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1.
Alcohol Alcohol ; 2020 Jun 02.
Artigo em Inglês | MEDLINE | ID: mdl-32484205

RESUMO

AIMS: We conducted a dose-response meta-analysis to explore the association between alcohol and particular alcoholic beverages with risk of esophageal cancer (EC) by histological type [esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC)] and whether the association differs according to gender. METHODS: PubMed and Web of Science databases were searched for relevant articles published between January 1960 and December 2019. The pooled relative ratios (RRs) and 95% confidence interval (CI) were calculated with the fixed or random effect model. The dose-response relationship was assessed by restricted cubic spline. RESULTS: A total of 74 published articles involving 31,105 cases among 3,369,024 participants were included in this meta-analysis. The pooled RRs of the highest versus lowest alcohol intake were 3.67 (95% CI, 2.89,4.67) for EC, 5.11 (95% CI, 3.60,7.25) for ESCC and 0.96 (95% CI, 0.79,1.16) for EAC. The above-mentioned associations were observed in cohort design, for different alcoholic beverages (beer, wine and liquor/spirits) and gender. Evidence of a nonlinear dose-response relationship for EC risk with alcohol intake was found (Pnon-linearity < 0.001), and a linear relationship (Pnon-linearity = 0.216) suggested that the risk of ESCC increased by 33% for every 12.5 g/day increment of alcohol intake. CONCLUSIONS: This meta-analysis suggests that alcohol intake might significantly increase the incidence of EC, especially for ESCC.

2.
Nanoscale ; 2020 May 06.
Artigo em Inglês | MEDLINE | ID: mdl-32373816

RESUMO

Two spirocyclic aromatic hydrocarbon derivatives were prepared to clarify the molecular geometry effects on the regulation of the crystalline morphologies and photophysical behaviors of organic nanocrystals. Due to the different structural symmetry of a spiro-center, distinguishing nanocrystal morphologies with unique crystallization-enhanced/quenched emission was achieved.

3.
J Glob Health ; 10(1): 010417, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32373333

RESUMO

Background: We conducted a meta-analysis to explore the relationship between exposure to air pollution and the risk of cognitive impairment of longitudinal cohort studies. Methods: PubMed, Web of Science and Wan Fang databases were searched for relevant articles of longitudinal cohort studies published between January 1950 and September 2019. The pooled relative ratio (RR) and 95% confidence interval (CI) were calculated using the random effect model. Results: Ten articles involving 519 247 cases among 12 523 553 participants were included in this meta-analysis. The pooled RR of cognitive impairment per 5 µg/m3 increments in exposure to particulate matter ≤2.5 µm (PM2.5) was 1.08 (95% CI = 1.03, 1.13; I2 = 82.2%; Pheterogeneity <0.001). No association was found between nitrogen dioxide/nitrogen oxide (NO2/NOx) and ozone (O3) and cognitive impairment. For PM2.5 exposure, in subgroup analysis, the above-mentioned significant positive association was found among studies conducted in population (RR p er 5 µg/m 3 = 1.05; 95% CI = 1.01,1.09; I2 = 57.4%; Pheterogeneity = 0.016), in North America (RR per 5 µg/m 3 = 1.13; 95% CI = 1.01,1.26; I2 = 86.7%; Pheterogeneity <0.001) and with follow-up duration >10 years (RR p er 5 µg/m 3 = 1.10; 95% CI = 1.03,1.17; I2 = 86.3%; Pheterogeneity <0.001). Conclusions: This meta-analysis suggests that exposure to PM2.5 might increase the risk of cognitive impairment.

