerobic digestion-solar drying-land utilization process. The results demonstrated anaerobic digestion had a positive effect on the removal of heavy metals, nutrients and persistent organic pollutants, for polycyclic aromatic hydrocarbons, antibiotics and disinfection by-products with 41.38%, 62.26% and 68.68%, respectively, which were related to their molecular weight and structure. Large amounts of heavy metals would flow away with liquid digestate, in which Cr and Hg were the most and least, 90.44% and 41.95% respectively. The degradation of extracellular polymers in this process led to a decrease in particle size distribution, which caused the deterioration of sludge dewatering performance. Nutrients and water content increased and decreased respectively during solar drying along with the volatilization of organic matter under high temperature, which was beneficial for the final sludge product to subsequent land utilization. No significant correlation was demonstrated between heavy metals and sludge properties besides electrical conductivity. The study provided a new thinking on the variations of different substances and the way of actual treatment and disposal from the perspective of sludge anaerobic digestion-solar drying-land utilization process, which had a considerable significance for the further promotion and application of anaerobic digestion process in China's engineering community.


Assuntos
Metais Pesados , Esgotos , Anaerobiose , Nutrientes , Tamanho da Partícula , Eliminação de Resíduos Líquidos
10.
Chaos ; 31(1): 011104, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-33754764

RESUMO

Can a neural network trained by the time series of system A be used to predict the evolution of system B? This problem, knowing as transfer learning in a broad sense, is of great importance in machine learning and data mining yet has not been addressed for chaotic systems. Here, we investigate transfer learning of chaotic systems from the perspective of synchronization-based state inference, in which a reservoir computer trained by chaotic system A is used to infer the unmeasured variables of chaotic system B, while A is different from B in either parameter or dynamics. It is found that if systems A and B are different in parameter, the reservoir computer can be well synchronized to system B. However, if systems A and B are different in dynamics, the reservoir computer fails to synchronize with system B in general. Knowledge transfer along a chain of coupled reservoir computers is also studied, and it is found that, although the reservoir computers are trained by different systems, the unmeasured variables of the driving system can be successfully inferred by the remote reservoir computer. Finally, by an experiment of chaotic pendulum, we demonstrate that the knowledge learned from the modeling system can be transferred and used to predict the evolution of the experimental system.

11.
J Exp Clin Cancer Res ; 40(1): 42, 2021 Jan 25.
Artigo em Inglês | MEDLINE | ID: mdl-33494784

RESUMO

Recent scientific advances have greatly enhanced our understanding of the complex link between the gut microbiome and cancer. Gut dysbiosis is an imbalance between commensal and pathogenic bacteria and the production of microbial antigens and metabolites. The immune system and the gut microbiome interact to maintain homeostasis of the gut, and alterations in the microbiome composition lead to immune dysregulation, promoting chronic inflammation and development of tumors. Gut microorganisms and their toxic metabolites may migrate to other parts of the body via the circulatory system, causing an imbalance in the physiological status of the host and secretion of various neuroactive molecules through the gut-brain axis, gut-hepatic axis, and gut-lung axis to affect inflammation and tumorigenesis in specific organs. Thus, gut microbiota can be used as a tumor marker and may provide new insights into the pathogenesis of malignant tumors.


Assuntos
Transformação Celular Neoplásica , Suscetibilidade a Doenças , Microbioma Gastrointestinal , Sistema Imunitário/imunologia , Sistema Imunitário/metabolismo , Neoplasias/etiologia , Neoplasias/metabolismo , Animais , Biomarcadores , Disbiose , Humanos , Proteínas de Checkpoint Imunológico/genética , Proteínas de Checkpoint Imunológico/metabolismo , Inflamassomos/imunologia , Inflamassomos/metabolismo , Neoplasias/patologia , Neoplasias/terapia
12.
J Tradit Chin Med ; 40(5): 803-811, 2020 10.
Artigo em Inglês | MEDLINE | ID: mdl-33000581

