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1.
Chemosphere ; 286(Pt 2): 131747, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34358893

RESUMO

Pyrimidine and purine bases (adenine, cytosine, guanine and thymine) are important precursors of organic chloramines (OC) and disinfection by-products (DBPs) during chlor(am)ination. In this study, OC and DBP formation derived from pyrimidine and purine bases during chlor(am)ination, post-chlor(am)ination after pretreated by UV alone and UV/chlorination were systematically investigated with ultraviolet light-emitting diodes (UV-LEDs, 265 and 275 nm) and low pressure mercury lamp (LPUV, 254 nm). The results revealed that higher OC formation was observed during chlorination than that during chloramination of pyrimidine and purine bases. The degradation of pyrimidine and purine bases followed the pseudo-first-order kinetics. Both solution pH and UV wavelength played vital influence on the degradation of pyrimidine and purine bases. In terms of fluence-based rate constants (kobs), the degradation rates of pyrimidine and purine bases decreased in the order of 275 nm > 265 nm > 254 nm in alkaline conditions. The synergistic effects of kobs, chlorine,kobs, •OH and kobs, RCS contributed to the differences of pyrimidine and purine bases degradation at different pH values and UV wavelengths. A vital suppression of OC formation was observed during post-chlorination after pretreated by 275 nm UV-LED/chlorination. In addition, compared with LPUV (254 nm), less DBP formation was observed at UV-LED (275 nm), especially during the UV/chlorine process. The phenomena obtained in this study indicated that 275 nm UV-LED combined with chlorine could be a preferred method to promote pyrimidine and purine bases degradation and control OC and DBP formation in practical water treatment.


Assuntos
Desinfetantes , Poluentes Químicos da Água , Purificação da Água , Cloraminas , Cloro , Desinfecção , Halogenação , Purinas , Pirimidinas , Poluentes Químicos da Água/análise
2.
Complex Intell Systems ; : 1-14, 2021 Jul 27.
Artigo em Inglês | MEDLINE | ID: mdl-34777972

RESUMO

When an emergency occurs, effective decisions should be made in a limited time to reduce the casualties and economic losses as much as possible. In the past decades, emergency decision-making (EDM) has become a research hotspot and a lot of studies have been conducted for better managing emergency events under tight time constraint. However, there is a lack of a comprehensive bibliometric analysis of the literature on this topic. The objective of this paper is to provide academic community with a complete bibliometric analysis of the EDM researches to generate a global picture of developments, focus areas, and trends in the field. A total of 303 journal publications published between 2010 and 2020 were identified and analyzed using the VOSviewer in regard to cooperation network, co-citation network, and keyword co-occurrence network. The findings indicate that the annual publications in this research field have increased rapidly since 2014. Based on the cooperation network and co-citation network analyses, the most productive and influential countries, institutions, researchers, and their cooperation networks were identified. Using the co-citation network analysis, the landmark articles and the core journals in the EDM area are found out. With the help of the keyword co-occurrence network analysis, research hotspots and development of the EDM domain are determined. According to current trends and blind spots in the literature, possible directions for further investigation are finally suggested for EDM. The literature review results provide valuable information and new insights for both scholars and practitioners to grasp the current situation, hotspots and future research agenda of the EDM field.

