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1.
Artigo em Inglês | MEDLINE | ID: mdl-33466244

RESUMO

Although some studies showed that lifestyle was associated with oral health behavior, few studies investigated the association between household type and oral health behavior. The aim of this prospective cohort study was to investigate the association between household type, oral health behavior, and periodontal status among Japanese university students. Data were obtained from 377 students who received oral examinations and self-questionnaires in 2016 and 2019. We assessed periodontal status using the percentage of bleeding on probing (%BOP), probing pocket depth, oral hygiene status, oral health behaviors, and related factors. We used structural equation modeling to determine the association between household type, oral health behaviors, gingivitis, and periodontitis. At follow-up, 252 students did not live with their families. The mean ± standard deviation of %BOP was 35.5 ± 24.7 at baseline and 32.1 ± 25.3 at follow-up. In the final model, students living with their families were significantly more likely to receive regular dental checkup than those living alone. Regular checkup affected the decrease in calculus. The decrease in calculus affected the decrease in %BOP over 3 years. Living with family was directly associated with regular dental checkups and indirectly contributed to gingival status among Japanese university students.

2.
J Clin Periodontol ; 2021 Jan 23.
Artigo em Inglês | MEDLINE | ID: mdl-33484572

RESUMO

AIM: The purpose of this pilot prospective cohort study was to investigate the effects of parafunctional masseter muscle activity on periodontitis progression among patients receiving supporting periodontal therapy (SPT). MATERIALS AND METHODS: We collected data of patients treated at Okayama University Hospital from August 2014 to September 2018. The progression group was defined as patients with ≥2 teeth demonstrating a longitudinal loss of proximal attachment of ≥3 mm during the 3-year study period and/or at least one tooth extraction due to periodontitis progression. Surface electromyography of masseter muscles at baseline was continuously recorded while patients were awake and asleep. RESULTS: We analysed 48 patients (36 females) aged 66.8 ± 9.1 years (mean ± SD). The rate of parafunctional masseter muscle activity during waking hours and sleeping hours at baseline was 60.4% and 52.1%, respectively. Cox's proportional hazards regression model showed that the incidence of periodontitis progression was significantly associated with number of teeth present (p = 0.001) and parafunctional masseter muscle activity during waking hours (p = 0.041). CONCLUSION: Our results suggest that parafunctional masseter muscle activity during waking hours is a risk factor for periodontitis progression among patients receiving SPT.

3.
Artigo em Inglês | MEDLINE | ID: mdl-33233610

RESUMO

The long-term effects of secondhand smoke (SHS) on dental caries among Japanese young adults remain unclear. The purpose of this cross-sectional study was to evaluate whether household exposure to SHS is associated with dental caries in permanent dentition among Japanese young adults. The study sample included 1905 first-year university students (age range: 18-19 years) who answered a questionnaire and participated in oral examinations. The degree of household exposure to SHS was categorized into four levels according to the SHS duration: no experience (-), past, current SHS < 10 years, and current SHS ≥ 10 years. Dental caries are expressed as the total number of decayed, missing, and filled teeth (DMFT) score. The relationships between SHS and dental caries were determined by logistic regression analysis. DMFT scores (median (25th percentile, 75th percentile)) were significantly higher in the current SHS ≥ 10 years (median: 1.0 (0.0, 3.0)) than in the SHS-(median: 0.0 (0.0, 2.0)); p = 0.001). DMFT ≥ 1 was significantly associated with SHS ≥ 10 years (adjusted odds ratio: 1.50, 95% confidence interval: 1.20-1.87, p < 0.001). Long-term exposure to SHS (≥10 years) was associated with dental caries in permanent dentition among Japanese young adults.