RESUMO

OBJECTIVE: To investigate synergistic effect of Reduning (RDN) injection plus ribavirin against severe pneumonia induced by H1N1 influenza A virus in mice. METHODS: We established a mouse model of severe pneumonia induced by influenza A virus by infecting Balb/c mice with CA07 virus. We randomly assigned the infected mice into four groups, and treated them with normal saline (NS group), RDN (injection, 86.6 mg/kg), ribavirin (injection, 66.6 mg/kg) or double Ribavirin plus RDN group, the same dosage as used in the single treatments) for 5 d. Lung index and lung pathology were recorded or calculated in terms of the curative effective. Cytokines, NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome related protein including caspase-associated recruitment domain (CARD) domain Apoptosis-associated speck-like protein containing a caspase recruitment domain(ASC), caspase-1 and NOD-like receptor family, pyrin domain containing 3 (NLRP3), and reactive oxygen species were simultaneously investigated. RESULTS: RDN plus ribavirin treatment, not RDN or ribavirin alone, provided a significant survival benefit to the influenza A virus-infected mice. The combination treatment protected the mice against severe influenza infection by attenuating the severe lung injury. The combined treatment also reduced the viral titers in mouse lungs and lung index, downregulated their immunocytokine levels, including IL-1ß and IL-18, and down regulated the NLRP3, especially the transcription and translation of caspase-1. Meanwhile NS group had significantly higher reactive oxygen species (ROS) expression which could was dramatically reduced by the treatment of RDN plus ribavirin. CONCLUSION: Our study showed that RDN combined with ribavirin could protect the mice, and reduce the lung immunopathologic damage caused by severe influenza pneumonia. The mechanism could be that it reduced ROS produce and inhibited NLRP3 inflammasome activation so that mainly lower the downstream inflammatory cytokines IL-1ß and IL-18.


Assuntos
Medicamentos de Ervas Chinesas/administração & dosagem , Vírus da Influenza A Subtipo H1N1/fisiologia , Pneumonia/tratamento farmacológico , Ribavirina/administração & dosagem , Animais , Sinergismo Farmacológico , Quimioterapia Combinada , Feminino , Humanos , Vírus da Influenza A Subtipo H1N1/genética , Influenza Humana/complicações , Influenza Humana/virologia , Interleucina-1beta/genética , Interleucina-1beta/imunologia , Interleucina-8/genética , Interleucina-8/imunologia , Pulmão/imunologia , Pulmão/virologia , Camundongos , Camundongos Endogâmicos BALB C , Proteína 3 que Contém Domínio de Pirina da Família NLR/genética , Proteína 3 que Contém Domínio de Pirina da Família NLR/imunologia , Pneumonia/etiologia , Pneumonia/genética , Pneumonia/imunologia
13.
Chem Commun (Camb) ; 56(85): 13009-13012, 2020 Oct 27.
Artigo em Inglês | MEDLINE | ID: mdl-32996944

RESUMO

ZrB2 is first explored as an earth-abundant metal diboride catalyst for highly efficient nitrogen reduction reaction (NRR). The synthesized ZrB2 nanocubes exhibited a highly attractive NRR performance with an NH3 yield of 37.7 µg h-1 mg-1 and a Faradaic efficiency 18.2% at -0.3 V (RHE). Theoretical calculations unraveled that active Zr centers enabled the effective activation of the N2 molecule via a unique tetranuclear side-on mode and concurrently impeded hydrogen evolution by restricting H+ adsorption.

14.
ACS Appl Mater Interfaces ; 12(33): 37258-37264, 2020 Aug 19.
Artigo em Inglês | MEDLINE | ID: mdl-32814395

RESUMO

Electrochemical nitrogen fixation offers a promising route for sustainable NH3 production, while the rational design of effective and durable electrocatalysts is urgently required for an effective nitrogen reduction reaction (NRR) process. Herein, we explore lithium iron oxide (LiFeO2) as a potential NRR catalyst. The developed LiFeO2/reduced graphene oxide (rGO) delivered a combination of both a high NH3 yield (40.5 µg h-1 mg-1) and high Faradaic efficiency (16.4%), exceeding those of nearly all the previously reported Li- and Fe-based catalysts. Theoretical computations showed that Fe and Li atoms on the LiFeO2 (111) facet synergistically activated N2 while Fe atoms served as the key active centers. Meanwhile, the undesired HER can be well impeded on both Fe and Li atoms to enable a high NRR selectivity.

15.
Drug Deliv ; 27(1): 909-916, 2020 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-32597334

RESUMO

Molybdenum disulfide (MoS2) has excellent photothermal conversion abilities, an ultra-high specific surface area, and has been extensively explored for use in biomedicine. However, the high toxicity associated with MoS2 has limited its biological applications for in vivo photothermal therapy and drug delivery systems. Herein, we have developed cationic hydroxyethyl cellulose (JR400) surface-modified MoS2 nanoparticles (NPs) that are responsive to near-infrared (NIR) laser irradiation as a transdermal drug delivery system (TDDS). Herein, we confirmed the preparation of hexagonal phase MoS2 with robust surface modification with JR400. The flower-like morphology of the NPs had an average diameter of 355 ± 69.3 nm limiting the absorption of the NPs through the stratum corneum. With the ability to efficiently load 90.4 ± 0.3% of the model drug atenolol (ATE), where 1 g of JR400-MoS2 NPs was able to load 3.6 g ATE, we assayed the controlled release capacity in vitro skin penetration studies. These JR400-MoS2 NPs showed further enhancement under NIR stimulation, with a 2.3-fold increase in ATE skin penetration. Furthermore, we verified in vivo that these JR400-MoS2 NPs do not cause skin irritation suggesting that they are promising new TDDS candidates for small molecule drugs.


