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1.
PLoS One ; 18(1): e0280886, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-36693066

RESUMO

Depth completion aims to predict a dense depth map from a sparse one. Benefiting from the powerful ability of convolutional neural networks, recent depth completion methods have achieved remarkable performance. However, it is still a challenging problem to well preserve accurate depth structures, such as tiny structures and object boundaries. To tackle this problem, we propose a structure preserving network (SPNet) in this paper. Firstly, an efficient multi-scale gradient extractor (MSGE) is proposed to extract useful multi-scale gradient images, which contain rich structural information that is helpful in recovering accurate depth. The MSGE is constructed based on the proposed semi-fixed depthwise separable convolution. Meanwhile, we adopt a stable gradient MAE loss (LGMAE) to provide additional depth gradient constrain for better structure reconstruction. Moreover, a multi-level feature fusion module (MFFM) is proposed to adaptively fuse the spatial details from low-level encoder and the semantic information from high-level decoder, which will incorporate more structural details into the depth modality. As demonstrated by experiments on NYUv2 and KITTI datasets, our method outperforms some state-of-the-art methods in terms of both quantitative and quantitative evaluations.


Assuntos
Nível de Saúde , Redes Neurais de Computação , Semântica
2.
Opt Lett ; 48(2): 335-338, 2023 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-36638451

RESUMO

Tunable slow and fast light generation in a silicon-on-insulator (SOI) Fano resonator is proposed and experimentally demonstrated. The slow and fast light generation with symmetric and asymmetric coupling conditions of the Fano resonator is theoretically analyzed. Under a slightly imbalanced coupling condition, the two output ports of the Fano resonator could produce a fast light and a slow light, respectively. By utilizing the thermo-optic (TO) effect to change the phase difference of the two optical beams coupled into the resonator, the transition of fast and slow light can be realized at the fixed resonance wavelength. Experimental results show that a slow-to-fast transition (group delay from 0.852 to -1.057 ns) at one resonance wavelength, and a fast-to-slow transition (group delay from -0.22 to 0.867 ns) at another resonance wavelength are realized simultaneously by controlling the microheater to tune the phase difference.

3.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi ; 39(12): 1309-1312, 2022 Dec 10.
Artigo em Chinês | MEDLINE | ID: mdl-36453949

RESUMO

The standardized medical genetics residency training in China has started late and differed from foreign training systems with no ready-made experience for reference. Started from 2014, the development of medical genetics residency training has encountered difficulties in enrollment, poor basic knowledge, and difficulties in completing the training tasks. Through a series of teaching reforms such as to offer elective courses to undergraduates, employment of flexible and diverse teaching forms such as MOOC, provision of high simulation amniocentesis model for professional skill training, and establishment of a sound teacher training system, our institution has expanded the choice for medical students' career direction and improved the core competency of medical genetics residency trainees.


Assuntos
Genética Médica , Internato e Residência , Humanos , Feminino , Gravidez , Amniocentese , China , Simulação por Computador
4.
BJOG ; 129 Suppl 2: 70-78, 2022 11.
Artigo em Inglês | MEDLINE | ID: mdl-36485065

RESUMO

OBJECTIVE: To explore the impact of the primary treatment sequence (primary debulking surgery, PDS, versus neoadjuvant chemotherapy and interval debulking surgery, NACT-IDS) on post-relapse survival (PRS) and recurrence characteristics of recurrent epithelial ovarian cancer (REOC). DESIGN: Real-world retrospective study. SETTING: Tertiary hospitals in China. POPULATION: A total of 853 patients with REOC at International Federation of Gynaecology and Obstetrics stages IIIC-IV from September 2007 to June 2020. Overall, 377 and 476 patients received NACT-IDS and PDS, respectively. METHODS: Propensity score-based inverse probability of treatment weighting (IPTW) was performed to balance the between-group differences. MAIN OUTCOME MEASURES: Clinicopathological factors related to PRS. RESULTS: The overall median PRS was 29.3 months (95% CI 27.0-31.5 months). Multivariate analysis before and after IPTW adjustment showed that NACT-IDS and residual R1/R2 disease were independent risk factors for PRS (p < 0.05). Patients with diffuse carcinomatosis and platinum-free interval (PFI) ≤ 12 months had a significantly worse PRS (p < 0.001). Logistic regression analysis revealed that NACT-IDS was an independent risk factor for diffuse carcinomatosis (OR 1.36, 95% CI 1.01-1.82, p = 0.040) and PFI ≤ 12 months (OR 1.59, 95% CI 1.08-2.35, p = 0.019). In IPTW analysis, NACT-IDS was still significantly associated with diffuse carcinomatosis (OR 1.29, 95% CI 1.05-1.58, p = 0.015) and PFI ≤ 12 months (OR 1.90, 95% CI 1.52-2.38, p < 0.001). CONCLUSIONS: The primary treatment sequence may affect the PRS of patients with REOC by altering the recurrence pattern and PFI duration.


