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1.
Arch Cardiol Mex ; 89(4): 315-323, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31834307

RESUMO

Objective: To validate prospectively in multiple centers, the accuracy and clinical utility of the European System for Cardiac Operative Risk Evaluation (EuroSCORE II) to predict the operative mortality of cardiac surgery in Argentina. Methods: Between January 2012 and February 2018, 2,000 consecutive adult patients who underwent cardiac surgery in different centers in Argentina were prospectively included. The end-point was in-hospital all-cause mortality. Discrimination, calibration, precision and clinical utility of the EuroSCORE II were evaluated in the global cohort and in the different types of surgeries, based on ROC (Receiver Operating Characteristics) curves, Hosmer-Lemeshow goodness-of-fit test, observed/expected mortality ratio, Shannon index and decision curves analysis. Results: ROC area of the EuroSCORE II was between 0.73 and 0.80 for all types of surgery, being the lowest value for coronary surgery. The observed and expected mortality was 4.3% and 3.0%, respectively (p = 0.034). The decision curve analysis showed a positive net benefit for all thresholds below 0.24, considering all type of surgeries. Conclusion: The EuroSCORE II showed an adequate performance in terms of discrimination and calibration for all types of surgery, although somewhat inferior for coronary surgery. Though in general terms this model underestimated the risk in intermediate risk groups, its overall performance was acceptable. The EuroSCORE II could be considered an optional updated generic model of operative risk stratification to predict in-hospital mortality after cardiac surgery in our context.

2.
Pulm Med ; 2019: 4071762, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31687208

RESUMO

Background: The number of incidental findings of pulmonary nodules using imaging methods to diagnose other thoracic or extrathoracic conditions has increased, suggesting the need for in-depth radiological image analyses to identify nodule type and avoid unnecessary invasive procedures. Objectives: The present study evaluated solid indeterminate nodules with a radiological stability suggesting benignity (SINRSBs) through a texture analysis of computed tomography (CT) images. Methods: A total of 100 chest CT scans were evaluated, including 50 cases of SINRSBs and 50 cases of malignant nodules. SINRSB CT scans were performed using the same noncontrast enhanced CT protocol and equipment; the malignant nodule data were acquired from several databases. The kurtosis (KUR) and skewness (SKW) values of these tests were determined for the whole volume of each nodule, and the histograms were classified into two basic patterns: peaks or plateaus. Results: The mean (MEN) KUR values of the SINRSBs and malignant nodules were 3.37 ± 3.88 and 5.88 ± 5.11, respectively. The receiver operating characteristic (ROC) curve showed that the sensitivity and specificity for distinguishing SINRSBs from malignant nodules were 65% and 66% for KUR values >6, respectively, with an area under the curve (AUC) of 0.709 (p < 0.0001). The MEN SKW values of the SINRSBs and malignant nodules were 1.73 ± 0.94 and 2.07 ± 1.01, respectively. The ROC curve showed that the sensitivity and specificity for distinguishing malignant nodules from SINRSBs were 65% and 66% for SKW values >3.1, respectively, with an AUC of 0.709 (p < 0.0001). An analysis of the peak and plateau histograms revealed sensitivity, specificity, and accuracy values of 84%, 74%, and 79%, respectively. Conclusions: KUR, SKW, and histogram shape can help to noninvasively diagnose SINRSBs but should not be used alone or without considering clinical data.

3.
Rev. argent. cardiol ; 87(1): 16-20, feb. 2019. graf
Artigo em Espanhol | LILACS-Express | ID: biblio-1003244

RESUMO

RESUMEN Objetivos: Comparar pacientes con infarto agudo de miocardio con elevación del segmento ST (IAMCEST) incluidos en centros participantes de dos registros argentinos. Material y métodos: Se compararon pacientes con IAMCEST incluidos en 54 centros que participaron tanto en el registro SCAR (2011) como en el ARGEN-IAM-ST (2015). Resultados: Se analizaron 676 pacientes con IAMCEST; 222 del SCAR y 454 del ARGEN-IAM-ST No hubo cambios significativos en la edad y el género. Se observó una reducción significativa en el uso de fibrinolíticos, con un incremento de la angioplastia primaria. El shock cardiogénico se redujo a la mitad. No hubo diferencias en la mortalidad y de reinfarto durante la hospitalización. Conclusiones: Se observó una mayor indicación de angioplastia primaria y una disminución en el uso de fibrinolíticos. El shock cardiogénico se redujo significativamente en los últimos 5 años, sin cambios significativos en la mortalidad hospitalaria.


ABSTRACT Objectives: The aim of this study was to compare patientis with ST-segment elevation myocardial infarction (STEMI) included in centers participating of two registries in Argentina. Methods: STEMI patientis included in the 54 centers participating in the SCAR (2011) registry and in the ARGEN-IAM-ST (2015) registry were compared. Resultis: A total of 676 STEMI patientis were analyzed: 222 in the SCAR registry and 454 in the ARGEN-IAM-ST registry. There were no significant differences in age and sex. The use of fibrinolytic agentis was significantly lower and the use of primary percutaneous coronary intervention was significantly increased. The incidence of cardiogenic shock was 50% lower. There were no differences in mortality and reinfarction during hospitalization. Conclusions: The indication of primary percutaneous coronary intervention increased and the use of fibrinolytic agentis decreased. Cardiogenic shock decreased significantly in the last 5 years without significant changes in in-hospital mortality.

4.
Rev. argent. cardiol ; 86(4): 32-42, ago. 2018.
Artigo em Espanhol | LILACS-Express | ID: biblio-1003209

RESUMO

RESUMEN Introducción: Existe evidencia de que la reperfusión subóptima tiene impacto pronóstico a corto plazo en los pacientes con síndromes coronarios agudos con elevación del segmento ST, pero hay poca información sobre los factores vinculados a esta. Objetivos: Analizar los factores asociados a la reperfusión subóptima en pacientes con infarto agudo de miocardio con elevación del segmento S T, tratados con angioplastia primaria. Material y métodos: Se analizaron los pacientes con diagnóstico de infarto agudo de miocardio con elevación del segmento ST que recibieron tratamiento de revascularización con angioplastia primaria en el registro SCAR (Síndromes Coronarios Agudos en Argentina). Se analizó la asociación entre las variables clínicas clásicas, de laboratorio y el índice leucoglucémico con la reperfusión subóptima. Se definió reperfusión subóptima como TIMI III angiográfico pos-ATC con descenso del segmento ST en el ECG menor del 50%. Resultados: Se analizaron 258 pacientes con infarto agudo de miocardio con elevación del segmento ST, de los cuales 197 (76,4%) cumplieron los criterios de inclusión. De estos, el 8,6% (n = 17) tuvieron reperfusión subóptima. La incidencia de muerte intrahospitalaria entre los pacientes con reperfusión subóptima fue del 17,6% (n = 3) versus 1,7% (n = 3) en aquellos sin reperfusión subóptima (p = 0,007). En el análisis univariado, las variables asociadas a reperfusión subóptima fueron: diabetes (OR: 3,2 [IC95% 1,09-9,43] p = 0,026), revascularización previa (OR: 5,8 [1,74-19,07] p = 0,008), índice leucoglucé-mico (> 2159) (OR 3,7 [1,32-10,22] p = 0,009), y el tiempo dolor/balón (> 159 min) (OR: 6,9 [0,88-53] p = 0,045). El Killip-Kimbal al ingreso 3-4; la edad, mayor de 70 años; el sexo masculino, la hipertensión arterial, el tabaquismo, el infarto previo 0 anterior y el flujo TIMI 0-1 al ingreso no fueron significativos. Se estableció por curva ROC el mejor punto de corte para el índice leucoglucémico asociado a RSO en 2159 puntos (VPN = 94%), y el de tiempo dolor/balón en 159 min (VPN = 96%). En la regresión logística, solo la revascularización previa (OR: 5,3 [1,53-18,55]) y el índice leucoglucémico (OR: 3,2 [1,11-9,28]) estuvieron asociadas a reperfusión subóptima. Conclusiones: La reperfusión subóptima se asoció significativamente con mayor incidencia de muerte intrahospitalaria; mientras que la revascularización previa y el índice leucoglucémico (>2159) se asociaron con reperfusión subóptima.


