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1.
J Mech Behav Biomed Mater ; 119: 104498, 2021 Mar 31.
Artigo em Inglês | MEDLINE | ID: mdl-33839538

RESUMO

OBJECTIVE: In this study, we incorporated hybrid nanoparticles (poly (acrylic acid)-grafted nanoclay/nanosilica, respectively, with platelet and spherical morphologies, abbreviated as PAA-g-NC-Sil) in different concentrations (0, 0.2, 0.5, 1, 2 and 5 wt%) to an experimental dentin bonding system and investigated the physical properties of the filled adhesive and its shear bond strength (µ-SBS) to dentin. We subsequently compared the properties of the adhesives containing PAA-g-NC-Sil with previously studied adhesives containing poly (methacrylic acid)-g-nanoclay (PMA-g-NC) (Solhi et al., 2012a), poly (acrylic acid)-g-nanoclay (PAA-g-NC) (Solhi et al., 2012b), and the hybrid poly (methacrylic acid)-grafted-nanoclay-nanosilica (PMA-g-NC-Sil) (Solhi et al., 2020). MATERIALS AND METHODS: In a set of previous publications and the present paper, we grafted poly (acrylic acid) (PAA) or poly (methacrylic acid) (PMA) onto the surface of pristine Na-MMT nanoclay (Cloisite® Na+) through free radical polymerization of monomer in an aqueous media in the presence or absence of nanosilica particles. We characterized the resulting modified nanoparticles (PMA-g-NC, PAA-g-NC, PMA-g-NC-Sil and PAA-g-NC-Sil) using GPC, FTIR, TGA, and XRD. We then incorporated the modified particles as functionalized fillers to experimental dentin adhesives in different concentrations and studied the stability of modified fillers dispersion by separation analysis. We also studied the properties of the photo-cured adhesive matrices using FTIR, TEM, SEM, EDXA, and XRD. We examined the shear bond strength of the adhesives (containing different contents of each modified filler, separately) to human premolar teeth. The results were analysed and compared statistically. RESULTS: The results confirmed that the polymers have been grafted onto the surface of nanoclay. An exfoliated structure for the nanoclay platelets in the photo-cured adhesive containing PAA-g-NC-Sil was observed. Addition of 0.5 wt% of PAA-g-NC-Sil to the experimental adhesive increased the shear bond strength and the dispersion stability in comparison to unfilled adhesive. The same trend was also observed for adhesives containing PMA-g-NC, PAA-g-NC, and PMA-g-NC-Sil. The adhesive containing PAA-g-NC-Sil showed the best dispersion stability and subsequently the highest shear bond strength in the optimal concentration among adhesives containing the four available fillers (PMA-g-NC, PAA-g-NC, PMA-g-NC-Sil and PAA-g-NC-Sil). SIGNIFICANCE: Addition of poly (acrylic acid) modified nanoparticles to the experimental dentin adhesives resulted in higher shear bond strength due to the potential interactions between the carboxylic acid functional groups on the surface of the modified particles and the dentin structure. Between the poly (acrylic acid) and poly (methacrylic acid), the former acid with higher PKa performed better. Addition of the spherical nanosilica particles to the adhesives containing platelet nanoclay helped to better exfoliate the platelets resulting in improved µ-SBS and dispersion stability.

