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1.
J Zhejiang Univ Sci B ; 21(5): 394-399, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-32425005

RESUMO

At the end of 2019, a new form of pneumonia disease known as the corona virus disease 2019 (COVID-19) rapidly spread throughout most provinces of China, and the total global number of COVID-19 cases has surpassed 500 000 by Mar. 27, 2020 (WHO, 2020). On Jan. 30, 2020, the World Health Organization (WHO) declared COVID-19 a global health emergency (WHO, 2020). COVID-19 causes most damage to the respiratory system, leading to pneumonia or breathing difficulties. The confirmed case fatality risk (cCFR) was estimated to be 5% to 8% (Jung et al., 2020). Besides physical pain, COVID-19 also induces psychological distress, with depression, anxiety, and stress affecting the general population, quarantined population, medical staff, and patients at different levels (Kang et al., 2020; Xiang et al., 2020). Previous research on patients in isolation wards highlighted the risk of depressed mood, fear, loneliness, frustration, excessive worries, and insomnia (Abad et al., 2010).


Assuntos
Infecções por Coronavirus/psicologia , Infecções por Coronavirus/terapia , Terapia do Comportamento Dialético , Pneumonia Viral/psicologia , Pneumonia Viral/terapia , Adulto , Ansiedade/terapia , Betacoronavirus , China , Depressão/terapia , Feminino , Humanos , Pandemias , Período Pós-Parto , Gravidez , Gestantes/psicologia
2.
J Zhejiang Univ Sci B ; 21(5): 400-404, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-32425006

RESUMO

Public health crises, such as the outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) since Dec. 2019, are widely acknowledged as severe traumatic events that impose threats not only because of physical concerns but also because of the psychological distress of infected patients. We designed an internet-based integrated intervention and evaluated its efficacy on depression and anxiety symptoms in patients infected by SARS-CoV-2.


Assuntos
Ansiedade/terapia , Infecções por Coronavirus/psicologia , Depressão/terapia , Internet , Pneumonia Viral/psicologia , Autocuidado/métodos , Adulto , Betacoronavirus , Telefone Celular , China , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Atenção Plena , Pandemias , Estudos Prospectivos , Angústia Psicológica , Terapia de Relaxamento
4.
Medicine (Baltimore) ; 96(25): e7228, 2017 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-28640119

RESUMO

The present study aimed to explore the possible associations between the dorsolateral prefrontal cortex (DLPFC) metabolites and the cognitive function in first-episode schizophrenia (FES).This study included 58 patients with FES (29 males and 29 females; mean age, 22.66 ±â€Š7.64 years) recruited from the First Affiliated Hospital, College of Medicine, Zhejiang University, and 43 locally recruited healthy controls (16 males and 27 females; mean age, 23.07 ±â€Š7.49 years). The single-voxel proton magnetic resonance spectroscopy was used to measure the levels of N-acetylaspartate (NAA); complex of glutamate, glutamine, and γ-aminobutyric acid (Glx); choline-containing compounds; and myo-inositol in the DLPFC. The ratios of metabolites to creatine (Cr) were calculated. The cognitive function was assessed by Measurement and Treatment Research to Improve Cognition in Schizophrenia Consensus Cognitive Battery (MCCB). Correlation analysis was used to assess the relationships between the DLPFC metabolites and the cognitive function.Compared with the healthy controls, the patients with FES showed significantly reduced scores in each part of the MCCB, significantly reduced NAA/Cr, and significantly increased Glx/Cr in the left DLPFC. Poor performance in verbal learning and visual learning was correlated to the reduced NAA/Cr ratio in the left DLPFC.These findings suggest that a lower NAA/Cr ratio in the left DLPFC is associated with the cognitive deficits in patients with FES, and may be an early biochemical marker for the cognitive impairment in schizophrenia.