3.
Int J Oral Implantol (Berl) ; 14(4): 435-451, 2021 Nov 02.
Artigo em Inglês | MEDLINE | ID: mdl-34726851

RESUMO

PURPOSE: To introduce a novel and efficient procedure to solve a multidisciplinary issue connected to implant-related surgery in areas near periapical lesions of adjacent teeth using single-stage combined surgery while exploring a new way to prevent retrograde peri-implantitis. MATERIALS AND METHODS: A 31-year-old woman diagnosed with a Kennedy III dentition defect in the maxillary right central incisor and posttreatment apical periodontitis in the maxillary right lateral incisor was treated using a multidisciplinary procedure. First, the preoperative data were collected from intraoral, extraoral facial and CBCT scans. Then, the aesthetic appearance of the anterior teeth was planned digitally and implant insertion was simulated. Next, virtual bone augmentation was carried out with reference to the simulated implant position, and according to the virtual augmentation, the templates for bone shell harvesting (also used for apical osteotomy and root tip resection during endodontic microsurgery) and bone shell grafting of the edentulous area were designed and fabricated. The templates for combined surgery (endodontic microsurgery and horizontal bone augmentation) consisted of one basal template and multiple interchangeable attachments via a plugin design to make guided endodontic microsurgery and digitally guided bone augmentation more efficient. Combined surgery was then carried out using the templates for guidance. During surgery, the apical inflammation affecting the maxillary right lateral incisor was first removed and its preserved apical bony window was prepared as an autogenous bone shell for bone augmentation of the maxillary right central incisor site. Guided bone regeneration of the edentulous area and guided tissue regeneration were then performed for the adjacent tooth. Six months after the combined surgery, digital guided implant surgery was carried out for the edentulous area. The final prosthesis was delivered in accordance with the preoperative aesthetic design and achieved using an implant-supported restoration for the maxillary right central incisor, full crown restoration for the maxillary right lateral incisor, and ceramic veneers for the maxillary left central and lateral incisors for space closure. RESULTS: The horizontal bone augmentation in the edentulous area and endodontic microsurgery on the neighbouring tooth were performed successfully in a single-stage surgical procedure; thus, augmentation of the resorbed alveolar bone and removal of infection in the adjacent site were achieved simultaneously. At the 1-year follow-up after combined surgery, the healing of the natural maxillary right lateral incisor and the area having undergone bone augmentation showed promising results with no postoperative complications. CONCLUSIONS: This novel digital workflow appears effective in addressing the problem of periapical lesions in retained teeth adjacent to the edentulous area that requires horizontal bone augmentation in one surgical procedure, providing an efficient way of resolving the problem using endodontics and implantology, and preventing retrograde peri-implantitis.


Assuntos
Microcirurgia , Boca Edêntula , Adulto , Feminino , Seguimentos , Humanos , Incisivo/diagnóstico por imagem , Maxila/diagnóstico por imagem
4.
BMC Cancer ; 21(1): 1185, 2021 Nov 06.
Artigo em Inglês | MEDLINE | ID: mdl-34742270

RESUMO

BACKGROUND: Various randomized trials have demonstrated that postmastectomy radiotherapy (RT) to the chest wall and comprehensive regional nodal areas improves survival in patients with axillary node-positive breast cancer. Controversy exists as to whether the internal mammary node (IMN) region is an essential component of regional nodal irradiation. Available data on the survival benefit of IMN irradiation (IMNI) are conflicting. The patient populations enrolled in previous studies were heterogeneous and most studies were conducted before modern systemic treatment and three-dimensional (3D) radiotherapy (RT) techniques were introduced. This study aims to assess the efficacy and safety of IMNI in the context of modern systemic treatment and computed tomography (CT)-based RT planning techniques. METHODS: POTENTIAL is a prospective, multicenter, open-label, parallel, phase III, randomized controlled trial investigating whether IMNI improves disease-free survival (DFS) in high-risk breast cancer with positive axillary nodes (pN+) after mastectomy. A total of 1800 patients will be randomly assigned in a 1:1 ratio to receive IMNI or not. All patients are required to receive ≥ six cycles of anthracycline and/or taxane-based chemotherapy. Randomization will be stratified by institution, tumor location (medial/central vs. other quadrants), the number of positive axillary nodes (1-3 vs. 4-9 vs. ≥10), and neoadjuvant chemotherapy (yes vs. no). Treatment will be delivered with CT-based 3D RT techniques, including 3D conformal RT, intensity-modulated RT, or volumetric modulated arc therapy. The prescribed dose is 50 Gy in 25 fractions or 43.5 Gy in 15 fractions. Tiered RT quality assurance is required. After RT, patients will be followed up at regular intervals. Oncological and toxilogical outcomes, especially cardiac toxicities, will be assessed. DISCUSSION: This trial design is intended to overcome the limitations of previous prospective studies by recruiting patients with pN+ breast cancer, using DFS as the primary endpoint, and prospectively assessing cardiac toxicities and requiring RT quality assurance. The results of this study will provide high-level evidence for elective IMNI in patients with breast cancer after mastectomy. TRIAL REGISTRATION: ClinicalTrails.gov , NCT04320979 . Registered 25 Match 2020, https://clinicaltrials.gov/ct2/show/NCT04320979.

