Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Zhongguo Dang Dai Er Ke Za Zhi ; 13(5): 415-8, 2011 May.
Artigo em Chinês | MEDLINE | ID: mdl-21575350

RESUMO

OBJECTIVE: To study the mechanism of brain development delay in rats with intrauterine growth retardation (IUGR) by examining the expression of nerve growth factor (NGF) and tyrosine kinase receptor A (Trk A) in the brain. METHODS: Thirty-two pregnant rats were randomly fed with a normal diet (control group) or lower protein diet (IUGR group) during pregnancy (n=16 each). The pup rats were sacrificed at 0, 7, 14 or 21 days after birth. The protein levels of NGF and TrkA in the brain were determined by Western blot and immunohistochemistry staining. RESULTS: The levels of NGF and TrkA in the brain in pup rats of the IUGR group were significantly lower than those in the control group 0, 7, 14 and 21 days after birth. CONCLUSIONS: The decreased expression of protein levels of NGF and TrkA in the brain might be one of the causes of brain development delay in IUGR rats.


Assuntos
Química Encefálica , Retardo do Crescimento Fetal/metabolismo , Fator de Crescimento Neural/análise , Receptor trkA/análise , Animais , Peso ao Nascer , Feminino , Morte Fetal/epidemiologia , Retardo do Crescimento Fetal/epidemiologia , Imuno-Histoquímica , Gravidez , Ratos , Ratos Wistar
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...