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1.
Aesthetic Plast Surg ; 2020 Jan 22.
Artigo em Inglês | MEDLINE | ID: mdl-31970453

RESUMO

BACKGROUND: Concentrated growth factors (CGFs) are the latest generation of platelet concentrates. The objective of developing CGF is to increase therapeutic efficacy. However, few studies have supported the superiority of CGF in composition and efficacy. The reconstruction and regeneration process is complicated and long term, whereas bioactivity of CGF is not durable. The purpose of this review is threefold. The first is to recommend more comparative studies between CGF and other platelet concentrates. The second is to constitute a continuous drug delivery system by combining CGF with other biomaterials. Finally, the novel use of CGF in facial regenerative and reconstructive medicine will be highlighted. METHODS: A comprehensive review of literature regarding the use of CGF in facial regenerative and reconstructive medicine was performed. Based on the inclusion and exclusion criteria, a total of 135 articles were included. RESULTS: The use of CGF involving facial rejuvenation, cartilage grafting, facial bone defects, facial peripheral nerve injury and wounding is reviewed. The reconstructive and regenerative principles lie in firm fibrin scaffolds and continuous in situ delivery of multiple growth factors. CONCLUSIONS: CGF represents an advance in personalized medicine concept. However, the current scientific evidences about the use of CGF are limited. More basic and clinical studies should be conducted to understand the characteristics and clinical application of CGF. LEVEL OF EVIDENCE V: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

2.
J Craniofac Surg ; 2020 Jan 20.
Artigo em Inglês | MEDLINE | ID: mdl-31977690

RESUMO

Recently, an increasing trend of the birth prevalence of anotia/microtia is observed in China, contributed by changes of social environment and lifestyle. There seems to be no major breakthroughs in exact pathogenesis of microtia, though the research results related to molecular genetics unceasingly appear. In this review, the authors focus on the results of various research methods which the authors regard as the preferential suspicious gene pool to facilitate the exploration of the pathogenic genes of microtia, knowing that the mechanism of microtia is very complicated. The advantages and limitations of these various approaches will also be systematically delineated. The authors believe that this review will give a deep insight in the genetic research of microtia and help plastic surgeons manage congenital microtia more effectively.

3.
J Craniofac Surg ; 2020 Jan 17.
Artigo em Inglês | MEDLINE | ID: mdl-31977716

RESUMO

Autologous costal cartilage graft is an important material in orthopedic surgery. However, postoperative deformity of costal cartilage in donors is also a matter of concern. In our clinical experience, the preservation of the intercostal perichondrium, the replantation of part of the costal cartilage, and wearing an elastic chest strap for half a year are all ways to avoid thoracic deformity. Methods by which to avoid thoracic deformity is still the focus of our efforts.

4.
J Biomed Mater Res A ; 2020 Jan 11.
Artigo em Inglês | MEDLINE | ID: mdl-31925903

RESUMO

Calcium phosphate (BCP) ceramic is a promising material in bone regeneration because it was proved biocompatible, osteoconductive, osteoinductive, and effective. Although it manifests favorable characteristics in critical-sized bone defects repair, the mechanism of its osteoinduction is still unclear. In the present study, we studied the mechanism of ectopic bone formation, with interest in the Notch signaling pathway. BCP ceramics with or without Notch signaling inhibitor RO4929097 were cocultured with bone marrow-derived stem cells in vitro. The expression of osteogenesis (OPN/Col/Runx2) and Notch signaling pathway-related genes (Hes1/Jagged/Notch1) were increased in the BCP group compared with the control group without BCP but significantly decreased after adding RO4929097. Furthermore, a higher level of alkaline phosphatase activity was observed in the BCP group compared with RO4929097 and control group separately. For further confirmation, the intramuscularly ectopic implantation models of Beagle dogs were used. Quantitative real-time polymerase chain reaction showed a similar trend with the in vitro experiment. Histological and histomorphometric analysis indicated that bone formation was delayed by RO4929097. These findings illustrated that the Notch signaling pathway plays a pivotal role in bone formation induced by BCP; Notch signaling pathway may positively influence ectopic bone formation by promoting BMSCs to differentiate toward osteoblasts.