Assuntos
Disfunção Cognitiva/metabolismo , Córtex Pré-Frontal/metabolismo , Esquizofrenia/metabolismo , Psicologia do Esquizofrênico , Biomarcadores/metabolismo , Cognição/fisiologia , Disfunção Cognitiva/diagnóstico por imagem , Disfunção Cognitiva/etiologia , Feminino , Humanos , Masculino , Testes Neuropsicológicos , Córtex Pré-Frontal/diagnóstico por imagem , Espectroscopia de Prótons por Ressonância Magnética , Esquizofrenia/diagnóstico por imagem , Adulto Jovem
5.
Sci Rep ; 7: 40530, 2017 01 11.
Artigo em Inglês | MEDLINE | ID: mdl-28074937

RESUMO

This study aimed to investigate the less known activation pattern of T lymphocyte populations and immune checkpoint inhibitors on immunocytes in patients with bipolar II disorder depression (BD) or major depression (MD). A total of 23 patients with BD, 22 patients with MD, and 20 healthy controls (HCs) were recruited. The blood cell count of T lymphocyte subsets and the plasma level of cytokines (IL-2, IL-4, IL-6, IL-10, TNF-α, and IFN-γ) were selectively investigated. The expression of T-cell immunoglobulin and mucin-domain containing-3 (TIM-3), programmed cell death protein 1 (PD-1) and its ligands, PD-L1 and PD-L2, on T lymphocytes and monocytes, was detected. In results, blood proportion of cytotoxic T cells significantly decreased in BD patients than in either MD patients or HCs. The plasma level of IL-6 increased in patients with BD and MD. The expression of TIM-3 on cytotoxic T cells significantly increased, whereas the expression of PD-L2 on monocytes significantly decreased in patients with BD than in HCs. These findings extended our knowledge of the immune dysfunction in patients with affective disorders.


Assuntos
Transtorno Bipolar/sangue , Transtorno Bipolar/imunologia , Citocinas/sangue , Transtorno Depressivo Maior/sangue , Transtorno Depressivo Maior/imunologia , Subpopulações de Linfócitos T/imunologia , Adulto , Antígeno B7-H1/metabolismo , Estudos de Casos e Controles , Demografia , Feminino , Humanos , Células Matadoras Naturais/imunologia , Ativação Linfocitária/imunologia , Masculino
6.
Sci Rep ; 6: 30537, 2016 07 27.
Artigo em Inglês | MEDLINE | ID: mdl-27460201

RESUMO

The clinical and cognitive responses to repetitive transcranial magnetic stimulation (rTMS) in bipolar II depressed patients remain unclear. In this study, thirty-eight bipolar II depressed patients were randomly assigned into three groups: (i) left high-frequency (n = 12), (ii) right low-frequency (n = 13), (iii) sham stimulation (n = 13), and underwent four-week rTMS with quetiapine concomitantly. Clinical efficacy was evaluated at baseline and weekly intervals using the 17-item Hamilton Depression Rating Scale (HDRS-17) and Montgomery-Asberg Depression Rating Scale (MADRS). Cognitive functioning was assessed before and after the study with the Wisconsin Card Sorting Test (WCST), Stroop Word-Color Interference Test (Stroop), and Trail Making Test (TMT). Thirty-five patients were included in the final analysis. Overall, the mean scores of both the HDRS-17 and the MADRS significantly decreased over the 4-week trial, which did not differ among the three groups. Exploratory analyses revealed no differences in factor scores of HDRS-17s, or in response or remission rates. Scores of WCST, Stroop, or TMT did not differ across the three groups. These findings indicated active rTMS combined with quetiapine was not superior to quetiapine monotherapy in improving depressive symptoms or cognitive performance in patients with bipolar II depression.


Assuntos
Antipsicóticos/uso terapêutico , Transtorno Bipolar/terapia , Fumarato de Quetiapina/uso terapêutico , Estimulação Magnética Transcraniana/métodos , Adolescente , Adulto , Transtorno Bipolar/tratamento farmacológico , Transtorno Bipolar/psicologia , Método Duplo-Cego , Feminino , Humanos , Masculino , Resultado do Tratamento
7.
Arch Gerontol Geriatr ; 56(1): 38-43, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-22698678

RESUMO

To evaluate the psychometric properties of the Chinese Montreal Cognitive Assessment (MoCA-C) and assess cross-cultural differences in a community-based cohort residing in the Eastern China. The study included 72 patients with Alzheimer's disease (AD), 84 patients with mild cognitive impairment (MCI) and 146 cognitively normal controls. Sensitivities and specificities were calculated using the recommended cut-off scores. Receiver operator characteristic (ROC) curve analyses were performed to determine optimal sensitivity and specificity. Criterion validity, inter-rater, test-retest reliability and internal consistencies of the MoCA-C were examined, and clinical observations made. The influence of age, education level and gender on MoCA score was examined. Using the recommended cut-off score of 26, the area under the ROC (AUC) for predicting MCI groups using the MoCA-C was 0.930 (95%CI: 0.894; 0.965). The MoCA-C demonstrated 92% sensitivity and 85% specificity in screening for MCI. Cultural differences from the original MoCA affected the test response rate. The MoCA-C appears to have utility as a cognitive screen for early detection of AD and for MCI and warrants further investigation regarding its applicability in primary care settings in elderly Chinese people. It will be necessary to revise the contents of the questionnaire to account for by local characteristics.


