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1.
Clin Appl Thromb Hemost ; 26: 1076029620932226, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32571088

RESUMO

This research was designed to determine the association of serum lipid peroxidation products with disease severity in patients with abdominal aortic aneurysm (AAA). In total, 76 pairs of AAA cases as well as matched controls were enrolled in our research using propensity score matching (PSM). And their malondialdehyde (MDA), lipid hydroperoxide (LPO), and glutathione peroxidase (GSH-Px) levels were also detected through enzyme-linked immunosorbent assay (ELISA). Additionally, the relative clinical data of enrolled participants were extracted. The serum biomarker concentrations were measured in 76 patients with AAAs (diameter between 30 and 54 mm, n = 54; diameter ≥55 mm, n = 22) and 76 control patients from observational cohort study. After PSM adjustment for clinical variables, including age, gender, heart ratio, body mass index, smoking, hypertension, diabetes mellitus, coronary heart disease, and stroke, the serum MDA and LPO among AAA cases were remarkably increased compared with those from the normal patients. Inversely, serum GSH-Px was significantly decreased in patients with AAA compared to the control group. Besides, the serum levels of MDA and LPO were independently associated with AAA risk. Typically, there was significantly positive correlation between MDA level and LPO level (R = 0.358) but negative correlation of MDA level with GSH-Px (R = -0.203) level in patients with AAA. Meanwhile, the area under the receiver operating characteristic curve was 0.965 when MDA was used to diagnose AAA, and the optimal threshold value was 0.242 nmol/mL. Moreover, serum MDA level was significantly increased in cases with rupture AAA compared to those in selective AAA cases. Logistic regression analysis suggested that a higher serum MDA level indicated an elevated risk of AAA rupture (odds ratio = 2.536; 95% CI: 1.037-6.203; P =0.041). Our present findings suggest that serum peroxidation contents were evidently changed among AAA cases. Serum MDA and LPO concentrations could be used to predict disease severity in patients with AAA. Moreover, serum MDA may serve as the candidate biomarker for diagnosis of AAA and accurate identification of increased risks of AAA rupture.

2.
Waste Manag ; 113: 80-87, 2020 Jun 04.
Artigo em Inglês | MEDLINE | ID: mdl-32505978

RESUMO

Biogas residues (BR) contaminated with potentially toxic metals pose environmental risks to soils and food chains, and strategies are needed to decrease the concentration and bioavailability of potentially toxic metals in BR. Here, metal fractions and removal mechanisms were quantified by synchrotron radiation-based Fourier transform infrared and micro X-ray fluorescence spectromicroscopies on BR and earthworms subject to vermicomposting. Vermicomposting resulted in decreases in concentrations of potentially toxic metals in BR and increases in metal removal efficiencies due to uptake by earthworms. Prior to vermicomposting, Zn, Cu and Pb were associated with N-H, O-H, aromatic C, aliphatic C, and amide functional groups, but following maturation during vermicomposting, metals were associated with N-H, O-H, aliphatic C and polysaccharide functional groups. Following vermicomposting, Zn and Cu were mainly distributed in the dermal portions of earthworms, whereas Pb was more homogeneously distributed among the inner and outer portions of the earthworms, revealing that different metals may have different uptake routes. These findings provide a new strategy for safe utilization of BR by using earthworms via vermicomposting to remove potentially toxic metals and in situ insights into how metals binding and distribution characteristics in BR and earthworms during compost and vermicomposting processes.