5.
Int J Pediatr Otorhinolaryngol ; 129: 109771, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31731016

RESUMO

OBJECTIVE: To explore correlations between post-treatment outcomes of non-surgical correction for cryptotia and treatment time and other influence factors. METHODS: Forty-seven consecutive patients with 64 cryptotias were treated with the adjusted external stretching device and followed up over 12 months. A subjective evaluation scale was designed for patients to collect clinical data. Pretreatment and posttreatment evaluation were conducted by two blinded investigators. The correlations between influence factors and outcomes were explored through fractional polynomial method, multiple logistic regression, and robust linear regression methods. RESULTS: Thirty-five patients with 49 cryptotias were included. Twenty-nine cryptotias (23 patients) have been successfully managed. Two of 17 unilateral cryptotias achieved nearly complete symmetry. The final optimal cutoff value for initiating treatment time is 6 months and for the duration of treatment per day is 5 h per day. Positive relationships between initiating treatment time >6 months and onset time, type II and onset time, initiating treatment time >6 months and effect stabilization time were observed. CONCLUSIONS: Initiating treatment time <6 months and duration of treatment per day >5 h benefit for the posttreatment outcomes. Patients wearing the device under 6 months old would have earlier onset time and effect stabilization time. It is hard to achieve complete bilateral symmetry in unilateral patients. The adjustable devices can used for the auricles with different sizes and removed and equipped conveniently.

6.
Int J Pediatr Otorhinolaryngol ; 130: 109801, 2019 Nov 28.
Artigo em Inglês | MEDLINE | ID: mdl-31821964

RESUMO

OBJECTIVE: Numerous corrective methods have been successfully applied in concha-type microtia reconstruction over the past several decades, and autogenous rib cartilage grafting has become a routine technique in a two or three-stage operation. However, it still remains a challenge due to the effective use of the large volume of the remnant cartilage and skin involved. The objective of this study was to clarify how this remnant cartilage and skin could be manipulated for new suitable treatment strategies without autogenous costal cartilage grafting. METHODS: A total of 424 patients with concha-type microtia operated at our Center from January of 2012 to June of 2019 have been reviewed and analyzed cases. At the same time, a classification system for grading the severity of concha-type microtia was created on the basis of anatomical findings and ear size. RESULTS: A total of 436 ear cases (involving 424 patients), showing concha-type microtia, were included in our study and reviewed through medical records, photographs, analysis of surgical methods, and postoperative outcomes. The concha-type microtia were classified into four graded types: Grade I (n = 151), Grade II (n = 101), Grade III (n = 93), and Grade IV (n = 79). A total of 352 ears in 345 patients with Grade I to III concha-type microtia were followed up for 1 month to 7 years (average, 14.7 months). 329 patients (95.4%) were satisfied with the aesthetic outcomes of the corrected ear. CONCLUSIONS: Individual corrective methods and aesthetic outcomes for patients with Grade I to III of deformity were described in this study. The authors present new suitable approaches according to a progressive classification system which provide conservative and individualized methods of treatment in early stages of life.

