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1.
J Hazard Mater ; 421: 126794, 2022 01 05.
Artigo em Inglês | MEDLINE | ID: mdl-34365236

RESUMO

Conversion of digestate into biochar-based catalysts is an effective strategy for disposal and resource utilization. The active sites on biochar correlated with reactive species formation in peroxymonosulfate (PMS) system directly. Clarifying the structure-performance relationship of digestate derived biochar in PMS system was essential for decomposition of contaminants. Herein, dairy manure digestate derived biochar (DMDB) was prepared for PMS activation and sulfamethoxazole (SMX) degradation. The higher pyrolysis temperature could promote effective sites generation. Especially, the DMDB-800 catalyst exhibited excellent performance for PMS activation, achieving 90.2% degradation of SMX within 60 min. Based on the correlation analysis between log (k) values and active sites, defects, graphite N and CO were identified as dominant sites for PMS activation. The 1O2 oxidation and surface electron transfer were critical routes for SMX degradation. Besides, the degradation pathways of SMX were proposed according to DFT calculations and intermediates determination. The cleavage of the sulfonamide bond, hydroxylation of the benzene ring and oxidation of the amino group mainly occurred during SMX degradation. Overall, this study provides deep insights into the enhanced mechanism of tunable active sites on DMDBs for PMS activation, boosting the application of digestate biochar for water treatment in advanced oxidation systems.


Assuntos
Biocombustíveis , Peróxidos , Domínio Catalítico , Carvão Vegetal , Sulfanilamida
2.
Chemosphere ; 286(Pt 2): 131804, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34365167

RESUMO

Perfluorooctanoic acid (PFOA) is of increasing concern due to its worldwide application and extremely environmental persistence. Herein, we demonstrated the electrochemical degradation of PFOA with high efficiency using the Ti3+ self-doping TiO2 nanotube arrays (Ti3+/TiO2-NTA) anode. The fabricated Ti3+/TiO2-NTA anode exhibited vertically aligned uniform nanotubes structure, and was demonstrated good performance on the electrochemical degradation of PFOA in water. The degradation rate, total organic carbon (TOC) removal rate and defluorination rate of PFOA reached 98.1 %, 93.3 % and 74.8 %, respectively, after electrolysis for 90 min at low current density of 2 mA cm-2. The energy consumption (7.6 Wh L-1) of this electrochemical oxidation system using Ti3+/TiO2-NTA anode for PFOA degradation was about 1 order of magnitude lower than using traditional PbO2 anodes. Cathodic polarization could effectively prolong the electrocatalytic activity of the anode by regenerating Ti3+ sites. PFOA molecular was underwent a rapidly mineralization to CO2 and F-, with only low concentration of short-chain perflfluorocarboxylic acids (PFCAs) intermediates identified. A possible electrochemical degradation mechanism of PFOA was proposed, in which the initial direct electron transfer (DET) on the anode to yield PFOA free radicals (C7F15COO•) and hydroxyl radicals (•OH) oxidation were greatly enhanced. This presented study provides a novel approach for the purification of the recalcitrant PFOA from wastewaters.


Assuntos
Nanotubos , Poluentes Químicos da Água , Eletrodos , Fluorcarbonetos , Titânio , Poluentes Químicos da Água/análise
3.
J Pharm Biomed Anal ; 207: 114400, 2022 Jan 05.
Artigo em Inglês | MEDLINE | ID: mdl-34624818

