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1.
PLoS One ; 16(11): e0258204, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34735466

RESUMO

Indoleamine 2,3-dioxygenase 1 (IDO-1) is an immunosuppressive enzyme expressed in the placenta, neoplastic cells, and macrophages to reject T cells by converting tryptophan into kynurenine. However, the role of IDO-1 in brain immunity, especially in the meninges, is unclear. We aim to elucidate the distribution pattern of IDO-1+ macrophages/microglia in the human brain tissues, human glioblastoma, APP/PS1 mouse brains, and quinolinic acid model brains and explore the physiological and immunological roles of IDO-1+ macrophages/microglia. Here, we find that both human and mouse macrophages/microglia of the perivascular and subarachnoid space and in glioblastoma (GBM) expressed IDO-1 but not macrophages/microglia of parenchyma. Using IDO-1 inhibitors including 1-MT and INCB24360, we observed that inhibiting IDO-1 reduced the cellular size and filopodia growth, fluid uptake, and the macropinocytic and phagocytic abilities of human blood monocytes and RAW264.7/BV-2 cells. Inhibiting IDO-1 with 1-MT or INCB24360 increased IL-1ß secretion and suppressed NLRP3 expression in RAW264.7/BV-2 cells. Our data collectively show that IDO-1 expression in perivascular and meninges macrophages/microglia increases cellular phagocytic capacity and might suppress overactivation of inflammatory reaction.

2.
Mol Cell Biochem ; 2021 Nov 26.
Artigo em Inglês | MEDLINE | ID: mdl-34826027

RESUMO

The aim of this study was to investigate the functions and molecular mechanism of miR-196a in esophageal cancer (EC). miR-196a as well as UHRF2 and TET2 mRNA and protein levels in EC tissues and cells were detected using quantitative real-time PCR or western blot, respectively. Cell proliferation was evaluated via MTT assay. Transwell assays were used to detect cell migration. In addition, the targeted relationship between miR-196a and UHRF2 was assessed through a dual luciferase reporter assay. Enzyme-linked immunosorbent assay was performed to detect the levels of the cytosine intermediates 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC). We found increased miR-196a expression in EC tissues and cells but decreased UHRF2 and TET2 expression. Next, functional experiments showed that knockdown of miR-196a or UHRF2 overexpression suppress EC cell proliferation and migration. miR-196a negatively regulates TET2 expression by directly targeting UHRF2. UHRF2 overexpression decreased 5mC levels but increased 5hmC levels. Furthermore, TET2 downregulation reversed the functions of miR-196a inhibition on EC cell proliferation and migration. Collectively, our study suggested that miR-196a was closely related to the progression of EC possibly by regulating the UHRF2/TET2 axis. Thus, miR-196a represents a potential new EC therapeutic target.

3.
Nat Nanotechnol ; 2021 Nov 11.
Artigo em Inglês | MEDLINE | ID: mdl-34764453

RESUMO

Silicone-rubber baby teats used to bottle-feed infants are frequently disinfected by moist heating. However, infant exposure to small microplastics (<10 µm) potentially released from the heated teats by hydrothermal decomposition has not been studied, owing to the limitations of conventional spectroscopy in visualizing microplastic formation and in characterizing the particles at the submicrometre scale. Here both the surfaces of silicone teats subjected to steam disinfection and the wash waters of the steamed teats were analysed using optical-photothermal infrared microspectroscopy. This new technique revealed submicrometre-resolved steam etching on and chemical modification of the teat surface. Numerous flake- or oil-film-shaped micro(nano)plastics (MNPs) (in the size range of 0.6-332 µm) presented in the wash waters, including cyclic and branched polysiloxanes or polyimides, which were generated by the steam-induced degradation of the base polydimethylsiloxane elastomer and the polyamide resin additive. The results indicated that by the age of one year, a baby could ingest >0.66 million elastomer-derived micro-sized plastics (MPs) (roughly 81% in 1.5-10 µm). Global MP emission from teat disinfection may be as high as 5.2 × 1013 particles per year. Our findings highlight an entry route for surface-active silicone-rubber-derived MNPs into both the human body and the environment. The health and environmental risks of the particles are as yet unknown.

