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1.
Int J Stroke ; : 1747493019895654, 2020 Jan 19.
Artigo em Inglês | MEDLINE | ID: mdl-31955706

RESUMO

BACKGROUND: Idarucizumab is a monoclonal antibody fragment with high affinity for dabigatran reversing its anticoagulant effects within minutes. Thereby, patients with acute ischemic stroke who are on dabigatran treatment may become eligible for thrombolysis with recombinant tissue-type plasminogen activator (rt-PA). In patients on dabigatran with intracerebral hemorrhage idarucizumab could prevent lesion growth. AIMS: To provide insights into the clinical use of idarucizumab in patients under effective dabigatran anticoagulation presenting with signs of acute ischemic stroke or intracranial hemorrhage. METHODS: Retrospective data collected from German neurological/neurosurgical departments administering idarucizumab following product launch from January 2016 to August 2018 were used. RESULTS: One-hundred and twenty stroke patients received idarucizumab in 61 stroke centers. Eighty patients treated with dabigatran presented with ischemic stroke and 40 patients suffered intracranial bleeding (intracerebral hemorrhage (ICH) in n = 27). In patients receiving intravenous thrombolysis with rt-PA following idarucizumab, 78% showed a median improvement of 7 points in National Institutes of Health Stroke Scale. No bleeding complications were reported. Hematoma growth was observed in 3 out of 27 patients with ICH. Outcome was favorable with a median National Institutes of Health Stroke Scale improvement of 4 points and modified Rankin score 0-3 in 61%. Six out of 40 individuals (15%) with intracranial bleeding died during hospital stay. CONCLUSION: Administration of rt-PA after reversal of dabigatran activity with idarucizumab in case of acute ischemic stroke seems feasible, effective, and safe. In dabigatran-associated intracranial hemorrhage, idarucizumab appears to prevent hematoma growth and to improve outcome.

2.
Neuroradiol J ; 32(4): 277-286, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31104586

RESUMO

PURPOSE: This study compares computed tomography angiography-based collateral scoring systems in regard to their inter-rater reliability and potential to predict functional outcome after endovascular thrombectomy, and relates them to parenchymal perfusion as measured by computed tomography perfusion. METHODS: Eighty-four patients undergoing endovascular thrombectomy in anterior circulation ischaemic stroke were enrolled. Modified Tan Score, Miteff Score, Maas Score and Opercular Index Score ratio were assessed in pre-interventional computed tomography angiographies independently by two readers. Collateral scores were tested for inter-rater reliability by weighted-kappa, for correlations with three-months modified Rankin Scale, and their potential to differentiate between patients with favourable (modified Rankin Scale ≤2) and poor outcome (modified Rankin Scale ≥3). Correlations with relative cerebral blood volume and relative cerebral blood flow were tested in patients with available computed tomography perfusion. RESULTS: Very good inter-rater reliability was found for Modified Tan, Miteff and Opercular Index Score ratio, and substantial reliability for Maas. There were no significant correlations between collateral scores and three-months modified Rankin Scale, but significant group differences between patients with favourable and poor outcome for Maas, Miteff and Opercular Index Score ratio. Miteff and Maas were significant predictors of favourable outcome in binary logistic regression analysis. Miteff best differentiated between both outcome groups in receiver-operating characteristics, and Maas reached highest sensitivity for favourable outcome prediction of 96%. All collateral scores significantly correlated with mean relative cerebral blood volume and relative cerebral blood flow. CONCLUSIONS: Computed tomography angiography scores are valuable in estimating functional outcome after mechanical thrombectomy and reliable across readers. The more complex scores, Maas and Miteff, show the best performances in predicting favourable outcome.


Assuntos
Isquemia Encefálica/terapia , Trombólise Mecânica/métodos , Acidente Vascular Cerebral/terapia , Adulto , Idoso , Idoso de 80 Anos ou mais , Isquemia Encefálica/diagnóstico por imagem , Isquemia Encefálica/fisiopatologia , Angiografia Cerebral/métodos , Circulação Colateral/fisiologia , Angiografia por Tomografia Computadorizada/métodos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Acidente Vascular Cerebral/diagnóstico por imagem , Acidente Vascular Cerebral/fisiopatologia , Resultado do Tratamento
3.
Fortschr Neurol Psychiatr ; 87(4): 225-233, 2019 Apr.
Artigo em Alemão | MEDLINE | ID: mdl-30999379

