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1.
Mater Horiz ; 8(9): 2494-2502, 2021 Aug 31.
Artigo em Inglês | MEDLINE | ID: mdl-34870307

RESUMO

Supramolecular macrocycle-mediated photoreaction has been a research hotspot recently. Herein, we fabricated a photo-responsive intelligent supramolecular assembly that consisted of a water-soluble dithienylethene derivative (DTE-MPBT) and cucurbit[n]urils (CB[n]). Importantly, CB[n], especially CB[8], could act as activators and trigger conformational alteration of the arm parts (typical molecular rotors) of DTE-MPBT, achieving dual functions, i.e. high-efficiency visible-light-cyclization reaction of the DTE core and fluorescence enhancement of DTE-MPBT, resulting in the formation of a dual visible light-driven fluorescent switch. These unexpected discoveries prompted the supramolecular assembly to be applied to dual-visible-light-controlled targeted lysosomal imaging and QR code information recognition. Moreover, the solid-state assembly exhibited more outstanding fluorescence and visible-light-switched fluorescence performance because of the host-guest-induced aggregation synergistic effect, showing fascinating applications, such as light-manipulative data storage and anti-counterfeiting. In brief, we unprecedentedly adopted a supramolecular strategy of "killing two birds with one stone", i.e. assembly-activated photochromism (AAP) and assembly-activated emission enhancement (AAEE), to fabricate dual-visible-light-driven fluorescent switches, which show promising application prospects in biomimetic smart nanomaterials based on supramolecular self-assembly systems.

2.
Invest Ophthalmol Vis Sci ; 62(15): 9, 2021 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-34882205

RESUMO

Purpose: This retrospective study investigated the patterns and risk factors of progression of myopic traction maculopathy (MTM) of fellow eyes after pars plana vitrectomy (PPV) of primary eyes. Methods: The study population comprised 153 patients with MTM in both myopic eyes who sequentially underwent PPV (2006-2021). Observation periods were from PPV of the primary eye (baseline) to PPV of the fellow (end). MTM was graded based on optical coherence tomography (OCT) images and the ATN (atrophy [A], traction [T], and neovascularization [N]) system. An increase in T grade was considered MTM progression. Results: MTM progressed in 43.8% of fellow eyes during 34.57 ± 34.08 months. The progression of fellow eyes correlated with T grade of primary eyes (P < 0.001). Risk factors for the progression of MTM in fellow eyes were primary eyes in T4-T5, age at baseline <60 years, and fellow eyes with partial posterior vitreous detachment (PVD; P < 0.001, P = 0.042, and P = 0.002, respectively). Fellow eyes in T1/T2 at baseline progressed faster compared with those in T0 (P < 0.001); the annual rate of progression to T3-T5 of the T0 (T1-T2) groups was 9.98% (24.59%). Conclusions: Risk factors for the progression of MTM in fellow eyes included PPV when relatively young, primary eye at high T grade, and partial PVD of the fellow eye. Personalized follow-up for fellow eyes should be based on the severity of MTM of both eyes.

4.
Front Neurol ; 12: 706631, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34858306

RESUMO

Purpose: To investigate the brain information flow pattern in patients with early mild cognitive impairment (EMCI) and explore its potential ability of differentiation and prediction for EMCI. Methods: In this study, 49 patients with EMCI and 40 age- and sex-matched healthy controls (HCs) with available resting-state functional MRI images and neurological measures [including the neuropsychological evaluation and cerebrospinal fluid (CSF) biomarkers] were included from the Alzheimer's Disease Neuroimaging Initiative. Functional MRI measures including preferred information flow direction between brain regions and preferred information flow index of each brain region parcellated by the Atlas of Intrinsic Connectivity of Homotopic Areas (AICHA) were calculated by using non-parametric multiplicative regression-Granger causality analysis (NPMR-GCA). Edge- and node-wise Student's t-test was conducted for between-group comparison. Support vector classification was performed to differentiate EMCI from HC. The least absolute shrinkage and selection operator (lasso) regression were used to evaluate the predictive ability of information flow measures for the neurological state. Results: Compared to HC, disturbed preferred information flow directions between brain regions involving default mode network (DMN), executive control network (ECN), somatomotor network (SMN), and visual network (VN) were observed in patients with EMCI. An altered preferred information flow index in several brain regions (including the thalamus, posterior cingulate, and precentral gyrus) was also observed. Classification accuracy of 80% for differentiating patients with EMCI from HC was achieved by using the preferred information flow directions. The preferred information flow directions have a good ability to predict memory and executive function, level of amyloid ß, tau protein, and phosphorylated tau protein with the high Pearson's correlation coefficients (r > 0.7) between predictive and actual neurological measures. Conclusion: Patients with EMCI were presented with a disturbed brain information flow pattern, which could help clinicians to identify patients with EMCI and assess their neurological state.

