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1.
Gene ; 808: 145974, 2022 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-34592348

RESUMO

The mitochondrial genome (mitogenome) has been regarded as significant source of data to better understand the phylogenetic relationships within the Euphasmatodea, but no mitogenome in Aschiphasmatoidea has been sequenced to date. In this study, two mitogenomes of Orthomeria smaragdinum and Nanhuaphasma hamicercum of Aschiphasmatidae were sequenced and annotated for the first time. The same mitochondrial gene rearrangement structure was present in the two mitogenomes sequenced, showing as the translocation of tRNA-Arg and tRNA-Asn, which conformed to the tandem duplication-random loss and could be used as a possible synapomorphy for Aschiphasmatidae. The phylogenetic results based on the maximum likelihood (ML) and bayesian inference (BI) methods both showed that Aschiphasmatidae and Neophasmatodea in Euphasmatodea are sister taxa. Although the monophyly of Oriophasmata, Occidophasmata, Diapheromeridae, Phasmatidae, Lonchodidae and Bacilloidea has not been solved, the monophyly of Neophasmatodea and Phyllioidea was well supported.

2.
Kidney Int ; 2021 Nov 26.
Artigo em Inglês | MEDLINE | ID: mdl-34843754

RESUMO

An increase of glomerular filtration rate (GFR) is a common observation in early diabetes and is considered a key risk factor for subsequent kidney injury. However, the mechanisms underlying diabetic hyperfiltration have not been fully clarified. Here, we tested the hypothesis that macula densa neuronal nitric oxide synthase (NOS1) is upregulated via sodium glucose cotransporter type 1 (SGLT1) in diabetes, which then inhibits tubuloglomerular feedback (TGF) promoting glomerular hyperfiltration. Therefore, we examined changes in cortical NOS1 expression and phosphorylation, nitric oxide production in the macula densa, TGF response, and GFR during the early stage of insulin-deficient (Akita) diabetes in wild-type and macula densa-specific NOS1 knockout mice. A set of sophisticated techniques including microperfusion of juxtaglomerular apparatus in vitro, micropuncture of kidney tubules in vivo, and clearance kinetics of plasma fluorescent-sinistrin were employed. Complementary studies tested the role of SGLT1 in SGLT1 knockout mice and explored NOS1 expression and phosphorylation in kidney biopsies of cadaveric donors. Diabetic mice had upregulated macula densa NOS1, inhibited TGF and elevated GFR. Macula densa-selective NOS1 knockout attenuated the diabetes-induced TGF inhibition and GFR elevation. Additionally, deletion of SGLT1 prevented the upregulation of macula densa NOS1 and attenuated inhibition of TGF in diabetic mice. Furthermore, the expression and phosphorylation levels of NOS1 were increased in cadaveric kidneys of diabetics and positively correlated with blood glucose as well as estimated GFR in the donors. Thus, our findings demonstrate that the macula densa SGLT1-NOS1-TGF pathway plays a crucial role in the control of GFR in diabetes.

3.
Front Pediatr ; 9: 735093, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34733807

RESUMO

Objective: To analyze the clinical characteristics of plastic bronchitis (PB) in children with Mycoplasma pneumoniae pneumonia (MPP) in order to explore its risk factors. Methods: A retrospective analysis was performed in MPP children receiving bronchoscopy admitted to department of respiratory medicine in Shanghai Children's Hospital from January 2018 to December 2020. According to the bronchoscopic findings, the patients were divided into PB group and non-PB group. The clinical manifestations, laboratory examination, etiology, treatment methods and outcomes of the children were analyzed. Logistic regression was used to analyze the risk factors for PB in children with MPP. Results: A total of 296 children with MPP were enrolled in the study, including 42 (14.2%) children in the PB group and 254 (85.8%) children in the non-PB group. There was no difference in the ratios of gender, age, proportion of fever, cough, wet rales, and wheezing rales between the two groups (P > 0.05). The univariate analysis showed that there were significant differences between the PB group and the non-PB group in LDH, D-dimer, CD3+CD4+(%), CD3+CD4+/CD3+CD8+, CD3 count, CD4 count, CD8 count, complement 3, IL8, IL-1ß, IL-2, IL-10 (P < 0.05). The multivariate logistic regression analysis showed that fever duration > 12 d, IL-8 > 2,721.33 pg/ml, LDH > 482 U/L and complement 3 <1.02 g/L were independent risk factors for PB in children with MPP. Conclusions: Children with PB caused by MPP have protracted fever, a strong inflammatory response and immune function disturbance.

