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1.
Artigo em Inglês | MEDLINE | ID: mdl-34741268

RESUMO

Uranium tailing ponds are a potential major source of radioactive pollution. Solidification treatment can control the diffusion and migration of radioactive elements in uranium tailings to safeguard the surrounding ecological environment. A literature review and field investigation were conducted in this study prior to fabricating 11 solidified uranium tailing samples with different proportions of PVA fiber, basalt fiber, metakaolin, and fly ash, and the weight percentage of uranium tailings in the solidified body is 61.11%. The pore structure, volume resistivity, compressive strength, radon exhalation rate variations, and U(VI) leaching performance of the samples were analyzed. The pore size of the solidified samples is mainly between 1 and 50 nm, the pore volume is between 2.461 and 5.852 × 10-2 cm3/g, the volume resistivity is between 1020.00 and 1937.33 Ω·m, and the compressive strength is between 20.61 and 36.91 MPa. The radon exhalation rate is between 0.0397 and 0.0853 Bq·m-2·s-1. The cumulative leaching fraction of U(VI) is between 2.095 and 2.869 × 10-2 cm, and the uranium immobilization rate is between 83.46 and 85.97%. Based on a comprehensive analysis of the physical and mechanical properties, radon exhalation rates, and U(VI) leaching performance of the solidified samples, the basalt fiber is found to outperform PVA fiber overall. The solidification effect is optimal when 0.6% basalt fiber is added.

2.
Phys Chem Chem Phys ; 23(39): 22685-22691, 2021 Oct 13.
Artigo em Inglês | MEDLINE | ID: mdl-34604887

RESUMO

Bulk-heterojunction (BHJ) organic solar cells (OSCs) exhibit ultrafast charge separation (UCS) which enables lower geminate charge recombination and high internal quantum efficiency. Unravelling why UCS occurs in BHJ-OSCs is important for the exploration of devices in future, however it is still far from clear. In this work, we build a multichain tight-binding model to study the conditions for realizing UCS. We propose that two conditions are important: (i) the BHJ-OSC has a morphology with donor and acceptor molecules being individually aggregated; (ii) the ratio of the donor/acceptor interfacial coupling to the internal donor/donor and acceptor/acceptor coupling should be smaller than a threshold. In addition, we suggest that increasing the donor/acceptor energetic offset will boost the UCS efficiency. As a fundamental theoretical analysis on the underlying mechanism of UCS, our work provides design rules for optimizing high-performance BHJ OSCs.

3.
Phys Chem Chem Phys ; 23(41): 23818-23826, 2021 Oct 27.
Artigo em Inglês | MEDLINE | ID: mdl-34647116

RESUMO

In recent years, although the power conversion efficiency (PCE) of thermally stable all-inorganic CsPbI3 perovskite solar cells (PSCs) had shown a great progress, the most reported CsPbI3 PSCs suffered from the large open-circuit voltage (Voc) loss, which is related to severe nonradiative recombination and a mismatch in energy level at the transport layer/perovskite interface. In this work, europium acetate (EuAc3) as a multifunction interface material is chosen to modify the TiO2/perovskite interface, the crystal quality of CsPbI3 perovskite films is improved, and both bulk and interfacial defects are reduced effectively. Meanwhile, the energy levels arrangement between TiO2 and CsPbI3 perovskites is also optimized, corresponding the raised built-in electric field afford a strength force to accelerate the transport and extraction of charge carriers from CsPbI3 perovskites to TiO2. As a result, the performance of CsPbI3 PSCs is largely enhanced with the PCE of 16.76%. When an Ag electrode was replaced by Au, the PCE further improves to 17.92%, which is the highest for CsPbI3 PSCs with P3HT as the HTL ever reported. Besides, the CsPbI3 PSC with the EuAc3 modification layer maintains 84% of the initial PCE under continuous UV irradiation for 250 h in a nitrogen filled glovebox, being obviously higher than the control devices with only 40% of the initial PCE after UV irradiation for 100 h in the same environment.