5.
Ren Fail ; 43(1): 1588-1600, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-34865599

RESUMO

BACKGROUND: We aim to develop and validate a nomogram model for predicting severe acute kidney injury (AKI) after orthotopic liver transplantation (OLT). METHODS: A total of 576 patients who received OLT in our center were enrolled. They were assigned to the development and validation cohort according to the time of inclusion. Univariable and multivariable logistic regression using the forward variable selection routine were applied to find risk factors for post-OLT severe AKI. Based on the results of multivariable analysis, a nomogram was developed and validated. Patients were followed up to assess the long-term mortality and development of chronic kidney disease (CKD). RESULTS: Overall, 35.9% of patients were diagnosed with severe AKI. Multivariable logistic regression analysis revealed that recipients' BMI (OR 1.10, 95% CI 1.04-1.17, p = 0.012), hypertension (OR 2.32, 95% CI 1.22-4.45, p = 0.010), preoperative serum creatine (sCr) (OR 0.96, 95% CI 0.95-0.97, p < 0.001), and intraoperative fresh frozen plasm (FFP) transfusion (OR for each 1000 ml increase 1.34, 95% CI 1.03-1.75, p = 0.031) were independent risk factors for post-OLT severe AKI. They were all incorporated into the nomogram. The area under the ROC curve (AUC) was 0.73 (p < 0.05) and 0.81 (p < 0.05) in the development and validation cohort. The calibration curve demonstrated the predicted probabilities of severe AKI agreed with the observed probabilities (p > 0.05). Kaplan-Meier survival analysis showed that patients in the high-risk group stratified by the nomogram suffered significantly poorer long-term survival than the low-risk group (HR 1.92, p < 0.01). The cumulative risk of CKD was higher in the severe AKI group than no severe AKI group after competitive risk analysis (HR 1.48, p < 0.05). CONCLUSIONS: With excellent predictive abilities, the nomogram may be a simple and reliable tool to identify patients at high risk for severe AKI and poor long-term prognosis after OLT.

6.
J Ophthalmol ; 2021: 5580075, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34956667

RESUMO

Purpose: To investigate the clinical characteristics of pregnancy-associated central serous chorioretinopathy (CSC) in the Chinese population. Methods: The medical records of patients diagnosed with pregnancy-associated CSC from February 2012 to October 2019 were retrospectively reviewed. Best-corrected visual acuity (BCVA), symptom duration, pregnancy-related medical information, and optical coherence tomography (OCT) images were collected. Results: Nine patients (11 eyes) were included. Five women were in their first pregnancy and four were in their second pregnancy, two of whom experienced CSC in their first pregnancy as well. The mean age was 35.00 ± 3.97 years. The mean symptom duration at the initial visit was 19.73 ± 13.65 days. The mean gestational age at the time of development of CSC was 27.11 ± 2.09 weeks. The mean BCVA (logarithm of the minimum angle of resolution (logMAR)) at the initial visit was 0.36 ± 0.18 (Snellen 20/45, range 20/100-20/25). All eyes showed subretinal hyperreflective fibrin on OCT images at the initial visit. Four patients (4 eyes) were lost to follow-up before fluid resolution. The mean BCVA at the final visit was logMAR 0.10 ± 0.15 (Snellen 20/25, range 20/50-20/20)). One eye in the oldest patient had persistent subretinal fluid at 26 months postpartum. The subretinal fluid resolved completely after half-dose photodynamic therapy (PDT); however, the ellipsoid zone at the fovea remained discontinuous at 30 months after half-dose PDT. The remaining six eyes all showed spontaneous resolution of subretinal fluid around delivery and regained intact ellipsoid zone. Conclusions: Pregnancy-associated CSC in Chinese developed mostly in the third trimester and usually recovered spontaneously around delivery with good final visual acuity. However, patients might require long-term follow-up until complete resolution of subretinal fluid and to detect recurrences. Half-dose PDT can be administered early if there is little reduction in the amount of subretinal fluid after delivery.

