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1.
Front Nutr ; 9: 850417, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35571888

RESUMO

Background: Dietary supplements (DSs) may be useful for managing shift work disorder. But the efficiency of outcomes in clinical trials using simulated shift work populations as subjects is controversial. This review explores the potential role of DSs for improving sleep quality, daily functioning, and mood among shift workers in the real world. Methods: A related literature search was conducted in PubMed, Web of Science, Embase, and Cochrane Library databases from their inception to July 2021. Information was collected on "shift work," "irregular working hours," "night shift," "dietary supplements," and "nutraceutical research data." Sleep quality-related scales were the primary outcome measures. The meta-analysis was conducted using RevMan 5.4 (Cochrane Collaboration, London, England) and Stata 15.0 (StataCorp, LLC, College Station, TX, USA). Heterogeneity was examined by using I 2 statistics, and publication bias was assessed via Egger's regression test. Results: Twelve studies, which involved 917 participants, met the inclusion criteria. The DS groups had significant improvement in sleep quality scores (8 randomized controlled trials [RCTs]: p = 0.04; standard mean difference (SMD), -0.45 [-0.88 to -0.03]) and daytime function (7 RCTs: p = 0.02; SMD, -0.50 [-0.92 to -0.08]). The DS groups did not have a significant improvement in psychomotor vigilance (4 RCTs: p = 0.25; SMD, 0.52 [-0.36 to 1.41]), depression (5 RCTs: p = 0.14; SMD, -0.19 [-0.45 to 0.06]), or anxiety (4 RCTs: p = 0.27; SMD, -0.23 [-0.65 to 0.18]). All RCTs suggested a positive safety profile for DSs. Conclusions: The findings of this meta-analysis indicated DSs may be beneficial for improving sleep quality and daytime function in shift workers. Although there is a wide range of DSs, the small amount of literature included for each type does not allow for subgroup analysis to be used to eliminate high heterogeneity. We have not yet included literatures on other languages either. Given these limitations of the study, there is still a need for more well-designed randomized controlled trials so that our review can be updated in the future to make the results more conclusive. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=273558, PROSPERO: CRD42021273558.

2.
Talanta ; 247: 123561, 2022 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-35609485

RESUMO

Ovarian cancer, a highly metastatic disease characterized by widespread peritoneal and ascites dissemination, is the leading cause of death from gynecological malignancies and poses a serious threat to women's lives. Biomarkers detection for the early diagnosis is crucial to ameliorate the dismal survival rate. Currently, there is much interest in lysophosphatidic acid (LPA), with evidences shown that the elevated LPA level in plasma could serve as an effective biomarker for ovarian cancer. Thus the mastery of LPA measurement techniques is conducive to providing a new diagnostic or prognostic platform for ovarian cancer. In this tutorial review, with a brief discussion on the sample pre-treatment protocols, we summarize various methods for LPA detection with emphasis on the advances in universal mass spectrometry-based technologies and emerging optical sensor strategies. Meanwhile, other methods such as enzymatic method, capillary electrophoresis, dot immunogold filtration assay and bioassay are also included. Eventually, we outlook the potential clinical value of LPA detection, and anticipate the future improvements of these methodologies to make them truly useful for ovarian cancer diagnosis.


Assuntos
Biomarcadores Tumorais , Neoplasias Ovarianas , Carcinoma Epitelial do Ovário , Feminino , Humanos , Lisofosfolipídeos
3.
Front Chem ; 10: 859948, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35402374

RESUMO

Near-infrared (NIR, 650-1700 nm) bioimaging has emerged as a powerful strategy in tumor diagnosis. In particular, NIR-I fluorescence imaging (650-950 nm) has drawn more attention, benefiting from the high quantum yield and good biocompatibility. Since their biomedical applications are slightly limited by their relatively low penetration depth, NIR-I fluorescence imaging probes have been under extensive development in recent years. This review summarizes the particular application of the NIR-I fluorescent dye-contained bimodal probes, with emphasis on related nanoprobes. These probes have enabled us to overcome the drawbacks of individual imaging modalities as well as achieve synergistic imaging. Meanwhile, the application of these NIR-I fluorescence-based bimodal probes for cancer theranostics is highlighted.