2.
Gene ; 781: 145524, 2021 May 20.
Artigo em Inglês | MEDLINE | ID: mdl-33631241

RESUMO

BACKGROUND: Oral Cancer (OC) is one of the leading causes of death and the disease mainly occurs over 50 years of age. Herein, a meta-analysis aimed to assess the association between X-ray repair cross complementing (XRCC) polymorphisms and OC risk. METHODS: Four databases were searched extensively until June 5, 2020. Subgroup analysis, meta-regression, and funnel plots, as well as the quality assessment were estimated. RESULTS: Fifteen studies were entered to the analysis. With regards to allele, homozygote, heterozygote, recessive, and dominant models, the pooled ORs for XRCC1 rs1799782 polymorphism were 1.51 (P = 0.01), 1.45 (P = 0.11), 1.45 (P = 0.0003), 1.44 (P = 0.0002), and 1.29 (P = 0.26); for XRCC1 rs1799782 polymorphism were 1.65 (P = 0.11), 1.50 (P = 0.33), 1.06 (P = 0.83), 1.57 (P = 0.12), and 1.32 (P = 0.45); for XRCC1 rs25489 polymorphism were 0.01 (P = 0.19), 1.44 (P = 0.48), 1.21 (P = 0.72), 1.17 (P = 0.19), and 1.38 (P = 0.54); for XRCC2 rs2040639 polymorphism were 0.68 (P = 0.0002), 0.63 (P = 0.02), 0.95 (P = 0.92), 0.79 (P = 0.49), and 0.61 (P = 0.005); and for XRCC3 rs861539 polymorphism were 1.24 (P = 0.20), 1.28 (P = 0.48), 0.99 (P = 0.95), 1.15 (P = 0.46), and 1.52 (P = 0.15), respectively. CONCLUSIONS: The T allele and CT genotype of XRCC1 rs1799782 polymorphism had an elevated risk, whereas the G allele and GG genotype of XRCC2 rs2040639 polymorphism had a protective role in OC.


Assuntos
Reparo do DNA , Proteínas de Ligação a DNA/genética , Neoplasias Bucais/genética , Proteína 1 Complementadora Cruzada de Reparo de Raio-X/genética , Predisposição Genética para Doença , Humanos , Polimorfismo Genético
3.
Cleft Palate Craniofac J ; : 1055665620980606, 2020 Dec 17.
Artigo em Inglês | MEDLINE | ID: mdl-33334138

RESUMO

OBJECTIVES: Cleft lip and palate (CLP) is a congenital anomaly that affects not only the patients but also their family members and companions. Identifying the problems encountered by patients with CLP and their families can greatly help clinicians in efficient treatment planning to obviate the treatment needs and promote the quality of life of patients. This study aimed to determine the experiences of the parents of children with CLP undergoing orthodontic treatment. METHODS: This study was conducted based on descriptive phenomenology using the Colaizzi's 7-step analysis method of phenomenological data. The private orthodontic clinics of Kermanshah city were evaluated in this study. The participants included the parents of children with CLP younger than 15 years who had presented to the clinics seeking orthodontic treatment. In-depth semistructured interviews with open-ended questions were used to collect information regarding the experiences of parents in this process. The collected data were analyzed using the Colaizzi's 7-step analysis. RESULTS: Qualitative analysis of the interviews yielded 271 codes, 18 subthemes, 7 themes, and 3 main themes including fatigue (exhaustion, helplessness, and incompetence), self-reliance (mutual support and empathy), and the need for social support (counseling services and citizenship rights). CONCLUSION: In general, the results revealed that parents of children with CLP under orthodontic treatment are vulnerable due to their previous adverse experiences in the course of treatment of their children and need support in several physical, psychological, social and spiritual domains.

4.
Int Orthod ; 2020 Oct 31.
Artigo em Inglês | MEDLINE | ID: mdl-33144060

RESUMO

INTRODUCTION: This study aimed to assess the effect of different types of laser etching versus phosphoric acid etching on shear bond strength (SBS) of metal brackets to human enamel. MATERIALS AND METHODS: In this systematic review and meta-analysis, relevant articles published until the end of October 2019 were retrieved from PubMed, ISI Web of Science, Scopus, Embase, and Cochrane Library. The inclusion criteria were in vitro studies on the effect of laser on SBS of metal brackets to the enamel in comparison with acid-etching, and studies published in English to the end of October 2019. After assessing the eligibility criteria and quality, a total of 18 studies were statistically analysed using STATA software. RESULTS: The SBS of 554 human tooth specimens in the test group (subjected to irradiation of different laser types) was compared with the SBS of 313 tooth specimens in the control group (etched with phosphoric acid). The meta-analysis showed that laser etching decreased the SBS of brackets by 1.39MPa, compared with phosphoric acid etching, and this reduction was statistically significant (P<0.05). The Er:YAG group, however, showed 0.6MPa higher SBS than phosphoric acid etching group, but this increase was not statistically significant. CONCLUSION: Laser etching yields lower SBS than acid etching; even though different laser types have different effects on SBS. Thus, the conventional acid-etching technique is still recommended for enamel etching prior to the bonding of orthodontic metal brackets.