7.
Org Biomol Chem ; 19(46): 10030-10046, 2021 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-34747960

RESUMO

ß-Keto acids, ideal surrogates of inactive ketones, play an important role in organic synthesis. The asymmetric decarboxylative reaction using ß-keto acids is the one which is being studied the most. Herein we present a comprehensive review on this research topic, which is generally classified according to different catalytic systems and chiral induction modes. Additionally, some extended utilities of these methodologies for synthesizing bioactive compounds were also summarized. This review will facilitate the synthetic community to understand the role of ß-keto acids in asymmetric reactions, providing many new opportunities for further exploration in this field.

8.
J Org Chem ; 86(23): 16614-16624, 2021 Dec 03.
Artigo em Inglês | MEDLINE | ID: mdl-34752099

RESUMO

Herein, we report a protocol for PtI2-catalyzed formal three-component cascade cycloaddition reactions between γ-aminoalkynes and electron-deficient alkynes to afford highly substituted cyclohexadiene-b-pyrrolidines in good yields. On the basis of the results of the control experiments and density functional theory calculations, we present a plausible mechanism that proceeds via two key intermediates. The overall transformation involves the cleavage and formation of multiple C-C and C-N bonds and a previously unreported reaction mode of a seven-membered nitrogen heterocyclic intermediate.

9.
Adv Sci (Weinh) ; : e2103041, 2021 Nov 05.
Artigo em Inglês | MEDLINE | ID: mdl-34738729

RESUMO

Although purely organic room-temperature phosphorescence (RTP) has drawn widespread attention in recent years, regulatable phosphorescence resonance energy transfer (PRET) supramolecular switch is still rare. Herein, single molecular dual-fold supramolecular light switches, which are constructed by phenylpyridinium salts modified diarylethene derivatives (DTE-Cn, n = 3, 5) and cucurbit[8]uril (CB[8]) are reported. Significantly, biaxial [3]pseudorotaxane displayed efficiently reversible RTP after binding with CB[8] and the phosphorescence quenching efficiency is calculated up to be 99%. Furthermore, the binary supramolecular assembly can coassemble with Cy5 to form ternary supramolecular assembly showing efficiently PRET, which is successfully applied in switchable near infrared (NIR) mitochondria-targeted cell imaging and photocontrolled data encryption. This supramolecular strategy involving energy transfer provides a convenient approach for phosphorescent application in biology and material fields.

10.
JID Innov ; 1(3)2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-34604833

RESUMO

Neurofibromatosis type 1 (NF1) is one of the most common neurocutaneous genetic disorders, presenting with different cutaneous features such as café-au-lait macules, intertriginous skin freckling, and neurofibromas. Although most of the disease manifestations are benign, patients are at risk for a variety of malignancies, including malignant transformation of plexiform neurofibromas. Numerous studies have investigated the mechanisms by which these characteristic neurofibromas develop, with progress made toward unraveling the various players involved in their complex pathogenesis. In this review, we summarize the current understanding of the cells that give rise to NF1 neoplasms as well as the molecular mechanisms and cellular changes that confer tumorigenic potential. We also discuss the role of the tumor microenvironment and the key aspects of its various cell types that contribute to NF1-associated tumorigenesis. An increased understanding of these intrinsic and extrinsic components is critical for developing novel therapeutic approaches for affected patients.

11.
J Ophthalmol ; 2021: 2003001, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34608417

RESUMO

Purpose: To evaluate the efficacy of internal limiting membrane (ILM) peeling combined with modified flap inverting under air in the treatment of large idiopathic macular hole (MH). Methods: Eyes with a large idiopathic MH (minimum diameter >550 µm) were included in this study. The surgical procedure included standard 23-gauge pars plana vitrectomy (PPV), ILM peeling, complete fluid-gas exchange, and ILM flap inversion under air. The patients underwent follow-up exam including optical coherence tomography (OCT) and best-corrected visual acuity (BCVA) measurement. Results: Sixteen eyes from 16 patients were included. Mean MH diameter was 681.43 ± 112.12 µm. After a mean follow-up time of 6.25 ± 2.65 months, in all cases, the MH was closed, and the ILM flap could be seen at the inner surface of the fovea. U-shaped and V-shaped MH closure was achieved in 11 and 5 cases, respectively. The BCVA improved significantly from 1.49 ± 0.35 logMAR to 0.89 ± 0.35 logMAR (p < 0.05), and visual acuity of 20/100 or better was achieved in 8 eyes. Conclusion: ILM flap inverting under air was helpful in improving the functional and anatomic outcomes of vitrectomy for large idiopathic MH.

