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1.
Arch Bronconeumol ; 2020 Feb 10.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-32057539

RESUMO

INTRODUCTION: The etiology of lung cancer is multifactorial. Exposure to tobacco smoke and the role played by the carcinogenic compounds that it contains would explain the common association between lung cancer and chronic obstructive pulmonary disease (COPD), a disease which is very much linked to tobacco use. In both diseases, sustained inflammation is caused by increased oxidative stress (for example, lipid peroxidation). This generates low molecular weight substances called volatile organic compounds (VOC) that are excreted during breathing. VOC metabolomics provides an indirect measure of oxidative stress. OBJECTIVE: The aim of this study was to establish the relative influence of COPD on the VOC profile in patients with non-small cell lung cancer (NSCLC), by first studying the possible variation of VOC associated with lung cancer histology. PATIENTS AND METHODS: Exhaled air was tested in 107 NSCLC patients, who were divided into 2groups: NSCLC with COPD and non-COPD with NSCLC. The exhaled air sample was obtained with the BIOVOC® sampler, and transferred to desorption tubes for later analysis by thermal desorption-gas chromatography-mass spectrometry. The VOC analysis showed lineal aldehydes and carboxylic acids. RESULTS AND CONCLUSIONS: No statistically significant differences were found in VOC associated with histology. NSCLC and COPD patients present a 1.7-fold (1.1-2.7) probability of detection of propionic acid (95% CI: 1.22- 6.2) than patients without COPD or NSCLC (P = 0.013).

2.
Artigo em Inglês | MEDLINE | ID: mdl-31963910

RESUMO

BACKGROUND: The Standardised Nordic Questionnaire (SNQ) is an instrument to analyse the musculoskeletal symptoms in an ergonomic or occupational health context. We aimed to cross-culturally adapt and evaluate the psychometric properties of the SNQ among Spanish musicians. METHODS: Cross-cultural adaptation and psychometric validation (reliability, validity, and feasibility) was performed. Reliability was analysed by test-retest reliability (Cohen's Kappa) and internal consistency (Kuder-Richardson). Content and face validity were measured by the Expert Committee and the opinion of participants. Construct validity (Mann-Whitney U test) was measured by comparing with questionnaires used to assess pain and disability in neck, shoulders, upper back, and low back regions. Feasibility was calculated with the average response time. RESULTS: A total of 312 Spanish musicians were included. The Spanish version of SNQ achieved good semantic, conceptual, idiomatic, and content equivalence. For most of the variables, test-retest reliability was good to very good (k = 0.60-0.81). The internal consistency showed good to acceptable (Kuder-Richardson 20 (KR20) = 0.737-0.873). Participants with versus without musculoskeletal problems in a related region showed significantly higher disability/pain, indicating a good construct validity. About the feasibility, the average response time of the questionnaire was 6 min (±2). CONCLUSIONS: The results show that the Spanish SNQ is reliable, valid, and feasible screening tool to assess musculoskeletal problems among musicians.

3.
Cient. dent. (Ed. impr.) ; 16(1): 7-15, ene.-abr. 2019. graf, tab
Artigo em Espanhol | IBECS | ID: ibc-183376

RESUMO

Introducción: El objetivo de este estudio consiste en evaluar la eficacia clínica y microbiológica de un colutorio a base de digluconato de clorhexidina (CHX) 0,05% y cloruro de cetilpiridinio (CPC) 0,05%, y otro colutorio sin propiedades antisépticas, empleados como coadyuvantes de los métodos de higiene oral. Material y métodos: Se llevó a cabo un estudio microbiológico que evaluó la capacidad de los colutorios para inhibir la formación y adherencia de un biofilm bacteriano de Streptococcus oralis mediante espectrofotometría, y un ensayo clínico, aleatorizado y doble ciego sobre una muestra de 48 pacientes, los cuales fueron asignados aleatoriamente a cada colutorio. A: CHX 0,05%, CPC 0,05% y lactato de cinc 0,14% y B: permethol 0.10% y provitamina B5 0.50%. El índice de placa (IP), el índice gingival modificado (IGM) y el índice de sangrado (IS) fueron evaluados con periodicidad mensual y trimestral. Resultados: El colutorio a base de CHX 0,05% y CPC 0,05% evidenció una elevada capacidad para inhibir la formación (P=0,013) y adherencia (P=0,001) del biofilm bacteriano Se observaron diferencias estadísticamente significativas en el IP inter-grupos a los tres meses de observación (P<0,001). También se observaron diferencias en el IGM al mes (P=0,034) y a los tres meses de observación (P<0,001); y en el IS al mes (P=0,004) y a los tres meses de observación (P=0,002). Conclusiones: El colutorio a base de CHX 0,05% y CPC 0,05% posee una capacidad superior para reducir la placa bacteriana y la gingivitis