RESUMO

A sensitive and ratiometric electrochemical biosensor was developed for the determination of dimethoate via alkaline phosphatase (ALP) mediated dissolution of nano-MnO2 and [Ru(NH3)6]3+(Ru(III)) redox recycling. The electroactive probe Ru(III) was adsorbed on the nano-MnO2 with the high specific surface area through electrostatic interaction to form the MnO2-Ru(III) nanocomposite, which was then fixed on the surface of the glassy carbon electrode. When the dimethoate inhibited the catalytic activity of ALP in a homogeneous system, the hydrolysate L-ascorbic acid (AA) produced by ALP hydrolysis of L-ascorbic acid-trisodium 2-phosphate (AAP) decreased. The solution was then incubated with a glassy carbon electrode modified by MnO2-Ru(III). At this time, only a small amount of MnO2-Ru(III) was decomposed and Ru(III) was rapidly electroreduced to Ru(II) on the surface of the electrode. The in-situ produced Ru(II) was chemically oxidized back to Ru(III) by Fe(III). The redox recycling of Ru(III) was completed and the Ru(III) reduction current signal was amplified. The process consumed part of Fe(III) to reduce the reduction current signal of Fe(III), and the ratio of the two reduction currents (IRu(III)/IFe(III)) increased significantly. The IRu(III)/IFe(III) value increased with the increase of dimethoate concentration in the linear range of 0.01-300 ng mL-1, and the detection limit was 6.3 pg mL-1. It has been successfully applied to the determination of dimethoate in oilseed rape and lettuce with a satisfactory result.


Assuntos
Fosfatase Alcalina , Técnicas Biossensoriais , Dimetoato , Compostos Férricos , Compostos de Manganês , Oxirredução , Óxidos , Solubilidade
4.
J Colloid Interface Sci ; 608(Pt 2): 1983-1998, 2021 Oct 30.
Artigo em Inglês | MEDLINE | ID: mdl-34749147

RESUMO

Active sites on catalyst surface play significant roles in oxidative species formation. The work focused on the regulation of main active sites on catalyst surface and oxidative species formation. Herein, sewage sludge (SS)-red mud (RM) complex biochar (SRCB) and N-functionalized SRCB (NSRCB) were served as activators of peroxymonosulfate (PMS) for sulfanilamide (SMX) degradation. Specially, NSRCB-1 showed excellent catalytic performance with 97.5% removal of SMX within 110 min. Additionally, the effects of N incorporation on the reconstruction of N species, conversion of intrinsic Fe species and ketonic CO groups in SRCB were studied systematically. Both radical (hydroxyl radicals (OH), sulfate radicals (SO4-) and superoxide radical (O2-)) and non-radical (electron transfer and singlet oxygen (1O2)) pathways were confirmed by quenching experiments, electron paramagnetic resonance (EPR) testing and electrochemical measurements. Ketonic CO groups, pyridinic N and pyrrolic N were responsible for non-radical pathway in SMX degradation process. Besides, Fe(II) modulated by N-doping was the main actives site for radicals generation. The contribution of active sites on catalyst surface to oxidative species formation provided fundamental basis for practical water treatment in PMS process.

5.
Adv Sci (Weinh) ; : e2103910, 2021 Nov 16.
Artigo em Inglês | MEDLINE | ID: mdl-34784102

RESUMO

Lithium-sulfur (Li-S) battery is identified as one of the most promising next-generation energy storage systems due to its ultra-high theoretical energy density up to 2600 Wh kg-1 . However, Li metal anode suffers from dramatic volume change during cycling, continuous corrosion by polysulfide electrolyte, and dendrite formation, rendering limited cycling lifespan. Considering Li metal anode as a double-edged sword that contributes to ultrahigh energy density as well as limited cycling lifespan, it is necessary to evaluate Li-based alloy as anode materials to substitute Li metal for high-performance Li-S batteries. In this contribution, the authors systematically evaluate the potential and feasibility of using Li metal or Li-based alloys to construct Li-S batteries with an actual energy density of 500 Wh kg-1 . A quantitative analysis method is proposed by evaluating the required amount of electrolyte for a targeted energy density. Based on a three-level (ideal material level, practical electrode level, and pouch cell level) analysis, highly lithiated lithium-magnesium (Li-Mg) alloy is capable to achieve 500 Wh kg-1 Li-S batteries besides Li metal. Accordingly, research on Li-Mg and other Li-based alloys are reviewed to inspire a promising pathway to realize high-energy-density and long-cycling Li-S batteries.