5.
Adv Mater ; : e2103558, 2021 Oct 08.
Artigo em Inglês | MEDLINE | ID: mdl-34626027

RESUMO

Powering lithium-ion batteries (LIBs) by light-irradiation will bring a paradigm shift in energy-storage technologies. Herein, a photoaccelerated rechargeable LIB employing SnO2 /TiO2 heterojunction nanoarrays as a multifunctional anode is developed. The electron-hole pairs generated by the Lix TiO2 (x ≥ 0) under light irradiation synergistically enhance the lithiation kinetics and electrochemical reversibility of both SnO2 and TiO2 . Specifically, the electrons can quickly pour into the SnO2 and the generated Sn due to the more positive conduction band potentials (vs TiO2 ), and mean while the holes also promote the intercalation of Li+ into TiO2 by reaching charge balance. A remarkable increase in areal specific capacity is therefore achieved from 1.91 to 3.47 mAh cm-2 at 5 mA cm-2 . More impressively, there is no capacity loss even through 100 cycles, which is the best report for photorechargeable LIBs to date, owing to the strong and stable photoresponse current. This finding exhibits a feasible pathway to break the limitation in the energy density of LIBs by the efficient conversion and storage of solar energy.

6.
Front Oncol ; 11: 738318, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34604082

RESUMO

Purpose: To report patients' quality of life (QoL) at 1 year in a phase 2 randomized trial comparing partial breast irradiation (PBI) with whole-breast irradiation (WBI) after breast-conserving surgery (BCS) for breast cancer. Methods: Women aged ≥ 45 years with low-risk breast cancer after BCS were randomly assigned (1:1) to receive PBI (40 Gy in 10 fractions over 2 weeks) or WBI (43.5 Gy in 15 fractions over 3 weeks). The primary endpoint-the incidence of toxicities of grade 2 or higher-will be reported when participants complete 5 years of follow-up. QoL was assessed at baseline (T0), at the end of radiotherapy (RT) (T1), 6 months (T2) and 1 year (T3) after RT by using the EORTC QLQ-C30 and QLQ-BR23 questionnaires. We calculated the scores for all QOL subscales and differences in mean scores were compared. This study was registered at ClinicalTrials.gov (NCT03583619). Results: Between June 2017 and January 2019, 140 women were randomly assigned to receive PBI or WBI (n = 70 per group). Fifty-nine and 56 patients treated with PBI and WBI, respectively, were eligible for the QoL analysis. There were no significant differences in any subscale scores at T0, T1, T2, or T3 between the PBI and WBI arms. The scores for most QoL subscales that were influenced by RT recovered to a similar or better level relative to T0 scores within 1 year after RT, except for the scores of the dyspnea subscale. Longitudinal analysis showed that time since RT had a significant impact on physical functioning, role functioning, social functioning, fatigue, pain, dyspnea, financial difficulties, body image, and breast and arm symptoms. Conclusion: PBI using the intensity-modulated RT affords QoL comparable to that provided by WBI. Most QoL subscale scores that were influenced by RT recovered to a similar or better level relative to baseline scores within 1 year after RT.

7.
Small ; : e2103532, 2021 Oct 22.
Artigo em Inglês | MEDLINE | ID: mdl-34677911

RESUMO

Engineering oxygen vacancy and boosting Li2 O reversibility on oxides-based electrode are of significance but remains a challenge in high-power lithium-ion batteries. Herein, the heterogenous SnO2- x /Fe2 O3- y nanocrystals are demonstrated with tailorable x and y values enabled by a glucose-assisted spray combustion technique. Density functional theory calculations unveil the SnO2- x /Fe2 O3 with a maximum x value has the optimal electronic structure, the metallic Fe generated from Fe2 O3 can markedly reduce the free energy to break Li-O bonds for accelerating subsequent delithiation process of Li2 O. Consequently, the optimized SnO2- x /Fe2 O3 exhibits a remarkably enhanced electrochemical reversibility and reaction kinetics. After stabilized by reduced graphene oxide, the hybrid delivers a high reversible specific capacity of 1113 mAh g-1 with superior rate performance (474 mAh g-1 at 20 A g-1 ) and long cycle life (negligible loss after 500 cycles at 5 A g-1 ), the oxygen vacancy and microstructure are well-maintained after cycles. This work provides the possibilities for skillfully regulating oxygen vacancy and meantime enhancing Li2 O reversibility.