4.
Talanta ; 240: 123198, 2022 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-34998139

RESUMO

Caspase-3 plays irreplaceable roles in apoptosis and related diseases. An imbalance in the measured levels of Caspase-3 is implicated in irreversible apoptosis. Therefore, the detection of Caspase-3 is of great significance for apoptosis imaging and the evaluation effect of early tumor treatment and other diseases. Herein, advances in the recent innovations of Caspase-3 response fluorescence biosensors, including molecular probes and nanoprobes, are systematically summarized in sections corresponding. The performances of various luminescence probes in Caspase-3 detection are discussed intensively in the design strategy of chemical structure, response mechanism and biological application. Finally, the current challenges and prospects of the design of new Caspase-3 responsive fluorescence probes for apoptosis imaging, or similar molecular event are proposed.


Assuntos
Técnicas Biossensoriais , Apoptose , Caspase 3 , Luminescência , Sondas Moleculares
5.
J Nurs Manag ; 2021 Nov 07.
Artigo em Inglês | MEDLINE | ID: mdl-34747090

RESUMO

AIM: This study aims to design a 100-h training programme for nursing innovation teams and to evaluate the effect of this training programme using Kirkpatrick's model. BACKGROUND: The innovative capability of nurses is a powerful driver for the development of the nursing discipline, and it is currently at a low to medium level in China. Innovation competency development has become a research trend in nurses' in-service education, but only changes in nursing innovation behaviours before and after training have been evaluated. The cascading, continuous assessment tools are rarely used. METHODS: This is a quasi-experimental research design: pretest and posttest design. Totally, 61 clinical nurses from Hangzhou Hospital of Traditional Chinese Medicine were enrolled for innovation training. This innovation team training programme consisted of a 36-h theoretical training phase and a 64-h collaborative training phase. The four levels of Kirkpatrick's model, that is, reaction, learning, behaviour, and result, were applied for the evaluation together with questionnaires. RESULTS: At reaction level, the nurses' attendance was over 85% in two phases. The differences between nurse organizational innovation climate scores of tested nurses before and after training were statistically significant (t = -22.559, P < .001). At learning level, there were statistically significant differences between nurses' innovation self-efficacy scale scores of tested nurses before and after training (t = -16.832, P < .001). At behaviour level, the nursing innovation behaviour scale scores of tested nurses were significantly higher after training (t = -18.950, P < .001) than before the training. At result level, the clinical nurse innovation ability of tested nurses after the training were higher than before the training (t = -26.275, P < .001). The numbers of patent applications, granted patents, application for scientific research projects, sponsored scientific research projects, and papers published by team members after the training were larger than those before training (Z = -2.032, P = .042). CONCLUSION: Kirkpatrick's model can evaluate the effectiveness of nursing innovation training for clinical nurses. The nursing innovation training is beneficial to improve nurses' innovation capacity, organizational innovation climate and innovation self-efficacy, and nursing innovation behaviour and promote the output of research and innovation projects. IMPLICATIONS FOR NURSING MANAGEMENT: Managers can flexibly develop training modules with regional characteristics based on this programme to effectively improve the innovation ability of clinical nurses, thus meeting the urgent demand for innovative nursing talents and the rapid development of nursing disciplines.

6.
Opt Express ; 29(22): 35864-35876, 2021 Oct 25.
Artigo em Inglês | MEDLINE | ID: mdl-34809011

RESUMO

For a structured light system, scan speed and reconstruction accuracy are usually compromised for limited sensor bandwidth. The bio-inspired camera, also known as the event camera, has high temporal resolution and redundancy-suppressing properties, showing potential to be utilized in a high-speed structured light system. In this paper, we present an event-based structured light system for high-speed 3D scanning, which is composed of an event camera (CeleX-V) and a high-speed digital light projector (TI-DLP6500). The events are triggered by blinking a single pseudo-random pattern by controlling the projector. A simple yet effective algorithm is proposed to generate the event frames from the event stream, and a digital image correlation method is then performed to calculate the displacements, deriving the 3D surfaces of the target objects. A prototype of our proposed system is built with off-the-shelf devices and tested in both static and dynamic scenes. Experiments verify that the proposed system successfully achieves up to a 1000 fps scan rate with an accuracy of 0.27 mm at a distance of 90 cm.