7.
Exp Ther Med ; 18(6): 4575-4582, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31807147

RESUMO

Objective measurement is important for diagnosing congenital or acquired auricular abnormalities and the evaluation of therapeutic efficacy. However, methods applied in the past were mostly inaccurate and unreliable. The present study aimed to introduce five standardized indices for auricle measurement and present a highly precise and reliable methodology combining three-dimensional (3D) scanning techniques and the Materialise Mimics software for the evaluation of auricle sizes. A total of 20 normal ears were measured independently by four surgeons using the standardized digital method with 3D scanning technique and the traditional manual method. Parameters of the auricle, including the length and width, arc length, cranioauricular height and angle were measured using the Mimics software. Paired t-test, Wilcoxon signed rank test and intra-class correlation coefficients (ICC) were performed on the data to assess the precision, uniformity and observer independence of the method. Pearson's product moment correlation was calculated to assess the correlation between auricle length and width in addition to the correlation between cranioauricular height and angle. No significant differences were indicated between measurements of five auricular parameters made by two surgeons using the digital method. However, significant differences were found using the manual method (P<0.01). ICC values derived from digital measurements ranged from 0.901 to 0.987, whereas those derived from manual measurements ranged from 0.526 to 0.807. These results suggested that the standardized digital method was replicable and reliable compared with the traditional manual method. Pearson's coefficient analysis showed that there was a significant correlation between cranioauricular height and angle (P<0.05), but no correlations were found between the height and width of the auricle (P>0.05). Taken together, data from the present study suggested that measurements of the length and width, arch length, and cranioauricular height and angle of auricles using the standardized digital method combining 3D scanning with the Mimics software were comprehensive, precise, convenient, repeatable and reliable.

8.
ACS Nano ; 13(7): 7483-7492, 2019 Jul 23.
Artigo em Inglês | MEDLINE | ID: mdl-31184133

RESUMO

Nanowires (NWs) have been envisioned as building blocks of nanotechnology and nanodevices. In this study, NWs were manipulated using a weasel hair and fixed by conductive silver epoxy, eliminating the contaminations and damages induced by conventional beam depositions. The fracture strength of the amorphous silicon carbide was found to be 8.8 GPa, which was measured by in situ transmission electron microscopy nanomechanical testing, approaching the theoretical fracture limit. Here, we report that self-healing of mismatched fractured amorphous surfaces of brittle NWs was discovered. The fracture strength was found to be 5.6 GPa on the mismatched fractured surfaces, recovering 63.6% of that of pristine NWs. This is an ultrahigh recovery, due to the limits of reconstruction of dangling bonds on the fractured amorphous surfaces and the mismatched areas. Simulation by molecular dynamics showed fracture strength recovery of 65.9% on the mismatched fractured amorphous surfaces, which is in good agreement with the experimental results. Healing on the mismatched fractured amorphous surfaces is by reorganization of Si-C bonds forming Si-C and Si-Si bonds. The potential energy increases 2.6 eV in the reorganized Si-C bonds and decreases by 3.2 and 1.9 eV, respectively, in the formed Si-C and Si-Si bonds. These findings provide insights for the reliability, design, and fabrication of high performance NW-based devices, to avoid catastrophic failure working in harsh and extreme environments.

9.
Toxicon ; 166: 24-33, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31047933

RESUMO

Scars can have a dramatic impact on patients' physical appearance and function. Injection of botulinum toxin has been used to prevent scar formation at the site of injury and to remodel scars that have already formed. The purpose of this review is to assess the safety and efficacy of botulinum toxin for scar management compared to placebo or no treatment. MEDLINE, EMBASE, Web of Science, the Cochrane Central Register of Controlled Trials and PubMed Central were searched. Nine randomized controlled trials comparing injections of botulinum toxin versus placebo or no treatment for individuals of any age with scars were included and were assessed by two independent review authors. Cochrane risk of bias was used to assess trial quality, sensitivity analyses was conducted and trial sequential analysis was employed to assess the risk of random error. Mean difference (MD), standardized mean difference (SMD) and 95% CI were calculated for continuous outcomes. Risk ratios (RR) and corresponding 95% confidence intervals (CI) were calculated for all dichotomous outcomes. The MD for the Vancouver scar scale (VSS) was -0.87 (95%CI, -1.73 to -0.02), and for the visual analogue scale (VAS) was 1.30 (95%CI, 1.05 to 1.54). The SMD for scar width was -1.05 (95%CI, -1.29 to -0.81). The safety of botulinum toxin therapy was evaluated by calculating adverse events and complications (RR 0.36; 95%CI, 0.09 to 1.45). Evidence from this study has documented the clinical benefits of botulinum toxin versus placebo or no treatment in the prevention and remodeling of scars. Injection of botulinum toxin is both safe and effective. Future studies should focus on the different doses needed and differences in effects between pre-surgical and post-surgical injection periods.