RESUMO

Die S1-Leitlinie "Diagnostik und Therapie der erektilen Dysfunktion" (AWMF-Registernummer 030 / 112) steht in einer vollständig überarbeiteten Neufassung zur Verfügung. Erektile Dysfunktion ist definiert als die fortwährende Unfähigkeit, eine penile Erektion, die für einen befriedigenden Geschlechtsverkehr ausreicht, zu erreichen oder aufrechtzuerhalten. Betroffen sind Millionen Bundesbürger: Bei Männern mit regelmäßiger sexueller Aktivität nimmt die erektile Dysfunktion von 2,3 Prozent in der dritten Lebensdekade auf 53,4 Prozent in der siebten Lebensdekade zu. Die Leitlinie gibt dezidierte Empfehlungen zur adäquaten Diagnose und zur Therapie der erektilen Dysfunktion, die seit der Einführung der Phosphodiesterase-5-(PDE-5-)Hemmer häufig unkritisch erfolgt.


Assuntos
Disfunção Erétil/diagnóstico , Disfunção Erétil/terapia , Humanos , Masculino , Guias de Prática Clínica como Assunto
4.
Front Neurol ; 5: 118, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-25071706

RESUMO

Many patients with postural tachycardia syndrome (PoTS) suffer from fatigue, daytime sleepiness, and sleeping disturbances. The objective of this study was to compare subjective and objective sleep quality of PoTS patients with a group of healthy controls. All patients completed a Pittsburgh Sleep Quality Index questionnaire and the Epworth Sleepiness Scale. The patients sleep architecture, heart rate, and heart rate variability (HRV) measurements were taken during one night at the sleep laboratorium. All data was collected at the Sleep Unit, at Helios Klinikum Wuppertal. Thirty-eight patients diagnosed with PoTS were compared to 31 healthy controls, matched in age and gender. Patients with PoTS reached significantly higher scores in sleep questionnaires, which means that they were more sleepy and had a lower sleep quality. Polysomnography showed a significantly higher proportion of stage 2 sleep. The results of HRV analysis in different sleep stages confirmed changes in autonomic activity in both groups. PoTS patients, however, showed a diminished variability of the low-frequency (LF) band, high-frequency (HF) band, and LF/HF ratio in different sleep stages. It can therefore be gathered that PoTS could be considered as potential differential diagnosis for sleep disturbances since PoTS patients had a subjective diminished sleep quality, reached higher levels of daytime sleepiness, and showed a higher proportion of stage 2 sleep. PoTS patients showed furthermore a reduction of LF/HF ratio variability in different sleep stages.

5.
Muscle Nerve ; 50(6): 956-61, 2014 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-24647968

RESUMO

INTRODUCTION: Postural tachycardia syndrome (POTS) is a disorder of orthostatic intolerance characterized by excessive tachycardia of unknown etiology. Our objective in this study was to evaluate the correlation between C-fiber involvement as shown by skin biopsy and adrenergic cardiac metaiodobenzylguanadine (MIBG) uptake in POTS patients. METHODS: Skin biopsies of 84 patients with POTS were examined by Protein Gene Product 9.5 (PGP9.5) immunohistochemistry and were compared with MIBG myocardial scintigraphy imaging data. RESULTS: Mean intraepidermal nerve fiber (IENF) density was in the lower normal age-adjusted range, 7.2 ± 2.9/mm (normal ≥ 7/mm), and was slightly below the normal range in 45% of POTS patients. MIBG uptake was reduced in 21% of patients. Low IENF density correlated with reduced cardiac MIBG uptake (r = 0.39, P = 0.001). CONCLUSIONS: A subset of neuropathic POTS patients may harbor mild small fiber neuropathy with abnormalities of unmyelinated nerve fibers in the skin associated with reduced myocardial postganglionic sympathetic innervation.


