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1.
Hong Kong Med J ; 14(1): 35-9, 2008 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-18239241

RESUMO

OBJECTIVE: To determine the factors associated with high-dose antipsychotic prescribing for psychiatric patients in Hong Kong. DESIGN: Retrospective cross-sectional study. SETTING: Psychiatric in-patients and out-patients in the New Territories West Cluster, Hong Kong. PATIENTS: A total of 1129 in-patients and 7520 out-patients who received antipsychotic medications on the study date. MAIN OUTCOME MEASURES: Demographic and clinical data were compared for patients receiving 'normal' and high dosages of antipsychotic medications. RESULTS: High dosages were prescribed for 104 (9.2%) of the in-patients and 137 (1.8%) of out-patients. Antipsychotic polypharmacy was the most powerful predictor of high-dose prescribing, with an odds ratio of 8.88 for in-patients and 10.82 for out-patients. CONCLUSION: Antipsychotic polypharmacy was the main determinant of high-dose antipsychotic prescribing in this study. Further studies should be conducted to look for other variables contributing to such prescribing in Hong Kong.


Assuntos
Antipsicóticos/administração & dosagem , Revisão de Uso de Medicamentos , Transtornos Mentais/tratamento farmacológico , Polimedicação , Padrões de Prática Médica/estatística & dados numéricos , Adulto , Fatores Etários , Feminino , Hong Kong , Humanos , Pacientes Internados , Masculino , Pessoa de Meia-Idade , Pacientes Ambulatoriais , Estudos Retrospectivos , Fatores Sexuais
2.
Hong Kong Med J ; 13(1): 73-4, 2007 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-17277396

RESUMO

We present a case report of a 22-year-old Chinese man with schizophrenia and dissocial personality disorder who was normoglycaemic before taking olanzapine. After commencing olanzapine he developed diabetic ketoacidosis and was managed in the intensive care unit of a general hospital. Olanzapine was stopped and replaced by haloperidol 5 mg/day. He was put on a strict 1500 kcal diabetic diet and required insulin injections to maintain a normal blood sugar level despite cessation of olanzapine for 4 months. Doctors prescribing olanzapine should be aware of the risk of diabetes mellitus. Baseline and regular monitoring of body weight, body mass index, and fasting blood glucose are essential to prevent serious consequences.


Assuntos
Antipsicóticos/efeitos adversos , Cetoacidose Diabética/induzido quimicamente , Adulto , Antipsicóticos/administração & dosagem , Benzodiazepinas/administração & dosagem , Benzodiazepinas/efeitos adversos , Cetoacidose Diabética/terapia , Dieta para Diabéticos , Hong Kong , Humanos , Hipoglicemiantes/uso terapêutico , Insulina/uso terapêutico , Masculino , Olanzapina , Esquizofrenia/tratamento farmacológico
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