Assuntos
Toxinas Botulínicas Tipo A/efeitos adversos , Toxinas Botulínicas Tipo A/uso terapêutico , Cicatriz/prevenção & controle , Toxinas Botulínicas Tipo A/farmacologia , Cicatriz/tratamento farmacológico , Humanos , Injeções Intralesionais , Segurança do Paciente , Ensaios Clínicos Controlados Aleatórios como Assunto
10.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi ; 33(5): 601-605, 2019 May 15.
Artigo em Chinês | MEDLINE | ID: mdl-31090355

RESUMO

Objective: To preliminarily investigate morghological changes of rabbits reshaping ear cartilage assisted by microdissection needle and explore feasibility of new therapy for ear deformity. Methods: The bilateral ears of 5 male New Zealand rabbits (aged, 5-6 months) were fixed maintaining the curvature and randomly divided into 2 groups (5 ears in each group). The ears were stimulated by microdissection needle in experimental group and were not treated with stimulation in control group. The skin reaction in the experimental group was observed immediately and at 4 weeks after stimulation. Then, the fixtures were removed at 4 weeks, and the shapes of the ears were observed. The cartilages were harvested from the ears to examined morphological changes after HE staining, and measured the chondrocyte layer thickness. Results: All rabbits survived until the end of the experiment. The skin has healed completely after 4 weeks in experimental group. After removing fixtures, the ears in the two groups all maintained certain forms momentarily; while 24 hours later, the ears in the control group mostly recovered original form, and the ears in the experimental group still maintained certain molding form until 8 weeks. HE staining showed there were smooth cartilage and uniform distribution of cells in the control group; the matrix staining was basically consistent; and the skin was normal appearance with epidermis, dermis, and cartilage of normal aspect. But the proliferation of chondrocyte with more layers of cells were observed in the experimental group. In addition, there were degeneration and injury of cartilage cells and connective tissue with necrotic cells and inflammatory cells at needle insertion sites. The chondrocyte layer thickness was (385.714±2.027) µm in the control group and (1 594.732±1.872) µm in the experimental group, there was significant difference between the two groups ( t=-759.059, P=0.000). Conclusion: Rabbit ear cartilage can be effectively reshaped by microdissection needle. Proliferation of chondrocyte and changes in matrix can be found during the reshaping process.


Assuntos
Cartilagem da Orelha , Microdissecção , Animais , Condrócitos , Derme , Masculino , Agulhas , Coelhos
11.
Int Arch Occup Environ Health ; 92(7): 967-975, 2019 10.
Artigo em Inglês | MEDLINE | ID: mdl-30993423

RESUMO

OBJECTIVE: To investigate the effects of the interactions between the CYP2E1 and GOT2 gene polymorphisms and N,N-dimethylformamide (DMF) on liver injury. METHODS: A total of 672 DMF-exposed workers were randomly selected from two synthetic leather enterprises in Suzhou, China, for follow-up in a cohort study. Information on exposure to DMF in the air was collected through a fixed-point air sampler in the worker's breathing zone. The subjects were assessed every year during the period of 2010-2015, they underwent occupational health examinations. Alanine aminotransferase and aspartate aminotransferase levels were measured. Peripheral blood was collected and DNA was extracted. The genotypes rs2031920, rs3813867 and rs6413432 of the CYP2E1 gene and rs7204324 of the GOT2 gene were detected by PCR, and analyzed using the Chi-square test and logistic regression analysis. RESULTS: Workers exposed to a high cumulative dose of DMF were significantly more likely than low-exposed workers to develop liver injury. No association was observed between rs2031920, rs3813867 and rs6413432 of the CYP2E1 gene and DMF-induced liver damage. However, the A allele of rs7204324 on the GOT2 gene may be a risk factor for susceptibility to DMF-induced liver injury. CONCLUSION: Polymorphisms of rs7204324 on GOT2 may play an important role in susceptibility to liver injury following exposure to DMF.

