Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 101
Filtrar
1.
Med Sci Monit ; 27: e928937, 2021 Feb 03.
Artigo em Inglês | MEDLINE | ID: mdl-33534782

RESUMO

BACKGROUND Serum uric acid (UA) is involved in the development of hypertension. However, its impact on mortality in hypertension remains unclear. We aimed to assess the association of cardiovascular and all-cause mortality with UA in a hypertensive population. MATERIAL AND METHODS This study included 15 583 hypertensive patients from the NHANES study during 1999-2014. Weighted Cox regression analyses and cubic spline fitting were used to assess the relationship between UA and mortality risk. RESULTS Over a median follow-up of 7.4 years (116 351 person-years), a total of 3291 deaths occurred. Mortality was examined according to 5 predefined UA levels: £3.5, 3.5-5, 5-6, 6-7.5, and >7.5 mg/dL. In multivariable analysis with 5-6 mg/dL as a reference, the hazard ratios (95% confidence interval) of total mortality across the 5 groups were 1.40 (1.05-1.88), 1.08 (0.95-1.21), 1.00 (reference), 1.14 (1.02-1.29), and 1.74 (1.50-2.02), respectively. According to a restricted cubic spline, we noted a U-shaped relationship between UA and total mortality. The U-shaped relationship between UA and cardiovascular mortality remained in both females and males. The increased cardiovascular mortality in the lowest and highest UA groups was attributed to stroke and heart-specific mortality, respectively. However, serum UA was not significantly associated with cancer mortality. CONCLUSIONS Our findings showed a U-shaped relationship between serum UA levels and total and cardiovascular mortality in patients with hypertension. Furthermore, low UA was associated with stroke mortality, while higher UA was associated with heart-related mortality. Further research is needed to identify the potential mechanisms of UA in hypertension.

2.
Sensors (Basel) ; 21(1)2021 Jan 02.
Artigo em Inglês | MEDLINE | ID: mdl-33401737

RESUMO

Pollutant gases, such as CO, NO2, O3, and SO2 affect human health, and low-cost sensors are an important complement to regulatory-grade instruments in pollutant monitoring. Previous studies focused on one or several species, while comprehensive assessments of multiple sensors remain limited. We conducted a 12-month field evaluation of four Alphasense sensors in Beijing and used single linear regression (SLR), multiple linear regression (MLR), random forest regressor (RFR), and neural network (long short-term memory (LSTM)) methods to calibrate and validate the measurements with nearby reference measurements from national monitoring stations. For performances, CO > O3 > NO2 > SO2 for the coefficient of determination (R2) and root mean square error (RMSE). The MLR did not increase the R2 after considering the temperature and relative humidity influences compared with the SLR (with R2 remaining at approximately 0.6 for O3 and 0.4 for NO2). However, the RFR and LSTM models significantly increased the O3, NO2, and SO2 performances, with the R2 increasing from 0.3-0.5 to >0.7 for O3 and NO2, and the RMSE decreasing from 20.4 to 13.2 ppb for NO2. For the SLR, there were relatively larger biases, while the LSTMs maintained a close mean relative bias of approximately zero (e.g., <5% for O3 and NO2), indicating that these sensors combined with the LSTMs are suitable for hot spot detection. We highlight that the performance of LSTM is better than that of random forest and linear methods. This study assessed four electrochemical air quality sensors and different calibration models, and the methodology and results can benefit assessments of other low-cost sensors.

3.
Artigo em Inglês | MEDLINE | ID: mdl-33389011

RESUMO

OBJECTIVE: Functional magnetic resonance imaging (fMRI) allows the measurement of changes in blood flow in association with changes in brain activity. This technique has been used frequently to study brain activation in response to odorous stimuli. The aim of this study was to evaluate the effects of odor delivery conditions on brain responses obtained with fMRI. STUDY DESIGN: Prospective cohort study SETTING: Academic institution. METHODS: Twenty healthy volunteers (mean age = 29.5 years; 9 women, 11 men) participated. Three odor delivery methods were used: "tube" (odor presented intranasally with separate tubing for each nostril), "mask" (odor presented in a face mask covering the subject's nose) and "vacuum" (odor presented into the ambient air). Presentation of the pleasant "peach" odor was performed using a computer-controlled olfactometer. Subjects were asked to evaluate the intensity of the odors after each fMRI run. RESULTS: "Tube" showed higher self-rated odor intensity compared to "mask" and "vacuum" (F = 18.4, p < 0.001). Odor intensity had a positive correlation (r = 0.6, p < 0.05) with percent signal change extracted from the secondary olfactory cortex region in the mask condition. In the tube condition, several selected regions of interest (Amygdala, Insula, Thalamus) showed lower activations compared to the other two conditions (puncorrected < 0.001, mask > tube, vacuum > tube). CONCLUSION: Activations of region of interests (ROIs) in response to the odorous stimuli showed differences under the three conditions (mask, tube, vacuum). In this passive fMRI paradigm, this may partly reflect the differences in odor intensity, but also in attention and contextual variables related to odor perception.