4.
Acc Chem Res ; 53(6): 1111-1123, 2020 Jun 16.
Artigo em Inglês | MEDLINE | ID: mdl-32466638

RESUMO

ConspectusHydrogen is an ideal energy carrier and plays a critical role in the future energy transition. Distinct from steam reforming, electrochemical water splitting, especially powered by renewables, has been considered as a promising technique for scalable production of high-purity hydrogen with no carbon emission. Its commercialization relies on the reduction of electricity consumption and thus hydrogen cost, calling for highly efficient and cost-effective electrocatalysts with the capability of steadily working at high hydrogen output. This requires the electrocatalysts to feature (1) highly active intrinsic sites, (2) abundant accessible active sites, (3) effective electron and mass transfer, (4) high chemical and structural durability, and (5) low-cost and scalable synthesis. It should be noted that all these requirements should be fulfilled together for a practicable electrocatalyst. Much effort has been devoted to addressing one or a few aspects, especially improving the electrocatalytic activity by electronic modulation of active sites, while few reviews have focused on the synergistic modulation of these aspects together although it is essential for advanced electrochemical water splitting.In this Account, we will present recent innovative strategies with an emphasis on our solutions for synergistically modulating intrinsic active sites, electron transportation, mass transfer, and gas evolution, as well as mechanical and chemical durability, of non-precious-metal electrocatalysts, aiming for cost-effective and highly efficient water splitting. The following approaches for coupling these aspects are summarized for both cathodic hydrogen evolution reaction (HER) and anodic oxygen evolution reaction (OER). (1) Synergistic electronic modulations. The electronic structure of a catalytic site determines the adsorption/desorption of reactive intermediates and thus intrinsic activity. It can be tuned by heterogeneous doping, strain effect, spin polarization, etc. Coupling these effects to optimize the reaction pathways or target simultaneously the activity and stability would advance electrocatalytic performance. (2) Synergistic electronic and crystalline modulation. The crystallinity, crystalline phase, crystalline facets, crystalline defects, etc. affect both activity and stability. Coupling these effects with electronic modulation would enhance the activity together with stability. (3) Synergistic electronic and morphological modulation. It will focus on concurrently modulating electronic structure for improving the intrinsic activity and morphology for increasing accessible active sites, especially through single action or processing. The mass transfer and gas evolution properties can also be enhanced by morphological modulation to enable water splitting at large output. (4) Synergistic modulation of elementary reactions. Electrocatalytic reaction generally consists of a couple of elementary reactions. Each one may need a specific active site. Designing and combining various components targeting every elementary step on a space-limited catalyst surface will balance the intermediates and these steps for accelerating the overall reaction. (5) Integrated electrocatalyst design. Taking all these strategies together into account is necessary to integrate all above essential features into one electrocatalyst for enabling high-output water electrolysis. Beyond the progress made to date, the remaining challenges and opportunities is also discussed. With these insights, hopefully, this Account will shed light on the rational design of practical water-splitting electrocatalysts for the cost-effective and scalable production of hydrogen.

5.
Chem Commun (Camb) ; 2020 Apr 14.
Artigo em Inglês | MEDLINE | ID: mdl-32285080

RESUMO

Fe-doped Co3O4 polycrystalline nanosheets vertically grown on carbon cloth were developed as self-standing efficient bifunctional electrocatalysts for oxygen reduction and evolution, enabling high-performance Zn-air batteries with a power density of 268.6 mW cm-2 and superior cycling stability.

6.
Carbohydr Res ; 492: 107999, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32272238

RESUMO

Tumor-associated carbohydrate antigens Lewis X (Lex), Lewis Y (Ley), and KH-1 are useful targets for cancer immunotherapy. In this regard, an insight into the structure-immunogenicity relationships of these antigens is important but this has not been systematically investigated yet. In the current study, Lex, Ley, and KH-1 antigens with a lactose unit at the reducing end as a spacer were synthesized and coupled with keyhole limpet hemocyanin (KLH) protein. Immunological evaluations of the resultant conjugates revealed that they all could elicit robust immune responses whilst the Ley conjugate could provoke the highest titers of total and IgG antibodies. The binding assays of their antisera to each antigen and to cancer cells showed that each antiserum had extensive cross-reaction with all three antigens as protein conjugates and strong but somewhat antigen-selective binding towards MCF-7 cancer cell. Moreover, none of these antisera had obvious binding to SKMEL-28 cancer cell that does not express Lex, Ley and KH-1. The results of assays of these antisera to mediate complement-dependent cytotoxicity (CDC) to MCF-7 and SKMEL-28 cancer cells were very similar to the results of binding assays. Thus, it was concluded that all three antigens could form effective conjugate vaccines whereas the Ley conjugate induced the most robust immune responses and the antiserum of Lex had the highest binding and cytotoxicity to target cancer cells. In addition, as the antibodies induced by each antigen had extensive cross-reaction with other two antigens, either Lex or Ley or the two combined can be utilized to formulate effective conjugate vaccines for cancer immunotherapy. Another paradigm-shifting discovery of this study is that the presentation of Lex, Ley, and KH-1 antigens on cancer cell can be different from that in synthetic conjugates, which should be taken into consideration during the design and optimization of related cancer vaccines or immunotherapies.

