Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 47
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Front Psychol ; 13: 811617, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35432142

RESUMO

Using data from the China Education Panel Survey (CEPS), which was a nationally representative sample of junior high school students, this study examined the association of internal migration with depression among migrant and left-behind children, while exploring the moderating effect of gender difference and the mediating effects of social relationships. The results showed that migrant children had a significantly lower level of depression than left-behind children. Further, the difference in mental health between migrant children and left-behind children was more prominent for boys than girls. The mechanism analyses indicated that compared to left-behind children, internal migration positively predicted parent-child relationships and peer relationships of migrant children, which in turn reduced their depressive symptoms. Although migrant children suffered from a higher level of teacher discrimination than their left-behind counterparts, it had no significant relationship with depression after controlling for children's social relationships with parents and peers. Our findings suggested that migrating with parents was helpful to reduce children's depressive symptoms in comparison with being left behind. Therefore, actions should be implemented to reduce the occurrence of involuntary parent-child separation and the prevalence of children's depressive disorders due to institutional constraints. In addition, necessary treatments are needed to improve the psychological wellbeing of disadvantaged children, especially among left-behind children with mental illness.

2.
J Crohns Colitis ; 2022 Apr 07.
Artigo em Inglês | MEDLINE | ID: mdl-35390137

RESUMO

BACKGROUND AND AIMS: Intestinal ultrasound (IUS) has been increasingly reported to distinguish inflammatory or fibrotic intestinal stenosis in Crohn's disease (CD) patients. However, the diagnostic value is unclear. This systematic review and meta-analysis aimed to assess the diagnostic role of different modes of IUS parameters. METHODS: We searched PubMed, Embase, Web of Science, and Cochrane Library from inception to August 2021. Regarding effect sizes, weighted mean differences (WMDs) or standardized mean differences (SMDs) were used. We pooled data using a random-effects or fixed-effects model according to heterogeneity. The diagnostic accuracy of IUS for distinguishing fibrosis was pooled. RESULTS: 19 studies were retained for qualitative analysis, and 14 were included in the meta-analysis (with 511 total subjects and 635 bowel segments). In patients with fibrotic stenosis, the pooled WMDs for bowel wall thickness were 1.30 mm (95% CI 0.69-1.91) thicker than patients with inflammatory stenosis, and the pooled SMDs for strain value and strain ratio were 0.80 (95 % CI 0.41-1.20) and 1.08 (95 % CI 0.55-1.60) harder than patients with inflammatory stenosis, respectively. The percentage of maximal enhancement of fibrotic stenosis was lower than that of inflammatory stenosis (WMD -10.03, 95% CI -17.91- -2.16). The diagnostic accuracy of IUS was not performed because only a few studies provided relevant diagnostic indicators, and these studies used different modes and parameters. CONCLUSIONS: IUS currently is inaccurate to differentiate fibrotic or inflammatory stenosis in CD patients, and more studies assessing the significance of each parameter and its cut-off value in different modes of IUS are needed to be conducted in the future.

3.
J Arthroplasty ; 37(5): 888-891, 2022 May.
Artigo em Inglês | MEDLINE | ID: mdl-35031417

RESUMO

BACKGROUND: This study aimed to evaluate the effect of perioperative dexamethasone on acute phase response (APR) after simultaneous bilateral total hip arthroplasty (SimBTHA). METHODS: A retrospective case-control study was performed on 177 SimBTHA procedures. The patients were divided into 2 cohorts: patients receiving perioperative dexamethasone and patients in whom no dexamethasone was administered. We observed the effects of perioperative dexamethasone on the APR following SimBTHA by trending C-reactive protein and interleukin-6. Besides, the incidence of postoperative nausea and vomiting (PONV), postoperative visual analog scale (VAS) score, use of antiemetic and analgesic rescue, and complications were also compared. RESULTS: Compared to the no dexamethasone group, patients receiving dexamethasone yielded a significantly decreased C-reactive protein on postoperative days 1, 2 and 3. Such differences of interleukin-6 were also detected. In addition, the incidence of PONV, postoperative VAS score, and use of antiemetic and analgesic rescue were significantly decreased without increasing the risk of early surgical wound infection and gastrointestinal hemorrhage in patients receiving dexamethasone. CONCLUSION: The anti-inflammatory effects of dexamethasone can attenuate the APR after SimBTHA as well as decrease the PONV, postoperative VAS score, and use of antiemetic and analgesic rescue.