12.
Fitoterapia ; 134: 404-410, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-30898729

RESUMO

Four new C19-diterpenoid alkaloids brevicanines A-D (1-4) with rotameric phenomenon were isolated from Aconitum brevicalcaratum. They all possessed an unusual axial chiral phenyl-quinazoline side chain and their structures were elucidated by extensive spectroscopic analysis and chemical methods. Meanwhile, brevicanines A and B were semi-synthesized from their parent compound scaconine to further confirm their structures. Variable-temperature NMR spectroscopy was also used to investigate the atropisomers of brevicanine A, in which two sets of signals in 1H NMR spectra were observed at room temperature and coalesced over 140 °C. It's the first time to determine the atropisomeric preference of diterpenoid alkaloids.


Assuntos
Aconitum/química , Alcaloides/química , Diterpenos/química , China , Células Hep G2 , Humanos , Células MCF-7 , Estrutura Molecular , Compostos Fitoquímicos/química , Raízes de Plantas/química , Plantas Medicinais/química
15.
Ecotoxicol Environ Saf ; 171: 347-351, 2019 Apr 30.
Artigo em Inglês | MEDLINE | ID: mdl-30616151

RESUMO

BACKGROUND: Current researches show that N,N-dimethylformamide (DMF) exposure is associated with liver injury, but it is debatable whether PNPLA3, GCKR, COL13A1 and TM6SF2 gene polymorphisms are associated with liver injury. Our objective was to examine the relationship among DMF exposure, PNPLA3 rs738409, GCKR rs780094, COL13A1 rs1227756, TM6SF2 rs58542926 and liver injury. METHODS: The cohort consisted of 461 workers exposed above the DMF threshold limit value (TLV) and 211 exposed below the DMF TLV in China, who were followed for 5 years. The relationship between the measured dose of DMF and the relative risk (RR) of liver injury was also investigated by Poisson analysis. Logistic regression models were used to examine the association between measured dose of DMF, gene locus, and RR for liver injury. All workers had a annual physical examinations were conducted at certified physical examination centers in Taicang CDC, including liver serum transaminase assessment and abdominal ultrasound. Genomic DNA was extracted from peripheral blood leukocytes using a genomic DNA extraction kit. RESULTS: The incidence of liver injury in the above DMF TLV group was significantly higher than in the below DMF TLV group. GCKR rs780094 was associated with liver injury. The interaction among the GCKR rs780094, DMF exposure and liver injury showed no significant association. CONCLUSIONS: Our data indicated that in DMF exposure, GCKR rs780094 may contribute to the risk of liver injury. Our results suggest that GCKR rs780094 is a useful genetic marker to help identify liver injury.


Assuntos
Proteínas Adaptadoras de Transdução de Sinal/genética , Doença Hepática Induzida por Substâncias e Drogas/etiologia , Dimetilformamida/toxicidade , Exposição Ocupacional/efeitos adversos , Adulto , Doença Hepática Induzida por Substâncias e Drogas/genética , China , Estudos de Coortes , Colágeno Tipo XIII/genética , Feminino , Interação Gene-Ambiente , Humanos , Lipase/genética , Masculino , Proteínas de Membrana/genética , Pessoa de Meia-Idade , Exposição Ocupacional/análise , Polimorfismo de Nucleotídeo Único , Níveis Máximos Permitidos
16.
Nat Prod Res ; 33(12): 1741-1746, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-29430945

RESUMO

A new C19 diterpenoid alkaloid, brevicanine (1) and six known ones (2-7) were isolated from Aconitum brevicalcaratum (Finet et Gagnep.) Diels. Their structures were elucidated on the basis of extensive spectroscopic analyses. The cytotoxicity of those compounds was investigated against HCT116 human cancer cell line, which showed none of them possessing considerable anti-proliferative activities. To evaluate the autophagy effect of compounds 1-7, Western blot was used to detect the expression of autophagic marker by stimulating human cancer HCT116 cells. The results showed that compound 6 induced protective autophagy in HCT116 cells. Mechanistic insight showed that compound 6 induced protective autophagy through p53 activation, ERK1/2 and p38 MAPK signaling cascade.


