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8.
Iran J Basic Med Sci ; 19(5): 483-9, 2016 May.
Artigo em Inglês | MEDLINE | ID: mdl-27403254

RESUMO

OBJECTIVES: In the present study, our aim was to investigate the possible protective effects of epigallocatechin gallate (EGCG) on lipopolysaccharide (LPS)-induced hepatotoxicity by using Hep3B human hepatoma cells. Specifically, the study examines the role of some proinflammatory markers and oxidative damage as possible mechanisms of LPS-associated cytotoxicity. Consequently, the hepatocellular carcinoma cell line Hep3B was chosen as a model for investigation of LPS toxicity and the effect of EGCG on LPS-exposed cells. MATERIALS AND METHODS: The Hep3B human hepatoma cells were used for this study. The cytotoxic effects of chemicals (EGCG and LPS), AST and ALT levels, SOD and CAT activities, GSH-Px level and TNF-alpha and IL-6 levels were detected by using different biochemical and molecular methods. LPS and EGCG were applied to cells at various times and doses. RESULTS: The highest treatment dose of EGCG (400 µM) led to a dramatic decrease in SOD level and increase in CAT and GSH levels. Additionally, the highest dose of EGCG also led to a dramatic increase in TNF-alpha and IL-6 levels. On the other hand, effective doses of EGCG (200 and 100 µM) normalized all related parameters levels. CONCLUSION: LPS caused hepatotoxicity, but interestingly, a high dose of EGCG was found to be a cytotoxic agent in this study. However, other two doses of EGCG led to a decrease in both inflammatory cytokine levels and antioxidant enzyme levels. Further studies should examine the effect of EGCG on secondary cellular signaling pathways.

9.
Med Princ Pract ; 25(5): 494-6, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27304675

RESUMO

OBJECTIVE: Our aim was to report the importance of an awareness of renal artery variations if surgical procedures are indicated in this region. Presentation and Intervention: A 41-year-old female patient was admitted to our hospital for preoperative staging of the rectum carcinoma. A computed tomography (CT) scan clearly revealed the presence of normally positioned small right and left renal arteries, and a large aberrant renal artery originating from the distal abdominal aorta in a case with a horseshoe kidney (HSK). A multidetector CT angiography was performed using a 256-detector row CT scanner to obtain an image of vascular structures and associated pathologies. CONCLUSION: In this patient with HSK, the left renal vein compression was unusual and the CT examination provided a good delineation of vascular and urinary tract anomalies.


Assuntos
Rim Fundido/diagnóstico por imagem , Rim Fundido/patologia , Veias Renais/diagnóstico por imagem , Veias Renais/patologia , Adulto , Feminino , Humanos , Tomografia Computadorizada Multidetectores
10.
Braz. j. microbiol ; 47(1): 167-171, Jan.-Mar. 2016. tab, graf
Artigo em Inglês | LILACS | ID: lil-775116

RESUMO

Abstract Helicobacter pylori infection is usually acquired in early childhood and it can persist throughout life without antibiotic treatment. This study aimed to compare the accuracy of the noninvasive H. pylori Stool Antigen Test-applied on the stool samples with the invasive gold standart Rapid Urease Test-applied on the gastric biopy samples of patients with upper gastrointestinal complaints. After endoscopy, biopsy and stool specimens were taken in 122 patients. The infection was detected with rapid urease test which is accepted as gold standart test. Rapid, one-step H. pylori card test was applied to all patients stool specimens. In this study 106 of the 122 patients (86.8%) were positive for H. pylori infection, while 16 of the 122 patients (13.2%) were negative. H. pylori card test was negative in 13 of the 16 patients and was positive in 98 of the 106. The sensitivity, specifity, positive and negative predictive values were 92.45%, 81.25%, 97.02%, and 61.90%, respectively. H. pylori card test is rapid, easy, noninvasive and inexpensive methods for detection H. pylori infection. This test showed high sensitivity and specificity. Additionally, it may be a good alternative to invasive tests for the detection of H. pylori infections especially in children.