3.
Biol Trace Elem Res ; 2020 Jun 05.
Artigo em Inglês | MEDLINE | ID: mdl-32504399

RESUMO

Acute aortic dissection (AAD), one of the fatal diseases observed at the department of vascular surgery, is associated with a great mortality rate at the early stage. Ceruloplasmin (CP) is the plasma protein that functions as a copper transporter. The current retrospective research was carried out to assess CP contents and to examine the possible part in diagnosing patients with AAD. In addition, propensity score matching (PSM) was also utilized for reducing the bias in case screening as well as the clinical confounders. Using PSM, this study included 85 pairs of AAD cases (Stanford A and B dissection) and matched controls, and their CP levels were also detected through enzyme-linked immunosorbent assay (ELISA). Additionally, the relative clinical data were extracted from participants included in this study. After PSM adjustment for clinical variables, including gender, age, body mass index (BMI), heart ratio (HR), smoking, hypertension, diabetes mellitus, coronary heart disease (CHD), and stroke, the serum CP contents among AAD cases were remarkably increased compared with those among the normal subjects. Besides, the CP contents showed independent association with the AAD risk. Typically, the CP level was significantly positively correlated with platelet (R = 0.329) or C-reactive protein (R = 0.340) level. Meanwhile, the area under the receiver operating characteristic (ROC) curve (AUC) was 0.929 when CP was used to diagnose AAD, and the best threshold value was 36.82mg/dL. Serum CP content significantly increased in cases with thrombosed false lumen (FL) relative to those in patent FL cases. Results of logistic regression analysis suggested that a greater CP content indicated an increased thrombosed FL risk (OR = 1.11; 95% CI: 1.01-1.23; P = 0.040). Findings in this study suggest that serum ceruloplasmin contents evidently increased among acute aortic dissection cases. CP shows close correlation with the inflammatory factors among AAD cases. Further, CP may serve as the candidate biomarker to diagnose AAD and to identify an increased risk of thrombosed false lumen.

4.
J Food Sci ; 2020 Jun 07.
Artigo em Inglês | MEDLINE | ID: mdl-32506566

RESUMO

As a kind of polymer material additive, phthalic acid esters (PAEs) are widely used in food industry. However, PAEs are environmental endocrine disruptors with reproductive toxicity and teratogenic carcinogenicity, which are difficult to be degraded in the natural environment. In this paper, gas chromatography-mass spectrometer (GC-MS) methods for PAEs in polyethylene wrap film were optimized. For diisobutyl phthalate (DIBP) and dibutyl phthalate (DBP) that were mainly detected, the method had a good linearity in 1 to 500 ng/g. Then, we confirmed that the migration of DIBP and DBP from polyethylene wrap film increased with time and temperature. It is found that the migration law in different food simulations well followed the migration dynamics first-level model. The rate constant K1 and initial release rate V0 are inversely proportional to the polarity of the simulated liquid. We hope that this study can serve as a valuable reference for further research on the migration of food packing materials. PRACTICAL APPLICATION: In this paper, we present a simple example of applying migration model to evaluate the migration behaviors of PAEs in food packaging materials along with their hazardous properties. It can serve as a valuable reference for further research on the migration of food packing materials.

5.
Artigo em Inglês | MEDLINE | ID: mdl-32401489

RESUMO

Solar interfacial evaporation has been recognized as a versatile energy conversion protocol for cutting-edge applications such as water treatment and power generation (e.g., hydro voltaic effect). Recently, to enhance water evaporation rates, water temperature and evaporation area have been considered as essential ingredients, and thus photothermal materials and three-dimensional hierarchical structures have been developed to promote light-to-heat conversion efficiency and enhance interfacial evaporation. However, less attention has been paid to the airflow effect, because the interfacial floatability of photothermal membranes should be considered under air blast. Here, inspired from the stable interfacial floatability of lotus leaves, we report the airflow enhanced solar interfacial evaporation approach using a graphene-based Janus membrane. Laser-induced graphene (LIG) film was treated unilaterally by O2 plasma, forming a LIG/oxidized LIG (LIG-O) Janus membrane with distinct wettability on two sides. Higher water evaporation rate of 1.512 kg m-2 h-1 is achieved. The high solar interfacial evaporation performance can be attributed to the two advantages: (i) the combination of microscale capillary water transporting and nanoscale light trapping; (ii) hydrophobic/hydrophilic Janus membrane for stable interfacial floatability under airflow. Our approach is feasible for developing high-performance solar interfacial evaporation devices for practical clean energy utilization.

6.
Dalton Trans ; 2020 May 27.
Artigo em Inglês | MEDLINE | ID: mdl-32459270

RESUMO

Two nitrogen-rich azo-bridged porphyrin porous organic polymers (Azo-Por-Bpy-POP and Azo-Por-Dadp-POP) with high surface areas were prepared by coupling 5,10,15,20-tetra(p-nitrophenyl)-porphyrin with the aromatic amines of 2,2'-bipyridine-5,5'-diamine (Bpy) and diaminodiphenyl (Dadp). Azo-Por-Bpy-POP and Azo-Por-Dadp-POP display high photocatalytic reduction activity for CO2 to CO under visible-light irradiation without a sacrificial reagent or metal co-catalyst. Azo-Por-Bpy-POP exhibits the highest photoreduction for CO2 with CO as the only carbonaceous reduction product with a production rate of 38.75 µmol g-1 h-1. Theoretical investigations indicate a stronger electrostatic interaction between CO2 and Azo-Por-Bpy-POP than Azo-Por-Dadp-POP, which favors CO2 photoreduction.