4.
Nat Commun ; 12(1): 6312, 2021 Nov 02.
Artigo em Inglês | MEDLINE | ID: mdl-34728627

RESUMO

For iron-based superconductors, the phase diagrams under pressure or strain exhibit emergent phenomena between unconventional superconductivity and other electronic orders, varying in different systems. As a stoichiometric superconductor, LiFeAs has no structure phase transitions or entangled electronic states, which manifests an ideal platform to explore the pressure or strain effect on unconventional superconductivity. Here, we observe two types of superconducting states controlled by orientations of local wrinkles on the surface of LiFeAs. Using scanning tunneling microscopy/spectroscopy, we find type-I wrinkles enlarge the superconducting gaps and enhance the transition temperature, whereas type-II wrinkles significantly suppress the superconducting gaps. The vortices on wrinkles show a C2 symmetry, indicating the strain effects on the wrinkles. By statistics, we find that the two types of wrinkles are categorized by their orientations. Our results demonstrate that the local strain effect with different directions can tune the superconducting order parameter of LiFeAs very differently, suggesting that the band shifting induced by directional pressure may play an important role in iron-based superconductivity.

5.
Inorg Chem ; 60(22): 17371-17378, 2021 Nov 15.
Artigo em Inglês | MEDLINE | ID: mdl-34705457

RESUMO

Electrolysis of seawater can not only desalinate seawater but also produce high-purity hydrogen. Nevertheless, the presence of chloride ions in seawater will cause electrode corrosion and also undergo a chlorine oxidation reaction (ClOR) that competes with the oxygen evolution reaction (OER). Therefore, highly efficient and long-term stable electrocatalysts are needed in this field. In this work, an advanced bifunctional electrocatalyst based on NiFe layered double hydroxide (LDH)/FeOOH heterostructure nanosheets (NiFe LDH/FeOOH) was synthesized on nickel-iron foam (INF) via a simple electrodeposition method. The NiFe LDH/FeOOH electrode demonstrates excellent electrocatalytic activity and stability, which results from the strong interaction between FeOOH and NiFe LDH. Furthermore, ex situ X-ray photoelectron spectroscopy (XPS) and in situ Raman spectroscopy revealed the catalytic process and also demonstrated that the NiFe LDH/FeOOH heterostructure could facilitate the formation of active NiOOH species in the reaction. The obtained NiFe LDH/FeOOH catalyst displays low overpotentials of 181.8 mV at 10 mA·cm-2 for hydrogen evolution reaction (HER) and 286.2 mV at 100 mA·cm-2 for OER in the 1.0 M KOH + 0.5 M NaCl electrolyte. Furthermore, it also exhibits a low voltage of 1.55 V to achieve the current density of 10 mA·cm-2 and works steadily for 105 h at 100 mA·cm-2 for overall alkaline simulated seawater splitting. This work will afford a valid strategy for designing a non-noble metal catalyst for seawater splitting.