4.
Front Plant Sci ; 12: 722459, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34721454

RESUMO

The efficient utilization of irrigation water and nitrogen is of great importance for sustainable agricultural production. Alternate partial root-zone drip irrigation (APRD) is an innovative water-saving drip irrigation technology. However, the coupling effects of water and nitrogen (N) supply under APRD on crop growth, water and N use efficiency, as well as the utilization and fate of residual nitrates accumulated in the soil profile are not clear. A simulated soil column experiment where 30-40 cm soil layer was 15NO3-labeled as residual nitrate was conducted to investigate the coupling effects of different water [sufficient irrigation (W1), two-thirds of the W1(W2)] and N [high level (N1), 50% of N1 (N2)] supplies under different irrigation modes [conventional irrigation (C), APRD (A)] on tomato growth, irrigation water (IWUE) and N use efficiencies (NUE), and the fate of residual N. The results showed that, compared with CW1N1, AW1N1 promoted root growth and nitrogen absorption, and increased tomato yield, while the N absorption and yield did not vary significantly in AW2N1. The N absorption in AW2N2 decreased by 16.1%, while the tomato yield decreased by only 8.8% compared with CW1N1. The highest IWUE appeared in AW2N1, whereas the highest NUE was observed in AW2N2, with no significant difference in NUE between AW2N1 and CW1N1 at the same N supply level. The 15N accumulation peak layer was almost the same as the originally labeled layer under APRD, whereas it moved 10-20 cm downwards under CW1N1. The amount of 15N accumulated in the 0-40 cm layer increased with the decreasing irrigation water and nitrogen supply, with an increase of 82.9-141.1% in APRD compared with that in CW1N1. The utilization of the 15N labeled soil profile by the tomato plants increased by 9-20.5%, whereas the loss rate of 15N from the plant-soil column system decreased by 21.3-50.1% in APRD compared with the CW1N1 treatment. Thus, APRD has great potential in saving irrigation water, facilitating water use while reducing the loss of residual nitrate accumulated in the soil profile, but has no significant effect on the NUE absorbed.

5.
Arch Insect Biochem Physiol ; 108(4): e21846, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-34632624

RESUMO

Gomphocerus sibiricus L., the dominant insect species in the alpine and subalpine grassland, overwinters with diapause at egg stage. In this study, cold tolerance and related cryoprotectants of G. sibiricus eggs were investigated. In particular, the supercooling point (SCP), water content, carbohydrates (trehalose, glucose, fructose, glycogen), polyols (glycerol, inositol, sorbitol), fat, and amino acids contents were evaluated at different developmental stages of G. sibiricus eggs collected under natural conditions. The SCPs of eggs were very low (-32.83 to -22.61°C) at mid-diapause. Water content gradually increased during development. The fructose, glycerol, and sorbitol contents were significantly higher in diapausing eggs than in early embryogenesis stage and post-diapause development stage. Glycogen content was high throughout the whole developmental period. The trehalose, glucose, and inositol contents were low during diapause compared to that in early embryogenesis stage and post-diapause development stage. There were no significant differences in the fat content of eggs among all development stages. The total amino acid contents in eggs in the early embryogenesis and at the start of diapause were higher than that in post-diapause eggs. The contents of Glu, Asp, Leu, Pro and Arg during diapause were significantly higher than those during post-diapause development. Results indicate that G. sibiricus eggs have a high supercooling capacity. Successful overwintering can be attributed to the accumulation of glycerol, fructose, sorbitol, and amino acids (Glu, Asp, Leu, Pro and Arg). These findings provide insight into the mechanisms underlying the adaptation of G. sibiricus to cold conditions.