7.
Aging (Albany NY) ; 12(9): 7818-7829, 2020 May 04.
Artigo em Inglês | MEDLINE | ID: mdl-32365052

RESUMO

OBJECTIVE: Aimed to find the cut-off point of handgrip strength and it's association with MetS. RESULTS: The relative handgrip strength was negatively associated with the prevalence of MetS. Of note, the odds ratios (ORs) with 95% confidence intervals (CIs) across tertiles of relative handgrip strength were 1 (reference), 0.45 (0.33, 0.62), and 0.13 (0.08, 0.20) in male participants after adjusting for demographic factors, calorie intake, and physical activity. Similar results were observed in female participants. The cutoff values of relative handgrip strength for male and female participants were 0.52 and 0.40, respectively. CONCLUSIONS: Findings of this study suggest that a strong relationship exists between handgrip strength and prevalence of MetS in US adults, regardless of sex. METHODS: A total of 5 056 participants in the National Health and Nutrition Examination Survey were analysed in this study. Handgrip strength was measured by using a handgrip dynamometer. MetS was defined in accordance with the criteria of the scientific statement of the American Heart Association in 2009. Multivariable binary logistic regression was used to explore the association between handgrip strength and MetS.

8.
Polymers (Basel) ; 12(3)2020 Mar 20.
Artigo em Inglês | MEDLINE | ID: mdl-32244951

RESUMO

The high speed of contaminants growth needs the burgeoning of new analytical techniques to keep up with the continuous demand for monitoring and legislation on food safety and environmental pollution control. Metal-organic frameworks (MOFs) are a kind of advanced crystal porous materials with controllable apertures, which are self-assembled by organic ligands and inorganic metal nodes. They have the merits of large specific surface areas, high porosity and the diversity of structures and functions. Latterly, the utilization of metal-organic frameworks has attracted much attention in environmental protection and the food industry. MOFs have exhibited great value as sensing materials for many targets. Among many sensing methods, fluorometric sensing is one of the widely studied methods in the detection of harmful substances in food and environmental samples. Fluorometric detection based on MOFs and its functional materials is currently one of the most key research subjects in the food and environmental fields. It has gradually become a hot research direction to construct the highly sensitive rapid sensors to detect harmful substances in the food matrix based on metal-organic frameworks. In this paper, we introduced the synthesis and detection application characteristics (absorption, fluorescence, etc.) of metal-organic frameworks. We summarized their applications in the MOFs-based fluorometric detection of harmful substances in food and water over the past few years. The harmful substances mainly include heavy metals, organic pollutants and other small molecules, etc. On this basis, the future development and possible application of the MOFs have prospected in this review paper.

9.
ACS Nano ; 14(4): 4196-4205, 2020 Apr 28.
Artigo em Inglês | MEDLINE | ID: mdl-32298573

RESUMO

Ligand-induced chirality in semiconducting nanocrystals has been the subject of extensive study in the past few years and shows potential applications in optics and biology. Yet, the origin of the chiroptical effect in semiconductor nanoparticles is still not fully understood. Here, we examine the effect of the interaction with amino acids on both the fluorescence and the optical activity of chiral semiconductor quantum dots (QDs). A significant fluorescence enhancement is observed for l/d-Cys-CdTe QDs upon interaction with all the tested amino acids, indicating suppression of nonradiative pathways as well as the passivation of surface trap sites brought via the interaction of the amino group with the CdTe QDs' surface. Heterochiral amino acids are shown to weaken the circular dichroism (CD) signal, which may be attributed to a different binding configuration of cysteine molecules on the QDs' surface. Furthermore, a red shift of both CD and fluorescence signals in l/d-Cys-CdTe QDs is only observed upon adding cysteine, while other tested amino acids do not exhibit such an effect. We speculate that the thiol group induces orbital hybridization of the highest occupied molecular orbital (HOMOs) of cysteine and the valence band of CdTe QDs, leading to the decrease of the energy band gap and a concomitant red shift of CD and fluorescence spectra. This is further verified by density functional theory calculations. Both the experimental and theoretical findings indicate that the addition of ligands that do not "directly" interact with the valence band (VB) of the QD (noncysteine moieties) changes the QD photophysical properties, as it probably modifies the way cysteine is bound to the surface. Hence, we conclude that it is not only the chemistry of the amino acid ligand that affects both CD and PL but also the exact geometry of binding that modifies these properties. Understanding the relationship between the QD's surface and chiral amino acid thus provides an additional perspective on the fundamental origin of induced chiroptical effects in semiconductor nanoparticles, potentially enabling us to optimize the design of chiral semiconductor QDs for chiroptic applications.