4.
Sci Total Environ ; 750: 141688, 2021 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-32835964

RESUMO

The outbreak of coronavirus disease 2019 (COVID-19) has caused tremendous loss to human life and economic decline in China and worldwide. It has significantly reduced gross domestic product (GDP), power generation, industrial activity and transport volume; thus, it has reduced fossil-related and cement-induced carbon dioxide (CO2) emissions in China. Due to time delays in obtaining activity data, traditional emissions inventories generally involve a 2-3-year lag. However, a timely assessment of COVID-19's impact on provincial CO2 emission reductions is crucial for accurately understanding the reduction and its implications for mitigation measures; furthermore, this information can provide constraints for modeling studies. Here, we used national and provincial GDP data and the China Emission Accounts and Datasets (CEADs) inventory to estimate the emission reductions in the first quarter (Q1) of 2020. We find a reduction of 257.7 Mt. CO2 (11.0%) over Q1 2019. The secondary industry contributed 186.8 Mt. CO2 (72.5%) to the total reduction, largely due to lower coal consumption and cement production. At the provincial level, Hubei contributed the most to the reductions (40.6 Mt) due to a notable decrease of 48.2% in the secondary industry. Moreover, transportation significantly contributed (65.1 Mt), with a change of -22.3% in freight transport and -59.1% in passenger transport compared with Q1 2019. We used a point, line and area sources (PLAS) method to test the GDP method, producing a close estimate (reduction of 10.6%). One policy implication is a change in people's working style and communication methods, realized by working from home and holding teleconferences, to reduce traffic emissions. Moreover, GDP is found to have potential merit in estimating emission changes when detailed energy activity data are unavailable. We provide provincial data that can serve as spatial disaggregation constraints for modeling studies and further support for both the carbon cycle community and policy makers.


Assuntos
Infecções por Coronavirus , Coronavirus , Pandemias , Pneumonia Viral , Betacoronavirus , Dióxido de Carbono/análise , China , Humanos
5.
Carbon Balance Manag ; 15(1): 25, 2020 Dec 03.
Artigo em Inglês | MEDLINE | ID: mdl-33269442

RESUMO

BACKGROUND: Quantifying CO2 emissions from cities is of great importance because cities contribute more than 70% of the global total CO2 emissions. As the largest urbanized megalopolis region in northern China, the Beijing-Tianjin-Hebei (Jing-Jin-Ji, JJJ) region (population: 112.7 million) is under considerable pressure to reduce carbon emissions. Despite the several emission inventories covering the JJJ region, a comprehensive evaluation of the CO2 emissions at the prefectural city scale in JJJ is still limited, and this information is crucial to implementing mitigation strategies. RESULTS: Here, we collected and analyzed 8 published emission inventories to assess the emissions and uncertainty at the JJJ city level. The results showed that a large discrepancy existed in the JJJ emissions among downscaled country-level emission inventories, with total emissions ranging from 657 to 1132 Mt CO2 (or 849 ± 214 for mean ± standard deviation (SD)) in 2012, while emission estimates based on provincial-level data estimated emissions to be 1038 and 1056 Mt. Compared to the mean emissions of city-data-based inventories (989 Mt), provincial-data-based inventories were 6% higher, and national-data-based inventories were 14% lower. Emissions from national-data-based inventories were 53-75% lower in the high-emitting industrial cities of Tangshan and Handan, while they were 47-160% higher in Beijing and Tianjin than those from city-data-based inventories. Spatially, the emissions pattern was consistent with the distribution of urban areas, and urban emissions in Beijing contributed 50-70% of the total emissions. Higher emissions from Beijing and Tianjin resulted in lower estimates of prefectural cities in Hebei for some national inventories. CONCLUSIONS: National-level data-based emission inventories produce large differences in JJJ prefectural city-level emission estimates. The city-level statistics data-based inventories produced more consistent estimates. The consistent spatial distribution patterns recognized by these inventories (such as high emissions in southern Beijing, central Tianjin and Tangshan) potentially indicate areas with robust emission estimates. This result could be useful in the efficient deployment of monitoring instruments, and if proven by such measurements, it will increase our confidence in inventories and provide support for policy makers trying to reduce emissions in key regions.