Assuntos
Aclimatação/fisiologia , Temperatura Baixa , Diapausa de Inseto/fisiologia , Gafanhotos/fisiologia , Aminoácidos/análise , Aminoácidos/metabolismo , Animais , Metabolismo dos Carboidratos , Carboidratos/análise , Crioprotetores , Gafanhotos/metabolismo , Larva/metabolismo , Larva/fisiologia
6.
Sheng Wu Gong Cheng Xue Bao ; 37(10): 3401-3404, 2021 Oct 25.
Artigo em Chinês | MEDLINE | ID: mdl-34708598

RESUMO

Humanity shares the common interest to protect the environment and to maintain a healthy global ecosystem. International collaboration is key in this context, to advance the necessary science and technology. The National Science Foundation of China (NSFC) and European Commission (EC) have agreed to collaborate in innovative knowledge and technology in the field of bioremediation of polluted environments and biodegradation of plastics. In this context, projects on bioremediation of soils, wastewater and sediment matrices and on microbial degradation of plastics were supported. This special issue aimed to introduce these projects and their progresses in the related fields. In total, 23 papers have been collected in this issue, covering both fundamental and applied researches.


Assuntos
Ecossistema , Plásticos , Biodegradação Ambiental , China
7.
Sheng Wu Gong Cheng Xue Bao ; 37(10): 3459-3474, 2021 Oct 25.
Artigo em Chinês | MEDLINE | ID: mdl-34708604

RESUMO

Sulfonamides (SAs) are a kind of antibiotics widely used in medical treatment and livestock breeding. However, they have poor degradability in human and animal intestines, and will enter the sewage treatment system through the discharge of feces and urine. The aerobic activated sludge (AAS) in wastewater treatment plant was found to be able to effectively transform SAs. This article summarizes the advances in biodegradation of SAs in aerobic activated sludge system, which includes the biodegradation mechanisms, the main biodegradation pathways, and the environmental factors affecting the degradation efficiency. Challenges encountered in the current research were discussed, with the aim to provide scientific basis for optimizing the biodegradation of SAs in wastewater treatment process.


Assuntos
Esgotos , Poluentes Químicos da Água , Antibacterianos , Biodegradação Ambiental , Humanos , Sulfonamidas , Poluentes Químicos da Água/análise
8.
Sheng Wu Gong Cheng Xue Bao ; 37(10): 3475-3486, 2021 Oct 25.
Artigo em Chinês | MEDLINE | ID: mdl-34708605

RESUMO

A plethora of organic pollutants such as pesticides, polycyclic and halogenated aromatic hydrocarbons, and emerging pollutants, such as flame retardants, is continuously being released into the environment. This poses a huge threat to the society in terms of environmental pollution, agricultural product quality, and general safety. Therefore, effective removal of organic pollutants from the environment has become an important challenge to be addressed. As a consequence of the recent and rapid developments in additive manufacturing, 3D bioprinting technology is playing an important role in the pharmaceutical industry. At the same time, an increasing number of microorganisms suitable for the production of biomaterials with complex structures and functions using 3D bioprinting technology, have been identified. This article briefly discusses the principles, advantages, and disadvantages of different 3D bioprinting technologies for pollutant removal. Furthermore, the feasibility and challenges of developing bioremediation technologies based on 3D bioprinting have also been discussed.


Assuntos
Bioimpressão , Poluentes Ambientais , Materiais Biocompatíveis , Biodegradação Ambiental , Tecnologia , Engenharia Tecidual
9.
Sheng Wu Gong Cheng Xue Bao ; 37(10): 3487-3504, 2021 Oct 25.
Artigo em Chinês | MEDLINE | ID: mdl-34708606

RESUMO

Antibiotics are widely used and prevalently distributed in the environment. The issue of antibiotic resistance genes has posed a huge threat to the global public health. Soil is an important sink of antibiotics in the environment. Antibiotic exposure may introduce adverse effects on soil organisms, and bring indirect but potential risks to human health. Therefore, it is urgent to take actions to remediate antibiotics-contaminated soil. This review summarized effects of antibiotics on phenotype growth of plants, physiological characteristics and community structure of animals, composition and structure of microbial communities, and transmission of antibiotic resistance genes among organisms in soil. Additionally, the potential and prospects of employing antibiotic-resistant soil plants, animals, microorganisms, and their combinations to treat antibiotics-contaminated soil were illustrated. Last but not least, the unaddressed issues in this area were proposed, which may provide insights into relevant research directions in the future.