8.
PLoS Negl Trop Dis ; 15(10): e0009865, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34699522

RESUMO

BACKGROUND: Trichinellosis is a serious zoonotic disease distributed around the world. It is needed to develop a safe, effective and feasible anti-Trichinella vaccine for prevention and control of trichinellosis. The aim of this study was to construct a recombinant Lactobacillus plantarum encoding Trichinella spiralis inorganic pyrophosphatase (TsPPase) and investigate its immune protective effects against T. spiralis infection. METHODOLOGY/PRINCIPAL FINDINGS: The growth of recombinant L. plantarum was not affected by TsPPase/pSIP409-pgsA' plasmid, and the recombinant plasmid was inherited stably in bacteria. Western blot and immunofluorescence assay (IFA) indicated that the rTsPPase was expressed on the surface of recombinant L. plantarum. Oral vaccination with rTsPPase induced higher levels of specific serum IgG, IgG1, IgG2a and mucosal secretory IgA (sIgA) in BALB/c mice. ELISA analysis revealed that the levels of IFN-γ and IL-4 released from spleen, mesenteric lymph nodes and Peyer's patches were evidently increased at 2-4 weeks following vaccination, compared to MRS (De Man, Rogosa, Sharpe) medium control group (P < 0.05). Immunization of mice with rTsPPase exhibited a 67.18, 54.78 and 51.91% reduction of intestinal infective larvae, adult worms and muscle larvae at 24 hours post infection (hpi), 6 days post infection (dpi) and 35 dpi, respectively (P < 0.05), and the larval molting and development was significantly inhibited by 45.45% at 24 hpi, compared to the MRS group. CONCLUSIONS: TsPPase plays a crucial role in T. spiralis molting and development, oral vaccination with rTsPPase induced a significant local mucosal sIgA response and systemic Th1/Th2 immune response, and immune protection against T. spiralis infection in BALB/c mice.

9.
Front Oncol ; 11: 693704, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34646760

RESUMO

Immune checkpoint inhibitors have brought long-term survival benefit in advanced non-small cell lung cancer patients without driver gene mutations. Even after withdrawal of immunotherapy for a maximum of two years, some patients still benefit from this therapy and the reason is not fully clear. Results from several neoadjuvant trials indicated that in resectable lung cancer patients, neoadjuvant immunotherapy or chemo-immunotherapy led to major or complete pathological responses in a high proportion of tumors. Here we report a case of a brain-metastatic lung squamous cell carcinoma patient who received supratentorial tumor resection and thoracic surgery after chemo-immunotherapy, and achieved a pathological complete response (pCR) in both lesions. This case indicated that pCR can also happen in advanced-stage lung cancer patients receiving chemo-immunotherapy, which may be the reason for long-term benefit of those patients.

10.
Opt Express ; 29(15): 23582-23596, 2021 Jul 19.
Artigo em Inglês | MEDLINE | ID: mdl-34614622

RESUMO

Edge mis-figures are regarded as one of the most difficult technical issues in optical fabrication. At present, only the near straight-line edge tool influence function (TIF) can be fitted by a polynomial function, but it is difficult to unify a 2-D analytical model suitable for complex edge workpieces and various tools, due to the lack of the scientific understanding of the edge removal behavior. In this paper, a comprehensive mathematical model is proposed to reveal the mechanism of the edge effect and accurately predict the complex edge TIF. The concept of a nonlinear edge kernel is first proposed and verified that the nonlinear pressure can be characterized by convoluting the kernel with the edge contour, which can be easily adapted to complex edge cases; besides, the edge kernel obtaining algorithm is established. The linear pressure part is verified to be constrained by the moment balance formula, which occurs in universal joint tool. Besides, the basic pressure distribution is presented to compensate the pressure distortion caused by the uneven form of the tool pad. The introducing of these three parts makes the complex edge pressure modeled efficiently and matched perfectly with the FEA results. In addition, a series of TIF experiments were carried out on various complex edge workpieces and different tools, which could be well predicted by the proposed model in 2-D view.