ABSTRACT Background: Although there is evidence that suboptimal reperfusion has short-term prognostic impact in patients with ST-segment elevation acute coronary syndromes, there is little information about its associated factors. Objectives: The aim of this study was to analyze the factors associated with suboptimal reperfusion in patients with acute ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI). Methods: Patients from the SCAR (Acute Coronary Syndromes in Argentina) registry diagnosed with acute STEMI undergo-ing PCI were included in the study. The association of classical clinical and laboratory variables and the leuko-glycemic index with suboptimal reperfusion was analyzed. Suboptimal reperfusion was defined as post-PCI angiography TIMI III flow with less than 50% ST-segment decrease in the ECG. Results: Overall, 197 patients (76.4%) out of 258 patients with acute STEMI met the inclusion criteria. Among them, 8.6% (n: 17) had suboptimal reperfusion, with an incidence of in-hospital death of 17.6% (n: 3) versus 1.7% (n: 3) in patients without suboptimal reperfusion (p=0.007). In the univariate analysis, variables associated with suboptimal reperfusion were: diabetes [OR: 3.2 (1.09-9.43) p=0.026], previous revascularization [OR: 5.8 (1.74-19.07) p=0.008], leuko-glycemic index (> 2,159) [OR 3.7 (1.32-10.22) p=0.009], and pain-to-balloon time (>159 minutes) [OR: 6.9 (0.88- 53) p=0.045]. Age >70 years, male sex, high blood pressure, smoking, previous or anterior-wall infarction, and Killip and Kimball 3-4 and TIMI 0-1 flow on admission were not significantly different between patients with or without suboptimal reperfusion. Prior to the analysis, the cutoff point for the leuko-glycemic index associated with suboptimal reperfusion was established at 2,159 points by ROC curve analysis (NPV: 94%), and the pain-to-balloon time at 159 min (NPV: 96%). In logistic regression analysis, only previous revascular-ization [OR: 5.3 (1.53 -18.55)] and leuko-glycemic index [OR: 3.2 (1.11-9.28)] were associated with suboptimal reperfusion. Conclusions: Suboptimal reperfusion was significantly associated with a higher incidence of in-hospital death, while previous revascularization and the leuko-glycemic index (>2,159) were factors independently associated with suboptimal reperfusion.

5.
Cardiol J ; 23(3): 236-41, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-26503079

RESUMO

BACKGROUND: Microalbuminuria is a known risk factor for cardiovascular morbidity and mortality suggesting that it should be a marker of endothelial dysfunction. Albumin to creatinine ratio (ACR) is an available and rapid test for microalbuminuria determination, with a high correlation with the 24-h urine collection method. There is no prospective study that evaluates the prognostic value of ACR in patients with non ST-segment elevation acute coronary syndromes (NSTE-ACS). The purpose of our study was to detect the long-term prognostic value of ACR in patients with NSTE-ACS. METHODS: Albumin to creatinine ratio was estimated in 700 patients with NSTE-ACS at admission. Median follow-up time was 18 months. The best cutoff point of ACR for death or acute myocardial infarction was 20 mg/g. Twenty-two percent of patients had elevated ACR. RESULTS: By multivariable Cox regression analysis, ACR was an independent predictor of the clinical endpoint: odds ratio 5.8 (95% confidence interval [CI] 2-16), log-rank 2 p < 0.0001 in a model including age > 65 years, female gender, diabetes mellitus, creatinine clearance, glucose levels at admission, elevated cardiac markers (troponin T/CK-MB) and ST segment depression. The addition of ACR significantly improved GRACE score C-statistics from 0.69 (95% CI 0.59-0.83) to 0.77 (95% CI 0.65-0.88), SE 0.04, 2 p = 0.03, with a good calibration with both models. CONCLUSIONS: Albumin to creatinine ratio is an independent and accessible predictor of long-term adverse outcomes in NSTE-ACS, providing additional value for risk stratification.


Assuntos
Síndrome Coronariana Aguda/metabolismo , Albuminúria/urina , Creatinina/urina , Eletrocardiografia , Medição de Risco/métodos , Síndrome Coronariana Aguda/complicações , Síndrome Coronariana Aguda/epidemiologia , Idoso , Albuminúria/complicações , Albuminúria/diagnóstico , Argentina/epidemiologia , Biomarcadores/urina , Feminino , Seguimentos , Taxa de Filtração Glomerular , Humanos , Masculino , Pessoa de Meia-Idade , Morbidade/tendências , Estudos Prospectivos , Taxa de Sobrevida/tendências , Fatores de Tempo
6.
Rev. argent. cardiol ; 83(5): 406-411, oct. 2015. graf, tab
Artigo em Espanhol | LILACS-Express | ID: biblio-957653

RESUMO

Introducción: El registro sobre Síndromes Coronarios Agudos en Argentina (SCAR) analizó la evolución intrahospitalaria del infarto de miocardio en nuestro país en pacientes que contaban con diferentes coberturas del sistema de salud, lo cual ha llevado al presente subanálisis derivado del registro SCAR. Objetivo: Determinar la influencia de la cobertura médica en el pronóstico intrahospitalario del infarto de miocardio. Material y métodos: El registro SCAR fue un estudio transversal, prospectivo y multicéntrico, que incluyó 476 pacientes con diagnóstico de infarto agudo de miocardio con supradesnivel del segmento ST (IAMST). La cobertura médica se diferenció en prepaga, obra social, PAMI y sin cobertura (solo estatal). Resultados: El 80% de los IAMST recibieron reperfusión, el 75% por angioplastia transluminal coronaria primaria (ATCP). La ATCP fue más frecuente en quienes tenían prepaga [OR 5,5 (2,5-12,4); p < 0,001] y los pacientes con PAMI [OR 0,47 (0,24-087); p = 0,02] o sin cobertura recibieron menos ATCP [OR 0,34 (0,2-0,6); p < 0,001]. El 13% fueron derivados a otro centro, más frecuentemente si tenían PAMI (p = 0,002). El tiempo hasta la ATCP fue mayor en pacientes con PAMI [240 (88-370) min; p = 0,0005] y menor si tenían prepaga [80 (42-120) min; p < 0,001]. La mortalidad intrahospitalaria del IAMST fue del 8%, 2,8% con prepaga, 4,3% con cobertura estatal, 6,88% con obra social y 25% con PAMI (ANOVA < 0,001). Tener prepaga se asoció con una mortalidad menor [OR 0,27 (0,08-0,91); p = 0,035] y tener PAMI se asoció con una mortalidad mayor, aun ajustado por sexo, edad y comorbilidades [OR 2,40 (1,1-5,8); p = 0,05]. Conclusión: El tratamiento y la mortalidad del IAMST fueron diferentes según la cobertura médica.