5.
Ann Otol Rhinol Laryngol ; : 3489420967698, 2020 Oct 28.
Artigo em Inglês | MEDLINE | ID: mdl-33111542

RESUMO

OBJECTIVES: Chronic rhinosinusitis (CRS) is a common chronic respiratory disorder. This study aimed to investigate the relation between nasal obstruction and sexual dysfunction in men with CRS. METHODS: In this case-control study, 100 married men aged 19 to 48 years with CRS and 56 healthy married men were selected, consecutively. For assessment of nasal obstruction severity NOSE scale (Nasal Obstruction Symptom Evaluation) was used and IIEF (International Index of Erectile Function) inventory was used to assess sexual function. RESULTS: Mean age of patients with CRS and controls was 33.25 ± 6.5 and 30.58 ± 7.12 years, respectively. Nasal obstruction was moderate in 70% of patients and 95% of patients had some degrees of erectile dysfunction. A significant association was found between nasal obstruction severity and sexual function and by increasing severity of nasal obstruction, sexual function decreased significantly in CRS patients. Sexual function in total (IIEF score) and in its domains, except for sexual desire, were significantly higher in control group (P < .05). CONCLUSION: There is significant inverse association between severity of nasal obstruction and sexual function. Sexual function decreases with increasing severity of nasal obstruction in CRS. CRS patients also have lower sexual function scores than healthy control males.

6.
BMC Med Educ ; 20(1): 287, 2020 Aug 31.
Artigo em Inglês | MEDLINE | ID: mdl-32867758

RESUMO

BACKGROUND: Considering the increasing popularity of electronic learning, particularly smartphone-based mobile learning, and its reportedly optimal efficacy for instruction of complicated topics, this study aimed to compare the efficacy of smartphone-based mobile learning versus lecture-based learning for instruction of cephalometric landmark identification. METHODS: This quasi-experimental interventional study evaluated 53 dental students (4th year) in two groups of intervention (n = 27; smartphone instruction using an application) and control (n = 26, traditional lecture-based instruction). Two weeks after the instructions, dental students were asked to identify four landmarks namely the posterior nasal spine (PNS), orbitale (Or), articulare (Ar) and gonion (Go) on lateral cephalograms. The mean coordinates of each landmark identified by orthodontists served as the reference point, and the mean distance from each identified point to the reference point was reported as the mean consistency while the standard deviation of this mean was reported as the precision of measurement. Data were analyzed using SPSS version 18 via independent sample t-test. RESULTS: No significant difference was noted between the two groups in identification of PNS, Ar or Go (P > 0.05). However, the mean error rate in identification of Or was significantly lower in smartphone group compared with the traditional learning group (P = 0.020). CONCLUSIONS: Smartphone-based mobile learning had a comparable, and even slightly superior, efficacy to lecture-based learning for instruction of cephalometric landmark identification, and may be considered, at least as an adjunct, to enhance the instruction of complicated topics. TRIAL REGISTRATION NUMBER: This is not a human subject research. https://ethics. RESEARCH: ac.ir/ProposalCertificateEn.php?id=33714&Print=true&NoPrintHeader=true&NoPrintFooter=true&NoPrintPageBorder=true&LetterPrint=true .

