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Biomed Environ Sci ; 29(9): 686-689, 2016 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-27806752


Rats were exposed to 1 or 10 µg/mL bisphenol A (BPA) in water during pregnancy and lactation. Offspring rats were given normal water and a standard diet from weaning to postnatal day (PND) 50. Perinatal exposure to BPA resulted in significantly increased body weight, visceral adipose tissue, abnormal serum lipids, and lower adiponectin (ADP) levels in both female and male offspring rats. Liver adipose triglyceride lipase (Atgl) mRNA levels and ADP protein in visceral adipose tissue were significantly decreased in BPA-exposed offspring rats. In both female or male offspring rats, obesity and dyslipidemia induced by perinatal exposure to BPA were associated with down regulation of Atgl mRNA in liver and ADP protein in visceral adipose tissue.

Compostos Benzidrílicos/efeitos adversos , Dislipidemias/metabolismo , Lipase/metabolismo , Lipídeos/sangue , Obesidade/metabolismo , Fenóis/efeitos adversos , Efeitos Tardios da Exposição Pré-Natal/metabolismo , Adiponectina/metabolismo , Tecido Adiposo/metabolismo , Animais , Compostos Benzidrílicos/metabolismo , Peso Corporal , Dislipidemias/enzimologia , Dislipidemias/etiologia , Dislipidemias/fisiopatologia , Feminino , Humanos , Lipase/genética , Masculino , Obesidade/enzimologia , Obesidade/etiologia , Obesidade/fisiopatologia , Fenóis/metabolismo , Gravidez , Efeitos Tardios da Exposição Pré-Natal/enzimologia , Efeitos Tardios da Exposição Pré-Natal/etiologia , Efeitos Tardios da Exposição Pré-Natal/fisiopatologia , Ratos , Ratos Sprague-Dawley
Ann Nutr Metab ; 60(4): 293-7, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-22678104


BACKGROUND/AIMS: Supplementation with antioxidants is of special interest in preventing or delaying the development and progression of age-related macular degeneration (AMD). This investigation aimed to assess the effect of α- lipoic acid (LA) on serum lipids, serum malondialdehyde (MDA) and superoxide dismutase (SOD) in patients with AMD. METHODS: A total of 62 patients (50-75 years old) with early and intermediate dry form of AMD were randomly assigned to two groups, i.e. LA administration (n = 32) and placebo (n = 30). The levels of serum lipids and MDA and SOD activity were measured before and after LA and placebo intervention. RESULTS: Compared with the parameters at baseline, serum total cholesterol (CHO), triglyceride and high- and low-density lipoprotein CHO (HDL and LDL) levels were not significantly different after LA and placebo intervention. There was a slight but statistically nonsignificant decrease in serum MDA levels and a statistically significant increase in serum SOD activity after LA intervention. There were no statistically significant differences in serum MDA levels or SOD activity after placebo intervention. CONCLUSION: The apparent increase in SOD activity caused by LA supplementation indicates that LA may have a possible preventive effect in the development of AMD through an antioxidant mechanism.

Antioxidantes/metabolismo , Suplementos Nutricionais , Lipoproteínas LDL/sangue , Degeneração Macular/fisiopatologia , Ácido Tióctico/administração & dosagem , Administração Oral , Idoso , HDL-Colesterol/sangue , LDL-Colesterol/sangue , Feminino , Humanos , Peroxidação de Lipídeos/efeitos dos fármacos , Degeneração Macular/sangue , Masculino , Malondialdeído/sangue , Pessoa de Meia-Idade , Estresse Oxidativo/efeitos dos fármacos , Fatores de Risco , Superóxido Dismutase/sangue , Triglicerídeos/sangue
Biomed Environ Sci ; 24(5): 506-11, 2011 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-22108416


OBJECTIVE: The paper aims to evaluate the risk factors for age-related macular degeneration (AMD) in elderly Chinese population in Shenyang, a northeast city of China. METHODS: A case-control study was conducted to investigate the risk factors for the prevalence of AMD. Ninety three AMD patients diagnosed by a complete ophthalmic examination were recruited as cases from the outpatient departments of two eye hospitals in Shenyang, while 108 normal subjects of similar age and sex were recruited as controls. A questionnaire was administered among both cases and controls. RESULTS: AMD patients aged 60 years and older accounted for 75.3%. There were significantly higher educational levels, shorter smoking history, less sunlight exposure and cataract, and higher proportion of antioxidants intake in controls than in AMD patients. The frequency of intake of fruits, legumes, fish and shrimps was significantly higher in controls than in AMD patients. In a binary logistic regression analysis, smoking and cataract were the risk factors for AMD (OR: 4.44, 95% CI: 2.27-8.69; OR: 4.47, 95% CI: 2.26-8.85 respectively). The high educational background was a protective factor for AMD (OR: 0.761, 95% CI: 0.51-0.98). CONCLUSION: A low educational background, smoking and cataract are associated with a higher prevalence of AMD.

Catarata/complicações , Degeneração Macular/etiologia , Fumar/efeitos adversos , Idoso , Idoso de 80 Anos ou mais , Antioxidantes , Estudos de Casos e Controles , China/epidemiologia , Suplementos Nutricionais/estatística & dados numéricos , Escolaridade , Comportamento Alimentar , Feminino , Humanos , Degeneração Macular/epidemiologia , Masculino , Pessoa de Meia-Idade , Fatores de Risco , Luz Solar/efeitos adversos
Artigo em Chinês | MEDLINE | ID: mdl-14761430


OBJECTIVE: To study the effects of fluoride on the proliferation and differentiation of osteoblasts in sucking rats and the antagonism of vitamin Cin vitro. METHODS: The enzyme digesting method was used to isolate the rat osteoblasts; the proliferative response was determined by the percents of reduced alamarBlue; the activity of alkaline phosphatase (ALP) was measured by ELISA method. RESULTS: The proliferation of sucking rat osteoblasts was increased at 0.10 - 1.00 mmol/L of NaF, whereas inhibited at >or= 2.00 mmol/L. ALP activity was increased at 0.01 - 0.05 mmol/L of NaF, and decreased at >or= 0.10 mmol/L. The inhibition on proliferation and differentiation at 2 mmol/L NaF was antagonized by vitamin C. CONCLUSION: Fluoride had a two-phase effect on osteoblasts, vitamin C could antagonize the inhibitory effect of higher concentration of fluoride on proliferation and differentiation of osteoblasts.

Ácido Ascórbico/farmacologia , Diferenciação Celular/efeitos dos fármacos , Fluoretos/farmacologia , Osteoblastos/efeitos dos fármacos , Fosfatase Alcalina/análise , Animais , Animais Recém-Nascidos , Proliferação de Células/efeitos dos fármacos , Ensaio de Imunoadsorção Enzimática , Osteoblastos/citologia , Osteoblastos/enzimologia , Ratos , Ratos Wistar