Assuntos
Eritromelalgia/diagnóstico , Eritromelalgia/patologia , Coração/inervação , Degeneração Neural/diagnóstico , Degeneração Neural/patologia , Síndrome da Taquicardia Postural Ortostática/complicações , 3-Iodobenzilguanidina/metabolismo , Adolescente , Adulto , Biópsia , Estudos de Coortes , Comorbidade , Eritromelalgia/epidemiologia , Feminino , Coração/diagnóstico por imagem , Humanos , Incidência , Masculino , Miocárdio/metabolismo , Miocárdio/patologia , Degeneração Neural/epidemiologia , Fibras Nervosas Amielínicas/patologia , Síndrome da Taquicardia Postural Ortostática/patologia , Estudos Retrospectivos , Pele/inervação , Pele/patologia , Tomografia Computadorizada de Emissão de Fóton Único , Adulto Jovem
6.
Front Neurol ; 4: 49, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-23720648

RESUMO

Non-motor symptoms are now commonly recognized in Parkinson's disease (PD) and can include dysautonomia. Impairment of cardiovascular autonomic function can occur at any stage of PD but is typically prevalent in advanced stages or related to (anti-Parkinsonian) drugs and can result in atypical blood pressure (BP) readings and related symptoms such as orthostatic hypotension (OH) and supine hypertension. OH is usually diagnosed with a head-up-tilt test (HUT) or an (active) standing test (also known as Schellong test) in the laboratory, but 24 h ambulatory blood pressure monitoring (ABPM) in a home setting may have several advantages, such as providing an overview of symptoms in daily life alongside pathophysiology as well as assessment of treatment interventions. This, however, is only possible if ABPM is administrated correctly and an autonomic protocol (including a diary) is followed which will be discussed in this review. A 24-h ABPM does not only allow the detection of OH, if it is present, but also the assessment of cardiovascular autonomic dysfunction during and after various daily stimuli, such as postprandial and alcohol dependent hypotension, as well as exercise and drug induced hypotension. Furthermore, information about the circadian rhythm of BP and heart rate (HR) can be obtained and establish whether or not a patient has a fall of BP at night (i.e., "dipper" vs. non-"dipper"). The information about nocturnal BP may also allow the investigation or detection of disorders such as sleep dysfunction, nocturnal movement disorders, and obstructive sleep apnea, which are common in PD. Additionally, a 24-h ABPM should be conducted to examine the effectiveness of OH therapy. This review will outline the methodology of 24 h ABPM in PD, summarize findings of such studies in PD, and briefly consider common daily stimuli that might affect 24 h ABPM.

8.
Clin Auton Res ; 21(2): 125-6, 2011 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-21125412

RESUMO

Clinicians should consider impaired gastric emptying when evaluating patients with myotonic dystrophy type 1 and severe symptoms of upper gut dysmotility. Gastric emptying time measurement by radionuclide study, although informative, is rarely done in clinical practice.


Assuntos
Gastroparesia/diagnóstico por imagem , Gastroparesia/etiologia , Distrofia Miotônica/complicações , Distrofia Miotônica/diagnóstico por imagem , Adulto , Feminino , Humanos , Cintilografia
9.
J Neurol Neurosurg Psychiatry ; 81(3): 339-43, 2010 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-19687022

RESUMO

BACKGROUND: Postural orthostatic tachycardia syndrome (POTS) is a disorder of orthostatic intolerance characterised by excessive tachycardia of unknown aetiology. Whether this condition involves abnormal cardiac sympathetic innervation or function remains elusive. Meta-iodobenzylguanidine (MIBG) resembles guanethidine and is a pharmacologically inactive analogue of norepinephrine, which is similarly metabolised in noradrenergic neurons. MIBG myocardial scintigraphy is used clinically to estimate local myocardial sympathetic nerve damage in some forms of heart disease and autonomic neuropathy. The objective of this study was to evaluate cardiac sympathetic innervation in patients with POTS. METHODS: 20 patients with POTS were studied using (123)I-MIBG-single photon emission computed tomography, standardised autonomic testing, assessment of catecholamine plasma levels and sympathetic skin response. RESULTS: In four POTS patients (20.0%), myocardial MIBG uptake was markedly decreased. The mean heart to mediastinum ratio was reduced to 1.22+/-0.08 compared with the normal range of >1.7. No correlation was found between myocardial MIBG uptake and degree of postural tachycardia, baroreflex sensitivity, catecholamine plasma levels or other autonomic parameters. Sympathetic skin responses were normal in all patients. CONCLUSIONS: These findings suggest that POTS may be, in part, a manifestation of autonomic cardiac neuropathy. MIBG myocardial scintigraphy may be helpful to distinguish patients with neuropathic POTS from patients with orthostatic intolerance of other origin.