4.
Hum Exp Toxicol ; : 960327120966040, 2020 Oct 16.
Artigo em Inglês | MEDLINE | ID: mdl-33063558

RESUMO

Arsenic, a major environmental toxicant and pollutant, is a global public health concern. Among its many adverse effects, arsenic is immunotoxic, but its effects on human neutrophil functions are not yet well-defined. In this study, we aimed to evaluate the in vitro effects of acute low-dose NaAsO2 exposure on human polymorphonuclear neutrophils (PMNs) for 12 h on the following innate defense mechanisms: formation of neutrophil extracellular traps (NETs), production of reactive oxygen species (ROS), and phagocytosis. Phorbol myristate acetate (PMA) was added to induce NETs formation, which was quantified by measuring cell-free extracellular DNA (cf-DNA), myeloperoxidase-conjugated (MPO)-DNA and neutrophil elastase-conjugated (NE)-DNA, and confirmed by immunofluorescence labeling and imaging. Extracellular bactericidal activity by NETs was evaluated by co-culturing Escherichia coli and PMNs in the presence of a phagocytic inhibitor. Levels of NETs in the culture medium after PMA stimulation was significantly lower in PMNs pre-exposed to arsenic than those not exposed to arsenic. Immunofluorescence staining and extracellular bactericidal activity by NETs revealed similar results. Phagocytosis and ROS production by PMNs were also significantly reduced by arsenic pre-exposure. Together, our findings provide new insights in arsenic immunotoxicity and suggest how it increases susceptibility to infectious diseases in humans.

5.
PLoS One ; 15(7): e0236259, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32702010

RESUMO

The aim of this prospective cohort study was to examine whether oral hygiene knowledge, and the source of that knowledge, affect oral hygiene behavior in university students in Japan. An oral exam and questionnaire survey developed to evaluate oral hygiene knowledge, the source of that knowledge, and oral hygiene behavior, such as the frequency of tooth brushing and regular dental checkups and the use of dental floss, was conducted on university student volunteers. In total, 310 students with poor tooth brushing behavior (frequency of tooth brushing per day [≤ once]), 1,963 who did not use dental floss, and 1,882 who did not receive regular dental checkup during the past year were selected. Among these students, 50, 364, and 343 in each respective category were analyzed in over the 3-year study period (follow-up rates: 16.1%, 18.5%, and 18.2%, respectively). The odds ratios (ORs) and 95% confidence intervals (CIs) for oral hygiene behavior were calculated based on oral hygiene knowledge and the source of that knowledge using logistic regression models. The results showed that dental clinics were the most common (> 50%) source of oral hygiene knowledge, and that a more frequent use of dental floss was significantly associated with dental clinics being a source of oral hygiene knowledge (OR, 4.11; 95%CI, 1.871-9.029; p < 0.001). In addition, a significant association was seen between dental clinics being a source of oral hygiene knowledge and more frequent regular dental checkups (OR, 13.626; 95%CI, 5.971-31.095; p < 0.001). These findings suggest the existence of a relationship between dental clinics being the most common source of oral hygiene knowledge and improved oral hygiene behavior in Japanese university students.


Assuntos
Comportamentos Relacionados com a Saúde , Conhecimentos, Atitudes e Prática em Saúde , Higiene Bucal , Estudantes , Universidades , Adolescente , Estudos de Coortes , Dispositivos para o Cuidado Bucal Domiciliar , Feminino , Seguimentos , Humanos , Japão , Masculino , Razão de Chances , Escovação Dentária
6.
Artigo em Inglês | MEDLINE | ID: mdl-32466124

RESUMO

The purpose of this 3-year prospective cohort study was to explore the relationship between an increase in dental caries and oral microbiome among Japanese university students. We analyzed 487 students who volunteered to receive oral examinations and answer baseline (2013) and follow-up (2016) questionnaires. Of these students, salivary samples were randomly collected from 55 students at follow-up and analyzed using next-generation sequencing. Students were divided into two groups: increased group (Δdecayed, missing, and filled teeth (ΔDMFT) score increased during the 3-year period) and non-increased group (ΔDMFT did not increase). Thirteen phyla, 21 classes, 32 orders, 48 families, 72 genera, and 156 species were identified. Microbial diversity in the increased group (n = 14) was similar to that in the non-increased group (n = 41). Relative abundances of the family Prevotellaceae (p = 0.007) and genera Alloprevotella (p = 0.007) and Dialister (p = 0.039) were enriched in the increased group compared with the non-increased group. Some bacterial taxonomic clades were differentially present between the two groups. These results may contribute to the development of new dental caries prevention strategies, including the development of detection kits and enlightenment activities for these bacteria.