Assuntos
Antieméticos , Artroplastia de Quadril , Reação de Fase Aguda , Analgésicos , Antieméticos/uso terapêutico , Artroplastia de Quadril/efeitos adversos , Proteína C-Reativa/análise , Estudos de Casos e Controles , Dexametasona/uso terapêutico , Método Duplo-Cego , Humanos , Interleucina-6 , Dor Pós-Operatória/tratamento farmacológico , Dor Pós-Operatória/prevenção & controle , Náusea e Vômito Pós-Operatórios/epidemiologia , Náusea e Vômito Pós-Operatórios/prevenção & controle , Estudos Retrospectivos
4.
Rev Sci Instrum ; 92(11): 114103, 2021 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-34852530

RESUMO

A dispersive atomic fluorescence spectrometer based on a UV digital micromirror device (UV-DMD-AFS) has been proposed by our team for attenuating spectral and scattering interferences. Software is nontrivial for the automation of component control and sample analysis in the new instrument. In this work, the software was developed using the C# programming language together with multi-threading and combined with the SQLite database, which consists of component control and data acquisition, database, wavelength initialization, and real-time interference reduction module. To realize the accurate analysis of the trace heavy metal concentration, the spectral interference was avoided by measuring the non-interference wavelength, and the scattering interference was eliminated by the real-time proportional coefficient method. The microsecond rotation speed of the DMD is the key to achieving real-time reduction. The concentration of arsenic in Water Quality (GSB 07-3171-2014) was detected to validate the practicability of the software with the concentration deviation of 0.02 ng/mL.

5.
Appl Opt ; 60(29): 9101-9109, 2021 Oct 10.
Artigo em Inglês | MEDLINE | ID: mdl-34623992

RESUMO

For an echelle spectrometer based on a digital micromirror device and photomultiplier, a lens group is placed in front of the digital micromirror device and used to converge the two-dimensional spectrum and correct aberration. The matching spectral reduction model is deduced by establishing the mathematical models of the imaging mirror and lens group. According to the known wavelength and corresponding coordinates, the refractive index of the prism is fitted, and the spectrum is divided into three parts to calibrate. Experimental results of a mercury lamp show that the maximum deviations of x and y coordinates are 3.4 pixels and 2.3 pixels in the corrected spectral reduction model. The deviations are in the range of the errors permitted, which means the extraction of order and wavelength satisfy the requirement of the spectrometer.

6.
Nanoscale ; 13(17): 8004-8011, 2021 May 07.
Artigo em Inglês | MEDLINE | ID: mdl-33956919

RESUMO

Mass production of semiconductor quantum dots (QDs) from bulk materials is highly desired but far from being satisfactory. Herein, we report a general strategy to mechanically tailor semiconductor bulk materials into QDs. Semiconductor bulk materials are routinely available via simple chemical precipitation. From their bulk materials, a variety of semiconductor (e.g., lead sulfide (PbS), cadmium sulfide (CdS), copper sulfide (CuS), ferrous sulfide (FeS), and zinc sulfide (ZnS)) QDs are successfully produced in high yields (>15 wt%). This is achieved by a combination of silica-assisted ball-milling and sonication-assisted solvent treatment. The as-produced QDs show intrinsic characteristics and outstanding water solubility (up to 5 mg mL-1), facilitating their practical applications. The QD dispersions present remarkable photoluminescence (PL) with exciton-dependence and nanosecond (ns)-scale lifetimes. The QDs-poly(methyl methacrylate) (PMMA) hybrid thin films demonstrate exciting solid-state fluorescence and exceptional nonlinear saturation absorption (NSA). Absolute modulation depths of up to 58% and saturation intensities down to 0.40 MW cm-2 were obtained. Our strategy could be applied to any semiconductor bulk materials and therefore paves the way for the construction of the complete library of semiconductor QDs.