Assuntos
Poluentes do Solo , Solo , Animais , Antibacterianos/farmacologia , Biodegradação Ambiental , Resistência Microbiana a Medicamentos/genética , Humanos , Microbiologia do Solo
10.
Sci Total Environ ; : 151032, 2021 Oct 22.
Artigo em Inglês | MEDLINE | ID: mdl-34695462

RESUMO

Although yellow Cd pigments (Cd-YP), widely used in industrial colorants, are considered inert, increasing evidence suggests once released into the environment, photobleaching/weathering mobilizes Cd from these pigments posing a pollution threat. Although general redox conditions and biotic/microbial activity are known to be important factors in determining Cd release, how spatial trends and specific soil processes regulate the Cd-YP behavior are poorly understood. Using plant rhizotrons in controlled environmental conditions, this study investigated the behavior of Cd-YP amendments matched to levels (15 mg kg-1) representative of contaminated soils in Yixing, China. Using high-resolution two-dimensional diffusive-gradient-in-thin-films (HR-2D-DGT), planar-optode (PO) multilayer systems alongside targeted soil and porewater sampling for chemical analysis the biogeochemistry associated with Cd mobilization from Cd-YP rice rhizospheres were determined. The results showed that there was a significant release of Cd into soil porewaters (51.5 µg L-1), but this reduced by 90.9% and stabilized over time (after 6-days). HR-2D-DGT ion-maps revealed pronounced spatial variances. The flux-maxima for Cd, which located within aerobic-rhizosphere zones, was 9 to 19-fold higher than in associated anoxic bulk soil. In general, zones of radial O2 loss (ROL)/higher redox conditions and lower pH were associated with Cd release, with S2- to SO42- transitions marking the boundaries of high-flux areas. Some isolated colocalization of Fe and Cd hotspots were observed in lateral root regions, but on-the-whole Fe/Mn and Cd release were not linked. In addition, microniche development was also an important feature of Cd mobilization due to soil heterogeneity.

11.
Front Bioeng Biotechnol ; 9: 720315, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34485259

RESUMO

High containment biological laboratories (HCBL) are required for work on Risk Group 3 and 4 agents across the spectrum of basic, applied, and translational research. These laboratories include biosafety level (BSL)-3, BSL-4, animal BSL (ABSL)-3, BSL-3-Ag (agriculture livestock), and ABSL-4 laboratories. While SARS-CoV-2 is classified as a Risk Group 3 biological agent, routine diagnostic can be handled at BSL-2. Scenarios involving virus culture, potential exposure to aerosols, divergent high transmissible variants, and zoonosis from laboratory animals require higher BSL-3 measures. Establishing HCBLs especially those at BSL-4 is costly and needs continual investments of resources and funding to sustain labor, equipment, infrastructure, certifications, and operational needs. There are now over 50 BSL-4 laboratories and numerous BSL-3 laboratories worldwide. Besides technical and funding challenges, there are biosecurity and dual-use risks, and local community issues to contend with in order to sustain operations. Here, we describe case histories for distinct HCBLs: representative national centers for diagnostic and reference, nonprofit organizations. Case histories describe capabilities and assess activities during COVID-19 and include capacities, gaps, successes, and summary of lessons learned for future practice.

12.
Artigo em Inglês | MEDLINE | ID: mdl-34538568

RESUMO

BACKGROUND/PURPOSE: Mass screening for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is important to prevent the spread of coronavirus disease 2019 (COVID-19). Pooling samples can increase the number of tests processed. LabTurbo AIO 48 is an automated platform that allows ribonucleic acid extraction and sample analysis on the same instrument. We created a novel pooling assay on this platform for SARS-CoV-2 detection and demonstrated that the pooling strategy increases testing capacity without affecting accuracy and sensitivity. METHODS: Comparative limit of detection (LoD) assessment was performed on the LabTurbo AIO 48 platform and the current standard detection system based on real-time reverse transcription polymerase chain reaction (rRT-PCR) using 55 clinically positive samples. An additional 330 primary clinical samples were assessed. RESULTS: Six samples pooled into one reaction tube were detected in approximately 2.5 h using the World Health Organization rRT-PCR protocol. LabTurbo AIO 48 also demonstrated a higher throughput than our reference rRT-PCR assay, with an LoD of 1000 copies/mL. The overall percentage agreement between the methods for the 330 samples was 100%. CONCLUSION: We created a novel multi-specimen pooling assay using LabTurbo AIO 48 for the robust detection of SARS-CoV-2, allowing high-throughput results; this assay will aid in better control and prevention of COVID-19. The diagnostic assay was cost-effective and time-efficient; thus, the pooling strategy is a practical and effective method for diagnosing large quantities of specimens without compromising precision.