Assuntos
Humanos , Antígenos de Bactérias/análise , Fezes/microbiologia , Gastroenteropatias/diagnóstico , Helicobacter pylori/isolamento & purificação , Fezes/química , Valor Preditivo dos Testes , Sensibilidade e Especificidade
11.
Spine J ; 16(9): e571, 2016 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-26854740
12.
Braz J Microbiol ; 47(1): 167-71, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-26887240

RESUMO

Helicobacter pylori infection is usually acquired in early childhood and it can persist throughout life without antibiotic treatment. This study aimed to compare the accuracy of the noninvasive H. pylori Stool Antigen Test-applied on the stool samples with the invasive gold standart Rapid Urease Test-applied on the gastric biopy samples of patients with upper gastrointestinal complaints. After endoscopy, biopsy and stool specimens were taken in 122 patients. The infection was detected with rapid urease test which is accepted as gold standart test. Rapid, one-step H. pylori card test was applied to all patients stool specimens. In this study 106 of the 122 patients (86.8%) were positive for H. pylori infection, while 16 of the 122 patients (13.2%) were negative. H. pylori card test was negative in 13 of the 16 patients and was positive in 98 of the 106. The sensitivity, specifity, positive and negative predictive values were 92.45%, 81.25%, 97.02%, and 61.90%, respectively. H. pylori card test is rapid, easy, noninvasive and inexpensive methods for detection H. pylori infection. This test showed high sensitivity and specificity. Additionally, it may be a good alternative to invasive tests for the detection of H. pylori infections especially in children.


Assuntos
Antígenos de Bactérias/análise , Fezes/microbiologia , Gastroenteropatias/diagnóstico , Helicobacter pylori/isolamento & purificação , Fezes/química , Humanos , Valor Preditivo dos Testes , Sensibilidade e Especificidade
15.
Int Surg ; 100(3): 514-7, 2015 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-25785337

RESUMO

Cystic and solid tumors of the ovary are rare during the newborn period and infancy. We present the case of a term female infant born to a mother of 28 years of age and found to have a cystic abdominal mass through prenatal sonographic evaluation in the third trimester. The complex cyst was also demonstrated by postnatal abdominal ultrasonography. Laparotomy revealed a large cystic mass with a torsed right ovary. Pathologic examination of cyst revealed hemorrhagic necrosis with ovarian torsion.


Assuntos
Cistos Ovarianos/congênito , Cistos Ovarianos/diagnóstico por imagem , Anormalidade Torcional/congênito , Anormalidade Torcional/diagnóstico por imagem , Ultrassonografia Pré-Natal , Adulto , Feminino , Humanos , Recém-Nascido , Gravidez
16.
Jpn J Radiol ; 33(1): 33-8, 2015 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-25466769

RESUMO

OBJECTIVES: In this paper we describe sonoelastography findings for idiopathic granulomatous mastitis (IGM), the clinical and radiological features of which often mimic those of breast carcinoma. MATERIALS AND METHODS: In this retrospective study, sonoelastography findings for patients with pathologically proved IGM were studied. Twenty-seven patients with pathologically proved IGM were enrolled in the study. All were female, and the mean age was 37.81 years (standard deviation 7.10 years; range 24 to 56 years). Elasticity scores (ES), strain ratios (SR), and elastic diameters (ED) were evaluated for the lesions. RESULTS: Ten lesions (37.0 %) were diffuse, six (22.2 %) were tubular, six (22.2 %) were a mass, and five (18.5 %) were cystic in appearance on ultrasonography. On sonoelastography, mean ES ± standard deviation was 1.66 ± 0.55 (between 1.00 and 3.00); mean SR ± standard deviation was 1.10 ± 0.79 (between 0.29 and 4.00). ED was no different between grey-scale and sonoelastogram images. CONCLUSIONS: The features of idiopathic granulomatous mastitis suggest it is benign in nature.