Introduction: The aim of this study was to evaluate the clinical and microbiological efficacy of a mouthrinse containing 0.05% chlorhexidine digluconate (CHX) and 0.05% cetylpyridinium chloride (CPC), and another mouthrinse without antiseptic properties, used as adjuvants to oral hygiene methods. Material and methods: First a microbiological study using spectrophotometry was done to assess the ability of both mouthrinses to inhibit the formation and adhesion of an Streptococcus oralis biofilm. Then, a randomised, double-blind clinical trial was performed on a sample of 48 patients, who were randomly assigned to each mouthrinse. A: 0.05% CHX and 0.05% CPC, and B: 0.10% permethol and 0.50% provitamin B5. Plaque index (PI), modified gingival index (MGI) and bleeding index (BI) were assessed at one and three months. Results: The 0.05% CHX and 0.05% CPC mouthrinse showed a high capacity to inhibit the formation (P=0.013) and adhesion (P=0.001) of the bacterial biofilm. Statistically significant differences were observed in the inter-group PI after three months of monitoring (P<0.001). Differences were also observed in MGI after one month (P=0,034) and after three months of monitoring (P<0,001); and in BI after one month (P=0,004) and after three months of monitoring (P=0,002). Conclusions: The 0.05% CHX and 0.05% CPC mouthrinse has a good capacity to reduce bacterial plaque and gingivitis


Assuntos
Humanos , Masculino , Feminino , Adulto Jovem , Adulto , Pessoa de Meia-Idade , Antissépticos Bucais/administração & dosagem , Antissépticos Bucais/farmacologia , Clorexidina/administração & dosagem , Clorexidina/farmacologia , Cetilpiridínio/administração & dosagem , Cetilpiridínio/farmacologia , Streptococcus oralis/efeitos dos fármacos , Infecções Estreptocócicas/tratamento farmacológico , Placa Dentária/tratamento farmacológico , Placa Dentária/microbiologia , Estudos Prospectivos , Espectrofotometria , Método Duplo-Cego , Resultado do Tratamento
5.
Arch. bronconeumol. (Ed. impr.) ; 53(5): 251-256, mayo 2017. tab, graf
Artigo em Espanhol | IBECS | ID: ibc-162361

RESUMO

Introducción: Un factor de riesgo importante para el desarrollo de la enfermedad pulmonar obstructiva crónica (EPOC) es el humo del tabaco, que genera estrés oxidativo en las vías respiratorias, dando lugar a la producción de compuestos orgánicos volátiles (VOC). El objetivo del trabajo es su identificación en el aire exhalado y su posible utilidad como biomarcadores de la enfermedad. Método: Se analizó el aire exhalado de 100 voluntarios sanos, clasificados en 3 grupos (no fumadores, exfumadores y fumadores activos) y un grupo de 57 pacientes con EPOC. La muestra de aire exhalado se recogió mediante BioVOC® y se traspasó a tubos de desorción para su posterior análisis por cromatografía de gases y espectrometría de masas. Los VOC analizados fueron aldehídos lineales y ácidos carboxílicos. Resultados: Hexanal mostró diferencias estadísticamente significativas entre el grupo EPOC y los controles sanos (no fumadores y exfumadores), y nonanal entre el grupo control no fumador y el grupo EPOC. Conclusiones: Hexanal discrimina entre pacientes con EPOC y controles sanos no fumadores y exfumadores. Nonanal diferencia entre fumadores y exfumadores (con o sin EPOC) frente a controles no fumadores


Introduction: A major risk factor for chronic obstructive pulmonary disease (COPD) is tobacco smoke, which generates oxidative stress in airways, resulting in the production of volatile organic compounds (VOC). The purpose of this study was to identify VOCs in exhaled breath and to determine their possible use as disease biomarkers. Method: Exhaled breath from 100 healthy volunteers, divided into 3 groups (never smokers, former smokers and active smokers) and exhaled breath from 57 COPD patients were analyzed. Samples were collected using BioVOC® devices and transferred to universal desorption tubes. Compounds were analyzed by thermal desorption, gas chromatography and mass spectrometry. VOCs analyzed were linear aldehydesand carboxylic acids. Results: The COPD group and healthy controls (never smokers and former smokers) showed statistically significant differences in hexanal concentrations, and never smokers and the COPD group showed statistically significant differences in nonanal concentrations. Conclusions: Hexanal discriminates between COPD patients and healthy non-smoking controls. Nonanal discriminates between smokers and former smokers (with and without COPD) and never smokers


Assuntos
Humanos , Expiração , Eliminação Pulmonar , Doença Pulmonar Obstrutiva Crônica/fisiopatologia , Compostos Orgânicos Voláteis/análise , Fatores de Risco , Fumar/epidemiologia , Estudos de Casos e Controles
6.
J Chiropr Med ; 16(1): 31-40, 2017 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-28228695