Assuntos
Neoplasias Ovarianas , Humanos , Feminino , Carcinoma Epitelial do Ovário/patologia , Estudos Retrospectivos , Neoplasias Ovarianas/cirurgia , Neoplasias Ovarianas/tratamento farmacológico , Quimioterapia Adjuvante , Estadiamento de Neoplasias , Recidiva Local de Neoplasia/patologia , Procedimentos Cirúrgicos de Citorredução , Neoplasia Residual
5.
BJOG ; 129 Suppl 2: 60-69, 2022 11.
Artigo em Inglês | MEDLINE | ID: mdl-36485066

RESUMO

OBJECTIVE: To produce high-quality, real-world evidence for oncologists by collating scattered gynaecologic oncology (GO) medical records in China. DESIGN: Retrospective study. SETTING: The National Union of Real-world Gynaecological Oncology Research and Patient Management Platform (NUWA platform). SAMPLE: Patient-centred data pool. METHODS: The NUWA platform integrated inpatient/outpatient clinical, gene and follow-up data. Data of 11 456 patients with ovarian cancer (OC) were collected and processed using 91 345 electronic medical records. Structured and unstructured data were de-identified and re-collated into a patient-centred data pool using a predefined GO data model by technology-aided abstraction. MAIN OUTCOME MEASURES: Recent treatment pattern shifts towards precision medicine for OC in China. RESULTS: Thirteen first-tier hospitals across China participated in the NUWA platform up to 7 December 2021. In total, 3504 (30.59%) patients were followed up by a stand-alone patient management centre. The percentage of patients undergoing breast cancer gene (BRCA) mutation tests increased by approximately six-fold between 2017 and 2018. A similar trend was observed in the administration rate of poly(ADP-ribose) polymerase inhibitors as first-line treatment and second-line treatment after September 2018, when olaparib was approved for clinical use in China. CONCLUSION: The NUWA platform has great potential to facilitate clinical studies and support drug development, regulatory reviews and healthcare decision-making.


Assuntos
Neoplasias Ovarianas , Feminino , Humanos , Estudos Retrospectivos , Inibidores de Poli(ADP-Ribose) Polimerases/uso terapêutico , Neoplasias Ovarianas/tratamento farmacológico , Neoplasias Ovarianas/genética , China
6.
7.
Artigo em Inglês | MEDLINE | ID: mdl-36495242

RESUMO

BACKGROUND: We investigate the pain relief and safety of microwave ablation (MWA) combined with percutaneous vertebroplasty (PVP) in the treatment of metastatic vertebral tumors. METHODS: This prospective pilot study enrolled patients with metastatic vertebral tumors treated between January 2018 and October 2019. The participants were randomized to the PVP and MWA + PVP groups. Clinical parameters, pain visual analog scale (VAS), analgesic use scores (AUS), and quality-of-life score (QLS) were compared between groups. RESULTS: Sixty-seven participants were enrolled (PVP: n = 35; MWA + PVP: n = 32). There were no differences in bone cement injection volume, extravasation, and X-ray exposure time between the two groups (p > 0.05), but treatment costs were higher for the MWA + PVP group (26,418 ± 194 vs. 15,606 ± 148 yuan; p < 0.05). There were no significant improvements in VAS from baseline to 24 hours, 72 hours, 7 days, 1 month, and 3 months in the two groups (p > 0.05); at 6 and 12 months after the operation, the improvement from baseline was significant in the two groups (p < 0.05). The VAS was lower at 6 months (2.7 ± 0.7 vs. 3.2 ± 0.7) and 12 months (3.5 ± 0.8 vs. 4.0 ± 0.7) in the MWA + PVP group (both p < 0.01 vs. PVP). The AUS and QLS were improved with PVP at 6 and 12 months (p < 0.05) and with MWA + PVP at 12 months (p < 0.05). The AUS was lower at 6 and 12 months in the MWA + PVP group (p < 0.05 vs. PVP). CONCLUSION: MWA combined with PVP might be a safe and effective palliative treatment for pain from metastatic vertebral tumors.