7.
8.
Front Immunol ; 11: 1343, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32793188

RESUMO

Obstructive sleep apnea syndrome (OSAS) is considered a low-grade chronic inflammatory disease. Interleukin-6 (IL-6) is one of the most significant inflammatory markers and an excellent proxy for the inflammatory/immune system. The present meta-analysis and meta-regression aimed at comparing plasma and serum levels of IL-6 between individuals (children and adults) with OSAS and healthy controls. Four databases, PubMed/Medline, Scopus, Cochrane Library, and Web of Science, were comprehensively searched to retrieve articles published up to December, 2019, with no further restrictions. RevMan 5.3 software was used to calculate the crude mean difference (MD) and 95% confidence interval (CI). The results of funnel plots and meta-regression were analyzed by the CMA 2.0 software. Sixty-three studies (57 with adults; six with children) were included in the present meta-analysis. For adults, 37 studies reported significantly higher serum IL-6 levels and 20 reported significantly higher plasma IL-6 levels for those with OSAS than for healthy controls [pooled MD of 2.89 pg/ml (P < 0.00001) and pooled MD of 2.89 pg/ml (P < 0.00001), respectively]. The pooled analysis of serum and plasma IL-6 levels in children with OSAS compared with controls revealed that only the MD of plasma IL-6 levels was significant (MD = 0.84 pg/ml, P = 0.004). Results of the meta-regression showed that greater age was associated with higher serum IL-6 levels. Egger's test revealed a publication bias across the studies for serum and plasma IL-6 levels (P = 0.00044 and P = 0.01445, respectively). In summary, the meta-analysis and meta-regression confirmed that, compared to healthy controls, individuals with OSAS (children and adults) had higher serum/plasma IL-6 levels.

9.
Front Microbiol ; 11: 1019, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32508800

RESUMO

Biosynthesis of nanoparticles (NPs) by microorganisms is a cost- and energy-effective approach. However, how the production of NPs affects the population of producing organism remains as an unresolved question. The present study aimed to evaluate the kinetics of Saccharomyces cerevisiae growth in relation to synthesis of selenium sulfide nanoparticles by using a population model. To this end, the population of S. cerevisiae cells was investigated in terms of colony forming units (CFU) in the presence of the substrate in different time points. Fluctuation of sulfite reductase (SiR) activity, expression of MET5 and MET10 genes, and concentrations of sulfite and selenium were evaluated to support the population findings. CFU values in the test groups were lower than those in the control counterparts. The rise and fall of the SiR activity and MET5 and MET10 gene expression conformed to the variations of CFU values. The rate of reduction in the selenium and sulfite concentrations tended to decrease over the time. In conclusion, the cells population was negatively and positively affected by selenium and sulfite concentrations, respectively. The indirect relationship of the selenium ions concentration in the path analysis revealed that the product, selenium sulfide nanoparticles, caused this drop in S. cerevisiae cells population.

10.
Life (Basel) ; 10(6)2020 Jun 12.
Artigo em Inglês | MEDLINE | ID: mdl-32545460

RESUMO

BACKGROUND: Obstructive sleep apnea syndrome (OSAS) is associated with a variety of inflammatory factors. Specifically, proinflammatory cytokines appear to be associated with the pathogenesis of OSAS. METHODS: For the present meta-analysis and meta-regression on serum and plasma tumor necrosis factor alpha (TNF-α) levels in individuals with and without OSAS, we performed a systematic search without any restrictions of the PubMed/Medline, Scopus, Cochrane Library, and Web of Science databases to find relevant articles published up to February 1, 2020. RESULTS: Fifty-five (adults: 29 studies on serum and 17 studies on plasma; children: 4 studies on serum and 5 studies on plasma) were included and analyzed. Always compared to age-matched healthy controls, the pooled MDs were as follows: adults, serum: 10.22 pg/mL (95% CI = 8.86, 11.58; p < 0.00001); adults, plasma: 5.90 pg/mL (95% CI = 4.00, 7.80; p < 0.00001); children, serum: 0.21 pg/mL (95% CI = 0.05, 0.37; p = 0.01); children, plasma: 5.90 pg/mL (95% CI = 4.00, 7.80; p < 0.00001). CONCLUSIONS: Compared to healthy and age-matched controls, adult individuals with OSAS had significantly higher serum/plasma TNF-α levels. For children with OSAS, significantly higher levels were observed for TNF-α in serum but not in plasma.