11.
World J Clin Cases ; 9(25): 7593-7599, 2021 Sep 06.
Artigo em Inglês | MEDLINE | ID: mdl-34616831

RESUMO

BACKGROUND: Infliximab (IFX) is an anti-tumor necrosis factor alpha (TNF-α) agent that is widely used for the management of a variety of autoimmune and inflammatory diseases, including Crohn's disease (CD). As a result of its increasing administration, new complications have emerged. Hemorrhagic pericardial effusion, secondary to IFX therapy, is a rare but life-threatening complication. CASE SUMMARY: A 27-year-old man was diagnosed with CD (Montreal A2L3B1) 6 years prior. After failing to respond to mesalazine and methylprednisolone, he took the first dose of IFX 300 mg based on his weight (60 kg, dose 5 mg/kg) on December 3, 2018. He responded well to this therapy. However, on January 21, 2019, 1 wk after the third injection, he suddenly developed dyspnea, fever, and worsening weakness and was admitted to our hospital. On admission, computed tomography scan of the chest revealed a large pericardial effusion and a small right-side pleural effusion. An echocardiogram showed a large pericardial effusion and normal left ventricular function. Then successful ultrasound-guided pericardiocentesis was performed and 600 mL hemorrhagic fluid was drained. There was no evidence of infection and the concentrations of TNF-α, IFX, and anti-IFX antibody were 7.09 pg/mL (reference range < 8.1 pg/mL), < 0.4 µg/mL (> 1.0 µg/mL), and 373 ng/mL (< 30 ng/mL), respectively. As the IFX instruction manual for injection does mention pericardial effusion as a rare adverse reaction (≥ 1/10000, < 1/1000), so we discontinued the IFX. Monitoring of the patient's echocardiogram for 2 mo without IFX therapy showed no recurrence of hemorrhagic pericardial effusion. Follow-up visits and examinations every 3 to 6 mo until April 2021 showed no recurrence of CD or pericardial effusion. CONCLUSION: This is a case of hemorrhagic pericardial effusion following treatment with IFX. It is a rare but life-threatening complication of IFX. Early recognition helps prevent the occurrence of hemorrhagic pericardial effusion and minimize the impact on the natural evolution of the disease.

12.
Aust Endod J ; 2021 Oct 28.
Artigo em Inglês | MEDLINE | ID: mdl-34708907

RESUMO

The purpose of this study was to explore the effects of fibre-reinforced composites and onlay restorations on the fracture resistance of the cracked teeth. The experiments were grouped as follows: intact teeth, cracked teeth, crown; onlay; annular ribbond + onlay, laminated ribbond + onlay and fibre post + onlay; annular ribbond + crown, laminated ribbond + crown and fibre post + crown. The maximal Von Mises stress of dentin, the maximal Von Mises stress at the crack, the fracture resistance and fracture pattern under static loading were analysed by single-factor analysis of variance (ANOVA) and post-test by LSD. The annular ribbond + crown had a significant difference in fracture resistance than the crown (P < 0.05). The annular ribbond + onlay had more favourable fractures than crown in fracture pattern, and there were significant differences (P < 0.05). Compared with crown restoration, fibre-reinforced composites and onlay can improve the fracture resistance of the cracked teeth.

13.
Environ Int ; 158: 106950, 2021 Oct 27.
Artigo em Inglês | MEDLINE | ID: mdl-34715430

RESUMO

Viruses saturate environments throughout the world and play key roles in microbial food webs, yet how viral activities affect dissolved organic matter (DOM) processing in natural environments remains elusive. We established a large-scale long-term macrocosm experiment to explore viral dynamics and their potential impacts on microbial mortality and DOM quantity and quality in starved and stratified ecosystems. High viral infection dynamics and the virus-induced cell lysis (6.23-64.68% d-1) was found in the starved seawater macrocosm, which contributed to a significant transformation of microbial biomass into DOM (0.72-5.32 µg L-1 d-1). In the stratified macrocosm, a substantial amount of viral lysate DOM (2.43-17.87 µg L-1 d-1) was released into the upper riverine water, and viral lysis and DOM release (0.35-5.75 µg L-1 d-1) were reduced in the mixed water layer between riverine water and seawater. Viral lysis was stimulated at the bottom of stratified macrocosm, potentially fueled by the sinking of particulate organic carbon. Significant positive and negative associations between lytic viral production and different fluorescent DOM components were found in the starved and stratified macrocosm, indicating the potentially complex viral impacts on the production and utilization of DOM. Results also revealed the significant viral contribution to pools of both relatively higher molecular weight labile DOM and lower molecular weight recalcitrant DOM. Our study suggests that viruses have heterogeneous impact on the cycling and fate of DOM in aquatic environments.

14.
Radiother Oncol ; 164: 163-166, 2021 Oct 04.
Artigo em Inglês | MEDLINE | ID: mdl-34619235

RESUMO

We assessed the impact of different PCI fractionation schedules (30 Gy in 10 versus 15 fractions) on brain metastases-free survival (BMFS) and toxicity in stage III NSCLC. Our results suggest that 30 Gy in 10 fractions is associated with increased toxicity, while no conclusive evidence of improving BMFS was seen with this schedule.