7.
Nat Metab ; 3(10): 1357-1371, 2021 10.
Artigo em Inglês | MEDLINE | ID: mdl-34663976

RESUMO

The multifunctional roles of metabolic enzymes allow for the integration of multiple signals to precisely transduce external stimuli into cell fate decisions. Elevation of 3-phosphoglycerate dehydrogenase (PHGDH), the rate-limiting enzyme for de novo serine biosynthesis, is broadly associated with human cancer development; although how PHGDH activity is regulated and its implication in tumorigenesis remains unclear. Here we show that glucose restriction induces the phosphorylation of PHGDH by p38 at Ser371, which promotes the translocation of PHGDH from the cytosol into the nucleus. Concurrently, AMPK phosphorylates PHGDH-Ser55, selectively increasing PHGDH oxidation of malate into oxaloacetate, thus generating NADH. In the nucleus, the altered PHGDH activity restricts NAD+ level and compartmentally repressed NAD+-dependent PARP1 activity for poly(ADP-ribosyl)ation of c-Jun, thereby leading to impaired c-Jun transcriptional activity linked to cell growth inhibition. Physiologically, nuclear PHGDH sustains tumour growth under nutrient stress, and the levels of PHGDH-Ser371 and PHGDH-Ser55 phosphorylation correlate with p38 and AMPK activity, respectively, in clinical human pancreatic cancer specimens. These findings illustrate a previously unidentified nutrient-sensing mechanism with the critical involvement of a non-canonical metabolic effect of PHGDH and underscore the functional importance of alternative PHGDH activity in tumorigenesis.

8.
Int J Biol Sci ; 17(14): 4021-4033, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34671216

RESUMO

Unilateral ischemia reperfusion injury (UIRI) with longer ischemia time is associated with an increased risk of acute renal injury and chronic kidney disease. Exosomes can transport lipid, protein, mRNA, and miRNA to corresponding target cells and mediate intercellular information exchange. In this study, we aimed to investigate whether exosome-derived miRNA mediates epithelial-mesenchymal cell communication relevant to renal fibrosis after UIRI. The secretion of exosomes increased remarkably in the kidney after UIRI and in rat renal tubular epithelium cells (NRK-52E) after hypoxia treatment. The inhibition of exosome secretion by Rab27a knockout or GW4869 treatment ameliorates renal fibrosis following UIRI in vivo. Purified exosomes from NRK-52E cells after hypoxia treatment could activate rat kidney fibroblasts (NRK-49F). The inhibition of exosome secretion in hypoxic NRK-52E cells through Rab27a knockdown or GW4869 treatment abolished NRK-49F cell activation. Interestingly, exosomal miRNA array analysis revealed that miR-150-5p expression was increased after hypoxia compared with the control group. The inhibition of exosomal miR-150-5p abolished the ability of hypoxic NRK-52E cells to promote NRK-49F cell activation in vitro, injections of miR-150-5p enriched exosomes from hypoxic NRK-52E cells aggravated renal fibrosis following UIRI, and renal fibrosis after UIRI was alleviated by miR-150-5p-deficient exosome in vivo. Furthermore, tubular cell-derived exosomal miR-150-5p could negatively regulate the expression of suppressor of cytokine signaling 1 to activate fibroblast. Thus, our results suggest that the blockade of exosomal miR-150-5p mediated tubular epithelial cell-fibroblast communication may provide a novel therapeutic target to prevents UIRI progression to renal fibrosis.

9.
Ecol Evol ; 11(17): 12161-12172, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-34522368

RESUMO

Environmental DNA metabarcoding is becoming a predominant tool in biodiversity assessment, as this time- and cost-efficient tactics have the ability to increase monitoring accuracy. As a worldwide distributed genus, Rheocricotopus Brundin, 1956 still does not possess a complete and comprehensive global DNA barcode reference library for biodiversity monitoring. In the present study, we compiled a cytochrome c oxidase subunit 1 (COI) DNA barcode library of Rheocricotopus with 434 barcodes around the world, including 121 newly generated DNA barcodes of 32 morphospecies and 313 public barcodes. Automatic Barcode Gap Discovery (ABGD) was applied on the 434 COI barcodes to provide a comparison between the operational taxonomic units (OTU) number calculated from the Barcode Index Number (BIN) with the "Barcode Gap Analysis" and neighbor-joining (NJ) tree analysis. Consequently, these 434 COI barcodes were clustered into 78 BINs, including 42 new BINs. ABGD yielded 51 OTUs with a prior intraspecific divergence of Pmax = 7.17%, while NJ tree revealed 52 well-separated clades. Conservatively, 14 unknown species and one potential synonym were uncovered with reference to COI DNA barcodes. Besides, based on our ecological analysis, we discovered that annual mean temperature and annual precipitation could be considered as key factors associated with distribution of certain members from this genus. Our global DNA barcode reference library of Rheocricotopus provides one fundamental database for accurate species delimitation in Chironomidae taxonomy and facilitates the biodiversity monitoring of aquatic biota.