11.
J Mech Behav Biomed Mater ; 109: 103840, 2020 09.
Artigo em Inglês | MEDLINE | ID: mdl-32543405

RESUMO

OBJECTIVE: In this study the mechanical and adhesion properties of an experimental methacrylate based dentin bonding system containing a combination of spherical and layered platelet nanoparticles were investigated. The nanoparticles were first modified through surface graft polymerization of methacrylic acid in order to make the particles surface compatible with the bonding matrix resin. MATERIALS AND METHODS: Graft free radical polymerization in aqueous media was performed to attach Poly (methacrylic acid) (PMA) chains onto the surface of Na-MMT nanoclay (Cloisite® Na+) and silica nanoparticles (Aerosil® 200). The hybrid PMA grafted nanoparticles (PMA-g-NC-Sil) were characterized using GPC, FTIR, TGA, and X-ray diffraction (XRD). Dentin adhesives containing different amounts of the hybrid modified nanoparticles were photopolymerized and their characteristics were studied using FTIR, TEM, SEM, EDXA, and XRD techniques. The adhesives containing different amounts of PMA-g-NC-Sil were applied to the conditioned human premolar dentin to bond a dental composite to the teeth. The bond strength was then measured by microshear bond strength testing method. The results were analyzed and compared statistically. The stability of PMA-g-NC-Sil dispersion in the dentin adhesive was investigated using separation analysis (LUMi Reader) techniques. RESULTS: The grafting of PMA chains onto the surface of nanoclay was confirmed by FTIR and TGA analytical techniques. The intercalated-exfoliated structure for the nanoclay platelets in the photo-cured adhesive was observed using XRD and TEM. The surface modification of the nanoparticles significantly increased the dispersion stability of the fillers in the adhesive solution. The microshear test results indicated that the incorporation of the PMA-g-NC-Sil nanoparticles significantly enhanced the bond strength to dentin with the highest shear bond strength observed at 0.5 wt%. SIGNIFICANCE: The incorporation of the PMA modified hybrid nanofillers into the dentin adhesive resulted in a dentin bonding agent with enhanced shear bond strength through reinforcing the adhesive matrix and potential interactions between their carboxylic acid groups and the tooth structure. The dispersion stability of the nanoparticles was also dramatically improved by the surface modification of the nanoparticles.

12.
Am J Orthod Dentofacial Orthop ; 158(1): 75-83, 2020 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-32381435

RESUMO

INTRODUCTION: Achieving a balanced, attractive smile is an important goal in contemporary orthodontics. This study aimed to assess the smile attractiveness of Persian women after orthodontic treatment. METHODS: In this descriptive-analytical study, frontal-view photographs were taken of posed smiles of 100 Persian women 3 months after completion of their orthodontic treatment. A total of 153 laypeople aged over 15 years were requested to score each smile in terms of attractiveness using a visual analogue scale (1-10). Next, 25 photographs that acquired the lowest score (group A) and 25 photographs that acquired the highest score (group B) were chosen and evaluated by 3 orthodontists regarding parameters related to an attractive smile. Data were analyzed using SPSS version 18. RESULTS: The mean buccal corridor space in group A was significantly greater than that in group B (P = 0.004). The correlation of lip line and study group was significant such that 60% of patients in group B had a moderate lip line (P = 0.005). The difference in other parameters was not significant between the 2 groups (P >0.05). CONCLUSIONS: The buccal corridor space and lip line are important factors affecting smile attractiveness of Persian women. According to the opinion of the laypeople, smaller buccal corridor space and moderate lip line yield a more attractive smile. Thus, these parameters should be taken into account in the orthodontic treatment of Persian women.


Assuntos
Estética Dentária , Ortodontia , Adolescente , Assistência Odontológica , Feminino , Humanos , Lábio , Sorriso
13.
BMC Oral Health ; 20(1): 132, 2020 05 06.
Artigo em Inglês | MEDLINE | ID: mdl-32375748