7.
Small ; : e2001171, 2020 Apr 24.
Artigo em Inglês | MEDLINE | ID: mdl-32329197

RESUMO

Highly efficient and stable bifunctional electrocatalysts for oxygen reduction and evolution are essential for aqueous rechargeable Zn-air batteries, which require highly active sites as well as delicate structural design for increasing effective active sites and facilitating mass/electron transfer. Herein, a scalable and facile self-catalyzed growth strategy is developed to integrate highly active Co-N-C sites with 3D brush-like nanostructure, achieving Co-N-C nanobrushes with Co,N-codoped carbon nanotube branches grown on Co,N-codoped nanoparticle assembled nanowire backbones. Systematic investigations suggest that nanobrushes deliver significantly improved electrocatalytic activity compared with nanowire or nanotube counterparts and the longer nanotube branches give the better performance. Benefiting from the increase of accessible highly active sites and enhanced mass transfer and electron transportation, the present Co-N-C nanobrush exhibits superior electrocatalytic activity and durability when used as a bifunctional oxygen catalyst. It enables a rechargeable Zn-air battery with a high peak power density of 246 mW cm-2 and excellent cycling stability. These results suggest that the reported synthetic strategy may open up possibilities for exploring efficient electrocatalysts for diverse applications.

8.
Org Biomol Chem ; 18(15): 2938-2948, 2020 04 15.
Artigo em Inglês | MEDLINE | ID: mdl-32242600

RESUMO

Two myo-inositol derivatives having an Nα,Nε-diacetyl-l-lysine (Ac2Lys) moiety linked to the inositol 1-O-position through a self-cleavable linker and a metabolically stable 2-azidoethyl group linked to the inositol 3-O- and 4-O-positions, respectively, were designed and synthesized. The Ac2Lys moiety blocking the inositol 1-O-position required for GPI biosynthesis was expected to be removable by a combination of two enzymes, histone deacetylase (HDAC) and cathepsin L (CTSL), abundantly expressed in cancer cells, but not in normal cells, to transform these inositol derivatives into biosynthetically useful products with a free 1-O-position. As a result, it was found that these inositol derivatives could be incorporated into the glycosylphosphatidylinositol (GPI) biosynthetic pathway by cancer cells, but not by normal cells, to express azide-labeled GPIs and GPI-anchored proteins on cell surfaces. Consequently, this study has established a novel strategy and new molecular tools for selective metabolic labeling of cancer cells, which should be useful for various biological studies and applications.

