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1.
Huan Jing Ke Xue ; 43(1): 123-131, 2022 Jan 08.
Artigo em Chinês | MEDLINE | ID: mdl-34989496

RESUMO

A continuous observation campaign was carried out with the Syntech Spectras GC955 volatile organics online monitoring system from December 1, 2019 to March 31, 2020 during the COVID-19 period in Hangzhou. Composition characteristics, diurnal variation, and atmospheric chemical reactivity of VOCs were analyzed. The results showed that φ(total VOCs) were the highest before the COVID-19 pandemic in different sites and the lowest during the first response period. The φ(total VOCs) at night was higher than that during the day. The daily variation in Wolongqiao φ(total VOCs) was less than that in Xiasha. The daily variation in φ(total VOCs) during the first level response period was less than that during the other three periods. The diurnal variation in the φ (total VOCs) in Xiasha showed a "V" shape, and that in Wolongqiao showed a typical bimodal structure. The OFP in Xiasha was higher than that in Wolongqiao. The OFP were the highest at the two sites before the COVID-19 pandemic. The OFP was the lowest during the first response period in Xiasha and the lowest during the second response period in Wolongqiao. The OFP of aromatics and olefins was higher, and the OFP of alkynes was the lowest in Xiasha. The OFP of olefin in Wolongqiao was much higher than that of the other three components, followed by alkane and alkyne.


Assuntos
Poluentes Atmosféricos , COVID-19 , Ozônio , Compostos Orgânicos Voláteis , Poluentes Atmosféricos/análise , China , Monitoramento Ambiental , Humanos , Ozônio/análise , Pandemias , SARS-CoV-2 , Compostos Orgânicos Voláteis/análise
2.
ACS Biomater Sci Eng ; 2022 Jan 05.
Artigo em Inglês | MEDLINE | ID: mdl-34984904

RESUMO

Subperiosteal implants represent an alternative implant approach for cases with severe bone atrophy. Although some successful clinical cases have been reported, the biomechanical stability of subperiosteal implants remains unclear, and more data are needed to confirm the feasibility of this approach. Therefore, this study investigated the biomechanical characteristics of subperiosteal implants based on histological observation, clinical cases, and finite element analysis. Finite element analysis indicated that subperiosteal implants with a lattice-like structure could better disperse the stress to the underlying bone surface. A novel customized subperiosteal implant was then digitally designed and fabricated using an additive manufacturing technology. Six beagle dogs received such customized subperiosteal implants. Histological and microcomputed tomography examination showed new bone growth into and around the implant. Patient-specific subperiosteal implants were placed into the edentulous mandibular bone, with immediate loading. The implant was functional, without pain or infection, over a 12 month observation period. Images taken 12 months post-operatively showed new bone formation and osseointegration of the device. This indicated that 3D-printed lattice-like subperiosteal implants have sufficient stability for the rehabilitation of severely atrophic ridges.

3.
J Pharm Biomed Anal ; 209: 114516, 2021 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-34894463

RESUMO

Consistently, the multiple heart-kidney interactions make pharmaceutical research for cardiorenal syndrome difficult and complex. Guanxinning Injection (GXN) has been reported to provide unique advantage for treating cardiac and renal diseases compared to typical monotherapies. However, the protection mechanism of GXN is largely unknown. This study explored the acting mechanism of GXN on heart failure with renal dysfunction from a metabolic perspective. Transverse aortic constriction (TAC) surgery was performed on C57/BL/6 mice to induce heart failure with renal dysfunction. Using telmisartan as a positive control, GXN treatment was applied during the 12th to 16th week after TAC. Cardiac function and structure were examined using M-mode echocardiography, and renal function was evaluated via representative biochemical parameters and hematoxylin-eosin staining. Moreover, untargeted metabolomic analyses of urine were conducted to screen for differential substances associated with the cardiorenal protection effect of GXN. As a result, GXN provided good cardioprotective effects on left ventricular ejection fraction elevation, fractional shortening, internal diastolic, and mass maintenance. GXN also reduced TAC-induced elevation of blood urea nitrogen, and serum Cystatin C and relieved kidney pathological damage. Metabolomic analyses identified 21 differential metabolites in the TAC model group. Ten metabolites involving the metabolic pathways of carnitine synthesis, valine, leucine and isoleucine degradation, and glutamate metabolism, taurine and hypotaurine metabolism, tryptophan metabolism, arginine and proline metabolism, and purine metabolism were restored by GXN. The main cardiorenal protection mechanism of GXN was found to be related to energy metabolism and oxidative stress. Taken together, this study provides the first evidence of the metabolic protection mechanism of GXN on heart failure with renal dysfunction for the first time and provides a research basis for the application of GXN in CRS-2 pharmaceuticals.