4.
Sci Total Environ ; : 151042, 2021 Oct 19.
Artigo em Inglês | MEDLINE | ID: mdl-34673074

RESUMO

The misuse of both antibiotics and plastics significantly increases the environmental pollution problems associated with these contaminants. Moreover, microplastics can adsorb other pollutants in the environment. However, the mechanisms of antibiotic adsorption by degradable and nondegradable microplastics are not completely understood. In this study, we investigated the environmental behavior of norfloxacin (NOR) using polybutylene succinate (PBS), which is a degradable microplastic, and compared it with conventional microplastics, polystyrene (PS) and polyethylene (PE). The order of adsorption capacity was PS > PBS â‰« PE. The adsorption behavior fitted well with the pseudo-second-order kinetic and Langmuir isotherm models, indicating monolayer adsorption. The process is thermodynamically endothermic and non-spontaneous and is controlled by chemical and physical mechanisms, including π-π conjugation, hydrogen bonds, ion exchange, and electrostatic interactions. The adsorption capacity of microplastics was higher when the solution pH was around the pKa value of NOR than at other pH values. Ionic strength and dissolved organic matter inhibited the adsorption process. For PS and PBS, the amount of NOR adsorbed onto MPs initially decreased and then increased with the increase of coexisting heavy metal ions. Zn2+ and Pb2+ could promote the adsorption of NOR by PE. This study reveals the interaction mechanisms between microplastics and antibiotics and provides a more comprehensive theoretical basis for an ecological environmental risk assessment of different microplastics.

5.
Transl Lung Cancer Res ; 10(3): 1424-1443, 2021 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-33889520

RESUMO

Background: Neutrophils can play a pro-tumor or anti-tumor role depending on the tumor microenvironment. The effects of concurrent treatment with granulocyte colony-stimulating factor (G-CSF) and radiotherapy (RT) on neutrophils have not yet to be described. Methods: Hypofractionated radiation of 8 Gy ×3 fractions was administered with or without recombinant G-CSF to Lewis lung carcinoma tumor-bearing C57BL/6 model mice. The activation status of cytotoxic T cells in the mice was measured, along with the levels of tumor-associated neutrophils, cytotoxic T cells, and Treg cells. Tumor growth, survival, cytokine expression, and signaling pathways underlying anti-tumor effects of tumor-associated neutrophils after treatment were also studied. To ascertain the effects of concurrent RT and G-CSF on tumor-associated neutrophils, neutrophil depletion was performed. Results: RT affected early neutrophil infiltration, which is the first-line immune response. Subsequently, enhanced accumulation of lymphocytes, particularly CD8 cytotoxic T cells, was observed. Notably, lymphocytic infiltration was inhibited by neutrophil depletion but enhanced by G-CSF treatment. RT generated persistent DNA damage, as evidenced by an accumulation of phosphorylation of histone H2AX (γH2AX), and subsequently triggered inflammatory chemokine secretion. The chemokines CXCL1, CXCL2, and CCL5 were upregulated in both radiation-treated cells and the corresponding supernatants. Neutrophils that were newly recruited after RT improved radiosensitivity by inhibiting epithelial-mesenchymal transition via the reactive oxygen species-mediated PI3K/Akt/Snail signaling pathway, and G-CSF treatment enhanced this effect. Conclusions: The results of this study suggest that RT activates neutrophil recruitment and polarizes newly recruited neutrophils toward an antitumor phenotype, which is enhanced by the concurrent administration of G-CSF. Mesenchymal-epithelial transition induced by reactive oxygen species accumulation plays a major role in this process. Thus, the polarization of tumor-associated neutrophils might play a role in future cancer immunotherapies.