7.
Ecotoxicol Environ Saf ; 228: 112980, 2021 Nov 15.
Artigo em Inglês | MEDLINE | ID: mdl-34794024

RESUMO

BACKGROUND: Electromagnetic pollution cannot be ignored. Long-term low-dose electromagnetic field (EMF) exposure can cause central nervous system dysfunction without effective prevention. MATERIALS/METHODS: Male C57BL/6J mice (6-8 weeks, 17-20 g) were used in this study. Depression-like and anxiety-like behaviors detected by behavioral experiments were compared among different treatments. 16S rRNA gene sequencing and non-targeted liquid chromatography-mass spectrometry (LC-MS) metabolomics were used to explore the relationship between EMF exposure and heat acclimation (HA) effects on gut microbes and serum metabolites. RESULTS: Both EMF and HA regulated the proportions of p_Firmicutes and p_Bacteroidota. EMF exposure caused the proportions of 6 kinds of bacteria, such as g_Butyricicoccus and g_Anaerotruncus, to change significantly (p < 0.05). HA restored the balance of gut microbes that was affected by EMF exposure and the proportion of probiotics (g_Lactobacillus) increased significantly (p < 0.01). Serum metabolite analysis suggested that HA alleviated the disturbance of serum metabolites (such as cholesterol and D-mannose) induced by EMF exposure. Both the metabolic KEGG pathways and PICRUSt functional analysis demonstrated that tryptophan metabolism, pyrimidine metabolism and amino acid biosynthesis were involved. CONCLUSIONS: EMF exposure not only led to depression-like neurobehavioral disorders, but also to gut microbiota imbalance. HA alleviated the depression features caused by EMF exposure. Based on the analysis of gut microbiota associated with serum metabolites, we speculated that gut microbiota might play a vital role in the cross-tolerance provided by HA.

8.
Anal Methods ; 13(42): 5011-5016, 2021 11 04.
Artigo em Inglês | MEDLINE | ID: mdl-34635885

RESUMO

More than 200 million people in the world are exposed to areas where the arsenic concentration exceeds the limit allowed for living species, which urges researchers to develop low-cost methods for the selective and fast detection of arsenic ions in environmental samples. Herein, we report a novel tetraphenylimidazole-based probe (TBAB) functionalized with a Schiff base for sensing and detecting arsenic ions in aqueous media. Upon the addition of arsenic ions, an obvious fluorescence change from faint yellow to green was observed visible to the naked eye. The probe can detect arsenic selectively in the presence of interfering substances, with a lower detection limit than 0.7 ppb, a value which is far lower than the limit set by the WHO. A detailed mechanism revealed that the chelation of TBAB with arsenic activated the AIE characteristic, leading to the enhanced fluorescence, which was verified by Job's plot experiment and HRMS. Its practicality was further validated by the analysis of real water samples, demonstrating its potential application for on-site detection and biological application.