7.
Environ Toxicol ; 36(7): 1303-1315, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-33720505

RESUMO

Tributyltin (TBT) is a persistent organotin pollutant widely used as agricultural and wood biocides, exhibiting well-documented toxicity to reproductive functions in aquatic organisms. However, the effect of TBT on early pregnancy and placental development has been rarely studied in mice. Pregnant mice were fed with 0, 0.2, and 2 mg/kg/day TBT from gravid day 1 to day 8 or 13. TBT exposure led to an increase in the number of resorbed embryo and a reduction in the weight of fetus at gestational days 13. Further study showed that TBT significantly decreased placental weight and area, lowered laminin immunoreactivity and the expressions of placental development-related molecules including Fra1, Eomes, Hand1, and Ascl2. Moreover, TBT treatment markedly inhibited the placental proliferation and induced up-regulation of p53 and cleaved caspase-3 proteins, and down-regulation of Bcl-2 protein. In addition, TBT administration increased levels of malondialdehyde and H2 O2 and decreased activities of catalase and superoxide dismutase. Collectively, these results suggested TBT-induced adverse pregnancy outcomes during early pregnancy might be involved in developmental disorders of the placenta via dysregulation of key molecules, proliferation, apoptosis, and oxidative stress.


Assuntos
Placentação , Compostos de Trialquitina , Animais , Fatores de Transcrição Hélice-Alça-Hélice Básicos , Feminino , Humanos , Exposição Materna/efeitos adversos , Camundongos , Placenta , Gravidez , Resultado da Gravidez , Compostos de Trialquitina/toxicidade
8.
Phys Rev Lett ; 126(6): 063201, 2021 Feb 12.
Artigo em Inglês | MEDLINE | ID: mdl-33635700

RESUMO

The dissociative above-threshold double ionization (ATDI) of H_{2} in strong laser fields involves the sequential releasing of two electrons at specific instants with the stretching of the molecular bond. By mapping the releasing instants of two electrons to their emission directions in a multicycle polarization-skewed femtosecond laser pulse, we experimentally clock the dissociative ATDI of H_{2} via distinct photon-number-resolved pathways, which are distinguished in the kinetic energy release spectrum of two protons measured in coincidence. The timings of the experimentally resolved dissociative ATDI pathways are in good accordance with the classical predictions. Our results verify the multiphoton scenario of the dissociative ATDI of H_{2} in both time and energy fashion, strengthening the understanding of the strong-field phenomenon and providing a robust tool with a subcycle time resolution to clock abundant ultrafast dynamics of molecules.

9.
ACS Nano ; 15(1): 1291-1300, 2021 Jan 26.
Artigo em Inglês | MEDLINE | ID: mdl-33373181

RESUMO

Second-harmonic generation (SHG) in plasmonic nanostructures has been investigated for decades due to their wide applications in photonic circuit, quantum optics and biosensing. Development of large-scale, uniform, and efficient plasmonic nanostructure system with tunable modes is desirable for their feasible utilizations. Herein, we design an efficient inch-scale SHG source by a solution-processed method instead of traditional high-cost processes. By assembling the gold nanoparticles with the porous anodic alumina templates, multiresonance in both visible and near-infrared regions can be achieved in hexagonal plasmonic nanostructure arrays, which provide strong electric field enhancement at the gap region. Polarization-independence SHG radiation has been realized owing to the in-plane isotropic characteristic of assembled unit. The tilt-angle dependent and angle-resolved measurement showed that wide-angle nonlinear response is achieved in our device because of the gap geometry of ball-in-bowl nanostructure with nonlinear emission electric dipoles distributed on the concave surface, which makes it competitive in practical applications. Our progress not only makes it possible to produce uniform inch-scale nonlinear arrays through low-cost solution process; and also advances the understanding of the SHG radiation in plasmonic nanostructures.

10.
Langmuir ; 36(46): 13752-13758, 2020 Nov 24.
Artigo em Inglês | MEDLINE | ID: mdl-33175529

RESUMO

The edge doping effect would help improve the carbon-based electrocatalysis. Herein, we present an all-mechanical technique for the fabrication of cut, exfoliated N-doped carbon nanotubes (C, E-N-CNTs). Such nanohybrids with an edge-N-rich structure are obtained through sequential doping and mechanical treatments of the pristine bulk-CNTs. The C, E-N-CNT/carbon black (C, E-N-CNT/C) demonstrates exciting oxygen reduction reaction (ORR) electrocatalysis with exceptionally low-onset potential (E0, 913 mV versus RHE) and satisfactory half-wave potential (E1/2, merely -7.3 mV shift compared with that of commercial 20% platinum/C (Pt/C)). Besides, the C, E-N-CNT/C presents significantly enhanced durability and tolerance in chronoamperometry test with methanol injection compared with the Pt/C. Our work would facilitate the mass production and full exploration of nonmetallic electrocatalysts.