6.
Nanotechnology ; 32(48)2021 Sep 08.
Artigo em Inglês | MEDLINE | ID: mdl-33647887

RESUMO

Perovskite solar cells (PSCs) are important candidates for next-generation thin-film photovoltaic technology due to their superior performance in energy harvesting. At present, their photoelectric conversion efficiencies (PCEs) are comparable to those of silicon-based solar cells. PSCs usually have a multi-layer structure. Therefore, they face the problem that the energy levels between adjacent layers often mismatch each other. Meanwhile, large numbers of defects are often introduced due to the solution preparation procedures. Furthermore, the perovskite is prone to degradation under ultraviolet (UV) irradiation. These problems could degrade the efficiency and stability of PSCs. In order to solve these problems, quantum dots (QDs), a kind of low-dimensional semiconductor material, have been recently introduced into PSCs as charge transport materials, interfacial modification materials, dopants and luminescent down-shifting materials. By these strategies, the energy alignment and interfacial conditions are improved, the defects are efficiently passivated, and the instability of perovskite under UV irradiation is suppressed. So the device efficiency and stability are both improved. In this paper, we overview the recent progress of QDs' utilizations in PSCs.

7.
Ann Transl Med ; 8(22): 1507, 2020 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-33313252

RESUMO

Background: Tumor-associated neutrophils (TANs) have been a research hotspot in recent years. However, the role and relevant mechanisms of TANs in the tumor microenvironment (TME) have not yet been elucidated. Method: The ribonucleic acid (RNA) expression levels of fucosyltransferase 4 (FUT4) and elastase, neutrophil expressed (ELANE) in samples from The Cancer Genome Atlas (TCGA) (n=4,538) were analyzed. Receiver operating characteristic (ROC) curves were used to calculate the critical cutoff values, and different data were defined as high and low expression. The tumor microenvironment immune type (TMIT) was defined according to the activation state of TAN, and the samples were classified into three TMITs based on their cut-off values. Mutational datasets and overall survival were compared according to the TMITs. Results: The prognostic significance of FUT4, ELANE, and myeloperoxidase (MPO) was different among the 15 cancers, and the prognostic significance of different TMITs varied across the different tumors. Compared with the other groups, TMIT 3 had a favorable prognostic effect, which was most prominent in lung adenocarcinoma (LUAD) [hazard ratio (HR) =0.292, 95% confidence interval (CI): 0.185-0.459, P<0.001]. Conclusions: Our study demonstrated that highly-activated TANs predicted a favorable prognosis in humans using genomic analyses for the first time. This provides a realistic basis for further exploring the role of TANs in the immune microenvironment and provides real world data for tumor immunotherapy.

8.
ACS Appl Mater Interfaces ; 12(49): 55342-55348, 2020 Dec 09.
Artigo em Inglês | MEDLINE | ID: mdl-33249830

RESUMO

Charge extraction layers with excellent charge extraction capability are essential for achieving high photovoltaic performance in cells. In this work, a hole extraction layer (HEL) is developed by doping conductive polymer TFB into CuSCN (CuSCN:TFB(X)), which exhibits good light transparency and high affinity for the light absorber. Compared to the reference cell, the CuSCN:TFB(X) HEL-based cells show impressive enhancement owing to the increased exciton dissociation and charge extraction processes and weak recombination losses. Furthermore, matched work function, better interface contact, and appropriate domain size also contribute to the enhanced power conversion efficiency. As a consequence, the highest conversion efficiency of 15.28% is observed in a cell based on the PM6:Y6 blend film and CuSCN:TFB(1.0%) HEL, which is >16% higher than the efficiency of 13.13% in a cell with CuSCN HEL.