Assuntos
Técnicas de Imagem por Elasticidade , Mastite Granulomatosa/diagnóstico , Adulto , Elasticidade , Feminino , Humanos , Pessoa de Meia-Idade , Estudos Retrospectivos
18.
Ulus Cerrahi Derg ; 30(4): 192-6, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-25931927

RESUMO

OBJECTIVE: Many surgeons face difficulties during single-incision laparoscopic cholecystectomy (SILC) surgery and are forced to use an additional port. We compared the results of a technique that we developed with SILC. MATERIAL AND METHODS: Fifty-four patients who were diagnosed with chronic cholelithiasis were prospectively randomized and divided into two groups. An additional 5-mm port (MCAP: with an additional port using a multi-channel device through the umbilicus) was placed in the subxiphoid area instead of a transabdominal suspension suture in one group of patients. The other group was operated on with the SILC technique. The demographic and surgical data of the patients were compared. RESULTS: The MCAP technique shortened the surgery duration by more than half (MCAP: 35.0±12.3, SILC: 79.1±27.7 min) (p<0.05). No difference was found between the two methods in terms of estimated blood loss, length of hospitalization, postoperative day 1 and 7 visual analog scale scores, need for analgesia in the postoperative period, and rate of changing to another technique due to inadequacy of the surgical technique. CONCLUSION: MCAP is as safe as SILC for cholecystectomy and is easier for the surgeon to perform.

19.
Am J Surg ; 194(3): 313-6, 2007 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-17693274

RESUMO

BACKGROUND: A serious complication of cystic echinococcus (CE) is the rupture of the cysts. Free intra-abdominal rupture occurs in approximately 3.2% of all cases. Posttraumatic rupture of liver CE is very rare. METHODS: The objective of the current study was to evaluate the clinical and radiographic findings and surgical treatment of this complication. RESULTS: Twenty patients with posttraumatic ruptured liver CE were treated. The incidence rate of hydatid rupture was 3.06%. The common presenting symptom was abdominal pain. All patients were operated on under emergency conditions. There were 26 cysts in 20 patients, and all of the cysts were treated surgically. CONCLUSION: Hydatid cyst rupture must be kept in mind in the management of trauma patients with cystic mass in the liver in particular and free intra-abdominal fluid, especially in the endemic area. We preferred conservative (unroofing associated with various procedures for the management of the residual cavity) rather than radical procedures such as hepatic resection or pericystectomy for the surgical treatment.


Assuntos
Equinococose Hepática/complicações , Adolescente , Adulto , Idoso , Equinococose Hepática/diagnóstico , Equinococose Hepática/cirurgia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Peritônio , Ruptura
20.
ANZ J Surg ; 77(6): 455-9, 2007 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-17501886

RESUMO

BACKGROUND: Hydatid cyst (HC) continues to be endemic in the Mediterranean countries, such as Turkey. Living in a rural area is an important risk factor for the disease. HC is most commonly seen in the liver and lungs, but retroperitoneal hydatid cyst is very rare. The objective of this study was to evaluate the clinical and radiographic findings and surgical treatment of this unusual lesion. METHODS: Between 1979 and 2004, 14 cases with primary retroperitoneal hydatid cyst were treated surgically at our clinic. RESULTS: Symptoms included flank pain in eight (57.1%) and palpable mass in six patients (42.8%). The cyst was located in the right retroperitoneum in seven patients (50%), left retroperitoneum in five patients (35.7%), retrovesical region in one patient (7.1%) and paravesical region in one patient (7.1%). Surgical approaches were right paramedian extraperitoneal approach in four patients, left paramedian extraperitoneal approach in two patients and midline transperitoneal approach in eight patients. Total pericystectomy was chosen as the surgical procedure in all patients except in five (35.7%), who had partial cystectomy for cysts located near the vital structures. There were no complications and mortality postoperatively. CONCLUSION: A primary HC of the retroperitoneum is a distinct clinical entity that must be considered when caring for a patient with a retroperitoneal mass in endemic regions. It should be treated after the diagnosis is confirmed without any delay because of secondary spillages due to perforations and other possible complications.


Assuntos
Equinococose/diagnóstico , Equinococose/cirurgia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Espaço Retroperitoneal
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