Assuntos
Cárie Dentária , Microbiota , Adolescente , Bactérias , Feminino , Humanos , Masculino , Boca/microbiologia , Estudos Prospectivos , Saliva , Estudantes , Universidades , Adulto Jovem
7.
Artigo em Inglês | MEDLINE | ID: mdl-32349308

RESUMO

The purpose of this cross-sectional study was to investigate the association between sleep quality and duration, and periodontal disease among a group of young Japanese university students. First-year students (n = 1934) at Okayama University who voluntarily underwent oral health examinations were included in the analysis. Sleep quality and duration were assessed by the Japanese version of the Pittsburgh Sleep Quality Index. Dentists examined Oral Hygiene Index-Simplified (OHI-S), probing pocket depth (PPD), and percentage of sites with bleeding on probing (BOP). Periodontal disease was defined as presence of PPD ≥ 4 mm and BOP ≥ 30%. Overall, 283 (14.6%) students had periodontal disease. Poor sleep quality was observed among 372 (19.2%) students. Mean (± standard deviation) sleep duration was 7.1 ± 1.1 (hours/night). In the logistic regression analysis, periodontal disease was significantly associated with OHI-S (odds ratio [OR]: 2.30, 95% confident interval [CI]: 1.83-2.90; p < 0.001), but not sleep quality (OR: 1.09, 95% CI: 0.79-1.53; p = 0.577) or sleep duration (OR: 0.98, CI: 0.87-1.10; p = 0.717). In conclusion, sleep quality and duration were not associated with periodontal disease among this group of young Japanese university students.


Assuntos
Doenças Periodontais , Transtornos do Sono-Vigília , Sono , Estudos Transversais , Feminino , Humanos , Masculino , Doenças Periodontais/complicações , Transtornos do Sono-Vigília/complicações , Estudantes , Universidades
8.
Environ Sci Pollut Res Int ; 27(14): 16426-16438, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-32124307

RESUMO

The giant freshwater prawn, Macrobrachium rosenbergii, is an important species for Bangladesh's national economy, aquatic biodiversity, and employment opportunities; furthermore, human health risk associated to consumption of this species has become a crucial issue. Eight trace metals (Pb, Cr, Ni, Cd, Fe, Cu, Zn, and Mn) in different body parts of M. rosenbergii (U/10 as large and U/12 and U/15 as medium size), and water collected from farm and wild sources along with the human health risks were assessed in this study. Except Cd, all trace metals exceeded the maximum permissible limits proposed by different authorities. Elevated levels of Pb, Cr, Fe, Cu, Zn, and Mn were found in the wild-caught prawn, whereas Ni and Cd were higher in farmed prawn. A higher trace metal contamination was recorded from the cephalothorax part than the abdomen of both sized prawns. However, trace metal concentrations between two sizes of prawns were not statistically significant (p > 0.05). The estimated daily intakes (EDI) values were higher than the recommended and/or tolerable daily intake for Pb and Cr. Moreover, the target hazard quotient (THQ) values were > 1 for Pb, Cd, Cu, and Zn, elucidating non-carcinogenic risks to the consumers. In addition, the target cancer risk (TR) values of Pb and Ni were high and exceeded the acceptable guideline of 10-6, explicating the possibility of carcinogenic risks. Therefore, the study concludes that the consumption of the studied prawn species contaminated with elevated levels of toxic metals is associated with higher degree of potential health risks.