Assuntos
Transtornos Cognitivos/diagnóstico , Comparação Transcultural , Testes Neuropsicológicos/normas , Fatores Etários , Idoso , Doença de Alzheimer/diagnóstico , Doença de Alzheimer/etnologia , Doença de Alzheimer/psicologia , China , Transtornos Cognitivos/etnologia , Transtornos Cognitivos/psicologia , Disfunção Cognitiva/diagnóstico , Disfunção Cognitiva/etiologia , Disfunção Cognitiva/psicologia , Escolaridade , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Psicometria , Reprodutibilidade dos Testes , Sensibilidade e Especificidade , Fatores Sexuais
8.
Ying Yong Sheng Tai Xue Bao ; 23(6): 1649-54, 2012 Jun.
Artigo em Chinês | MEDLINE | ID: mdl-22937656

RESUMO

Population is the most active factor affecting city development. To understand the distribution characteristics of urban population is of significance for making city policy decisions and for optimizing the layout of various urban infrastructures. In this paper, the information of the residential buildings in Shenyang urban area was extracted from the QuickBird remote sensing images, and the spatial distribution characteristics of the population within the Third-Ring Road of the City were analyzed, according to the social and economic statistics data. In 2010, the population density in different types of residential buildings within the Third-Ring Road of the City decreased in the order of high-storey block, mixed block, mixed garden, old multi-storey building, high-storey garden, multi-storey block, multi-storey garden, villa block, shanty, and villa garden. The vacancy rate of the buildings within the Third-Ring Road was more than 30%, meaning that the real estate market was seriously overstocked. Among the five Districts of Shenyang City, Shenhe District had the highest potential population density, while Tiexi District and Dadong District had a lower one. The gravity center of the City and its five Districts was also analyzed, which could provide basic information for locating commercial facilities and planning city infrastructure.


Assuntos
Planejamento de Cidades , Conservação dos Recursos Naturais/métodos , Ecossistema , Planejamento Ambiental , China , Sistemas de Informação Geográfica , Densidade Demográfica , Tecnologia de Sensoriamento Remoto , População Urbana
9.
Aust N Z J Psychiatry ; 46(3): 257-64, 2012 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-22391283

RESUMO

OBJECTIVES: To evaluate the effectiveness of repetitive transcranial magnetic stimulation (rTMS) started with citalopram in first-episode young major depressive patients. METHODS: In a 2-week double-blind study with a 2-week extended antidepressant phase, 60 first-episode young major depressive patients were randomly assigned to citalopram in combination with 2 weeks of either active or sham rTMS treatment. During the following 2 weeks, the patients continued only the citalopram treatment. The 17-item Hamilton depression rating scale (HAMD-17) and Montgomery-Asberg depression rating scale (MADRS) were used to assess the severity of depression. Moreover, the Wisconsin Card Sorting Test (WCST), Trail-Making Test (TMT), and Stroop Color-Word Test (SCWT) were used to assess executive function. RESULTS: (1) There was a significantly greater number of early improvers (a reduction of HAMD-17 score ≥ 20% within the first 2 weeks) observed in the active rTMS group compared to the sham group (57% vs. 29%, χ(2)=4.667, p=0.031). (2) There was no significant difference observed in responder rates (46% vs. 36%, χ(2)=0.295, p=0.586) or in remission rates (39% vs. 29%, χ(2)=0.319, p=0.572) between the two groups at 4 weeks. (3) There was a significant difference seen in both HAMD-17 and MADRS scores between the two groups at 2 and 4 weeks. The active rTMS group showed a significantly faster score reduction compared to the sham group at 2 weeks (HAMD-17, t=13.444, p=0.001; MADRS, t=30.123, p=0.000), which was maintained at 4 weeks on both scales (HAMD-17, t=46.915, p=0.000; MADRS, t=39.996, p=0.000). (4) The patients did not deteriorate in executive performance, and even improved in categories on WCST and completed TMT faster in the active group. CONCLUSIONS: RTMS accelerated the rapidity of the antidepressant response in first-episode young depressive patients. Our results call for future rTMS studies with larger sample sizes, high intensity of stimuli, and longer duration to draw more definitive conclusions.


