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1.
Neuromolecular Med ; 2020 Jan 13.
Artigo em Inglês | MEDLINE | ID: mdl-31933131

RESUMO

As a type of stress, maternal separation (MS) has been one of the most widely used models in neuropsychiatric research. An increasing number of studies has found that MS not only affects the function of the hypothalamic-pituitary-adrenal axis and hippocampal 5-hydroxytryptamine system, but also causes dysfunction of the central dopamine (DA) system and increases the susceptibility of dopaminergic neurons to pathogenic factors of Parkinson's disease (PD), for instance, 6-hydroxydopamine, thus impairing motor function. We reviewed the impact of MS on the DA system and its correlation with PD and found the following: (1) discrepant effects of MS on the DA system have been reported; (2) MS is a good model to study the impact of stress on the occurrence and development of PD, however, unified modeling criteria of MS are required; (3) correlation between MS and PD may involve the impact of MS on the DA system, which however is not the only connection; (4) intervening measures can block pathways between MS and PD, which provides reference for the prevention of PD in specific populations such as left-behind children.

2.
Medicine (Baltimore) ; 98(44): e17826, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31689870

RESUMO

Current study was to evaluate the prevalence of guideline recommended medications adherence in myocardial infarction (MI) patients postpercutaneous coronary intervention (PCI) and the association of medication nonadherence and major adverse cardiovascular events (MACEs).MI patients who underwent PCI in the last 12 months were enrolled. Demographic and clinical characteristics were collected and guideline recommended medications were evaluated. Patients were divided into with and without MACEs groups.Compared to patients without MACEs, those with MACEs were older (54.8 ±â€Š16.4 vs 51.1 ±â€Š15.2 years), more likely to be smoker (40.2% vs 31.9%), have higher body mass index (BMI; 25.0 ±â€Š6.1 vs 23.8 ±â€Š5.7 kg/m), diabetes (47.5% vs 37.8%), ischemic stroke (34.4% vs 25.6%), and estimated lower glomerular filtration rate (85.4 ±â€Š9.6 vs 92.6 ±â€Š10.7 mL/minute/1.73 m). Patients with MACEs were also more likely to present with ST-elevation MI (STEMI; 54.1% vs 48.4%) and to undergo urgent PCI (62.3% vs 56.3%). Furthermore, patients with MACEs were less likely to adhere to dual antiplatelet therapy (77.9% vs 85.9%), renin-angiotensin system inhibitor (62.3% vs 69.7%), and beta-blocker (69.7% vs 72.8%) treatment. In unadjusted model, medication nonadherence was associated with 2-fold higher odds of MACEs. After adjustment for demographics, risk factors, comorbidities, and peri-PCI characteristics, medications nonadherence remained independently associated with MACEs, with odds ratio of 1.40 (95% confidence interval: 1.29-1.87).Medications adherence rate among MI patients post-PCI is suboptimal in China, which is independently associated with MACEs.


Assuntos
Fármacos Cardiovasculares/uso terapêutico , Doenças Cardiovasculares/epidemiologia , Adesão à Medicação/estatística & dados numéricos , Infarto do Miocárdio/tratamento farmacológico , Adulto , Idoso , China/epidemiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Infarto do Miocárdio/cirurgia , Intervenção Coronária Percutânea , Prevalência
3.
Sci Total Environ ; 685: 856-866, 2019 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-31247434

RESUMO

Oil spills are major threats to marine ecosystems. Here, we establish a three-dimensional oil spill model to simulate and project the short- and long-term trajectories of oil slicks and oil-contaminated water that leaked from the Sanchi wreckage. The pollution probability in surrounding areas for the period up to 180 days after the Sanchi sank is statistically analysed. The short-term simulations are consistent with synchronous SAR images and observational reports. The potentially polluted areas depend on the properties of the released oil. The coastal areas most likely to be affected by the bunker oil are located in the Ryukyu Island Chain, Tsushima Strait, on the south and east coasts of Japan. Approximately 50% to 70% of oil particles remain in the ocean and mainly expand along the Ryukyu Island Chain and the region southeast of the Sanchi wreck. Subsurface oil-contaminated water is likely to enter the Sea of Japan along the Tsushima Strait. Due to the rapid evaporation rate of condensate oil, the potentially polluted area is confined to regions within a 100 × 100 km area around the location of the shipwreck, and the contaminated region is closely associated with the surface wind.