Assuntos
Metais Pesados/análise , Palaemonidae , Poluentes Químicos da Água/análise , Animais , Bangladesh , Bioacumulação , Monitoramento Ambiental , Fazendas , Água Doce , Humanos , Medição de Risco
9.
Artigo em Inglês | MEDLINE | ID: mdl-32182740

RESUMO

The purpose of this prospective cohort study was to investigate the influence of the salivary microbiome on the worsening of the periodontal health status among Japanese young adults. We assessed the data of systemically healthy and non-smoking young (18-22 years) university students (n = 457) from Okayama University at baseline (2013) and follow-up (2016). The worsening group was defined based on an increase in the percentage of bleeding on probing (%BOP) or an increase in probing pocket depth (PPD) from <4 mm to ≥4 mm. Unstimulated saliva samples were randomly collected from 69 students for microbiome analysis at follow-up. The salivary microbiome was assessed through 16S rRNA metagenomic sequencing. The type of community in the salivary microbiome clustered by statistical analysis and diversity was not significantly associated with the worsening of the periodontal health status in cases of increasing %BOP and PPD (p > 0.05). The prevalence of some species was significantly higher in the worsening group than in the non-worsening group (p < 0.05) in both cases. The worsening of the periodontal health status was associated with some species, but not the type of community and diversity in the salivary microbiome among Japanese young adults.


Assuntos
Nível de Saúde , Microbiota , Estudos de Coortes , Humanos , Masculino , Índice Periodontal , Estudos Prospectivos , Saliva , Adulto Jovem
10.
Planta ; 251(3): 66, 2020 Feb 17.
Artigo em Inglês | MEDLINE | ID: mdl-32065312

RESUMO

MAIN CONCLUSION: Glutamine (Gln) is an efficient nitrogen source in promoting aboveground nitrogen and biomass accumulation in ZD958 (an elite maize hybrid with great potential for further genetic improvement) seedlings when conditioning a smaller but adequate root system. Amino acids account for a significant part of nitrogen (N) resources in the soil. However, how amino acid-N affects crop growth remains to be further investigated. Here, glutamine (Gln) application (80% NH4NO3 + 20% Gln; mixed N) enhanced shoot growth of the maize hybrid ZD958. N concentration in the shoot increased, which is associated with favorable increases in SPAD values, GS/GOGAT activities, and accumulation of glutamate, asparagine, total free amino acids and soluble proteins in the shoot under mixed N. On the other hand, root growth was reduced when exposed to Gln as indicated by the significantly lower dry weight, root/shoot ratio, and primary, seminal, crown, and total root lengths, as well as unfavorable physiological alterations. Up-regulation of expression of ZmAMT1.3, ZmNRT2.1, and ZmAAP2 in the root and that of ZmAMT1.1, ZmAMT1.3, and ZmLHT1 in the shoot preconditioned N over-accumulation in the shoot and facilitated shoot growth, presumably via enhancing N translocation to the shoot, when Gln was supplied. Together, Gln is an efficient N source in promoting aboveground N and biomass accumulation in ZD958 seedlings when conditioning a smaller but adequate root system. Notably, ZD958's parental lines Z58 and Chang7-2 displayed a wide range of variations in Gln responses, which may be partially attributed to single nucleotide polymorphisms (SNPs) in cis-elements and coding regions revealed in this study and much larger quantities of unidentified genetic variations between Z58 and Chang7-2. Extensive genetic divergence of these two elite inbred lines implied large potentials for further genetic improvement of ZD958 in relation to organic N use efficiency.


Assuntos
Biomassa , Glutamina/farmacologia , Hibridização Genética , Nitrogênio/metabolismo , Brotos de Planta/metabolismo , Plântula/metabolismo , Zea mays/genética , Zea mays/metabolismo , Alelos , Regulação da Expressão Gênica de Plantas/efeitos dos fármacos , Genes de Plantas , Endogamia , Proteínas de Membrana Transportadoras/genética , Proteínas de Membrana Transportadoras/metabolismo , Metaboloma/efeitos dos fármacos , Metaboloma/genética , Proteínas de Plantas/genética , Proteínas de Plantas/metabolismo , Brotos de Planta/efeitos dos fármacos , Polimorfismo de Nucleotídeo Único/genética , Plântula/efeitos dos fármacos , Transcrição Genética/efeitos dos fármacos , Zea mays/efeitos dos fármacos , Zea mays/crescimento & desenvolvimento
11.
Shock ; 54(1): 44-49, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-31764624