9.
ACS Appl Mater Interfaces ; 12(40): 45073-45082, 2020 Oct 07.
Artigo em Inglês | MEDLINE | ID: mdl-32921039

RESUMO

Interface engineering has been recognized as a very effective method to simultaneously improve both efficiency and stability in perovskite solar cells (PSCs). In this work, we report using an excellent small molecular material tetraphenyldibenzoperiflanthene (DBP) to modify the perovskite/Spiro-OMeTAD interface to achieve significantly improved solar cell performance. It is found that the ultrathin DBP interlayer accelerates hole transfer across the FAxMA1-xPbInBr3-n/Spiro-OMeTAD interface and effectively reduces the nonradiative recombination. The Kelvin probe force microscopy and energy band analyses reveal that the DBP modification helps build better matched energy level alignment and smaller energy loss for more fluent hole transport. Consequently, the DBP-treated PSCs achieve an enhanced open-circuit voltage as high as 1.184 V and fill factor as high as 78.2% as well as the negligible hysteresis. The champion PSC made with DBP gives a PCE of 21.49%, significantly increased compared to 19.68% from the reference cell without the modification. Moreover, DBP also serves as a water-resistant protection for improved moisture stability. The PCE of the DBP-treated cells without encapsulation remains more than 84% of its initial efficiency, which is significantly higher than that of the reference PSCs (65%) after 20 days of storage under an air environment with 50-65% humidity. This study provides an effective interface modification material to address notorious stability problems in Spiro-OMeTAD-based PSCs.

10.
ACS Appl Mater Interfaces ; 12(41): 46373-46380, 2020 Oct 14.
Artigo em Inglês | MEDLINE | ID: mdl-32945159

RESUMO

The hole transporting layers (HTLs) between the electrode and light absorber play a vital role in charge extraction and transport processes in organic solar cells (OSCs). Herein, a bilayer structure HTL of CuSCN/TFB is formed by soluble copper(I) thiocyanate (CuSCN) and poly[(9,9-dioctylfluorenyl-2,7-diyl)-alt-(4,4'-(N-(4-butylphenyl)))] (TFB). The excellent charge extraction capability is proved in nonfullerene PM6:Y6 and fullerene PTB7-Th:PC71BM blend system-based cells. The introduction of TFB tunes the work function and polishes the interfacial contact between the HTL and light absorber, which favors the hole extraction process in cells. Meanwhile, lower recombination loss, higher exciton dissociation probability, and larger domain size are observed in CuSCN/TFB HTL-based cells compared to those of the reference cell with the pristine CuSCN HTL, which significantly improve the photovoltaic performance. As a result, a champion efficiency of 15.10% is obtained, which is >14% higher than the efficiency of 13.15% obtained in the reference cell. This study suggests that CuSCN/TFB is a promising HTL to achieve high efficiency for OSCs.

11.
Nanotechnology ; 31(31): 314001, 2020 Jul 31.
Artigo em Inglês | MEDLINE | ID: mdl-32268316

RESUMO

Flexible and lightweight photomultiplication-type organic photodetectors (PM-OPDs) have attracted wide attention for their broad application prospects, especially in the field of wearable electronic products. However, the commonly used indium tin oxide (ITO) conductive anode is not conducive to realize high-performance flexible PM-OPDs due to its rigidity and fragility. Here, on the flexible polyethylene terephthalate (PET) substrate, we successfully fabricate highly sensitive poly 3-hexylthiophene:phenyl-C70-butyric acid methyl ester (P3HT:PC70BM, 100:1) based PM-OPDs using ultra-thin silver films as transparent anodes. Specifically, a 1 nm thick MoO3 layer is utilized as the wetting layer for facilitating the silver film percolation, and a 2 nm thick MoO3 layer, as the hole transport layer, is coated on top of the ultra-thin silver film before coating the P3HT:PC70BM film. The as-prepared flexible PM-OPDs based on the ultra-thin silver film exhibit the optimal external quantum efficiency (EQE) and responsivity (R) of 1.3 × 105% and 388.4 A W-1, respectively, under -15 V bias, which are 1.98 times and 2.15 times greater than those of the ITO anode based device. More importantly, the device has good flexibility with the EQE maintaining 70.6% of its initial value after bending 10 times, and 51.4% of its initial value after bending 1000 times. This work paves the way for developing flexible PM-OPDs as well as other flexible optoelectronic devices.