4.
Microb Cell Fact ; 20(1): 229, 2021 Dec 23.
Artigo em Inglês | MEDLINE | ID: mdl-34949197

RESUMO

BACKGROUND: Steroid drugs are essential for disease prevention and clinical treatment. However, due to intricated steroid structure, traditional chemical methods are rarely implemented into the whole synthetic process for generating steroid intermediates. Novel steroid drug precursors and their ideal bacterial strains for industrial production have yet to be developed. Among these, 9,21-dihydroxy-20-methyl-pregna-4-en-3-one (9-OH-4-HP) is a novel steroid drug precursor, suitable for the synthesis of corticosteroids. In this study, a combined strategy of blocking Δ1-dehydrogenation and the C19 pathway as well as improving the intracellular environment was investigated to construct an effective 9-OH-4-HP-producing strain. RESULTS: The Δ1-dehydrogenation-deficient strain of wild-type Mycobacterium neoaurum DSM 44074 produces 9-OH-4-HP with a molar yield of 4.8%. Hsd4A, encoding a ß-hydroxyacyl-CoA dehydrogenase, and fadA5, encoding an acyl-CoA thiolase, were separately knocked out to block the C19 pathway in the Δ1-dehydrogenation-deficient strain. The two engineered strains were able to accumulate 0.59 g L-1 and 0.47 g L-1 9-OH-4-HP from 1 g L-1 phytosterols, respectively. Furthermore, hsd4A and fadA5 were knocked out simultaneously in the Δ1-dehydrogenation-deficient strain. The 9-OH-4-HP production from the Hsd4A and FadA5 deficient strain was 11.9% higher than that of the Hsd4A deficient strain and 40.4% higher than that of the strain with FadA5 deficiency strain, respectively. The purity of 9-OH-4-HP obtained from the Hsd4A and FadA5 deficient strain has reached 94.9%. Subsequently, the catalase katE from Mycobacterium neoaurum and an NADH oxidase, nox, from Bacillus subtilis were overexpressed to improve the intracellular environment, leading to a higher 9-OH-4-HP production. Ultimately, 9-OH-4-HP production reached 3.58 g L-1 from 5 g L-1 phytosterols, and the purity of 9-OH-4-HP improved to 97%. The final 9-OH-4-HP production strain showed the best molar yield of 85.5%, compared with the previous reported strain with 30% molar yield of 9-OH-4-HP. CONCLUSION: KstD, Hsd4A, and FadA5 are key enzymes for phytosterol side-chain degradation in the C19 pathway. Double deletion of hsd4A and fadA5 contributes to the blockage of the C19 pathway. Improving the intracellular environment of Mycobacterium neoaurum during phytosterol bioconversion could accelerate the conversion process and enhance the productivity of target sterol derivatives.