9.
Sci Total Environ ; 859(Pt 1): 160215, 2022 Nov 15.
Artigo em Inglês | MEDLINE | ID: mdl-36400292

RESUMO

Determining biodiversity responses to environmental change, such as acidification, is critical for ecosystem projections under future global change scenarios. Here, we analyzed three plankton communities of phytoplankton, crustaceans and rotifers in 28 lakes in the Adirondack Park, USA, during 1994-2012, and examined the spatiotemporal trends in their alpha and beta diversity during recovery from acidification. For all plankton assemblages, Shannon diversity increased towards recent years and high lake pH, and there was an increasing community dissimilarity with pH changes. The spatial mean Bray-Curtis dissimilarities across all lakes decreased over time for phytoplankton and rotifers leading to an increase in spatial homogenization. Such a homogenization cooccurred however with the overall increasing diversity in this region, which contrasts with the previous classic view that homogenization is mainly driven by loss of species and results in biodiversity loss. We further observed lower temporal mean beta diversity in low-pH lakes for crustaceans and rotifers, but not for phytoplankton. Generally, spatial and temporal mean beta diversity of the three taxonomic groups were primarily driven by lake-water ion variables, and rotifers were also constrained by nutrients and climate. Collectively, our results show how and why plankton community compositions vary over space along with acidification recovery, and further highlight the importance of spatiotemporal studies combined with long-term monitoring programs in assessing biodiversity change during the recovery of disturbed ecosystems.

10.
Adv Mater ; : e2208942, 2022 Nov 09.
Artigo em Inglês | MEDLINE | ID: mdl-36349885

RESUMO

As key parameters of electrocatalysts, the density and utilization of active sites determine the electrocatalytic performance towards oxygen reduction reaction. Unfortunately, prevalent oxygen electrocatalysts fail to maximize the utilization of active sites due to inappropriate nanostructural design. Herein, a nano-emulsion induced polymerization self-assembly strategy is employed to prepare hierarchical meso-/microporous N/S co-doped carbon nanocage with atomically dispersed Fe-N4 (denoted as Meso/Micro-FeNSC). In-situ scanning electrochemical microscopy technology reveals the density of available active sites for Meso/Micro-FeNSC reaches to 3.57×1014 sites cm-2 , representing more than three-fold improvement compared to micropore-dominant Micro-FeNSC counterpart (1.07×1014 sites cm-2 ). Additionally, the turnover frequency of Meso/Micro-FeNSC is also improved to 0.69 from 0.50 e- site-1 s-1 for Micro-FeNSC. These properties motivate Meso/Micro-FeNSC as efficient oxygen electroreduction electrocatalyst, in terms of outstanding half-wave potential (0.91 V), remarkable kinetic mass specific activity (68.65 A g-1 ) and excellent robustness. The assembled Zn-air batteries with Meso/Micro-FeNSC deliver high peak power density (264.34 mW cm-2 ), large specific capacity (814.09 mA h g-1 ) and long cycle life (> 200 h). This work sheds lights on quantifying active site density and the significance of maximum utilization of active sites for rational design of advanced catalysts. This article is protected by copyright. All rights reserved.

