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1.
Biomed Pharmacother ; 121: 109425, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31726370

RESUMO

Gastric carcinoma (GC) is still one of the most common digestive system neoplasms and the primary reason for malignant cancer-associated death. Long non-coding RNAs (lncRNAs) have been reported to play critical roles in GC progression. In this study, we demonstrated that lncRNA testis development-related gene 1 (TDRG1) is markedly upregulated in clinical GC tissues and GC cells. High level of lncRNA TDRG1 correlates with the metastasis and prognosis of patients with GC. Overexpression of lncRNA TDRG1 promotes GC growth and metastatic-related traits in vitro and in vivo, and silencing TDRG1 causes opposite results. We future find that TDRG1 is inversely associated with miR-873-5p and positively modulates the expression of hepatoma-derived growth factor (HDGF), a functional target gene of miR-873-5p. Finally, lncRNA TDRG1 regulates the progression of GC through regulating miR-873-5p/HDGF pathway. Taken together, our data uncover the crucial function of TDRG1-miR-873-5p-HDGF axis in human gastric cancer.

2.
Endocrine ; 2019 Nov 30.
Artigo em Inglês | MEDLINE | ID: mdl-31786774

RESUMO

PURPOSE: Serum complement C3 has been shown to contribute to the incidence of type 2 diabetes (T2D), but how serum complement C3 affects islet ß-cell function throughout the course of T2D is unclear. This study explored whether serum complement C3 is independently associated with changes in islet ß-cell function over time in patients with T2D. METHODS: Serum complement C3 was measured, and endogenous ß-cell function was evaluated by area under the C-peptide curve (AUCcp) during an oral glucose tolerance test (OGTT) in 411 patients with T2D at baseline from 2011 to 2015. Next, 347 of those patients with available data were pooled for a final follow-up analysis from 2014 to 2018. Changes in islet ß-cell function at follow-up were evaluated by AUCcp percentage changes (ΔAUCcp%). In addition, other possible clinical risks for diabetes were also examined. RESULTS: The 347 patients included in the analysis had a diabetes duration of 4.84 ± 3.63 years at baseline. Baseline serum complement C3 (baseline C3) levels were positively correlated with baseline natural logarithm of AUCcp (lnAUCcp) (n = 347, r = 0.288, p < 0.001), and baseline C3 was independently associated with baseline lnAUCcp (ß = 0.17, t = 3.52, p < 0.001) after adjustment for baseline glycemic status and other clinical confounders by multivariate liner regression analysis. Compared with the baseline values, complement C3 changes (ΔC3) and ΔAUCcp% was -0.15 ± 0.28 mg/ml and -17.2 ± 18.4%, respectively, at a follow-up visit 4.57 ± 0.78 years later. Moreover, ΔC3 was positively correlated with ΔAUCcp% (n = 347, r = 0.302, p < 0.001). Furthermore, each 0.1 mg/ml increase in ΔC3 was associated with a higher ΔAUCcp% (1.41% [95% CI, 0.82-2.00%]) after adjusting for changes in glycemic status and other clinical confounders at follow-up. CONCLUSIONS: In addition to serum complement C3 being independently associated with islet ß-cell function at baseline, its changes were also independently associated with changes in islet ß-cell function over time in patients with T2D.

3.
Pathol Res Pract ; : 152690, 2019 Oct 12.
Artigo em Inglês | MEDLINE | ID: mdl-31735321

RESUMO

Non-small cell lung cancer (NSCLC) accounts for more than 80% of lung cancer cases with a low 5-year survival rate. MicroRNA may be targeted in the clinical treatment of the disease. In this study, miR-107 showed low expression in NSCLC serum samples, and it could suppress cell proliferation, migration and arrest cell cycle in NSCLC cell lines. Results revealed that miR-107 could inhibit the expression of transforming growth factor ß receptor 2 (TGFßR2) via targeting TGFßR2. Downregulation of TGFßR2 also suppressed cell proliferation, migration and cell cycle in NSCLC cell lines. Our data suggested that miR-107 could inhibit the progression of NSCLC by targeting TGFßR2.