12.
Front Cell Dev Biol ; 9: 680600, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34513827

RESUMO

Non-small cell lung carcinoma (NSCLC) is a major neoplastic disease with a high mortality worldwide; however, effective treatment of this disease remains a challenge. Flubendazole, a traditional anthelmintic drug, possesses potent antitumor properties; however, the detailed molecular mechanism of flubendazole activity in NSCLC needs to be further explored. In the present study, flubendazole was found to exhibit valid antitumor activity in vitro as well as in vivo. Flubendazole blocked phosphorylation of STAT3 in a dose- and time-dependent manner and regulated the transcription of STAT3 target genes encoding apoptotic proteins. Further, flubendazole inhibited STAT3 activation by inhibiting its phosphorylation and nuclear localization induced by interleukin-6 (IL-6). Notably, the autophagic flux of NSCLC cell lines was increased after flubendazole treatment. Furthermore, flubendazole downregulated the expression of BCL2, P62, and phosphorylated-mTOR, but it upregulated LC3-I/II and Beclin-1 expression, which are the main genes associated with autophagy. Collectively, these data contribute to elucidating the efficacy of flubendazole as an anticancer drug, demonstrating its potential as a therapeutic agent via its suppression of STAT3 activity and the activation of autophagy in NSCLC.

13.
Eye (Lond) ; 2021 Sep 03.
Artigo em Inglês | MEDLINE | ID: mdl-34480115

RESUMO

OBJECTIVES: To investigate the threshold thickness of the foveal outer nuclear layer (ONL) associated with favourable visual outcome after half-dose photodynamic therapy (PDT) in patients with central serous chorioretinopathy (CSC). METHODS: The CSC patients were divided into two groups according to whether their best-corrected visual acuity (BCVA) at 1 year after half-dose PDT was 20/20 or worse than 20/20. Three multivariable logistic regression models were respectively created to determine the prognostic value of the pre-PDT foveal ONL thickness, the pre- and the post-PDT foveal ONL thickness ratio, which was defined as the foveal ONL thickness in the CSC eye to that in the normal contralateral eye, for predicting the outcome of half-dose PDT. The areas under the receiver operating characteristic curves (AUCs) were compared and the best cut-off values were determined, respectively. RESULTS: Totally, 134 patients were included. The pre-PDT foveal ONL thickness, the pre-PDT and the post-PDT foveal ONL thickness ratios were all independent predictors of the outcome after half-dose PDT in their respective model (all P < 0.05). The AUC of the post-PDT foveal ONL thickness ratio was significantly higher than the AUCs of the other two parameters (0.940 vs 0.840 and 0.882, DeLong test: both P < 0.05), with the cut-off value of 0.81. CONCLUSIONS: The threshold of the foveal ONL thickness ratio is 0.81. Active CSC eyes with a foveal ONL thickness ratio of 0.81 or more could probably retain BCVA of 20/20 after half-dose PDT. They were considered reasonable to wait for spontaneous resolution of sub-retinal fluid.

14.
Oncogene ; 40(39): 5781-5787, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-34345017

RESUMO

Neurofibromatosis Type 1 (NF1) is one of the most common inherited neurological disorders and predisposes patients to develop benign and malignant tumors. Neurofibromas are NF1-associated benign tumors but can cause substantial discomfort and disfigurement. Numerous studies have shown that neurofibromas arise from the Schwann cell lineage but both preclinical mouse models and clinical trials have demonstrated that the neurofibroma tumor microenvironment contributes significantly to tumorigenesis. This offers the opportunity for targeting new therapeutic vulnerabilities to treat neurofibromas. However, a translational gap exists between deciphering the contribution of the neurofibroma tumor microenvironment and clinically applying this knowledge to treat neurofibromas. Here, we discuss the key cellular and molecular components in the neurofibroma tumor microenvironment that can potentially be targeted therapeutically to advance neurofibroma treatment.