11.
ACS Appl Mater Interfaces ; 12(42): 47784-47791, 2020 Oct 21.
Artigo em Inglês | MEDLINE | ID: mdl-32985171

RESUMO

Transformation of carbon nanotubes (CNTs) into sub-10 nm pieces is highly required but remains a great challenge. Herein, we report a robust strategy capable of mechanically tailoring pristine multi-walled carbon nanotubes (MWCNTs) into graphene quantum sheets (M-GQSs) with an extremely high yield of up to 44.6 wt %. The method combines silica-assisted ball-milling and sonication-assisted solvent exfoliation and therefore enables reproducible high-yield production of M-GQSs directly from MWCNTs. Remarkable solvent diversity and extraordinary solvability (up to 7 mg/mL) are demonstrated facilitating the solution processing of the M-GQSs. The M-GQSs are essentially monolayers with intrinsic curvature, which could be determinative to their outstanding performances in both dispersions and thin films. Besides the excitation wavelength-, concentration-, and solvent-dependent photoluminescence in dispersions, the solid-state fluorescence and exceptional nonlinear saturation absorption (NSA) in thin films are demonstrated. Particularly, NSA with relative modulation depth up to 46% and saturation intensity down to 1.53 MW/cm2 are achieved in M-GQS/poly(methyl methacrylate) hybrid thin films with a loading content of merely 0.2 wt %. Our method opens up a new avenue toward conversion and utilization of CNTs.

12.
Front Neurol ; 11: 625, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32793090

RESUMO

Background: Cognitive impairments in temporal lobe epilepsy (TLE) patients has been described as a chronically progressive feature of the disease. However, how severe recurrent seizures modify neuronal circuits in the human brain and subsequently degrade cognitive function, remains largely unknown. Here, we aimed to investigate longitudinal alterations by functional magnetic resonance imaging (fMRI) in TLE patients and to assess how those alterations are related to cognitive function performance. Methods: Sixteen TLE patients and 20 normal controls (NCs) were recruited for a study to observe longitudinal alterations in resting-state functional connectivity (FC) and to estimate alertness, orientation, and executive function both at baseline and at a follow-up time ~3 years later. Results: TLE patients, compared with NCs, showed impaired executive function, intrinsic alertness, and phasic alertness and exhibited lengthened reaction time (RT) in the spatial cue and center cue conditions at baseline. The orienting function of TLE patients was declined at follow-up compared to the baseline. Cross-sectional analysis demonstrated that TLE patients displayed significantly greater positive correlation than NCs between the right dorsolateral prefrontal cortex (DLPFC) and the right inferior parietal lobule (IPL) and right superior frontal gyrus (SFG). Furthermore, among TLE patients, the longitudinal study revealed a decrease in correlation between the right DLPFC and the right SFG compared to the baseline. In addition, there was a significant negative correlation between the longitudinal change in FC and the change in orienting function in TLE subjects. Conclusions: Abnormal connectivity between the DLPFC and the SFG suggests the potential of longitudinal resting-state fMRI to delineate regions relevant to cognitive dysfunction for disease progression.