Assuntos
Citalopram/uso terapêutico , Transtorno Depressivo Maior/tratamento farmacológico , Transtorno Depressivo Maior/terapia , Intervenção Médica Precoce/métodos , Estimulação Magnética Transcraniana/psicologia , Adolescente , Adulto , Antidepressivos/uso terapêutico , Terapia Combinada/métodos , Terapia Combinada/psicologia , Transtorno Depressivo Maior/diagnóstico , Transtorno Depressivo Maior/psicologia , Método Duplo-Cego , Diagnóstico Precoce , Função Executiva/efeitos dos fármacos , Função Executiva/fisiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Testes Neuropsicológicos/estatística & dados numéricos , Escalas de Graduação Psiquiátrica/estatística & dados numéricos , Estimulação Magnética Transcraniana/métodos
10.
Zhejiang Da Xue Xue Bao Yi Xue Ban ; 40(3): 286-90, 2011 May.
Artigo em Chinês | MEDLINE | ID: mdl-21671489

RESUMO

OBJECTIVE: To assess the early therapeutic and cognitive effect of repetitive transcranial magnetic stimulation (rTMS) combined with antidepressant medication in treatment of first-episode patients with major depression. METHODS: Sixty first-episode depressed inpatients aged 18-45 y, who met the DSM-IV clinical criteria for major depressive episode were randomly assigned to citalopram treatment (20 mg/d) in combination with a two-week period of either rTMS (study group)or sham procedure (control group) on left dorsal-lateral prefrontal cortex (10 Hz, 90% motor threshold). The Hamilton Depression Rating Scale (HAMD) was used to assess the severity of depression. The Wisconsin Card Sorting Test (WCST) and Continuous Performance Test (CPT) were used to assess cognitive function of depression. RESULT: The response rate was significantly greater in the study group compared to the control group after treatment (57% compared with 29%,P<0.05). The HAMD scores significantly declined after treatment in two groups, and the study group showed lower scores compared to the control group after 2 weeks (P<0.01). Neuropsychological assessments showed that there was no significant difference between the two groups except for the significant improvement in the categories on WCST in study group compared to the baseline (P<0.05) and the control group (P<0.05)after 2 weeks treatment. No serious event occurred in the patients during the rTMS study. CONCLUSION: 10 Hz rTMS enhances early effects of citalopram and improves cognitive function in first-episode major depressive patients.


Assuntos
Antidepressivos/uso terapêutico , Transtorno Depressivo Maior/terapia , Estimulação Magnética Transcraniana , Adolescente , Adulto , Citalopram/uso terapêutico , Terapia Combinada , Humanos , Pessoa de Meia-Idade , Resultado do Tratamento , Adulto Jovem
11.
Ying Yong Sheng Tai Xue Bao ; 20(5): 1140-6, 2009 May.
Artigo em Chinês | MEDLINE | ID: mdl-19803172

RESUMO

Based on the Landsat TM images of 2001 and 2006, and by using linear spectral unmixing (LSU) technique, the information of urban vegetation coverage inside the Third-Ring Road of Shenyang City was extracted, and the dynamic change of the vegetation coverage in 2001-2006 was analyzed, in combining with a land use map derived from the visual interpretation of a QuickBird image of 2006. The results showed that in 2001-2006, the urban vegetation coverage in study area changed drastically. Urban greening and the cropland encroachment caused by urban sprawl coexisted, and the vegetation gain from urban greening was larger than the vegetation loss from cropland encroachment. The vegetation coverage of road, residence, public facilities, and park and square increased with varying degrees (5%-9%), while industrial land changed little. The spatial distribution of urban greening was relatively reasonable. Though the polarization of vegetation coverage between central city and suburban still existed, this polarization had been mitigated to some extent. With the increase of the distance from city center, the vegetation coverage increased in sequence of park and square (0.8% x km(-1)) < residence (1.5% x km(-1)) < industrial land (1.7% x km(-1)) < public facilities (2.4% x km(-1)) < road (2.9% x km(-1)). The polarization of vegetation coverage in public facilities and road were still serious, suggesting that more greening programs and strict conservation efforts were needed.