9.
Surg Endosc ; 34(5): 1891-1903, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-32144555

RESUMO

BACKGROUND: Despite the fact that thyroid surgery has evolved towards minimal incisions and endoscopic approaches, the role of total endoscopic thyroidectomy (TET) in thyroid cancer has been highly disputed. We performed a systematic review and meta-analyses of peer reviewed studies in order to evaluate the safety and effectiveness of TET compared with conventional open thyroidectomy (COT) in papillary thyroid cancer (PTC). METHOD: Medical literature databases such as PubMed, Embase, the Cochrane Library, and Web of science were systematically searched for articles that compared TET and COT in PTC treatment from database inception until March 2019. The quality of the studies included in the review was evaluated using the Downs and Black scale using Review Manager software Stata V.13.0 for the meta-analysis. RESULTS: The systematic review and meta-analysis were based on 5664 cases selected from twenty publications. Criteria used to determine surgical completeness included postoperative thyroglobulin (TG) levels, recurrence of the tumor after long-term follow-up. Adverse event and complication rate scores included transient recurrent laryngeal nerve (RLN) palsy, permanent RLN palsy, transient hypocalcaemia, permanent hypocalcaemia, operative time, number of removed lymph nodes, length of hospital stay and patient cosmetic satisfaction. TET was found to be generally equivalent to COT in terms of surgical completeness and adverse event rate, although TET resulted in lower levels of transient hypocalcemia (OR 1.66; p < 0.05), a smaller number of the retrieved lymph nodes (WMD 0.46; p < 0.05), and better cosmetic satisfaction (WMD 1.73; p < 0.05). COT was associated with a shorter operation time (WMD - 50.28; p < 0.05) and lower rates of transient RLN palsy (OR 0.41; p < 0.05). CONCLUSIONS: The results show that in terms of safety and efficacy, TET was similar to COT for the treatment of thyroid cancer. Indeed, the tumor recurrence rates and the level of surgical completeness in TET are similar to those obtained for COT. TET was associated with significantly lower levels of transient hypocalcemia and better cosmetic satisfaction, and thus is the better option for patients with cosmetic concerns. Overall, randomized clinical trials and studies with larger patient cohorts and long-term follow-up data are required to further demonstrate the value of the TET.

10.
J Am Chem Soc ; 2020 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-32196325

RESUMO

Creating high-density durable bifunctional active sites in an air electrode is essential but still challenging for a long-life rechargeable zinc-air battery with appealing power density. Herein, we discover a general strategy mediated by metastable rock salt oxides for achieving high-density well-defined transition-metal nanocrystals encapsulated in N-doped carbon shells (M@NC) which are anchored on a substrate by a porous carbon network as highly active and durable bifunctional catalytic sites. Small-size (15 ± 5 nm) well-dispersed Co2Fe1@NC in a high density (metal loading up to 54.0 wt %) offers the zinc-air battery a record power density of 423.7 mW cm-2. The dual protection from the complete graphitic carbon shells and the anchoring of the outer carbon network make Co2Fe1@NC chemically and mechanically durable, giving the battery a long cycling life. Systematic in-situ temperature-dependent characterizations as well as DFT modeling rationalize the rock salt oxide-mediated process and its indispensable role in achieving high-density nanosized M@NC. These findings open up opportunities for designing efficient electrocatalysts for high-performance Zn-air batteries and diverse energy devices.

11.
Biomed Res Int ; 2020: 3783481, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32219131

RESUMO

Object. Results on the associations of fruit and vegetable intake with risk of chronic obstructive pulmonary disease (COPD) are still in conflict. Hence, we conducted a meta-analysis to quantitatively evaluate the association between fruit and vegetable intake and the risk of COPD. Methods: PubMed, Web of Science, and China National Knowledge Infrastructure (CNKI) were searched for relevant studies published up to September 2019. Combined relative risks (RRs) and 95% confidence intervals (CIs) were calculated with the random effects model (REM). Dose-response relationship was assessed by the restricted cubic spline model. Results: There are 8 studies involving 5,787 COPD cases among 244,154 participants included in this meta-analysis. For the highest versus the lowest level, the pooled RR of COPD was 0.75 (95% CI, 0.68-0.84; I 2 = 46.7%) for fruits plus vegetables, 0.72 (95% CI, 0.66-0.79; I 2 = 46.7%) for fruits plus vegetables, 0.72 (95% CI, 0.66-0.79; I 2 = 46.7%) for fruits plus vegetables, 0.72 (95% CI, 0.66-0.79; P non-linearity < 0.01). Conclusions: This meta-analysis indicates that fruit and vegetable intake might be related to a lower risk of COPD.