12.
J Nanosci Nanotechnol ; 20(5): 3283-3286, 2020 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-31635676

RESUMO

Conductive filament mechanism can explain major resistance switching behaviors. The forming/deforming of the filaments define the high/low resistance states. The ratio of high/low resistance depends on the characterization of the filaments. In many oxide systems, the oxygen vacancies are important to forming the conductive filaments for the resistance switching behaviors. As ultrawide band gap semiconductor, Ga2O3 has very high resistance for its high resistance state, while its low resistive state has relative high resistance, which normally results in low ratio of high/low resistance. In this letter, we report a high ratio of high/low resistance by ultraviolet radiation. The I-V characteristics of Au/Ti/ß-Ga2O3/W sandwich structure device shows that the HRS to LRS ratio of 5 orders is achieved.

13.
Transl Lung Cancer Res ; 9(6): 2440-2459, 2020 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-33489805

RESUMO

Background: Radiation-induced lung injury (RILI) is a common complication of thoracic cancer radiation therapy. Currently, there is no effective treatment for RILI. RILI is associated with chronic inflammation, this injury is perpetuated by the stimulation of chemokines and proinflammatory cytokines. Recent studies have demonstrated that granulocyte-macrophage colony-stimulating factor (GM-CSF) plays a pivotal role in inflammation and fibrosis. This study aimed to investigate the protective effect of GM-CSF against the development of RILI in lung tissue. Method: First, a single fraction of radiation at a dose of 16 Gy was targeted at the entire thorax of wild-type (WT) C57BL/6 mice and GM-CSF-/- mice to induce RILI. Second, we detected the radioprotective effects of GM-CSF by measuring the inflammatory biomarkers and fibrosis alteration on radiated lung tissues. Furthermore, we investigated the potential mechanism of GM-CSF protective effects in RILI. Results: The GM-CSF-/- mice sustained more severe RILI than the WT mice. RILI was significantly alleviated by GM-CSF treatment. Intraperitoneally administered GM-CSF significantly inhibited inflammatory cytokine production and decreased epithelial-mesenchymal transition (EMT) in the RILI mouse model. Conclusions: GM-CSF was shown to be an important modulator of RILI through regulating inflammatory cytokines, which provides a new strategy for the prevention and treatment of RILI.

14.
Ann Transl Med ; 7(20): 525, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31807507

RESUMO

Background: The prognostic role and underlying heterogeneity of negative lymph nodes (NLNs) on colon cancer is not well understood. The purpose of this study was to construct NLN-based prognostic models and reveal relevant mechanisms affecting NLNs by analyzing omic data. Methods: This inception cohort study included 314,398 colon cancer patients from the US Surveillance, Epidemiology, and End Results (SEER) database. Receiver operating characteristic (ROC) curve was used to determine the cut-off of NLNs. Nomograms were constructed and validated using SEER data and the Cancer Genome Atlas (TCGA) data, respectively. The differentially expressed genes (DEGs) were analyzed using edgeR. Enrichment analyses were performed by Metascape. Results: Multivariate analysis confirmed the high NLN had improved cancer-specific survival (CSS) and overall survival (OS) compared to low NLN [hazard ratio (HR) =0.610, 95% confidence interval (CI), 0.601-0.620] for CSS and (HR =0. 682, 95% CI, 0.674-0.690) for OS. Nomograms were established for CSS and OS with the c-statistic 0.790 (95% CI, 0.788-0.792) for CSS and 0.734 (95% CI, 0.732-0.736) for OS. High NLN was associated with less B cell (P=0.002) and macrophage infiltration (P<0.0001), high microsatellite instability (MSI) (OR =4.325, P=0.001), and hypermutation (OR =4.285, P=0.001; high vs. low). Transcriptomics analysis demonstrated histone modifiers were the most significant different biological processes between the high and low NLN group. Conclusions: The NLN-based models can aid in personalized risk stratification for colon cancer. This study postulates that high NLN may represent a biological subtype with less macrophage infiltration, high MSI status, hypermutation, and histone modifier gene enriched expression, and thus warrants further investigation.

