Your browser doesn't support javascript.
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 35
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Molecules ; 24(19)2019 Oct 08.
Artigo em Inglês | MEDLINE | ID: mdl-31597363

RESUMO

Two new triterpenoids, named kadsuricoccins A and B, together with three known ones, were isolated from the Li folk herb Heilaohu, the stems of Kadsura coccinea (Lem.) A. C. Smith, which was used for food and as a healthy supplement. Their structures were elucidated by comprehensive analyses of mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopic data. To search healthy components, an acetylcholinesterase (AChE) inhibitory activity test by Ellman's Method was conducted, kadsuricoccins A and B showed activity with the AChE inhibit index (AII) up to 68.96% ± 0.19% and 57.8% ± 0.11% at 94 nM (compared with positive control tacrine AII 79.80% ± 0.20%, 9.4 nM), respectively.


Assuntos
Inibidores da Colinesterase/isolamento & purificação , Inibidores da Colinesterase/farmacologia , Medicamentos de Ervas Chinesas/isolamento & purificação , Medicamentos de Ervas Chinesas/farmacologia , Kadsura/química , Caules de Planta/química , Inibidores da Colinesterase/química , Relação Dose-Resposta a Droga , Medicamentos de Ervas Chinesas/química , Ativação Enzimática/efeitos dos fármacos , Espectroscopia de Ressonância Magnética , Estrutura Molecular
2.
Phytochemistry ; 159: 208-215, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30634083

RESUMO

Twelve undescribed compounds including six phenanthrene derivatives (parviphenanthrines A-F), two stilbene derivatives (parvistilbines A-B), three esters (parviesters A-C), and one sesquiterpenoid (parvidiol A) were isolated from the roots of Stemona parviflora, together with twenty-two known ones. The structures of the undescribed compounds were elucidated based on the analyses of their spectroscopic data. The absolute configuration of parviphenanthrine A was determined by the quantum ECD calculations. Parviphenanthrines A and E, stemanthrene A, stilbostenin E, 4-hydroxy-benzenepropanol-α-benzoate, and (E)-4-hydroxycinnamic acid methyl ester showed nematocidal activity against Meloidogyne incognita with IC50 values of 14.02 ±â€¯0.32, 2.51 ±â€¯0.13, 17.10 ±â€¯0.65, 2.05 ±â€¯0.07, 4.22 ±â€¯0.31, and 1.07 ±â€¯0.05 µM, respectively.


Assuntos
Antinematódeos/farmacologia , Compostos Fitoquímicos/química , Extratos Vegetais/farmacologia , Raízes de Plantas/química , Stemonaceae/química , Concentração Inibidora 50 , Estrutura Molecular
3.
Molecules ; 23(10)2018 Sep 21.
Artigo em Inglês | MEDLINE | ID: mdl-30248957

RESUMO

Daphnauranins C⁻E (compounds 1⁻3), two sesquiterpenoids and one monoterpenoid were isolated from the roots of Daphne aurantiaca Diels. Daphnauranin C is a 9-O-13 etherified and hydroperoxy-substituted guaiane sesquiterpenoid, daphnauranin D is a guaiane sesquiterpenoid ketal, and daphnauranin E is a monoterpenoid lactone. Their structures were elucidated by comprehensive analyses of MS, 1D NMR, and 2D NMR spectroscopic data. In an anti-feeding activities test, daphnauranins C⁻E showed activity against male fruit fly with anti-feeding indexes (AI) up to 39.1, 39.2, and 27.8% respectively, at 1 mM.


Assuntos
Daphne/química , Drosophila melanogaster/efeitos dos fármacos , Repelentes de Insetos/química , Sesquiterpenos/química , Animais , Drosophila melanogaster/fisiologia , Repelentes de Insetos/farmacologia , Espectroscopia de Ressonância Magnética , Masculino , Estrutura Molecular , Raízes de Plantas/química , Sesquiterpenos/farmacologia
4.
Fitoterapia ; 125: 217-220, 2018 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-29197542

RESUMO

An unusual adenine-substituted germacrane sesquiterpene lactone, tomenphantadenine (1), has been isolated from the whole plant of Elephantopus tomentosus L. The structure of this compound was established by comprehensive spectroscopic analysis including high resolution (HR) ESI-MS, 1D and 2D nuclear magnetic resonance (NMR) spectroscopic data. This compound features novel hybrid pattern of germacrane sesquiterpene with adenine through C-N linkage, and a possible biosynthetic pathway for it was proposed. Compound 1 showed potent antibacterial activity against the gram-positive Staphylococcus aureus and weak acetylcholinesterase (AChE) inhibitory activity.