RESUMO

OBJECTIVE: The aim of this study was to assess the methods to conduct a substantive clinical trial to evaluate the effects of accessory joint mobilization (AJM) vs neural mobilization (NM) techniques for shoulder motion restriction after breast cancer surgery. METHODS: This pilot study was a prospective randomized and double-blind clinical trial in which 18 women who underwent unilateral breast cancer surgery and axillary lymph node dissection participated. The study was conducted at the Women's Health Research Group at the Physical Therapy Department of Alcalá University, Madrid, Spain. The intervention was AJM vs NM, with a 6-month follow-up. Primary outcomes included recruitment, adherence to treatment and retention rates, assessment procedures, and implementation of the 2 manual therapy techniques. Secondary outcomes included range of motion, sensory disturbance, pain, and upper limb functionality. RESULTS: All participants accepted to be randomly assigned to study groups. One hundred percent retention was attained with all participants attending the 3-month and 6-month assessments. Adherence with treatment attendance was excellent. At 6-month follow-up, flexion range of motion had a mean change of 38.4° (±28.9) (P = .002) in the AJM group and a mean change of 36.8° (±21.8) (P = .002) in the NM group. Abduction range of motion had a median change of 52.4° (±43.6) (P = .004) in AJM group and a median change of 44° (±17.5) (P = .012). CONCLUSIONS: These preliminary results of the effects of AJM and NM techniques in breast cancer survivors indicate that a full clinical trial will be worthwhile. The research methods tested and the modifications proposed within this pilot study offer a suitable foundation to conduct a substantive clinical trial.

7.
Arch Bronconeumol ; 53(5): 251-256, 2017 May.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-27780574

RESUMO

INTRODUCTION: A major risk factor for chronic obstructive pulmonary disease (COPD) is tobacco smoke, which generates oxidative stress in airways, resulting in the production of volatile organic compounds (VOC). The purpose of this study was to identify VOCs in exhaled breath and to determine their possible use as disease biomarkers. METHOD: Exhaled breath from 100 healthy volunteers, divided into 3groups (never smokers, former smokers and active smokers) and exhaled breath from 57 COPD patients were analyzed. Samples were collected using BioVOC® devices and transferred to universal desorption tubes. Compounds were analyzed by thermal desorption, gas chromatography and mass spectrometry. VOCs analyzed were linear aldehydesand carboxylic acids. RESULTS: The COPD group and healthy controls (never smokers and former smokers) showed statistically significant differences in hexanal concentrations, and never smokers and the COPD group showed statistically significant differences in nonanal concentrations. CONCLUSIONS: Hexanal discriminates between COPD patients and healthy non-smoking controls. Nonanal discriminates between smokers and former smokers (with and without COPD) and never smokers.


Assuntos
Testes Respiratórios , Doença Pulmonar Obstrutiva Crônica/metabolismo , Compostos Orgânicos Voláteis/análise , Adulto , Idoso , Aldeídos/análise , Biomarcadores , Estudos de Casos e Controles , Ácidos Graxos/análise , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Propionatos/análise , Fumar/metabolismo , Abandono do Hábito de Fumar
8.
Pain Med ; 17(12): 2369-2377, 2016 12.
Artigo em Inglês | MEDLINE | ID: mdl-28025371

RESUMO

BACKGROUND: Chronic non-specific neck pain is a frequent complaint. It is a recognized medical and socioeconomic problem and a frequent cause of job absenteeism. In recent years, case reports about myofascial pain syndrome (MPS) are emerging among patients suffering from pain. MPS is a regional pain syndrome characterized by myofascial trigger points (MTrP) in palpable taut bands of skeletal muscle that refer pain to a distance, and that can cause distant motor and autonomic effects. OBJECTIVE: To assess the prevalence of active and latent MTrPs in subjects suffering from chronic non-specific neck pain. DESIGN: A population-based cross-sectional descriptive study was carried out from January 2012 to December 2014. SETTING: Three primary healthcare centers in Alcalá de Henares, Madrid (Spain). SUBJECTS: Two hundred and twenty-four participants diagnosed by their family doctor with chronic non-specific neck pain. METHODS: Participants were examined by a physical therapist to determine the presence of MPS. Pain descriptions from the subjects and pain body diagrams guided the physical examination. The subjects were not given any information concerning MPS or other muscle pain syndromes. RESULTS: All participants presented with MPS. MTrPs of the trapezius muscles were the most prevalent, in 93.75% of the participants. The most prevalent active MTrPs were located right (82.1%) and left (79%) in the nearly-horizontal fibers of the upper trapezius muscle. Furthermore, active MTrPs in the levator scapulae, multifidi, and splenius cervicis muscles reached a prevalence of 82.14%, 77.68%, and 62.5%, respectively. CONCLUSIONS: MPS is a common source of pain in subjects presenting chronic non-specific neck pain.


Assuntos
Dor Crônica/etiologia , Síndromes da Dor Miofascial/complicações , Síndromes da Dor Miofascial/epidemiologia , Cervicalgia/etiologia , Adulto , Estudos Transversais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Prevalência
9.
J Man Manip Ther ; 24(4): 223-32, 2016 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-27582622