5.
Zhongguo Zhen Jiu ; 41(12): 1405-8, 2021 Dec 12.
Artigo em Chinês | MEDLINE | ID: mdl-34936283

RESUMO

The published literature of insomnia in the elderly treated with acupuncture was retrieved in CNKI, Wanfang and VIP from the date of establishment to December 31, 2019. Association rule analysis and cluster analysis were used to summarize the acupoint selection rules of insomnia in the elderly treated with acupuncture. A total of 37 articles were included, involving 60 acupuncture prescriptions. The most commonly used acupoints were Sanyinjiao (SP 6), Shenmen (HT 7), Anmian (Extra), Baihui (GV 20), Sishencong (EX-HN 1), Neiguan (PC 6), Xinshu (BL 15) and Taixi (KI 3). The most commonly used acupoint combinations were Sanyinjiao (SP 6)-Anmian (Extra)-Baihui (GV 20)-Sishencong (EX-HN 1)-Shenting (GV 24)-Shenmen (HT 7)-Xinshu(BL 15), Xinshu(BL 15)-Pishu (BL 20)-Shenshu (BL 23)-Shenting (GV 24), Zhaohai (KI 6)-Shenmai (BL 62), Taichong (LR 3)-Ganshu (BL 18), Daling (PC 7)-Taixi (KI 3), Neiguan (PC 6)- Zusanli (ST 36) and Guanyuan (CV 4)-Qihai (CV 6)-Zhongwan (CV 12). On the basis of acupoint selection according to disease differentiation, the acupoint selection rules and characteristics of insomnia in the elderly treated with acupuncture are regulating and supplementing the spleen and kidney and treating according to spleen-kidney.


Assuntos
Terapia por Acupuntura , Distúrbios do Início e da Manutenção do Sono , Pontos de Acupuntura , Idoso , Diferenciação Celular , Humanos , Publicações , Distúrbios do Início e da Manutenção do Sono/terapia
6.
Adv Mater ; : e2108430, 2021 Dec 18.
Artigo em Inglês | MEDLINE | ID: mdl-34921569

RESUMO

The regeneration of diabetic bone defects remains challenging as the innate healing process is impaired by glucose fluctuation (GF), reactive oxygen species (ROS) and over-expression of proteinases (such as matrix metalloproteinases, MMPs). A "diagnostic" and therapeutic dual logic-based hydrogel for diabetic bone regeneration is therefore developed through the design of a double-network hydrogel consisting of phenyboronic acid-crosslinked polyvinyl alcohol and gelatin colloids. It exhibited a "diagnostic" logic to interpret pathological cues (GF, ROS, MMPs) and determine when to release drug in a diabetic microenvironment and a therapeutic logic to program different cargo release to match immune-osteo cascade for better tissue regeneration. The hydrogel was also shown to be mechanically adaptable to the local complexity at the bone defect. Furthermore, the underlying therapeutic mechanism was elucidated whereby the logic-based cargo release enabled the regulation of macrophage polarization by remodeling the mitochondria-related antioxidative system, resulting in enhanced osteogenesis in diabetic bone defects. In conclusion, our study provides critical insight into the design and biological mechanism of dual logic-based tissue engineering strategies for diabetic bone regeneration. This article is protected by copyright. All rights reserved.

7.
Cancer Sci ; 2021 Dec 20.
Artigo em Inglês | MEDLINE | ID: mdl-34927309

RESUMO

How to improve the clinical efficacy and enlarge the benefit population of immune checkpoint inhibitors (ICIs) for non-small cell lung cancer (NSCLC) remains a big challenge. Based on the whole-exosome sequencing analysis of the biopsies from NSCLC patients before anti-PD-1 treatment, we have identified NLRP4 mutations in the responders with a longer progression free survival (PFS). Knockdown of NLRP4 in mouse lewis lung cancer cell line enhanced IFN-α/ß production via cGAS-STING-IRF3/IRF7 axis and promoted the accumulation of intra-tumoral CD8+ T cells, leading to tumor growth retardation in vivo and a synergistic effect with anti-PD-L1 therapy. This was consistent with clinical observations that more tumor-infiltrating CD8+ T cells and elevated peripheral IFN-α before receiving nivolumab treatment were associated with a longer PFS in NSCLC patients. Our study highlights the roles of tumor-intrinsic NLRP4 in remodeling the immune contextures in the tumor microenvironment, making regional type I interferon beneficial for ICI treatment.