6.
Sci Rep ; 10(1): 18869, 2020 11 02.
Artigo em Inglês | MEDLINE | ID: mdl-33139777

RESUMO

Subjective hyperosmia refers to a self-reported olfactory ability that is superior to a normal, intact sense of smell (normosmia), and is associated with olfactory emotional experience. The current study used voxel-based morphometry to investigate the gray matter volume (GMV) in people with self-rated hyperosmia (subjective hyperosmia, SH, N = 18) in comparison to people with self-rated normal olfaction (subjective normosmia, SN, N = 14). Participants' olfactory function were assessed by the extensive olfactory test battery, the "Sniffin' Sticks" test. Within the predicted brain regions (regions-of-interest analyses), the SH participants showed larger GMV of the left hippocampus as compared to SN participants (FWE corrected p < 0.05). Further, the whole-brain search indicated that SH had larger GMV of the bilateral hippocampus, the right hypothalamus, the left precuneus, and the left superior frontal gyrus as compared to the SN group. ROI analyses showed positive correlations between the left hippocampal GMV and odor threshold or discrimination scores across all participants. In addition, the whole-brain analysis suggested that the self-rated olfactory ability was positively associated with GMV in the cerebellum, superior frontal gyrus and the precentral gyrus among SH participants. In conclusion, the current results suggest that SH was associated with increased GMV in several brain regions that were previously shown to be involved in the processing of cognitive aspects of odors.

7.
Front Hum Neurosci ; 14: 574148, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33132885

RESUMO

The understanding of food cue associated neural activations that predict future weight variability may guide the design of effective prevention programs and treatments for overeating and obesity. The current study investigated the association between brain response to different food odors with varied energy density and individual changes of body mass index (BMI) over 2 years. Twenty-five participants received high-fat (chocolate and peanut), low-fat (bread and peach) food odors, and a nonfood odor (rose) while the brain activation was measured using functional magnetic resonance imaging (fMRI). BMIs were calculated with participant's self-reported body weight and height collected at the time of the fMRI scan and again at 2 years later. Regression analyses revealed significant negative correlations between BMI increase over 2 years and brain activation of the bilateral precuneus and the right posterior cingulate cortex (PCC) in response to high-fat vs. low-fat food odors. Also, brain activation of the right supplementary motor area (SMA) in response to food vs. non-food odor was negatively correlated to subsequent BMI increase over 2 years. Taken together, the current findings suggest that individual differences in neural responsivity to (high calorie) food odors in brain regions of the default mode and motor control network serve as a neural marker for future BMI change.

8.
Carbohydr Polym ; 248: 116732, 2020 Nov 15.
Artigo em Inglês | MEDLINE | ID: mdl-32919549

RESUMO

Ion-imprinted thermosensitive chitosan derivative (ITC) was successfully synthesized through a novel gradient heating process towards applications in heavy metal remediation, using Cu2+ template paired with N-isopropylacrylamide (NIPAM) monomer. SEM, DSC, FTIR and Raman spectroscopy were used to characterize the structure and properties of ITC. The phase change temperature (PCT) of ITC was 35.31 °C in the heating cycle, whereas in the cooling cycle the PCT for ITC was 26.27 °C. The adsorption capacity of ITC for Cu2+ at 45 °C (> PCT) was 88.94 mg/g. Desorption rate of 98.90 % was achieved after washing with ultra-pure water at 20 °C (< PCT). An adsorption capacity of 85 mg/g and a desorption rate of 97 % sustained after five cycles reuse. The adsorption capacity for Cu2+ was measured at 80.23 mg/g under other seven interfering metal ions. The adsorption kinetics and adsorption isotherm fitted pseudo-second-order and Langmuir equation, respectively.