RESUMO

Components of neutrophil extracellular traps (NETs) are released into the circulation by neutrophils and contribute to microcirculatory disturbance in sepsis. Removing NET components (DNA, histones, and proteases) from the circulation could be a new strategy for counteracting NET-dependent tissue damage. We evaluated the effect of hemoperfusion with a polymyxin B (PMX) cartridge, which was originally developed for treating gram-negative infection, on circulating NET components in patients with septic shock, as well as the effect on phorbol myristate acetate (PMA)-stimulated neutrophils obtained from healthy volunteers. Ex vivo closed loop hemoperfusion was performed through PMX filters in a laboratory circuit. Whole blood from healthy volunteers (incubated with or without PMA) or from septic shock patients was perfused through the circuit. For in vivo experiment blood samples were collected before and immediately after hemoperfusion with PMX to measure the plasma levels of cell-free NETs. The level of cell-free NETs was assessed by measuring myeloperoxidase-associated DNA (MPO-DNA), neutrophil elastase-associated DNA (NE-DNA), and cell-free DNA (cf-DNA). Plasma levels of MPO-DNA, NE-DNA, and cf-DNA were significantly increased after 2 h of PMA stimulation. When the circuit was perfused with blood from septic shock patients or PMA-stimulated neutrophils from healthy volunteers, circulating levels of MPO-DNA, NE-DNA, and cf-DNA were significantly reduced after 1 and 2 h of perfusion with a PMX filter compared with perfusion without a PMX filter. In 10 patients with sepsis, direct hemoperfusion through filters with immobilized PMX significantly reduced plasma levels of MPO-DNA and NE-DNA. These ex vivo and in vivo findings demonstrated that hemoperfusion with PMX removes circulating NET components. Selective removal of circulating NET components from the blood could be effective for prevention/treatment of NET-related inappropriate inflammation and thrombogenesis in patients with sepsis.

12.
Artigo em Inglês | MEDLINE | ID: mdl-31546684

RESUMO

The aim of this cross-sectional study was to evaluate the association between the influence of occupational stress and coping style on periodontitis among Japanese workers. The study sample included 738 workers (age range: 19-65 years) at a manufacturing company in Kagawa Prefecture, Japan. To analyze occupational stress and coping style, all participants answered a self-report questionnaire composed of items on their work environment and oral health behavior. Oral examinations were performed by calibrated dentists. Among all workers, 492 (66.7%) workers were diagnosed with periodontitis, and 50 (6.8%) were diagnosed with a high stress-low coping condition. Significant differences (p < 0.05) were observed between the periodontitis and non-periodontitis groups in terms of age, gender, body mass index, smoking status, daily alcohol drinking, monthly overtime work, worker type, and stress-coping style. Logistic regression analysis showed that a high stress-low coping condition was associated with an increased risk of periodontitis (odds ratio: 2.79, 95% confidence interval: 1.05-7.43, p = 0.039). These findings suggest that a high stress-low coping condition is associated with periodontitis among the 19-65 years of age group of Japanese workers.


Assuntos
Adaptação Psicológica , Estresse Ocupacional/epidemiologia , Periodontite/epidemiologia , Adulto , Idoso , Estudos Transversais , Feminino , Humanos , Japão/epidemiologia , Masculino , Pessoa de Meia-Idade , Estresse Ocupacional/complicações , Estresse Ocupacional/psicologia , Periodontite/etiologia , Prevalência , Autorrelato , Adulto Jovem
13.
Qual Life Res ; 28(12): 3213-3224, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31359239

