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1.
Rev Sci Instrum ; 87(5): 055108, 2016 05.
Artigo em Inglês | MEDLINE | ID: mdl-27250471

RESUMO

Force tests were conducted at the long-duration-test shock tunnel JF12, which has been designed and built in the Institute of Mechanics, Chinese Academy of Sciences. The performance tests demonstrated that this facility is capable of reproducing a flow of dry air at Mach numbers from 5 to 9 at more than 100 ms test duration. Therefore, the traditional internal strain-gauge balance was considered for the force tests use in this large impulse facility. However, when the force tests are conducted in a shock tunnel, the inertial forces lead to low-frequency vibrations of the test model and its motion cannot be addressed through digital filtering because a sufficient number of cycles cannot be found during a shock tunnel run. The post-processing of the balance signal thus becomes extremely difficult when an averaging method is employed. Therefore, the force measurement encounters many problems in an impulse facility, particularly for large and heavy models. The objective of the present study is to develop pulse-type sting balance by using a strain-gauge sensor that can be applied in the force measurement of 100 ms test time, especially for the force test of the large-scale model. Different structures of the S-series (i.e., sting shaped balances) strain-gauge balance are proposed and designed, and the measuring elements are further optimized to overcome the difficulties encountered during the measurement of aerodynamic force in a shock tunnel. In addition, the force tests were conducted using two large-scale test models in JF12 and the S-series strain-gauge balances show good performance in the force measurements during the 100 ms test time.

2.
Nano Lett ; 16(6): 3754-9, 2016 06 08.
Artigo em Inglês | MEDLINE | ID: mdl-27183049

RESUMO

Precise assembly of semiconductor heterojunctions is the key to realize many optoelectronic devices. By exploiting the strong and tunable van der Waals (vdW) forces between graphene and organic small molecules, we demonstrate layer-by-layer epitaxy of ultrathin organic semiconductors and heterostructures with unprecedented precision with well-defined number of layers and self-limited characteristics. We further demonstrate organic p-n heterojunctions with molecularly flat interface, which exhibit excellent rectifying behavior and photovoltaic responses. The self-limited organic molecular beam epitaxy (SLOMBE) is generically applicable for many layered small-molecule semiconductors and may lead to advanced organic optoelectronic devices beyond bulk heterojunctions.

3.
J Photochem Photobiol B ; 127: 28-37, 2013 Oct 05.
Artigo em Inglês | MEDLINE | ID: mdl-23928159

RESUMO

Techniques to enhance tumor targeting and to improve the aqueous solubility of anticancer drugs and photosensitizers have recently been the focus of much research. In this study, a folate-PEG-conjugated chlorin was synthesized and characterized. Because of the use of PEG as a linker, the new chlorin displayed increased aqueous solubility, with a solubility of 40.1mg/mL in PBS, and showed lower aggregation and cytotoxicity than its precursor, chlorin. Meanwhile, the introduction of folic acid to the new chlorin resulted in increased selectivity for folate-receptor-positive tumor cells (HeLa and Hep-2 cells); the cellular uptake of the new chlorin by HeLa and Hep-2 cells was strikingly higher than that of the precursor chlorin, and the photocytotoxicities of the new chlorin to HeLa and Hep-2 cells were 2.5 and 3.5 times greater than that of folate-free conjugate chlorin. During photodynamic therapy mediated by the new chlorin, both type I and type II reactions occur simultaneously.


Assuntos
Ácido Fólico/química , Terapia de Alvo Molecular , Fotoquimioterapia , Polietilenoglicóis/química , Porfirinas/química , Porfirinas/farmacologia , Água/química , Antineoplásicos/química , Antineoplásicos/metabolismo , Antineoplásicos/farmacologia , Antineoplásicos/toxicidade , Transporte Biológico , Receptor 1 de Folato/metabolismo , Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos , Regulação Neoplásica da Expressão Gênica/efeitos da radiação , Células HeLa , Células Hep G2 , Humanos , Fármacos Fotossensibilizantes/química , Fármacos Fotossensibilizantes/metabolismo , Fármacos Fotossensibilizantes/farmacologia , Fármacos Fotossensibilizantes/toxicidade , Porfirinas/metabolismo , Porfirinas/toxicidade , Solubilidade
4.
J Pharm Anal ; 2(4): 293-297, 2012 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-29403756

RESUMO

The nanocomposites of poly-diallyldimethylammonium chloride (PDADMAC) and CdTe quantum dots (QDs) (i.e. QDs-PDADMAC nanocomposites) have been prepared based on electrostatic interaction and their fluorescence stability in aqueous solution has been investigated. MTT method (3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide method) was used to study their cytotoxicity and A549 lung cancer cell as a model cell was also used to evaluate their cellular imaging. It was shown that the fluorescence stability of QDs-PDADMAC nanocomposites was much better than that of bare QDs both in aqueous solution and cell. Meanwhile, QDs-PDADMAC nanocomposites display very low cytotoxicity in the low concentrations and better staining ability compared with QDs. QDs-PDADMAC nanocomposites will have great advantage on the cell analysis detection and imaging.

5.
Guang Pu Xue Yu Guang Pu Fen Xi ; 30(4): 865-8, 2010 Apr.
Artigo em Chinês | MEDLINE | ID: mdl-20545119

RESUMO

There are some impurities such as aluminum dioxide adhering on the shock tube wall due to the ablating and heating of the aluminum diaphragm by high temperature gas. Under high temperature, the collision of AlO radicals with the gaseous molecules leads to transition of the electronic states and production of strong radiation, which disturb the analysis of radiation spectrum of heated gases in shock tube. In the authors' experiments, the air in the test section with adhering aluminum dioxide was heated to some 4 000-7 000 K, the spectrum of AlO radical was obvious in the range of 460-530 nm, which corresponds to B 2sigma(+)-X 2sigma+ (T00 = 20 689 cm(-1) band. There were several band heads for this band, the interval of neighbor heads was some 2 nm, and all the band heads were with the shortest wavelength. The characteristics of B 2sigma(+)-X 2sigma+ band were explored in experiment and by theory. In addition, the spectrum of C 2pi(r)-X 2sigma+ (T00 = 33 047 cm(-1)) band was also investigated. The corresponding strength was lower than that of B 2sigma(+) -X 2sigma+ band, and the wavelength range of this band was some 270-335 nm where the radiation of A 2sigma(+) -X 2pi (T00 = 32 682 cm(-1)) band of OH radical also existed. This occurrence of the two bands in the same wavelength range is disadvantageous for the spectrum analysis.

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