6.
Environ Sci Technol ; 2021 Nov 18.
Artigo em Inglês | MEDLINE | ID: mdl-34793160

RESUMO

Peroxymonosulfate (PMS)-based advanced oxidation processes (PMS-AOPs) as an efficient strategy for organic degradation are highly dependent on catalyst design and structured active sites. However, the identification of the active sites and their relationship with reaction mechanisms for organic degradation are not fully understood for a composite catalyst due to the complex structure. Herein, we developed a family of Co encapsulated in N-doped carbons (Co-PCN) with tailored types and contents of active sites via manipulated pyrolysis for PMS activation and ciprofloxacin (CIP) degradation, focusing on the correlation of active sites to generated reactive species and degradation routes of organics. The structure-function relationships between the different active sites in Co-PCN catalysts and reactive oxygen species (ROS), as well as bond breaking position of CIP, were revealed through regression analysis and density functional theory calculation. Co-Nx, O-C═O, C═O, graphitic N, and defects in Co-PCN stimulate the generation of 1O2 for oxidizing the C-C bond in the piperazine ring of CIP into C═O. The substitution of F by OH and hydroxylation of the piperazine ring might be induced by SO4•- and •OH, whose formation was affected by C-O, Co(0), Co-Nx, graphitic N, and defects. The findings provided new insights into reaction mechanisms in PMS-AOP systems and rational design of catalysts for ROS-oriented degradation of pollutants.

7.
Plant Commun ; 2(5): 100214, 2021 Sep 13.
Artigo em Inglês | MEDLINE | ID: mdl-34746760

RESUMO

Sphingolipids, which comprise membrane systems together with other lipids, are ubiquitous in cellular organisms. They show a high degree of diversity across plant species and vary in their structures, properties, and functions. Benefiting from the development of lipidomic techniques, over 300 plant sphingolipids have been identified. Generally divided into free long-chain bases (LCBs), ceramides, glycosylceramides (GlcCers) and glycosyl inositol phosphoceramides (GIPCs), plant sphingolipids exhibit organized aggregation within lipid membranes to form raft domains with sterols. Accumulating evidence has revealed that sphingolipids obey certain trafficking and distribution rules and confer unique properties to membranes. Functional studies using sphingolipid biosynthetic mutants demonstrate that sphingolipids participate in plant developmental regulation, stimulus sensing, and stress responses. Here, we present an updated metabolism/degradation map and summarize the structures of plant sphingolipids, review recent progress in understanding the functions of sphingolipids in plant development and stress responses, and review sphingolipid distribution and trafficking in plant cells. We also highlight some important challenges and issues that we may face during the process of studying sphingolipids.

8.
J Hazard Mater ; 424(Pt A): 127119, 2021 Sep 11.
Artigo em Inglês | MEDLINE | ID: mdl-34597926

RESUMO

Uranium (U) immobilization from wastewater by zero valent iron (ZVI) was widely concerned through reduction and surface adsorption. Releasing of U due to re-oxidation of U(IV) into U(VI) limited the application of ZVI in U decontamination. In this work, a kind of biochar supported nano zero valent iron (Fe/BC(900)) was obtained by carbothermal reduction of starch mixed with ferric nitrate at 900 °C. U immobilization behavior by Fe/BC(900) in the presence of phosphate (P) was investigated. The U immobilization reaction was adjusted by controlling the sequence of U, Fe/BC(900) and P. U immobilization efficiency was enhanced to 99.9% in the presence of P. Reaction sequence of U, Fe/BC(900) and P influenced the U immobilization efficiency, which followed the order of (U-P)+Fe/BC(900)>(U- Fe/BC(900))+P>U+Fe/BC(900)>(P-Fe/BC(900))+U. P and nZVI both contributed to enhancing U immobilization through precipitation of uranyl-P and reductive co-precipitate (U(IV)) in a wide pH range. The released Fe ions could precipitate with uranyl and phosphate. Consumption of P and nZVI in the (P-Fe/BC(900))+U system limited U immobilization ability. The precipitate is highly dependent on U, P and Fe elements. U desorption in (U-P)+Fe/BC(900) system was not observed with stability.