15.
J Am Chem Soc ; 143(33): 12913-12918, 2021 Aug 25.
Artigo em Inglês | MEDLINE | ID: mdl-34388341

RESUMO

Allenes are versatile synthons in organic synthesis and medicinal chemistry because of their diverse reactivities. Catalytic 1,4-hydrosilylation of 1,3-enynes may present the straightforward strategy for synthesis of silylallenes. However, the transition-metal-catalyzed reaction has not been successful due to poor selectivity and very limited substrate scopes. We report here the efficient and selective 1,4-hydrosilylation of branched 1,3-enynes enabled by the ene-diamido rare-earth ate catalysts using both alkyl and aryl hydrosilanes, leading to the exclusive formation of tetrasubstituted silylallenes. Deuteration reaction, kinetic study, and DFT calculations were conducted to investigate the possible mechanism, revealing crucial roles of high Lewis acidity, large ionic radius, and ate structure of the rare-earth catalysts.

16.
Polymers (Basel) ; 13(15)2021 Jul 31.
Artigo em Inglês | MEDLINE | ID: mdl-34372156

RESUMO

A novel intumescent flame retardant (IFR) agent designated as Dohor-6000A has been used to prepare halogen-free flame retardant polypropylene (PP) fibers via melting spinning. Before being blended with PP resin, a surface modification of Dohor-6000A was carried out to improve its compatibility with the PP matrix. The rheological behavior of flame retardant Dohor-6000A/PP resin, the structure, morphology, mechanical properties, flammability of the Dohor-6000A/PP fibers were studied in detail, as well as the action mode of flame retardant. X-ray diffraction (XRD) showed that the addition of Dohor-6000A did not damage the crystal as well as the orientation structure of PP matrix, which was helpful to the maintenance of mechanical properties. The presence of the IFR significantly improved the flame retardant performance and thermal stability of PP fibers. When the content of Dohor-6000A reached 25%, the fibers displayed a limiting oxygen index (LOI) value of 29.1% and good melt-drop resistance. Moreover, the peak heat release rate (PHRR) and total heat release (THR) from microscale combustion colorimetry (MCC) tests were decreased by 26.0% and 16.0% in comparison with the same conditions for pure PP fibers. In the condensed phase, the IFR promoted a carbonization process and promoted the formation of a glassy or stable foam protective layer on the surface of the polymer matrix. In addition, the IFR decomposed endothermically to release of non-combustible gases such as NH3 and CO2 which dilutes the combustible gases in the combustion zone.

17.
Front Med (Lausanne) ; 8: 705829, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34307429

RESUMO

Purpose: To investigate the changes in the retinal vessels (RVs) in different sectors in patients with primary open-angle glaucoma (POAG), and their possible correlations with retinal nerve fiber layer thickness (RNFLT) and visual-field defects in the temporal parapapillary region. Methods: The RV diameters, RNFLTs, and visual-field parameters were measured. The temporal parapapillary region was divided into the temporal (T, 315°-45°), temporal superior (TS, 45°-90°), and temporal inferior sectors (TI, 270°-315°). The changes in the RV diameters in each sector were determined, and their relationships with RNFLT, the mean deviation (MD), and visual field sensitivity (VFS) were examined. Results: Fifty POAG patients (50 eyes) and 50 healthy subjects (50 eyes) were included. Compared with the healthy subjects, the POAG group had a significantly smaller accumulated parapapillary RV diameter (P < 0.001), which was positively correlated with the MD and RNFLT. When the different temporal sectors were examined, the accumulated RV diameters were significantly smaller in the POAG group than in the healthy controls in the TI and T sectors, but not in the TS sector. The accumulated diameters in the TI and T sectors were correlated with the corresponding RNFLTs (all P < 0.05), but only the accumulated diameter in the TI sector was correlated with the VFS. Conclusions: In POAG, the changes in the RVs differed between different temporal sectors, with the most prominent changes occurring in the TI and T sectors.