Assuntos
Aconitum/química , Autofagia/efeitos dos fármacos , Diterpenos/isolamento & purificação , Alcaloides/química , Alcaloides/isolamento & purificação , Alcaloides/farmacologia , Diterpenos/química , Diterpenos/farmacologia , Células HCT116 , Humanos , Indóis/química , Indóis/isolamento & purificação , Indóis/farmacologia , Quinases de Proteína Quinase Ativadas por Mitógeno/metabolismo , Estrutura Molecular , Análise Espectral , Proteína Supressora de Tumor p53/metabolismo
17.
J Craniofac Surg ; 30(1): e28-e32, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30444766

RESUMO

Autogenous rib cartilage graft procedure for microtia reconstruction has been adopted as the most standardized current method. But calcification would make it difficult for cartilage harvesting and ear framework sculpting. The objective of this study was to explore the rate, degree, and pattern of rib cartilage calcification in microtia and to guide rib cartilage harvesting and the optimal timing of auricular reconstruction. A retrospective study was performed with the imaging data from 320 consecutive patients who received a preoperative 3-dimensional chest computed tomography (CT). Overall, calcification rate of cartilages in female patients was higher than male's (P < 0.05). In 6 to 15 years group, calcification rates of male and female had a similar rate, while female's were higher than male's in other 3 groups. Furthermore, the moderate-to-severe calcification rate was higher in female than in male patients (P < 0.001). Therefore, girls who are over 15 years should be paid more attention regarding the possibility of moderate-to-severe calcification; these patients should take CT examinations if necessary. Calcification rate of the youngest group (6-15 years) was the lowest of all groups, while other 3 groups showed no statistical significance (P > 0.05). So merely the age increasing is not the contradiction for cartilage harvesting, as long as the authors effectively evaluate the condition of rib cartilage before operation. Rib cartilages serve as the key material in auricular framework sculpting and determine the feasibility and outcomes of the surgery. So CT examinations for preoperative evaluation of rib cartilage could be a useful method for planning microtia reconstruction.


Assuntos
Calcinose/diagnóstico por imagem , Microtia Congênita/cirurgia , Cartilagem Costal/diagnóstico por imagem , Cartilagem Costal/transplante , Adolescente , Adulto , Autoenxertos , Criança , Feminino , Humanos , Imagem Tridimensional , Masculino , Pessoa de Meia-Idade , Período Pré-Operatório , Procedimentos Cirúrgicos Reconstrutivos , Estudos Retrospectivos , Fatores Sexuais , Tomografia Computadorizada por Raios X , Adulto Jovem
18.
Medicine (Baltimore) ; 97(45): e12997, 2018 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-30407288

RESUMO

The effects of therapy on constricted ears are evaluated subjectively and objectively. However, previous methods are not specific, comprehensive, precise, or effective in diagnosing and predicting surgical outcomes. This study aimed to present a personalized, subjective evaluation scale and new objective indices utilizing a digital method for the accurate evaluation of constricted ears.Nine consecutive patients with constricted ears were selected. To perform subjective evaluations, the patients' parents were contacted by telephone within 3 to 6 months after surgery and asked to answer questions using a scale. To perform objective evaluations, the constricted and normal ears of each patient were scanned using a 3-dimensional scanner before and 14 days after surgery. The vertical height of the auricle (VHA), transverse diameter of the auricle, minimum length of the helix (MLH), length of the inner auricle (LIA), and transverse diameter of the inner auricle were calculated using Mimics software. The Wilcoxon matched pairs signed-rank test was used for data analysis.High satisfaction scores were reported. The folds of the ear and helix had the highest median scores, whereas the crus of the antihelix had the lowest. The difference in LIA and postoperative MLH was greater than that in VHA and preoperative MLH. The mean values of the 5 indices of the normal ear were greater than those of the indices of the preoperative constricted ear (P < .05).The specialized subjective scale reported in this study allows comprehensive and personalized assessment of constricted ears. The new objective indices are more effective than existing methods and the digital measurement method is precise and reliable. These methods will allow the treatment of constricted ears to be better evaluated, leading to improvements in patient management and treatment selection.