Assuntos
Arsenitos , Corantes Fluorescentes , Humanos , Íons , Bases de Schiff , Espectrometria de Fluorescência/métodos
9.
Front Med (Lausanne) ; 8: 684058, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34239889

RESUMO

Objective: Several studies suggested that Qigong exercise (QE) can relieve fatigue in patients diagnosed with various diseases. Our review aimed to evaluate the efficacy of QE for alleviating fatigue. Methods: A related literature search was performed in the PubMed, Web of Science, Embase, Cochrane Library, China Biology Medicine disc (CBM), China National Knowledge Infrastructure (CNKI), Wanfang, and VIP data bases from inception to November 2020. Information on fatigue, malaise, tiredness, and Qigong research data was collected. Results: Sixteen randomized controlled trials (RCTs) were reported in patients with cancer (n = 4), chronic fatigue syndrome (n = 2), and other diseases (n = 10). The QE groups showed significant improvements in total fatigue intensity [15 RCTs, p < 0.00001; standard mean difference (SMD) -0.69 (-0.95 to -0.44)]. The QE groups did not show significant improvement in quality of life [4 RCTs, p = 0.08; SMD 0.53 (-0.07 to 1.14)]. The statistically significant difference of the subgroup analyses (different primary diseases, QE types, and study quality) also remained unchanged. Conclusion: The findings of this meta-analysis indicate that QE may be beneficial for improving fatigue in patients diagnosed with various diseases. Considering the limitations of the study, we draw a very cautious conclusion regarding the resulting estimate of the effect. Further studies are warranted to better understand the benefits of QE in primary medical care.

10.
Chem Commun (Camb) ; 57(54): 6608-6611, 2021 Jul 06.
Artigo em Inglês | MEDLINE | ID: mdl-34114574

RESUMO

We report a rational strategy to deliberately construct the first asymmetric tetraarylimidazole-based AIE probe, integrating AIE behavior in synergy with ESIPT character to image endogenous LAP for the first time. It offered good sensitivity and selectivity, and concomitantly, was applied successfully for real-time tracking of LAP in the cisplatin-induced liver injury zebrafish model.


Assuntos
Imidazóis/química , Leucil Aminopeptidase/metabolismo , Animais , Leucil Aminopeptidase/química , Fígado/metabolismo , Sondas Moleculares/química , Peixe-Zebra
11.
Medicine (Baltimore) ; 100(3): e23983, 2021 Jan 22.
Artigo em Inglês | MEDLINE | ID: mdl-33545986

RESUMO

BACKGROUND: About 5% to 20% of the general population suffers from continuous fatigue, which is also one of the most frequent symptoms seen in primary medical care. Fatigue, if not effectively relieved, may have an adverse effect on the quality of life and treatment of patients. Qigong is a safe and comfortable exercise popular in China and among the Ethnic Chinese, and is a complementary therapy used to treat fatigue, such as cancer related fatigue and chronic fatigue syndrome. It appears promising but lacks convincing evidence; thus, necessitating further investigation. METHODS: Eight databases (PubMed, Web of Science, Embase, Cochrane Library, China Biology Medicine disc, China National Knowledge Infrastructure, WanFang and VIP Data Knowledge Service Platform) will be searched from inception to November 30, 2020 for randomized controlled trials published in English or Chinese investigating the outcomes of the Qigong exercise (QE) for symptoms of fatigue and quality of life. We will also include additional references of relevant published studies by manually retrieving reference lists of included literature and previous relevant reviews. For articles that meet the inclusion criteria, 2 reviewers will independently conduct the study selection, data extraction, and risk of bias assessment. The results of the outcome measures will be reported in risk ratios for dichotomous data and standard mean differences for continuous data. If necessary, we will also perform subgroup analyses and analyze the causes. RESULTS: The results of this review will be submitted to a journal for publication. CONCLUSION: This systematic review protocol aims to analyze whether QE is effective in treating fatigue associated with various disease. REGISTRATION: INPLASY2020110133.