RESUMO

BACKGROUND: Neck pain is a frequent complaint in office workers. This pain can be caused by myofascial trigger points (MTrPs) in the trapezius muscle. This study aimed to determine the effectiveness of deep dry needling (DDN) of active MTrPs in the trapezius muscle. METHODS: A randomized, single blinded clinical trial was carried out at the Physical Therapy Department at Physiotherapy in Women's Health Research Group at Physical Therapy Department of University of Alcalá, in Alcalá de Henares, Madrid, Spain. Forty-four office workers with neck pain and active MTrPs in the trapezius muscle were randomly allocated to either the DDN or the control group (CG). The participants in the DDN group were treated with DDN of all MTrPs found in the trapezius muscle. They also received passive stretch of the trapezius muscle. The CG received the same passive stretch of the trapezius muscle only. The primary outcome measure was subjective pain intensity, measured using a visual analogue scale (VAS). Secondary outcomes were pressure pain threshold (PPT), cervical range of motion (CROM) and muscle strength. Data were collected at baseline, after interventions and 15 days after the last treatment. RESULTS: Differences were found between the DDN group and the CG for the VAS (P < 0.001), PPT (P < 0.001), range of motion (AROM) (P < 0.05) and strength (P < 0.05) after intervention and at the 15-day follow-up. DISCUSSION: Deep dry needling and passive stretch seems to be more effective than passive stretch only. The effects are maintained in the short term. The results support the use of DDN in the management of trapezius muscle myofascial pain syndrome in neck pain.

10.
Eur J Obstet Gynecol Reprod Biol ; 190: 20-5, 2015 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-25955564

RESUMO

OBJECTIVE: To evaluate the responsiveness of the Spanish versions of Pelvic Floor Distress Inventory and Pelvic Floor Impact Questionnaire Short Forms (PFDI-20 and PFIQ-7), in order to assess symptoms and quality of life in Spanish women with pelvic floor disorders. STUDY DESIGN: Prospective observational study to assess the responsiveness in 85 women with pelvic floor disorders. PFDI-20 and PFIQ-7 were completed before and after Physiotherapy intervention. The responsiveness was assessed with the p values using the Wilcoxon signed-rank test, the standardized response means of the change (SRM) and the effect size (ES). RESULTS: The Spanish PFDI-20 and PFIQ-7 and the subscales demonstrated small to good responsiveness. The responsiveness was higher for PFDI-20 than for PFIQ-7. The statistic for PFDI-20 was moderate to good (ES 0.68 and SRM 0.84; p<0.0001), and small to moderate for PFIQ-7 (ES 0.48 and SRM 0.57; p<0.0001). Regarding the subscales, the responsiveness was better for Pelvic Organ Prolapse Distress Inventory (POPDI) than Pelvic Organ Prolapse Impact Questionnaire (POPIQ) (ES 0.70 and SRM 0.78; ES 0.42 and SRM 0.47 respectively; p<0.0001). Moderate responsiveness was found for Urinary Distress Inventory (UDI) and Urinary Impact Questionnaire (UIQ) (ES 0.54 and SRM 0.67; ES 0.52 and SRM 0.61 respectively; p<0.0001). Colo-Rectal-Anal Distress Inventory (CRADI) and Colo-Rectal-Anal Impact Questionnaire (CRAIQ) showed poor responsiveness, small in both (ES 0.42, SRM 0.50 and p<0.0001; ES 0.34, SRM 0.39 respectively; p<0.001). All responsiveness was significant. CONCLUSIONS: PFDI-20 and PFIQ-7 Spanish versions showed good responsiveness to evaluate the symptoms and the quality of life in Spanish women with PFD undergoing Physiotherapy treatment.


Assuntos
Distúrbios do Assoalho Pélvico/complicações , Qualidade de Vida , Índice de Gravidade de Doença , Inquéritos e Questionários , Adulto , Incontinência Fecal/etiologia , Feminino , Humanos , Linguagem , Pessoa de Meia-Idade , Distúrbios do Assoalho Pélvico/psicologia , Distúrbios do Assoalho Pélvico/terapia , Prolapso de Órgão Pélvico/etiologia , Modalidades de Fisioterapia , Estudos Prospectivos , Psicometria , Espanha , Incontinência Urinária por Estresse/etiologia
11.
Health Qual Life Outcomes ; 13: 63, 2015 May 23.
Artigo em Inglês | MEDLINE | ID: mdl-26001890

RESUMO

BACKGROUND: The Oxford Shoulder Score (OSS) and the Shoulder Pain and Disability Index (SPADI) are patient-based outcome scores with valid psychometric properties which are widely used for shoulder interventions. OBJECTIVE: The purpose of the study is to adapt both questionnaires cross-culturally to Spanish, and to test their reliability, validity, responsiveness, and feasibility. DESIGN: Cultural adaptation and psychometric validation study. METHODS: Consecutive patients who had undergone breast cancer surgery referred to an outpatient clinic at the University of Alcalá de Henares, Spain. One hundred and twenty women who had undergone breast cancer surgery, with pain and shoulder dysfunction. Cross-cultural adaptation was performed according to the international guidelines. Reliability was analysed by test-retest reliability and internal consistency. Content and convergent construct validity were measured by the Expert Committee's and Spearman coefficient respectively. Responsiveness, feasibility, floor and ceiling effects were also tested. RESULTS: One hundred and twenty women aged 54.2 (±11) years took part in the study. The reliability was excellent; test-retest reliability was 0.974 (p < 0.001) for OSS, and 0.992 (p < 0.001) for SPADI; and Cronbach's alpha value was 0.947 for OSS, and 0.965 for SPADI. High construct validity was found between the OSS and SPADI questionnaires (r = -0.674). The effect size (ES) and standardized response mean (SRM) was moderate in OSS (ES = 0.50 and SRM = 0.70 (p < 0.001)), and moderate to good in SPADI (ES = 0.59 and SRM = 0.82 (p < 0.001)). LIMITATIONS: This study has some limitations, such as the group of participants is composed only of women following breast cancer treatment; the measurement took place in a single centre; and all the questionnaires administered were always provided to the participants in the same order. CONCLUSIONS: The OSS and SPADI Spanish versions are applicable, reliable, valid, and responsive to assess shoulder symptoms and quality of life in Spanish women with shoulder pain and disability after breast cancer treatment.


