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PLoS One ; 16(4): e0250108, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33852644


We investigated changes in gene expression of cervical collagens, matrix metalloproteinases (MMPs), and tissue inhibitors of metalloproteinases (TIMPs) during pre-gestational uterine cervical excision and/or inflammation-induced preterm labor in mice. Forty sexually mature female mice were uniformly divided into four groups: sham, cervical excision, lipopolysaccharide (LPS) injection, and cervical excision plus LPS injection. Partial cervical tissue excision was performed at five weeks of age before mating. LPS was injected into the lower right uterine horn near the cervix on gestational day 16. Mice were sacrificed immediately postpartum. Uterine cervices were collected and subjected to quantitative real-time PCR. Col4α1 and Col5α1 expression increased significantly in the cervical excision plus LPS injection group compared to the sham group (p < 0.01 and p = 0.024, respectively). MMP-14 expression levels increased in the cervical excision plus LPS injection group compared to the sham group (p < 0.01). TIMP-1 expression was not significantly decreased in this group. Increased expression levels of Col4α1, Col5α1, and MMP-14 were associated with cervical excision plus inflammation-induced preterm labor. Thus, pre-gestational cervical remodeling through specific collagen metabolism and MMP activation may involve the pathogenesis of spontaneous preterm labor.

Colo do Útero/metabolismo , Trabalho de Parto Prematuro/genética , Animais , Colo do Útero/fisiologia , Colágeno/genética , Feminino , Expressão Gênica/genética , Perfilação da Expressão Gênica/métodos , Regulação da Expressão Gênica/genética , Trabalho de Parto Induzido/métodos , Metaloproteinases da Matriz/genética , Camundongos , Camundongos Endogâmicos C57BL , Gravidez , Inibidores Teciduais de Metaloproteinases/genética , Transcriptoma/genética , Útero/metabolismo
Artigo em Inglês | MEDLINE | ID: mdl-33028002


This study examined the difficulties of running online physical education classes in the context of coronavirus disease 2019 (COVID-19) and used the findings to develop an efficient operation plan to address these difficulties. Six middle and high school physical education teachers participated; three were experts in online physical education and active in the Korea Council School Physical Education Promotion, and three were recommended teachers making efforts to improve the online classes offered by the Korea Ministry of Education. A qualitative case study method employing phenomenological procedures to collect and analyze the data was used. The difficulties of operating middle and high school online physical education classes for the first time included (1) the monotony of the classes within their limited environmental conditions and limited educational content that did not adequately convey the value of physical education, (2) trial-and-error methods applied nationwide, resulting from a lack of expertise in operating online physical education classes, and (3) very limited evaluation guidelines proposed by the Korea Ministry of Education, which made systematic evaluation with online methods impossible. To address the identified problems and facilitate the efficient operation of online physical education classes, changes in strategic learning methods are needed to understand online physical education characteristics and thereby better communicate the value of physical education. It is also necessary to cultivate teaching expertise through sharing online physical education classes, where collaboration among physical education teachers is central. In addition, evaluation processes should be less formal to encourage active student participation.

Infecções por Coronavirus/prevenção & controle , Educação à Distância/organização & administração , Pandemias/prevenção & controle , Educação Física e Treinamento/métodos , Pneumonia Viral/prevenção & controle , COVID-19 , Infecções por Coronavirus/epidemiologia , Eficiência Organizacional , Humanos , Pneumonia Viral/epidemiologia , República da Coreia/epidemiologia , Instituições Acadêmicas , Estudantes/psicologia
Artigo em Inglês | MEDLINE | ID: mdl-32947940


The aim of this study was to verify the structural relationship between health perceptions, sports participation, and health promoting behavior in adolescents. A total of 507 adolescents living in Seoul, Republic of Korea, in 2020, participated in this study. This study was conducted using a preliminary survey and a main survey. In the preliminary survey, the reliability and validity of the scales used in this study were analyzed, and in the main survey, the relationships between individual variables were verified. Specifically, descriptive statistical analysis, path analysis, and mediating effect analysis were conducted in the main survey. The results of the study are as follows: first, health perceptions were found to have a positive effect on sports participation (p < 0.001). Furthermore, health perceptions were found to have no direct effect on health promoting behavior (p = 0.554), while sports participation was found to have a positive effect on health promoting behavior (p < 0.001). Additionally, sports participation completely mediated the relationship between health perceptions and health promoting behavior. Based on the results of this study, suggestions are presented on how to enhance health perceptions in adolescents who are in a critical period for forming healthy life habits, and to prepare measures to encourage sports participation.

Comportamentos Relacionados com a Saúde , Esportes , Adolescente , Feminino , Promoção da Saúde , Humanos , Masculino , Reprodutibilidade dos Testes , República da Coreia , Seul , Inquéritos e Questionários
Artigo em Inglês | MEDLINE | ID: mdl-32847040


This study aimed to develop a physical education fitness program for adolescents to counteract the declining physical activity levels caused by the COVID-19 pandemic, as well as to investigate the program's effect. This mixed-methods study developed and implemented a five-component "Music Beeps" (MB) program to promote adolescents' physical fitness. A total of 240 students from two high schools in South Korea-divided into experimental and control groups-participated in 32 sessions over 16 weeks. The changes in students' fitness were analyzed, and the educational effects were examined via inductive analysis of the observation logs and group and in-depth interviews. The results demonstrated that, whereas the comparison group demonstrated no statistically significant changes in power, muscular strength and endurance, or cardiopulmonary endurance, the experimental group showed changes in all these variables, along with changes in flexibility. Further, the MB program had significant educational effects. First, students reported that musical cues enhanced their fitness motivation and sense of responsibility. Second, record-keeping and active participation contributed to self-led fitness management. Third, activity in a small space with few pieces of equipment led to the positive perception that the program was efficient and enabled regular exercise regardless of climate conditions.

Promoção da Saúde/métodos , Música , Educação Física e Treinamento/métodos , Aptidão Física , Adolescente , COVID-19 , Infecções por Coronavirus , Exercício Físico , Humanos , Pandemias , Pneumonia Viral , República da Coreia , Instituições Acadêmicas
J Obstet Gynaecol Res ; 38(2): 449-51, 2012 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-22229956


A pregnant woman in the mid-third trimester developed complications with enlarged fetal abdomen and polyhydramnios. Prenatal ultrasound visualized dilated bowel, intraperitoneal calcifications, ascites, hydroceles and polyhydramnios, giving the impression of meconium peritonitis. The fetal abdomen continued to increased in size, and maternal dyspnea due to polyhydramnios was aggravated. She underwent a cesarean section at 36 + 1 weeks' gestation. The delivery was followed by severe neonatal respiratory distress due to the huge mass in the abdomen. The tumor was successfully removed by emergency surgery and diagnosed as immature gastric teratoma. No other associated anomaly was found. The infant made a good progress after the operation.

Síndrome do Desconforto Respiratório do Recém-Nascido/etiologia , Neoplasias Gástricas/complicações , Teratoma/complicações , Adulto , Feminino , Humanos , Recém-Nascido , Gravidez , Neoplasias Gástricas/congênito , Teratoma/congênito