10.
Adv Mater ; 33(45): e2103186, 2021 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-34536029

RESUMO

Highly active catalysts that can directly utilize renewable energy (e.g., solar energy) are desirable for CO2 value-added processes. Herein, aiming at improving the efficiency of photodriven CO2 cycloaddition reactions, a catalyst composed of porous carbon nanosheets enriched with a high loading of atomically dispersed Al atoms (≈14.4 wt%, corresponding to an atomic percent of ≈7.3%) coordinated with N (AlN4 motif, Al-N-C catalyst) via a versatile molecule-confined pyrolysis strategy is reported. The performance of the Al-N-C catalyst for catalytic CO2 cycloaddition under light irradiation (≈95% conversion, reaction rate = 3.52 mmol g-1 h-1 ) is significantly superior to that obtained under a thermal environment (≈57% conversion, reaction rate = 2.11 mmol g-1 h-1 ). Besides the efficient photothermal conversion induced by the carbon matrix, both experimental and theoretical analysis reveal that light irradiation favors the photogenerated electron transfer from the semiconductive Al-N-C catalyst to the epoxide reactant, facilitating the formation of a ring-opened intermediate through the rate-limiting step. This study not only provides an advanced Al-N-C catalyst for photodriven CO2 cycloaddition, but also furnishes new insight for the rational design of superior photocatalysts for diverse heterogeneous catalytic reactions in the future.

11.
Nanoscale ; 13(37): 15789-15803, 2021 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-34528979

RESUMO

The immunosuppressive tumor microenvironment has become a formidable obstacle to the treatment of tumors using adoptive T cell therapy, in particular solid tumors. For the purposes of addressing this issue, effector OT-1 CD8+T cells conjugated with liposomal immune regulators (CD8-T-LP-CpG/CD8-T-LP-BMS-202) were developed. An anionic liposome formulation was employed to avoid T cell aggregation and prevent unfavorable side-effects. The inclusion of EGCG in the LP-CpG formulation facilitated the formation of compact complexes with poly lysine (PLL) and is thus expected to increase the stability. CD8-T-LP-CpG administered with a median dose of CpG (20 µg per mouse) markedly reduced the frequency of tumor infiltrating polymorphonuclear leukocyte myeloid-derived suppressor cells (PMN-MDSCs) (20-folds), M2-like macrophages (8-folds), regulatory T-cells (Treg) (2.7-folds), and consequently increased the frequency of cytotoxic CD8+T cells in tumor-infiltrating lymphocytes (TILs) (2-folds) and splenic effector memory CD8+T cells (3-folds) relative to the phosphate buffered saline (PBS) control group. Furthermore, the absolute number of tumor infiltrating lymphocyte subtypes altered followed a consistent trend. The difference remained significant compared to the OT-1 CD8+T cells and the drug-loaded liposome combination group. According to in vivo imaging of CD8-T-LP-DiD, we assumed that the improvement in regulation of the tumor microenvironment of LP-CpG/LP-BMS-202 was attributed to the enhanced drug transportation to the tumor site aided by tumor-specific OT-1 CD8+T cells. In addition, CD8-T-LP-BMS-202 administered with a low dose of BMS-202 (1.5 mg per kg body weight) exerted a dramatically improved therapeutic effect by reducing the tumor infiltrating PMN-MDSCs and M2-like macrophages and the corresponding promoted cytotoxic CD8+T cell recruitment in the TILs and effector memory CD8+T cells mediated anti-tumor immunity. In summary, immune therapy drugs backpacked onto adoptive T cell therapy provides a feasible strategy to improve the therapeutic effect and could result in future clinical translation.