Background: The Acute Coronary Syndromes in Argentina (SCAR) registry analyzed in-hospital myocardial infarction out-come in patients with different medical coverage provided by the healthcare system; this has led to the present subanalysis derived from the SCAR registry. Objective: The aim of this study was to determine the influence of medical coverage on myocardial infarction in-hospital prognosis. Methods: The SCAR registry was a cross-sectional, prospective, multicenter study including 476 patients with ST-segment elevation acute myocardial infarction (STEMI). Medical coverage was classified in prepaid health insurance, social security insurance, PAMI and without medical coverage (except public coverage). Results: Eighty percent of STEMI patients received reperfusion therapy, 75% by primary transluminal coronary angioplasty (PTCA). PTCA was more frequent in those with prepaid health insurance [OR 5.5 (2.5-12.4); p<0.001] and less frequent in PAMI patients [OR 0.47 (0.24-0.87), p=0.02] or in those without any medical coverage [OR=0.34 (0.2-0.6), p<0.001]. Thirteen percent of patients were transferred to another hospital, more frequently if they were PAMI patients (p=0.002). Time to PTCA was longer in patients with PAMI [240 (88-370) min, p=0.0005] and shorter in patients with prepaid health insurance [80 (42-120) min, p<0.001]. Overall in-hospital STEMI mortality was 8%, 2.8% in patients with prepaid health insurance, 4.3% in patients with public medical coverage, 6.88% in patients with social security insurance and 25% in patients covered by PAMI (ANOVA <0.001). Mortality was significantly lower in patients with prepaid health insurance [OR=0.27 (0.08-0.91), p=0.035] and higher in patients with PAMI, even after adjusting by sex, age and comorbidities [OR 2.40 (1.1-5.8), p=0.05]. Conclusion: STEMI treatment and mortality were different according to the type of medical coverage.

7.
Rev. argent. cardiol ; 83(4): 300-304, ago. 2015. graf, tab
Artigo em Espanhol | LILACS-Express | ID: biblio-957630

RESUMO

Introducción: En nuestro medio se desconoce cuál ha sido la influencia de la evidencia clínica sobre las estrategias implementadas en el tratamiento de los síndromes coronarios agudos sin elevación del segmento ST (SCASEST). Objetivos: Evaluar la variación de las características clínicas, las estrategias adoptadas, las conductas terapéuticas y los eventos hospitalarios de los SCASEST en centros que participaron en dos registros realizados en la Argentina. Material y métodos: Se compararon pacientes incluidos en centros que participaron en los registros STRATEG-SIA (1999) y SCAR (Síndromes Coronarios Agudos en Argentina - 2011). Resultados: Se analizaron 238 pacientes del registro STRATEG-SIA y 452 del SCAR incluidos en 36 centros. La mayoría eran de género masculino y menores de 65 años (SCAR 57%, STRATEG-SIA 54%; p = ns). El grupo SCAR presentó mayor prevalencia de hipertensión arterial (75% vs. 60%; p = 0,001), dislipidemia (63% vs. 51%; p = 0,003), insuficiencia cardíaca crónica (10,5% vs. 4,6%; p = 0,02) y revascularización coronaria previa (30% vs. 17%; p = 0,001). Con una proporción mayor de puntaje TIMI de riesgo moderado y alto (3-4: 48% vs. 37%; 5-7: 18% vs. 8%; p = 0,0001), la coronariografía fue más frecuente en el SCAR (71% vs. 50%; p = 0,0001), duplicándose la angioplastia coronaria y reduciéndose a la mitad las cirugías de revascularización miocárdica. No hubo diferencias significativas en la tasa intrahospitalaria de muerte e infarto (7,2% vs. 5,9%; p = ns). Conclusiones: Los pacientes del registro SCAR (2011) representan un grupo de mayor riesgo. Las diferencias en las tasas de eventos hospitalarios no fueron estadísticamente significativas.


Background: The influence of clinical evidence on strategies implemented in the treatment of non-ST-segment elevation acute coronary syndromes (NSTEACS) is not known in our setting. Objectives: The aim of this study was to evaluate the differences in clinical characteristics, strategies adopted, therapeutic management and in-hospital events of NSTEACS in participating centers from two registries in Argentina. Methods: Patients included in participating centers of the STRATEG-SIA registry (1999) and SCAR registry (Síndromes Coronarios Agudos en Argentina - 2011) were compared. Results: We analyzed 238 patients of the STRATEG-SIA registry and 452 of the SCAR registry in 36 centers. Most patients were men and <65 years (SCAR 57%, STRATEG-SIA 54%; p=ns). The SCAR group presented higher prevalence of hypertension (75% vs. 60%; p=0.001), dyslipidemia (63% vs. 51%; p=0.003), chronic heart failure (10.5% vs. 4.6%; p=0.02) and history of myocardial revascularization (30% vs. 17%; p=0.001). In the SCAR registry, the proportion of moderate and high-risk patients (TIMI risk score 3-4: 48% vs. 37%; 5-7: 18% vs. 8%; p=0.0001) was higher and coronary angiography was more frequent (71% vs. 50%; p=0.0001), with a twofold increase in the proportion of percutaneous coronary interventions and 50% reduction in the number of myocardial revascularization surgeries. There were no significant differences in the rate of mortality and myocardial infarction during hospitalization (7.2% vs. 5.9%; p=ns). Conclusions: Patients of the SCAR (2011) registry represent a group at higher risk. The differences in the rates of in-hospital events were not statistically significant.

8.
Rev. argent. cardiol ; 82(6): 500-505, dic. 2014. tab
Artigo em Espanhol | LILACS-Express | ID: lil-750558

RESUMO

Introducción: Se conoce que la leucocitosis y la hiperglucemia se correlacionan a corto plazo con peor pronóstico en pacientes con síndrome coronario agudo, pero su novel relación, denominada índice leucoglucémico (ILG), se ha evaluado escasamente. Objetivos: Analizar el valor pronóstico del ILG en pacientes con infarto agudo de miocardio con elevación del segmento ST (IAMCEST) y su valor agregado a los puntajes de riesgo clásicos. Material y métodos: Se analizaron los pacientes con diagnóstico de IAMCEST del Registro Multicéntrico SCAR (Síndromes Coronarios Agudos en Argentina). El punto final analizado fue la muerte o Killip Kimball 3-4 (KK 3-4) en el período hospitalario. Se analizó el ILG tanto como variable continua como en cuartiles según los valores de los percentiles 25, 50 y 75. Resultados: Se analizaron 405 de 476 pacientes con diagnóstico final de IAMCEST. La presencia del punto final fue significativamente creciente por cuartiles de ILG: 0%, 7,60%, 9,30% y 30,60% (p < 0,0001). El área bajo la curva ROC del ILG para el punto final combinado fue de 0,77 [(IC 95% 0,71-0,88); p = 0,0001]; el mejor valor de corte pronóstico fue de 1.000. La presencia de muerte o KK 3-4 fue del 0% y del 13% en los IAMCEST con ILG menor o mayor de 1.000, respectivamente. En un modelo de regresión logística multivariado, el ILG se asoció independientemente con muerte o KK 3-4. El área bajo la curva ROC del puntaje TIMI para IAMCEST fue de 0,58. El agregado del ILG incrementó su capacidad discriminatoria a 0,66 (p = 0,001). Conclusiones: El ILG demostró que es un predictor independiente de mala evolución en el IAMCEST (muerte o KK 3-4), con valor aditivo al puntaje TIMI.