9.
Artigo em Inglês | MEDLINE | ID: mdl-34691211

RESUMO

Tanshinone IIa (TanIIa), an ingredient of Radix Salviae Miltiorrhizae, has an anticancer effect on various solid tumors with high efficiency and low toxicity. Nonetheless, the underlying role of TanIIa in acute promyelocytic leukemia (APL) remains unclear. Here, we revealed that TanIIa drastically inhibited NB4 cell viability with an IC50 value of 31.25 µmol/L. Using flow cytometry apoptosis assay, we identified that TanIIa dose-dependently exacerbated NB4 cell apoptosis. Mechanistically, TanIIa upregulated apoptotic factor levels, namely, cleaved-caspase 9, cleaved-caspase 3, and cleaved-PARP-1. Moreover, we noticed that TanIIa dose-dependently suppressed the PI3K/Akt/mTOR axis. This axis not only functions as an essential antiapoptotic modulator but also serves as a suppressant regulator of autophagy. Correspondingly, we detected the levels of autophagic marker, namely, LC3B, which were increased after the TanIIa treatment. Furthermore, the autophagy inhibitor Baf-A1 could effectively reverse the TanIIa-induced apoptosis, manifesting that TanIIa eliminated NB4 cells in an autophagy-dependent manner. In conclusion, tanshinone IIa exerts anti-APL effects through triggering autophagy and apoptosis in NB4 cells.

10.
Endocrine ; 2021 Oct 26.
Artigo em Inglês | MEDLINE | ID: mdl-34699028

RESUMO

PURPOSES: Distant metastasis from papillary thyroid microcarcinoma (PTMC) is extremely rare and the long-term outcomes and independent prognostic factors remain unclear. The present study aimed to investigate clinicopathological characteristics and evaluate the long-term outcomes and prognostic factors of PTMC patients with distant metastases (DM) who underwent surgery and radioactive iodine (131I) treatment. METHODS: We retrospectively reviewed the medical records of 13,441 patients with thyroid cancer (including 1697 cases with PTMC) who underwent 131I treatment at our institution between January 2008 and December 2019. PTMC patients with distant metastases with sufficient clinical follow-up data were enrolled in this cohort study. The overall survival (OS) and progression-free survival (PFS) were analyzed by the Kaplan-Meier method and the prognostic factors were assessed by Cox proportional hazards. RESULTS: Thirty-three PTMC patients with DM were enrolled in this study. The median follow-up was 75 months (range: 5-151 months). The 5-year and 10-year OS rates were 96.97 and 81.41%, respectively, and the 5-year and 10-year PFS rates were 90.46 and 69.68%, respectively. Multivariate analysis showed that male sex (P = 0.005), radioactive iodine refractory PTMC (P = 0.033), and symptomatic DM (P = 0.022) were significantly associated with worse 10-year PFS in PTMC patients with DM. No independent predictor related to poor 10-year OS was found in the present study. CONCLUSIONS: The prognosis of PTMC patients becomes worse after the development of DM. Male sex, radioactive iodine refractory PTMC, and symptomatic DM were identified as independent factors associated with PFS.

11.
J Hazard Mater ; 424(Pt B): 127424, 2021 Oct 03.
Artigo em Inglês | MEDLINE | ID: mdl-34634708

RESUMO

Exfoliation of carbon nitride (g-C3N4) into an ultrathin nanostructure significantly improves its photoactivity. However, the effects of the exfoliation method on the microstructure and photocatalytic performance of g-C3N4 nanosheets remain largely unknown. Herein, several typical strategies, such as thermal, chemical, ultrasonic and one-step exfoliation, were applied to exfoliate g-C3N4 nanosheets for photocatalytic applications. A procedure capable of controlling the morphology, microstructure, light-absorption property, and visible light photoactivity of g-C3N4 nanosheets was attempted. We found that nanosheets prepared from one-step exfoliation present superior photocatalytic efficiency under visible light than those fabricated by thermal exfoliation and ultrasonic exfoliation. The kinetic constants for bisphenol A (BPA) photodegradation over these samples were determined to be 6.5, 4.5 and 2.3 times higher than bulk g-C3N4, respectively. For chemical exfoliation, excessive oxidation by H2SO4 can lead to the structural defects and deactivation of urea-derived g-C3N4 nanosheets. Carbon nitride nanosheets synthesized by one-step exfoliation exhibited high specific surface area, optimal band gap energy structure, and high charge separation efficiency, thereby increasing visible-light photoactivity. Enabling cost-effective production of ultrathin and robust g-C3N4 nanosheets, one-step exfoliation offers a potential strategy to exploit high-performance g-C3N4 for water purification applications.