10.
Artigo em Inglês | MEDLINE | ID: mdl-32348118

RESUMO

High-performance thermal management materials are essential in miniaturized, highly integrated, and high-power modern electronics for heat dissipation. In this context, the large interface thermal resistance (ITR) that occurs between fillers and the organic matrix in polymer-based nanocomposites greatly limits their thermal conductive performance. Herein, through-plane direction aligned three-dimensional (3D) MXene/silver (Ag) aerogels are designed as heat transferring skeletons for epoxy nanocomposites. Ag nanoparticles (NPs) were in situ decorated on exfoliated MXene nanosheets to ensure good contact, and subsequent welding of ice-templated MXene/Ag nanofillers at low temperature of ∼200 °C reduced contact resistance between individual MXene sheets. Monte Carlo simulations suggest that thermal interficial resistance (R0) of the MXene/Ag-epoxy nanocomposite was 4.5 × 10-7 m2 W-1 K-1, which was less than that of the MXene-epoxy nanocomposite (Rc = 5.2 × 10-7 m2 W-1 K-1). Furthermore, a large-scale atomic/molecular massively parallel simulator was employed to calculate the interfacial resistance. It was found that RMXene = 2.4 × 10-9 m2 K W-1, and RMXene-Ag = 2.0 ×10-9 m2 K W-1, respectively, indicating that the Ag NP enhanced the interfacial heat transport. At a relatively low loading of 15.1 vol %, through-plane thermal conductivity reached a value as high as 2.65 W m-1 K-1, which is 1225 % higher than that of pure epoxy resin. Furthermore, MXene/Ag-epoxy nanocomposite film exhibits an impressive thermal conductive property when applied on a Millet 8 and Dell computer for heat dissipation.

11.
Rev Cardiovasc Med ; 21(1): 75-92, 2020 Mar 30.
Artigo em Inglês | MEDLINE | ID: mdl-32259906

RESUMO

Abdominal aortic aneurysms (AAA) are life-threatening serious conditions that require effective and quick management. Although it is generally acknowledged that patients with AAA obtain the greatest benefit from endovascular repair (EVAR) compared to open surgical repair (OSR), there are few comparisons between the surgical approaches in Western versus Chinese patients. We aimed to perform a meta-analysis of studies in which EVAR was compared with OSR in the management of abdominal aortic aneurysms. We searched the Western literature through PubMed, OVID and Web of Science from 1991 until December 2018 and the Chinese-language literature from 1998 until December 2018. We pooled the results in January 2019 based on standardized inclusion and exclusion criteria and analyzed them using a conventional meta-analysis. Forty-five English papers with 31,074 AAA patients and twenty-one Chinese studies with 1,405 patients were included in this study. Chinese subjects were more likely to undergo endovascular repair than Western subjects (44.5% versus 41.5%, P = 0.012). The 30-day post-discharge mortality rate in Western studies was significantly lower for EVAR than for OSR (odds ratio (OR) = 0.481, P < 0.001). However, there was no significant reduction in the 30-day mortality rate following EVAR compared to OSR (OR = 0.733, P = 0.425) for Chinese patients. In Western patients, the postoperative complication rate of respiratory system and cardiac system was lower in the EVAR group than in the OSR group (OR = 0.270, P < 0.001 and OR = 0.411, P < 0.001, respectively), nevertheless, for Chinese patients, limb ischaemia was more common (OR = 1.539, P = 0.049) in the EVAR group. Whether in Western patients with an eight-year follow-up period or Chinese patients with a maximum four-year follow-up period, there was no significant difference between the EVAR and OSR groups in the all-cause death rate (hazard ratio (HR) = 1.026, P = 0.483 and HR = 1.173, P = 0.247, respectively). Chinese patients were more likely to receive EVAR than OSR and the 30-day mortality was significantly lower for EVAR than for OSR in Western patients but not in Chinese patients. Endovascular repair can be applied to Chinese patients with a reasonable safety margin. Further work is needed to explore the causes of these treatment differences.