9.
Sci Rep ; 10(1): 14377, 2020 09 01.
Artigo em Inglês | MEDLINE | ID: mdl-32873836

RESUMO

Olfactory loss can be acquired (patients with a history of olfactory experiences), or inborn (patients without olfactory experiences/life-long inability to smell). Inborn olfactory loss, or congenital anosmia (CA), is relatively rare and there is a knowledge gap regarding the compensatory neural mechanisms involved in this condition. The study aimed to investigate the top-down olfactory processing in patients with CA or idiopathic acquired anosmia (IA) in comparison to normosmia controls (NC) during expectancy and reading of odor-associated words. Functional magnetic resonance imaging was used to assess brain activations in 14 patients with CA, 8 patients with IA, and 16 NC healthy participants during an expectancy and reading task. Words with strong olfactory associations (OW) (e.g. "banana") or with little or no olfactory associations (CW) (e.g. "chair") were used as stimuli and were presented with a block design Analyses were conducted to explore the brain activation in response to OW expectancy or OW reading between groups (CW as baseline). During the expectancy condition of OW, IA and NC groups showed stronger activation in posterior OFC extending to right insula, caudate region and frontal medial OFC respectively. Whereas during the reading condition of OW, CA patients showed stronger activation in posterior OFC extending to the insula. Increased activation of higher-order brain regions related to multisensory integration among CA patients suggests a compensatory mechanism for processing semantic olfactory cues.

10.
Artigo em Inglês | MEDLINE | ID: mdl-32803385

RESUMO

PURPOSE: The diagnosis of olfactory dysfunction is mainly based on psychophysical measurements. The aim of the current study was to investigate how well the olfactory functional magnetic resonance imaging (fMRI) can effectively distinguish between normosmic people and subjects with olfactory dysfunction. METHODS: Thirty-eight participants were recruited for the study. Group 1 consisted of 22 subjects with olfactory dysfunction (mean age = 44.3 years, SD = 18.6), and Group two consisted of 16 participants with normal olfactory function (mean age = 49.6 years, SD = 11.6). Olfactory functions were assessed in great detail for all participants, and brain activation in response to odorous stimulation was assessed using fMRI. RESULTS: The between-group comparison showed stronger odor induced brain activation of the primary olfactory area and the insular cortex among the normosmic group as compared to the dysosmic group. As indicated by the individual analysis, positive responses in the primary olfactory cortex were significantly higher in normosmic people (94%) than in subjects with olfactory dysfunction (41%). However, there was no association between individual fMRI parameters (including the percentage of BOLD signal change, activated cluster size and peak z value), and psychophysical olfactory test scores. Receiver operating characteristic analysis suggested the subjects could not be differentiated from normosmics based on their BOLD signal from the primary olfactory area, orbitofrontal cortex, or the insular cortex. CONCLUSION: There are large inter-individual variabilities for odor-induced brain activation among normosmic subjects and subjects with olfactory dysfunction, due to this variation, at present it appears problematic to diagnose olfactory dysfunction on an individual level using fMRI.

11.
Sensors (Basel) ; 20(16)2020 Aug 05.
Artigo em Inglês | MEDLINE | ID: mdl-32764476

RESUMO

Numerous particulate matter (PM) sensors with great development potential have emerged. However, whether the current sensors can be used for reliable long-term field monitoring is unclear. This study describes the research and application prospects of low-cost miniaturized sensors in PM2.5 monitoring. We evaluated five Plantower PMSA003 sensors deployed in Beijing, China, over 7 months (October 2019 to June 2020). The sensors tracked PM2.5 concentrations, which were compared to the measurements at the national control monitoring station of the Ministry of Ecology and Environment (MEE) at the same location. The correlations of the data from the PMSA003 sensors and MEE reference monitors (R2 = 0.83~0.90) and among the five sensors (R2 = 0.91~0.98) indicated a high accuracy and intersensor correlation. However, the sensors tended to underestimate high PM2.5 concentrations. The relative bias reached -24.82% when the PM2.5 concentration was >250 µg/m3. Conversely, overestimation and high errors were observed during periods of high relative humidity (RH > 60%). The relative bias reached 14.71% at RH > 75%. The PMSA003 sensors performed poorly during sand and dust storms, especially for the ambient PM10 concentration measurements. Overall, this study identified good correlations between PMSA003 sensors and reference monitors. Extreme field environments impact the data quality of low-cost sensors, and future corrections remain necessary.