12.
Clin Nucl Med ; 2021 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-34661561

RESUMO

ABSTRACT: We present a 38-year-old man who underwent total thyroidectomy with radical right neck dissection due to papillary thyroid cancer was referred for 131I treatment. The patient was in subclinical hypothyroidism with remarkable stimulated Tg level after 4 weeks of L-thyroxine withdrawal before 131I treatment, which indicated hyperfunctioning metastasis. Posttherapeutic 131I whole-body scan combined with 131I SPECT/CT performed on day 3 after 131I administration revealed an elevated 131I uptake mass in cervicothoracic region. To our surprise, the mass was histologically confirmed to be a retrosternal goiter.

13.
Ying Yong Sheng Tai Xue Bao ; 32(8): 2982-2988, 2021 Aug.
Artigo em Chinês | MEDLINE | ID: mdl-34664473

RESUMO

In this study, three dominant bacteria Cellulomonas flavigena (Ⅰ), Cellulomonas flavigena (Ⅱ), Sphingomonas paucimobilis (Ⅲ) from Fire Phoenix rhizosphere soil were used to develop a multi-microbial agent system. For oil-contaminated soil in the Dagang oilfield, the immobilized test bacteria were inoculated into the Fire Phoenix rhizosphere soil to examine the effects of bacterial agents on polycyclic aromatic hydrocarbons (PAHs)-contaminated soil. The results showed that PAHs degradation was promoted under the ⅠⅢ (with an effective number of viable bacteria of 109 cfu·mL-1) and ⅠⅡⅢ (with an effective number of viable bacteria of 107 cfu·mL-1) treatments. The PAHs degradation rates were 32.2% and 41.4%, respectively, being significantly higher than that in the control treatments. The ⅠⅡⅢ treatment significantly promoted the belowground biomass of Fire Phoenix, which was 31.2% higher than that of the control treatment. Our results suggested that the multi-microbial agent constructed by the three dominant bacteria ⅠⅡⅢ could be used as a strengthening method for the remediation of PAHs-contaminated soil by Fire Phoenix, which provided a novel method for microbial enhanced phytoremediation technology.


Assuntos
Hidrocarbonetos Policíclicos Aromáticos , Poluentes do Solo , Bactérias , Cellulomonas , Hidrocarbonetos Policíclicos Aromáticos/análise , Solo , Microbiologia do Solo , Poluentes do Solo/análise , Sphingomonas
14.
Cell Death Dis ; 12(11): 1018, 2021 10 29.
Artigo em Inglês | MEDLINE | ID: mdl-34716295

RESUMO

Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, and metastasis is the major cause of the high mortality of HCC. In this study, we identified that AnnexinA7 (ANXA7) and Sorcin (SRI) are overexpressed and interacting proteins in HCC tissues and cells. In vitro functional investigations revealed that the interaction between ANXA7 and SRI regulated epithelial-mesenchymal transition (EMT), and then affected migration, invasion, and proliferation in HCC cells. Furthermore overexpression/knockdown of ANXA7 was remarkably effective in promoting/inhibiting tumorigenicity and EMT in vivo. Altogether, our study unveiled a mechanism that ANXA7 promotes EMT by interacting with SRI and further contributes to the aggressiveness in HCC, which provides a novel potential therapeutic target for preventing recurrence and metastasis in HCC.