15.
Opt Express ; 27(12): A596-A610, 2019 Jun 10.
Artigo em Inglês | MEDLINE | ID: mdl-31252840

RESUMO

A silver grating containing three grooves with different depths in one period was proposed as the back electrode for improving light absorption in organic solar cells. We found that the broadband absorption enhancement of the active layer covering the visible and near-infrared bands can be obtained due to the excitation of surface plasmon resonance and the multiple resonances of cavity mode. The integrated absorption efficiency of the proposed structure under TM polarization between 350 nm to 900 nm is 57.4%, with consideration of the weight of AM 1.5G solar spectrum, and is increased by 13.4% with respect to the equivalent planar device. Besides, the wide-angle absorption in proposed structure can be observed in the range from 0 to 50 degrees. These findings are of great importance for rationally designing composite nanostructures of metal gratings-based absorbers for sensing and photon-detecting applications.

16.
Neurochem Int ; 121: 19-25, 2018 12.
Artigo em Inglês | MEDLINE | ID: mdl-30352262

RESUMO

Reticulons (RTNs) are a family of membrane-bound proteins that are dominantly localized to the endoplasmic reticulum (ER) membrane. RTN1-C is one member of RTNs abundantly expressed in the brain and has been shown to mediate neuronal injury in cerebral ischemia models. In the present study, we investigated the role of RTN1-C in an in vitro brain trauma model mimicked by traumatic neuronal injury (TNI) in primary cultured cortical neurons. TNI increased the expression of RTN1-C in cortical neurons but had no effect on RTN1-A and RTN1-B. Knockdown of RTN1-C with specific siRNA (Si-RTN1-C) significantly decreased cytotoxicity and apoptosis after TNI. The results of Ca2+ imaging showed that intracellular Ca2+ overload induced by TNI was attenuated by RTN1-C knockdown. Furthermore, the activation of metabotropic glutamate receptor 1 (mGluR1)-induced Ca2+ response was partially prevented by Si-RTN1-C transfection. We also evaluated the role of RTN1-C in store-operated Ca2+ entry (SOCE) in cortical neurons using the ER Ca2+ inducer thapsigargin (Tg). The results showed that knockdown of RTN1-C alleviated the SOCE-mediated Ca2+ influx and decreased the expression of stromal interactive molecule 1 (STIM1). In summary, the present study found that knockdown of RTN1-C protected neurons against TNI via preservation of intracellular Ca2+ homeostasis, which was associated with the inhibition of mGluR1-mediated ER Ca2+ release and suppression of STIM1-related SOCE. Thus, RTN1-C might represent a therapeutic target for traumatic brain injury (TBI) research.


Assuntos
Sinalização do Cálcio/fisiologia , Homeostase/fisiologia , Líquido Intracelular/metabolismo , Proteínas do Tecido Nervoso/biossíntese , Neurônios/metabolismo , Neurônios/patologia , Animais , Células Cultivadas , Córtex Cerebral/metabolismo , Córtex Cerebral/patologia , Técnicas de Silenciamento de Genes/métodos , Proteínas do Tecido Nervoso/antagonistas & inibidores , Proteínas do Tecido Nervoso/genética , Ratos , Ratos Sprague-Dawley
17.
Nanomaterials (Basel) ; 8(9)2018 Sep 11.
Artigo em Inglês | MEDLINE | ID: mdl-30208639

RESUMO

Organic photomultiplication photodetectors have attracted considerable research interest due to their extremely high external quantum efficiency and corresponding high detectivity. Significant progress has been made in the aspects of their structural design and performance improvement in the past few years. There are two types of organic photomultiplication photodetectors, which are made of organic small molecular compounds and polymers. In this paper, the research progress in each type of organic photomultiplication photodetectors based on the trap assisted carrier tunneling effect is reviewed in detail. In addition, other mechanisms for the photomultiplication processes in organic devices are introduced. Finally, the paper is summarized and the prospects of future research into organic photomultiplication photodetectors are discussed.