RESUMO

PURPOSE: This prospective cohort study of Japanese university students aimed to identify factors that might affect oral health-related quality of life (OHRQoL) and longitudinal relationships over a period of 3 years. METHODS: Students (n = 487) provided complete data before entering and 3 years later (before university graduation) participated in the present study. Decayed, missing, and filled teeth (DMFT) scores, community periodontal index, ratios (%) of teeth with bleeding on probing, and malocclusion were determined during oral examinations. The questionnaire addressed age, sex, self-rated oral health, oral health behavior, subjective oral symptoms, and OHRQoL determined using the oral health impact profile (OHIP)-14. Associations were analyzed using structural equation modeling (SEM). RESULTS: The OHRQoL significantly worsened according to OHIP-14 total score (p = 0.001). The final model in the symptoms of SEM analysis showed that OHRQoL at follow-up positively correlated with OHRQoL at baseline. Self-rated oral health was directly associated with the OHRQoL at baseline (p < 0.05). CONCLUSIONS: This study determined that OHRQoL at baseline was a direct predictor, and that self-rated oral health were indirect predictors of OHRQoL at follow-up among Japanese university students.


Assuntos
Cárie Dentária/epidemiologia , Má Oclusão/epidemiologia , Saúde Bucal/estatística & dados numéricos , Qualidade de Vida/psicologia , Perda de Dente/epidemiologia , Adolescente , Estudos Transversais , Diagnóstico Bucal , Feminino , Humanos , Japão/epidemiologia , Análise de Classes Latentes , Masculino , Índice Periodontal , Estudos Prospectivos , Estudantes , Inquéritos e Questionários , Universidades , Adulto Jovem
14.
Diabetes Metab Syndr ; 13(3): 1943-1947, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31235119

RESUMO

Fast food and soft drinks consumption leading to excess calorie intake coupled with lack of acceptable physical activity has augmented the prevalence of overweight and obesity among the world population for the past few eras. A cross-sectional study was carried out among 475 youth selected by systematic random sampling attending in 27 established public and private universities and colleges of Bangladesh. The study was aimed to evaluate habitual facts associated with the prevalence of overweight and obesity among Bangladeshi youth. The rates of fast food consumption (once/week) are 50.6%, 43.7%, and 53.3% in overweight, pre-obese and obese-1 respondents accordingly and the rates of soft drinks consumption (4-6 times/week) are 40.5%, 59.2%, and 73.3% respectively for the same subjects. Moreover, approximately 40.8% of the youth went to fast food restaurants at least once per week and 27.2% went regularly (2 times/week). Youth having fast foods 2 times/week, consuming soft drinks 3-4 times/week were more likely to be obese. Besides, obesity epidemic was observed among those who have not the habit of doing physical exercise. This study provides evidence of increasing trend and threat to overweight and obesity for the Bangladeshi youth.


Assuntos
Biomarcadores/análise , Índice de Massa Corporal , Fast Foods/efeitos adversos , Comportamento Alimentar , Estado Nutricional , Obesidade/epidemiologia , Sobrepeso/epidemiologia , Adolescente , Adulto , Bangladesh/epidemiologia , Estudos Transversais , Exercício Físico , Feminino , Seguimentos , Humanos , Masculino , Obesidade/etiologia , Obesidade/metabolismo , Sobrepeso/etiologia , Sobrepeso/metabolismo , Prevalência , Prognóstico , Adulto Jovem
15.
ACS Synth Biol ; 8(5): 1215-1218, 2019 05 17.
Artigo em Inglês | MEDLINE | ID: mdl-31008591

RESUMO

The highly efficient genetic transformation of cells is essential for synthetic biology procedures, especially for the transformation of large gene clusters. In this technical note, we present a novel cell-penetrating peptide (CPP)-mediated large-sized plasmid DNA transformation system for Escherichia coli. A large plasmid (pMSR227, 205 kb) was complexed with cationic peptides containing a CPP motif and was successfully transformed into E. coli cells. The transformants containing the plasmid DNA exhibited expression of a reporter gene encoding a red fluorescent protein. The transformation efficiency was significantly higher than that obtained using the heat-shock method and was similar to that of electroporation. This technique can be used as a platform for the simple and highly efficient transformation of large DNA molecules under mild conditions without causing significant damage to DNA, accelerating synthetic biology investigations for the design of genetically engineered microorganisms for industrial purposes.