15.
Phytochemistry ; 193: 112974, 2021 Oct 12.
Artigo em Inglês | MEDLINE | ID: mdl-34653908

RESUMO

Intestinal commensal fungi are vital to human health, and their metabolites play a key role in the reciprocal relationship. In the present work, eighteen alkaloids and seven monoterpenoids were isolated from the fermentation of the human intestinal fungus Penicillium oxalicum SL2, including seven undescribed alkaloids (penicilloxalines A-G), three undescribed monoterpenoids (penicilloxalines H-J), and fifteen reported compounds. The structures of the isolated compounds were identified by HRESIMS, 1D and 2D NMR, electronic circular dichroism spectra and quantum chemical calculations. Some metabolites displayed moderate agonistic effects against the pregnane X receptor (PXR), whereas (6R)3,7-dimethyl-6,7-dihydroxy-2(Z)-octenoic acid displayed a significant agonistic effect against the farnesoid X receptor (FXR) with an EC50 value of 0.43 µM, which was verified by investigating FXR downstream target genes and proteins, such as small heterodimer partner 1 (SHP1), fibroblast growth factor (FGF), and bile salt export pump (BSEP).

16.
Sci Total Environ ; : 151014, 2021 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-34662616

RESUMO

Sustainable and resourceful utilization of garden waste with high lignocellulosic content remains a huge challenge, anaerobic digestion (AD) and hydrothermal treatment provide prospective technologies with achieving environmental and economic benefits. In this study, a 7-28 d AD was provided as a biomass pretreatment means and combined with hydrothermal carbonization (HTC) to treat three typical garden wastes (leaves, branches, grass). The results showed that AD pretreatment could effectively change the surface composition and structure properties of the feedstocks and thus modulating the properties of the hydrochar downstream. Compared to the unpretreatment samples, the specific surface area (SSA), higher heating value (HHV), energy density and nutrient elements (P and K) of hydrochar obtained by AD pretreatment were significantly improved and enriched, respectively. Specifically, the highest HHV of hydrochar obtained from leaves, branches, and grass were 25.71, 25.63, and 23.81 MJ/kg, which obtained with 21, 14, and 7 d of AD pretreatment respectively. The P contents of hydrochar of leaves and grass pretreated with AD for 14 and 7 d were 205% and 15% higher than those without AD pretreatment, respectively. Additionally, in this coupled system, the biomass energy recovery of 90.2% (78.2% biochar and 12.0% CH4) was achieved on leaves pretreated with AD for 21 d. Energy recovery of 81.2% (66.8% biochar, 14.4% CH4) and 71.3% (39.7% biochar, 31.6% CH4) was obtained by 14 d of AD pretreatment on branches and grass, respectively. Thus, this study enhances energy utilization efficiency and reduces secondary waste generation, providing valuable new insights into AD coupled with HTC technology.

17.
Shanghai Kou Qiang Yi Xue ; 30(4): 406-409, 2021 Aug.
Artigo em Chinês | MEDLINE | ID: mdl-34693435

RESUMO

PURPOSE: To investigate the current status of oral health cognition behavior and oral health status of children, and to provide countermeasures for the prevention and treatment of oral diseases in children. METHODS: A total of 387 primary school students in the urban area of Shanghai from December 2018 to February 2019 were surveyed using Children's Oral Health Questionnaire and child oral health impact profile(COHIP). SPSS 24.0 software package was used to conduct statistical analysis of the results through descriptive, univariate and multivariate analysis. RESULTS: The cognition of oral health of children aged 6-9 years old in Shanghai urban area was generally good, but their oral health behavior was average. The caries rate of 387 children reached 57.4%, and the oral health status was not good. Correlation analysis and regression analysis showed that children's oral health behavior was positively correlated with oral health cognition(r=0.260,P<0.05), and negatively correlated with positive and negative effects of oral health status(r=-0.333,-0.181,P<0.05), while children's oral health cognition had no significant effect on their oral health status(P>0.05). CONCLUSIONS: The better the oral health behavior habits of children, the greater the positive impact on oral health status; the development of oral health education for children requires more attention to the cultivation of oral health behavior patterns.


