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1.
Environ Sci Pollut Res Int ; 24(36): 27788-27798, 2017 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-28983739

RESUMO

NO can be removed at the same time with SO2 by aqueous Co(NH3)62+ solution. The reduction of Co(NH3)63+ to Co(NH3)62+ is catalyzed by activated carbon to regain the NO absorption ability of the scrubbing solution. Oxalic acid solution is explored to change the carbon surface to ameliorate its catalytic capability. The experimental results suggest that the best catalyst is prepared by impregnating the carbon sample in 0.7 mol l-1 oxalic acid solution for 24 h followed by being activated at 600 °C for 5 h under nitrogen atmosphere. After being treated with oxalic acid solution, the surface area and the acidity on the carbon surface increase. The experiments show that the carbon modified with oxalic acid can get a much higher NO removal efficiency than the original carbon.


Assuntos
Carbono/análise , Poluentes Ambientais/química , Recuperação e Remediação Ambiental/métodos , Óxido Nítrico/química , Ácido Oxálico/análise , Catálise , Carvão Vegetal/análise , Cobalto
2.
Zhonghua Yi Xue Za Zhi ; 92(42): 2965-7, 2012 Nov 13.
Artigo em Chinês | MEDLINE | ID: mdl-23328285

RESUMO

OBJECTIVE: To analyze the clinical features, risk factors and drug uses of senior hospitalized patients with chronic constipation. METHODS: A total of 162 hospitalized patients aged 85 years and over at our hospital during the period of January-March 2012 conducted a questionnaire survey. There were 137 males and 25 females. And 112 cases of chronic constipation were diagnosed in accordance with the Rome III criteria. The survey included general condition, risk factors of constipation, spectrum of symptoms, associated symptoms, previous medication and medication for constipation after admission. The results were statistically analyzed by Logistic regression. RESULTS: Their average age was (90 ± 4) years old. And the total prevalence of chronic constipation was 69.1% (112/162). Logistic regression analysis showed that less activity (OR = 10.873) and diet (OR = 4.752) were the important risk factors. Defecation effort was the most common symptom (n = 85, 75.9%). A total of 88 cases (78.6%) took lactulose alone or lactulose plus other laxatives. The reasons of using lactulose were as follows: dietary restrictions (n = 31, 35.2%), aspiration prevention (n = 21, 23.9%) and poor efficacy of other laxatives (n = 36, 40.9%). CONCLUSIONS: Prevalence of constipation is high among senior hospitalized patients. Less activity and diet are the main risk factors. And lactulose should be a first-line therapy.


Assuntos
Constipação Intestinal/diagnóstico , Inquéritos e Questionários , Idoso de 80 Anos ou mais , Dieta , Feminino , Humanos , Pacientes Internados , Lactulose/uso terapêutico , Modelos Logísticos , Masculino , Atividade Motora , Fatores de Risco
3.
Chin Med J (Engl) ; 123(18): 2502-9, 2010 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-21034618

RESUMO

BACKGROUND: Although the migration of hepatic stellate cells (HSCs) is essential for hepatic fibrotic response, the detailed mechanisms involved are poorly understood. The aim of this study was to examine the role of Rho GTPases (especially RhoA) in platelet-derived growth factor (PDGF)-BB-induced migration of HSCs. METHODS: The migration of primary rat HSCs was evaluated using transwell Boyden chamber, while cytoskeletal changes were visualized by immunofluorescence staining of intracellular actins and vinculin. Quantitative real-time PCR and Western blotting analysis were used to detect the expression of Rho GTPases (RhoA, Rac1 and Cdc42) within HSCs and their activation was determined by glutathione S-transferase pull-down assay. Finally, the effects of RhoA on PDGF-BB-induced cell migration and cytoskeletal remodeling were analyzed using HSC-T6 cells stably transfected with constitutively active (CA, Q63L) or dominant negative (DN, T19N) RhoA mutants. Data were analyzed using SPSS 16.0 software. Student's t test was used to analyze differences between two groups and one-way analysis of variance (ANOVA) was used among multiple groups. RESULTS: Rapid cytoskeletal remodeling led to a significant increase in the motility of primary rat HSCs after haptotactic (direct) and chemotactic (indirect) stimulation by PDGF-BB. PDGF-BB caused a dramatic elevation in the levels of both total and active RhoA protein. However, the levels of mRNA for Rho GTPases, including RhoA, Rac1 and Cdc42, were unaffected. Furthermore, PDGF-BB induced increased formation of stress fibers and focal adhesions in HSC-T6 cells transfected with CA-RhoA, but not in HSC-T6 transfected with DN-RhoA. Surprisingly, both CA- and DN-RhoA-transfected HSC-T6 cells showed decreased migratory potential in the absence or presence of PDGF-BB compared with controls. CONCLUSIONS: PDGF-BB induced cytoskeletal remodeling in rat HSCs and promoted their migration via regulation of intracellular RhoA. RhoA may be one of the determinants in PDGF-BB-induced HSC migration.


Assuntos
Movimento Celular/efeitos dos fármacos , Células Estreladas do Fígado/efeitos dos fármacos , Células Estreladas do Fígado/metabolismo , Fator de Crescimento Derivado de Plaquetas/farmacologia , Proteína rhoA de Ligação ao GTP/metabolismo , Animais , Becaplermina , Western Blotting , Linhagem Celular , Movimento Celular/genética , Células Cultivadas , Imunofluorescência , Glutationa Transferase/genética , Glutationa Transferase/metabolismo , Masculino , Reação em Cadeia da Polimerase , Proteínas Proto-Oncogênicas c-sis , Ratos , Ratos Sprague-Dawley , Proteína rhoA de Ligação ao GTP/genética
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