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1.
Eur Rev Med Pharmacol Sci ; 24(22): 11977-11981, 2020 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-33275275

RESUMO

Researchers have found many similarities between the 2003 severe acute respiratory syndrome (SARS) virus and SARS-CoV-19 through existing data that reveal the SARS's cause. Artificial intelligence (AI) learning models can be created to predict drug structures that can be used to treat COVID-19. Despite the effectively demonstrated repurposed drugs, more repurposed drugs should be recognized. Furthermore, technological advancements have been helpful in the battle against COVID-19. Machine intelligence technology can support this procedure by rapidly determining adequate and effective drugs against COVID-19 and by overcoming any barrier between a large number of repurposed drugs, laboratory/clinical testing, and final drug authorization. This paper reviews the proposed vaccines and medicines for SARS-CoV-2 and the current application of AI in drug repurposing for COVID-19 treatment.

2.
Eur Rev Med Pharmacol Sci ; 24(21): 11455-11460, 2020 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-33215473

RESUMO

Recent Coronavirus (COVID-19) is one of the respiratory diseases, and it is known as fast infectious ability. This dissemination can be decelerated by diagnosing and quarantining patients with COVID-19 at early stages, thereby saving numerous lives. Reverse transcription-polymerase chain reaction (RT-PCR) is known as one of the primary diagnostic tools. However, RT-PCR tests are costly and time-consuming; it also requires specific materials, equipment, and instruments. Moreover, most countries are suffering from a lack of testing kits because of limitations on budget and techniques. Thus, this standard method is not suitable to meet the requirements of fast detection and tracking during the COVID-19 pandemic, which motived to employ deep learning (DL)/convolutional neural networks (CNNs) technology with X-ray and CT scans for efficient analysis and diagnostic. This study provides insight about the literature that discussed the deep learning technology and its various techniques that are recently developed to combat the dissemination of COVID-19 disease.


Assuntos
Infecções por Coronavirus/diagnóstico , Infecções por Coronavirus/prevenção & controle , Aprendizado Profundo , Processamento de Imagem Assistida por Computador/métodos , Pulmão/diagnóstico por imagem , Pandemias/prevenção & controle , Pneumonia Viral/diagnóstico , Pneumonia Viral/prevenção & controle , Betacoronavirus/genética , Betacoronavirus/isolamento & purificação , Infecções por Coronavirus/transmissão , Infecções por Coronavirus/virologia , Humanos , Isolamento de Pacientes , Pneumonia Viral/transmissão , Pneumonia Viral/virologia , Reação em Cadeia da Polimerase , Valor Preditivo dos Testes , Quarentena , RNA Viral/isolamento & purificação , Radiografia Torácica , Tomografia Computadorizada por Raios X
3.
Eur Rev Med Pharmacol Sci ; 24(17): 9226-9233, 2020 09.
Artigo em Inglês | MEDLINE | ID: mdl-32965018

RESUMO

Today, the world suffers from the rapid spread of COVID-19, which has claimed thousands of lives. Unfortunately, its treatment is yet to be developed. Nevertheless, this phenomenon can be decelerated by diagnosing and quarantining patients with COVID-19 at early stages, thereby saving numerous lives. In this study, the early diagnosis of this disease through artificial intelligence (AI) technology is explored. AI is a revolutionizing technology that drives new research opportunities in various fields. Although this study does not provide a final solution, it highlights the most promising lines of research on AI technology for the diagnosis of COVID-19. The major contribution of this work is a discussion on the following substantial issues of AI technology for preventing the severe effects of COVID-19: (1) rapid diagnosis and detection, (2) outbreak and prediction of virus spread, and (3) potential treatments. This study profoundly investigates these controversial research topics to achieve a precise, concrete, and concise conclusion. Thus, this study provides significant recommendations on future research directions related to COVID-19.


Assuntos
Inteligência Artificial , Infecções por Coronavirus/diagnóstico , Pneumonia Viral/diagnóstico , Betacoronavirus/isolamento & purificação , Infecções por Coronavirus/terapia , Infecções por Coronavirus/virologia , Surtos de Doenças , Humanos , Imunidade Humoral , Pandemias , Pneumonia Viral/terapia , Pneumonia Viral/virologia
4.
J Med Case Rep ; 10(1): 335, 2016 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-27906109

RESUMO

BACKGROUND: Primary melanoma of the small bowel is extremely rare. Only a limited number of cases have been described in the literature. Mostly, the small intestine is affected by metastatic tumors of other primary lesions, especially cutaneous. CASE PRESENTATION: We report the case of a 75-year-old North African woman with a small bowel melanoma. The diagnosis was made by histological examination and immunohistochemical profile matching after a segmental small bowel resection. Postoperative investigations looking for cutaneous, gastrointestinal or ocular primary lesions found no abnormalities. CONCLUSIONS: The diagnosis of primary small bowel melanoma can be retained although it remains difficult to exclude the possibility of metastatic melanoma.


Assuntos
Hemorragia Gastrointestinal/patologia , Neoplasias Intestinais/patologia , Intestino Delgado/patologia , Melanoma/patologia , Idoso , Anastomose Cirúrgica , Diagnóstico Diferencial , Feminino , Hemorragia Gastrointestinal/diagnóstico por imagem , Humanos , Imuno-Histoquímica , Neoplasias Intestinais/diagnóstico por imagem , Neoplasias Intestinais/cirurgia , Intestino Delgado/diagnóstico por imagem , Melanoma/diagnóstico por imagem , Melanoma/cirurgia , Dor Pélvica , Tomografia Computadorizada por Raios X , Resultado do Tratamento
6.
Clin Res Hepatol Gastroenterol ; 35(8-9): 590-3, 2011 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-21349787

RESUMO

Gastrointestinal stromal tumors (GISTs) represent the majority of primary non-epithelial neoplasms of the digestive tract, most frequently expressing the KIT protein detected by immunohistochemical staining for the CD117 antigen. Extragastrointestinal stromal tumors (EGISTs), neoplasms with immunohistological features overlapping those of GISTs, are found in the abdomen outside of the gastrointestinal tract with no connection to the gastric or intestinal wall. The present report presents the clinical, macroscopic and immunohistological features of an EGIST arising in the greater omentum of a 63-year-old woman, and discusses the clinical behavior and prognostic factors of such lesions in comparison to their gastrointestinal counterparts.


Assuntos
Tumores do Estroma Gastrointestinal , Omento , Neoplasias Peritoneais , Feminino , Tumores do Estroma Gastrointestinal/diagnóstico , Tumores do Estroma Gastrointestinal/cirurgia , Humanos , Pessoa de Meia-Idade , Neoplasias Peritoneais/diagnóstico , Neoplasias Peritoneais/cirurgia
10.
Rev Pneumol Clin ; 64(5): 221-4, 2008 Oct.
Artigo em Francês | MEDLINE | ID: mdl-18995149

RESUMO

INTRODUCTION: Pulmonary alveolar microlithiasis is a rare disease characterised by the formation and deposition of calcium phosphate microliths in the lung. It is an autosomal recessive disorder, for which mutation in the SLC34A2 gene was recently found to be responsible for the disease. OBSERVATIONS: We report on four cases of pulmonary alveolar microlithiasis. Three patients were asymptomatic. The diagnosis was made after histological confirmation in three patients. The outcome was marked by the death of one patient. CONCLUSION: Pulmonary alveolar microlithiasis is a rare disease. Diagnosis is made with high-resolution computed tomography, which exhibits the calcic character and distribution of the lesions, thus avoiding the need to perform lung biopsy. We suggest that a literature review be performed.


Assuntos
Litíase , Pneumopatias , Alvéolos Pulmonares , Adolescente , Adulto , Biópsia , Broncoscopia , Feminino , Humanos , Litíase/diagnóstico , Litíase/diagnóstico por imagem , Litíase/genética , Litíase/patologia , Pulmão/patologia , Pneumopatias/diagnóstico , Pneumopatias/diagnóstico por imagem , Pneumopatias/genética , Pneumopatias/patologia , Masculino , Alvéolos Pulmonares/diagnóstico por imagem , Alvéolos Pulmonares/patologia , Radiografia Torácica , Proteínas Cotransportadoras de Sódio-Fosfato Tipo IIb , Tomografia Computadorizada por Raios X
11.
Chir Main ; 25(3-4): 166-8, 2006 Sep.
Artigo em Francês | MEDLINE | ID: mdl-17175806

RESUMO

Hibernomas are rare benign tumours originating from the brown fat found in the foetus and animals that hibernate. In most cases they present as a slowly growing painful mass situated in those regions where this type of fat persists in the adult. We report a case of hibernoma of the forearm, which is an unusual localization, and we review the diagnostic and therapeutic aspects of this of tumour whose main differential diagnosis is liposarcoma.


Assuntos
Antebraço , Lipoma , Neoplasias Musculares , Diagnóstico Diferencial , Feminino , Antebraço/patologia , Humanos , Lipoma/diagnóstico , Lipoma/patologia , Lipoma/cirurgia , Lipossarcoma/diagnóstico , Imagem por Ressonância Magnética , Pessoa de Meia-Idade , Neoplasias Musculares/diagnóstico , Neoplasias Musculares/patologia , Neoplasias Musculares/cirurgia
12.
Ann Endocrinol (Paris) ; 67(1): 64-8, 2006 Mar.
Artigo em Francês | MEDLINE | ID: mdl-16596061

RESUMO

Thyroid sarcomatoid carcinoma is a rare and aggressive neoplasm composed of a follicular carcinoma which is contiguous or admixed with a pleomorphic spindle cell component. We report the case of a thyroid tumor reputed to have a poor outcome, in a 62-year-old woman. The radical thyroidectomy specimen was totally invaded. Results of immunoperoxidase staining for thyroglobulin and epithelial markers were positive in the areas of follicular carcinoma and negative in the sarcomatous component. The patient died a few days later due to septic shock. The epithelial and mesenchymal components of thyroid carcinosarcoma were both part of the neoplastic parenchyma and evolved from a single common stem cell, in agreement with the hypothesis that the tumors are of monoclonal origin. The definition of this tumor as its histogenesis and prognostic are discussed.


Assuntos
Carcinoma/patologia , Sarcoma/patologia , Neoplasias da Glândula Tireoide/patologia , Carcinoma/cirurgia , Feminino , Humanos , Pessoa de Meia-Idade , Prognóstico , Sarcoma/cirurgia , Neoplasias da Glândula Tireoide/cirurgia , Tireoidectomia , Resultado do Tratamento
13.
Rev Mal Respir ; 23(5 Pt 1): 453-7, 2006 Nov.
Artigo em Francês | MEDLINE | ID: mdl-17314745

RESUMO

INTRODUCTION: Giant-cell tumors of bone are rare primary neoplasms commonly encountered in young adults. Women are slightly more affected than men. CASE REPORT: We report the case a 27 year old woman presenting with a twelve months history of painful and progressively growing thoracic mass in the right anterior chest wall. Physical examination found out a fixed thoracic mass in the right retro-mammary area measuring 8 x 6 centimeters. The overlying skin was normal. Chest roentgenogram demonstrated a large ill defined mass continuing the anterior arc of the fourth right rib. Computed tomography evidenced a well defined pathologic process originating from the fourth right rib without expansion of the surrounding soft tissue. Pulmonary functional tests were normal and other complementary investigations evidenced no abnormalities. Our patient first had a fine needle cytological biopsy that brought strong suspicion of Giant-cell tumor of the rib. She then underwent an "en bloc" resection of the tumor whose histopathologic analysis allowed a definitive diagnosis. The post-surgical follow up during 12 months showed no signs of tumor recurrence. CONCLUSION: Through this observation the authors emphasize not only the rarity of the giant-cell tumors of bone but also its unusual costal localization (few cases reported till date). They focus on the importance of precocious screening and treatment and underline the value of the follow up in order to detect timely any sign of local recurrence or sarcomatous transformation. Finally, they report a current review of the literature.


Assuntos
Neoplasias Ósseas/cirurgia , Tumor de Células Gigantes do Osso/cirurgia , Costelas , Adulto , Neoplasias Ósseas/diagnóstico por imagem , Feminino , Tumor de Células Gigantes do Osso/diagnóstico por imagem , Humanos , Tomografia Computadorizada por Raios X , Resultado do Tratamento
14.
Presse Med ; 34(20 Pt 1): 1515-7, 2005 Nov 19.
Artigo em Francês | MEDLINE | ID: mdl-16301963

RESUMO

INTRODUCTION: Primary sarcomas of the great vessels, that is, the aorta, pulmonary artery, and inferior vena cava, are rare. They can be classified according to the location of the sarcoma in the vessel wall and by their gross appearance. Most often they are leiomyosarcomas or fibrosarcomas. CASE: We report here a case of an intimal sarcoma of the inferior vena cava. Histological and immunohistochemical findings confirmed the diagnosis for this 17-year-old girl and distinguished it from leiomyosarcoma and angiosarcoma, both of which have better prognoses. DISCUSSION: Intimal sarcoma of the inferior vena cava is rare and difficult to diagnose before surgery or biopsy. Histologically, it is a poorly differentiated tumor with the worst prognosis among the primary vascular sarcomas. Pathologic findings and immunohistochemical staining are useful for a positive diagnosis.


Assuntos
Sarcoma/diagnóstico , Túnica Íntima/patologia , Neoplasias Vasculares/diagnóstico , Veia Cava Inferior/patologia , Adolescente , Autoanticorpos/análise , Implante de Prótese Vascular , Evolução Fatal , Feminino , Humanos , Sarcoma/cirurgia , Túnica Íntima/cirurgia , Neoplasias Vasculares/cirurgia , Veia Cava Inferior/cirurgia , Vimentina/imunologia
15.
Rev Pneumol Clin ; 60(3): 171-4, 2004 Jun.
Artigo em Francês | MEDLINE | ID: mdl-15292827

RESUMO

Pleural fibroma, or fibrous tumor of the pleura, is an uncommon entity which is characterized by slow proliferation of undifferentiated, intermediary or mature fibroblasts associated with collagen fibers forming a tumor stroma. We report a case in a 49-Year-old man who developed exercise-induced dyspnea and right chest pain. The thoracic CT scan revealed the presence of a mass in the right lung base composed of heterogeneous encapsulated tIssue. Tumor resection was performed leading to the histological diagnosis of pleural fibroma. Immunohistochemistry tests revealed positive vimetin and CD34, and negative cytokeratin uptake. These immunohistochemistry data contributed to the differential diagnosis with malignant pleural mesothelium. Pleural fibroma is a benign tumor in 80% of the cases. Prognosis is excellent. Local recurrence is exceptional and generally occurs after incomplete resection. Radial surgical treatment determines the prognosis and is required to prevent local recurrence. Other criteria of malignancy are not correlated with the clinical course of this type of tumor.


Assuntos
Fibroma/patologia , Neoplasias Pleurais/patologia , Dor no Peito/etiologia , Fibroma/cirurgia , Humanos , Imuno-Histoquímica , Masculino , Pessoa de Meia-Idade , Neoplasias Pleurais/cirurgia , Prognóstico
16.
Rev Med Liege ; 58(12): 757-60, 2003 Dec.
Artigo em Francês | MEDLINE | ID: mdl-14978850

RESUMO

Tuberculosis of the gallbladder is rare, even in our country known for being an endemic area. The positive diagnosis depends on suspicion of tuberculosis, peroperative findings and histological examination. From a review of the literature, the physiopathology of this infection is discussed, emphasizing the role of lithiasis in the development of tuberculous lesions. The authors report a case of gallbladder tuberculosis in a female patient who presented with a clinical picture of chronic cholelithiasis. The diagnosis of gallbladder tuberculosis was reached only after surgery and proven by histopathology. In our case, the presence of stones associated with non specific inflammatory alterations and possibly low resistance against tubercle bacillus, is believed to have been of importance for the development of the tuberculous infection.


Assuntos
Colelitíase/complicações , Doenças da Vesícula Biliar/diagnóstico , Tuberculose/diagnóstico , Colelitíase/cirurgia , Doença Crônica , Feminino , Doenças da Vesícula Biliar/complicações , Humanos , Pessoa de Meia-Idade , Tuberculose/complicações
17.
Prog Urol ; 9(3): 534-6, 1999 Jun.
Artigo em Francês | MEDLINE | ID: mdl-10434331

RESUMO

The development of cancer on the ileal graft after augmentation ileocystoplasty benign bladder disease is a little known complication. The authors report a case of squamous cell carcinoma in the ileal bladder occurring 31 years after augmentation ileocystoplasty for tuberculous bladder, in a 60-year-old patient. The ileal bladder was resected and a new augmentation ileocystoplasty was performed. The postoperative course was uneventful. Histological examination of the operative specimen showed infiltration of all of the intestinal wall. The patient died one year after, in a context of peritoneal carcinomatosis.


Assuntos
Carcinoma de Células Escamosas/diagnóstico por imagem , Tuberculose/complicações , Neoplasias da Bexiga Urinária/diagnóstico por imagem , Bexiga Urinária/cirurgia , Carcinoma de Células Escamosas/patologia , Carcinoma de Células Escamosas/cirurgia , Humanos , Masculino , Pessoa de Meia-Idade , Invasividade Neoplásica , Tomografia Computadorizada por Raios X , Neoplasias da Bexiga Urinária/patologia , Neoplasias da Bexiga Urinária/cirurgia , Urografia
18.
Prog Urol ; 9(2): 310-2, 1999 Apr.
Artigo em Francês | MEDLINE | ID: mdl-10370957

RESUMO

Primary sarcomas of the kidney are exceptional, representing 1 to 3% of all renal tumours in adults. They have a poor prognosis. The authors report a case of primary leiomyosarcoma of the kidney in a 44-year old patient, presenting in the form of low back pain and haematuria. Treatment consisted of radical nephrectomy. Two months later, the patient presented with hepatic metastases. The patient is currently receiving chemotherapy.


Assuntos
Neoplasias Renais/diagnóstico , Leiomiossarcoma/diagnóstico , Adulto , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Doxorrubicina/administração & dosagem , Feminino , Humanos , Ifosfamida/administração & dosagem , Neoplasias Renais/diagnóstico por imagem , Neoplasias Renais/patologia , Neoplasias Renais/cirurgia , Leiomiossarcoma/diagnóstico por imagem , Leiomiossarcoma/patologia , Leiomiossarcoma/secundário , Leiomiossarcoma/cirurgia , Neoplasias Hepáticas/tratamento farmacológico , Neoplasias Hepáticas/secundário , Tomografia Computadorizada por Raios X
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