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1.
BMC Nurs ; 20(1): 236, 2021 Nov 23.
Artigo em Inglês | MEDLINE | ID: mdl-34814906

RESUMO

BACKGROUND: Peripheral intravenous catheters (PIVCs) are the most widely used intravenous treatment tools for hospitalized patients. Compared to adult patients, PIVC fixation issues are more likely to occur in pediatric patients and can be more complex. However, research on PIVC fixation in pediatric patients is rare. This study aimed to investigate the pass rate for PIVC fixation in pediatric patients and the factors that influence pediatric nurses' knowledge, attitude, and practice (KAP) concerning PIVC fixation. METHODS: An on-site investigation using a self-designed PIVC fixation standard inspection checklist for first insertion and routine maintenance in pediatric patients and a follow-up questionnaire survey investigating pediatric nurses' KAP concerning PIVC fixation was conducted in a hospital in China between November 1 and December 31, 2019. Data were analyzed using SPSS 21.0. RESULTS: The pass rate for PIVC fixation in pediatric patients was 52.02%. The pediatric nurses' knowledge, attitude and practice scores on PIVC fixation were 7.2 ± 1.36, 28.03 ± 2.42, and 31.73 ± 2.94, respectively. The multivariate linear regression analysis results show that department (where nurses are working in) and job position are the factors that influence knowledge score (B > 0, P < 0.05); department is also a factor that influences attitude score (B > 0, P < 0.05); and department and nursing hierarchy are the factors that influence practice score (B > 0, P < 0.05). CONCLUSION: PIVC fixation in pediatric patients is affected by multiple factors. The level of pediatric nurses' KAP on PIVC fixation needs to be improved. It is suggested that guidelines for PIVC fixation in pediatric patients be formulated and that training on PIVC fixation in pediatric patients be provided for pediatric nurses in an effort to raise the pass rate in terms of PIVC fixation in pediatric patients.

2.
Org Lett ; 23(17): 6750-6755, 2021 Sep 03.
Artigo em Inglês | MEDLINE | ID: mdl-34406770

RESUMO

The catalytic diastereo- and enantioselective syntheses of C2-symmetric axially chiral 1,4-dicarbonyl derivatives with 2,3-quaternary stereocenters were achieved by utilizing an organo-/iodine binary catalytic strategy. The reactions proceeded well under mild conditions without metals or strong bases.

3.
Chem Commun (Camb) ; 57(52): 6424-6427, 2021 Jun 29.
Artigo em Inglês | MEDLINE | ID: mdl-34095920

RESUMO

A new and efficient strategy for ring-opening reactions of nitrocyclopropanes is developed for the first time for the divergent synthesis of enynes and enesters via in situ generated highly reactive electron-deficient intermediate allenes. Controllable approaches resulted in enynes and enesters with up to 89% and 90% yields, respectively. The reaction features easy operation, involves green solvents and simple inorganic bases, and is transition-metal free.

4.
Ecol Evol ; 8(10): 4967-4977, 2018 May.
Artigo em Inglês | MEDLINE | ID: mdl-29876074

RESUMO

Given the low substitution rate in plastomes, the polymorphic and codominant nature of chloroplast SSRs (cpSSRs) makes them ideal markers, complementing their nuclear counterpart. In Cupressaceae, cpSSRs are mostly paternally inherited, thus, they are useful in mating systems and pollen flow studies. Using e-PCR, 92 SSR loci were identified across six Cupressaceae plastomes, and primers were designed for 26 loci with potential interspecific transferability. The 26 developed cpSSRs were polymorphic in four genera, Platycladus, Sabina, Juniperus, and Cupressus and are suitable for Cupressaceae molecular genetic studies and utilization. We genotyped 192 Platycladus orientalis samples from a core breeding population using 10 of the developed cpSSRs and 10 nuclear SSRs, and these individuals were identified with high confidence. The developed cpSSRs can be used in (1) a marker-assisted breeding scheme, specifically when paternity identification is required, (2) population genetics investigations, and (3) biogeography of Cupressaceae and unraveling the genetic relationships between related species.