Assuntos
Planejamento de Cidades , Ecossistema , Planejamento Ambiental , Árvores/crescimento & desenvolvimento , China , Poaceae/crescimento & desenvolvimento , Comunicações Via Satélite
12.
Zhonghua Yi Xue Za Zhi ; 89(10): 704-8, 2009 Mar 17.
Artigo em Chinês | MEDLINE | ID: mdl-19595068

RESUMO

OBJECTIVE: To study the nephrotoxicity tacrolimus (FK506) at the therapeutic dose the preventive effect of diltiazem (Dil), a calcium antagonist against the FK506-induced pathological changes. METHODS: 24 Sprague-Dawley male rats were randomly divided into 4 equal groups: cyclosporine A (CsA) group, undergoing treatment of CsA at the therapeutic dose after kidney transplantation (25 mg x kg(-1) x d(-1)) for 4 weeks, FK506 group treated with FK506 (0.8 mg x kg(-1) x d(-1)), FK506 + Dil group treated with FK506 (0.8 mg x kg(-1) x d(-1)) and Dil at the dose of 8 mg x kg(-1) x d(-1), and control group. Four weeks later body weight was measured and 24 h urine sample was collected. Then the rats were killed. Their kidneys underwent light and transmission electron microscopy. RESULTS: The body weight ad weight gain, and the weights of both kidney of the CsA group were all significantly lower than those of the other 3 groups (all P < 0.05), and there were not significant differences in there parameters among the other 3 groups. The serum creatinine levels of the FK506 and CsA groups were (36.0 +/- 2.6) and (34.2 +/- 4.5) micromol/L respectively, both significantly higher than those of the FK506 + Dil and control groups [(28.5 +/- 2.1) and (29.2 +/- 3.428) micromol/L respectively, all P < 0.05], however, there was no significant difference between the FK506 + Dil and control groups. The creatinine clearance rate of the FK506 and CsA groups were (0.63 +/- 0.45) and (0.58 +/- 0.39) ml x min(-1) x 100 g(-1) respectively, significantly lower than those of the FK506 + Dil and control groups [(1.55 +/- 0.91) and (1.02 +/- 0.62) mlxmin(-1) x 100 g(-1) respectively, all P < 0.05]. Pathological examination showed epithelial cell cloudy swelling and vacuolization and interstitial fibrosis in the renal tubules, mitochondria swelling and vacuolization in renal tubular epithelial cells, renal arteriole hyalinization, and foot cell conjugation glomerulus, mitochondria swelling and vacuolization in the FK506 and CsA groups, and such changes were relatively mild in the FK506 + Dil group. CONCLUSION: FK506 at renal transplantation therapeutic dose, as well as CsA, induces pathological changes in renal tissues and ultrastructural organization. Dil is able to prevent FK506-induced these pathological changes.


Assuntos
Diltiazem/uso terapêutico , Rim/efeitos dos fármacos , Rim/patologia , Tacrolimo/toxicidade , Animais , Rim/ultraestrutura , Transplante de Rim , Masculino , Ratos , Ratos Sprague-Dawley
13.
Zhonghua Yu Fang Yi Xue Za Zhi ; 43(5): 376-9, 2009 May.
Artigo em Chinês | MEDLINE | ID: mdl-19534989

RESUMO

OBJECTIVE: To assess the depression and anxious status among transferred injured survivors in Wenchuan earthquake in Sichuan province. METHODS: A total of 43 transferred injured survivors were investigated by questionnaire exploring their trauma symptoms and mental health status. RESULTS: High rates of trauma symptoms were remarkably observed in these survivors. Of all the respondents, 60% had some emotional symptoms and sleeping difficulties. About one third of respondents experienced recurrent and intrusive distressing recollection of event, 16 (37.21%) experienced nightmare, 15 (34.88%) had flashback and 7 (16.28%) of them tried to avoid relative stress. CONCLUSION: Many mental symptoms were observed in transferred injured survivors. The two major factors of mental stress were emotional symptoms and re-experience of the disaster.