Assuntos
Adenina/química , Asteraceae/química , Sesquiterpenos de Germacrano/química , Adenina/isolamento & purificação , Antibacterianos/isolamento & purificação , China , Inibidores da Colinesterase/química , Inibidores da Colinesterase/isolamento & purificação , Estrutura Molecular , Plantas Medicinais/química , Sesquiterpenos de Germacrano/isolamento & purificação , Staphylococcus aureus/efeitos dos fármacos
5.
J Asian Nat Prod Res ; 20(3): 249-254, 2018 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-28508676

RESUMO

Two new compounds, philippin (1) and 3ß,9α,14α-trihydroxy-(22E,24R)-ergost-22-en-7-one (2), were isolated from the fruiting bodies of Ganoderma philippii. Their structures were elucidated on the basis of the spectroscopic technologies, including 1D and 2D NMR as well as MS. The bioassay of inhibitory activity against acetylcholinesterase (AChE) showed compound 1 exhibited weak inhibitory activity against AChE.


Assuntos
Inibidores da Colinesterase/isolamento & purificação , Ergosterol/análogos & derivados , Ganoderma/química , Hidroquinonas/isolamento & purificação , Acetilcolinesterase/efeitos dos fármacos , Inibidores da Colinesterase/química , Inibidores da Colinesterase/farmacologia , Ergosterol/química , Ergosterol/isolamento & purificação , Carpóforos/química , Hidroquinonas/química , Estrutura Molecular , Ressonância Magnética Nuclear Biomolecular
6.
Fitoterapia ; 122: 11-15, 2017 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-28821449

RESUMO

Daphnauranins A (1) and B (2), two sesquiterpenoids were isolated from the roots of Daphne aurantiaca Diels. One is an unprecedented 5/7 oxacycloheptane ring system, the other is a sesquiterpene-lignan complex. Their structures were elucidated by comprehensive spectroscopic methods including MS and NMR. Their absolute configurations were further confirmed by the quantum ECD calculations. Daphnauranins A and B showed anti-insect activities against male fruit fly with anti-feeding rate up to 46.2±7.1 and 44.7±5.4% at 1mM, respectively.


Assuntos
Daphne/química , Inseticidas/química , Lignanas/química , Raízes de Plantas/química , Sesquiterpenos/química , Animais , Drosophila melanogaster , Inseticidas/isolamento & purificação , Lignanas/isolamento & purificação , Masculino , Estrutura Molecular , Sesquiterpenos/isolamento & purificação
7.
Phytochemistry ; 143: 104-110, 2017 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-28800421

RESUMO

To search for active anti-cancer constituents in the fruiting body of Ganoderma calidophilum, we have successfully isolated four previously undescribed spiro-lactone lanostane triterpenoids (spiroganocalitones A-D), two previously undescribed lanostanoids (ganodecalones A and B) together with twenty-three known ones. The structures of the six previously undescribed compounds were elucidated based on 1D, 2D-NMR, and HRMS analyses. Ganoderone A showed moderate cytotoxic activity against K562, BEL7402, and SGC790 cell lines with IC50 values of 7.62, 6.28, and 3.55 µM, respectively.


