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Theor Appl Genet ; 129(4): 753-765, 2016 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-26849239


KEY MESSAGE: Molecular characterization information on genetic diversity, population structure and genetic relationships provided by this research will help maize breeders to better understand how to utilize the current CML collection. CIMMYT maize inbred lines (CMLs) have been widely used all over the world and have contributed greatly to both tropical and temperate maize improvement. Genetic diversity and population structure of the current CML collection and of six temperate inbred lines were assessed and relationships among all lines were determined with genotyping-by-sequencing SNPs. Results indicated that: (1) wider genetic distance and low kinship coefficients among most pairs of lines reflected the uniqueness of most lines in the current CML collection; (2) the population structure and genetic divergence between the Temperate subgroup and Tropical subgroups were clear; three major environmental adaptation groups (Lowland Tropical, Subtropical/Mid-altitude and Highland Tropical subgroups) were clearly present in the current CML collection; (3) the genetic diversity of the three Tropical subgroups was similar and greater than that of the Temperate subgroup; the average genetic distance between the Temperate and Tropical subgroups was greater than among Tropical subgroups; and (4) heterotic patterns in each environmental adaptation group estimated using GBS SNPs were only partially consistent with patterns estimated based on combining ability tests and pedigree information. Combining current heterotic information based on combining ability tests and the genetic relationships inferred from molecular marker analyses may be the best strategy to define heterotic groups for future tropical maize improvement. Information resulting from this research will help breeders to better understand how to utilize all the CMLs to select parental lines, replace testers, assign heterotic groups and create a core set of breeding germplasm.

Genótipo , Vigor Híbrido , Polimorfismo de Nucleotídeo Único , Zea mays/genética , DNA de Plantas/genética , Frequência do Gene , Endogamia , Melhoramento Vegetal , Análise de Sequência de DNA
PLoS One ; 10(7): e0132379, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26148055


Genomic selection is a promising research area due to its practical application in breeding. In this study, impact of realized genetic relationship and linkage disequilibrium (LD) on marker density and training population size required was investigated and their impact on practical application was further discussed. This study is based on experimental data of two populations derived from the same two founder lines (B73, Mo17). Two populations were genotyped with different marker sets at different density: IBM Syn4 and IBM Syn10. A high-density marker set in Syn10 was imputed into the Syn4 population with low marker density. Seven different prediction scenarios were carried out with a random regression best linear unbiased prediction (RR-BLUP) model. The result showed that the closer the real genetic relationship between training and validation population, the fewer markers were required to reach a good prediction accuracy. Taken the short-term cost for consideration, relationship information is more valuable than LD information. Meanwhile, the result indicated that accuracies based on high LD between QTL and markers were more stable over generations, thus LD information would provide more robust prediction capacity in practical applications.

Desequilíbrio de Ligação , Modelos Genéticos , Seleção Genética , Zea mays/genética
Artigo em Inglês | MEDLINE | ID: mdl-24146506


UNLABELLED: The objectives of this study were to learn about the characteristics and rules of the occurrence of adverse reactions caused by lactam antibiotics and provide a reference for clinical drug use. METHODS: A retrospective study was made to analyse the 113 case reports of adverse reactions caused by ß-lactam antibiotics collected in our hospital between 2007 and 2009. RESULTS: 113 cases of ADR involved 17 kinds of ß-lactam antibiotics, headed by ceftriaxone sodium. The most common manifestation was skin and accessory damage; nervous system and gastrointestinal system damage were also easier to find, and the administration route was mainly intravenous infusion. CONCLUSION: The clinical application of ß-lactam antibiotics should pay attention to adverse reaction monitoring and rational drug use to reduce the incidence of adverse reactions.

Antibacterianos/efeitos adversos , beta-Lactamas/efeitos adversos , Adolescente , Adulto , Antibacterianos/administração & dosagem , Ceftriaxona/efeitos adversos , Criança , Feminino , Trato Gastrointestinal/efeitos dos fármacos , Humanos , Masculino , Pessoa de Meia-Idade , Sistema Nervoso/efeitos dos fármacos , Estudos Retrospectivos , Pele/efeitos dos fármacos , Adulto Jovem , beta-Lactamas/administração & dosagem