12.
Artigo em Inglês | MEDLINE | ID: mdl-32249563

RESUMO

The grain boundaries of perovskite polycrystalline are regarded as a defect region that not only provides carrier recombination sites but also introduces device degradation pathways. Efforts to enlarging the grain size of a perovskite film and reducing its grain boundary are crucial for highly efficient and stable perovskite solar cells (PSCs). Some effective methods that facilitate grain growth are postdeposition thermal annealing and solvent vapor annealing. However, a detailed understanding of grain growth mechanisms in perovskite films is lacking. In this study, perovskite films were prepared by adding ethylamine hydrochloride (EACl) to the precursor solution. This additive strategy promotes a new grain growth mode, secondary grain growth, in perovskite films. Secondary grain growth leads to much larger grains with a high crystallographic orientation. These excellent properties lead to reduced grain boundaries and the densities of boundary defects. The improved film quality results in a prolonged charge-carrier lifetime and a significantly enhanced power conversion efficiency (PCE). Compared with the 18.42% PCE of the control device, the PCE of the device with EACl additives reaches 21.07%.

13.
Med Sci Monit ; 26: e920666, 2020 Apr 07.
Artigo em Inglês | MEDLINE | ID: mdl-32253370

RESUMO

BACKGROUND Aging is characterized by progressive deterioration in metabolic and physiological process. The present research assessed the antagonistic effects and mechanisms of Ginsenoside Rg1 (Rg1) on aging of HSCs/HPCs. MATERIAL AND METHODS Fifty male Sprague-Dawley (SD) rats were treated and divided into the following groups: Control (n=10), Model (n=10, treated with D-galactose, as aging model), Rg1 Control (n=10), Rg1 treatment (n=10), and Rg1 prevention (n=10). An aging rat model was established by subcutaneous injection with D-gal. HSC/HPC cells were stained using SA-ß-Gal staining. HSC/HPC cells were examined using flow cytometry assay. CFU-mix assay, with a few modifications, was performed. Cleaved caspase-3, B-cell lymphoma-2 (Bcl-2), and Bcl-2-associated X protein (Bax) were examined using qRT-PCR. Sirtuin 3 (SIRT3) and superoxide dismutase 2 (SOD2) expression was determined using Western blot assay and qRT-PCR. RESULTS Rg1 (treatment and prevention group) significantly decreased SA-ß-Gal-positive staining in Sca-1⁺ HSC/HPC cells compared to that of the D-gal model (p<0.05). Rg1 significantly enhanced formation capacity of CFU-Mix compared to the D-gal model (p<0.05) in Sca-1⁺ HSC/HPC cells. Rg1 significantly reduced G0/G1 phase of Sca-1⁺ HSC/HPC cells compared to that of the D-gal model (p<0.05). Rg1 significantly decreased cleaved caspase 3 and Bax expression, and increased Bcl-2 expression compared to the D-gal model (p<0.05). Rg1 treatment remarkably upregulated expressions of SIRT3 and SOD2 compared to that of the D-gal model group (p<0.05). CONCLUSIONS Rg1 conducted functions of anti-aging in Sca-1⁺ HSC/HPC cells in the D-gal-induced aging model by inhibiting mitochondrial pathway-mediated apoptosis and activating the SIRT3/SOD2 signaling pathway.