Assuntos
Carpóforos/química , Ganoderma/química , Lanosterol/análogos & derivados , Triterpenos/isolamento & purificação , Humanos , Concentração Inibidora 50 , Lanosterol/química , Lanosterol/isolamento & purificação , Lanosterol/farmacologia , Estrutura Molecular , Ressonância Magnética Nuclear Biomolecular , Triterpenos/química , Triterpenos/farmacologia
8.
J Nat Prod ; 80(4): 1039-1047, 2017 04 28.
Artigo em Inglês | MEDLINE | ID: mdl-28212032

RESUMO

Six new meroterpenoids, chrodrimanins K-N (1-4), including two uncommon chlorinated ones (1 and 2), and verruculides B2 (5) and B3 (6), as well as seven known ones (7-13), were isolated from the fermentation broth of Penicillium sp. SCS-KFD09 isolated from a marine worm, Sipunculus nudus, from Haikou Bay, China. The structures including the absolute configurations of the new compounds were unambiguously elucidated by spectroscopic data, X-ray diffraction analysis, and ECD spectra analysis along with quantum ECD calculations. In addition, the X-ray crystal structures and absolute configurations of two previously reported meroterpenoids, chrodrimanins F (9) and A (11), are described for the first time. Compounds 1, 4, and 7 displayed anti-H1N1 activity with IC50 values of 74, 58, and 34 µM, respectively, while compound 5 showed weak inhibitory activity against Staphylococcus aureus with an MIC of 32 µg/mL.


Assuntos
Nematoides/microbiologia , Penicillium/química , Policetídeos/isolamento & purificação , Sesquiterpenos/isolamento & purificação , Terpenos/isolamento & purificação , Animais , China , Cristalografia por Raios X , Vírus da Influenza A Subtipo H1N1/efeitos dos fármacos , Biologia Marinha , Estrutura Molecular , Ressonância Magnética Nuclear Biomolecular , Policetídeos/química , Policetídeos/farmacologia , Sesquiterpenos/química , Sesquiterpenos/farmacologia , Staphylococcus aureus/efeitos dos fármacos , Terpenos/química
9.
J Asian Nat Prod Res ; 19(4): 333-338, 2017 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-27400271

RESUMO

Chemical investigation on the cultures of the fungus Psilocybe merdaria resulted in the first isolation of 10 compounds including two new ones 11,14-dihydroxylneoechinulin E (1) and (S)-4-(4-methylpent-3-en-1-yl)-butyrolactone (2). Their structures were elucidated from the analysis of 1D and 2D NMR and MS data. Among them, compound 7 showed inhibitory activity against AChE with 20% percentage at a concentration of 50 µg/ml.


Assuntos
4-Butirolactona/análogos & derivados , Inibidores da Colinesterase/isolamento & purificação , Alcaloides Indólicos/química , Psilocybe/química , 4-Butirolactona/química , 4-Butirolactona/isolamento & purificação , 4-Butirolactona/farmacologia , Acetilcolinesterase/efeitos dos fármacos , China , Inibidores da Colinesterase/química , Inibidores da Colinesterase/farmacologia , Fungos/metabolismo , Alcaloides Indólicos/isolamento & purificação , Alcaloides Indólicos/farmacologia , Concentração Inibidora 50 , Estrutura Molecular
10.
Arch Pharm Res ; 40(1): 25-31, 2017 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-27709333

RESUMO

Three new compounds named penicitor A, aculene E and penicitor B, as well as four known compounds, were isolated from the fermentation broth of Penicillium sp. SCS-KFD08 associated with a marine animal Sipunculus nudus from the Haikou bay of China. Their planar structures and absolute configurations were unambiguously elucidated by spectroscopic data, Mosher's method, CD spectrum analysis along with quantum ECD calculation. Among them, compounds 2-7 showed quorum sensing inhibitory activity against Chromobacterium violaceum CV026, and could significantly reduce violacein production in N-hexanoyl-l-homoserine lactone (C6-HSL) induced C. violaceum CV026 cultures at sub-inhibitory concentrations.