12.
Scientometrics ; : 1-19, 2020 Jun 25.
Artigo em Inglês | MEDLINE | ID: mdl-32836525

RESUMO

Intriguing unforced regularities in human behaviors have been reported in varied research domains, including scientometrics. In this study we examine the manuscript submission behavior of researchers, with a focus on its monthly pattern. With a large and reliable dataset which records the submission history of articles published on 10 multidisciplinary journals and 10 management journals over a five-year period (2013-2017), we observe a prominent turn-of-the-month submission effect for accepted papers in management journals but not multidisciplinary journals. This effect gets more pronounced in submissions to top-tier journals and when the first day of a month happens to be a Saturday or Sunday. Sense of ceremony is proposed as a likely explanation of this effect, since the first day of a month is a fundamental temporal landmark which has a 'fresh start effect' on researchers. To conclude, an original and interesting day-of-the-month effect in the academia is reported in this study, which calls for more research attention.

13.
Mol Med Rep ; 22(3): 2404-2414, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32705199

RESUMO

Indian hedgehog signaling molecule (Ihh) is known to play critical roles in chondrogenesis and cartilage development. However, it remains largely unknown how Ihh is regulated during the process. Previous studies suggest that Ihh plays an important regulatory role in the growth and development of articular cartilage, but whether it is regulated by miRNAs is unclear. The present study aimed to investigate the effects of miR­1 on chondrocyte differentiation and matrix synthesis, and to determine whether miR­1 can regulate the Ihh signaling pathway. In the present study, the expression level of miR­1 was altered via transfection of the miR­1 mimic or inhibitor in mouse thorax chondrocytes, and the impact on chondrocyte phenotypes and Ihh expression was examined. Overexpression of miR­1 promoted the expression of the matrix synthesis­associated molecules collagen (Col)­II and aggrecan, two key components in cartilage matrix. Conversely, overexpression of miR­1 significantly downregulated the expression of chondrocyte differentiation markers Col­X and matrix metallopeptidase 13. Moreover, overexpression of miR­1 dose­dependently inhibited endogenous Ihh expression, and an association was observed between miR­1 and Ihh expression. The 3' untranslated region (UTR) of Ihh from various species contains two miR­1 binding sites. Luciferase reporter assays indicated that miR­1 post­transcriptionally suppressed Ihh expression, which was dependent on the binding of miR­1 to one of the two putative binding sites of the Ihh 3'UTR. Furthermore, via inhibition of Ihh expression, miR­1 decreased the expression of molecules downstream of Ihh in the Hedgehog signaling pathway in mouse thorax chondrocytes. This study provided new insight into the molecular mechanisms of miR­1 in regulating chondrocyte phenotypes via targeting the Ihh pathway.

14.
Neurosci Lett ; 735: 135166, 2020 09 14.
Artigo em Inglês | MEDLINE | ID: mdl-32574795

RESUMO

The trace amine-associated receptors (TAARs) are a second class of olfactory receptors in humans. They are activated by volatile amines, including pheromone-like odors. However, in humans the neural processing of TAAR-associated signals is not known. Using functional magnetic resonance imaging, the current study investigated brain activation following intra-nasal stimulation with trimethylamine (TMA), an agonist of human TAAR5, and three "canonical" odors with varied valence (an unpleasant odor [n-butanol], a neutral to unpleasant odor [civet musk], and a pleasant odor [phenyl ethyl alcohol]) in 12 healthy young participants. Our hypothesis driven analysis showed that TMA induced a trend for stronger left amygdala activation as compared to the other odors (Family-Wise Error corrected p = 0.08). Whole-brain exploratory analyses revealed superior activation of the cerebellum and caudate to TMA compared to canonical odors, and stronger activation of the anterior cingulate and somatosensory regions (postcentral gyrus and mid cingulate) in response to canonical odors compared to TMA. The current results provide initial evidence on differential central processes of a TAAR mediated stimulus compared to odors targeting canonical olfactory receptors. Future research are needed to elucidate the physiological and psychological relevance of TAARs in humans.