8.
Int J Gen Med ; 14: 8007-8018, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34785943

RESUMO

Objective: To evaluate the clinical value of qualitative shear wave elastography (SWE) color in the differential diagnosis of benign and malignant thyroid nodules. Methods: From January 2017 to July 2018, 241 patients with 261 thyroid nodules, who underwent conventional ultrasonography and SWE examination before surgical resection, were enrolled. The nodules were also evaluated by histopathologic analyses. The SWE color characteristics that could differentiate malignant and benign thyroid nodules were selected and scored based on the malignancy rate. The diagnostic performances were evaluated by receiver operating characteristic (ROC) curves analysis. Results: Among the 261 thyroid nodules, 58 were benign, and 203 were malignant. Malignancy was associated with orange or red as the color of maximum hardness inside a nodule, green as the primary color, with a "stiff rim," inhomogeneous internal color, and inhomogeneous color between the nodules and its surrounding areas. The SWE color scores for benign thyroid nodules were mainly 0 and 1, while 4 and 5 were for malignant thyroid nodules. The area under the ROC curve (AUC) of the SWE color score ≥3 for the diagnosis of malignant thyroid nodules was 0.828 (95% CI: 0.764, 0.891) with a sensitivity of 82.8%, a specificity of 82.8%, and an accuracy of 83.1%. Additionally, conventional ultrasound combined with SWE color scores had a higher diagnostic performance than conventional ultrasound (AUC 0.820 vs AUC 0.796, P = 0.04). Conclusion: The SWE color scores might be a convenient and effective method to assist in differentiating thyroid nodules.

10.
Transl Psychiatry ; 11(1): 568, 2021 Nov 08.
Artigo em Inglês | MEDLINE | ID: mdl-34744165

RESUMO

Major depressive disorder (MDD) is a serious mental illness. Increasing evidence from both animal and human studies suggested that the gut microbiota might be involved in the onset of depression via the gut-brain axis. However, the mechanism in depression remains unclear. To explore the protein changes of the gut-brain axis modulated by gut microbiota, germ-free mice were transplanted with gut microbiota from MDD patients to induce depression-like behaviors. Behavioral tests were performed following fecal microbiota transplantation. A quantitative proteomics approach was used to examine changes in protein expression in the prefrontal cortex (PFC), liver, cecum, and serum. Then differential protein analysis and weighted gene coexpression network analysis were used to identify microbiota-related protein modules. Our results suggested that gut microbiota induced the alteration of protein expression levels in multiple tissues of the gut-brain axis in mice with depression-like phenotype, and these changes of the PFC and liver were model specific compared to chronic stress models. Gene ontology enrichment analysis revealed that the protein changes of the gut-brain axis were involved in a variety of biological functions, including metabolic process and inflammatory response, in which energy metabolism is the core change of the protein network. Our data provide clues for future studies in the gut-brain axis on protein level and deepen the understanding of how gut microbiota cause depression-like behaviors.

11.
Cell Rep ; 37(5): 109910, 2021 Nov 02.
Artigo em Inglês | MEDLINE | ID: mdl-34731606

RESUMO

RBFOX2, which has a well-established role in alternative splicing, is linked to heart diseases. However, it is unclear whether RBFOX2 has other roles in RNA processing that can influence gene expression in muscle cells, contributing to heart disease. Here, we employ both 3'-end and nanopore cDNA sequencing to reveal a previously unrecognized role for RBFOX2 in maintaining alternative polyadenylation (APA) signatures in myoblasts. RBFOX2-mediated APA modulates mRNA levels and/or isoform expression of a collection of genes, including contractile and mitochondrial genes. Depletion of RBFOX2 adversely affects mitochondrial health in myoblasts, correlating with disrupted APA of mitochondrial gene Slc25a4. Mechanistically, RBFOX2 regulation of Slc25a4 APA is mediated through consensus RBFOX2 binding motifs near the distal polyadenylation site, enforcing the use of the proximal polyadenylation site. In sum, our results unveil a role for RBFOX2 in fine-tuning expression of mitochondrial and contractile genes via APA in myoblasts relevant to heart diseases.