Assuntos
Organismos Aquáticos/metabolismo , Organismos Aquáticos/microbiologia , Bactérias Gram-Negativas/metabolismo , Penicillium/metabolismo , Percepção de Quorum/fisiologia , Animais , Bactérias Gram-Negativas/isolamento & purificação , Penicillium/isolamento & purificação
11.
J Nat Prod ; 79(10): 2599-2605, 2016 10 28.
Artigo em Inglês | MEDLINE | ID: mdl-27684288

RESUMO

Eight new alkaloids, 3ß-n-butylstemonamine (1), 8-oxo-3ß-n-butylstemonamine (2), 3-n-butylneostemonine (3), 10-epi-3-n-butylneostemonine (4), 8-oxo-oxymaistemonine (5) protostemonine N4-oxide (6), (19S)-hydroxy-21-methoxystemofoline (7), and parvistemonine A (8), were isolated from the roots of Stemona parviflora, together with 17 known alkaloids. The structures of the new alkaloids were elucidated based on a comprehensive spectroscopic data analysis. The absolute configurations of 1-4 were determined by the ECD exciton chirality method and quantum ECD calculations. Protostemonine (10) and stemofoline (12) showed strong nematicidal activity against Panagrellus redivevus, with IC50 values of 0.10 and 0.46 µM, respectively.


Assuntos
Alcaloides/isolamento & purificação , Alcaloides/farmacologia , Antinematódeos/isolamento & purificação , Antinematódeos/farmacologia , Medicamentos de Ervas Chinesas/isolamento & purificação , Medicamentos de Ervas Chinesas/farmacologia , Stemonaceae/química , Alcaloides/química , Antinematódeos/química , Medicamentos de Ervas Chinesas/química , Compostos Heterocíclicos de 4 ou mais Anéis , Concentração Inibidora 50 , Estrutura Molecular , Ressonância Magnética Nuclear Biomolecular , Raízes de Plantas/química
12.
Fitoterapia ; 114: 7-11, 2016 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-27502285

RESUMO

Three new sesquiterpenoids (1-3), together with two known ones were isolated from the EtOAc extract of agarwood originating from Aquilaria crassna. The new compounds were elucidated on the basis of spectroscopic techniques (UV, IR, MS, 1D and 2D NMR). Compounds 1-5 were isolated from agarwood of A. crassna for the first time. In the acetylcholinesterase inhibition experiment of 2-5, compound 3 showed acetylcholinesterase inhibition activity (IR 42.9±0.6%). Compound 5 expressed antibacterial activities against Staphylococcus aureus and Ralstonia solanacearum with diameter of the inhibition zones of 12.35±0.11mm and 16.90±0.09mm, respectively.


Assuntos
Antibacterianos/química , Inibidores da Colinesterase/química , Sesquiterpenos/química , Thymelaeaceae/química , Antibacterianos/isolamento & purificação , Inibidores da Colinesterase/isolamento & purificação , Estrutura Molecular , Ralstonia solanacearum/efeitos dos fármacos , Sesquiterpenos/isolamento & purificação , Staphylococcus aureus/efeitos dos fármacos , Madeira/química
13.
Chem Biodivers ; 13(11): 1469-1474, 2016 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-27449268

RESUMO

Two new compounds, one flavanol dimer dapholosericol A (1) and one tigliane diterpene dapholosericin A (2), together with ten known ones, were isolated from the AcOEt extract of Daphne holosericea (Diels) Hamaya. Their structures were elucidated by their spectroscopic data analysis. Compounds 1 and 2 showed moderate activities against acetylcholinesterase with inhibition ratio of 36% and 29% at a concentration of 100 µmol/l, respectively.


Assuntos
Acetilcolinesterase/metabolismo , Inibidores da Colinesterase/farmacologia , Daphne/química , Diterpenos/farmacologia , Flavonoides/farmacologia , Caules de Planta/química , Inibidores da Colinesterase/química , Inibidores da Colinesterase/isolamento & purificação , Diterpenos/química , Diterpenos/isolamento & purificação , Relação Dose-Resposta a Droga , Flavonoides/química , Flavonoides/isolamento & purificação , Estrutura Molecular , Relação Estrutura-Atividade
14.
J Asian Nat Prod Res ; 18(11): 1030-5, 2016 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-27309390

RESUMO

The chemical investigation on the fruiting bodies of Amauroderma subresinosum led to the isolation of 10 compounds including 2 new ones named amaurosubresin (1) and erythro(23,24)-5α,6α-epoxyergosta-8-ene-7-one-3ß,23-diol (2). Their structures were elucidated on the basis of 1D and 2D NMR spectroscopy as well as MS. The bioassay of inhibitory activity against acetylcholinesterase (AChE) of two new isolates exhibited definite inhibitory activity.