4.
Math Biosci Eng ; 17(1): 845-861, 2019 Nov 05.
Artigo em Inglês | MEDLINE | ID: mdl-31731381

RESUMO

Unmanned surface vehicles (USV) is the development trend of future ships, and it will be widely used in various kinds of marine tasks. Obstacle avoidance is one key technology for autonomous navigation of USV. Convolutional neural network based obstacle classification and detection method is applied to USV visual images in environment sensing task. To solve the problem of low detection and classification accuracy of obstacles in the visual inspection of USV, a bidirectional feature pyramid networks is proposed combining hybrid network architecture of ResNet and improved DenseNet. The proposed method can further enhance the detection and classification some types of obstacles by using the underlying multi-layer detail features and high-level strong semantic features in the network architecture. The detection and classification performance of the proposed method is evaluated on a self built dataset. Ablation experiments and performance tests on open datasets are also employed. The experimental results show that the proposed algorithm has best performance for obstacles detection, and it is more suitable for autonomous navigation of USV.

5.
EBioMedicine ; 49: 189-201, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31669222

RESUMO

BACKGROUND: Sunitinib is one of the multi-targeted tyrosine kinase inhibitors for the treatment of renal cell carcinoma (RCC) at present. However, its clinical efficacy is limited by chemoresistance of RCC. Our previous study found that eukaryotic translation initiation factor 3 subunit D (EIF3D) was an oncogene in the development and progression of RCC but little is known about whether EIF3D participated in sunitinib resistance of RCC. METHODS: The expression of EIF3D in the tumor tissue specimen was detected by immunohistochemistry. The effect of EIF3D on sunitinib-resistance of RCC cells was evaluated by colony formation, IC50 proliferation and in vivo tumor growth assays. The interaction between EIF3D and glucose regulated protein 78 (GRP78) was assessed by Co-IP and Western blot assays. FINDING: EIF3D expression was found higher in 786-OR and ACHN-R cells with acquired sunitinib resistance than that in 786-O and ACHN cells sunitinib to sensitive. The EIF3D level was also up-regulated in sunitinib-chemoresistant tumor tissues compared with chemosensitive tumor tissues. Functional study showed that EIF3D knockdown decreased cell viability with sunitinib treatment. Mechanistical study demonstrated that EIF3D interacted with GRP78 and enhanced protein stability through blocking the ubiquitin-mediated-proteasome degradation of GRP78. GRP78 overexpression induced sunitinib resistance of RCC cells by triggering the unfolded protein response, whereas GRP78 silencing inhibited cell viability. Forced expression of GRP78 eliminated the inhibitory effect of EIF3D silencing on cell growth in vitro and in vivo. INTERPRETATION: our results indicate that EIF3D played an important role in sunitinib resistance of RCC cells, suggesting that it may prove to be a potential therapeutic target for RCC.

6.
Artigo em Inglês | MEDLINE | ID: mdl-31701419

RESUMO

Based on the planktonic data monitored in Lake Balihe, an ecosystem health assessment system referring to planktonic index of biotic integrity (P-IBI) was constructed to evaluate the lake health status and study the response mechanism of P-IBI to environmental factors. The results showed that a total of 7 phylum 59 species of phytoplankton and 3 phylum 28 species of zooplankton were identified in the lake, and both the plankton density and biomass varied significantly in time and space scales. The significant variation of Protozoa density should be responsible to the inconsistency between the distributions of zooplankton density and biomass, as well as the lowest value of P-IBI in summer. The P-IBI values and therefore the health levels can be seasonally ranked as winter > autumn > spring > summer and found spatially increased along the flow direction. Based on the relationships between P-IBI and the environmental factors, ammonia nitrogen = 0.46 mg/L and Secchi depth = 63 cm were found as the environmental protection thresholds of planktonic biotic integrity for this freshwater lake ecosystem. The findings of the research may provide some guidance to the ecological monitoring and protection of freshwater lake.

7.
Chem Commun (Camb) ; 55(93): 13987-13990, 2019 Nov 19.
Artigo em Inglês | MEDLINE | ID: mdl-31687673

RESUMO

Polyprodrug-based delivery technique is a fast-growing and effective strategy to improve the therapeutic efficacy of small molecule drugs. We herein developed a robust mitoxantrone (MTO)-based polyprodrug nanoplatform for systemic cisplatin prodrug delivery and combination cancer therapy. Our results show that this nanoplatform can concurrently transport MTO and cisplatin to tumor cells and significantly inhibit tumor growth.