Assuntos
Atenolol/administração & dosagem , Atenolol/farmacocinética , Dissulfetos/química , Sistemas de Liberação de Medicamentos/métodos , Molibdênio/química , Nanopartículas/química , Administração Cutânea , Animais , Celulose/análogos & derivados , Celulose/química , Química Farmacêutica/métodos , Relação Dose-Resposta a Droga , Liberação Controlada de Fármacos , Concentração de Íons de Hidrogênio , Masculino , Microscopia Eletrônica de Transmissão , Ratos , Ratos Wistar , Espectroscopia de Infravermelho com Transformada de Fourier , Difração de Raios X
16.
Exp Lung Res ; 46(6): 174-184, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32362153

RESUMO

Background: Previous studies have revealed the important role of alveolar macrophages (AMs) in the pathogenesis of acute respiratory distress syndrome (ARDS) and potential anti-inflammatory properties of lincRNA-p21. This study aims to study the association between lincRNA-p21 and active AMs to understand the molecular mechanisms of AMs-mediated inflammatory responses in ARDS.Methods: This study was mainly investigated in mice with the intratracheal instillation of lipopolysaccharide (LPS) or LPS-treated AMs. The expression of lincRNA-p21 and classical macrophage markers, IL-12ß and iNOS, was detected by quantitative RT-PCR, while NF-κB p65 translocation was measured by western blotting analysis. And, NF-κB activity was analyzed through luciferase report assays. Gain- and loss-of-function studies were also performed for further investigations.Results: Elevated lincRNA-p21 levels were observed in both LPS-induced ARDS mice and LPS-treated AMs, with upregulated expression of IL-12ß and iNOS, namely M1 activation, and p65 nuclear translocation. Further in vitro studies showed that LPS-induced M1 activation could be counteracted by both lincRNA-p21 inhibition and inhibited NF-κB activation. Moreover, both p65 nuclear translocation and NF-κB activity were promoted by lincRNA-p21 overexpression, while lincRNA-p21 inhibition showed a negative effect on LPS-induced p65 nuclear translocation and increase of NF-κB activity. Additionally, LPS-induced lung injuries could be attenuated by lincRNA-p21 inhibition in vivo.Conclusion: This study revealed elevated lincRNA-p21 levels in LPS-induced ARDS and investigated the potential role of lincRNA-p21 in LPS-induced pro-inflammatory response via NF-κB/p65 mediated pathways, suggesting the potential application of lincRNA-p21 for ADRS therapy.


Assuntos
Ativação de Macrófagos/genética , Macrófagos Alveolares/metabolismo , NF-kappa B/genética , RNA Longo não Codificante/genética , Síndrome do Desconforto Respiratório/genética , Quinases Ativadas por p21/genética , Animais , Regulação da Expressão Gênica/genética , Mediadores da Inflamação/metabolismo , Lipopolissacarídeos/farmacologia , Lesão Pulmonar/genética , Ativação de Macrófagos/efeitos dos fármacos , Macrófagos Alveolares/efeitos dos fármacos , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Transdução de Sinais/genética , Traqueia/efeitos dos fármacos , Traqueia/metabolismo , Fator de Transcrição RelA/genética
17.
Dalton Trans ; 49(22): 7467-7473, 2020 Jun 09.
Artigo em Inglês | MEDLINE | ID: mdl-32432591

RESUMO

Plasmon-mediated photocatalytic systems often suffer from weak absorption spectra overlap which limits energy transfer between plasmon metals and semiconductors. Herein, Au-Agx@CdS90 nanoparticles (NPs) with adjustable spectral overlap were prepared. Au-Ag hollow nanoparticles (HNPs) with tunable plasmon absorption peaks were used as the template and were coated with CdS to achieve stepwise spectral overlap for enhanced energy transfer. As the spectral overlap increased between Au-Ag HNPs and CdS, the H2 evolution rate increased and then decreased. Under visible-light irradiation, Au-Ag487@CdS90 nanoparticles (NPs) delivered an H2 evolution rate of 18.73 mmol h-1 g-1, which was 2.2 times higher than pure CdS. The plasmon resonance energy transfer from Au-Ag HNPs to the CdS semiconductor increased the generation of charge carriers in the semiconductor and enhanced the photocatalytic performance. By regulating the position of the plasmon absorption peaks of the noble metal nanoparticles, changing the spectral overlap between metal and semiconductor to enhance the PRET effect is beneficial to the design of new plasmon photocatalysts.