Assuntos
Melanoma , Microambiente Tumoral , Animais , Linfócitos T CD8-Positivos , Imunoterapia , Lipossomos , Camundongos , Camundongos Endogâmicos C57BL
12.
Angew Chem Int Ed Engl ; 60(42): 22740-22744, 2021 Oct 11.
Artigo em Inglês | MEDLINE | ID: mdl-34431193

RESUMO

Seawater electrolysis to produce hydrogen is a critical technology in marine energy projects; however, the severe anode corrosion caused by the highly concentrated chloride is a key issue should be addressed. In this work, we discover that the addition of sulfate in electrolyte can effectively retard the corrosion of chloride ions to the anode. We take nickel foam as the example and observe that the addition of sulfate can greatly improve the corrosion resistance, resulting in prolonged operating stability. Theoretical simulations and in situ experiments both demonstrate that sulfate anions can be preferentially adsorbed on anode surface to form a negative charge layer, which repulses the chloride ions away from the anode by electrostatic repulsion. The repulsive effect of the adsorbed sulfate is also applicable in highly-active catalyst (nickel iron layered double hydroxide) on nickel foam, which shows ca. 5 times stability of that in traditional electrolyte.

13.
Int Immunopharmacol ; 99: 108022, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34339961

RESUMO

Cisplatin is a highly effective and broad-spectrum anticancer drug for the clinical treatment of solid tumors. However, it causes acute kidney injury (AKI) in patients with cancer. Consequently, its clinical application is limited. The occurrence, development, and prognosis of AKI are closely associated with microRNA (miRNA), which needs validation as a biomarker, especially for the early stages of cisplatin-induced AKI. An example of miRNA is miR-132-3p, which plays important roles in inflammatory responses, cell proliferation, and apoptosis in a variety of diseases. However, variations in its expression, potential mechanisms, and downstream targets in cisplatin-induced AKI remain unclear. This study aimed to investigate the functions of miR-132-3p in cisplatin-induced AKI. Sequencing and qRT-PCR revealed that miR-132-3p was significantly upregulated in cisplatin-induced AKI models of mouse and human proximal renal tubular epithelial (HK-2) cells. Apoptosis and inflammatory responses were significantly suppressed by the inhibition of the miR-132-3p expression in cisplatin-stimulated HK-2 cells, and this suppression was blocked by miR-132-3p mimics. Bioinformatics and dual luciferase reporter gene assay identified the 3'- UTR of SIRT1 mRNA as a direct target of miR-132-3p. RNA-FISH and immunofluorescence co-localization demonstrated that miR-132-3p and SIRT1 directly combined and interacted in the cytoplasm of HK-2 cells. Mechanistically, the SIRT1 expression was suppressed and the NF-κB signaling pathway was activated by the upregulation of miR-132-3p in cisplatin-induced AKI. By contrast, the SIRT1 expression was upregulated after the inhibition of miR-132-3p. The ratios of p-p65/p65 and p-IκBα/IκBα were significantly reduced, and the expression levels of inflammatory biomarkers and apoptotic proteins induced by cisplatin were obviously attenuated. Our results suggested that miR-132-3p exacerbated cisplatin-induced AKI by negatively regulating SIRT1 and activating the NF-κB signaling pathway. Therefore, targeting miR-132-3p might be a potential adjuvant therapy for ameliorating AKI in cisplatin-treated patients.