12.
Mol Immunol ; 140: 196-205, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-34735868

RESUMO

BACKGROUND: Gastric cancer (GC) derived exosomes (Exos) aggravate GC development by facilitating M2 macrophage polarization and long non-coding RNA (lncRNA) HCG18 was highly expressed in GC. This study aimed to investigate whether the exosomal lncRNA HCG18 regulated the M2 macrophage polarization in GC and the possible mechanism. METHODS: The isolated GC cells (GCCs)-Exos were identified using transmission electron microscopy, Nanoparticle Tracking Analysis and Western blot. The GCCs-Exos function was verified by enzyme-linked immunosorbent assay and flow cytometry. Meanwhile, the exosomal lncRNA HCG18 function was determined using thein vitro assays. Furthermore, the underlying mechanism of the exosomal lncRNA HCG18 that regulated M2 macrophage polarization in GC was investigated using dual-luciferase reporter gene assay and RNA pull-down. RESULTS: After the validation of GCCs-Exos, the GCCs-Exos facilitated the M2 macrophage polarization. The in vitro assays confirmed that the exosomal lncRNA HCG18 positively regulated the M2 macrophage polarization. Mechanistically, lncRNA HCG18 bound to miR-875-3p, miR-875-3p bound to KLF4. Furthermore, GCCs-exosomal lncRNA HCG18 elevated the KLF4 expression by decreasing miR-875-3p in macrophages to facilitate M2 macrophage polarization, thus alleviating GC. The in vivo assays clarified that the GCCs-exosomal lncRNA HCG18 restrained the tumor growth of GC induced by M2 macrophages. CONCLUSION: GCCs-exosomal lncRNA HCG18 elevated KLF4 expression by decreasing miR-875-3p in macrophages to facilitate the M2 macrophage polarization.

13.
Front Oncol ; 11: 725211, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34737948

RESUMO

Early diagnosis and treatment of colorectal cancer (CRC) significantly improves the survival rate and quality of life. Here we screened for differences in glycoproteins associated with tumor-derived exosomes and validated their clinical value to serve as liquid biopsy biomarkers to diagnosed early CRC. Exosomes were extracted from paracancerous tissues, cancer tissues, and plasma. LC-MS/MS proteomic and glycoproteomics analyses were performed using an LTQ-Orbitrap Elite mass spectrometer. The differences in glycoproteins associated with exosomes of paracancerous tissues and cancer tissue were determined, and their levels in plasma exosomes were determined. Statistical analysis was performed to evaluate the diagnostic efficacy of exosome-associated glycoproteins for CRC. We found that the levels of fibrinogen beta chain (FGB) and beta-2-glycoprotein 1 (ß2-GP1) in the exosome of CRC tissue were significantly higher compared with those of paracancerous tissues exosome. The areas under the receiver operating characteristic (ROC) curves of plasma exosomal FGB and ß2-GP1 as biomarkers for CRC were 0.871 (95% CI = 0.786-0.914) and 0.834 (95% CI = 0.734-0.901), respectively, compared with those of the concentrations of carcinoembryonic antigen concentration [0.723 (95% CI = 0.679-0.853)] and carbohydrate antigen19-9 concentration [0.614 (95% CI = 0.543-0.715)]. Comprehensive proteomics analyses of plasma exosomal biomarkers in CRC identified biomarkers with significant diagnostic efficacy for early CRC, which can be measured using relatively non-invasive techniques.