11.
Biol Trace Elem Res ; 2022 Nov 05.
Artigo em Inglês | MEDLINE | ID: mdl-36333559

RESUMO

Chronic arsenic poisoning is a global health problem that affects millions of people, and studies have found that long-term ingestion of arsenic-containing compounds can lead to lung damage, but the exact mechanism is unknown. In this study, Sprague-Dawley (SD) rats were used as the research object, and the proteomic analysis method based on sequential window acquisition of all theoretical fragment ions (SWATH) was used to detect the changes in the expression levels of related proteins in the lung tissue of arsenic-exposed rats, and to explore the mechanism of arsenic compound-induced lung injury. The results showed that arsenic exposure resulted in the abnormal expression of collagen type III and proteins involved in metabolic, immune, and cellular processes, leading to the dysfunction of important pathways associated with these proteins, resulting in lung injury. It suggested that the underlying mechanism of arsenic-induced lung injury may be related to oxidative stress, immune injury, cell junction, and collagen type III. This result provides a new research idea for revealing the mechanism of lung injury caused by arsenic exposure.

12.
Neural Netw ; 157: 176-192, 2022 Oct 21.
Artigo em Inglês | MEDLINE | ID: mdl-36334538

RESUMO

Pairwise learning usually refers to the learning problem that works with pairs of training samples, such as ranking, similarity and metric learning, and AUC maximization. To overcome the challenge of pairwise learning in the large scale computation, this paper introduces Nyström sampling approach to the coefficient-based regularized pairwise algorithm in the context of kernel networks. Our theorems establish that the obtained Nyström estimator achieves the minimax error over all estimators using the whole data provided that the subsampling level is not too small. We derive the function relation between the subsampling level and regularization parameter that guarantees computation cost reduction and asymptotic behaviors' optimality simultaneously. The Nyström coefficient-based pairwise learning method does not require the kernel to be symmetric or positive semi-definite, which provides more flexibility and adaptivity in the learning process. We apply the method to the bipartite ranking problem, which improves the state-of-the-art theoretical results in previous works. By developing probability inequalities for U-statistics on Hilbert-Schmidt operators, we provide new mathematical tools for handling pairs of examples involved in pairwise learning.

13.
Vet Res Forum ; 13(3): 339-347, 2022 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-36320309

RESUMO

Porcine circovirus type 2 (PCV2) widely exists in swine production systems causing porcine circovirus diseases (PCVD) which is associated with significant economic losses. Polygonum hydropiper L. was used as a traditional Chinese medicine to treat a variety of diseases. This study was carried out to investigate anti-inflammatory activity of the ethyl acetate fraction of flavonoids from Polygonum hydropiper L. (FEA) in PCV2-induced porcine alveolar macrophages (3D4/2 cell line). The production of oxygen species (ROS) and the levels of tumor necrosis factor-α (TNF-α), interleukin-1ß (IL-1ß) and interleukin-8 (IL-8) were detected to evaluate the anti-inflammatory activities of FEA. The translocation of nuclear factor-kappa B (NF-κB) and the phosphatidylinositol 3 kinase/protein kinase B (PI3K/Akt) signaling pathways were investigated to document the potential anti-inflammatory mechanisms. In PCV2 induced 3D4/2 cells, FEA treatment significantly reduced the production of ROS, and sharply down-regulated the levels of TNF-α, IL-1ß and IL-8 in both secretion and mRNA expression level. The FEA also decreased the mRNA expression of Akt and NF-κB p65, reduced the transfer of p65 to nuclear, and inhibited the activation of PI3K/Akt signaling pathway. The findings suggest that FEA exhibited an anti-inflammatory activity in vitro and could be used as a candidate in treatment of inflammation induced by PCV2 infection.

14.
Front Mol Neurosci ; 15: 1020098, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36438183

RESUMO

Reconsolidation of heroin-associated memory is an independent memory process that occurs following retrieval, which is essential for the sustained capacity of an associative drug stimulus to precipitate heroin-seeking. Extracellular signal-regulated kinase (ERK) in the basolateral amygdala (BLA) mediates the reconsolidation of drug memory. In the present study, we utilized a rat model of drug craving and relapse to verify the hypothesis that the reconsolidation of heroin-associated memory requires ERK in an instrumental heroin-seeking behavior, focusing on the BLA brain region, which is crucial for synaptic plasticity and memory processes. We found that bilateral intra-BLA infusions of U0126 (1 µg/0.5 µl), an ERK inhibitor, immediately after retrieving heroin-associated memory significantly reduced cue-induced and drug-induced reinstatement and spontaneous recovery of heroin-seeking compared to the vehicle. Furthermore, this inhibitory effect was related to the characteristic of reconsolidation. Conversely, no effect was observed on the heroin-seeking behavior when the intra-BLA infusion of U0126 was administered 6 h after the heroin-associated memory retrieval or without memory retrieval. Together, these data suggest that disrupting the reconsolidation of heroin-associated memory via an ERK inhibitor may serve as a promising option for treating relapse in opiate addicts.