Assuntos
Desastres , Terremotos , Transtornos de Estresse Pós-Traumáticos/psicologia , Sobreviventes/psicologia , Ferimentos e Lesões/psicologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estresse Psicológico , Sobreviventes/estatística & dados numéricos , Adulto Jovem
14.
Zhejiang Da Xue Xue Bao Yi Xue Ban ; 37(5): 483-6, 2008 Sep.
Artigo em Chinês | MEDLINE | ID: mdl-18925716

RESUMO

OBJECTIVE: To investigate the effects of androgen on sexually dimorphism nucleus in preoptic area (SDN-POA) and anteroventral periventricular nucleus (AVPV) before sexual differentiation of the brain in female rats. METHODS: Neonatal female SD rats (n=12) were randomly divided into two groups: androgen group and control group. Twenty-four hours after birth animals were subjected to intraperitoneal injection of 50 microl of testosterone propionate (TP,10.0 g/L) or aseptic oil as control. The rats were sacrificed 60 days after the injection and the brains were collected for crystal violet staining. LEICA Q Win system was applied in detecting the boundaries of SDN-POA and AVPV, then the volumes of SDN-POA and AVPV were calculated. RESULTS: The volumes of SDN-POA in androgen group were significantly larger than those in control group [(16.77+/-2.68) vs (8.99+/-1.42)mm(3)x10(-3), P<0.01], while the volumes of AVPV in androgen group were significantly smaller than those in control group [(9.14+/-1.16) vs (14.62+/-2.80)mm(3)x10(-3), P<0.01]. CONCLUSION: Exogenous androgen rendered before sexual differentiation in female rats results in enlargement of SDN-POA volumes and reduction of AVPV.


Assuntos
Androgênios/farmacologia , Núcleo Hipotalâmico Paraventricular/efeitos dos fármacos , Área Pré-Óptica/efeitos dos fármacos , Diferenciação Sexual , Animais , Animais Recém-Nascidos , Feminino , Núcleo Hipotalâmico Paraventricular/anatomia & histologia , Área Pré-Óptica/anatomia & histologia , Distribuição Aleatória , Ratos , Ratos Sprague-Dawley
15.
Zhejiang Da Xue Xue Bao Yi Xue Ban ; 37(5): 487-93, 2008 Sep.
Artigo em Chinês | MEDLINE | ID: mdl-18925717

RESUMO

OBJECTIVE: To compare the differences between homosexual and heterosexual men in the pattern of induced aversive emotion regulation. METHODS: Ten healthy homosexual men and 10 heterosexual men were investigated by functional magnetic resonance imaging under three types of visual sexual stimuli designed by Block. SPM2 software was used for data analysis. RESULTS: Same levels of negative emotions of homosexual men and heterosexual were induced by female-female and male-male erotic stimuli respectively. Activations of same brain regions including prefrontal gyrus, temporal gyrus, occipital gyrus and cerebellum were observed in two groups. However, there were significant differences in the side of hippocampus and precuneus. Activations of right cingulate cortex were observed in homosexual men, but not in heterosexual men. CONCLUSION: There are some differences in the patterns of aversive emotion regulation between homosexual and heterosexual men.


Assuntos
Tédio , Giro do Cíngulo/fisiologia , Heterossexualidade/psicologia , Homossexualidade Masculina/psicologia , Imagem por Ressonância Magnética , Adolescente , Adulto , Emoções/fisiologia , Humanos , Imagem por Ressonância Magnética/métodos , Masculino , Adulto Jovem
16.
Zhonghua Yu Fang Yi Xue Za Zhi ; 42(11): 798-801, 2008 Nov.
Artigo em Chinês | MEDLINE | ID: mdl-19176137

RESUMO

OBJECTIVE: To quickly assess the psychological status of the wounded who were transferred in the earthquake and their family members, as to promoting the system of psychological crisis intervention. METHODS: The triage assessment system was used to the 44 wounded and 37 family members, additionally, the Hamilton Depression Rating Scale (HAMD), and Hamilton Anxiety Rating Scale (HAMA) for related analysis were also administrated to verify the effectiveness of screening of the triage assessment system. RESULTS: Of the 79 wounded and their families in the triage assessment system, the score of emotion in the wounded group was (3.07 +/- 1.38), the score of cognition was (2.34 +/- 1.39), the score of behavior was (2.71 +/- 1.47), and the total score was (8.12 +/- 3.69); the score of emotion in the family group was (2.51 +/- 1.27), the score of cognition was (1.57 +/- 0.85), the score of behavior was (1.71 +/- 1.02), and the total score was (5.80 +/- 2.61). There were significant differences in the family and the wounded group in cognition, behavior and the total (t(cognition) = 2.853, P = 0.006; t(behavior) = 3.366, P = 0.001; t(total) = 3.116, P = 0.003). Both the depression and anxiety symptoms in the Hamilton Depression Scale (HAMD) and Hamilton Anxiety Scale (HAMA) were 11.48 +/- 7.62, 9.23 +/- 5.64, and 8.49 +/- 4.87, 9.38 +/- 7.05, respectively. In the emotion, cognition, behavior and total scores of the triage assessment system related to higher with HAMD and HAMA were r(emotion-HAMD) = 0.393, P = 0.001; r(emotion-HAMA) = 0.443, P = 0.000; r(cognition-HAMD) = 0.434, P = 0.000; r(cognition-HAMA) = 0.240, P = 0.037; r(behavior-HAMD) = 0.529, P = 0.000; r(behavior-HAMA) = 0.256, P = 0.026; r(total-HAMD) = 0.517, P = 0.000; r(total-HAMA) = 0.369, P = 0.001. CONCLUSION: The triage assessment system should be the reliable method for an assessment featured by a rapid, accurate and simple one in screening and monitoring.