Assuntos
Neoplasias da Mama/cirurgia , Dor Pós-Operatória/diagnóstico , Dor de Ombro/diagnóstico , Inquéritos e Questionários , Adulto , Idoso , Instituições de Assistência Ambulatorial , Comparação Transcultural , Avaliação da Deficiência , Estudos de Viabilidade , Feminino , Humanos , Pessoa de Meia-Idade , Medição da Dor , Dor Pós-Operatória/etiologia , Psicometria , Qualidade de Vida , Reprodutibilidade dos Testes , Sensibilidade e Especificidade , Dor de Ombro/etiologia , Espanha
12.
Mil Med ; 179(1): 71-5, 2014 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-24402988

RESUMO

Since 1987, the Spanish Armed Forces have deployed their troops in a multitude of conflicts and natural disasters worldwide. The Spanish Military Medical Corps has the ability to deploy Role 1, Role 2, and one Role 3 medical treatment facilities. It also has a Role 4 in operation, the "Gómez Ulla" Central Hospital of Defense, in Madrid. The aim of this study is to describe the type of Spanish casualties evacuated from different areas of operation to the Role 4 from 2008 to 2013. A retrospective, cross-sectional study was performed on a sample of 232 patients. Among these, 211 (91%) were noncombat casualties: 126 because of illness, 53 because of an accident, and 32 because of sports injuries. The remaining 21 (9%) were combat casualties: 11 from improvised explosive devices and 10 from gunfire. Afghanistan, followed by Lebanon, is the operational area where most evacuees originate. The authors consider it essential that the Spanish Armed Forces rely on a Role 4 medical treatment facility as part of their medical support to international operations.


Assuntos
Hospitais Militares , Militares , Transferência de Pacientes , Ferimentos e Lesões/terapia , Acidentes , Adulto , Estudos Transversais , Gerenciamento Clínico , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Espanha
13.
Arch. bronconeumol. (Ed. impr.) ; 49(11): 457-461, nov. 2013. tab, graf
Artigo em Espanhol | IBECS | ID: ibc-129134

RESUMO

Introducción: El humo del tabaco es una fuente de radicales libres y especies reactivas de oxígeno y de nitrógeno, principales causantes de estrés oxidativo. El análisis de compuestos orgánicos volátiles (VOC) en aire exhalado es un método indirecto de medir el nivel de estrés oxidativo que se produce en las vías aéreas. El objetivo de este trabajo es conocer la influencia del tabaco en la producción de VOC en una población clínicamente sana. Métodos: Se analizó el aire exhalado de 89 voluntarios sanos, clasificados en 3 grupos: no fumadores, exfumadores y fumadores activos. La muestra de aire exhalado se recogió mediante Bio-VOC®, y se traspasó a tubos de desorción. La técnica analítica utilizada fue: desorción térmica, cromatografía de gases y espectrometría de masas. Los VOC analizados fueron hexanal, heptanal, octanal, nonanal, ácido propanoico y ácido nonanoico, cuya identificación se realizó mediante su tiempo de retención y espectro de masas referenciado en la biblioteca NIST 08, confirmándolo mediante el uso de estándares cromatográficos. Resultados: La mayoría de los VOC analizados se encuentran a concentraciones muy bajas. Únicamente el nonanal muestra diferencia estadísticamente significativa entre los grupos de estudio, depende exclusivamente del hábito de fumar, y es independiente de la cantidad de tabaco consumido, edad y género. Conclusiones: El hallazgo de nonanal se asocia al consumo de tabaco, actual o previo. Al ser un producto secundario de la destrucción de la membrana celular, su hallazgo probablemente muestra daño celular en personas fumadoras y permanece una vez cesado el hábito (AU)


Introduction: Tobacco smoke is a source of free radicals and reactive oxygen and nitrogen species, which are the main causes of oxidative stress. The analysis of volatile organic compounds (VOC) in exhaled breath is an indirect method of measuring the level of oxidative stress that occurs in the airways caused by tobacco consumption. The aim of this study was to determine whether smoking influences the production of VOC, in a clinically healthy population. Methods: Exhaled breath from 89 healthy volunteers, divided into three groups (non-smokers, ex-smokers and smokers), was analyzed. Samples were collected using Bio-VOC® devices and transferred to universal desorption tubes. Chemical compounds were analyzed by thermal desorption, gas chromatography and mass spectrometry. We analyzed hexanal, heptanal, octanal, nonanal, nonanoic acid and propanoic acid, and all were identified by retention time and mass spectra referenced in the NIST 08 mass spectral library; confirmation was carried out using reference standards of the pure chemical compound. Results: These VOC were found in very low concentrations. Only nonanal showed significant quantitative and qualitative statistical differences among the study groups. Nonanal concentration is dependent on smoking, but is independent of the amount of tobacco consumed, age and gender. Conclusions: Nonanal in exhaled breath is associated with tobacco consumption, current or previous. Nonanal is a sub-product of the destruction of the cell membrane, and its finding may be indicative of cell damage in smokers. This result appears in many farmers who smoke (AU)