15.
Sensors (Basel) ; 22(22)2022 Nov 08.
Artigo em Inglês | MEDLINE | ID: mdl-36433203

RESUMO

Pulse measurements made using wearable devices can aid the monitoring of human physiological condition. Accurate estimation of waveforms is often difficult for nonexperts; motion artifacts may occur during tonometry measurements when the skin-sensor contact pressure is insufficient. An alternative approach is to extract only high-quality pulses for use in index calculations. The present study aimed to determine the effectiveness of using machine-learning analysis in discriminating between high-quality and low-quality pulse waveforms induced by applying different contact pressures. Radial blood pressure waveform (BPW) signals were measured noninvasively in healthy young subjects using a strain-gauge transducer. One-minute-long trains of pulse data were measured when applying the appropriate contact pressure (67.80 ± 1.55 mmHg) and a higher contact pressure (151.80 ± 3.19 mmHg). Eight machine-learning algorithms were employed to evaluate the following 40 harmonic pulse indices: amplitude proportions and their coefficients of variation and phase angles and their standard deviations. Significant differences were noted in BPW indices between applying appropriate and higher skin-surface contact pressures. The present appropriate contact pressure could not only provide a suitable holding force for the wearable device but also helped to maintain the physiological stability of the underlying tissues. Machine-learning analysis provides an effective method for distinguishing between the high-quality and low-quality pulses with excellent discrimination performance (leave-one-subject-out test: random-forest AUC = 0.96). This approach will aid the development of an automatic screening method for waveform quality and thereby improve the noninvasive acquisition reliability. Other possible interfering factors in practical applications can also be systematically studied using a similar procedure.


Assuntos
Aprendizado de Máquina , Artéria Radial , Humanos , Pressão Sanguínea/fisiologia , Reprodutibilidade dos Testes , Frequência Cardíaca , Artéria Radial/fisiologia
16.
Opt Express ; 30(14): 24852-24861, 2022 Jul 04.
Artigo em Inglês | MEDLINE | ID: mdl-36237029

RESUMO

We experimentally demonstrate a polarization-insensitive optical filter (PIOF) using polarization rotator-splitters (PRSs) and microring resonators (MRRs) on the silicon-on-insulator (SOI) platform with complementary metal-oxide-semiconductor (CMOS) compatible fabrication process. The PRS consists of a tapered-rib waveguide and an asymmetrical directional coupler (ADC), which realize the polarization rotation and splitting, to ensure the connected MRRs-based optical filter operating at one desired polarization when light with different polarizations are launched into the device. The measured results show that the optical transmission spectra of the device are identical for TE and TM polarization input. The box-like filtering spectra are also achieved with a 3-dB bandwidth of ∼0.15 nm and a high extinction ratio (ER) over 30 dB.

17.
Bioorg Med Chem Lett ; 76: 129020, 2022 11 15.
Artigo em Inglês | MEDLINE | ID: mdl-36216031

RESUMO

In order to find high-efficiency and low-toxic anti-tumor drugs, 29 pyrido[3,4-d]pyrimidine compounds were designed, synthesized and evaluated by MTT assay in vitro. The results presented that most of the compounds had good antitumor activities, among which compound 30 had the best anti-tumor activity on MGC803 cells (IC50 = 0.59 µM). Mechanistic studies exhibited that compound 30 inhibited migration of MGC803 and induced apoptosis. It was proved that compound 30 up-regulated expression of Bid and PARP, down-regulated expression of CycD1 by western blot experiments. This study indicated that compound 30 might be served as a lead agent for the treatment of human gastric cancers.