5.
Sci Rep ; 6: 34821, 2016 10 10.
Artigo em Inglês | MEDLINE | ID: mdl-27721449

RESUMO

Platycladus orientalis, a widespread conifer with long lifespan and significant adaptability. It is much used in reforestation in north China and commonly planted in central Asia. With the increasing demand for plantation forest in central to north China, breeding programs are progressively established for this species. Efficient use of breeding resources requires good understanding of the genetic value of the founder breeding materials. This study investigated the distribution of genetic variation in 192 elite trees collected for the breeding program for the central range of the species. We developed first set of 27 polymorphic EST-derived SSR loci for the species from transcriptome/genome data. After examination of amplification quality, 10 loci were used to evaluate the genetic variation in the breeding population. We found moderate genetic diversity (average He = 0.348) and low population differentiation (Fst = 0.011). Extensive admixture and no significant geographic population structure characterized this set of collections. Our analyses of the diversity and population structure are important steps toward a long-term sustainable deployment of the species and provide valuable genetic information for conservation and breeding applications.


Assuntos
Cupressaceae/genética , Variação Genética , China , Etiquetas de Sequências Expressas , Agricultura Florestal/métodos , Genética Populacional , Repetições de Microssatélites , Melhoramento Vegetal , Polimorfismo Genético
6.
Zhen Ci Yan Jiu ; 41(1): 24-30, 2016 Feb.
Artigo em Chinês | MEDLINE | ID: mdl-27141616

RESUMO

OBJECTIVE: To investigate the protection mechanism of electroacupuncture (EA) therapy against Alzheimer's disease (AD)-like neurotoxicity induced by Isoflurane. METHODS: Twenty-four APPswe/PS 1 dE9 double transgenic mice (one of the most extensively used transgenic mouse model of AD) and 24 littermate wild-type mice were randomly assigned into control (Con) group, isoflurane (Iso) group and EA group, respectively (n = 8 in each group). EA (2 Hz/100 Hz, 1 mA) was applied to "Baihui" (GV 20) and "Yongquan" (KI 1) for 15 min, once a day for 3 days. The transgenic mice were exposed to a closed box filled with 1.2% isoflurane + 30% O2 +70% N2 for 4 h. The animals' learning-memory ability was detected by Morris water maze test. The expression of cleaved Caspase-3 in the CA 1 area of hippocampus was detected by immunohistochemistry, and that of hippocampal Bcl-2 and Bax proteins detected by Western blot. RESULTS: Compared with the wilde-type mice, the average escape latency of place navigation test was significantly longer, while the percentage of target-quadrant stay time and the target- platform crossing times of spacial probe test were marked decreased in AD + lso mice (P < 0.05). After acupuncture intervention, the abovementioned changes were reversed (P < 0.05). Correspondingly, compared with the AD-Con group, the number of hippocampal activated Caspase-3-positive cells and the expression of Bax protein were significantly increased in the AD-Iso group (P < 0.05). After EA intervention, the increased Caspase-3-positive cell number and Bax protein expression were remarkably down-regulated in the AD-EA group, and the decreased ratio of Bcl-2/Bax in AD-Iso mice was obviously up-regulated in AD-EA mice (P < 0.05). No significant changes were found in the average escape latency, the percentage of target-quadrant stay time and the target-platofrm corssing times, and inthe number of hippocampal activated Caspase-3-positive cells, the expression levels of hippocampal Bcl-2 and Sax and the ratio of Bcl-2/Bax in the three groups of wilde-type mice (P > 0.05). CONCLUSION: EA intervention can improve the learning-memory ability in AD + Isoflurane mice, suggesting a reduction of AD-like neurotoxicity, which may be associated with its actions in inhibiting the overexpression of activated Caspase-3 and Bax proteins in the hippocampus.