4.
Int J Occup Saf Ergon ; : 1-9, 2018 Sep 17.
Artigo em Inglês | MEDLINE | ID: mdl-30221592

RESUMO

In this study, common flame-retardant fabrics were treated with single washing or abrasion and their interactions to simulate wearing away during use. The changes in thickness, mass/m2 and protective performance of the fabrics under both flame and radiation environments were evaluated. Results demonstrated that the protective performance was firstly increased after washing or abrasion, and then decreased with further increasing washing or abrasion cycles. After certain treatment cycles, the combined effect of washing and abrasion was significantly greater than the single effect of washing or abrasion alone. The interaction modes of washing and abrasion also showed significant differences in protective performance under a flame test. Under radiation exposure, the effect of combined washing and abrasion was more obvious. There was a positive correlation between the fabric weight and its protective performance with different treatments. The findings provide useful guidance for the actual use and maintenance of protective clothing.

5.
Opt Express ; 21(1): 1076-86, 2013 Jan 14.
Artigo em Inglês | MEDLINE | ID: mdl-23389001

RESUMO

A three-layered Ag-low-permittivity (LP)-high-permittivity (HP) nanoshell is proposed as a plausible meta-atom for building the three-dimensional isotropic negative refractive index metamaterials (NIMs). The overlap between the electric and magnetic responses of Ag-LP-HP nanoshell can be realized by designing the geometry of the particle, which can lead to the negative electric and magnetic polarizabilities. Then, the negative refractive index is found in the random arrangement of Ag-LP-HP nanoshells. Especially, the modulation of the middle LP layer can move the negative refractive index range into the visible region. Because the responses arise from the each meta-atom, the metamaterial is intrinsically isotropic and polarization independent. It is further found with the increase of the LP layer thickness that the negative refractive index range of the random arrangement shows a large blue-shift and becomes narrow. With the decrease of the filling fraction, the negative refractive index range shows a blue-shift and becomes narrow while the maximum of the negative refractive index decreases.

6.
Opt Express ; 20(24): 26559-67, 2012 Nov 19.
Artigo em Inglês | MEDLINE | ID: mdl-23187511

RESUMO

The influences of the symmetry-breaking on the plasmon resonance couplings in the isolated gold nanotube and the gold nanotube dimer have been investigated by means of the finite element method. It is found that the core offset of gold nanotubes leads to the red-shifts of the low energy modes and the enhanced near-field on the thin shell side of the symmetry-broken gold nanotube (SBGNT). In the weak coupling model of the SBGNT dimer, the interference of the bonding octupole mode of the dimer with the dipole modes causes a strong Fano-like resonance in scattering spectrum. The Fano dip shows a red-shift and becomes deep with the increase of the offset-value. In the strong coupling model of the SBGNT dimer, the coupling between two SBGNTs induces giant electric field enhancement at the gap of the dimer, which is much larger than that in the symmetry gold nanotube dimer. The SBGNT with larger offset-value exhibits stronger near-field at the "hot spot".


Assuntos
Simulação por Computador , Ouro/química , Luz , Modelos Teóricos , Polímeros/química , Ressonância de Plasmônio de Superfície/instrumentação , Dimerização , Humanos , Nanotubos
7.
J Chem Phys ; 136(3): 034502, 2012 Jan 21.
Artigo em Inglês | MEDLINE | ID: mdl-22389906

RESUMO

The influences of the anisotropic permittivity and permeability in inner core on the Fano resonance have been investigated in Ag nanoshell by means of Mie scattering theory. The decreased inner core radius can enhance the coupling between superradiant and subradiant dipole modes and hence a distinct Fano profile. With increasing the tangential permittivity or permeability of inner core, the Fano resonance shows a redshift and the magnitude of Fano profile increases. The variation of Fano resonance with anisotropic permeability of the core is much weaker than that induced by anisotropic permittivity. We further find that the combined action of the increased tangential permittivity and permeability of inner core can induce a significant enhancement of Fano resonance in Ag nanoshell.


