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Sensors (Basel) ; 17(12)2017 Nov 30.
Artigo em Inglês | MEDLINE | ID: mdl-29189728


Four-transistor (T) pinned photodiode (PPD) CMOS image sensors (CISs) with four-megapixel resolution using 11µm pitch high dynamic range pixel were radiated with 3 MeV and 10MeV protons. The dark signal was measured pre- and post-radiation, with the dark signal post irradiation showing a remarkable increase. A theoretical method of dark signal distribution pre- and post-radiation is used to analyze the degradation mechanisms of the dark signal distribution. The theoretical results are in good agreement with experimental results. This research would provide a good understanding of the proton radiation effects on the CIS and make it possible to predict the dark signal distribution of the CIS under the complex proton radiation environments.

Zhongguo Dang Dai Er Ke Za Zhi ; 13(5): 415-8, 2011 May.
Artigo em Chinês | MEDLINE | ID: mdl-21575350


OBJECTIVE: To study the mechanism of brain development delay in rats with intrauterine growth retardation (IUGR) by examining the expression of nerve growth factor (NGF) and tyrosine kinase receptor A (Trk A) in the brain. METHODS: Thirty-two pregnant rats were randomly fed with a normal diet (control group) or lower protein diet (IUGR group) during pregnancy (n=16 each). The pup rats were sacrificed at 0, 7, 14 or 21 days after birth. The protein levels of NGF and TrkA in the brain were determined by Western blot and immunohistochemistry staining. RESULTS: The levels of NGF and TrkA in the brain in pup rats of the IUGR group were significantly lower than those in the control group 0, 7, 14 and 21 days after birth. CONCLUSIONS: The decreased expression of protein levels of NGF and TrkA in the brain might be one of the causes of brain development delay in IUGR rats.

Química Encefálica , Retardo do Crescimento Fetal/metabolismo , Fator de Crescimento Neural/análise , Receptor trkA/análise , Animais , Peso ao Nascer , Feminino , Morte Fetal/epidemiologia , Retardo do Crescimento Fetal/epidemiologia , Imuno-Histoquímica , Gravidez , Ratos , Ratos Wistar