18.
Geriatr Gerontol Int ; 20(6): 629-636, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32227563

RESUMO

AIM: Lung cancer serves as one of the most common cancers in the world, and approximately 50% of non-small-cell lung cancer (NSCLC) patients are found to be aged >70 when diagnosed. In this study, we aimed to explore the effect of long non-coding RNAs colon cancer-associated transcript-1 (CCAT1) in NSCLC. METHODS: A total of 72 clinical samples from older NSCLC patients were collected for analysis. The relative mRNA level of CCAT1 was detected through real-time polymerase chain reaction. Overall survival of NSCLC patients was detected through Kaplan-Meier survival analysis. MTT assays were used to detect cell proliferation. Cell invasion was determined by transwell assay. Protein levels were detected through western blot. RESULTS: CCAT1 expression levels significantly increased in NSCLC tumor tissues and were associated with poor overall survival of NSCLC patients. CCAT1 promotes cell proliferation, cell invasion and epithelial-mesenchymal transition of NSCLC cell lines. CCAT1 binds with miR-152, and the effect of si-CCAT1 in NSCLC cell proliferation, cell invasion and epithelial-mesenchymal transition was partially reversed by anti-miR-152. CONCLUSIONS: Long non-coding RNA CCAT1 regulates tumor cell proliferation and invasion in NSCLC through suppressing miR-152. Geriatr Gerontol Int 2020; ••: ••-••.


Assuntos
Carcinoma Pulmonar de Células não Pequenas/metabolismo , Neoplasias Pulmonares/metabolismo , MicroRNAs/metabolismo , RNA Longo não Codificante/metabolismo , Idoso , Idoso de 80 Anos ou mais , Apoptose , Carcinoma Pulmonar de Células não Pequenas/genética , Carcinoma Pulmonar de Células não Pequenas/patologia , Proliferação de Células/genética , Transição Epitelial-Mesenquimal/genética , Feminino , Humanos , Neoplasias Pulmonares/genética , Neoplasias Pulmonares/patologia , Masculino , MicroRNAs/genética , Invasividade Neoplásica , RNA Longo não Codificante/genética
19.
ACS Appl Mater Interfaces ; 12(6): 7081-7090, 2020 Feb 12.
Artigo em Inglês | MEDLINE | ID: mdl-31965787

RESUMO

The electrochemical nitrogen reduction reaction (NRR) is a very efficient method for sustainable NH3 production, but it requires effective catalysts to expedite the NRR kinetics and inhibit the concomitant hydrogen evolution reaction (HER). Two-dimensional (2D)/2D interface engineering is an effective method to design powerful catalysts due to intimate face-to-face contact of two 2D materials that facilitates the strong interfacial electronic interactions. Herein, we explored a 2D/2D MoS2/C3N4 heterostructure as an active and stable NRR catalyst. MoS2/C3N4 exhibited a conspicuously improved NRR performance with an NH3 yield of 18.5 µg h-1 mg-1 and a high Faradaic efficiency (FE) of 17.8% at -0.3 V, far better than those of the individual MoS2 or C3N4 component. Density functional theory calculations revealed that the interfacial charge transport from C3N4 to MoS2 could enhance the NRR activity of MoS2/C3N4 by promoting the stabilization of the key intermediate *N2H on Mo edge sites of MoS2 and concurrently decreasing the reaction energy barrier. Meanwhile, MoS2/C3N4 rendered a more favorable *H adsorption free energy on S edge sites than on Mo edge sites of MoS2, thereby protecting the NRR-active Mo edge sites from the competing HER and leading to a high FE.

20.
Artigo em Inglês | MEDLINE | ID: mdl-31450650

RESUMO

Persistent organic pollutants (POPs) monitoring and management in typical semi-enclosed bays is a major global environmental issue. This study concentrated on a questionnaire survey and analysis of marine environmental management and monitoring departments at all levels in China, and proposed suggestions on the construction and improvement of POPs monitoring and management system. Results show that POPs are initially involved in China's current marine environmental monitoring system, and the monitoring strength and capability still need to be continuously improved, mainly in the recognition, funding input, relevant standards, monitoring, and evaluation technical regulations of marine environmental POPs monitoring. Therefore, in order to gradually improve the monitoring and management system of China's offshore marine environment POPs, this study suggests starting from four directions: (1) Building POPs monitoring system of a marine ecological environment, and strengthening POPs monitoring in different environmental media; (2) strengthening land-based POPs emission and the related human activities' intensity survey, and establishing a POPs information sharing database; (3) optimizing POPs monitoring technology in the marine environment, and improving POPs supervision and management technical support system; and (4) participating in regional and international marine environment POPs monitoring and evaluation projects, and strengthening the construction of talent teams.


Assuntos
Monitoramento Ambiental/métodos , Poluição da Água/análise , China , Água do Mar/análise , Inquéritos e Questionários
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