12.
Cells ; 9(2)2020 Feb 24.
Artigo em Inglês | MEDLINE | ID: mdl-32102444

RESUMO

Ubiquinone is an important cofactor that plays vital and diverse roles in many biological processes. Ubiquinone-binding proteins (UBPs) are receptor proteins that dock with ubiquinones. Analyzing and identifying UBPs via a computational approach will provide insights into the pathways associated with ubiquinones. In this work, we were the first to propose a UBPs predictor (UBPs-Pred). The optimal feature subset selected from three categories of sequence-derived features was fed into the extreme gradient boosting (XGBoost) classifier, and the parameters of XGBoost were tuned by multi-objective particle swarm optimization (MOPSO). The experimental results over the independent validation demonstrated considerable prediction performance with a Matthews correlation coefficient (MCC) of 0.517. After that, we analyzed the UBPs using bioinformatics methods, including the statistics of the binding domain motifs and protein distribution, as well as an enrichment analysis of the gene ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway.

13.
Adv Mater ; : e1906015, 2020 Feb 06.
Artigo em Inglês | MEDLINE | ID: mdl-32027058

RESUMO

Developing low-cost, highly efficient, and durable electrocatalysts for oxygen evolution reaction (OER) is essential for the practical application of electrochemical water splitting. Herein, it is discovered that organic small molecule (hexabromobenzene, HBB) can activate commercial transition metal (Ni, Fe, and NiFe) foam by directly evolving metal nanomeshes embedded in graphene-like films (M-NM@G) through a facile Br-induced solid-phase migration process. Systematic investigations indicate that HBB can conformally generate graphene-like network on bulk metal foam substrate via the cleavage of CBr bonds and the formation of CC linkage. Simultaneously, the cleaved CBr fragments can efficiently extract metal atoms from bulk substrate, in situ producing transition metal nanomeshes embedded in the graphene-like films. As a result, such functional nanostructure can serve as an efficient OER electrocatalyst with a low overpotential and excellent long-term stability. Specifically, the overpotential at 100 mA cm-2 is only 208 mV for NiFe-NM@G, ranking the top-tier OER electrocatalysts. This work demonstrates an intriguing general strategy for directly transforming bulk transition metals into nanostructured functional electrocatalysts via the interaction with organic small molecules, opening up opportunities for bridging the application of organic small molecules in energy technologies.

14.
J Assist Reprod Genet ; 37(3): 579-588, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-32103397

RESUMO

PURPOSE: To investigate the associations of previous pregnancy failures, including implantation failures (IFs), biochemical pregnancy losses (BPLs), and early (EMs) and late miscarriages (LMs), with blastocyst aneuploidy and pregnancy outcomes after PGT-A. METHODS: This study included 792 couples who underwent PGT-A after multiple pregnancy failures. Subgroup analyses were used to compare the blastocyst aneuploidy rate (BAR), implantation rate (IR), early miscarriage rate (EMR), and live birth rate (LBR). Multiple linear and logistic regression models were used to evaluate the associations. The control group comprised couples with ≤ 2 IFs, ≤ 1 BPL, ≤ 1 EM, and no LM. RESULTS: Notably, a history of ≥ 4 IFs was significantly associated with an increase in aneuploid blastocysts (42.86% vs. 33.05%, P = 0.044, B = 10.23 for 4 IFs; 48.80% vs. 33.05%, P = 0.002, B = 14.43 for ≥ 5 IFs). Women with ≥ 4 prior EMs also harbored more aneuploid blastocysts (41.00% vs. 33.05%, P = 0.048; B = 9.23). Compared with the control group, women with ≥ 4 prior EMs had a significantly higher EMR (6.58% vs. 31.11%, P < 0.001, OR = 6.49) and a lower LBR (53.49% vs. 34.18%, P = 0.007, OR = 0.56) after euploid transfer. Moreover, a history of LM(s) was associated with adverse pregnancy outcomes after PGT-A (OR for EM = 3.16; OR for live birth = 0.48). However, previous BPLs and 2 EMs were not associated significantly with blastocyst aneuploidy and pregnancy outcomes after PGT-A. CONCLUSION: A history of high-order IFs or EMs and existence of LM(s) were significantly associated with blastocyst aneuploidy and adverse pregnancy outcomes after PGT-A, whereas no such associations were observed with BPLs or 2 EMs.