18.
Angew Chem Int Ed Engl ; 60(36): 19860-19870, 2021 09 01.
Artigo em Inglês | MEDLINE | ID: mdl-34213051

RESUMO

Chiral (dihydro)furo-fused heterocycles are significant structural motifs in numerous natural products, functional materials and pharmaceuticals. Therefore, developing efficient methods for preparing compounds with these privileged scaffolds is an important endeavor in synthetic chemistry. Herein, we develop an effective, modular method by a dipeptide-phosphonium salt-catalyzed regio- and stereoselective cascade reaction of readily available linear ß,γ-unsaturated ketones with aromatic alkenes, affording a wide variety of structurally fused heterocyclic molecules in high yields with excellent stereoselectivities. Moreover, mechanistic investigations revealed that the bifunctional phosphonium salt controlled the regio- and stereoselectivities of this cascade reaction, particularly proceeding through the initial ketone α-addition followed by O-participated substitution; and the multiple hydrogen-bonding interactions between Brønsted acid moieties of catalyst and nitro group of aromatic alkene were crucial in asymmetric induction. Given the generality, versatility, and high efficiency of this method, we anticipate that it will have broad synthetic utilities.

19.
Transl Vis Sci Technol ; 10(6): 19, 2021 05 03.
Artigo em Inglês | MEDLINE | ID: mdl-34111263

RESUMO

Purpose: The purpose of this study was to develop a software package for the automatic classification of anterior chamber angle using anterior segment optical coherence tomography (AS-OCT). Methods: AS-OCT images were collected from subjects with open, narrow, and closure anterior chamber angles, which were graded based on ultrasound biomicroscopy (UBM) results. The Inception version 3 network and the transfer learning technique were applied in the design of an algorithm for anterior chamber angle classification. The classification performance was evaluated by fivefold cross-validation and on an independent test dataset. Results: The proposed algorithm reached a sensitivity of 0.999 and specificity of 1.000 in the judgment of closed and nonclosed angles. The overall classification of the proposed method in open angle, narrow angle, and angle-closure classifications reached a sensitivity of 0.989 and specificity of 0.995. Additionally, the sensitivity and specificity reached 1.000 and 1.000 for angle-closure, 0.983 and 0.993 for narrow angle, and 0.985 and 0.991 for open angle. Conclusions: The experimental results showed that the proposed method can achieve a high accuracy of anterior chamber angle classification using AS-OCT images, and could be of value in future practice. Translational Relevance: The proposed deep learning-based method that automate the classification of anterior chamber angle can facilitate clinical assessment of glaucoma.


Assuntos
Aprendizado Profundo , Glaucoma de Ângulo Fechado , Má Oclusão , Câmara Anterior/diagnóstico por imagem , Segmento Anterior do Olho/diagnóstico por imagem , Glaucoma de Ângulo Fechado/diagnóstico , Gonioscopia , Humanos , Tomografia de Coerência Óptica
20.
J Ophthalmol ; 2021: 2653564, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34055394

RESUMO

Purpose: To study the variation of iris thicknesses in different regions and explore the possible correlations with age and gender. Methods: Healthy Chinese adults were recruited; the anterior segment of their eyes was imaged by swept-source optical coherence tomography (SS-OCT). The horizontal scan of the right eye was selected, and the thicknesses of both the nasal and temporal irises were measured at 199 evenly spaced points. Results: A total of 233 subjects with an average age of 36.79 ± 10.04 years (range 19 to 62) were included in the final analysis. The mean iris thicknesses of the temporal and nasal sides were 364.79 ± 47.58 µm and 372.44 ± 43.75 µm, respectively. The mean nasal iris thickness was positively correlated with age (ß = 0.9 µm/year; P = 0.002), but the temporal one was not (ß = 0.077 µm/year; P = 0.806). At 139 points of the nasal iris and 146 points of the temporal iris, the iris thickness was significantly correlated with age (P < 0.05). The thicknesses of the peripheral and pupillary parts were positively correlated with age, while the middle part was negatively correlated with age. No significant difference was observed in the mean iris thickness between genders (temporal: t = 1.597, P = 0.112; nasal: t = 1.870, P = 0.063), but females had a thicker iris than males at 50 points in the temporal side and 49 points in the nasal side (P < 0.05); no point in males was observed to have thicker iris compared to females. Conclusion: Using SS-OCT and the novel method, thicknesses of the iris at different regions were measured. The thicknesses of the peripheral and pupillary irises increase with age, while the thicknesses of the middle part decrease.

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