Background: Leukocytosis and hyperglycemia correlate with worse short-term prognosis in patients with acute coronary syndrome, but their new relationship, called leuko-glycemic index (LGI), has been scarcely evaluated. Objectives: The aim of this study was to analyze the prognostic value of LGI in patients with ST-segment-elevation acute myocardial infarction (STEMI) and its added value to classical risk scores. Methods: Patients diagnosed with STEMI from the SCAR (Acute Coronary Syndromes in Argentina) Multicenter Registry were analyzed. The final endpoint was death or in-hospital Killip-Kimball 3-4 (KK 3-4). The LGI was analyzed as a continu-ous variable and in quartiles according to 25, 50 and 75 percentile values. Results: The study evaluated 405 out of 476 patients with final STEMI diagnosis. Presence of the primary endpoint significantly increased per LGI quartile: 0%, 7.60%, 9.30% and 30.60% (p < 0.0001). The LGI area under the ROC curve for the composite endpoint was 0.77 [(95% CI 0.71-0.88); p = 0.0001]; the best prognostic cut-off value was 1000. Presence of death or KK 3-4 was 0% and 13% in STEMI patients with LGI below or above 1000, respectively In a multivariate logistic regression model, LGI was independently associated with death or KK 3-4. The area under the ROC curve of the TIMI risk score for STEMI was 0.58. The addition of LGI increased its discriminatory capacity to 0.66 (p = 0.001). Conclusions: The LGI was an independent predictor of adverse outcome in STEMI patients (death or KK 3-4), adding prognostic value to the TIMI risk score.

9.
Rev. argent. cardiol ; 82(5): 373-380, oct. 2014. graf, tab
Artigo em Espanhol | LILACS-Express | ID: lil-734526

RESUMO

Introducción: Las mediciones de calidad ayudan a cuantificar la distancia entre la atención en salud que se brinda y la que se debería brindar. Existen mediciones específicas sobre la calidad de la atención del infarto de miocardio que permiten uniformar los datos de calidad que toda institución debería medir para autoevaluarse y compararse con otras. Objetivo: Analizar los datos de calidad de la atención del infarto en nuestro país utilizando los datos del Registro Multicéntrico SCAR (Síndromes Coronarios Agudos en Argentina). Material y métodos: Se analizaron los datos de calidad de atención del infarto de miocardio de los pacientes de la base de datos del Registro Multicéntrico SCAR utilizando definiciones del documento "ACC/AHA 2008 performance measures for adults with ST-elevation and non-ST-elevation myocardial infarction". Resultados: Se analizaron 751 casos de infarto de miocardio con datos completos sobre indicadores de calidad. El uso de aspirina, betabloqueantes, estatinas y antagonistas de la angiotensina fue cercano al 90%. La excepción fue el uso de clopidogrel, que fue del 72,5% en quienes no recibieron reperfusión mecánica. Se relevó la función ventricular durante la internación en el 90,2% de los casos. Recibieron alguna estrategia de reperfusión el 90,1% de los infartos con elevación del segmento ST y menos de 12 horas de evolución. El tiempo puerta-balón fue < 90 minutos en el 50,8% de los casos, mientras que el tiempo puerta-aguja fue < 30 minutos en el 40,5%. Conclusiones: Globalmente se observaron valores altos de cumplimiento en los tratamientos farmacológicos y de reperfusión, excepto en el uso de clopidogrel sin revascularización mecánica. Se observó un cumplimiento bajo en los tiempos apropiados de los tratamientos de reperfusión.


Introduction: Quality assessments help to quantify the gap between healthcare provision and what should be awarded. There are specific measurements on quality of medical care for myocardial infarction which standardize the quality information that every institution should determine for self-assessment and for comparison with others. Objective: The aim of this study was to analyze quality of care for myocardial infarction data in our country using the SCAR (Acute Coronary Syndromes in Argentina) Multicenter Registry. Methods: Quality of care data for myocardial infarction was analyzed in patients included in the database of the SCAR Multicenter Registry using definitions of the "ACC/AHA 2008 performance measures for adults with ST-elevation and non-ST-elevation myocardial infarction" document. Results: The study analyzed 751 myocardial infarction cases with complete data on quality indicators. Aspirin, betablockers, statins and angiotensin antagonists were used in nearly 90% of patients. The exception was clopidogrel which was used in 72.5% of patients not receiving mechanical reperfusion. Ventricular function was assessed during hospitalization in 90.2% of cases. A reperfusion strategy was used in 90.1% of ST-segment-elevation infarctions and less than 12-hour evolution. Door-to-balloon time was < 90 minutes in 50.8% of cases, while door-to-needle time was < 40.5%. Conclusions: Overall, there was high compliance to pharmacological and reperfusion treatments except in the use of clopidogrel without mechanical revascularization, and low compliance to the appropriate times of reperfusion therapy.

10.
Rev. argent. cardiol ; 82(5): 373-380, oct. 2014. graf, tab
Artigo em Espanhol | BINACIS | ID: bin-131316

RESUMO

Introducción: Las mediciones de calidad ayudan a cuantificar la distancia entre la atención en salud que se brinda y la que se debería brindar. Existen mediciones específicas sobre la calidad de la atención del infarto de miocardio que permiten uniformar los datos de calidad que toda institución debería medir para autoevaluarse y compararse con otras. Objetivo: Analizar los datos de calidad de la atención del infarto en nuestro país utilizando los datos del Registro Multicéntrico SCAR (Síndromes Coronarios Agudos en Argentina). Material y métodos: Se analizaron los datos de calidad de atención del infarto de miocardio de los pacientes de la base de datos del Registro Multicéntrico SCAR utilizando definiciones del documento "ACC/AHA 2008 performance measures for adults with ST-elevation and non-ST-elevation myocardial infarction". Resultados: Se analizaron 751 casos de infarto de miocardio con datos completos sobre indicadores de calidad. El uso de aspirina, betabloqueantes, estatinas y antagonistas de la angiotensina fue cercano al 90%. La excepción fue el uso de clopidogrel, que fue del 72,5% en quienes no recibieron reperfusión mecánica. Se relevó la función ventricular durante la internación en el 90,2% de los casos. Recibieron alguna estrategia de reperfusión el 90,1% de los infartos con elevación del segmento ST y menos de 12 horas de evolución. El tiempo puerta-balón fue < 90 minutos en el 50,8% de los casos, mientras que el tiempo puerta-aguja fue < 30 minutos en el 40,5%. Conclusiones: Globalmente se observaron valores altos de cumplimiento en los tratamientos farmacológicos y de reperfusión, excepto en el uso de clopidogrel sin revascularización mecánica. Se observó un cumplimiento bajo en los tiempos apropiados de los tratamientos de reperfusión.(AU)


Introduction: Quality assessments help to quantify the gap between healthcare provision and what should be awarded. There are specific measurements on quality of medical care for myocardial infarction which standardize the quality information that every institution should determine for self-assessment and for comparison with others. Objective: The aim of this study was to analyze quality of care for myocardial infarction data in our country using the SCAR (Acute Coronary Syndromes in Argentina) Multicenter Registry. Methods: Quality of care data for myocardial infarction was analyzed in patients included in the database of the SCAR Multicenter Registry using definitions of the "ACC/AHA 2008 performance measures for adults with ST-elevation and non-ST-elevation myocardial infarction" document. Results: The study analyzed 751 myocardial infarction cases with complete data on quality indicators. Aspirin, betablockers, statins and angiotensin antagonists were used in nearly 90% of patients. The exception was clopidogrel which was used in 72.5% of patients not receiving mechanical reperfusion. Ventricular function was assessed during hospitalization in 90.2% of cases. A reperfusion strategy was used in 90.1% of ST-segment-elevation infarctions and less than 12-hour evolution. Door-to-balloon time was < 90 minutes in 50.8% of cases, while door-to-needle time was < 40.5%. Conclusions: Overall, there was high compliance to pharmacological and reperfusion treatments except in the use of clopidogrel without mechanical revascularization, and low compliance to the appropriate times of reperfusion therapy.(AU)