Assuntos
3-Iodobenzilguanidina , Doenças do Sistema Nervoso Autônomo/fisiopatologia , Coração/inervação , Síndrome da Taquicardia Postural Ortostática/diagnóstico por imagem , Síndrome da Taquicardia Postural Ortostática/fisiopatologia , Compostos Radiofarmacêuticos , Sistema Nervoso Simpático/fisiopatologia , Tomografia Computadorizada de Emissão de Fóton Único , Adulto , Doenças do Sistema Nervoso Autônomo/diagnóstico por imagem , Pressão Sanguínea/fisiologia , Diagnóstico Diferencial , Eletrocardiografia , Feminino , Análise de Fourier , Resposta Galvânica da Pele/fisiologia , Frequência Cardíaca/fisiologia , Humanos , Masculino , Norepinefrina/sangue , Valores de Referência , Processamento de Sinais Assistido por Computador
10.
J Med Case Rep ; 2: 239, 2008 Jul 24.
Artigo em Inglês | MEDLINE | ID: mdl-18652657

RESUMO

INTRODUCTION: Diagnosis of Takayasu's arteritis as the cause of stroke is often delayed because of non-specific clinical presentation. F-18-fluorodeoxyglucose positron emission tomography-computed tomography may help to accurately diagnose and monitor Takayasu's arteritis in stroke patients. CASE PRESENTATION: We report the case of a left middle cerebral artery stroke in a 39-year-old man. Laboratory data were consistent with an inflammatory reaction. While abdominal contrast-enhanced computed tomography showed an aneurysm of the infrarenal aorta, only F-18-fluorodeoxyglucose positron emission tomography-computed tomography revealed pathology (that is, intense F-18-fluorodeoxyglucose accumulation) in the carotid arteries, ascending aorta and the abdominal aorta cranial to the aneurysm. After treatment with high-dose prednisone followed by cyclophosphamide, the signs of systemic inflammation decreased and F-18-fluorodeoxyglucose uptake was reduced as compared with the initial scan. CONCLUSION: F-18-fluorodeoxyglucose positron emission tomography-computed tomography showed inflammatory activity in the aorta and carotid arteries, suggestive of Takayasu's arteritis in a young stroke patient, and follow-up under immunosuppressive therapy indicated reduced F-18-fluorodeoxyglucose uptake. F-18-fluorodeoxyglucose positron emission tomography-computed tomography appears to be useful in detecting and quantifying the extent of vascular wall activity in systemic large-vessel vasculitis.

11.
Clin Auton Res ; 18(1): 40-2, 2008 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-17898925

RESUMO

Myocardial 123I-Meta-iodobenzylguanidine uptake was markedly reduced in a patient with postural tachycardia syndrome (POTS). This finding suggests that loss of sympathetic autonomic neurons in the heart may play a role in the etiology of POTS.


Assuntos
Doenças do Sistema Nervoso Autônomo/complicações , Coração/inervação , Postura , Taquicardia/etiologia , Adulto , Doenças do Sistema Nervoso Autônomo/diagnóstico , Doenças do Sistema Nervoso Autônomo/fisiopatologia , Feminino , Coração/efeitos dos fármacos , Humanos , Síndrome , Taquicardia/complicações
12.
Seizure ; 15(6): 443-8, 2006 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-16787750

RESUMO

Valproic acid (VPA) is a broad-spectrum antiepileptic drug and is usually well-tolerated. Rare serious complications may occur in some patients, including haemorrhagic pancreatitis, bone marrow suppression, VPA-induced hepatotoxicity and VPA-induced encephalopathy. The typical signs of VPA-induced encephalopathy are impaired consciousness, sometimes marked EEG background slowing, increased seizure frequency, with or without hyperammonemia. There is still no proof of causative effect of VPA in patients with encephalopathy, but only of an association with an assumed causal relation. We report 19 patients with VPA-associated encephalopathy in Germany from the years 1994 to 2003, none of whom had been published previously.