Assuntos
Doença de Alzheimer/psicologia , Doença de Alzheimer/terapia , Caspase 3/metabolismo , Eletroacupuntura , Hipocampo/metabolismo , Isoflurano/efeitos adversos , Proteína X Associada a bcl-2/metabolismo , Doença de Alzheimer/genética , Doença de Alzheimer/metabolismo , Animais , Caspase 3/genética , Modelos Animais de Doenças , Feminino , Humanos , Aprendizagem , Memória , Camundongos , Camundongos Transgênicos , Proteína X Associada a bcl-2/genética
7.
J Tradit Chin Med ; 29(1): 19-23, 2009 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-19514183

RESUMO

OBJECTIVE: To evaluate the therapeutic effects of needle-rolling therapy for chronic insomnia. METHODS: In the present multi-central randomly controlled clinical study, 180 cases of chronic insomnia were randomly divided into the following two groups, a treatment group (90 cases) treated by the needle-rolling therapy and a control group (90 cases) treated with clonopin. The treatment course for both the two groups was 4 weeks. The therapeutic effects were evaluated based on improvement of the TCM symptoms and the Pittsburgs's sleep-quality index (PSQI). RESULTS: After treatment, there were significant differences between the two groups in the effective rate (P<0.05), and in the total score of PSQI and in the scores of the 4 sub-items, i.e. sleep-quality, sleep-efficiency, hypnotic and daytime function (P<0.05). Although there was no significant difference between the two groups in the effective rate after a 3-month follow-up period, significant differences still existed in the 3 sub-items of sleep-efficiency, hypnotic, and daytime function of the PSQI (P<0.05). CONCLUSION: As compared with hypnotics of the second generation, the needle-rolling therapy may show better therapeutic effects for chronic insomnia patients.


Assuntos
Terapia por Acupuntura/métodos , Distúrbios do Início e da Manutenção do Sono/terapia , Adolescente , Adulto , Idoso , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Adulto Jovem
8.
Zhong Yao Cai ; 32(1): 65-6, 2009 Jan.
Artigo em Chinês | MEDLINE | ID: mdl-19445124

RESUMO

OBJECTIVE: To analyze the chemical constituents of the volatile oil from the flowers of Oyster Rhoeo. METHODS: The volatile oil from the flower of Oyster Rhoeo was extracted by steam distillation and its chemical constituents were analyzed by GC/MS technique. RESULTS: All 20 compounds which relative content was greater than 0.3% were identified, accounting for 90.24% of the volatile oil. CONCLUSION: The major constituent of the volatile oil is nonaldehyde (25.72%), the other main constituents are hexadecanoid acid (22.79%), nonanoic acid (18.94%), dodecanoic acid (7.72%), isovanillin (2.84%), heptanoic acid (2.20%), octanoic acid (1.89%) and linoleic acid (1.71%), respectively.


Assuntos
Commelinaceae/química , Ácidos Graxos/análise , Flores/química , Óleos Voláteis/química , Plantas Medicinais/química , Cromatografia Gasosa-Espectrometria de Massas , Ácidos Láuricos/análise , Óleos Voláteis/isolamento & purificação , Ácido Palmítico/análise
9.
Huan Jing Ke Xue ; 27(6): 1123-6, 2006 Jun.
Artigo em Chinês | MEDLINE | ID: mdl-16921947

RESUMO

The synergistic effects of ultra sound and zero-valent iron were studied by measuring the degradation of X-3B in zero-valent reduction, ultra sound degradation and synergistic systems. The effects of pH, ultra sound power and irradiation time on the synergistic system were explored. The results show that the X-3B is degraded difficultly by ultra sound and the total removal rate is less than 7.75% after 25min ultrasonic irradiation. When pH is 5.0, 7.0 and 9.0, the degradation rate of X-3B in synergistic system is about 1.68, 1.76 and 1.67 times, respectively, than the total removal rate of zero-valent iron reduction plus ultrasound degradation. After 25min ultrasonic irradiation in synergistic system, 99.42% of X-3B is removed at pH7.0. However, the degradation rate of X-3B in zero-valent iron reduction system is much higher than that of synergistic system at pH3.0. The degradation mechanism of X-3B in zero-valent iron reduction system is different from that of synergistic system. The X-3B is degraded into intermediate pollutants in the former, but is degraded completely in the latter. Accordingly, the X-3B can be degraded effectively in the synergistic system of zero-valent iron and ultra sound, when pH is 5.0 approximately 7.0 and the power of ultra sound is 400 approximately 600W.


Assuntos
Ciclobutanos/química , Indóis/química , Ferro/química , Ultrassom , Eliminação de Resíduos Líquidos/métodos , Compostos Azo/química , Indústria Têxtil , Purificação da Água/métodos
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