11.
Rev. argent. cardiol ; 82(4): 275-284, ago. 2014. tab
Artigo em Espanhol | LILACS-Express | ID: lil-734511

RESUMO

Introducción Los registros de síndromes coronarios agudos realizados por la Sociedad Argentina de Cardiología aportan información actualizada y comparativa sobre su evolución, cuyo análisis permite conocer la tasa de mortalidad, diferentes patrones de tratamiento regionales y evaluar la relación entre los resultados y variables demográficas, características clínicas y terapéutica aplicada en la “vida real”. Objetivos Analizar las características clínicas, terapéuticas y evolutivas del infarto agudo de miocardio con supradesnivel del segmento ST (IAMST) del registro multicéntrico realizado por la Sociedad Argentina de Cardiología durante 2011. Material y métodos Se analizaron pacientes con diagnóstico de IAMST incluidos en el registro multicéntrico SCAR (Síndromes Coronarios Agudos en Argentina). Se compararon datos de centros que participaron en los registros de 2005 y de 2011. Resultados Se incluyeron 476 pacientes. Una cuarta parte fueron mujeres, la edad media fue de 61 ± 12,3 años, el 70% recibió tratamiento de reperfusión: 20% (n = 92) con trombolíticos y 50% (n = 238) con angioplastia primaria. La mortalidad hospitalaria de los IAMST fue del 8%. Fueron predictores independientes de muerte la edad mayor de 70 años (OR 2, IC 95% 1,2-3,3; p = 0,003), no haber recibido tratamiento de reperfusión (OR 1,72, IC 95% 1,1-2,0; p = 0,01) y el shock cardiogénico (OR 37, IC 95% 12-117; p < 0,0001). Comparando los mismos centros, en 2011 se redujo en un 30% el número de casos que no recibieron tratamiento de reperfusión, con un incremento del uso de la angioplastia primaria [OR 3,7 (IC 95% 1,6-4; p < 0,001)]. Se detectó también una reducción de la mortalidad hospitalaria [OR 0,40 (IC 95% 0,23-0,83; p = 0,01)]. Conclusiones El 70% de los pacientes con IAMST del SCAR recibió tratamiento de reperfusión, mientras que la mortalidad fue del 8%. Respecto de 2005 se observó, entre otros hallazgos, un incremento de la angioplastia primaria y una disminución de la mortalidad hospitalaria.


Introduction Acute coronary syndrome registries made by the Argentine Society of Cardiology provide current and comparative information on their evolution, whose analysis allows to know mortality rate and different regional treatment patterns, and to evaluate the relationship between outcomes and demographic variables, clinical characteristics and therapy applied in “real life”. Objectives To analyze the clinical, therapeutic and outcome characteristics of ST segment elevation acute myocardial infarction (STEMI) included in a multicenter registry conducted by the Argentine Society of Cardiology in 2011. Methods Patients diagnosed with STEMI included in the multicenter SCAR (Acute Coronary Syndromes in Argentina) registry were analyzed. Data from centers that participated in the 2005 and 2011 registries were compared. Results The study included 476 patients. Twenty-five percent of patients were women, mean age was 61 ± 12.3 years, and 70% received reperfusion therapy: 20% (n = 92) with thrombolytics and 50% (n = 238) with primary angioplasty. In-hospital mortality rate due to STEMI was 8%. Independent predictors of death were age over 70 years (OR 2, 95% CI 1.2-3.3, p = 0.003), not having received reperfusion therapy (OR 1.72, 95% CI 1.1-2.0, p = 0.01) and cardiogenic shock (OR 37, 95% CI 12-117, p < 0.0001). Comparison of the same centers showed that in 2011 the number of cases that did not receive reperfusion therapy was reduced by 30%, with increased use of primary angioplasty [OR 3.7 (95% CI 1.6-4, p < 0.001)]. A reduction of in-hospital mortality [OR 0.40 (95% CI 0.23-0.83, p = 0.01)] was also identified. Conclusions Seventy percent of patients with STEMI included in the SCAR registry received reperfusion therapy, while mortality rate was 8%. Compared with 2005, an increase of primary angioplasty and decreased in-hospital mortality was found, among other findings.

12.
Rev. argent. cardiol ; 82(4): 275-284, ago. 2014. tab
Artigo em Espanhol | BINACIS | ID: bin-131331

RESUMO

Introducción Los registros de síndromes coronarios agudos realizados por la Sociedad Argentina de Cardiología aportan información actualizada y comparativa sobre su evolución, cuyo análisis permite conocer la tasa de mortalidad, diferentes patrones de tratamiento regionales y evaluar la relación entre los resultados y variables demográficas, características clínicas y terapéutica aplicada en la ôvida realö. Objetivos Analizar las características clínicas, terapéuticas y evolutivas del infarto agudo de miocardio con supradesnivel del segmento ST (IAMST) del registro multicéntrico realizado por la Sociedad Argentina de Cardiología durante 2011. Material y métodos Se analizaron pacientes con diagnóstico de IAMST incluidos en el registro multicéntrico SCAR (Síndromes Coronarios Agudos en Argentina). Se compararon datos de centros que participaron en los registros de 2005 y de 2011. Resultados Se incluyeron 476 pacientes. Una cuarta parte fueron mujeres, la edad media fue de 61 ± 12,3 años, el 70% recibió tratamiento de reperfusión: 20% (n = 92) con trombolíticos y 50% (n = 238) con angioplastia primaria. La mortalidad hospitalaria de los IAMST fue del 8%. Fueron predictores independientes de muerte la edad mayor de 70 años (OR 2, IC 95% 1,2-3,3; p = 0,003), no haber recibido tratamiento de reperfusión (OR 1,72, IC 95% 1,1-2,0; p = 0,01) y el shock cardiogénico (OR 37, IC 95% 12-117; p < 0,0001). Comparando los mismos centros, en 2011 se redujo en un 30% el número de casos que no recibieron tratamiento de reperfusión, con un incremento del uso de la angioplastia primaria [OR 3,7 (IC 95% 1,6-4; p < 0,001)]. Se detectó también una reducción de la mortalidad hospitalaria [OR 0,40 (IC 95% 0,23-0,83; p = 0,01)]. Conclusiones El 70% de los pacientes con IAMST del SCAR recibió tratamiento de reperfusión, mientras que la mortalidad fue del 8%. Respecto de 2005 se observó, entre otros hallazgos, un incremento de la angioplastia primaria y una disminución de la mortalidad hospitalaria.(AU)