Assuntos
Cárie Dentária , Saúde Bucal , Criança , China/epidemiologia , Cognição , Cárie Dentária/epidemiologia , Comportamentos Relacionados com a Saúde , Educação em Saúde Bucal , Humanos
18.
J Clin Lab Anal ; : e24068, 2021 Oct 26.
Artigo em Inglês | MEDLINE | ID: mdl-34699640

RESUMO

AIM: To measure and evaluate the distribution and possible contributing factors of seven bone metabolism-associated biomarkers in Tibet, a plateau province of China. METHODS: A total of 1615 individuals were recruited from Tibet at three different altitudes. The levels and possible contributing factors of serum calcium, serum phosphorus, ALP, 25OHD, PINP, CTX, and PTH were evaluated. RESULTS: In total, 1246 Tibetan adults (males: n = 543) were eventually enrolled in this study. Multiple linear regression recognized age, sex, altitude, and BMI as the major effect factors. The levels of ALP, PINP, and CTX in males continuously decreased with age; however, those in females increased after approximately 39 years of age. Males had higher 25OHD levels (23.9 vs. 15.4 ng/ml) but lower levels of serum phosphorus (1.12 vs. 1.19 mmol/L) and PTH (41.3 vs. 47.4 pg/ml) than females. Before the age of 50, males had higher levels of calcium, ALP, PINP, and CTX than females, and the opposite trend was observed after the age of 50. The highest levels of serum calcium and phosphorus and the lowest levels of PINP and CTX were found in the Shigatse/Lhasa region, suggesting a better bone metabolism status. Compared with reports from plain areas of China, significantly higher levels of PINP (65.3 vs. 49.36 ng/ml) and CTX (0.46 vs. 0.37 ng/ml) were recorded in Tibetan adults. CONCLUSION: A more active bone turnover status was found in Tibetan adults than in individuals from the plain areas of China.

19.
Anat Rec (Hoboken) ; 304(11): 2426-2435, 2021 11.
Artigo em Inglês | MEDLINE | ID: mdl-34623769

RESUMO

As a representative of acupuncture and nonpharmaceutical therapy, auricular acupuncture has been widely for the treatment of insomnia. Transcutaneous auricular vagus nerve stimulation (taVNS) is a combination of auricular point stimulation and vagus nerve stimulation. It can not only treat primary insomnia effectively, but also is noninvasive, painless, portable and economical. The medial prefrontal cortex (mPFC) is a core region of default mode network (DMN), which is important for maintenance of sleep. However, the mechanism of taVNS in alleviating primary insomnia (PI) remains to be clarified. In this study, we found that taVNS could not only effectively reduce the score of Pittsburgh Sleep Quality Index, but also decreased functional connection (FC) between the left mPFC and bilateral dorsal anterior cingulate gyrus as well as FC between the right mPFC and the occipital cortex in patients with PI. Furthermore, the decrease in FC was positively correlated with the decline of sleep index score. Therefore, we proposed that treatment with taVNS can improve sleep quality and prolong sleep duration in patients with PI by reducing FC within DMN, FC between DMN and salience network, as well as FC between DMN and the occipital cortex. This may be one of mechanisms of taVNS in treating PI.

20.
Mol Ther Oncolytics ; 22: 326-335, 2021 Sep 24.
Artigo em Inglês | MEDLINE | ID: mdl-34553022

RESUMO

Drug resistance is a key factor in the treatment failure of clinical non-small cell lung cancer (NSCLC) patients after adjuvant chemotherapy. Here, our results provide the first evidence that eukaryotic translation initiation factor 2b subunit delta (EIF2B4)-Stratifin (SFN) fusion and increased SFN expression are associated with chemotherapy tolerance and activation of the phosphatidylinositol 3 kinase/v-akt murine thymoma viral oncogene (PI3K/Akt) signaling pathway in NSCLC patients, suggesting that SFN might have potential prognostic value as a tumor biomarker for the prognosis of patients with NSCLC.

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