14.
SAGE Open Med Case Rep ; 9: 2050313X211041838, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34457305

RESUMO

A synchronous tumor represents two histologically distinct neoplasms occurring at the same anatomic site, each displaying a distinct tumorigenesis pathway; they can be primary, secondary, or a mixture. The occurrence of an adenocarcinoma and lymphoma has been reported in gastrointestinal and pulmonary sites; however, such a finding in hepatobiliary system remains elusive. Primary hepatic lymphoma is rare, while primary biliary mucosa-associated lymphoid tissue lymphoma is an even rarer event; hence, its collision with an intrahepatic cholangiocarcinoma could be entirely missed both in practice and in the literature. We herein reported a case of biliary mucosa-associated lymphoid tissue lymphoma occurring synchronously with an intrahepatic cholangiocarcinoma in a 78-year-old female following a biopsy-proven intrahepatic cholangiocarcinoma and hepatectomy. Microscopic examination identified atypical lymphoid population intermingled with this intrahepatic cholangiocarcinoma. An immunohistochemical panel uncovered an incidental mucosa-associated lymphoid tissue lymphoma occurring with this intrahepatic cholangiocarcinoma. This clinically missed entity led to comprehensive systemic investigation/staging, with subsequent detection of bone marrow involvement by stage IV lymphoma. This unique case highlights the importance of astute histomorphological evaluation and thorough ancillary studies in identifying a clinically unsuspected neoplasm in close contact with a known tumor.

15.
Adv Mater ; 33(36): e2100074, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-34297448

RESUMO

The high viscosity and low fluidity of heavy crude oil hinder its sorption by conventional porous sorbents, so the efficient clean-up of such heavy crude oil spills is challenging. Recently, Joule heating has been emerging as a new tool to reduce the viscosity of heavy crude oil dramatically. However, this direct-contact heating approach presents a potential risk due to the high voltage applied. To develop a non-contact recovery of viscous crude oil, here, a new approach for the fabrication of a series of ferrimagnetic sponges (FMSs) with hydrophobic porous channels is reported, whose surface can be remotely heated to 120 °C within 10 s under an alternating magnetic field (f = 274 kHz, H = 30 kA m-1 ). Compared with the solar-driven superficial heating, the integral magnetic heating in FMSs can result in a higher internal temperature of the sponges because of the confinement of thermal transport in the porous channels, which contributes to a dramatic decrease in oil viscosity and a significant increase in oil flow into the pores of FMSs. Furthermore, FMSs assembled with a self-priming pump can achieve continuous recovery of viscous crude oil (33.05 g h-1 cm-2 ) via remotely magnetic heating.

16.
Cancer Manag Res ; 13: 5251-5261, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34234567

RESUMO

Aim: Enhanced recovery after surgery (ERAS) gradually shortens the length of stay but increases the rate of unplanned readmission after discharge. Currently, objective discharge criteria for patients after radical gastrectomy is lacking. This study aimed to construct and validate a nomogram for estimation of the possibility of safe discharge on the fifth-day post radical gastrectomy. Methods: We enrolled 496 consecutive patients undergoing radical gastrectomy as the development cohort. After the fifth day of surgery, patients were assigned to the postoperative complication group and no postoperative complication group. Multivariate logistic regression analyses were performed for both groups. Then, we constructed the risk prediction model of postoperative severe complications (PSCs) and applied it to evaluate whether the patient could be discharged safely. The external validation cohort comprised 245 patients, whom we used to evaluate the capability of our model to predict the risk of PSCs. The primary measure was the negative predictive rate (NPR) and the area under the curve (AUC). Results: Through multivariate analysis, gender, maximum body temperature on the 4th postoperative day (POD4), oral intake and ambulatory duration on POD4, the proportion of neutrophils (≥75% or <75%) and pain score (≥4 or <4) on POD5, and defecation with 5 days after the procedure (yes or no) were identified as independent predictors for PSCs. Upon incorporation of these variables, the nomogram demonstrated a good NPR of 0.957 and 0.916 and AUC of 0.918 and 0.719 in the two cohorts, respectively. With a nomogram score of 110, patients were stratified into low and high risk of PSCs. Conclusion: The nomogram demonstrated good predictive potential for low-risk patients. It could serve as an objective safe discharge approach for patients after the fifth day of radical gastrectomy.