13.
Materials (Basel) ; 13(9)2020 May 08.
Artigo em Inglês | MEDLINE | ID: mdl-32397170

RESUMO

In order to ensure the safety of traffic, asphalt pavement is commonly required to utilize aggregates with excellent anti-abrasion property. This results in the lack of high-quality aggregates. The incorporation of solid waste in the aggregates is regarded as a high potential alternative for solving this problem. Since its material properties, such as rough surface, high Polished Stone Value (PSV) and the excellent adhesion property of asphalt, Basic Oxygen Furnace (BOF) slag can effectively improve the skid resistance of asphalt mixtures. First, the material properties of BOF slag are reviewed in this study. Then, the skid resistance of asphalt mixtures and aggregates are commendably evaluated by the Polished Stone Value test, Wehner/Schulze Tester, Aachen Polishing Machine, British Pendulum Test and Sand Patch test. The physical and mechanical properties of BOF slag play a key role in asphalt mixtures. This review found that the skid resistance mechanism of the BOF slag asphalt mixture is governed by factors such as BOF slag properties, incorporation methods and gradation types. Finally, the economic and environmental benefits of BOF slag asphalt mixtures were discussed. In addition, the function of gas catalysis and the melting of ice and snow can be added to the BOF slag asphalt mixture for a cleaner development in engineering. Furthermore, the existing problems, research directions and corresponding measures in this field are directed towards more durable and functional asphalt pavement construction.

14.
Front Physiol ; 11: 51, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32116763

RESUMO

Perfluorooctanoic acid (PFOA) is a widely used perfluorinated compound and known to cause developmental toxicity which includes the increase of resorbed embryo, decrease of fetal survival, and fetal growth retardation. Nevertheless, whether it is associated with alteration of placental development remains unknown. Pregnant mice were gavaged with 0, 2.5, 5, 10 mg PFOA /kg/day from pregnancy day (PD) 1 to PD 13. Results showed that PFOA exposure markedly decreased the placental weight and caused interstitial edema of placenta. Laminin staining indicated that blood sinusoids area was shrunken in placenta of PFOA-exposed mice. Furthermore, PFOA treatment significantly reduced numbers of uNK cells. Western blot analysis revealed that levels of Bax and cleaved-caspase 3 proteins were markedly up-regulated in PFOA-treated groups. In addition, TEM examination showed that PFOA treatment caused rupture of nuclear membrane and nuclear pyknosis and fragmentation. Thus, our results suggested that gestational PFOA exposure significantly inhibited development of early placenta through shrinkage of labyrinth vessels and downregulation of uNK cells and apoptosis induction, which may result in adverse gestational outcomes.

15.
J Hazard Mater ; 388: 121785, 2020 04 15.
Artigo em Inglês | MEDLINE | ID: mdl-31818667

RESUMO

Acrylamide (ACR), a neurotoxicity and carcinogenic chemical, has attracted considerable attention since it is present at high concentrations in thermally cooked carbohydrate-rich foods. ACR exposure significantly increased rate of fetal resorption, and decreased fetal body weights in mice. However, no detailed information is available about the effect of ACR on uterine decidualization, which is a vital process in the establishment of successful pregnancy. Thus, our aim of this study was to explore the effect and mechanism of ACR on uterine decidualization in vivo during mice pregnancy. Mice were gavaged with 0, 10, and 50 mg ACR /kg/day from gestational days (GD) 1 until GD 8, whereas pseudopregnant mice from pseudopregnant day (PPD) 4 until PPD 8. Results indicated ACR treatment dramatically reduced numbers of implanted embryos, and decreased the weights of implantation site and oil-induced uterus. Nevertheless, no significant difference was observed in the weights of no oil-induced uterus between control and ACR-treated group. Furthermore, ACR significantly reduced numbers of polyploidy and PCNA-positive decidual cells and expression of cyclin D3 and p21 proteins, and induced apoptosis of decidua, as presented by up-regulation of Bax and cleaved-caspase-3, and decreased Bcl-2 protein during normal pregnant and pseudopregnant process. In summary, ACR exposure significantly inhibited uterine endometrial decidualization via the apoptosis and suppression of cyclin D3/p21 in mice.


