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Mol Chem Neuropathol ; 28(1-3): 237-43, May-Aug. 1996.
Artigo em Inglês | MedCarib | ID: med-2381


Reports of an 18-fold higher incidence of schizophrenia among second-generation Afro-Caribbeans, and especially Jamaican migrants in the United Kingdom were soon called an epidemic of schizophrenia, with the inference that a novel virus, likely to be perinatally transmitted, was a possible etiological agent. This intriguing observation led us to explore a possible link with human T-cell lympotropic virus type one (HTLV-I), because it is a virus that is endemic in the Caribbean Island, is perinatally transmitted, known to be neuropathogenic, and the cause of a chronic myelopathy tropical spastic paraparesis/HTLV-I associated myelopathy. We therefore examined inpatients as the Bellevue Mental Hospital, Kingston, Jamaica and did standard serological tests for retroviruses HTLV-I and HTLV-II and HIV-I and HIV-II on 201 inpatients who fulfilled ICD-9 and DSM II-R criteria for schizophrenia. Our results produced important negative data, since the seropositivity rates for HTLV-I, the most likely pathogen, were no greater than the seropositivity range for HTLV-I carriers in this island population, indicating the HTLV-I and the other retroviruses tested do not play a primary etiological role in Jamaican schizophrenics(AU)

Pessoa de Meia-Idade , Adulto , Feminino , Humanos , Masculino , Retroviridae/isolamento & purificação , Esquizofrenia/virologia , Esquizofrenia/epidemiologia , Anticorpos Antivirais/sangue , Reino Unido/epidemiologia , HIV-1/isolamento & purificação , HIV-2/isolamento & purificação , Vírus Linfotrópico T Tipo 1 Humano/isolamento & purificação , Vírus Linfotrópico T Tipo 2 Humano/isolamento & purificação , Imunoglobulina G/sangue , Incidência , Jamaica/epidemiologia , Jamaica/etnologia , Classe Social