13.
ACS Nano ; 15(10): 16344-16356, 2021 10 26.
Artigo em Inglês | MEDLINE | ID: mdl-34569785

RESUMO

Fully understanding the environmental implications of engineered nanomaterials is crucial for their safe and sustainable use. Cyanobacteria, as the pioneers of the planet earth, play important roles in global carbon and nitrogen cycling. Here, we evaluated the biological effects of molybdenum disulfide (MoS2) nanosheets on a N2-fixation cyanobacteria (Nostoc sphaeroides) by monitoring growth and metabolome changes. MoS2 nanosheets did not exert overt toxicity to Nostoc at the tested doses (0.1 and 1 mg/L). On the contrary, the intrinsic enzyme-like activities and semiconducting properties of MoS2 nanosheets promoted the metabolic processes of Nostoc, including enhancing CO2-fixation-related Calvin cycle metabolic pathway. Meanwhile, MoS2 boosted the production of a range of biochemicals, including sugars, fatty acids, amino acids, and other valuable end products. The altered carbon metabolism subsequently drove proportional changes in nitrogen metabolism in Nostoc. These intracellular metabolic changes could potentially alter global C and N cycles. The findings of this study shed light on the nature and underlying mechanisms of bio-nanoparticle interactions, and offer the prospect of utilization bio-nanomaterials for efficient CO2 sequestration and sustainable biochemical production.


Assuntos
Molibdênio , Nostoc , Carbono , Nitrogênio
14.
World J Pediatr ; 17(5): 517-526, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34468958

RESUMO

BACKGROUND: Vitamin E is the most abundant lipid-soluble antioxidants present in plasma; however, the relationship between serum vitamin E and change in body mass index (BMI)-for-age Z scores in adolescents has not been well described. METHODS: This study is a cross-sectional study. Data were analyzed from 4014 adolescents who participated in the National Health and Nutrition Examination Survey. The nutritional status was calculated by BMI Z scores and was classified into normal weight, overweight, and obese. Multivariable-adjusted logistic regression was used to examine the association between serum vitamin E levels with overweight/obesity. Besides, the interaction effects between potential confounders and vitamin E on obesity were further evaluated. RESULTS: After adjusting potential confounders, serum vitamin E levels were negatively associated with overweight/obesity in girls but not in boys. Per standard deviation increment in vitamin E concentrations was associated with a 92% decreased risk of obesity in females. Besides, lower quartiles of serum vitamin E were associated with a higher risk of overweight/obesity in girls. Moreover, the inverse association between serum vitamin E levels and obesity was also found in most subgroups through subgroup analysis. CONCLUSIONS: Our study supports the negative association between serum vitamin E levels and overweight/obesity in adolescents. A higher serum vitamin E level may be associated with a reduced probability of obesity in girls, but not in boys.

15.
PeerJ ; 9: e11991, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34557346

RESUMO

Background: There is a global pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Information on viral genomics is crucial for understanding global dispersion and for providing insight into viral pathogenicity and transmission. Here, we characterized the SARS-CoV-2 genomes isolated from five travelers who returned to Taiwan from the United States of America (USA) between March and April 2020. Methods: Haplotype network analysis was performed using genome-wide single-nucleotide variations to trace potential infection routes. To determine the genetic variations and evolutionary trajectory of the isolates, the genomes of isolates were compared to those of global virus strains from GISAID. Pharyngeal specimens were confirmed to be SARS-CoV-2-positive by RT-PCR. Direct whole-genome sequencing was performed, and viral assemblies were subsequently uploaded to GISAID. Comparative genome sequence and single-nucleotide variation analyses were performed. Results: The D614G mutation was identified in imported cases, which separated into two clusters related to viruses originally detected in the USA. Our findings highlight the risk of spreading SARS-CoV-2 variants through air travel and the need for continued genomic tracing for the epidemiological investigation and surveillance of SARS-CoV-2 using viral genomic data. Conclusions: Continuous genomic surveillance is warranted to trace virus circulation and evolution in different global settings during future outbreaks.