14.
Arch Microbiol ; 2020 Apr 25.
Artigo em Inglês | MEDLINE | ID: mdl-32335717

RESUMO

ß-glucanases are widely applied in biological control, brewing and feed industries; however, there are seldom studies of ß-glucanases in probiotics. Here, ß-glucanase genes were cloned from Bacillus licheniformis, Lactobacillus fermentum and L. johnsonii. ß-glucanase genes, as blg, lfg and ljg isolated from B. licheniformis, L. fermentum and L. johnsonii were prokaryotic expressed to obtain recombinant strains BL, LF and LJ, respectively. Directed mutations in these genes were introduced by sequential error-prone PCR. Results showed that ß-glucanase activities in three mutants mblg, mlfg and mljg were 1.94-, 2.72- and 1.29-fold higher than the BL, LF and LJ, respectively. Mutation sites analysis showed substitutions at Ser370Gly and Leu395Phe in mblg; Arg169His and Asn302Ser in mlfg; Val132Met, Ser226Asn, and Asp355Gly in mljg. Spatial structural predictions revealed the numbers and positions of α-helices and ß-strands in the three mutants were altered, which might result in ß-glucanase activity increasement. Analysis of ß-glucanase properties revealed no significant differences in the optimal temperatures and pH between mutant and wild-type strains. However, mlfg and mljg exhibited greater thermal stability at 30-50 â„ƒ than the wild-type strains, and mblg improved pH stability compared with wild-type strain. This is the first report about ß-glucanase-encoding genes in L. fermentum and L. johnsonii. These findings provide an efficient way to improve the activity of ß-glucanase.

15.
Dermatol Ther ; : e13310, 2020 Mar 13.
Artigo em Inglês | MEDLINE | ID: mdl-32170800

RESUMO

Health professions preventing and controlling Coronavirus Disease 2019 are prone to skin and mucous membrane injury, which may cause acute and chronic dermatitis, secondary infection and aggravation of underlying skin diseases. This is a consensus of Chinese experts on protective measures and advice on hand-cleaning- and medical-glove-related hand protection, mask- and goggles-related face protection, UV-related protection, eye protection, nasal and oral mucosa protection, outer ear, and hair protection. It is necessary to strictly follow standards of wearing protective equipment and specification of sterilizing and cleaning. Insufficient and excessive protection will have adverse effects on the skin and mucous membrane barrier. At the same time, using moisturizing products is highly recommended to achieve better protection.

16.
J Affect Disord ; 269: 12-17, 2020 May 15.
Artigo em Inglês | MEDLINE | ID: mdl-32217338

RESUMO

BACKGROUND: The longitudinal associations between handgrip strength (HGS) and depressive symptoms remain unclear, especially in developing countries. The aim of this cohort study was to explore the associations between HGS and the incidence of depressive symptoms in China. METHODS: This prospective cohort study enrolled 8470 participants living in 450 urban communities and rural villages within 28 provinces of China. Depressive symptoms were assessed using the 10-item Center for Epidemiological Studies Depression Scale. Cox proportional hazards regression models were used to examine the associations between baseline HGS and the incidence of depressive symptoms. RESULTS: During the following period (mean follow-up, 3.75 years; 95% confidence interval [CI], 3.73-3.76 years), 2,027 (23.93%) out of 8470 participants developed depressive symptoms. The risk of depressive symptoms decreased progressively with both increasing weighted HGS (P for trend = 0.04) and absolute HGS (P for trend < 0.001) after multivariate-adjustments. Compared with participants in the lowest quartiles of weighted and absolute HGS, the multivariate-adjusted hazard ratios (HRs) (95% CIs) of depressive symptoms for participants in the highest quartiles were 0.83 (0.71, 0.98) and 0.74 (0.62, 0.89), respectively. The interaction terms of weighted HGS-place of residence (P for interaction < 0.001) and absolute HGS-place of residence (P for interaction = 0.03) were both significant. Higher weighted and absolute HGS were associated with a lower incidence of depressive symptoms for participants living in rural villages but not urban communities. CONCLUSIONS: The results suggest that HGS predicts a lower risk of depressive symptoms in Chinese rural populations.