Assuntos
Humanos , Fumar/efeitos adversos , Compostos Orgânicos Voláteis/isolamento & purificação , Estresse Oxidativo/fisiologia , Poluentes Orgânicos , Estudos de Casos e Controles
14.
Eur J Obstet Gynecol Reprod Biol ; 170(1): 281-5, 2013 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-23891390

RESUMO

OBJECTIVE: To develop a linguistically adapted and psychometrically validated Spanish version of the Pelvic Floor Distress Inventory and Pelvic Floor Impact Questionnaire Short Forms (PFDI-20 and PFIQ-7) to assess symptoms and quality of life in Spanish women with pelvic floor disorders. STUDY DESIGN: Cross-cultural linguistic adaptation was performed following the translation-backtranslation method in 30 native Spanish-speaking women with pelvic floor disorders to obtain PFDI-20 and PFIQ-7 Spanish versions. The psychometric properties were evaluated in 114 women with pelvic floor disorders. We calculated the reliability with the intraclass correlation coefficient and Cronbach's alpha coefficient, the validity with Spearman coefficient, the feasibility with the response rate and the filling time, and the ceiling and floor effects. RESULTS: Spanish versions of the PFDI-20 and PFIQ-7 achieved good semantic, conceptual, idiomatic and content equivalence. Concerning the psychometric validation, internal consistency was high with Cronbach's alpha coefficient of 0.837 (p<0.001) for PFDI-20 and 0.967 (p<0.001) for PFIQ-7. The test-retest reliability was 0.644 (p<0.001) for the PFDI-20 and 0.786 (p<0.001) for the PFIQ-7. Good construct validity was found with questionnaires: SF-12, EPIQ and ICIQ-SF. The average administration time was 10.1 (5.8)min for the PFDI-20, and 7.5 (4.7)min for the PFIQ-7. A ceiling effect was detected in the PFIQ-7 (25.4%). CONCLUSIONS: The PFDI-20 and PFIQ-7 Spanish versions showed semantic, conceptual, idiomatic and content equivalence with the original versions. Both instruments are reliable, valid and feasible to evaluate symptoms and quality of life in Spanish women with pelvic floor disorders.


Assuntos
Distúrbios do Assoalho Pélvico/diagnóstico , Inquéritos e Questionários , Idoso , Características Culturais , Feminino , Humanos , Linguística , Pessoa de Meia-Idade , Psicometria
15.
Arch Bronconeumol ; 49(11): 457-61, 2013 Nov.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-23791244

RESUMO

INTRODUCTION: Tobacco smoke is a source of free radicals and reactive oxygen and nitrogen species, which are the main causes of oxidative stress. The analysis of volatile organic compounds (VOC) in exhaled breath is an indirect method of measuring the level of oxidative stress that occurs in the airways caused by tobacco consumption. The aim of this study was to determine whether smoking influences the production of VOC, in a clinically healthy population. METHODS: Exhaled breath from 89 healthy volunteers, divided into three groups (non-smokers, ex-smokers and smokers) was analysed. Samples were collected using Bio-VOC® devices and transferred to universal desorption tubes. Chemical compounds were analysed by thermal desorption, gas chromatography and mass spectrometry. We analysed hexanal, heptanal, octanal, nonanal, nonanoic acid and propanoic acid, all identified by retention time and mass spectra referenced in the NIST 08 mass spectral library; confirmation was carried out using reference standards of the pure chemical compound. RESULTS: These VOC were found in very low concentrations. Only nonanal showed significant quantitative and qualitative statistical differences among the study groups. Nonanal concentration is dependent on smoking, but is independent of the amount of tobacco consumed, age and gender. CONCLUSIONS: Nonanal in exhaled breath is associated with tobacco consumption, current or previous. Nonanal is a sub-product of the destruction of the cell membrane, and its finding may be indicative of cell damage in smokers. This result appears in many farmers who smoke.


Assuntos
Testes Respiratórios , Fumaça/análise , Fumar , Tabaco/química , Compostos Orgânicos Voláteis/análise , Adulto , Aldeídos/análise , Estudos de Casos e Controles , Membrana Celular/química , Feminino , Cromatografia Gasosa-Espectrometria de Massas , Humanos , Masculino , Pessoa de Meia-Idade , Estresse Oxidativo , Abandono do Hábito de Fumar
16.
Mil Med ; 177(3): 326-32, 2012 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-22479922

RESUMO

OBJECTIVE: To provide an analysis of casualties treated during medical evacuation (MEDEVAC) or/and at the Spanish Role 2 in Herat, Afghanistan, including type of weapon, injuries, and effects of protective measures. METHOD: A retrospective analysis was carried out concerning patients who had suffered injuries from either gunshot or explosive devices treated during MEDEVAC or/and at this facility during the period 2005-2008. RESULTS: The total number of cases analyzed was 256. The majority of the casualties were produced by explosive devices (71%). The anatomical regions most affected were the lower limbs (48%). There was a higher New Injury Severity Score in casualties wounded by gunshot (14 +/- 1) than in those wounded by explosive devices (8.5 +/- 1.5) (p < 0.001). Surgical procedures for injuries caused by gunshots were 1.7 times more likely than for those due to explosive devices (95% confidence interval: 1.4 to 2.1). Protective devices were used only by 25% of casualties. CONCLUSIONS: The injury score indices of firearm casualties were higher than the explosive device casualties' injury score indices. The possible reasons for this finding are discussed.