Assuntos
Peptídeos Penetradores de Células/genética , Escherichia coli/genética , Plasmídeos/metabolismo , Transformação Genética , Peptídeos Penetradores de Células/metabolismo , Escherichia coli/metabolismo , Genes Reporter , Proteínas Luminescentes/genética , Proteínas Luminescentes/metabolismo , Plasmídeos/genética
16.
IEEE Trans Cybern ; 49(3): 859-869, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-29994360

RESUMO

Nondominated sorting is a key operation used in multiobjective evolutionary algorithms (MOEA). Worst case time complexity of this algorithm is O(MN2) , where N is the number of solutions and M is the number of objectives. For stochastic algorithms like MOEAs, it is important to devise an algorithm which has better average case performance. In this paper, we propose a new algorithm that makes use of faster scalar sorting algorithm to perform nondominated sorting. It finds partial orders of each solution from all objectives and use these orders to skip unnecessary solution comparisons. We also propose a specific order of objectives that reduces objective comparisons. The proposed method introduces a weighted binary search over the fronts when the rank of a solution is determined. It further reduces total computational effort by a large factor when there is large number of fronts. We prove that the worst case complexity can be reduced to Θ(MNCmaxlog2 (F+1)) , where the number of fronts is F and the maximum number of solutions per front is Cmax ; however, in general cases, our worst case complexity is still O(MN2) . Our best case time complexity is O(MNlog N) . We also achieve the best case complexity O(MNlog N+N2) , when all solutions are in a single front. This method is compared with other state-of-the-art algorithms-efficient nondomination level update, deductive sort, corner sort, efficient nondominated sort and divide-and-conquer sort-in four different datasets. Experimental results show that our method, namely, bounded best order sort, is computationally more efficient than all other competing algorithms.

17.
Data Brief ; 18: 144-149, 2018 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-29896503

RESUMO

The data used in this article elucidated crop intensification and farmers' food security status through GO-NGO support in Bangladesh. A total of 200 farmers (100 from non-supported and 100 from GO-NGO supported) were selected for data collection using purposive sampling technique. The collected data showed that GO-NGO support has a significant impact on changes in agricultural enterprises. Majority (63.3%) of the households belong to the low intensity category for non-supported farmers. In case of GO-NGO supported farmers, majority (73.3%) of the households belong to the high intensity category. The food security indices values showed that the food security index for non-supported farm households was 0.97 and for GO-NGO supported farm households, it was 1.07.

18.
Plant Pathol J ; 34(2): 93-103, 2018 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-29628815

RESUMO

Leaf blotch of wheat caused by Bipolaris sorokiniana is a major constraint to wheat production, causing significant yield reduction resulting in severe economic impact. The present study characterizes to determine and compare pathogenic variability exist/not based on components of leaf blotch disease development and level of aggressiveness due to agroclimatic condition of B. sorokiniana in wheat. A total of 169 virulent isolates of B. sorokiniana isolated from spot blotch infected leaf from different wheat growing agroclimate of Bangladesh. Pathogenic variability was investigated on a susceptible wheat variety 'kanchan' now in Bangladesh. A clear evidence of positive relationship among the components was recorded. From hierarchical cluster analysis five groups were originating among the isolates. It resolved that a large amount of pathogenic diversity exists in Bipolaris sorokiniana. Variation in aggressiveness was found among the isolates from different wheat growing areas. Most virulent isolates BS 24 and BS 33 belonging to High Ganges River Flood Plain agro-climatic zones considered by rice-wheat cropping pattern, hot and humid weather, high land and low organic matter content in soil. Positive relationship was found between pathogenic variability and aggressiveness with agro-climatic condition.