Assuntos
Antropometria/métodos , Pavilhão Auricular/anormalidades , Pré-Escolar , Constrição Patológica/patologia , Constrição Patológica/cirurgia , Pavilhão Auricular/patologia , Pavilhão Auricular/cirurgia , Feminino , Humanos , Lactente , Masculino , Projetos Piloto , Período Pré-Operatório , Procedimentos Cirúrgicos Reconstrutivos/métodos
19.
Plast Reconstr Surg ; 142(6): 892e-903e, 2018 12.
Artigo em Inglês | MEDLINE | ID: mdl-30489530

RESUMO

BACKGROUND: Microtia is a congenital anomaly of the external ear that can appear in isolation or in association with other congenital anomalies. In this study, the authors identify the prevalence and phenotypes of associated congenital malformations in patients with microtia in a Chinese specialty clinic population. METHODS: Data were collected from 672 patients seen between December of 2014 and February of 2016 in the Department of Auricular Reconstruction at the Plastic Surgery Hospital of Peking Union Medical College. All patients were examined by trained clinicians and classified into one of three grades of microtia. Co-occurring congenital anomalies were detected and recorded. RESULTS: The majority of study participants were male patients (72 percent), and most participants had unilateral microtia (93 percent, 68 percent of whom had right-side microtia). Two hundred ninety-three patients (44 percent) had one or more associated anomalies. The most commonly occurring comorbid malformations were those of the ear, face, and neck (40 percent of all associated malformations); musculoskeletal system (35 percent); and cardiovascular system (11 percent). CONCLUSIONS: These data represent the first detailed and thematic study of microtia and associated congenital anomalies in a Chinese clinical population. Substantial clinical heterogeneity was observed, and the prevalence of comorbid congenital malformations was high. Future studies investigating congenital anomalies associated with microtia are needed to improve understanding of its cause.


Assuntos
Microtia Congênita/etnologia , Anormalidades Múltiplas/etnologia , Grupo com Ancestrais do Continente Asiático/etnologia , Feminino , Cardiopatias Congênitas/etnologia , Humanos , Deformidades Congênitas dos Membros/etnologia , Masculino , Anormalidades Maxilofaciais/etnologia , Anormalidades do Sistema Respiratório/etnologia , Tórax/anormalidades
20.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi ; 32(9): 1218-1222, 2018 09 15.
Artigo em Chinês | MEDLINE | ID: mdl-30129340

RESUMO

Objective: To review the surgical treatment progress in repair and reconstruction of acquired auricle defects. Methods: The related literature concerning the surgical methods and techniques for acquired auricle defects was reviewed and summarized. Results: In order to attain an aesthetic ear with a clear structure, the location, size, and condition of surrounding skin must be taken into account when planning excision and repair. The application of tissue engineering and digital technology for acquired auricle defects can achieve a satisfactory effectiveness. Conclusion: The surgical programs for acquired auricular defects have been constantly improved in recent years, and the emerging medical technologies also play a promoting role in the process, which providing a great deal of reference for obtaining structurally clear and stereoscopic auricle.


Assuntos
Pavilhão Auricular , Humanos , Procedimentos Cirúrgicos Reconstrutivos , Retalhos Cirúrgicos
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