Assuntos
Campanha Afegã de 2001- , Traumatismos por Explosões/epidemiologia , Militares , Ferimentos por Arma de Fogo/epidemiologia , Adulto , Traumatismos Craniocerebrais/epidemiologia , Feminino , Humanos , Escala de Gravidade do Ferimento , Traumatismos da Perna/epidemiologia , Masculino , Equipamentos de Proteção , Estudos Retrospectivos , Espanha , Ferimentos por Arma de Fogo/terapia , Adulto Jovem
17.
Med. segur. trab ; 58(226): 49-58, ene.-mar. 2012. ilus, tab, graf
Artigo em Espanhol | IBECS | ID: ibc-103146

RESUMO

Introducción: Ácido úrico sérico y Síndrome Metabólico, son factores que se relacionan fuertemente con enfermedades cardiovasculares. Objetivo: conocer la prevalencia de Síndrome Metabólico así como la concentración de Ácido úrico sérico en una población aeronáutica y determinar qué posibles relaciones muestran unos niveles normales y/o patológicos de Ácido úrico con respecto a la presencia o ausencia de Síndrome Metabólico. Material y métodos: Población de 790 pilotos de líneas aéreas, todos varones. Se siguió el criterio del National Cholesterol Education Program para el diagnóstico de Síndrome Metabólico, pero modificado, utilizándose en lugar de circunferencia cintura el índice de masa corporal. Resultados: El 25,4% de los pilotos presentaron valores elevados de Ácido Úrico. El 19,9% de los pilotos presentó Síndrome Metabólico. El riesgo de presentar Síndrome Metabólico por tener el Ácido úrico elevado frente al riesgo que presentaron los que tienen el Ácido úrico normal (razón de prevalencias) fue de 2,6 con un intervalo de confianza al 95% entre 2 y 3,4 y con una significación de p<0,001. Existe una asociación lineal positiva entre el aumento de la concentración de Ácido úrico y el número de factores diagnósticos positivos de Síndrome Metabólico (p<0,001). Conclusiones: Nuestros resultados sugieren que la hiperuricemia puede ser una complicación relacionada son el propio Síndrome Metabólico; la obesidad abdominal puede condicionar un aumento en la concentración de Ácido úrico. Se hace preciso aumentar los estudios sobre poblaciones aeronáuticas respecto a estos factores metabólicos con objeto de aumentar la seguridad en vuelo (AU)


Fundamentals: Uric acid and metabolic syndrome are strongly related to cardiovascular disease. Objective: To assess the prevalence of metabolic syndrome as well as the levels of uric acid among aircrew members and to determine the relationship between the levels of uric acid and the prevalence of metabolic syndrome. Methods: We studied a population of 790 male airline pilots. We used the definition of metabolic syndrome of the National Cholesterol Education Program Adult Treatment Panel III, but modified by replacing waist circumference for the measurement of body mass index. Results: 25.4% of the pilots presented elevated level of uric acid. 19.9% of pilots presented metabolic syndrome. The risk to present metabolic syndrome in pilots with uric acid elevated in relation to those pilots with normal uric acid was 2.6 higher with a confidence interval of 95% between 2 and 3,4 with a significance of p<0.001. There is a positive linear association between the increased concentration of uric acid and the number of metabolic syndrome diagnostic criteria (p<0,001). Conclusions: Our results suggest that hyperuricemia can be a complication related to the metabolic syndrome. The abdominal obesity may condition an increased concentration of serum uric acid. It is necessary to increase the number of studies on aircrew members in relation to the above mentioned metabolic factors in order to increase the flight safety (AU)


Assuntos
Humanos , Masculino , Síndrome Metabólica/epidemiologia , Ácido Úrico/sangue , Hiperuricemia/epidemiologia , Aviação , Índice de Massa Corporal , Fatores de Risco , Obesidade Abdominal/epidemiologia
18.
Med. aeroesp. ambient ; 4(6): 263-267, jun. 2006. ilus, tab
Artigo em Espanhol | IBECS | ID: ibc-052019