Assuntos
Terapia por Exercício/métodos , Fadiga/terapia , Qigong/métodos , Humanos , Metanálise como Assunto , Ensaios Clínicos Controlados Aleatórios como Assunto , Projetos de Pesquisa , Revisões Sistemáticas como Assunto , Resultado do Tratamento
12.
Talanta ; 225: 121950, 2021 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-33592705

RESUMO

Abnormal level of alkaline phosphatase (ALP) activity has been linked to many diseases in human. The development of fluorescent molecular probes that can report the expression and activity of ALP in various biological systems will be extremely valuable. However, the in vivo monitoring for ALP in living cells and more complex biological systems remains a great challenge. The excited-state intramolecular proton transfer (ESIPT) probe with proportional fluorescence has low background noise, while the aggregation induced emission (AIE) probe has the advantages of signal amplification and good light stability. Herein, an "AIE + ESIPT" fluorescent probe 2-(benzo[d]thiazol-2-yl)-4-(1,4,5-triphenyl-1H-imidazole-2-yl)phenyl dihydrogen phosphate (THP) was constructed for the highly selective and sensitive detection of ALP. By introducing a phosphate ester at the hydroxyl position of the solid fluorophore 2-(benzo[d]thiazol-2-yl)-4-(1,4,5-triphenyl-1H-imidazole-2-yl)phenol, ESIPT was hindered and the probe present a faint blue fluorescence in DMSO solution. While ALP was introduced, causing the phosphate in THP hydrolyzed, and the ESIPT process was restored to yield a yellow fluorescence at 550 nm, thereby achieving proportionality detection. THP exhibited high selectivity and sensitively to ALP with low limit of detection (1.21228 U/L), and the reaction completed within 20 min. In addition, with its outstanding advantages of low biological toxicity and enzyme conversion characteristics, THP has been successfully applied to ALP imaging in living cells (Hela cells, A549 cells and Hek293 cells), and can provide in situ information on the reaction site. Therefore, THP has the potential for detecting ALP activity in biomedical application.


Assuntos
Fosfatase Alcalina , Corantes Fluorescentes , Células HEK293 , Células HeLa , Humanos , Espectrometria de Fluorescência
13.
Bioorg Med Chem Lett ; 30(4): 126913, 2020 02 15.
Artigo em Inglês | MEDLINE | ID: mdl-31883693

RESUMO

To get chelidonine derivatives with enhanced antiproliferative activity and selectivity, a series of nitric oxide donating derivatives (10a-f and 11a-j) were designed, synthesized and biologically evaluated. Compared with chelidonine, these compounds exhibited lower IC50 values against human hepatoma cells HepG2, breast cancer cells MCF-7, colon cancer cells HCT-116, as well as leukemia cells K562. Compound 11j displayed the strongest antiproliferative activity with IC50 values of 3.91, 6.90, 4.36 and 1.12 µM against the above four cells, respectively. Nevertheless, it showed an IC50 value >40 µM against human peripheral blood mononuclear cells (PBMCs), which demonstrated high selectivity between normal and cancer blood cells. In further mechanism studies, 11j showed the capability to induce K562 cells apoptosis, S phase cell cycle arrest and mitochondrial membrane potential disorder. Besides, 11j was found to be effective in promoting the expression of proapoptotic protein Bad and suppressing the expression of anti-apoptotic proteins Bcl-xL, catalase, survivin, claspin and clusterin.


Assuntos
Antineoplásicos/síntese química , Benzofenantridinas/química , Desenho de Fármacos , Antineoplásicos/farmacologia , Apoptose/efeitos dos fármacos , Benzofenantridinas/farmacologia , Linhagem Celular Tumoral , Ensaios de Seleção de Medicamentos Antitumorais , Humanos , Leucócitos Mononucleares/citologia , Leucócitos Mononucleares/efeitos dos fármacos , Leucócitos Mononucleares/metabolismo , Potencial da Membrana Mitocondrial/efeitos dos fármacos , Óxido Nítrico/metabolismo , Pontos de Checagem da Fase S do Ciclo Celular/efeitos dos fármacos , Relação Estrutura-Atividade
14.
Fitoterapia ; 139: 104359, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31629049

RESUMO

Two new lignanamides, majusamides A and B (1 and 2), and two new alkaloids, chelidoniumine (3) and tetrahydrocoptisine N-oxide (4), together with six known hydroxycinnamic acid amides (HCCA) were isolated from the 75% ethanol extract of Chelidonium majus through the silica gel, Sephadex LH-20, MCI, ODS column chromatography, and semi-HPLC. Their structures were determined on the basis of spectroscopic data and physico-chemical methods. The absolute configurations of 1-3 were determined by electronic circular dichroism (ECD) calculations. The anti-inflammatory activities of all the isolates on the NO production in lipopolysaccharide (LPS)-induced macrophages were evaluated. Compounds 7 and 9 exhibited moderate inhibitory activity with IC50 values of 25.3 ±â€¯0.5 and 23.5 ±â€¯1.7 µM, respectively.