16.
Environ Pollut ; 289: 117880, 2021 Nov 15.
Artigo em Inglês | MEDLINE | ID: mdl-34352632

RESUMO

Nitrated nonylphenols (NNPs) are main metabolites of the endocrine-disrupting nonylphenols in soil, yet their fate is unknown. Here, using four NNP isomers (NNP111, NNP112, NNP65, and NNP38), the degradation pattern of NNPs was investigated in an oxic soil for 266 days. Specifically, NNP111 was 14C-labeled to facilitate investigating its degradation, transformation, and non-extractable residue (NER) formation. NNPs degradation was isomer-specific with the decreasing order of half-life: NNP111 (126 days) > NNP112 (76 days) > NNP65 (14 days) > NNP38 (8.4 days), providing direct evidence of the greater persistence of NNPs in soil than their parent NPs. At the end of the incubation, 8.5 %, 7.3 %, and 39.9 % of 14C-NNP111 was mineralized, transformed to 2-amino-NP111, and formed NERs in active soil, respectively. In contrast, NERs in sterilized soils were significantly lower, amounting to 15.1 % and 17.3 % in autoclaved and γ-irradiated soil, respectively. The majority of the NERs (>70 %) were in humin fraction, in which type I NER was the predominant (>90 %) mode for NER formation. Our results provide comprehensive knowledge on the fate of NNPs in soil, demonstrating that isomer-specific behavior, transformation products of NNPs, and NER formation should be considered when evaluating environmental fate and risks of NNPs.


Assuntos
Poluentes do Solo , Solo , Nitratos , Fenóis/análise , Microbiologia do Solo , Poluentes do Solo/análise
17.
Infect Drug Resist ; 14: 3255-3261, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34429623

RESUMO

Purpose: Accurate molecular diagnostic assays for detecting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, are needed for epidemiology studies and to support infection-control measures. We evaluated the analytical sensitivity and clinical performance of three sample-to-answer molecular-diagnostics systems for detecting SARS-CoV-2 using 325 nasopharyngeal swab clinical samples from symptomatic patients. Methods: The BioFire Respiratory Panel 2.1 (RP2.1), cobas Liat SARS-CoV-2 and Influenza A/B, and Cepheid Xpert Xpress SARS-CoV-2/Flu/RSV platforms, which have been granted emergency-use authorization by the US FDA, were tested and compared. Results: The positive percent agreement, negative percent agreement, and overall percent agreement among the three point of care testing systems were 98-100%, including for the wild-type SARS-CoV-2 (non-B.1.1.7) and a variant of concern (B.1.1.7). Notably, the BioFire RP2.1 may fail to detect the SARS-CoV-2 S gene in the B.1.1.7 lineage because of the spike protein mutation. Conclusion: All three point of care testing platforms provided highly sensitive, robust, and almost accurate results for rapidly detecting SARS-CoV-2. These automated molecular diagnostic assays can increase the effectiveness of control and prevention measures for infectious diseases.