Introduction Acute coronary syndrome registries made by the Argentine Society of Cardiology provide current and comparative information on their evolution, whose analysis allows to know mortality rate and different regional treatment patterns, and to evaluate the relationship between outcomes and demographic variables, clinical characteristics and therapy applied in ôreal lifeö. Objectives To analyze the clinical, therapeutic and outcome characteristics of ST segment elevation acute myocardial infarction (STEMI) included in a multicenter registry conducted by the Argentine Society of Cardiology in 2011. Methods Patients diagnosed with STEMI included in the multicenter SCAR (Acute Coronary Syndromes in Argentina) registry were analyzed. Data from centers that participated in the 2005 and 2011 registries were compared. Results The study included 476 patients. Twenty-five percent of patients were women, mean age was 61 ± 12.3 years, and 70% received reperfusion therapy: 20% (n = 92) with thrombolytics and 50% (n = 238) with primary angioplasty. In-hospital mortality rate due to STEMI was 8%. Independent predictors of death were age over 70 years (OR 2, 95% CI 1.2-3.3, p = 0.003), not having received reperfusion therapy (OR 1.72, 95% CI 1.1-2.0, p = 0.01) and cardiogenic shock (OR 37, 95% CI 12-117, p < 0.0001). Comparison of the same centers showed that in 2011 the number of cases that did not receive reperfusion therapy was reduced by 30%, with increased use of primary angioplasty [OR 3.7 (95% CI 1.6-4, p < 0.001)]. A reduction of in-hospital mortality [OR 0.40 (95% CI 0.23-0.83, p = 0.01)] was also identified. Conclusions Seventy percent of patients with STEMI included in the SCAR registry received reperfusion therapy, while mortality rate was 8%. Compared with 2005, an increase of primary angioplasty and decreased in-hospital mortality was found, among other findings.(AU)

13.
J Cardiothorac Surg ; 9: 57, 2014 Mar 22.
Artigo em Inglês | MEDLINE | ID: mdl-24655354

RESUMO

BACKGROUND: Invasion of the chest wall per se is not a contraindication for tumor resection in non-small cell lung cancer (NSCLC), provided there is no mediastinal lymph node or vital structure involvement. Although widely known to Brazilian surgeons, the 'resection in bird cage' technique has never been widely studied in terms of patient survival. Thus, the objective of this study was to evaluate the postoperative consequences and overall survival of extra-musculoperiosteal resection compared with en-bloc resection in NSCLC patients with invasion of the endothoracic fascia. METHODS: Between January 1990 and December 2009, 33 NSCLC patients with invasion of the thoracic wall who underwent pulmonary resection were retrospectively analyzed. Of the 33 patients evaluated, 20 patients underwent en-bloc resection and 13 underwent 'resection in bird cage.' For each patient, a retrospective case note review was made. RESULTS: The median age at surgery, gender, indication, rate of comorbidities, tumor size and the degree of uptake in the costal margin were similar for both groups. The rate of postoperative complications and the duration of hospitalization did not differ between the groups. Regarding the outcome variables, the disease-free interval, rate of local recurrence, metastasis-free time after surgery, overall mortality rate, mortality rate related to metastatic disease, duration following surgery in which deaths occurred, and overall survival were also similar between groups. The cumulative survival curves between the 'resection in bird cage' and en-bloc resection and between stages Ia + Ib and IIb + IIIa + IV were not significantly different (p = 0.68 and p = 0.64, respectively). The cumulative metastasis-free survival curves were not significantly different between the two types of surgery (p = 0.38). CONCLUSIONS: In NSCLC patients with invasion of the endothoracic fascia, 'resection in bird cage' is a less aggressive procedure that yields similar results in terms of morbidity and mortality compared with en-bloc resection. Thus, 'resection in bird cage' meets the oncologic principles of resection and does not adversely affect the patients in terms of cure.


Assuntos
Neoplasias Pulmonares/cirurgia , Procedimentos Cirúrgicos Pulmonares/métodos , Parede Torácica/cirurgia , Adulto , Idoso , Feminino , Humanos , Neoplasias Pulmonares/patologia , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Parede Torácica/patologia
14.
Rev. argent. cardiol ; 81(3): 251-257, jun. 2013. graf, tab
Artigo em Espanhol | LILACS-Express | ID: lil-694869

RESUMO

Introducción y Objetivo La trombosis venosa profunda (TVP) y la tromboembolia de pulmón (TEP) son las dos formas de presentación de la enfermedad tromboembólica venosa (ETEV), que constituye la tercera causa de morbimortalidad cardiovascular. Con el objetivo de obtener datos nacionales sobre esta patología, el Consejo de Emergencias Cardiovasculares y el Área de Investigación de la Sociedad Argentina de Cardiología realizaron este registro prospectivo de pacientes con ETEV confirmada, en el que participaron 54 centros durante un año. Material y métodos El registro incluyó pacientes con diagnóstico confirmado de ETEV en forma prospectiva, continua y consecutiva durante el período 2009-2010 en los 54 centros participantes de Capital Federal e Interior del país (n = 26 y 28, respectivamente) y cuyos datos individuales se registraron en una ficha con formato electrónico. Resultados Se incluyeron 181 pacientes con una mediana de edad de 66 años (53-79); el 59% eran mujeres. Se diagnosticó TEP en el 34%, TVP en el 33% y TEP + TVP en el 33%. Los factores de riesgo más prevalentes fueron: reposo prolongado en el 42%, cáncer en el 20%, antecedentes de ETEV en el 10% y ninguno en el 9%. Todas las TVP se diagnosticaron por Doppler venoso. El diagnóstico de TEP se realizó por tomografía helicoidal (86%), centellograma de ventilación/perfusión (16%) y arteriografía (0,8%). El 70% recibió heparina de bajo peso molecular, el 40% heparina no fraccionada, el 11% trombolíticos y el 10% no recibió tratamiento. Se empleó filtro de la vena cava en el 12% de casos y asistencia respiratoria mecánica en el 9%. Se observó TEP recurrente en el 4%, shock en el 14% y la mortalidad hospitalaria fue del 7%. Conclusiones El reposo prolongado fue el factor de riesgo más prevalente. Solo el 9% no evidenció factores de riesgo conocidos. La tomografía helicoidal fue el método más utilizado para el diagnóstico de TEP. La heparina de bajo peso molecular fue el tratamiento de elección de la ETEV. Los trombolíticos se emplearon en el 11% de las TEP y el filtro de la vena cava en el 12% de las ETEV. La mortalidad hospitalaria de la ETEV fue del 7%.


Background and Objective Venous thromboembolism (VTE) with its two presentations: deep vein thrombosis (DVT) and pulmonary embolism (PE) is the third leading cause of cardiovascular morbidity and mortality. To obtain national data on this pathology, the Council of Cardiovascular Emergencies and the Research Section of the Argentine Society of Cardiology conducted a prospective registry of patients with confirmed VTE in 54 centers during one year. Methods Patients with confirmed VTE were included in a prospective, consecutive and continuous registry during 2009-2010 in 54 participating centers in Capital Federal and the rest of the country (n = 26 and 28, respectively). Individual patient data were registered in an electronic form. Results One hundred and eighty one patients with median age of 66 years (53-79), 59% of which were women, were included in the study. Pulmonary embolism was diagnosed in 34%, DVT in 33% and PE + DVT in 33% of patients. The most prevalent risk factors were prolonged rest in 42% of cases, cancer in 20%, history of VTE in 10% and none in 9%. All DVT were diagnosed by venous Doppler. Pulmonary embolism was diagnosed by helical CT scan (86%), ventilation/perfusion scintigraphy (16%) and arteriography (0.8%). Seventy percent of patients received low molecular weight heparin, 40% unfractionated heparin, 11% thrombolytic agents and 10% had no treatment. Vena cava filter was used in 12% of cases and mechanical ventilation in 9%. Recurrent PE was observed in 4% of patients, shock in 14% and hospital mortality was 7%. Conclusions Prolonged rest was the most prevalent risk factor. Only 9% of patients showed no known risk factors. Helical CT scan was the preferred method for PE diagnosis. Low molecular weight heparin was the treatment of choice for VTE. Thrombolytics were used in 11% of PE patients and vena cava filter in 12% of VTE patients. VTE hospital mortality was 7%.