Assuntos
Alcaloides/farmacologia , Amidas/farmacologia , Anti-Inflamatórios/farmacologia , Chelidonium/química , Lignanas/farmacologia , Óxido Nítrico/metabolismo , Alcaloides/isolamento & purificação , Amidas/isolamento & purificação , Animais , Anti-Inflamatórios/isolamento & purificação , Linhagem Celular , China , Lignanas/isolamento & purificação , Camundongos , Microglia/efeitos dos fármacos , Estrutura Molecular , Compostos Fitoquímicos/isolamento & purificação , Compostos Fitoquímicos/farmacologia , Componentes Aéreos da Planta/química
15.
Nanoscale ; 11(16): 7825-7832, 2019 Apr 23.
Artigo em Inglês | MEDLINE | ID: mdl-30963146

RESUMO

Research into photocatalytic mechanisms and charge carrier transfer is of vital significance. For type-II heterostructures containing WO3, a visualizable means is proposed for the first time for verifying the manner of charge transfer via observing the photochromism of WO3. The accuracy of this visualizable means is evidenced through corresponding characterization, such as XPS and OCP. In addition, photocatalytic H2 evolution as a supporting proof is studied to prove the manner of charge transfer owing to the inactivity of WO3. If the charge transfer pathway principally follows a conventional type-II manner, the heterostructure will change color from yellow to a dark color and show lower activity compared with the individuals. However, if the charge transfer primarily follows a Z-scheme mechanism, the color won't show a noticeable change but much higher activity will be exhibited than that by the individual components. CdS-WO3 and ZnIn2S4-WO3 (ZIS-WO3) are used as examples to verify the universality of this method and exclude the impact of the crystal phase of WO3 on photochromism.

16.
Nanoscale ; 11(18): 9085-9090, 2019 May 09.
Artigo em Inglês | MEDLINE | ID: mdl-31026013

RESUMO

Ultrathin semiconductors have been proposed as an excellent platform to promote solar conversion due to their ultra-large specific surface area and unique surface structures. So far, the researchers designed and constructed some multi-component heterostructure photocatalysts, but they are still unable to avoid the recombination of photoexcited electron-hole pairs. This study introduces a built-in electric field in a one-component nanosheet to promote photo-generated carrier separation. For this reason, CdS nanosheets with both photocatalytic and piezoelectric properties were selected as research objects. The combination of these two properties renders CdS an excellent candidate for efficiently utilizing both light and vibrational energy for photocatalytic water splitting, without the need for coupling it to other materials or using an external bias. The result shows that the photocatalytic and piezoelectric coupling effect of CdS can make hydrogen production reach 633 µL h-1, which was more than twice the superposition of light and vibration. The development of this coupling effect contributes to the application of green energies, such as the use of natural sunlight and noise or vibration.