14.
Cancer Res ; 81(22): 5638-5651, 2021 Nov 15.
Artigo em Inglês | MEDLINE | ID: mdl-34607841

RESUMO

The majority of human genes have multiple polyadenylation sites, which are differentially used through the process of alternative polyadenylation (APA). Dysregulation of APA contributes to numerous diseases, including cancer. However, specific genes subject to APA that impact oncogenesis have not been well characterized, and many cancer APA landscapes remain underexplored. Here, we used dynamic analyses of APA from RNA-seq (DaPars) to define both the 3'UTR APA profile in esophageal squamous cell carcinoma (ESCC) and to identify 3'UTR shortening events that may drive tumor progression. In four distinct squamous cell carcinoma datasets, BID 3'UTRs were recurrently shortened and BID mRNA levels were significantly upregulated. Moreover, system correlation analysis revealed that CstF64 is a candidate upstream regulator of BID 3'UTR length. Mechanistically, a shortened BID 3'UTR promoted proliferation of ESCC cells by disrupting competing endogenous RNA (ceRNA) cross-talk, resulting in downregulation of the tumor suppressor gene ZFP36L2. These in vitro and in vivo results were supported by human patient data whereby 3'UTR shortening of BID and low expression of ZFP36L2 are prognostic factors of survival in ESCC. Collectively, these findings demonstrate that a key ceRNA network is disrupted through APA and promotes ESCC tumor progression.Significance: High-throughput analysis of alternative polyadenylation in esophageal squamous cell carcinoma identifies recurrent shortening of the BID 3'UTR as a driver of disease progression.

15.
Zhongguo Zhen Jiu ; 41(10): 1171-4, 2021 Oct 12.
Artigo em Chinês | MEDLINE | ID: mdl-34628753

RESUMO

Through analyzing the indication distribution of the different acupoints located at the upper limbs recorded in Science of Acupoints and Science of Meridians and Acupoints, the industry planning teaching materials of traditional Chinese medicine, it is discovered that the acupoints located at the upper arms are commonly selected for the treatment of scrofula and goiter, while the acupoints below the elbow at the hand meridians and those at the lower limbs of the foot meridians which running through the neck, do not have the similar indications. Based on a further analysis on the literature at ancient and modern times, it is believed that the acupoints located on the lateral side of the upper arms, especially those at the large intestine meridian of hand-yangming perhaps have the specific effect in treatment of scrofula and goiter.


Assuntos
Bócio , Meridianos , Tuberculose dos Linfonodos , Pontos de Acupuntura , Braço , Humanos
16.
Am J Transl Res ; 13(9): 10493-10500, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34650719

RESUMO

OBJECTIVE: The combined effects of Orem Self-care Theory and PDCA nursing on cognitive function, neurological function and daily living ability of patients with acute stroke were analyzed in this research. METHODS: 126 patients, who admitted to our hospital with acute stroke from January 2019 to March 2020, were enrolled in this study as research subjects. The subjects were divided into control-group (n=61) and observation-group (n=65) in accordance with their admission time. The control-group received routine nursing care; and the observation-group, was applied with the combined nursing interventions of Orem's self-care mode and PDCA nursing management in addition to conventional treatment. Subsequently, the changes in daily living ability (ADL score), neurological function (GCS score, NIHSS score) and cognitive function (MoCA and MMSE scores) of the two groups before and after receiving nursing care were compared accordingly. RESULTS: After the implementation of nursing measures, the ADL scores of the two groups improved dramatically than before (P<0.05), and observation-group had obviously higher post-intervention scores than that of the control-group (P<0.05); The GCS scores of the two groups were remarkably higher than those before nursing (P<0.05), and the observation-group had critically higher post-intervention scores than those of the control-group (P<0.05); The NIHSS scores of the two groups decreased substantially than before (P<0.05), and the observation-group had dramatically lower scores than the control-group (P<0.05); The MMSE score in two groups increased remarkably than before nursing (P<0.05), and the post-intervention score of observation-group was significantly higher than that of control-group (P<0.05). CONCLUSION: On the basis of Orem Self-care theory, the application of PDCA nursing in daily nursing work to acute stroke patients can actively improve their cognitive function, neurological function and daily life ability. This has a positive role in promoting medical staff to improve the quality of care and provide patients with more comprehensive and thoughtful nursing services.