Assuntos
Acrilamida/toxicidade , Ciclina D3/metabolismo , Inibidor de Quinase Dependente de Ciclina p21/metabolismo , Útero/efeitos dos fármacos , Animais , Apoptose/efeitos dos fármacos , Regulação para Baixo , Implantação do Embrião , Feminino , Camundongos , Gravidez , Útero/crescimento & desenvolvimento , Útero/metabolismo
16.
Materials (Basel) ; 12(22)2019 Nov 17.
Artigo em Inglês | MEDLINE | ID: mdl-31744220

RESUMO

The performance of an asphalt mixture will deteriorate under the condition of salt erosion, but there are different opinions on the mechanism of deterioration. Few studies have focused on the relation between the change of void characteristics and performance deterioration of an asphalt mixture exposed to salt erosion. To explore the relation between the air voids characteristics of an asphalt mixture and mechanical damage under salt erosion, the mechanical damage in an asphalt mixture was measured by splitting strength. The asphalt mixture specimens, immersion solutions, asphalt mortar, and aggregate were scanned with CT technology. To segment the voids, the Otsu method was used over asphalt mortar and solution range of CT values. A three-dimensional reconstruction of the CT image was performed with Mimics 20 software to calculate the asphalt mixture's void characteristics. On this basis, the relationships between the change in void characteristics and splitting strength were analyzed. The results showed that the ideal calculated void fraction can be obtained by threshold segmentation of the image void/asphalt mortar interface with the local CT value Otsu method. Under the salt corrosion environment, the increase of open voids of an asphalt mixture is linearly correlated with the decrease of splitting strength, while salts' crystallization in the open voids produces crystallization pressure, accelerating the volume growth of open voids. The early damage of an asphalt mixture suffered from the salt may be mainly physical damage. These results can provide a useful reference for the performance of damage research on asphalt mixtures in salt enrichment areas.

17.
Brain Behav ; 9(11): e01446, 2019 11.
Artigo em Inglês | MEDLINE | ID: mdl-31605452

RESUMO

BACKGROUND: To date, no functional MRI (fMRI) studies have focused on brain entropy in right temporal lobe epilepsy (rTLE) patients. Here, we characterized brain entropy (BEN) alterations in patients with rTLE using resting-state functional MRI(rs-fMRI) and explored the relationship between BEN and alertness. METHOD: Thirty-one rTLE patients and 33 controls underwent MRI scanning to investigate differences in BEN and resting-state functional connectivity (rs-FC) in regions of interest (ROIs) between patients and controls. Correlation analyses were performed to examine relationships between the BEN of each ROI and alertness reaction times (RTs) in rTLE patients. RESULTS: Compared with controls, the BEN of rTLE patients was significantly increased in the right middle temporal gyrus, inferior temporal gyrus, and other regions of the left hemisphere and significantly decreased in the right middle frontal gyrus and left supplementary motor area (p < .05). The rs-FCs between the ROIs (at p < .01, with the left superior parietal lobule and right precentral gyrus defined as ROI1 and ROI2, respectively) and the whole brain showed an increasing trend in rTLE patients. In addition, the BEN of ROI2 was associated with the intrinsic alertness and phasic alertness RTs of patients with rTLE. CONCLUSIONS: Our findings suggest that BEN is altered in patients with rTLE and that decreased BEN in the right precentral gyrus is positively related to intrinsic and phasic alertness; the abnormal FC in the brain regions with altered entropy suggests a reconstruction of brain functional connectivity. These findings suggest that BEN mapping may provide a useful tool for probing brain mechanisms related to TLE.


Assuntos
Nível de Alerta/fisiologia , Atenção/fisiologia , Encéfalo/fisiopatologia , Epilepsia do Lobo Temporal/fisiopatologia , Adulto , Encéfalo/diagnóstico por imagem , Mapeamento Encefálico , Estudos de Casos e Controles , Entropia , Epilepsia do Lobo Temporal/diagnóstico por imagem , Feminino , Neuroimagem Funcional , Humanos , Imageamento por Ressonância Magnética , Masculino , Córtex Motor/diagnóstico por imagem , Córtex Motor/fisiopatologia , Lobo Parietal/diagnóstico por imagem , Lobo Parietal/fisiopatologia , Córtex Pré-Frontal/diagnóstico por imagem , Córtex Pré-Frontal/fisiopatologia , Tempo de Reação , Descanso , Lobo Temporal/fisiopatologia , Adulto Jovem
18.
Reprod Biol Endocrinol ; 17(1): 65, 2019 Aug 09.
Artigo em Inglês | MEDLINE | ID: mdl-31399145

RESUMO

Kisspeptin and its G protein-coupled receptor KISS1R play key roles in mammalian reproduction due to their involvement in the onset of puberty and control of the hypothalamic-pituitary-gonadal axis. However, recent studies have indicated a potential role of extra-hypothalamic kisspeptin in reproductive function. Here, we summarize recent advances in our understanding of the physiological significance of kisspeptin/KISS1R in the peripheral reproductive system (including the ovary, testis, uterus, and placenta) and the potential role of kisspeptin/KISS1R in reproductive diseases. A comprehensive understanding of the expression, function, and potential molecular mechanisms of kisspeptin/KISS1R in the peripheral reproductive system will contribute to the diagnosis, treatment and prevention of reproductive diseases.