RESUMO

En una población de 762 pilotos de transporte pertenecientes a distintas líneas aéreas españolas se determinó glucemia plasmática basal en ayunas con motivo de su examen físico periódico. De ellos, 604 pilotos (79,3%) presentaron nivel de glucemia basal normal (= 100 y 126 mg/dl) y 8 pilotos (1%) fueron diagnosticados de diabetes mellitus (glucosa >= 126mg/dl), de acuerdo con los últimos criterios de la Asociación Americana de Diabetes (2003). La prevalencia de glucemia basal alterada, condición que predispone al desarrollo de diabetes y constituye un factor de riesgo cardiovascular aumenta con la edad y así de 9,5% en menores de 30 años, pasa a 12,9% en el grupo de 30 a 40 años, a 21,7% en el grupo de 40 a 50 años y a 32,4% en el grupo de más de 50 años. La prevalencia de diabetes mellitus aumenta con la edad y así mientras en menores de 30 años no se detectó ningún caso, en los pilotos de más de 50 años se detectaron 50 casos


In a sample of 762 transport pilots belonging to different Spanish airlines, the fasting plasma glucose was measured at the time of their periodical physical examination. According to last criteria established by the American Diabetes association (2003) 604 pilots (79,3%) presented a normal fasting plasma glucose (=100 y = 126mg/dl). The prevalence of impaired fasting glucose, condition that predisposes to diabetes and cardiovascular disease, increases with aging. In this regard, the prevalence of 9,55 inpilots under 30 years of age, increased to 12,9% in the group with 30 to 40 years of age, to 21,7% in the group of 40 to 50 years and up to 32,4% in pilots with 50 years and older. the prevalence of diabetes als rises with age and while in pilots under 30 years of age no single case of diabetes was detected, 5 cases were found in the group of 50 years and older, accounting for 2,9%


Assuntos
Masculino , Adulto , Pessoa de Meia-Idade , Humanos , Hiperglicemia/epidemiologia , Diabetes Mellitus Tipo 2/epidemiologia , Aeronaves , Medicina Aeroespacial
19.
Med. mil ; 58(1): 38-41, ene.-mar. 2002. tab
Artigo em Espanhol | IBECS | ID: ibc-37471

RESUMO

El artículo da noticia de la existencia del "Sistema coordinado de intercambio rápido de información en materia de seguridad alimentaria" de la Unión Europea y la Asociación Europea de Libre Comercio y de su funcionamiento entre los años 1995 y 1999 (AU)


Assuntos
Humanos , Socorro Alimentar , Abastecimento de Alimentos/normas , Contaminação de Alimentos , Sistemas de Informação/organização & administração , Sistemas de Alerta Rápido , Fatores de Risco , União Europeia
20.
Med. mil ; 56(2): 68-76, abr.-jun. 2000. ilus, tab, graf
Artigo em Espanhol | IBECS | ID: ibc-37454

RESUMO

Introducción y objetivos: Wright JE et al., en 1964 y Ni Y et al., en 1994, demostraron en ratas, mediante microcolangiografía con micropaque, la repermeabilización del conducto hepático biliar común (CHC) después de haber practicado su ligadura, hecho señalado por vez primera por Cameron GR et al., en 1932 y 1960. La investigación experimental -estudio clínico- está basada en una estrategia prospectiva transversal tras producir obstrucción quirúrgica del conducto hepático común. Los objetivos de este trabajo son: el seguimiento clínico y estudio de la alteración de los parámetros bioquímicos de la función hepática, bilirrubina total (BT), alanin aminotranferasa (ALT) y fosfatasa alcalina (FA), tras la doble ligadura y sección del CHC en el cerdo minipig Gottingen; así como los estudios de ecografia, microcolangiografía y anatomopatológico. Material y método: Se emplearon cerdos minipig de raza Gottingen, agrupados en dos series: serie 1, experimental, de 8 animales, a los que se les practicó doble ligadura y sección del CHC, serie H, sham operation, de 8 animales a los que se les realizó laparotomía y manipulación del hígado y su hilio. En ambas series se hizo seguimiento clinico, serológico y ecográfico; y tras un periodo de observación de 120 días se sacrificaron, para estudio microcolangiográfico con micropaque e histológico con microscopía óptica. Resultados y conclusiones: Como consecuencia de la ligadura quirúrgica del CHC, se observó ictericia durante los primeros 30 días y, dilatación de la vía biliar extrahepática e intrahepática a lo largo de todo el período de observación. Durante la fase aguda, se produjo aumento de ALT, BT y FA. Durante la fase crónica, hacia los 60 días, se produjo normalización de los niveles de la BT, mientras que la ALT presentó valores en torno al límite superior de la normalidad. La microcolangiografía puso de relieve la ausencia de regeneración de la vía biliar extrahepática, por lo que no se restableció el flujo biliar hacia duodeno. Microscópicamente, se objetivó proliferación ductal y gemación a partir de conductos de mediano y pequeño calibre, y número moderado de nódulos hepatocitarios de regeneración, de aparición tardía. Se considera que el modelo experimental en cerdos se acerca más a las condiciones anatómicas y fisiopatológicas del ser humano, y podría resultar más idóneo para este tipo de investigaciones, que otros animales de experimentación (AU)


Assuntos
Animais , Ligadura , Modelos Animais de Doenças , Colestase/fisiopatologia , Ducto Colédoco/fisiopatologia , Suínos , Bilirrubina , Alanina Transaminase , Fosfatase Alcalina , Colecistectomia/efeitos adversos , Regeneração Hepática/fisiologia , Testes de Função Hepática/métodos
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