19.
3 Biotech ; 8(2): 81, 2018 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-29430345

RESUMO

Lassa virus (LASV) is responsible for an acute viral hemorrhagic fever known as Lassa fever. Sequence analyses of LASV proteome identified the most immunogenic protein that led to predict both T-cell and B-cell epitopes and further target and binding site depiction could allow novel drug findings for drug discovery field against this virus. To induce both humoral and cell-mediated immunity peptide sequence SSNLYKGVY, conserved region 41-49 amino acids were found as the most potential B-cell and T-cell epitopes, respectively. The peptide sequence might intermingle with 17 HLA-I and 16 HLA-II molecules, also cover 49.15-96.82% population coverage within the common people of different countries where Lassa virus is endemic. To ensure the binding affinity to both HLA-I and HLA-II molecules were employed in docking simulation with suggested epitope sequence. Further the predicted 3D structure of the most immunogenic protein was analyzed to reveal out the binding site for the drug design against Lassa Virus. Herein, sequence analyses of proteome identified the most immunogenic protein that led to predict both T-cell and B-cell epitopes and further target and binding site depiction could allow novel drug findings for drug discovery field against this virus.

20.
BMC Complement Altern Med ; 18(1): 35, 2018 Jan 30.
Artigo em Inglês | MEDLINE | ID: mdl-29378554

RESUMO

BACKGROUND: It has been observed that the various part of Baccaurea ramiflora plant is used in rheumatoid arthritis, cellulitis, abscesses, constipation and injuries. This plant also has anticholinergic, hypolipidemic, hypoglycemic, antiviral, antioxidant, diuretic and cytotoxic activities. The present studyaimed to assess the cytotoxic, analgesic, anti-inflammatory, CNS depressant and antidiarrheal activities of methanol extract of Baccaurea ramiflora pulp and seeds in mice model. METHODS: The cytotoxic activity was determined by brine shrimp lethality bioassay; anti-nociceptive activity was determined by acetic acid-induced writhing, formalin- induced licking and biting, and tail immersion methods. The anti-inflammatory, CNS depressant and anti-diarrheal activities were assessed by carrageenan-induced hind paw edema, the open field and hole cross tests, and castor oil-induced diarrheal methods, respectively. The data were analyzed by one way ANOVA (analysis of variance) followed by Dunnett's test. RESULTS: In brine shrimp lethality bioassay, the LC50 values of the methanol extracts of Baccaurea ramiflora pulp and seed were 40 µg/mL and 10 µg/mL, respectively. Our investigation showed that Baccaurea ramiflora pulp and seed extracts (200 mg/kg) inhibited acetic acid induced pain 67.51 and 66.08%, respectively (p < 0.05) that was strongly comparable with that of Ibuprofen (72%) (p < 0.05). The Baccaurea ramiflora pulp and seed extracts (200 mg/kg) significantly (p < 0.05) reduced 58.5 and 53.4 in early and 80.8%, 76.61% in late phase of formalin-induced licking and biting. At 60 and 90 min pulp and seed extracts (200 mg/kg) inhibited nociception of thermal stimulus 50.16 and 62.4%, respectively (p < 0.05) which was comparable with the standard (morphine, 75.9% inhibition). The pulp and seed extracts (200 mg/kg) significantly (p < 0.05) reduced inflammation (42.00 and 55.22%, respectively) in carrageenan-induced hind paw edema and defecations (59.7 and 63.03%, respectively) in castor oil induced diarrhea. Both the extracts showed high sedative activity at 30, 60, 90, and 120 min. CONCLUSION: Our investigation demonstrated significant cytotoxic, analgesic, anti-inflammatory, CNS depressant and antidiarrheal activities of methanol extract of Baccaurea ramiflora pulp and seeds (200 mg/kg).


Assuntos
Analgésicos/farmacologia , Anti-Inflamatórios/farmacologia , Antidiarreicos/farmacologia , Depressores do Sistema Nervoso Central/farmacologia , Extratos Vegetais/farmacologia , Analgésicos/química , Animais , Anti-Inflamatórios/química , Antidiarreicos/química , Artemia/efeitos dos fármacos , Comportamento Animal/efeitos dos fármacos , Depressores do Sistema Nervoso Central/química , Diarreia , Masculino , Camundongos , Manejo da Dor , Extratos Vegetais/química
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