15.
Pest Manag Sci ; 76(9): 3149-3158, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32310328

RESUMO

BACKGROUND: PPO (prophenoloxidase) cascade plays an important role in resisting invasion of entomogenous fungus. The 20-hydroxyecdysone (20E) exerts potent effect on the innate immunity in many insects. However, whether 20E controls the PPO cascade system against fungi and the regulatory mechanism in insects remains unclear. RESULTS: In this study, both the proteome and transcriptome of Locusta migratoria were determined followed by the induction of 20E. Pattern recognition receptor GNBP-2 (Gram-negative binding proteins) has been identified that responded to 20E at both messenger RNA (mRNA) and protein levels. The PPO gene expression in fat body and PO (phenoloxidase) activity in plasma was found significantly induced after 20E injection and during the high-20E developmental stage. However, when 20E signal was blocked by RNA interference (RNAi) of ecdysone receptor, the expression level of PPO and PO activity failed to be increased by 20E. Thus, 20E could not significantly induce the expression of PPO gene and PO activity after RNAi of GNBP-2. Furthermore, 20E treatment notably enhanced the resistance of L. migratoria against Metarhizium anisopliae. Followed by of GNBP-2 silencing, the mortality of nymphs was significantly increased under the stress of Metarhizium anisopliae, and 20E injection could not increase the resistance. CONCLUSION: The 20E regulates the PPO system to resist fungal invasion via regulating GNBP-2 in worldwide pest L. migratoria. Our results provide insight into the mechanism of how 20E enhances the antimicrobial immunity, and will be beneficial for modification of entomogenous fungi targeting on hormones and the immune system. © 2020 Society of Chemical Industry.

16.
Brain Topogr ; 33(3): 403-411, 2020 05.
Artigo em Inglês | MEDLINE | ID: mdl-32297077

RESUMO

Patients with anosmia exhibit structural and functional brain abnormalities. The present study explored changes in brain white matter (WM) in non-neurodegenerative anosmia using diffusion-tensor-based network analysis. Twenty patients with anosmia and sixteen healthy controls were recruited in the cross-sectional, case-control study. Participants underwent olfactory tests (orthonasal and retronasal), neuropsychological assessment (cognitive function and depressive symptoms) and diffusion tensor imaging measurement. Tract-Based Spatial Statistics, graph theoretical analysis and Network-Based Statistics were used to explore the white matter. There was no significant difference in fractional anisotropy (FA) between patients and controls. In global network topological properties comparisons, patients exhibited higher γ and λ levels than controls, and both groups satisfied the criteria of small-world (σ > 1). In local network topological properties, patients had reduced betweenness, degree and efficiency (global and local), as well as increased shortest path length and cluster coefficient in olfactory-related brain areas (anterior cingulum, lenticular nucleus, putamen, hippocampus, amygdala, caudate nucleus, orbito-frontal gyrus). Olfactory threshold scores and the retronasal score were negatively correlated with γ and λ, and the retronasal score was positively correlated with FA values in certain WM tracts, i.e. middle cerebellar peduncle, right inferior cerebellar peduncle, left inferior cerebellar peduncle, right cerebral peduncle, left cerebral peduncle, left cingulum (cingulate gyrus), right cingulum (hippocampus), superior fronto-occipital fasciculus, and, left tapetum. Patients with anosmia demonstrated relevant WM network dysfunction though their structural integrity remained intact. Their retronasal olfaction deficits revealed to be more strongly associated with WM alterations compared with orthonasal olfactory scores.

17.
Med Sci Monit ; 26: e921540, 2020 Mar 03.
Artigo em Inglês | MEDLINE | ID: mdl-32123154

RESUMO

BACKGROUND Our objective was to establish and compare three-dimensional models of knee joints of mini-pigs and sheep, the 2 most commonly used animal models of osteoarthritis. MATERIAL AND METHODS Three-dimensional geometric models of knee joints were used to assess their biomechanical properties by analysis of the three-dimensional finite element stress load for flexion at 30° and 60°. RESULTS Analysis of multiple tissues indicated that the sheep knee had greater stress peaks than the mini-pig knee at 30° flexion (range: 12.5 to 30.4 Mpa for sheep vs. 11.1 to 20.2 Mpa for mini-pig) and at 60° flexion (range: 17.9 to 43.5 Mpa for sheep vs. 15.9 to 28.9 Mpa for mini-pig). In addition, there was uneven distribution of stress loads in the surrounding ligaments during flexion. CONCLUSIONS Our three-dimensional finite element analysis indicated that the mini-pig knee joint had stress values and changes of cartilage, meniscus, and peripheral ligaments that were similar to those of the human knee.