15.
Toxicon ; 176: 15-20, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31965969

RESUMO

Podophyllotoxin (PPT) is a lignan extracted from podophyllum genera and it shows potent antitumor activity since it could effectively inhibit the assembly of microtubule in tumor cells. However, the effects of podophyllotoxin exposure on porcine oocyte quality is still unclear. In present study we tried to examine whether podophyllotoxin exposure was toxic to porcine oocyte maturation. Our results showed that podophyllotoxin exposure inhibited porcine oocyte maturation, showing with the failure of polar body extrusion, and the inhibitory effects of podophyllotoxin on porcine oocytes was dose-depended. Moreover, the meiotic spindle formation was disturbed and the chromosomes were misaligned in the podophyllotoxin-treated porcine oocytes. However, there was no different expression for p-MAPK and ace-tubulin between the control and podophyllotoxin treatment group. In addition, after 0.01 µM podophyllotoxin treatment, the intracellular reactive oxygen species (ROS) levels and the Annexin-V signal at MI stage significantly increased compared to the control group, indicating the occurrence of oxidative stress and early apoptosis. Taken together, our results suggested that the toxic effects of podophyllotoxin exposure on porcine oocyte maturation might be through its effects on spindle formation and the induction of oxidative stress-mediated early apoptosis.


Assuntos
Antineoplásicos Fitogênicos/toxicidade , Oócitos/efeitos dos fármacos , Estresse Oxidativo/fisiologia , Podofilotoxina/toxicidade , Animais , Apoptose , Ciclo Celular , Espécies Reativas de Oxigênio , Suínos
16.
Theriogenology ; 143: 64-73, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31837632

RESUMO

Aging oocytes undergo various molecular, cellular, and biochemical changes. Aging of oocytes results in reduced embryo developmental capacity and blastocyst quality, which is thought to be caused partly by the accumulation of reactive oxygen species (ROS). This study aimed to determine the effect of l-carnitine (LC) on the development of embryos formed from aged oocytes in vitro. The development and quality of the blastocysts in the LC-treated group were significantly higher than those in the untreated aged group after in vitro fertilization (IVF). In addition, after LC treatment, the level of intracellular ROS in aged group significantly decreased, and glutathione (GSH) levels significantly increased compared with those in the untreated aged group. There was no significant difference in the mitochondrial membrane potential among the three groups. Moreover, ROS could induce autophagy and LC3 antibody was widely used as a marker for detecting autophagy. The fluorescence intensity of LC3 in the aged group was significantly higher than that of LC3 in the LC-treated group. Furthermore, Real-time reverse transcriptase-polymerase chain reaction showed that the mRNA levels of antioxidation genes GPX4 and SOD1 were significantly higher in embryos from LC-treated group than in those from the untreated aged group. In summary, our results indicated that LC can improve the developmental capacity of embryos from aging oocytes in vitro by reducing oxidative stress.

17.
Lab Invest ; 100(4): 619-629, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-31748682

RESUMO

Tumor-associated macrophages (TAMs) constitute a large population of glioblastoma and facilitate tumor growth and invasion of tumor cells, but the underlying mechanism remains undefined. In this study, we demonstrate that chemokine (C-C motif) ligand 8 (CCL8) is highly expressed by TAMs and contributes to pseudopodia formation by GBM cells. The presence of CCL8 in the glioma microenvironment promotes progression of tumor cells. Moreover, CCL8 induces invasion and stem-like traits of GBM cells, and CCR1 and CCR5 are the main receptors that mediate CCL8-induced biological behavior. Finally, CCL8 dramatically activates ERK1/2 phosphorylation in GBM cells, and blocking TAM-secreted CCL8 by neutralized antibody significantly decreases invasion of glioma cells. Taken together, our data reveal that CCL8 is a TAM-associated factor to mediate invasion and stemness of GBM, and targeting CCL8 may provide an insight strategy for GBM treatment.