Assuntos
Desastres , Terremotos , Família/psicologia , Saúde Mental , Ferimentos e Lesões/psicologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , China , Humanos , Pessoa de Meia-Idade , Modelos Psicológicos , Transporte de Pacientes , Triagem
17.
Zhonghua Yu Fang Yi Xue Za Zhi ; 42(11): 810-3, 2008 Nov.
Artigo em Chinês | MEDLINE | ID: mdl-19176140

RESUMO

OBJECTIVE: To detect the reliability and validity of the self-reporting questionnaire (SRQ-20), and to make a rapid assessment on mental health among victims in sudden crisis. METHODS: The SRQ-20 which is on appendix of the Ministry of Health adopted as "emergency psychological crisis intervention guiding principles" was administrated among 1222 victims in Wenchuan earthquake. The reliability of the questionnaire was tested by split-half coefficient and Cronbach's alpha coefficient; the validity was tested by means of principal component factor analysis. RESULTS: The self-reporting questionnaire and split-half coefficient was 0.748, each item of Cronbach's alpha in the reliability coefficient was between in 0.778 to 0.789, overall Cronbach's alpha in the reliability coefficient was 0.792. There were five main components in principal component factor analysis: lacking of power, somatization/biological symptoms, depression thought, emotions and awareness. CONCLUSION: The self-reporting questionnaire (SRQ-20) should have good reliability, and validity, and China's psychological crisis intervention in processing assessment of the mental health should be a fast, accurate and effective screening tool.


Assuntos
Desastres , Terremotos , Autoavaliação , Inquéritos e Questionários , Adolescente , Adulto , Criança , China , Feminino , Humanos , Masculino , Saúde Mental , Reprodutibilidade dos Testes
18.
Ying Yong Sheng Tai Xue Bao ; 19(12): 2673-9, 2008 Dec.
Artigo em Chinês | MEDLINE | ID: mdl-19288722

RESUMO

Based on the 1979, 1992, 2001 and 2006 satellite images, the spatial expansion information of Shenyang City was extracted by human-computer interactive method, and the temporal and spatial expansion characteristics of Shenyang City as well as their driving forces were analyzed from the aspects of growth intensity, center coordinates, compact index, fractal index, and elasticity coefficient, with the help of the statistic and analytic functions of GIS for the spatial data. The results showed that in 1979-2006, both the urban build-up area and its expansion rate in Shenyang were increased continuously, and reached the maximum in 2001-2006. The urban expansion showed obvious spatial heterogeneity, with the gravity shifted to the southwest. In the meantime, the compact index was decreasing while the fractal index was increasing, implying that the urban spatial configuration in Shenyang became more and more complex. Natural environmental factors, economic development, population growth, traffic infrastructure construction, and government policy and planning were the main driving forces of the urban expansion.


Assuntos
Planejamento de Cidades , Sistemas de Informação Geográfica , Crescimento Demográfico , China , Comunicações Via Satélite
19.
Zhonghua Yi Xue Za Zhi ; 87(32): 2235-7, 2007 Aug 28.
Artigo em Chinês | MEDLINE | ID: mdl-18001539