18.
Acta Otolaryngol ; 140(6): 509-513, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32125201

RESUMO

Background: Odor identification is related to odor naming, which is more of a verbal than an olfactory sensory task. Linguistic functions in right-handers are typically lateralized to the left hemisphere of the brain and the olfactory processing happens predominantly ipsilaterally to the stimulated side.Aims: Re-investigate side-related effect in healthy right-handed people with a larger sample size and investigate the influence of age or gender on the odor identification lateralization effect.Material and methods: The 'Sniffin' Sticks' odor identification test on a single nostril (either left or right side) was conducted in four hundred and thirty-eight right-handed participants. Among those one hundred and ninety-nine participants were tested on the left-side nostril and two hundred and thirty-nine on the right-side nostril. They were divided into two groups based on the age (18 years) or sex, in the older group (18 years) and the younger group (18 years) we had subgroups based on the sex.Results: In adults (age >18 years), the left-nostril odor identification score was significantly higher than the right-nostril odor identification score (t256 = 2.21, p = .03), in the male participants, the left-nostril odor identification score was also significantly higher than the right-nostril odor identification score (t147 = 2.01, p = 0.04).Conclusions and significance: The present study found that the in adult group (age >18 years), the odor identification performed better on the left-side nostril than the right-side nostril compared to the younger group (age ≤18 years); The males performed better on the left-side nostril than the right-side nostril compared to the females. In the adults (age >18 years) group, the males subgroup played a more important role on the lateralization of odor identification. Gender and age seem to have a large influence on the lateralization of odor identification.

19.
Chin J Traumatol ; 23(2): 96-101, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-32201231

RESUMO

With the deepening of research, proteomics has developed into a science covering the study of all the structural and functional characteristics of proteins and the dynamic change rules. The essence of various biological activities is revealed from the perspectives of the biological structure, functional activity and corresponding regulatory mechanism of proteins by proteomics. Among them, phospholipid-binding protein is one of the hotspots of proteomics, especially annexin A1, which is widely present in various tissues and cells of the body. It has the capability of binding to phospholipid membranes reversibly in a calcium ion dependent manner. In order to provide possible research ideas for researchers, who are interested in this protein, the biological effects of annexin A1, such as inflammatory regulation, cell signal transduction, cell proliferation, differentiation and apoptosis are described in this paper.


Assuntos
Anexina A1/fisiologia , Apoptose/genética , Proliferação de Células/genética , Inflamação/genética , Transdução de Sinais/genética , Cálcio/metabolismo , Humanos , Fosfolipídeos/metabolismo , Ligação Proteica , Proteômica
20.
Brain Res ; 1730: 146663, 2020 03 01.
Artigo em Inglês | MEDLINE | ID: mdl-31931000

RESUMO

Repeated sensory exposure through frequent consumption of certain foods leads to changes in the processing of sensory cues. We investigated the influence of frequent minty chewing gum consumption on the neurobehavioral processing of intranasal trigeminal and olfactory stimuli. fMRI responses to a trigeminal minty odor (L-menthol), a non-trigeminal minty odor (L-carvone), and a non-trigeminal non-minty odor (strawberry) were assessed in 29 young adults (mean age = 23 years, SD = 4.3 years; mean BMI = 22.7, SD = 1.9; thirteen females), who were divided into a minty chewing gum high frequency (N = 18) and a low infrequency (N = 11) groups based on their self-reported frequency of chewing gum consumption. Participants' performance for odor lateralization, ratings for perceived odor intensity, pleasantness, familiarity, and pungency were also collected. Compared to the low frequency group, the high frequency group rated L-menthol as more familiar and performed better during the L-menthol lateralization test. The high frequency group compared to low frequency group showed stronger activation in trigeminal and somatosensory brain regions during perception of trigeminal component. These findings suggest an association between frequent minty odor exposure and increased neurobehavioral sensitivity to intranasal trigeminal stimulation.

SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...