RESUMO

BACKGROUND: This meta-analysis evaluated the association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility. METHODS: We searched the Scopus, PubMed/Medline, Web of Science, and Cochrane Library databases to retrieve articles published by October 2019. Review Manager 5.3 software was used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs). The results of publication bias tests were retrieved by Comprehensive Meta-Analysis 2.0 software. RESULTS: A total of 150 relevant records were identified; out of which, 16 were entered into the analysis (4 studies assessed LTF, 11 ENAM, and 11 AMELX polymorphisms). Of all polymorphisms, there was a significant association only between ENAM rs3796704 polymorphism and dental caries susceptibility. Both ENAM rs3796704 and AMELX rs17878486 polymorphisms had a significant association with dental caries risk in the Caucasian ethnicity and the studies including caries-free control group. CONCLUSIONS: The results of this meta-analysis showed that the G allele and the GG genotype of ENAM rs3796704 were associated with an increased risk of caries in the case group compared with the control group. But there was no association between LTF rs1126478, ENAM (rs1264848 and rs3796703), and AMELX (rs946252, rs17878486, and rs2106416) polymorphisms and dental caries susceptibility.


Assuntos
Amelogenina/genética , Suscetibilidade à Cárie Dentária/genética , Cárie Dentária/genética , Proteínas da Matriz Extracelular/genética , Lactoferrina/genética , Polimorfismo de Nucleotídeo Único/genética , Predisposição Genética para Doença/genética , Genótipo , Humanos
14.
Int J Biol Macromol ; 158: 477-485, 2020 Apr 09.
Artigo em Inglês | MEDLINE | ID: mdl-32278598

RESUMO

Increased multidrug resistant (MDR) bacteria are considered one of the most challenging problems of the present century. The present study aimed to identify the optimum conditions for synthesis of Polyhydroxybutyrate-Co3O4 bionanocomposite with the highest antibacterial activity via in situ synthesis. Nine experiments with different amounts of polyhydroxybutyrate (PHB) biopolymer and Co3O4 nanoparticles and different stirring times were designed using Taguchi method. The antibacterial activity of synthesized nanocomposites against Staphylococcus aureus and Escherichia coli was evaluated using colony forming units (CFU) and disc diffusion methods. The characterizations of products were studied by Fourier transform infrared spectroscopy (FTIR), ultraviolet-visible spectroscopy (UV-vis), X-ray powder diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), transmission electron microscopy (TEM), thermogravimetric analysis (TGA) and differential thermal analysis (DTA). The synthesized bionanocomposites completely prevented the growth of bacteria under the conditions of experiments 5 (Co3O4 4 mg/ml, PHB 1 mg/ml and stirring time: 90 min) and 9 (Co3O4 8 mg/ml, PHB 2 mg/ml and stirring time: 60 min). The results showed that nanocomposite formation improved structural properties, thermal stability and antibacterial activity. PHB-Co3O4 bionanocomposite can be used in various fields of pharmacy, medicine and dentistry due to its desirable antibacterial properties.

15.
Int Orthod ; 18(2): 214-224, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32241631

RESUMO

INTRODUCTION: This study aimed to evaluate the effect of bleaching with carbamide peroxide (CP) according to different doses and intervals between bleaching and bonding on shear bond strength (SBS) of orthodontic brackets. METHODS: Cochrane Central Register of Controlled Trials, the Cochrane Database of Systematic Reviews, PubMed, and Scopus were searched for articles published up to June 2018. After removing the duplicates, two of the authors screened the titles and abstracts independently. Assessing the eligibility of the selected full texts was also conducted by two of the authors independently. Disagreements were resolved by discussion. Modified version of Cochrane's risk of bias tool was used to assess the quality of studies. Fifteen studies were selected. RESULTS: Overall, bleaching with CP decreased the SBS by around 2MPa (P<0.0001). Using 10% CP decreased the SBS of the immediately bonded brackets by 5.13MPa (P<0.005). This value was 1.67MPa when the bonding procedure was postponed by one day (P<0.0001). Postponing the bonding procedure for longer periods did not cause a statistically significant change in SBS. Using 11-16% CP, the reduction in SBS of the immediately bonded brackets was 8.51MPa (P<0.01). The SBS decreased by 4.12MPa when the bonding procedure was postponed for 20days (P<0.05). According to one study, use of CP with>16% concentration seemed not to affect the SBS. CONCLUSIONS: Bleaching with CP decreases the SBS, especially if the bracket bonding is performed shortly after bleaching. However, given the small number of articles interpretation should be made with caution.