RESUMO

OBJECTIVE: To study the nephrotoxicity induced by first oral administration of tacrolimus (FK506) and the prevention of diltiazem (Dil). METHODS: 24 Sprague-Dawley male rats were randomly divided into 4 equal groups: control (n = 6), cyclosporine A (CsA) group (receiving CsA 25 mg.kg(-1).d(-1) so as to develop CsA-induced nephropathy model), FK506 group (receiving FK506 0.8 mg.kg(-1).d(-1), the common renal transplantation therapeutic dose, so as to develop FK506-induced nephropathy model), FK506 + Dil group (receiving CsA 0.8 mg.kg(-1).d(-1) and Dil 8 mg.kg(-1).d(-1)), and control group. Four weeks later body weight was measured, blood samples were collected to examine the creatinine, urea nitrogen, and uric acid, and urine samples were collected to examine the 24 h urine protein, uric acid, and creatinine. Then the rats were killed with their kidneys taken out to undergo histopathological examination. RESULTS: The urine creatinine levels of the CsA and FK506 groups were significantly lower than that of the control group (both P < 0.05), however, there was no significant difference in urine creatinine between the FK506 + Dil group and control group. The blood creatinine levels of both CsA and FK506 groups were significantly higher than those of the FK506 + Dil group and control group (all P < 0.05), however, there was no significant difference in blood creatinine between the FK506 + Dil group and control group. The urea nitrogen level of the CsA group was significantly higher than those of the other 3 groups (all P < 0.05). The creatinine clearance rates of the CsA and FK506 groups were both significantly lower than that of the control group (both P < 0.05), and the creatinine clearance rate of the FK506 + Dil group was between those of the FK506 group and control group, however, with significant differences with both of them. Histopathology examination showed cloudy swelling and vacuolization of the renal tubular epithelial cells in the CsA and FK506 groups. However, the pathological changes of the FK506 + Dil group were remarkably milder in comparison with these 2 groups. CONCLUSION: FK506 and CsA at the renal transplantation therapeutic dose induce nephrotoxicity. Diltiazem prevents FK506-induced nephrotoxicity.


Assuntos
Diltiazem/uso terapêutico , Nefropatias/prevenção & controle , Rim/efeitos dos fármacos , Tacrolimo/toxicidade , Animais , Creatina/sangue , Creatina/urina , Ciclosporina/toxicidade , Diltiazem/administração & dosagem , Modelos Animais de Doenças , Relação Dose-Resposta a Droga , Rim/patologia , Nefropatias/induzido quimicamente , Transplante de Rim , Masculino , Período Pós-Operatório , Distribuição Aleatória , Ratos , Ratos Sprague-Dawley
20.
Zhonghua Yu Fang Yi Xue Za Zhi ; 39(4): 237-40, 2005 Jul.
Artigo em Chinês | MEDLINE | ID: mdl-16194376

RESUMO

OBJECTIVE: To investigate the differences in level of common knowledge toward common psychiatric disorders and means of therapy in general population, resulting from different education levels and living areas. METHODS: All 4,614 persons over 15 years of age recruited from general population in Zhejiang Province via stratified randomly sampling, were classified by education levels as illiteracy, primary school level, high school level, and college level. Each group was thus divided into two categories according to the person's living areas, ie urban and rural area. The level of common knowledge about psychosis and means of therapy were measured by a questionnaire administered to all subjects. RESULTS: The rate of knowledge of neurasthenic was the highest, reaching to 71.1%, then of knowledge of schizophrenia and depression, was 47.9% and 39.3% respectively, and the rate of knowledge of alcohol dependence, mania and obsessive-compulsive disorder was lower than 20%. The rate of knowledge of the 6 common psychiatric disorders was higher in people from urban area, than from rural areas. The rate of knowledge of common psychiatric disorders was increased correspondingly to the increase of the education level among the people residing at the same living area. The main means of therapy the people selected was western medicine and psychology, reaching at 24.0% and 34.8% respectively. There were significant differences among the people with different education levels but from the same living areas, and the people with lower education levels were likely to choose the therapy of western medicine, on the other hand, the people with higher education levels were tending to choose the therapy of psychology. CONCLUSION: The popularization of the knowledge and the education about mental health should be reinforced, as to improving the knowledge about mental health, choosing a correct means of therapy to the common psychiatric disorders and promoting the mental health status of the population.


Assuntos
Transtornos Mentais/epidemiologia , Transtornos Mentais/psicologia , Aceitação pelo Paciente de Cuidados de Saúde/psicologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , China/epidemiologia , Manual Diagnóstico e Estatístico de Transtornos Mentais , Escolaridade , Feminino , Humanos , Conhecimento , Masculino , Área Carente de Assistência Médica , Pessoa de Meia-Idade , Aceitação pelo Paciente de Cuidados de Saúde/estatística & dados numéricos , População Rural/estatística & dados numéricos , Inquéritos e Questionários , População Urbana/estatística & dados numéricos , Adulto Jovem
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