Assuntos
Acetilcolinesterase/efeitos dos fármacos , Inibidores da Colinesterase/isolamento & purificação , Ergosterol/análogos & derivados , Hidroquinonas/isolamento & purificação , Polyporales/química , Inibidores da Colinesterase/química , Inibidores da Colinesterase/farmacologia , Ergosterol/química , Ergosterol/isolamento & purificação , Ergosterol/farmacologia , Carpóforos/química , Hidroquinonas/química , Hidroquinonas/farmacologia , Estrutura Molecular , Ressonância Magnética Nuclear Biomolecular
15.
Molecules ; 20(2): 3281-9, 2015 Feb 16.
Artigo em Inglês | MEDLINE | ID: mdl-25690289

RESUMO

Three new lanostanoid triterpenes--ganotropic acid (1), 3ß,7ß,15α,24-tetra- hydroxy-11,23-dioxo-lanost-8-en-26-oic acid (2) and 3ß,7ß,15α,28-tetrahydroxy-11,23- dioxo-lanost-8,16-dien-26-oic acid (3)--were isolated from the n-BuOH extract of the fruiting bodies of the mushroom Ganoderma tropicum. Their structures were elucidated by 1D and 2D NMR spectroscopy, as well as HR-EI-MS data.


Assuntos
Ganoderma/química , Lanosterol/análogos & derivados , Lanosterol/química , Lanosterol/isolamento & purificação , Estrutura Molecular
16.
Phytochemistry ; 110: 133-9, 2015 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-25577284

RESUMO

Nine lanostanoids, together with nine known ones, were isolated from the ethyl acetate extract of the fruiting bodies of the mushroom Haddowia longipes. Their structures were elucidated as 11-oxo-ganoderiol D, lanosta-8-en-7,11-dioxo-3ß-acetyloxy-24,25,26-trihydroxy, lanosta-8-en-7-oxo-3ß-acetyloxy-11ß,24,25,26-tetrahydroxy, lanosta-7,9(11)-dien-3ß-acetyloxy-24,25,26-trihydroxy, lanosta-7,9(11)-dien-3ß-acetyloxy-24,26-dihydroxy-25-methoxy, 11-oxo-lucidadiol, 11ß-hydroxy-lucidadiol, lucidone H and lanosta-7,9(11),24E-trien-3ß-acetyloxy-26,27-dihydroxy by analysing their 1D/2D NMR and MS spectra. In addition, bioassays of inhibitory activity against acetylcholinesterase (AChE) of all compounds showed that thirteen compounds possessed inhibitory activity against AChE with the percentage inhibition ranging from 10.3% to 42.1% when tested at 100 µM.


Assuntos
Acetilcolinesterase/efeitos dos fármacos , Agaricales/química , Inibidores da Colinesterase/isolamento & purificação , Inibidores da Colinesterase/farmacologia , Lanosterol/análogos & derivados , Inibidores da Colinesterase/química , Lanosterol/química , Lanosterol/isolamento & purificação , Lanosterol/farmacologia , Estrutura Molecular , Ressonância Magnética Nuclear Biomolecular
17.
Molecules ; 19(9): 14266-72, 2014 Sep 11.
Artigo em Inglês | MEDLINE | ID: mdl-25215585

RESUMO

Two new sesquiterpenoids with guaiane skeletons-holosericin A (1) and holosericin B (2)-were isolated from the medicinal plant Daphne holosericea (Diels) Hamawa (Thymelaeceae). Their structures were elucidated by 1D and 2D-NMR spectroscopy, as well as HR-ESI-MS data. Compounds 1 and 2 were evaluated for inhibitory activities against acetylcholinesterase and compound 2 showed a moderate activity with 31% inhibition.