17.
Shanghai Kou Qiang Yi Xue ; 30(4): 406-409, 2021 Aug.
Artigo em Chinês | MEDLINE | ID: mdl-34693435

RESUMO

PURPOSE: To investigate the current status of oral health cognition behavior and oral health status of children, and to provide countermeasures for the prevention and treatment of oral diseases in children. METHODS: A total of 387 primary school students in the urban area of Shanghai from December 2018 to February 2019 were surveyed using Children's Oral Health Questionnaire and child oral health impact profile(COHIP). SPSS 24.0 software package was used to conduct statistical analysis of the results through descriptive, univariate and multivariate analysis. RESULTS: The cognition of oral health of children aged 6-9 years old in Shanghai urban area was generally good, but their oral health behavior was average. The caries rate of 387 children reached 57.4%, and the oral health status was not good. Correlation analysis and regression analysis showed that children's oral health behavior was positively correlated with oral health cognition(r=0.260,P<0.05), and negatively correlated with positive and negative effects of oral health status(r=-0.333,-0.181,P<0.05), while children's oral health cognition had no significant effect on their oral health status(P>0.05). CONCLUSIONS: The better the oral health behavior habits of children, the greater the positive impact on oral health status; the development of oral health education for children requires more attention to the cultivation of oral health behavior patterns.


Assuntos
Cárie Dentária , Saúde Bucal , Criança , China/epidemiologia , Cognição , Cárie Dentária/epidemiologia , Comportamentos Relacionados com a Saúde , Educação em Saúde Bucal , Humanos
18.
Huan Jing Ke Xue ; 42(11): 5519-5525, 2021 Nov 08.
Artigo em Chinês | MEDLINE | ID: mdl-34708991

RESUMO

The levels of six toxic metals and five essential metals in five groups of vegetables marketed in the eastern coastal region of China were analyzed using inductively coupled plasma mass spectrometry. The results showed that the concentrations of six toxic heavy metals in all the vegetables did not exceed the maximum residue limits. The health risk assessment indicated that consumption of vegetables may not pose a potential noncarcinogenic risk to consumers, while there is a carcinogenic risk level of 10-5 level from inorganic arsenic exposure through vegetable consumption. Additionally, a similar trend was observed for the accumulation of toxic and essential metals. Furthermore, compared with other vegetable groups, edible fungi have a high potential to accumulate toxic and essential metals, which indicates that pollution monitoring of edible fungi should be strengthened.


Assuntos
Metais Pesados , Poluentes do Solo , China , Exposição Dietética , Monitoramento Ambiental , Metais Pesados/análise , Medição de Risco , Poluentes do Solo/análise , Verduras
19.
Clin Case Rep ; 9(9): e04783, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-34512985

RESUMO

Abnormal eosinophils with immature eosinophilic granules are typically observed in acute myeloid leukemia with inv (16) (p13.1q22) or t (16;16) (p13.1;q22) but can also be seen in chronic myeloid leukemia without inv (16) or t (16;16).

20.
Chem Commun (Camb) ; 57(74): 9398-9401, 2021 Sep 16.
Artigo em Inglês | MEDLINE | ID: mdl-34528964

RESUMO

A tumor cell membrane-camouflaged therapeutic system was fabricated to eliminate tumors by embedding apyrase and glucose oxidase (GOx) into zeolitic imidazolate framework-8 (ZIF-8) nanoparticles for tumor-targeted metabolic therapy. Experimental results demonstrated that these functional nanoparticles could disturb the energy supply of tumor cells by depleting ATP and glucose and efficiently induce tumor cell death.


Assuntos
Apirase/metabolismo , Materiais Biomiméticos/metabolismo , Glucose Oxidase/metabolismo , Estruturas Metalorgânicas/metabolismo , Nanopartículas/metabolismo , Neoplasias/metabolismo , Trifosfato de Adenosina/metabolismo , Materiais Biomiméticos/química , Morte Celular/efeitos dos fármacos , Glucose/metabolismo , Humanos , Estruturas Metalorgânicas/química , Estruturas Metalorgânicas/farmacologia , Nanopartículas/química , Neoplasias/tratamento farmacológico , Neoplasias/patologia
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