Assuntos
Kisspeptinas/fisiologia , Receptores de Kisspeptina-1/fisiologia , Animais , Feminino , Kisspeptinas/genética , Kisspeptinas/metabolismo , Masculino , Oócitos/crescimento & desenvolvimento , Ovário/crescimento & desenvolvimento , Ovário/metabolismo , Ovulação , Placenta/metabolismo , Placenta/fisiologia , Gravidez , Receptores de Kisspeptina-1/genética , Receptores de Kisspeptina-1/metabolismo , Espermatogênese , Testículo/metabolismo , Útero/metabolismo
19.
ACS Appl Mater Interfaces ; 11(26): 23773-23779, 2019 Jul 03.
Artigo em Inglês | MEDLINE | ID: mdl-31187616

RESUMO

Controlled placement of nanoscale particles with nanometer precision on substrates/surfaces is highly desired toward functional nanodevices. Herein, we report the robust assembly of colloidal nanoparticles onto nanostructured aluminum surfaces. The surfaces are configured by porous anodic alumina (PAA) membranes on top of textured aluminum substrates. Capillary force and geometry confinement enable rapid and precise transfer of colloidal nanoparticles from solutions into PAA templates. Such top-down control of bottom-up assembly demonstrates large-area (>1 × 1 cm2) integration of nanoscale particles with exceedingly high yield (>95%) and exceptionally high density (>1010 particles/cm2). The plasmonic coupling between gold nanoparticles and aluminum surfaces, as well as between adjacent nanoparticles, is responsible for the unique reflectance from the assembled surfaces. The reflectance minimum (resonant absorption) can be readily shifted from visible to near-infrared by simple structural variation. The apparent surface colors are thus broadly manipulated. Our work offers a straightforward platform toward construction of surfaces with controlled reflectance.

20.
Behav Brain Res ; 372: 111950, 2019 10 17.
Artigo em Inglês | MEDLINE | ID: mdl-31103752

RESUMO

Astrocytic connexin dysfunction is closely associated with synaptic impairment and contributes to the pathological development of depressive-like behaviours. However, little is known about the expression of connexins in astrocytes from different brain regions, or how tissue specific connexin expression affects local neuronal activity. Here, we established a mouse model of chronic social defeated stress (CSDS), from which we isolated astrocytes from the medial prefrontal cortex (mPFC), hippocampus, amygdala, and ventral tegmental area (VTA). Expression profiling was then performed for connexins Cx26, Cx30, and Cx43. Expression of Cx30 and Cx43 was significantly decreased in mPFC and hippocampus of CSDS mice and was strongly associated with decreases in neuronal activity. Furthermore, overexpression of Cx30 and Cx43 in the mPFC and hippocampus increased neuronal activity and inhibited depressive-like behaviours; while suppression of Cx30 and Cx43 in normal mice was sufficient to reduce neuronal activity and induced depressive-like behaviours. Taken togetner, aberrant expression of astrocytic Cx30 and Cx43 in the mPFC and hippocampus significantly affects brian region-specific neuronal activity and drives depressive-like behaviours. These observations provide novel insights into the role of astrocyte gene expression in stress-induced depressive-like behaviours.


Assuntos
Conexina 30/metabolismo , Conexina 43/metabolismo , Depressão/metabolismo , Animais , Astrócitos/metabolismo , Encéfalo/metabolismo , Conexina 30/fisiologia , Conexinas/metabolismo , Depressão/fisiopatologia , Modelos Animais de Doenças , Hipocampo/metabolismo , Masculino , Camundongos , Camundongos Transgênicos , Neurônios/metabolismo , Córtex Pré-Frontal/metabolismo , Lobo Temporal/metabolismo
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...