Assuntos
Inibidores da Colinesterase/química , Extratos Vegetais/química , Sesquiterpenos de Guaiano/química , Acetilcolinesterase/efeitos dos fármacos , Inibidores da Colinesterase/farmacologia , Daphne/química , Espectroscopia de Ressonância Magnética , Sesquiterpenos de Guaiano/isolamento & purificação , Sesquiterpenos de Guaiano/farmacologia
18.
Chem Biodivers ; 11(9): 1406-16, 2014 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-25238081

RESUMO

Six new compounds, including two diterpenoids excocarinols F and G (1 and 2, resp.), two carotane (daucane) sesquiterpenoids excoecafolinols A and B (3 and 4, resp.), one lignanoid compound, excoecanol A (5), and one simple phenol, excoecanol B (6), together with 17 known compounds, were isolated from the BuOH extract of Excoecaria acerifolia Didr. stems. Their structures were elucidated through the analysis of the spectroscopic data. The AChE-inhibitory activities of 17 compounds were evaluated and revealed that four of them possessed moderate inhibitory activities against AChE.


Assuntos
Inibidores da Colinesterase/isolamento & purificação , Euphorbiaceae/química , Extratos Vegetais/isolamento & purificação , Caules de Planta/química , Inibidores da Colinesterase/química , Inibidores da Colinesterase/farmacologia , Espectroscopia de Ressonância Magnética , Estrutura Molecular , Extratos Vegetais/química , Extratos Vegetais/farmacologia , Espectrometria de Massas por Ionização por Electrospray , Espectrofotometria Ultravioleta
19.
J Asian Nat Prod Res ; 16(11): 1054-9, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-25080860

RESUMO

Eight tetranortriterpenoids (1-8) and two sesquiterpenoids (9 and 10) including two new compounds, cineracipadesin G (1) and 1ß-hydroperoxy-6α-hydroxy-eudesm-4(15)-ene (9), were isolated from the EtOAc extract of branches of Cipadessa cinerascens. The structures of two new compounds were elucidated by 1D and 2D NMR and MS spectroscopic analyses. The anti-feedant activity of two tetranortriterpenoids (1 and 7) was tested and obvious anti-feedant effects were detected.


Assuntos
Drosophila melanogaster/efeitos dos fármacos , Medicamentos de Ervas Chinesas/isolamento & purificação , Medicamentos de Ervas Chinesas/farmacologia , Limoninas/isolamento & purificação , Limoninas/farmacologia , Animais , Medicamentos de Ervas Chinesas/química , Comportamento Alimentar/efeitos dos fármacos , Limoninas/química , Meliaceae/química , Estrutura Molecular , Ressonância Magnética Nuclear Biomolecular
20.
Zhongguo Zhong Yao Za Zhi ; 39(6): 1034-9, 2014 Mar.
Artigo em Chinês | MEDLINE | ID: mdl-24956846

RESUMO

The chemical investigation on Ganoderma philippii led to the isolation of sixteen compounds by silica gel and Sephadex LH-20 column chromatography. On the basis of spectroscopic data analyses, their structures were elucidated as 2, 5-dihydroxyacetophenone (1), methyl gentisate (2), (S) -dimethyl malate (3), muurola-4, 10 (14) -dien-11beta-ol (4), dihydroepicubenol (5), 5-hydroxymethylfuran carboxaldehyde (6), ergosta-7, 22E-dien-3beta-ol (7), ergosta-7, 22E-dien-3-one (8), ergosta-7, 22E-diene-2beta, 3alpha, 9alpha-triol (9), 6/beta-methoxyergo-sta-7, 22E-dien-3beta, 5alpha-diol (10), ergosta-4, 6, 8(14), 22E-tetraen-3-one (11), ergosta4, 6, 8-(14), 22E-etetraen-3beta-ol (12), 5alpha, 8alpha-epidioxy-ergosta-6, 22E-dien-3beta-ol (13), 7alpha-methoxy-5alpha, 6alpha-epoxyergosta-8-(14), 22E-dien-3beta-ol (14), ergosta-8, 22E-diene-3beta, 5alpha, 6beta, 7alpha-tetraol (15), and ergosta-5, 23-dien-3beta-ol, acetate (16). All the compounds were obtained from this fungus for the first time, and compounds 4 and 5 were isolated from the Ganoderma genus for the first time.


Assuntos
Ganoderma/química , Compostos Orgânicos/análise , Medicina Tradicional Chinesa , Compostos Orgânicos/isolamento & purificação
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA