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1.
J Clin Rheumatol ; 25(3): e16-e26, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-29782427

RESUMO

OBJECTIVES: The aims of this study were to describe clinical and laboratory manifestations of patients with levamisole-adulterated cocaine-induced vasculitis/vasculopathy and to propose a skin classification according to the distribution and severity of lesions. METHODS: We report the characteristics of 30 patients admitted with levamisole-adulterated cocaine-induced vasculitis/vasculopathy in 4 high-complexity institutions in Colombia, from December 2010 to May 2017. We compare our findings with the main published series. RESULTS: Median age was 31 years (interquartile range, 27-38 years) with a male-to-female ratio of 5:1. Eighty-three percent of the patients had retiform purpura affecting the limbs, buttocks, face, or abdomen; 73% had ear necrosis, 50% cutaneous ulcers, 17% genital necrosis, 13% oral ulcers, and 10% digital necrosis. Cutaneous involvement was classified according to the frequency of the compromised corporal area, and purpuric lesions were stratified in 4 grades of severity. Anti-neutrophil cytoplasmic autoantibodies were positive in 85% of the cases, lupus anticoagulant in 73%, and antinuclear autoantibodies in 57%; rheumatoid factor was negative in all cases. We found nephritis in 17 cases (57%). Prednisolone was used in most of the patients (70%), with other immunosuppressive agents being used in a lower percentage. Improvement was observed in 93% of the patients, but symptoms recurred in 40%, attributed to relapses in consumption. End-stage chronic renal disease developed in 10% of the cases, and 1 patient died. CONCLUSIONS: Because of rising cocaine consumption and levamisole adulteration frequency, levamisole-adulterated cocaine-induced vasculitis/vasculopathy is becoming more common. Detailed characterization of skin involvement coupled with multiple antibody positivity is essential for a diagnosis. Renal involvement is frequent, clinically and histologically heterogeneous, and potentially serious.


Assuntos
Transtornos Relacionados ao Uso de Cocaína/complicações , Cocaína , Glomerulonefrite , Levamisol , Púrpura , Vasculite , Adjuvantes Farmacêuticos/efeitos adversos , Adjuvantes Farmacêuticos/farmacologia , Adulto , Autoanticorpos/sangue , Cocaína/farmacologia , Colômbia , Inibidores da Captação de Dopamina/farmacologia , Contaminação de Medicamentos , Feminino , Glomerulonefrite/induzido quimicamente , Glomerulonefrite/diagnóstico , Glomerulonefrite/imunologia , Glomerulonefrite/terapia , Humanos , Levamisol/efeitos adversos , Levamisol/farmacologia , Masculino , Necrose , Administração dos Cuidados ao Paciente/métodos , Púrpura/induzido quimicamente , Púrpura/diagnóstico , Púrpura/imunologia , Púrpura/terapia , Pele/patologia , Resultado do Tratamento , Vasculite/induzido quimicamente , Vasculite/diagnóstico , Vasculite/imunologia , Vasculite/terapia
2.
J Clin Rheumatol ; 25(2): 101-107, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30028809

RESUMO

BACKGROUND/OBJECTIVE: Although mortality rates related with chikungunya (CHIK) outbreaks in Latin America's (LA's) dengue-endemic rural and new urban regions are low, dealing with symptoms and sequelae can both produce a significant burden of disease and diminish quality of life-from many months to years-after the acute phase of the infection, with a significant impact on public and individual health.The aim of this work was to establish Pan-American League of Associations for Rheumatology-Central American, Caribbean and Andean Rheumatology Association (ACCAR) consensus-conference endorsements and recommendations on the diagnosis and treatment of CHIK-related inflammatory arthropathies transmitted by Aedes aegypti and Aedes albopictus in LA. METHODS: Based on the Consensus Development Conference format, a panel of ACCAR rheumatologist voting members (n = 10) took part in this Pan-American League of Associations for Rheumatology initiative. Experts voted from a previous content analysis of the medical literature on CHIK, 4 subsequent topic conferences, and a workshop. Consensus represents the majority agreement (≥80%) achieved for each recommendation. RESULTS: The experts' panel reached 4 overarching principles: (1) CHIK virus (CHIKV) is a re-emergent virus transmitted by 2 species of mosquitoes: A. aegypti and A. albopictus; (2) CHIKV caused massive outbreaks in LA; (3) chronic CHIKV infection produces an inflammatory joint disease that, in some cases, can last for several months to years, and (4) currently, there are no vaccines or antivirals licensed for CHIKV infections. RECOMMENDATIONS: Pan-American League of Associations for Rheumatology-ACCAR achieved 13 endorsements and recommendations on CHIK categorized in 3 groups: (1) epidemiology and clinical manifestations, (2) diagnosis, and (3) treatment, representing the consensus agreement from the panel's members.


Assuntos
Artrite Infecciosa/diagnóstico , Artrite Infecciosa/terapia , Febre de Chikungunya/complicações , Política de Saúde , Reumatologia , Artrite Infecciosa/virologia , Consenso , Humanos , América Latina , Sociedades Médicas
3.
Salud UNINORTE ; 34(2): 409-419, mayo-ago. 2018. tab
Artigo em Inglês | LILACS-Express | ID: biblio-1004593

RESUMO

Abstract Objective: To explore the demographic, health and functional factors associated with depression in the elderly in three cities from Colombia: Medellin, Barranquilla and Pasto. Materials and methods: An analytical cross-sectional study. The study population corresponded to a probabilistic sample of 1514 adult whose age is 60 years or over. A sample was selected by a probabilistic sampling, in two-stage, and conglomerate, according to the geographical and administrative distribution of each city. Results: The results support that the city of Pasto presents the highest number of elderly people with depression; conditions such as low educational level (PR = 4.11), hyperthyroidism / hypothyroidism (PR = 3.43), and dependence on activities of daily living such as using the telephone (PR = 3.80) increase the prevalence of the disease. Conclusion: Depression is present in an important part of the population of older adults and is associated with conditions not only of health but also demographic and functional capacity. It is necessary to address these components from the public health that promotes the prevention of this condition if you want to contribute to the goals of active, satisfactory and healthy aging in Colombia and a better quality of life for this population.


Resumen Objetivo: Explorar los factores demográficos, de salud y de funcionalidad asociados con la depresión en los adultos mayores en tres ciudades de Colombia: Medellín, Barranquilla y Pasto. Material y métodos: Estudio analítico transversal. La población del estudio correspondió a una muestra probabilística de 1514 adultos de 60 años y más. La muestra fue seleccionada mediante un muestreo probabilístico, por conglomerado, bietápico, según la distribución geográfica y administrativa de cada ciudad. Resultados: Los resultados muestran que la ciudad de Pasto presenta el mayor número de adultos mayores con depresión; condiciones como el bajo nivel educativo (RP=4,11), el hipertiroidismo/hipotiroidismo (RP=3,43), y la dependencia en actividades básicas de la vida diaria como usar el teléfono (RP=3,80) incrementan la prevalencia de la enfermedad. Conclusión: La depresión está presente en una parte importante de la población de adultos mayores y está asociada a condiciones no solo de salud sino también demográficas y de la capacidad funcional. Se hace necesario el abordaje de estos componentes desde la salud pública que promueva la prevención de esta condición si se quiere contribuir con las metas de envejecimiento activo, satisfactorio y saludable en Colombia y una mejor calidad de vida para esta población.

4.
Aquichan ; 18(2): 210-221, abr.-jun. 2018. tab
Artigo em Espanhol | LILACS-Express | ID: biblio-949997

RESUMO

RESUMEN Objetivo: identificar los factores asociados a la vulnerabilidad cognitiva de los adultos mayores en tres ciudades de Colombia en el año 2016. Materiales y método: se condujo un estudio cuantitativo, transversal analítico, con fuente de información primaria, encuestando a 1514 adultos mayores residentes en la zona urbana de Barranquilla, Medellín y Pasto, empleando muestreo probabilístico bietápico. La condición cognitiva se evaluó con el Mini Examen Cognoscitivo modificado. Se realizaron análisis univariados, bivariados y multivariados, cálculos estadísticos y epidemiológicos, intervalos de confianza y pruebas estadísticas menores del 5%. Resultados: el riesgo de deterioro cognitivo se presentó en un 5,1% en Medellín, un 2,7% en Pasto y un 1,7% en Barranquilla, predominantemente en hombres, con edades entre los 75 y 89 años, sin pareja y con bajos niveles de escolaridad. El 100% de quienes tenían deterioro cognitivo refieren no realizar actividad física, el 13% reportaron depresión y el 7,7% soporte social escaso. Conclusiones: los factores asociados a la vulnerabilidad cognitiva de los adultos mayores incluyen características demográficas, sociales y de estilos de vida. Es importante considerar estos resultados en las políticas de salud para la población de adultos mayores con el fin de reorientar la atención en la prevención de la vulnerabilidad cognitiva.


ABSTRACT Objective: Identify the factors associated with the cognitive vulnerability of older adults in three Colombian cities during 2016. Materials and methods: A quantitative, cross-sectional, analytical study was conducted with a primary source of information by surveying 1514 older adults living in the urban areas of Barranquilla, Medellín and Pasto. Two-stage probabilistic sampling was used. The cognitive condition of the adults in the sample was evaluated with the modified Mini Cognitive Exam. Univariate, bivariate and multivariate analyzes, statistical and epidemiological calculations, confidence intervals and statistical tests of less than 5% were performed. Results: The risk of cognitive deterioration was found in 5.1% of the sample in Medellín, 2.7% in Pasto and 1.7% in Barranquilla, predominantly among men between 75 and 89 years of age who are without a partner and have low levels of schooling. One hundred percent (100%) of those with cognitive impairment reported having no physical activity, 13% reported depression, and 7.7% indicated social support was scarce. Conclusions: The factors associated with cognitive vulnerability among older adults include demographic, social and lifestyle characteristics. It is important to consider these results when drafting health policies for the elderly population to redirect attention to the prevention of cognitive vulnerability.


RESUMO Objetivo: identificar os fatores associados à vulnerabilidade cognitiva dos idosos em três cidades da Colômbia em 2016. Materiais e método: estudo quantitativo, transversal analítico, com fonte de informação primária, que entrevistou 1514 idosos residentes na zona urbana de Barranquilla, Medellín e Pasto, empregando amostra probabilística bietápica. A condição cognitiva foi avaliada com o Miniexame Cognoscitivo Modificado. Foram realizadas análises univariadas, bivariadas e multivariadas, cálculos estatísticos e epidemiológicos, intervalos de confiabilidade e testes estatísticos menores de 5 %. Resultados: o risco de deterioração cognitiva foi apresentado em 5,1 % em Medellín; 2,7 % em Pasto e 1,7 % em Barranquilla, predominantemente em homens, com faixa etária entre 75 e 89 anos, sem companheiro(a) e com baixo nível de escolaridade. 100 % dos que apresentaram deterioração cognitiva referem não realizar atividade física; 13 % relataram depressão e 7,7 %, apoio social escasso. Conclusão: os fatores associados à vulnerabilidade cognitiva dos idosos incluem características demográficas, sociais e de estilos de vida. É importante considerar os resultados nas políticas de saúde para a população de idosos a fim de reorientar a atenção na prevenção da vulnerabilidade cognitiva.

5.
Reumatol Clin ; 2018 May 19.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-29789229

RESUMO

We report the case of a 47-year-old man with a 9-year history of psoriatic arthritis (PsA) in whom we detected renal involvement, hypocomplementemia, peripheral neuropathy, acral necrotic lesions and positive cryoglobulins. The results of the diagnosis led us to conclude that the clinical picture corresponded to cryoglobulinemic vasculitis concomitant with PsA. In addition, we present a review of the literature on the presence of these two diseases in a single patient.

6.
Semin Arthritis Rheum ; 45(6): 675-83, 2016 06.
Artigo em Inglês | MEDLINE | ID: mdl-26698222

RESUMO

OBJECTIVE: To examine hematological manifestations' correlates and their impact on damage accrual and mortality in SLE patients from the multiethnic, Latin American, GLADEL cohort. METHODS: In patients with recent SLE diagnosis (≤2 years), the association between follow-up hematological manifestations (per ACR criteria) and socio-demographic and clinical variables was examined by univariable and multivariable logistic regressions; their impact on damage accrual and mortality was examined by Poisson and Cox proportional-hazards regression analyses, respectively. RESULTS: Of 1437 patients, 948 (66.0%) developed ≥1 hematological manifestation [5.5% hemolytic anemia (AHA), 16.3% thrombocytopenia, and 56.4% lymphopenia] over 4.3 (3.3) follow-up years. Younger age, Mestizo ethnicity, hematologic disorder (at/or before SLE diagnosis), and first damage recorded were associated with hematological manifestations while antimalarials were negatively associated. AHA (at/or before SLE diagnosis), anti-Sm, and anti-RNP antibodies were associated with subsequent AHA occurrence while musculoskeletal involvement was negatively associated. Thrombocytopenia (at/or before SLE diagnosis), AHA, anti-phospholipid antibodies (aPLs), anti-SSA/Ro, anti-SSB/La antibodies, and first damage recorded were associated with later thrombocytopenia occurrence. Lymphopenia (at/or before SLE diagnosis), younger age at diagnosis, Mestizo ethnicity, having medical insurance, and first damage recorded were associated with subsequent lymphopenia occurrence while antimalarials and azathioprine treatment were negatively associated. AHA was associated with damage accrual and mortality after adjusting for variables known to affect these outcomes. CONCLUSIONS: Mestizo ethnicity and early hematological manifestations are risk factors for their subsequent occurrence while antimalarials have a protective effect. The associations between AHA and aPLs and thrombocytopenia were corroborated. AHA contributes independently to damage accrual and diminished survival.


Assuntos
Anemia Hemolítica/sangue , Lúpus Eritematoso Sistêmico/sangue , Linfopenia/sangue , Trombocitopenia/sangue , Adolescente , Adulto , Grupo com Ancestrais do Continente Africano , Fatores Etários , Anemia Hemolítica/etnologia , Anemia Hemolítica/etiologia , Anticorpos Antinucleares/imunologia , Anticorpos Antifosfolipídeos/imunologia , Antimaláricos/uso terapêutico , Autoanticorpos/imunologia , Azatioprina/uso terapêutico , Grupos Étnicos , Grupo com Ancestrais do Continente Europeu , Feminino , Humanos , Imunossupressores/uso terapêutico , Índios Sul-Americanos , Seguro Saúde , América Latina , Modelos Logísticos , Estudos Longitudinais , Lúpus Eritematoso Sistêmico/complicações , Lúpus Eritematoso Sistêmico/tratamento farmacológico , Lúpus Eritematoso Sistêmico/imunologia , Linfopenia/etnologia , Linfopenia/etiologia , Masculino , Análise Multivariada , Modelos de Riscos Proporcionais , Ribonucleoproteínas/imunologia , Trombocitopenia/etnologia , Trombocitopenia/etiologia , Adulto Jovem
7.
Rev. Fac. Med. (Bogotá) ; 62(3): 1-24, July-Sept. 2014. ilus
Artigo em Espanhol | LILACS-Express | ID: lil-726933

RESUMO

El fenómeno de Raynaud es una respuesta vascular exagerada al frío o al estrés que se manifiesta por cambios de coloración de la piel en diversas localizaciones; característicamente, presenta tres fases distintas que comprenden palidez, cianosis y rubor. Dependiendo de la ausencia o la presencia de enfermedad de base, el fenómeno se denomina como primario o secundario, siendo este último subtipo una manifestación importante de enfermedades graves, principalmente autoinmunes. El fenómeno de Raynaud primario tiene buen pronóstico y la posibilidad de manejo por médico primario; por el contrario, el secundario implica la necesidad de evaluación y manejo especializado. Es de importancia para el médico general conocer su clasificación, las bases del manejo para control de los signos y síntomas, además de identificar cuándo un paciente requiere valoración y manejo especializado de acuerdo con otras enfermedades de base que puedan coexistir.


Raynaud's phenomenon is an exaggerated vascular response to cold or stress manifested by skin colour changes at several locations, having three characteristic phases: pallor (white), cyanosis (blue) and rubor (red). When the cause is not known this phenomenon is termed primary Raynaud's phenomenon and secondary Raynaud's phenomenon when underlying disease is involved, autoimmune disease being the most frequent cause of the secondary form. Primary Raynaud's phenomenon has a good prognosis and can be treated medically without the need for specialist assessment, unlike secondary Raynaud's phenomenon which needs specialist assessment and treatment. A general practitioner needs to know the classification, the basis for treatment for signs and symptoms control and know when a patient requires specialist evaluation for treatment according to other diseases which may be present or coexist.

8.
Rev. colomb. reumatol ; 21(2): 99-103, abr. 2014. ilus, tab
Artigo em Espanhol | LILACS | ID: lil-717045

RESUMO

La fibrosis retroperitoneal es una entidad clínica, de presentación poco frecuente,caracterizada por un trastorno fibroso e inflamatorio crónico, que rodea estructurasabdominales, principalmente los aspectos peri vasculares de las mismas, y que esexplicada por diferentes etiologías, siendo las más importantes la fibrosis retroperitonealidiopática y la fibrosis secundaria a trastornos relacionados con la subclase de IgG4. Por suparte, la hiperostosis cortical generalizada pertenece a un grupo de enfermedades raras depatologías metabólicas óseas osteocondensantes. En este caso, se presenta una pacientede 45 años de edad con fibrosis retroperitoneal, de etiología no establecida, asociada ahiperostosis cortical generalizada. La asociación de estas dos patologías, no reportadaanteriormente en la literatura, parece ser una relación espuria, sin embargo, existenalgunos mecanismos patogénicos entrelazados.


Retroperitoneal fibrosis is a rare clinical condition, characterized by a fibro-inflammatory disorder that surrounds abdominal structures, principally at perivascular level, and that is explained by different etiologies like idiopathic fibrosis and IgG4 related disorders. Generalized cortical hyperostosis belongs to a group of rare metabolic bone condensation diseases.The case is presented of a 45 year old female patient with a retroperitoneal fibrosis of unknown origin associated with generalized cortical hyperostosis. The association of these two conditions has not previously reported in the literature. This appears to be a spurious relationship, although some pathogenic mechanisms are intertwined.


Assuntos
Humanos , Osteocondrodisplasias , Fibrose Retroperitoneal
9.
Rev. colomb. reumatol ; 20(3): 155-170, jul.-set. 2013. ilus, tab
Artigo em Espanhol | LILACS | ID: lil-696635

RESUMO

Resumen La esclerosis sistémica (escleroderma) es una enfermedad autoinmune del tejido conectivo cuya causa no ha sido definida, con gran morbilidad y mortalidad, dadas sus múltiples complicaciones tanto cutáneas como sistémicas. A pesar de ser reconocida desde hace siglos, aún no se cuenta con intervenciones óptimas para controlar definitivamente su progresión y evitar la aparición de lesiones en órganos diferentes a la piel. Teniendo como características clínicas sobresalientes el fenómeno de Raynaud y los cambios fibróticos cutáneos, el objetivo de esta investigación histórica es presentar las descripciones clínicas y patológicas históricas, mostrando la evolución en el enfoque y manejo de estos pacientes, desde siglos atrás hasta la actualidad. Objetivos: Hacer una aproximación a las primeras descripciones históricas de los aspectos clínicos relacionados con las manifestaciones cutáneas y de anexos de la esclerosis sistémica progresiva, resaltando a los individuos que por siglos han aportado al entendimiento de la enfermedad. Materiales y métodos: Investigación de corte histórico, con revisión de la literatura desde el siglo xvii hasta el año 2013, en especial, de textos que impactan en el entendimiento de la evolución clínica de los aspectos cutáneos de la enfermedad. Se realiza una búsqueda sistémica de la información disponible en medios virtuales y físicos, en bibliotecas de América y Europa, teniendo acceso a textos originales en diferentes idiomas y realizando la traducción de los mismos, con miras a enmarcar los resultados de las descripciones en una línea de tiempo.


Abstract Systemic sclerosis (scleroderma) is a connective tissue autoimmune disease with an unknown etiology, with a wide range of skin and cutaneous complications wich explains the morbility and mortality of this entity. Recognized since centuries, there are not optimal interventions yet to control its progression and avoid lesions in different organs besides skin. The most characteristic clinical pictures are Raynaud phenomenon and cutaneous fibrosis, this is why the first objective of this historical investigation is to present the clinical and pathological historical descriptions of these disease, showing the evolution in the approach and management of patients with this malady in an historical view. Objectives: To make an approximation to the first historical descriptions of the clinical aspects related with de cutaneous commitment in patients with progressive systemic sclerosis, highlighting some persons who have made seminal contributions to the understanding of this disease. Material and methods: Historical investigation with an extensive literature review from century xvii to xxi, we include electronic and physical information from different libraries from America and Europe. We describe all the information in a time line.


Assuntos
Humanos , Calcinose , Doença de Raynaud , Escleroderma Sistêmico
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