Assuntos
Antineoplásicos , Apoptose , Pirimidinas , Humanos , Antineoplásicos/síntese química , Antineoplásicos/farmacologia , Pirimidinas/síntese química , Pirimidinas/farmacologia , Relação Estrutura-Atividade , Poli(ADP-Ribose) Polimerases/metabolismo , Proteína Agonista de Morte Celular de Domínio Interatuante com BH3/metabolismo , Apoptose/efeitos dos fármacos , Linhagem Celular Tumoral
18.
Sci Rep ; 12(1): 17284, 2022 Oct 14.
Artigo em Inglês | MEDLINE | ID: mdl-36241678

RESUMO

Plasmodium knowlesi infections in Malaysia are a new threat to public health and to the national efforts on malaria elimination. In the Kapit division of Sarawak, Malaysian Borneo, two divergent P. knowlesi subpopulations (termed Cluster 1 and Cluster 2) infect humans and are associated with long-tailed macaque and pig-tailed macaque hosts, respectively. It has been suggested that forest-associated activities and environmental modifications trigger the increasing number of knowlesi malaria cases. Since there is a steady increase of P. knowlesi infections over the past decades in Sarawak, particularly in the Kapit division, we aimed to identify hotspots of knowlesi malaria cases and their association with forest activities at a geographical scale using the Geographic Information System (GIS) tool. A total of 1064 P. knowlesi infections from 2014 to 2019 in the Kapit and Song districts of the Kapit division were studied. Overall demographic data showed that males and those aged between 18 and 64 years old were the most frequently infected (64%), and 35% of infections involved farming activities. Thirty-nine percent of Cluster 1 infections were mainly related to farming surrounding residential areas while 40% of Cluster 2 infections were associated with activities in the deep forest. Average Nearest Neighbour (ANN) analysis showed that humans infected with both P. knowlesi subpopulations exhibited a clustering distribution pattern of infection. The Kernel Density Analysis (KDA) indicated that the hotspot of infections surrounding Kapit and Song towns were classified as high-risk areas for zoonotic malaria transmission. This study provides useful information for staff of the Sarawak State Vector-Borne Disease Control Programme in their efforts to control and prevent zoonotic malaria.


Assuntos
Malária , Plasmodium knowlesi , Adolescente , Adulto , Animais , Bornéu , Humanos , Macaca fascicularis , Malária/epidemiologia , Malásia/epidemiologia , Masculino , Pessoa de Meia-Idade , Adulto Jovem
20.
Front Pharmacol ; 13: 994821, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36188611

RESUMO

Moxifloxacin is the most widely prescribed antibiotics due to its excellent oral bioavailability and broad-spectrum antibacterial effect. Despite of its popularity, the rare and severe liver injury induced by moxifloxacin is a big concern that cannot be ignored in clinical practice. However, the early warning and related metabolic disturbances of moxifloxacin induced hepatoxicity were rarely reported. In this study, the dose- and time-dependent manners of moxifloxacin induced liver injury were investigated by a targeted metabolomics method. In dose-dependent experiment, three different dosages of moxifloxacin were administered to the rats, including 36 mg kg-1 d-1, 72 mg kg-1 d-1, and 108 mg kg-1 d-1. In time-dependent experiment, moxifloxacin was orally administered to the rats for 3, 7 or 14 consecutive days. Pathological analysis showed that moxifloxacin caused obvious transient hepatotoxicity, with the most serious liver injury occurred in the 7 days continuous administration group. The transient liver injury can be automatically restored over time. Serum levels of liver function related biochemical indicators, including ALT, AST, TBIL, alkaline phosphatase, superoxide dismutase, and malondialdehyde, were also measured for the evaluation of liver injury. However, these indicators can hardly be used for the early warning of hepatotoxicity caused by moxifloxacin due to their limited sensitivity and significant hysteresis. Targeted metabolomics study demonstrated that serum concentrations of fatty acyl carnitines, fatty acids and dehydroepiandrosterone can change dynamically with the severity of moxifloxacin related liver injury. The elevated serum levels of fatty acyl carnitine, fatty acid and dehydroepiandrosterone were promising in predicting the hepatotoxicity induced by moxifloxacin.

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