17.
Nanomaterials (Basel) ; 11(6)2021 Jun 18.
Artigo em Inglês | MEDLINE | ID: mdl-34207483

RESUMO

A highly efficient adsorbent for methylene blue (MB) adsorption was developed by combination of carboxymethyl cellulose (CMC) and graphene oxide (GO) via a simple one-step hydrothermal method. The as-synthesized CMC/GO composite aerogel has a mesoporous structure with an average pore diameter of 30 nm and a high specific surface area of 800.85 m2·g-1. Moreover, the CMC/GO composite aerogel demonstrates a significant selectivity for the dye adsorption, especially for MB, where its adsorption capacity can reach 244.99 mg·g-1 with an excellent recyclability for more than nine times. Thus, the prepared CMC/GO composite aerogel would be an effective adsorbent for dyes adsorption, owing to the merits of high efficiency, reusability, and eco-friendliness.

18.
J Colloid Interface Sci ; 604: 767-775, 2021 Dec 15.
Artigo em Inglês | MEDLINE | ID: mdl-34303884

RESUMO

Efficient generation of hydrogen from electrocatalytic water-splitting is of great importance to realize the hydrogen economy. In that field, designing efficient and bifunctional electrocatalysts for oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) is critical for water splitting. With the increasing demands for bifunctional catalysts, a universal strategy in favor of these catalytic processes is particularly important. Herein, a variety of Zr-doped layered double hydroxide (LDH) with low-crystalline grown on nickel foam (NF) is designed to promote the bifunctional activities of electrocatalysts. It is found that the doping of Zr4+ into CoFe-LDH/NF can tune the electronic structure and also expose abundant catalytic active sites to enhance the electrocatalytic activities. In 1 M KOH, the as-prepared CoFeZr/NF exhibits superior OER and HER activities with low overpotentials of 233 and 159 mV at 10 mA cm-2. When tested in alkaline simulated seawater electrolyte, CoFeZr/NF also shows high catalytic activities with almost no attenuation when compared with that in 1.0 M KOH. This work will provide a new way for the development of seawater electrolysis for large-scale hydrogen production.

19.
AAPS PharmSciTech ; 22(6): 208, 2021 Jul 26.
Artigo em Inglês | MEDLINE | ID: mdl-34312742

RESUMO

Pediatric drug development faces many difficulties. Traditionally, pediatric drug doses are simply calculated linearly based on the body weight, age, and body surface area of adults. Due to the ontogeny of children, this simple linear scaling may lead to drug overdose in pediatric patients. The physiologically based pharmacokinetic (PBPK) model, as a mathematical model, contributes to the research and development of pediatric drugs. An example of a PBPK model guiding drug dose selection in pediatrics has emerged and has been approved by the relevant regulatory agencies. In this review, we discuss the principle of the PBPK model, emphasize the necessity of establishing a pediatric PBPK model, introduce the absorption, distribution, metabolism, and excretion of the pediatric PBPK model, and understand the various applications and related prospects of the pediatric PBPK model.


Assuntos
Desenvolvimento de Medicamentos , Modelos Biológicos , Pediatria , Adulto , Criança , Simulação por Computador , Humanos , Farmacocinética , Projetos de Pesquisa
20.
Zhongguo Yi Liao Qi Xie Za Zhi ; 45(3): 266-270, 2021 Jun 08.
Artigo em Chinês | MEDLINE | ID: mdl-34096233

RESUMO

Based on the existing information construction foundation of the isolation ward of the hospital, according to the relevant guidelines issued by the National Health Commission, the management of environmental isolation, disinfection, medical staff management and patient management are discussed, combining the application of Internet of things technology in hospital management, a series of new applications with distinctive features of Internet of Things (IoT) are built, and advanced technology and equipment such as Internet of Things are introduced. Realize the application scenario, implementation method and business mode of intelligent IoT in isolation ward, form an integrated data management center and monitoring system through data intelligent IoT, aggregation and operation, and realize the digital collection, processing, storage, transmission and analysis of medical information, equipment information, personnel information and management information, so as to realize medical closed-loop management, reduce the hidden danger of medical safety in isolated wards and improve the level of medical quality.


Assuntos
Internet das Coisas , Hospitais , Humanos , Internet , Monitorização Fisiológica , Tecnologia
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