16.
IEEE Trans Neural Syst Rehabil Eng ; 28(5): 1059-1068, 2020 05.
Artigo em Inglês | MEDLINE | ID: mdl-32175866

RESUMO

One of the appealing cases of the neuromorphic research area is the implementation of biological neural networks. The current study offers Multiplierless Hodgkin-Huxley Model (MHHM). This modified model may reproduce various spiking behaviors, like the biological HH neurons, with high accuracy. The presented modified model, in comparison to the original HH model, due to its exact similarity to the original model, has more top performances in the case of FPGA saving and more achievable frequency (speed-up). In this approach, the proposed model has a 69 % saving in FPGA resources and also the maximum frequency of 85 MHz that is more than other similar works. In this modification, all spiking behaviors of the original model have been generated with low error calculations. To validate the MHHM neuron, this proposed model has been implemented on digital hardware FPGA. This approach demonstrates that the original HH model and the proposed model have high similarity in terms of higher performance and digital hardware cost reduction.

17.
Int Orthod ; 18(2): 191-202, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32146124

RESUMO

OBJECTIVE: The present meta-analysis is intended to assess the association between NSCL/P risk and methylenetetrahydrofolate reductase (MTHFR) A1298C polymorphism in case-control studies. MATERIALS AND METHODS: The Web of Science, PubMed/Medline, Scopus, and Cochrane Library databases were searched for related articles published by April 2019. Review Manager 5.3 was applied to measure the odds ratios (ORs) with 95% confidence interval (CI) in the analyses assessing the strength of the association between A1298C polymorphism and NSCL/P risk. Results Sixteen studies were involved and analysed in this meta-analysis. Altogether, the reviewed articles included 2677 NSCL/P patients and 3669 controls. The pooled ORs of the allele, homozygote, heterozygote, dominant, and recessive models were 1.11 (95% CI: 0.94, 1.30; P=0.21), 1.14 (95% CI: 0.94, 1.37; P=0.18), 0.98 (95% CI: 0.80, 1.20; P=0.87), 1.03 (95% CI: 0.86, 1.22; P=0.79), and 1.18 (95% CI: 0.99, 1.41; P=0.07), respectively. The analysis did not identify any significant association between the polymorphism and the risk of NSCL/P in any ethnicity or source of controls. CONCLUSIONS: This meta-analysis revealed that A1298C polymorphism is not associated with NSCL/P susceptibility, and the subgroup analyses based on ethnicity and the source of cases further confirmed this result.

18.
BMC Pulm Med ; 20(1): 31, 2020 Feb 05.
Artigo em Inglês | MEDLINE | ID: mdl-32024492

RESUMO

BACKGROUND: Obstructive sleep apnea syndrome (OSAS) is a common disorder that is accompanied by structural brain changes. This meta-analysis aimed to evaluate the effect of OSAS on the serum levels of astrocytic protein (S100B) and neuron-specific enolase (NSE) in observational studies. METHODS: A comprehensive search was performed in the PubMed/Medline, Web of Science, Scopus, ScienceDirect, and Cochrane Library databases to assess the serum level of S100B and/or NSE in patients with OSAS and/or controls. The quality of the study was evaluated by the Newcastle-Ottawa Scale (NOS). A random-effects model was performed using RevMan 5.3 with the mean difference (MD) and 95% confidence intervals (CIs). RESULTS: Out of 63 studies found in the mentioned databases and one identified by a manual search, nine studies were included and analyzed in this meta-analysis (three cross-sectional and six case-control studies). The analysis showed that the S100B [MD = 53.58 pg/ml, 95%CI: 1.81, 105.35; P = 0.04] and NSE levels [MD = 3.78 ng/ml, 95%CI: 2.07, 5.48; P < 0.0001] were significantly higher in patients than the controls. However, there were no significant differences between the S100B [MD = -28.00 pg/ml, 95%CI: - 79.48, 23.47; P = 0.29] and NSE levels [MD = 0.49 ng/ml, 95%CI: - 0.82, 1.80; P = 0.46]. CONCLUSIONS: This meta-analysis found elevated serum S100B and NSE levels in OSAS patients compared to the controls, which suggests that these markers may be used as peripheral indicators of brain damage in OSAS.