Assuntos
Nanopartículas Metálicas/química , Prata/química , Ressonância de Plasmônio de Superfície , Anisotropia
8.
Hua Xi Kou Qiang Yi Xue Za Zhi ; 27(5): 535-7, 2009 Oct.
Artigo em Chinês | MEDLINE | ID: mdl-19927727

RESUMO

OBJECTIVE: To compare the expression of CCL28 in minor and major salivary glands and clarify the role it plays in IgA secreting by minor salivary glands in oral cavity. METHODS: Labial gland and parotid samples were analyzed with real-time fluorescent quantitative PCR assay for CCL28 mRNA. Rank-sum test was used for data analysis using SPSS 10.0 software package. RESULTS: CCL28 mRNA was abundantly expressed in labial glands of healthy adults. Its expression was higher than that in parotids (P<0.01). CONCLUSION: The results of this article suggest that the expression level of CCL28 in labial glands is remarkably higher than that in parotids, which reminds us that the high concentration of IgA in minor salivary glands may be associated with their high expression of CCL28.


Assuntos
Lábio , Glândulas Salivares Menores , Adulto , Humanos
9.
Se Pu ; 23(2): 158-63, 2005 Mar.
Artigo em Chinês | MEDLINE | ID: mdl-16013559

RESUMO

The similarity evaluation of the fingerprints is one of the most important problems in the quality control of the traditional Chinese medicine (TCM). Similarity measures used to evaluate the similarity of the common peaks in the chromatogram of TCM have been discussed. Comparative studies were carried out among correlation coefficient, cosine of the angle and an improved extent similarity method using simulated data and experimental data. Correlation coefficient and cosine of the angle are not sensitive to the differences of the data set. They are still not sensitive to the differences of the data even after normalization. According to the similarity system theory, an improved extent similarity method was proposed. The improved extent similarity is more sensitive to the differences of the data sets than correlation coefficient and cosine of the angle. And the character of the data sets needs not to be changed compared with log-transformation. The improved extent similarity can be used to evaluate the similarity of the chromatographic fingerprints of TCM.


Assuntos
Cromatografia Líquida de Alta Pressão/métodos , Medicamentos de Ervas Chinesas/análise , Medicina Tradicional Chinesa , Mapeamento de Peptídeos/métodos , Fracionamento Químico/métodos , Modelos Químicos , Controle de Qualidade , Reprodutibilidade dos Testes
10.
J Pharm Biomed Anal ; 34(1): 239-45, 2004 Jan 27.
Artigo em Inglês | MEDLINE | ID: mdl-14738940

RESUMO

A sensitive and stereospecific high-performance liquid chromatography (HPLC) method for determination of sertraline in bulk drug, tablets and capsules was developed. Chromatography resolution of the sertraline enantiomeric forms and trans diastereoisomers was performed on Alltima C18 (250 mm x 4.6mm i.d., 5 microm) column with hydroxypropyl-beta-cyclodextrin (HP-beta-CD) as mobile phase additive. The composition of the mobile phase was 68:32 (v/v) aqueous 170 mM phosphate buffer, pH 3.0 (adjusted with 85% phosphoric acid) containing 18 mM HP-beta-CD/acetonitrile at a flow rate of 1.0 ml x min(-1). The UV detector was set at 225 nm. Calibration curves were linear (r=0.9999, n=9) in the range of 1-120 microgml (-1) for sertraline. Limit of detection and quantitation for sertraline was 0.029 and 0.097 microg x ml (-1). The values of R.S.D. of repeatability and intermediate precision for bulk drug, tablets and capsules of sertraline hydrochloride were less than 1.0%.


Assuntos
Ciclodextrinas/análise , Sertralina/análise , beta-Ciclodextrinas , 2-Hidroxipropil-beta-Ciclodextrina , Cápsulas , Cromatografia Líquida de Alta Pressão/métodos , Ciclodextrinas/química , Sertralina/química , Comprimidos
11.
J Chromatogr Sci ; 42(10): 545-50, 2004.
Artigo em Inglês | MEDLINE | ID: mdl-15768842

RESUMO

The Pearson product-moment correlation coefficient is being used to evaluate the similarity of the high-performance liquid chromatographic fingerprints of traditional Chinese medicine (TCM) in China. It is confirmed that a large range of peak areas produced the wrong results. A new algorithm concerning weighted Pearson product-moment correlation coefficient is proposed in this article. The results for both real cases and simulated data sets show that the weighted Pearson product-moment correlation coefficients allow relatively larger differences for large values, smaller differences for small values, and more reliable results than the unweighted Pearson product-moment correlation coefficients. Weight selection depends on the specific scientific problem.

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