17.
Phlebology ; : 268355519897650, 2020 Feb 09.
Artigo em Inglês | MEDLINE | ID: mdl-32036737

RESUMO

OBJECTIVE: Venous thromboembolism, including deep vein thrombosis and pulmonary embolism, is likely to cause the death of both medical and surgical patients. Despite some evidence of seasonal variation in the incidence of venous thromboembolism, the existing studies obtain contradictory results. A temporal pattern for pulmonary embolism is known, but data on deep vein thrombosis are inconclusive. The purpose of this study is to make a meta-analysis and systematically review the literature about seasonal variations of pulmonary embolism and/or deep vein thrombosis in order to objectively diagnose venous thromboembolism. METHODS: According to dichotomous data, risk ratios (RRs) and 95% confidence intervals (CIs) were used to compare the incidence of venous thromboembolism in different seasons. The research was classified according to pulmonary embolism mortality, pulmonary embolism/deep vein thrombosis incidence, latitude/elevation/climatic types, and monthly incidence for four subgroup comparisons. There were a total of 23 eligible studies, in which 40,309 patients with venous thromboembolism were compared. RESULTS: The pooled total venous thromboembolism incidence was 27.2% in winter, 23.1% in spring, 24.6% in summer, and 25.1% in autumn. According to the results of pooled analysis, the incidence of venous thromboembolism in winter was much higher than that in summer (RR = 1.12, 95% CI: 1.01-1.24, adjusted P = .04), especially deep vein thrombosis. Moreover, the incidence of venous thromboembolism in summer and autumn was lower than that in winter in low-latitude (<200 m) areas and median low-latitude (0-50°-N) areas. Interestingly, the frequency of pulmonary embolism mortality was the largest in spring and smallest in summer (spring > winter ≈ autumn > summer). For monthly data, a statistically significantly lower incidence of venous thromboembolism was observed in May and July than in October. CONCLUSIONS: The study revealed a significantly higher incidence of venous thromboembolism and deep vein thrombosis in winter than in summer. Pulmonary embolism mortality occurred more frequently in spring than during other seasons. A statistically significantly lower incidence of venous thromboembolism was observed in May and July compared with that in October.

18.
J Clin Periodontol ; 47(6): 777-785, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32096243

RESUMO

INTRODUCTION: This study is an extended follow-up of a randomized controlled trial that evaluated 18-month outcomes following free gingival grafts (FGGs) around implants with <2 mm keratinized mucosa (KM) compared to implants without KM augmentation. MATERIALS AND METHODS: Follow-up data were obtained over 48 months from 18 implants in the FGG group (11 subjects) and 8 implants in the no-surgery group (7 subjects) within the control group. FGGs were performed after 18 months for 8 implants in the control group; these 8 implants constituted a delayed FGG group (5 subjects). The width of KM, mucosal recession (MR) and crestal bone level (CBL) were obtained. RESULTS: The increased width of KM and the reduced MR following FGGs were maintained for 48 months in the FGG group, which exhibited less MR than the no-surgery group. The amount of crestal bone loss (0.4 ± 0.4 mm) in the no-surgery group was significantly greater than that in the FGG group (0 ± 0.4 mm) at 48 months. In the delayed FGG group, reduced MR and no significant differences in CBL were observed compared with the pre-graft measurements. CONCLUSIONS: FGGs can be a practical treatment option to maintain CBL around implants with limited KM.

20.
Aging (Albany NY) ; 12(1): 309-317, 2020 01 03.
Artigo em Inglês | MEDLINE | ID: mdl-31899685

RESUMO

OBJECTIVE: This study aimed to determine whether changes in sleep duration are associated with a higher risk of mild cognitive impairment (MCI) in older adults. RESULTS: By the 3-year follow-up, 592 participants developed MCI. Compared with the individuals who had an unchanged sleep duration, the odds ratio (95% confidence interval) for MCI was 1.44 (1.08-1.91) for those whose sleep duration increased by ≥2 h after multivariate adjustments. Moreover, changing from a long to moderate, but not short, sleep duration was negatively associated with the incidence of MCI (odds ratio: 0.65; 95% confidence interval, 0.45-0.93). CONCLUSIONS: These findings suggest that increased sleep duration is associated with a higher risk of MCI in the elderly. Furthermore, a moderate duration of sleep (6-9 h) could serve as a possible strategy for prevention of MCI. METHODS: This longitudinal study was conducted with a nationally representative sample of 5419 older Chinese adults (≥65 years) from the 2008 and 2011 waves of the Chinese Longitudinal Healthy Longevity Survey. Sleep duration was assessed by a self-administered questionnaire. MCI was defined according to the Mini-Mental State Examination. An adjusted logistic regression model was used to explore the associations between changes in sleep duration and MCI.

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