Assuntos
Dano Encefálico Crônico/sangue , Fosfopiruvato Hidratase/sangue , Subunidade beta da Proteína Ligante de Cálcio S100/sangue , Apneia Obstrutiva do Sono/sangue , Biomarcadores/sangue , Humanos , Estudos Observacionais como Assunto
19.
Sci Rep ; 10(1): 1531, 2020 01 30.
Artigo em Inglês | MEDLINE | ID: mdl-32001764

RESUMO

Both genetic and environmental factors affect the risk of orofacial clefts. The present meta-analysis aimed to evaluate the association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and risk of nonsyndromic cleft lip/palate (NSCL/P) in cases-control studies. The PubMed/Medline, Scopus, Web of Science, and Cochrane Library databases were searched up to April 2019 with no restrictions. The odds ratios (ORs) and 95% confidence intervals (CIs) in all analyses were calculated by Review Manager 5.3 software. The funnel plot analysis was carried out by the Comprehensive Meta-Analysis version 2.0 software. Subgroup analysis, meta-regression, and sensitivity analysis were performed for the pooled analyses. Thirty-one studies reviewed in this meta-analysis included 4710 NSCL/P patients and 7271 controls. There was no significant association between MTHFR C677T polymorphism and NSCL/P susceptibility related to allelic model (OR = 1.04; P = 0.49), homozygote model (OR = 1.11; P = 0.35), heterozygote model (OR = 0.99; P = 0.91), dominant model (OR = 1.00; P = 0.96), or recessive model (OR = 1.08; P = 0.23). There was no significant association between MTHFR C677T polymorphism and NSCL/P susceptibility based on the ethnicity or the source of cases. There was a significant linear relationship between the year of publication and log ORs for the allele model. The results of the present meta-analysis failed to show an association between MTHFR C677T polymorphism and NSCL/P susceptibility. The subgroup analyses based on the ethnicity and the source of cases further confirmed this result.


Assuntos
Fenda Labial/genética , Fissura Palatina/genética , Metilenotetra-Hidrofolato Redutase (NADPH2)/genética , Alelos , Frequência do Gene/genética , Predisposição Genética para Doença , Genótipo , Humanos , Metilenotetra-Hidrofolato Redutase (NADPH2)/metabolismo , Polimorfismo de Nucleotídeo Único/genética , Fatores de Risco
20.
Int J Pharm ; 577: 119037, 2020 Mar 15.
Artigo em Inglês | MEDLINE | ID: mdl-31953081

RESUMO

Spinal Cord Injury (SCI) is one of the leading causes of physical disability. In this study, spherical PLGA nanoparticles (NPs) containing ChABC enzyme were manufactured and fully characterized for SCI therapy. The NPs were used in the rat's contused spinal cord to assess the functional improvement and scar digestion. Twenty-three adult male Wistar rats (275 ± 25 g) were assigned into four groups of control, sham, blank-treated particle, and ChABC-treated particle. Throughout the survey, the BBB scores were obtained for all the groups. Finally, the injured sections of animals were dissected, and histological studies were conducted using Luxol fast blue and Bielschowsky. The biocompatibility and non-toxicity effects of the NPs on olfactory ensheathing cells (OECs) were confirmed by the MTT test. The flow-cytometry revealed the purity of cultured OECs with p75+/GFAP+ at around 87.9 ± 2.4%. Animals in the control and the blank-treated groups exhibited significantly lower BBB scores compared with the ChABC-treated particle group. Histological results confirmed the induced contusion models in the injured site. Myelin was observed in the treated groups, especially when the ChABC-loaded nanoparticles were utilized. The immunohistochemistry results indicated the scar glial degradation in animals treated by the ChABC-loaded particles. According to this study, the loaded particles can potentially serve as a suitable candidate for spinal cord repair, functional recovery and axonal regeneration.

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