18.
Environ Pollut ; 288: 117737, 2021 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-34246999

RESUMO

2,2',4,4'-tetrabromodiphenyl ether (BDE-47) was difficult to degrade in sediments. In this study, the environmental behavior of BDE-47 with/without the effect of benthos (Tubificidae Limnodrilus) and electron acceptors in sediments was investigated using C-14 tracer. Generally, extractable residues of BDE-47 were dominant in sediment and posed high environment risk. The amount of non-extractable residues (NERs) accounted for 39.0% of initial radioactivity in oxic sediments was significantly higher than those in anoxic sediments (17.6%). Most of NERs were localized in the humin fraction and presented as sequestrated forms. Under oxic conditions, the present of Limnodrilus significantly increased the proportion of NERs in sediment. Limnodrilus accumulated 34.2% of initial radioactivity. Under anoxic conditions, the addition of iron (Ⅲ) [Fe(III)], sulfate and nitrate reduced the environmental risk of BDE-47 with the increase of NERs formation, while manganese (IV) [Mn(IV)] addition had no effect on the formation of NERs. The present of Limnodrilus and electron acceptors promoted the production of metabolites. Meanwhile, BDE-47 changed the microbial community structure of sediments. These findings indicated that the environmental behavior and risk of BDE-47 was affected by benthos and electron acceptors, and the high proportion of sequestrated NERs posed high bioactivity and toxic threat to ecological environment.


Assuntos
Compostos Férricos , Oligoquetos , Animais , Elétrons , Sedimentos Geológicos , Éteres Difenil Halogenados
19.
Neuropsychiatr Dis Treat ; 17: 1839-1857, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34135586

RESUMO

Objective: This study aimed to explore the correlation between white matter hyperintensity (WMH) and post-stroke depression (PSD) at 3 months, and to further investigate sex differences in the pathogenesis of PSD. Methods: A total of 238 consecutive patients with acute cerebral infarction were recruited. PSD was assessed at 2 weeks and at 3 months after stroke onset. All stroke cases were divided into four subgroups according to the diagnosis of depression at two time nodes: continuous depression; depression remission; late-onset PSD; and continuous non-depression. The Fazekas and Scheltens visual rating scales were adopted to assess WMH. Results: Logistic regression revealed that the presence of periventricular white matter hyperintensity (PVWMH) at baseline in male patients was an independent risk factor for PSD at 3 months. Further subgroup analysis revealed that PVWMH was associated with late-onset PSD in males, but not with continuous depression 3 months after stroke. Male acute stroke patients with PVWMH at baseline were more likely to develop PSD at 3 months, especially late-onset PSD. Conclusion: Our data suggest that sex differences may influence the pathogenesis of PSD.

20.
BMC Geriatr ; 21(1): 355, 2021 06 10.
Artigo em Inglês | MEDLINE | ID: mdl-34112103

RESUMO

BACKGROUND: Since the outbreak of COVID-19, it has been documented that old age and underlying illnesses are associated with poor prognosis among COVID-19 patients. However, it is unknown whether sarcopenia, a common geriatric syndrome, is associated with poor prognosis among older COVID-19 patients. The aim of our prospective cohort study is to investigate the association between sarcopenia risk and severe disease among COVID-19 patients aged ≥60 years. METHOD: A prospective cohort study of 114 hospitalized older patients (≥60 years) with confirmed COVID-19 pneumonia between 7 February, 2020 and 6 April, 2020. Epidemiological, socio-demographic, clinical and laboratory data on admission and outcome data were extracted from electronic medical records. All patients were assessed for sarcopenia on admission using the SARC-F scale and the outcome was the development of the severe disease within 60 days. We used the Cox proportional hazards model to identify the association between sarcopenia and progression of disease defined as severe cases in a total of 2908 person-days. RESULT: Of 114 patients (mean age 69.52 ± 7.25 years, 50% woman), 38 (33%) had a high risk of sarcopenia while 76 (67%) did not. We found that 43 (38%) patients progressed to severe cases. COVID-19 patients with higher risk sarcopenia were more likely to develop severe disease than those without (68% versus 22%, p < 0.001). After adjustment for demographic and clinical factors, higher risk sarcopenia was associated with a higher hazard of severe condition [hazard ratio = 2.87 (95% CI, 1.33-6.16)]. CONCLUSION: We found that COVID-19 patients with higher sarcopenia risk were more likely to develop severe condition. A clinician-friendly assessment of sarcopenia could help in early warning of older patients at high-risk with severe COVID-19 pneumonia.


Assuntos
COVID-19 , Sarcopenia , Idoso , Feminino , Avaliação Geriátrica , Humanos , Modelos de Riscos Proporcionais , Estudos Prospectivos , SARS-CoV-2 , Sarcopenia/diagnóstico , Sarcopenia/epidemiologia , Inquéritos e Questionários
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