18.
Nanoscale ; 12(2): 524-529, 2020 Jan 02.
Artigo em Inglês | MEDLINE | ID: mdl-31845941

RESUMO

Carbon dots (C-dots) are promising and widely applied carbon fluorescent materials for next-generation white light-emitting diodes (WLEDs). However, nonnegligible thermal quenching issues induced by high working temperature of high-power WLEDs severely limit the further development of C-dot phosphors. In this paper, we report an efficient strategy to improve thermal dissipation within C-dot phosphors to solve the thermal quenching problem. C-dots/hexagonal boron nitride nanosheet (BNNS) hybrid nanostructures have been firstly prepared through an electrostatic assembly method. Owing to the effective heat transfer channels established by C-dots/BNNS in a polymer matrix, heat could be dissipated efficiently and the working temperature of WLEDs is reduced by 29 °C, suggesting excellent thermal quenching-resistance properties. Particularly, the hybrids show thermally stable emission without obvious emission loss up to 100 °C. Moreover, the C-dots/BNNS-WLEDs still maintain a high color rendering index of Ra > 89, revealing that the present strategy could promote the exploration of carbon phosphors with thermal quenching resistance for high-quality LED applications.

19.
J Cosmet Dermatol ; 2019 Dec 09.
Artigo em Inglês | MEDLINE | ID: mdl-31820550

RESUMO

BACKGROUND: Clinical outcomes of eyebrow restoration with single-follicular-unit hair transplantation largely depend on the surgeon's anatomic knowledge, experience, and technical skills. AIMS: To evaluate the effect of the reconstruction with single follicular unit transplantation on eyebrow loss and provide technical tips. PATIENTS AND METHODS: A total of 352 patients with eyebrow loss were recruited. A template of the restoration region was modeled or specifically designed. The scalp strips from the back occipital or retro-auricular regions were harvested for single follicular unit hair. The follicles were transplanted by punching recipient area with 21-G syringe needle. Patients were followed up every 2 months for 4 years after surgery. RESULTS: Out of 352, 320 (91%) patients had their transplanted hair grow well with satisfactory direction and appearance. Seventeen patients (5%) experienced encryption transplantation of a sparse hair for the first 6 months but felt satisfied afterward. Twelve (3%) patients did a simple make-up on the transplanted hair because there was an obvious difference between the transplanted hair and the natural one. Three (1%) patients with burned injury suffered of mild folliculitis and cured by 75% alcohol inunction. All patients had no obvious scar at the donor sites. CONCLUSION: Single follicular transplantation for eyebrow loss resulted in natural restorations with excellent satisfaction. The technique is simple, safe, and effective. The usage of syringe needle, microscope slide forceps, and a magnifier could implant the hair in a right angle, desired direction and depth, and increase the survival rate.

20.
J Org Chem ; 84(21): 13232-13241, 2019 11 01.
Artigo em Inglês | MEDLINE | ID: mdl-31565939

RESUMO

Analogues of cancer-associated Lewis Y (Ley) antigen with varying structures at the reducing end were synthesized by a highly efficient strategy involving one-pot preactivation-based iterative glycosylation to obtain the key tetra-/pentasaccharide intermediates, which was followed by stereoselective fucosylation. After global deprotection, these oligosaccharides were coupled with carrier protein keyhole limpet hemocyanin. The resultant glycan-protein conjugates were subjected to immunological studies in mice. It was disclosed that the conjugate of the pentasaccharide analogue of Lewis Y antigen was more immunogenic than that of the hexasaccharide analogue, but the antisera of both conjugates could indiscriminately recognize each carbohydrate hapten. These results suggested that the short Lewis Y analogue may be utilized to develop functional conjugate cancer vaccines. More importantly, the results also proved that the reducing-end glucose residue in the hexasaccharide analogue of Lewis Y was probably not involved in its interaction with the immune system, whose discovery can have a broad impact on the design of new cancer vaccines.

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