18.
Front Chem ; 6: 398, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30246008

RESUMO

In this paper, urea-doped ZnO (U-ZnO) is investigated as a modified electron transport layer (ETL) in inverted polymer solar cells (PSCs). Using a blend of Poly{4,8-bis[(2-ethylhexyl)oxy] benzo [1,2-b:4,5-b'] dithiophene-2,6-diyl-alt-3-fluoro-2-[(2-ethylhexyl)carbonyl] thieno [3,4-b] thiophene-4,6-diyl}(PTB7), and [6,6]-phenyl-C71-butyric acid methyl ester (PC71BM) as light absorber, a champion power conversion efficiency (PCE) of 9.15% for U-ZnO ETL based PSCs was obtained, which is 15% higher than that of the pure ZnO ETL based PSCs (7.76%). It was demonstrated that urea helps to passivate defects in ZnO ETL, resulting in enhanced exciton dissociation, suppressed charge recombination and efficient charge extraction efficiency. This work suggests that the utilization of the U-ZnO ETL offer promising potential for achieving highly efficient PSCs.

19.
Biomaterials ; 181: 92-102, 2018 10.
Artigo em Inglês | MEDLINE | ID: mdl-30081305

RESUMO

Understanding the relationship between polymer chemical structure and its performance of photoacoustic imaging (PAI) and photothermal therapy (PTT) is important for developing ideal PAI/PTT agents. In this report, four semiconducting polymer nanoparticles (SPNs) with different donor-acceptor architectures are self-assembled for highly effective PAI-guided PTT. In particular, SPN1 with the longest π-conjugation length and the highest mass extinction coefficient which are beneficial for intramolecular charge transfer as well as light harvesting, exhibits the highest photothermal conversion efficiency up to 52.6%. Moreover, the as-prepared SPN1 possess good water-dispersibility, robust size-stability and excellent photothermal properties. Furthermore, the SPN1 not only exhibits a remarkable cancer cell-killing ability but also shows a prominent tumor inhibition capacity. Finally, the as-prepared water-dispersible SPN1 displays good biocompatibility and biosafety, making it a promising candidate for future biomedical applications. Considering the plenty of near-infrared absorbing semiconducting polymer available, our work provides fundamental insights for rational design and preparation of highly efficient SPN-based PAI/PTT agents for cancer theranostics.


Assuntos
Nanopartículas/química , Técnicas Fotoacústicas/métodos , Fototerapia/métodos , Polímeros/química , Semicondutores , Nanomedicina Teranóstica/métodos , Células A549 , Animais , Feminino , Humanos , Camundongos , Camundongos Nus
20.
Adv Mater ; 30(38): e1803244, 2018 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-30091807

RESUMO

Antimonene-based 2D materials are attracting increasing research interest due to their superior physicochemical properties and promising applications in next-generation electronics and optoelectronics devices. However, the semiconductor properties of antimonene are still at the theoretical simulation stage and are not experimentally verified, significantly restricting its applications in specific areas. In this study, the semiconductor properties of monolayer antimonene nanosheets are experimentally verified. It is found that the obtained semiconductive antimonene nanosheets (SANs) exhibit indirect bandgap properties, with photoluminescence (PL) bandgap at about 2.33 eV and PL lifetime of 4.3 ns. Moreover, the obtained SANs are ideal for the hole extraction layer in planar inverted perovskite solar cells (PVSCs) and significantly enhance the device performance due to fast hole extraction and efficient hole transfer at the perovskite/hole transport layer interface. Overall, these findings look promising for the future prospects of antimonene in electronics and optoelectronics.

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