8.
Artigo em Inglês | MEDLINE | ID: mdl-31724844

RESUMO

Up to now, the rising edge of the upconversion process does not receive due attention. Herein, a demonstration utilizing the feature of the rising edge to practically detect the linear-velocity of an object is presented. Typically, upconversion processes with different numbers of participant photons would exhibit diversity in the rising edge. On this account, when the emitter is moving, the emission intensity ratio of different multiphoton processes will vary with changing linear-velocity, which enables accurate speed detection through spectral analysis. To illustrate this principle, in this work, the modeling and numerical simulation were first performed, and then experimental demonstration was carried out in which core-shell upconversion nanocrystals were elaborately designed and fabricated as the speed sensing probe to calibrate the speed of a homemade turnplate. It is believed that the present work will exploit a novel speed sensing method and find a new application for lanthanide-doped upconversion materials.

9.
Mol Pharm ; 2019 Nov 25.
Artigo em Inglês | MEDLINE | ID: mdl-31765158

RESUMO

Eukaryotic translation initiation factors 3i (eIF3i) is a proto-oncogene that is overexpressed in various tumors, reducing its expression by eIF3i shRNA is a promising strategy to inhibit tumor growth or metastasis. Tumor cell is the target of eIF3i shRNA so that tumor-site accumulation could be important for fulfilling its therapeutic effect. Thus, the iRGD modified liposome (R-LP) was rational synthesized to enhance the anti-tumor effect by active targeted delivery of eIF3i shRNA to B16F10 melanoma cells. R-LP encapsulating eIF3i shRNA gene (R-LP/sheIF3i) were prepared by a film dispersion method. The transfection experiment proves that R-LP could effectively transfect B16F10 cells. R-LP/sheIF3i notably restrained the migration, invasion and adhesion of melanoma cells in vitro. In a mouse model of lung metastasis, R-LP/sheIF3i administered by intravenous injection suppressed pulmonary metastasis of melanoma by dramatically downregulated eIF3i expression and subsequently inhibiting tumor neovascularization and tumor cells proliferation in vivo. Our results provide a basis for tumor cells targeting strategies to reduce the expression of eIF3i by RNAi in the treatment of tumor metastasis.

10.
ISME J ; 2019 Nov 25.
Artigo em Inglês | MEDLINE | ID: mdl-31767943

RESUMO

Symbiont-mediated nutritional mutualisms can contribute to the host fitness of insects, especially for those that feed exclusively on nutritionally unbalanced diets. Here, we elucidate the importance of B group vitamins in the association of endosymbiotic bacteria Wolbachia with two plant-sap feeding insects, the small brown planthopper, Laodelphax striatellus (Fallén), and the brown planthopper, Nilaparvata lugens (Stål). Infected planthoppers of both species laid more eggs than uninfected planthoppers, while the experimental transfer of Wolbachia into uninfected lines of one planthopper species rescued this fecundity deficit. The genomic analysis showed that Wolbachia strains from the two planthopper species encoded complete biosynthesis operons for biotin and riboflavin, while a metabolic analysis revealed that Wolbachia-infected planthoppers of both species had higher titers of biotin and riboflavin. Furthermore, experimental supplementation of food with a mixture of biotin and riboflavin recovered the fecundity deficit of Wolbachia-uninfected planthoppers. In addition, comparative genomic analysis suggested that the riboflavin synthesis genes are conserved among Wolbachia supergroups. Biotin operons are rare in Wolbachia, and those described share a recent ancestor that may have been horizontally transferred from Cardinium bacteria. Our research demonstrates a type of mutualism that involves a facultative interaction between Wolbachia and plant-sap feeding insects involving vitamin Bs.