15.
Rev. argent. cardiol ; 81(3): 251-257, jun. 2013. graf, tab
Artigo em Espanhol | BINACIS | ID: bin-130718

RESUMO

Introducción y Objetivo La trombosis venosa profunda (TVP) y la tromboembolia de pulmón (TEP) son las dos formas de presentación de la enfermedad tromboembólica venosa (ETEV), que constituye la tercera causa de morbimortalidad cardiovascular. Con el objetivo de obtener datos nacionales sobre esta patología, el Consejo de Emergencias Cardiovasculares y el Area de Investigación de la Sociedad Argentina de Cardiología realizaron este registro prospectivo de pacientes con ETEV confirmada, en el que participaron 54 centros durante un año. Material y métodos El registro incluyó pacientes con diagnóstico confirmado de ETEV en forma prospectiva, continua y consecutiva durante el período 2009-2010 en los 54 centros participantes de Capital Federal e Interior del país (n = 26 y 28, respectivamente) y cuyos datos individuales se registraron en una ficha con formato electrónico. Resultados Se incluyeron 181 pacientes con una mediana de edad de 66 años (53-79); el 59% eran mujeres. Se diagnosticó TEP en el 34%, TVP en el 33% y TEP + TVP en el 33%. Los factores de riesgo más prevalentes fueron: reposo prolongado en el 42%, cáncer en el 20%, antecedentes de ETEV en el 10% y ninguno en el 9%. Todas las TVP se diagnosticaron por Doppler venoso. El diagnóstico de TEP se realizó por tomografía helicoidal (86%), centellograma de ventilación/perfusión (16%) y arteriografía (0,8%). El 70% recibió heparina de bajo peso molecular, el 40% heparina no fraccionada, el 11% trombolíticos y el 10% no recibió tratamiento. Se empleó filtro de la vena cava en el 12% de casos y asistencia respiratoria mecánica en el 9%. Se observó TEP recurrente en el 4%, shock en el 14% y la mortalidad hospitalaria fue del 7%. Conclusiones El reposo prolongado fue el factor de riesgo más prevalente. Solo el 9% no evidenció factores de riesgo conocidos. La tomografía helicoidal fue el método más utilizado para el diagnóstico de TEP. La heparina de bajo peso molecular fue el tratamiento de elección de la ETEV. Los trombolíticos se emplearon en el 11% de las TEP y el filtro de la vena cava en el 12% de las ETEV. La mortalidad hospitalaria de la ETEV fue del 7%.(AU)


Background and Objective Venous thromboembolism (VTE) with its two presentations: deep vein thrombosis (DVT) and pulmonary embolism (PE) is the third leading cause of cardiovascular morbidity and mortality. To obtain national data on this pathology, the Council of Cardiovascular Emergencies and the Research Section of the Argentine Society of Cardiology conducted a prospective registry of patients with confirmed VTE in 54 centers during one year. Methods Patients with confirmed VTE were included in a prospective, consecutive and continuous registry during 2009-2010 in 54 participating centers in Capital Federal and the rest of the country (n = 26 and 28, respectively). Individual patient data were registered in an electronic form. Results One hundred and eighty one patients with median age of 66 years (53-79), 59% of which were women, were included in the study. Pulmonary embolism was diagnosed in 34%, DVT in 33% and PE + DVT in 33% of patients. The most prevalent risk factors were prolonged rest in 42% of cases, cancer in 20%, history of VTE in 10% and none in 9%. All DVT were diagnosed by venous Doppler. Pulmonary embolism was diagnosed by helical CT scan (86%), ventilation/perfusion scintigraphy (16%) and arteriography (0.8%). Seventy percent of patients received low molecular weight heparin, 40% unfractionated heparin, 11% thrombolytic agents and 10% had no treatment. Vena cava filter was used in 12% of cases and mechanical ventilation in 9%. Recurrent PE was observed in 4% of patients, shock in 14% and hospital mortality was 7%. Conclusions Prolonged rest was the most prevalent risk factor. Only 9% of patients showed no known risk factors. Helical CT scan was the preferred method for PE diagnosis. Low molecular weight heparin was the treatment of choice for VTE. Thrombolytics were used in 11% of PE patients and vena cava filter in 12% of VTE patients. VTE hospital mortality was 7%.(AU)

16.
Medicina (B Aires) ; 72(2): 135-42, 2012.
Artigo em Espanhol | MEDLINE | ID: mdl-22522857

RESUMO

Hyperglycemia with or without pre-existing diabetes mellitus, occurs frequently in the setting of acute coronary syndrome. Previous studies have demonstrated that hyperglycemia is highly prevalent and is associated with an increased risk of hospital complications and death. The underlying pathophysiology related an adverse clinical outcome to hyperglycemia is unclear, and it is uncertain whether increased serum glucose is simply a marker of adverse outcomes or their cause. Detrimental effects of hyperglycemia on the cardiovascular system are multiple. Glycemia control with insulin would prevent adverse outcomes. Numerous glucose-control protocols have been developed and tested proving to be safe and effective. In an initiative from the Emergency Council of the Argentine Society of Cardiology, local experts analyzed the management of hyperglycemia in acute coronary syndrome. The main objective of the prevent statement is to summarize the current state of knowledge on glycemic control, and to offer general recommendations regarding glucose management in the coronary care unit.


Assuntos
Síndrome Coronariana Aguda/etiologia , Diabetes Mellitus/fisiopatologia , Hiperglicemia/complicações , Glicemia/análise , Protocolos Clínicos , Humanos , Hiperglicemia/tratamento farmacológico , Hiperglicemia/fisiopatologia , Insulina/uso terapêutico
17.
Medicina (B.Aires) ; 72(2): 135-142, abr. 2012. tab
Artigo em Espanhol | LILACS | ID: lil-639667

RESUMO

La hiperglucemia con o sin diabetes preexistente es un hallazgo frecuente en pacientes que cursan un síndrome coronario agudo. Estudios previos han demostrado que la hiperglucemia es altamente prevalente y se asocia a un mayor riesgo de muerte y complicaciones hospitalarias. Los mecanismos fisiopatológicos mediante los cuales la hiperglucemia provoca resultados adversos no son claros, y se desconoce si es un marcador de eventos o su causa. Los efectos perjudiciales de la hiperglucemia en el sistema cardiovascular son múltiples, y el control de los niveles de glucosa con insulina parece mejorar el pronóstico en estos pacientes. Se han desarrollado numerosos protocolos para el control de glucemia que demostraron ser seguros y efectivos. En una iniciativa originada en el Consejo de Emergencias de la Sociedad Argentina de Cardiología, se convocó a expertos de nuestro medio con el propósito de debatir estrategias para el control de la glucemia en pacientes que cursan un síndrome coronario agudo. Este documento refleja lo discutido en este evento académico con la intención de resumir los principales aspectos del control de la glucemia y ofrecer recomendaciones generales de tratamiento en la Unidad Coronaria.