17.
J Agric Food Chem ; 67(8): 2377-2383, 2019 Feb 27.
Artigo em Inglês | MEDLINE | ID: mdl-30707026

RESUMO

Using Hg2+-induced umpolung reaction and aggregation induced emission (AIE), we have rationally developed a water-soluble fluorescent probe 2,2'-(((4-(4,5-bis(4-methoxyphenyl)-1-phenyl-1H-imidazol-2-yl)phenyl)methylene)bis(sulfanediyl))diethanol (MPIPBS) for Hg2+ detection. MPIPBS was found to have high selectivity and sensitivity toward Hg2+ detection. The mechanism of MPIPBS response to Hg2+ was verified by 1H NMR titration, HPLC, and HRMS spectroscopy. The detection limit was examined to be 1.45 nM, which is lower than most reported probes for Hg2+. Taking advantage of excellent optical properties of AIEgen, a paper based sensor for Hg2+ detection was fabricated by immobilizing the MPIPBS on Waterman test paper. Meanwhile, MPIPBS showed satisfactory analytical performance in real water and urine samples. Further, thanks to the high water solubility, cell membrane permeability and low cytotoxicity, MPIPBS was further used to detect Hg2+ both in living cells and zebrafish. We anticipate that the prepared probe was available to detect Hg2+ in environment and biosamples.


Assuntos
Corantes Fluorescentes/química , Mercúrio/análise , Espectrometria de Fluorescência/métodos , Poluentes Químicos da Água/análise , Animais , Células HeLa , Humanos , Limite de Detecção , Mercúrio/urina , Peixe-Zebra
18.
Anticancer Agents Med Chem ; 19(6): 720-730, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30747081

RESUMO

BACKGROUND: Cancer, as one of the most dangerous disease, causes millions of deaths every year. The main reason is the absence of an effective and thorough treatment. Drug delivery systems have significantly reduced the side-effect of chemotherapy. Combined with nanotechnology, smart drug delivery systems including many different nanoparticles can reduce the side-effect of chemotherapy better than traditional drug delivery systems. METHODS: In this article, we will describe in detail the different kinds of nanoparticles and their mechanisms emphasizing the triggering factors in drug delivery. Besides, the application of smart drug delivery systems in imaging will be introduced. RESULTS: Combined with nanotechnology, smart drug delivery systems including many different nanoparticles can reduce the side-effect of chemotherapy better than traditional drug delivery systems. CONCLUSION: Despite considerable progress in nanoparticle research over the past decade, such as smart drug delivery systems for the treatment of cancer, molecular imaging probes and the like. The range of nanoparticles used in multifunction systems for imaging and drug delivery continues to grow and we expect this dilatation to continue. But to make nanoparticles truly a series of clinical products to complement and replace current tools, constant exploration efforts and time are required. Overall, the future looks really bright.


Assuntos
Antineoplásicos/uso terapêutico , Sistemas de Liberação de Medicamentos , Nanomedicina , Nanopartículas/química , Neoplasias/tratamento farmacológico , Animais , Antineoplásicos/química , Humanos
19.
Fitoterapia ; 125: 235-239, 2018 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-29221703

RESUMO

Three new diterpenoids, ebractenoids O~Q (1-3), and a new phenolic glucoside, γ-pyrone-3-O-ß-d-(6-galloyl)-glucopyranoside (4), together with 6 known compounds, were isolated from the 95% ethanol extract of the roots of Euphorbia ebracteolata, and their structures were elucidated on the basis of spectroscopic data. The absolute configurations of 1-3 were determined by electronic circular dichroism (ECD) calculations. The inhibitory effects of all the isolates with exception of compounds 8 and 10 on the NO production in lipopolysaccharide (LPS)-induced macrophages were evaluated. All of them exhibited significant inhibitory activity.


Assuntos
Diterpenos/química , Euphorbia/química , Glucosídeos/química , Fenóis/química , Animais , Diterpenos/isolamento & purificação , Glucosídeos/isolamento & purificação , Lipopolissacarídeos , Macrófagos/efeitos dos fármacos , Camundongos , Estrutura Molecular , Óxido Nítrico/metabolismo , Fenóis/isolamento & purificação , Raízes de Plantas/química , Células RAW 264.7
20.
Chem Commun (Camb) ; 53(70): 9765-9768, 2017 Aug 29.
Artigo em Inglês | MEDLINE | ID: mdl-28813040

RESUMO

Under simultaneous full arc light and ultrasonic irradiation, photo-generated electrons are brought together by piezoelectric potential, and thus dense electrons induce the reduction of carbon dioxide on the surface of piezoelectric semiconductors, resulting in an improved selectivity of methane production to a greater degree.

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