11.
Nanoscale ; 11(42): 19903-19911, 2019 Nov 14.
Artigo em Inglês | MEDLINE | ID: mdl-31599909

RESUMO

Seeking novel superatoms with tunable electronic and magnetic properties has attracted much interest due to their potential application in cluster assembly nanomaterials. By employing density functional theory (DFT) calculations, the recently observed superatomic WC cluster was adopted as the basic unit to construct larger polymeric clusters, namely (WC)n (n = 2-7), and their structural evolution was explored to understand the growth pattern of these superatomic clusters into nanoscale materials. An unusual odd-even pattern in structural evolution was disclosed, in which the (WC)2 unit is considered as the basic building block. Moreover, W4C4 is found to possess a cubic structure, based on which the CO and PH3 ligands were attached to examine their ligation effects on W4C4. Theoretical results show that the electronic properties of W4C4 can be dramatically altered during the ligation process. Intriguingly, the continuous attachment of CO and PH3 ligands strongly increases and decreases the electron affinities (EA) and ionization potentials (IP) of the ligated W4C4 clusters, respectively, leading to the formation of superhalogen and superalkali species with high magnetic moments. The observed ligand induced strategy highlighted here could serve as an effective way to tune the electronic and magnetic properties of clusters resulting in the formation of novel superatoms. Finally, studies on the geometrical and electronic structures of the W4C4 cluster solid unveil its special 3-D cubic honeycomb geometry and metallic properties with predominant contribution from the 5d of W, which may have potential applications in electro-catalysis.

12.
Curr Top Med Chem ; 19(25): 2301-2317, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31622219

RESUMO

In recent years, the successful implementation of human genome project has made people realize that genetic, environmental and lifestyle factors should be combined together to study cancer due to the complexity and various forms of the disease. The increasing availability and growth rate of 'big data' derived from various omics, opens a new window for study and therapy of cancer. In this paper, we will introduce the application of machine learning methods in handling cancer big data including the use of artificial neural networks, support vector machines, ensemble learning and naïve Bayes classifiers.

13.
Artigo em Inglês | MEDLINE | ID: mdl-31652708

RESUMO

The effects of Cd, Cd + Fe, and Cd + Ni on the thermophilic anaerobic fermentation of corn stover and cow manure were studied in pilot experiments by investigating the biogas properties, process stability, substrate biodegradation, and microbial properties. The results showed that the addition of Fe and Ni into the Cd-containing fermentation system induced higher cumulative biogas yields and NH4+-N concentrations compared with the only Cd-added group. Ni together with Cd improved and brought forward the peak daily biogas yields, and increased the CH4 contents to 80.76%. Taking the whole fermentation process into consideration, the promoting impact of the Cd + Ni group was mainly attributed to better process stability, a higher average NH4+-N concentration, and increased utilization of acetate. Adding Fe into the Cd-containing fermentation system increased the absolute abundance of Methanobrevibacter on the 13th day, and Methanobrevibacter and Methanobacterium were found to be positively correlated with the daily biogas yield. This research was expected to provide a basis for the reuse of biological wastes contaminated by heavy metals and a reference for further studies on the influence of compound heavy metals on anaerobic fermentation.

14.
ACS Appl Mater Interfaces ; 11(45): 42358-42364, 2019 Nov 13.
Artigo em Inglês | MEDLINE | ID: mdl-31633328

RESUMO

Two-dimensional material-based ferroelectric field-effect transistors (2D-FeFETs) hold great promise in information storage and processing. However, an often-observed and hard-to-control anti-hysteresis response of 2D-FeFETs, for example, hysteretic switching of the resistance states of the devices opposite to that of the actual polarization of the ferroelectric dielectric, represents a major issue in the industrial applications of such devices. Here, we demonstrate a van der Waals buffer technique that eliminates anti-hysteresis in black phosphorus (BP) 2D-FeFETs and restores their intrinsic hysteretic behavior. Our modified BP 2D-FeFETs showed outstanding performance including high room-temperature carrier mobility, robust bistable states with fast response to a gate, a large on/off ratio at zero gate voltage, a large and considerably more stable memory window, and a long retention time. During repeated gate operation, the memory window of the buffered device is ∼7000 times more stable than the unbuffered device. Such a method could be crucial in future information technological applications that utilize the intrinsic properties of 2D-FeFETs.

15.
Am J Hum Genet ; 105(4): 803-812, 2019 Oct 03.
Artigo em Inglês | MEDLINE | ID: mdl-31564438

RESUMO

Concurrent hearing and genetic screening of newborns is expected to play important roles not only in early detection and diagnosis of congenital deafness, which triggers intervention, but also in predicting late-onset and progressive hearing loss and identifying individuals who are at risk of drug-induced HL. Concurrent hearing and genetic screening in the whole newborn population in Beijing was launched in January 2012. This study included 180,469 infants born in Beijing between April 2013 and March 2014, with last follow-up on February 24, 2018. Hearing screening was performed using transiently evoked otoacoustic emission (TEOAE) and automated auditory brainstem response (AABR). For genetic testing, dried blood spots were collected and nine variants in four genes, GJB2, SLC26A4, mtDNA 12S rRNA, and GJB3, were screened using a DNA microarray platform. Of the 180,469 infants, 1,915 (1.061%) were referred bilaterally or unilaterally for hearing screening; 8,136 (4.508%) were positive for genetic screening (heterozygote, homozygote, or compound heterozygote and mtDNA homoplasmy or heteroplasmy), among whom 7,896 (4.375%) passed hearing screening. Forty (0.022%) infants carried two variants in GJB2 or SLC26A4 (homozygote or compound heterozygote) and 10 of those infants passed newborn hearing screening. In total, 409 (0.227%) infants carried the mtDNA 12S rRNA variant (m.1555A>G or m.1494C>T), and 405 of them passed newborn hearing screening. In this cohort study, 25% of infants with pathogenic combinations of GJB2 or SLC26A4 variants and 99% of infants with an m.1555A>G or m.1494C>T variant passed routine newborn hearing screening, indicating that concurrent screening provides a more comprehensive approach for management of congenital deafness and prevention of ototoxicity.

16.
Zhongguo Zhong Yao Za Zhi ; 44(17): 3745-3748, 2019 Sep.
Artigo em Chinês | MEDLINE | ID: mdl-31602948

RESUMO

A new isobenzofuranone derivative was isolated from Chaenomeles sinensis by using various chromatographic techniques,including silica gel,Sephadex LH-20,MCI-gel resin and RP-HPLC. This compound was determined as 2,2-dimethyl-5-( 2-oxopropyl)-2 H-furo[3,4-h]chromen-7( 9 H)-one( 1) by NMR,MS,IR and UV spectra,and was also evaluated for its antibacterial activity. The results showed that it showed prominent antibacterial activity with MIC90 value of( 53. 7±4. 5) mg·L-1 for methicillin resistant Staphylococcus aureus( MRSA) strain. This value is close to that of levofloxacin [with MIC90 value( 50. 2± 4. 2) mg·L-1].


Assuntos
Antibacterianos/farmacologia , Benzofuranos/farmacologia , Staphylococcus aureus Resistente à Meticilina/efeitos dos fármacos , Rosaceae/química , Antibacterianos/isolamento & purificação , Benzofuranos/isolamento & purificação , Cromatografia Líquida de Alta Pressão , Testes de Sensibilidade Microbiana , Compostos Fitoquímicos/isolamento & purificação , Compostos Fitoquímicos/farmacologia
18.
Redox Biol ; 28: 101309, 2019 Aug 27.
Artigo em Inglês | MEDLINE | ID: mdl-31487581

RESUMO

The dysregulation of ROS production and osteoclastogenesis is involved in the progress of osteoporosis. To identify novel and effective targets to treat this disease, it is important to explore the underlying mechanisms. In our study, we firstly tested the effect of the Nrf2 activator RTA-408, a novel synthetic triterpenoid under clinical investigation for many diseases, on osteoclastogenesis. We found that it could inhibit osteoclast differentiation and bone resorption in a time- and dose-dependent manner. Further, RTA-408 enhanced the expression and activity of Nrf2 and significantly suppressed RANKL-induced reactive oxygen species (ROS) production. Nrf2 regulates the STING expression and STING induces the production of IFN-ß. Here, we found that RTA-408 could suppress STING expression, but that it does not affect Ifnb1 expression. RANKL-induced degradation of IκBα and the nuclear translocation of P65 was suppressed by RTA-408. Although this compound was not found to influence STING-IFN-ß signaling, it suppressed the RANKL-induced K63-ubiquitination of STING via inhibiting the interaction between STING and the E3 ubiquitin ligase TRAF6. Further, adenovirus-mediated STING overexpression rescued the suppressive effect of RTA-408 on NF-κB signaling and osteoclastogenesis. In vivo experiments showed that this compound could effectively attenuate ovariectomy (OVX)-induced bone loss in C57BL/6 mice by inhibiting osteoclastogenesis. Collectively, we show that RTA-408 inhibits NF-κB signaling by suppressing the recruitment of TRAF6 to STING, in addition to attenuating osteoclastogenesis and OVX-induced bone loss in vivo, suggesting that it could be a promising candidate for treating osteoporosis in the future.

19.
FASEB J ; 33(11): 12929-12940, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31490085

RESUMO

The endogenous metabolite itaconate has emerged as a regulator of macrophage function that limits inflammation. However, its effect on cell differentiation and osteoclast-related diseases is unclear. Here, for the first time, we explored the effect of itaconate and its cell-permeable itaconate derivative, 4-octyl itaconate (OI) on osteoclast differentiation in vitro and in vivo. Firstly, we demonstrated that itaconate concentration was lower in estrogen-deficient mice. OI released itaconate and induced the expression of nuclear factor-erythroid 2-related factor 2 (Nrf2) in bone marrow-derived macrophages during osteoclastogenesis. Furthermore, OI significantly suppressed the early, middle, and late stages of osteoclastogenesis induced by receptor activator of NF-κB ligand in vitro, as confirmed by tartrate-resistant acid phosphatase staining. Moreover, it significantly inhibited fibrous actin ring formation and bone resorption in vitro. Mechanistically, we observed that OI enhanced Nrf2 expression by suppressing its association with ubiquitin via inhibition of the E3 ubiquitin ligase (Hrd1). OI also inhibited LPS-induced the reactive oxygen species and inflammatory responses via Hrd1. An estrogen deficiency (via ovariectomy)-induced osteoporosis model was also established. Here, on micro-computed tomography and histologic analysis showed that OI effectively suppressed ovariectomy-induced bone loss. In summary, OI, an itaconate derivative, can inhibit osteoclastogenesis in vitro and in vivo, indicating that OI could be a potential drug to treat osteoclast-related diseases; our results also link itaconate to the development of osteoporosis.-Sun, X., Zhang, B., Pan, X., Huang, H., Xie, Z., Ma, Y., Hu, B., Wang, J., Chen, Z., Shi, P. Octyl itaconate inhibits osteoclastogenesis by suppressing Hrd1 and activating Nrf2 signaling.

20.
Cancer Res ; 79(21): 5626-5639, 2019 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-31519688

RESUMO

Neutrophil infiltration and neutrophil extracellular traps (NET) in solid cancers are associated with poorer prognosis, but the mechanisms are incompletely understood. We hypothesized that NETs enhance mitochondrial function in tumor cells, providing extra energy for accelerated growth. Metastatic colorectal cancer tissue showed increased intratumoral NETs and supranormal preoperative serum MPO-DNA, a NET marker. Higher MPO-DNA correlated with shorter survival. In mice, subcutaneous tumor implants and hepatic metastases grew slowly in PAD4-KO mice, genetically incapable of NETosis. In parallel experiments, human cancer cell lines grew slower in nu/nu mice treated with DNAse, which disassembles NETs. PAD4-KO tumors manifested decreased proliferation, increased apoptosis, and increased evidence of oxidative stress. PAD4-KO tumors had decreased mitochondrial density, mitochondrial DNA, a lesser degree of ATP production, along with significantly decreased mitochondrial biogenesis proteins PGC1α, TFAM, and NRF-1. In vitro, cancer cells treated with NETs upregulated mitochondrial biogenesis-associated genes, increased mitochondrial density, increased ATP production, enhanced the percentage of cancer cells with reduced mitochondrial membrane potential, and increased the oxygen consumption rate. Furthermore, NETs increased cancer cells' expression of fission and fusion-associated proteins, DRP-1 and MFN-2, and mitophagy-linked proteins, PINK1 and Parkin. All of which were decreased in PAD4-KO tumors. Mechanistically, neutrophil elastase released from NETs activated TLR4 on cancer cells, leading to PGC1α upregulation, increased mitochondrial biogenesis, and accelerated growth. Taken together, NETs can directly alter the metabolic programming of cancer cells to increase tumor growth. NETs represent a promising therapeutic target to halt cancer progression. SIGNIFICANCE: Neutrophils through the release of NETs facilitate the growth of stressed cancer cells by altering their bioenergetics, the inhibition of which induces cell death.

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