Assuntos
Anticonvulsivantes/efeitos adversos , Encefalopatias/induzido quimicamente , Hiperamonemia/induzido quimicamente , Síndromes Neurotóxicas/etiologia , Ácido Valproico/efeitos adversos , Adolescente , Idoso , Pré-Escolar , Feminino , Humanos , Lactente , Masculino , Pessoa de Meia-Idade , Inquéritos e Questionários
13.
J Neurol ; 253 Suppl 1: I21-5, 2006 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-16477481

RESUMO

Symptoms related to alterations of the autonomic nervous system are frequent in patients with multiple sclerosis (MS). Bladder or bowel dysfunction or impairment of sexual performance is highly distressing for most MS patients,whereas the clinical relevance of other autonomic symptoms is less clear. Cardiovascular autonomic alterations might relate to clinical signs such as orthostatic intolerance; a relationship with fatigue is uncertain. However, the frequency of abnormal findings in tests for the cardiovascular autonomic system varies due to the lack of standardized test performance or differentially used cut-off values. The incidence of additional symptoms such as pupillomotor or sweating alterations and especially their relationship to overall autonomic nervous system abnormalities is not well known. Although their impact on daily life is low, they can at least serve as diagnostic tools. Beside these clinical aspects, alterations of the autonomic nervous system have also been reported to alter immunological cascades in experimental conditions. However, corresponding results have not been confirmed in clinical trials yet.


Assuntos
Doenças do Sistema Nervoso Autônomo/etiologia , Doenças do Sistema Nervoso Autônomo/fisiopatologia , Sistema Nervoso Autônomo/fisiopatologia , Esclerose Múltipla/complicações , Esclerose Múltipla/fisiopatologia , Regulação da Temperatura Corporal/fisiologia , Doenças Cardiovasculares/etiologia , Doenças Cardiovasculares/fisiopatologia , Humanos , Pupila/fisiologia , Sudorese/fisiologia , Doenças da Bexiga Urinária/etiologia , Doenças da Bexiga Urinária/fisiopatologia
14.
J Neurol ; 253 Suppl 1: I3-9, 2006 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-16477484

RESUMO

Multiple sclerosis (MS) is the most frequent chronic neurological disease affecting young persons in developed countries. MS is, however, considered as a secondary cause, of central origin, for autonomic dysfunction. The most common autonomic symptoms in MS are disorders of micturation, impotence, sudomotor and gastrointestinal disturbances, orthostatic intolerance as well as sleep disorders. The majority of the patients suffer at some period of the disease from lower urinary tract symptoms and sexual dysfunction. Awareness and treatment of these conditions is vital to improving health and quality of life in patients with MS. The increased understanding of the pathophysiological mechanisms in autonomic dysfunction in MS, along with technological and pharmaceutical developments has advanced our ability to treat the multiple aspects complicating autonomic failure in MS.


Assuntos
Doenças do Sistema Nervoso Autônomo/etiologia , Esclerose Múltipla/complicações , Disreflexia Autonômica/etiologia , Disreflexia Autonômica/fisiopatologia , Doenças do Sistema Nervoso Autônomo/fisiopatologia , Doenças Cardiovasculares/etiologia , Doenças Cardiovasculares/fisiopatologia , Gastroenteropatias/etiologia , Gastroenteropatias/fisiopatologia , Humanos , Hipotensão Ortostática/etiologia , Hipotensão Ortostática/fisiopatologia , Esclerose Múltipla/fisiopatologia , Disfunções Sexuais Psicogênicas/etiologia , Disfunções Sexuais Psicogênicas/fisiopatologia , Transtornos do Sono-Vigília/etiologia , Transtornos do Sono-Vigília/fisiopatologia , Doenças das Glândulas Sudoríparas/etiologia , Doenças das Glândulas Sudoríparas/fisiopatologia , Doenças da Bexiga Urinária/etiologia , Doenças da Bexiga Urinária/fisiopatologia
15.
Epilepsia ; 47(12): 2027-31, 2006 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-17201699

RESUMO

PURPOSE: Valproic acid (VPA) is an antiepileptic drug (AED) commonly used for generalized and focal epilepsies. We provide an update on hepatotoxic side effects in Germany between 1994 and 2003. METHODS: We mailed a questionnaire to all members of the German Section of the International League Against Epilepsy, asking for VPA-induced side effects, especially severe side effects such as hepatopathy. RESULTS: As a result of our questionnaire, we found 31 cases of reversible hepatotoxicity and nine cases of lethal hepatopathies in Germany from 1994 to 2003. CONCLUSIONS: The outcome of patients with severe hepatotoxicity is better than that in the past. The risk of a VPA-induced hepatopathy is not limited to patients younger than 2 years, receiving polytherapy, or patients with congenital or acquired metabolic diseases.


Assuntos
Anticonvulsivantes/efeitos adversos , Doença Hepática Induzida por Substâncias e Drogas , Doença Hepática Induzida por Substâncias e Drogas/etiologia , Epilepsia/tratamento farmacológico , Ácido Valproico/efeitos adversos , Adolescente , Adulto , Fatores Etários , Anticonvulsivantes/uso terapêutico , Doença Hepática Induzida por Substâncias e Drogas/epidemiologia , Doença Hepática Induzida por Substâncias e Drogas/mortalidade , Criança , Pré-Escolar , Comorbidade , Quimioterapia Combinada , Epilepsia/epidemiologia , Evolução Fatal , Feminino , Alemanha/epidemiologia , Humanos , Lactente , Hepatopatias/epidemiologia , Hepatopatias/mortalidade , Falência Hepática/induzido quimicamente , Falência Hepática/epidemiologia , Falência Hepática/mortalidade , Masculino , Doenças Metabólicas/epidemiologia , Fatores de Risco , Inquéritos e Questionários , Ácido Valproico/uso terapêutico
16.
Mov Disord ; 21(4): 486-91, 2006 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-16258941

RESUMO

Extrasystoles occur in normal subjects but are significant more frequently (16.25% vs. 55%; chi(2) = 19.3; P < 0.001) seen in Parkinson's disease (PD) patients. The extrasystolic decreases in stroke volume and systolic pressure activate sympathetic vasomotor innervation and lead to a blood pressure increase for a few heartbeats. The purpose of this study was to prove whether the short time analysis of this blood pressure regulation allows the assessment of sympathetic neurocirculatory function. Records of noninvasive blood pressure monitoring were reviewed from 40 PD patients and 80 controls. A battery of cardiovascular autonomic tests, including Valsalva maneuver, tilt-table testing, echocardiography, and cardiac scintigraphy with [(123)I]meta-iodobenzylguanidine were performed. Fifty-five percent of the PD patients had at least one premature ventricular contraction (PVC) in 10 minutes lying supine at rest. After every PVC (13 PVCs) recorded from normal subjects, we found an increase in systolic blood pressure above base line with a maximum at the seventh heart beat. In all of the 22 PD patients, the systolic blood pressure was significantly decreased less than baseline in every PVC from the second to the ninth postextrasystolic beat (P < 0.001). In both groups, the extrasystolic fall in blood pressure was on average approximately 22%. The postextrasystolic potentiation did not differ (5.3% vs. 4.4%, not significant). If a PVC occurs, the analysis of short-time blood pressure regulation is a sensitive tool for baroreceptor reflex function. The advantage of this method results from the independence of patients cooperation and the high sensitivity to prove a sympathetic neurocirculatory failure within 10 heart beats.


Assuntos
Pressão Sanguínea/fisiologia , Doença de Parkinson/fisiopatologia , Pressorreceptores/fisiologia , Complexos Ventriculares Prematuros/fisiopatologia , 3-Iodobenzilguanidina/farmacocinética , Adulto , Idoso , Idoso de 80 Anos ou mais , Monitorização Ambulatorial da Pressão Arterial/métodos , Estudos de Casos e Controles , Distribuição de Qui-Quadrado , Eletrocardiografia/métodos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Doença de Parkinson/complicações , Compostos Radiofarmacêuticos/farmacocinética , Fluxo Sanguíneo Regional/fisiologia , Teste da Mesa Inclinada/métodos , Complexos Ventriculares Prematuros/complicações
17.
Clin Auton Res ; 13(6): 450-2, 2003 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-14673697

RESUMO

The relationship of disturbed autonomic skin innervation to altered transdermal absorption in polyneuropathy is not yet clear. In this study we measured serum estradiol in 29 normals and 10 polyneuropathy patients to assess potential differences of estradiol uptake from different skin sites.


Assuntos
Estradiol/farmacocinética , Doenças do Sistema Nervoso Periférico/metabolismo , Absorção , Administração Cutânea , Adulto , Idoso , Estudos de Casos e Controles , Estudos Cross-Over , Estradiol/administração & dosagem , Estradiol/sangue , Feminino , , Humanos , Masculino , Pessoa de Meia-Idade , Doenças do Sistema Nervoso Periférico/sangue , Ombro
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