15.
J Med Chem ; 64(20): 15170-15188, 2021 Oct 28.
Artigo em Inglês | MEDLINE | ID: mdl-34664960

RESUMO

The enhancer of zeste homologue 2 (EZH2) is the catalytic subunit of polycomb repressive complex 2 that catalyzes methylation of histone H3 lysine 27 (H3K27). Overexpression or mutation of EZH2 has been identified in hematologic malignancies and solid tumors. Based on the structure of EPZ6438 (1) and the binding model with PRC2, we designed a series of analogues aiming to improve the activities of EZH2 mutants. Structure-activity relationship (SAR) exploration at both enzymatic and cellular levels led to the discovery of inhibitor 29. In the biochemical assay, 29 inhibited EZH2 (IC50 = 26.1 nM) with high selectivity over other histone methyltransferases. It was also potent against EZH2 mutants (EZH2 Y641F, IC50 = 72.3 nM). Furthermore, it showed no apparent inhibitory activity against the human ether-á-go-go related gene (hERG) (IC50 > 30 µM). In vivo, 29 exhibited favorable pharmacokinetic properties for oral administration and showed better efficacy than 1 in both Pfeiffer and Karpas-422 cell-mediated xenograft mouse models, indicating that it might be a new potential therapeutic candidate for EZH2 mutant cancers.

17.
Org Biomol Chem ; 2021 Sep 23.
Artigo em Inglês | MEDLINE | ID: mdl-34553205

RESUMO

The Lewis acid-promoted self-condensation of 2-indolylmethanols has been revealed. On treatment with La(OTf)3, highly substituted indeno[1,2-b]indole derivatives have been synthesized by using easily accessible 2-indolylmethanols with up to 94% yields. The utility of this method is further highlighted by evaluating the initial photophysical properties of some prepared products, indicating that the protocol may have potential applications in the construction of novel fluorescent materials.

18.
IEEE Trans Cybern ; PP2021 Sep 06.
Artigo em Inglês | MEDLINE | ID: mdl-34487510

RESUMO

Failure mode and effect analysis (FMEA) is a widely used reliability management technology to evaluate the risk of potential failures in a system, product, or service. Nevertheless, the normal risk priority number (RPN) method has been extensively criticized for many deficiencies in practical applications. To overcome the drawbacks of traditional FMEA, plenty of methods have been suggested in previous studies. But majority of them evaluated the risk factors of each failure mode directly and cannot take group and individual risk attitudes into account. In this article, we put forward a new FMEA approach integrating probabilistic linguistic preference relations (PLPRs) and gained and lost dominance score (GLDS) method. The PLPRs are adopted to describe the risk evaluations of experts by pairwise comparison of failure modes. An extended GLDS method is introduced to derive the risk ranking of failure modes considering both group and individual risk attitudes. Moreover, a two-step optimization model is proposed to determine the weights of risk factors when their weighing information is unknown. Finally, a load-haul-dumper machine risk analysis case is presented to demonstrate the proposed FMEA. It is shown that the approach being proposed in this study provides a practical and effective way for risk evaluation in FMEA.

19.
Adv Drug Deliv Rev ; 178: 113967, 2021 11.
Artigo em Inglês | MEDLINE | ID: mdl-34509575

RESUMO

Graphene oxide (GO), for its unique structure with high biocompatibility and designability, is widely used in the antibacterial field. Various strategies have been designed to fabricate GO-based composites with antibacterial properties. This review summarized these strategies, divided them into three types and interpreted their antibacterial mechanisms: (i) "GO*/non-GO" type in which GO acts as the single antibacterial core, (ii) "GO*/non-GO*" type in which GO and non-GO components function synergistically as dual antibacterial cores, (iii) "GO/non-GO*" type in which non-GO acts as the single antibacterial core, while GO component plays a supportive, not a dominant role in antibiosis. Besides, the fields suiting their applications and factors influencing their antibacterial properties were analyzed. Finally, the limitations and prospects in the current researches were discussed. In summary, GO-based composites have revolutionized antibacterial strategies. This review may serve as a reference to inspire further research on GO-based antibacterial composites.

20.
Clin Trials ; 18(6): 746, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-34524050
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