Hyperglycemia with or without pre-existing diabetes mellitus, occurs frequently in the setting of acute coronary syndrome. Previous studies have demonstrated that hyperglycemia is highly prevalent and is associated with an increased risk of hospital complications and death. The underlying pathophysiology related an adverse clinical outcome to hyperglycemia is unclear, and it is uncertain whether increased serum glucose is simply a marker of adverse outcomes or their cause. Detrimental effects of hyperglycemia on the cardiovascular system are multiple. Glycemia control with insulin would prevent adverse outcomes. Numerous glucose-control protocols have been developed and tested proving to be safe and effective. In an initiative from the Emergency Council of the Argentine Society of Cardiology, local experts analyzed the management of hyperglycemia in acute coronary syndrome. The main objective of the prevent statement is to summarize the current state of knowledge on glycemic control, and to offer general recommendations regarding glucose management in the coronary care unit.


Assuntos
Humanos , Síndrome Coronariana Aguda/etiologia , Diabetes Mellitus/fisiopatologia , Hiperglicemia/complicações , Glicemia/análise , Protocolos Clínicos , Hiperglicemia/tratamento farmacológico , Hiperglicemia/fisiopatologia , Insulina/uso terapêutico
18.
Medicina (B.Aires) ; 72(2): 135-142, abr. 2012. tab
Artigo em Espanhol | BINACIS | ID: bin-129586

RESUMO

La hiperglucemia con o sin diabetes preexistente es un hallazgo frecuente en pacientes que cursan un síndrome coronario agudo. Estudios previos han demostrado que la hiperglucemia es altamente prevalente y se asocia a un mayor riesgo de muerte y complicaciones hospitalarias. Los mecanismos fisiopatológicos mediante los cuales la hiperglucemia provoca resultados adversos no son claros, y se desconoce si es un marcador de eventos o su causa. Los efectos perjudiciales de la hiperglucemia en el sistema cardiovascular son múltiples, y el control de los niveles de glucosa con insulina parece mejorar el pronóstico en estos pacientes. Se han desarrollado numerosos protocolos para el control de glucemia que demostraron ser seguros y efectivos. En una iniciativa originada en el Consejo de Emergencias de la Sociedad Argentina de Cardiología, se convocó a expertos de nuestro medio con el propósito de debatir estrategias para el control de la glucemia en pacientes que cursan un síndrome coronario agudo. Este documento refleja lo discutido en este evento académico con la intención de resumir los principales aspectos del control de la glucemia y ofrecer recomendaciones generales de tratamiento en la Unidad Coronaria.(AU)


Hyperglycemia with or without pre-existing diabetes mellitus, occurs frequently in the setting of acute coronary syndrome. Previous studies have demonstrated that hyperglycemia is highly prevalent and is associated with an increased risk of hospital complications and death. The underlying pathophysiology related an adverse clinical outcome to hyperglycemia is unclear, and it is uncertain whether increased serum glucose is simply a marker of adverse outcomes or their cause. Detrimental effects of hyperglycemia on the cardiovascular system are multiple. Glycemia control with insulin would prevent adverse outcomes. Numerous glucose-control protocols have been developed and tested proving to be safe and effective. In an initiative from the Emergency Council of the Argentine Society of Cardiology, local experts analyzed the management of hyperglycemia in acute coronary syndrome. The main objective of the prevent statement is to summarize the current state of knowledge on glycemic control, and to offer general recommendations regarding glucose management in the coronary care unit.(AU)

19.
Medicina (B.Aires) ; 72(2): 135-142, abr. 2012. tab
Artigo em Espanhol | BINACIS | ID: bin-127762

RESUMO

La hiperglucemia con o sin diabetes preexistente es un hallazgo frecuente en pacientes que cursan un síndrome coronario agudo. Estudios previos han demostrado que la hiperglucemia es altamente prevalente y se asocia a un mayor riesgo de muerte y complicaciones hospitalarias. Los mecanismos fisiopatológicos mediante los cuales la hiperglucemia provoca resultados adversos no son claros, y se desconoce si es un marcador de eventos o su causa. Los efectos perjudiciales de la hiperglucemia en el sistema cardiovascular son múltiples, y el control de los niveles de glucosa con insulina parece mejorar el pronóstico en estos pacientes. Se han desarrollado numerosos protocolos para el control de glucemia que demostraron ser seguros y efectivos. En una iniciativa originada en el Consejo de Emergencias de la Sociedad Argentina de Cardiología, se convocó a expertos de nuestro medio con el propósito de debatir estrategias para el control de la glucemia en pacientes que cursan un síndrome coronario agudo. Este documento refleja lo discutido en este evento académico con la intención de resumir los principales aspectos del control de la glucemia y ofrecer recomendaciones generales de tratamiento en la Unidad Coronaria.(AU)


Hyperglycemia with or without pre-existing diabetes mellitus, occurs frequently in the setting of acute coronary syndrome. Previous studies have demonstrated that hyperglycemia is highly prevalent and is associated with an increased risk of hospital complications and death. The underlying pathophysiology related an adverse clinical outcome to hyperglycemia is unclear, and it is uncertain whether increased serum glucose is simply a marker of adverse outcomes or their cause. Detrimental effects of hyperglycemia on the cardiovascular system are multiple. Glycemia control with insulin would prevent adverse outcomes. Numerous glucose-control protocols have been developed and tested proving to be safe and effective. In an initiative from the Emergency Council of the Argentine Society of Cardiology, local experts analyzed the management of hyperglycemia in acute coronary syndrome. The main objective of the prevent statement is to summarize the current state of knowledge on glycemic control, and to offer general recommendations regarding glucose management in the coronary care unit.(AU)

20.
Respir Care ; 57(3): 363-9, 2012 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-21968296

RESUMO

BACKGROUND: The application of CPAP has been used to minimize postoperative pulmonary complications after lung resection surgery. The aim of this study was to quantify both the CPAP effects upon lung function and functional capacity in early postoperative lung resection, as well as to evaluate if CPAP prolongs air leak through the chest drain. METHODS: Thirty patients in the postoperative period of lung resection were allocated into 2 groups: an experimental group, consisting of 15 patients who underwent a 10 cm H(2)O CPAP, and a 15 patient control group, who performed breathing exercises. Arterial blood gas analysis, peak expiratory flow (PEF), respiratory muscle strength, spirometry, and 6-min walk test (6MWT) were assessed in the preoperative period, and repeated postoperatively on the first and on the seventh day (6MWT was repeated only on the seventh day). RESULTS: Significant increases in PEF, muscle strength, and FEV(1) between the first and seventh postoperative day were observed, both in the experimental and in the control group, whereas FVC and P(aO(2)) increased significantly between the first and seventh postoperative day only in the experimental group. The average loss in 6-min walk distance (6MWD) from preoperative to postoperative day 7 in the experimental group was significantly lower than in control group. When comparing the 2 groups, only 6MWD was statistically different (P < .001). There was no air leakage increase through the drain with the early use of CPAP. CONCLUSION: When compared to breathing exercises, CPAP increases the 6MWD in postoperative lung resection patients, without prolonging air leak through the chest drain.


Assuntos
Pressão Positiva Contínua nas Vias Aéreas , Teste de Esforço , Pneumonectomia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Pneumopatias/fisiopatologia , Pneumopatias/cirurgia , Masculino , Pessoa de Meia-Idade , Pneumonectomia/reabilitação , Período Pós-Operatório , Recuperação de Função Fisiológica , Testes de Função Respiratória , Adulto Jovem
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