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1.
Artigo em Inglês | MEDLINE | ID: mdl-31479744

RESUMO

The obligate intracellular parasite Toxoplasma gondii can infect nearly all warm-blooded animals including humans. Although infection with this parasite is generally benign, severe illness may occur in the infected individuals if their immunity becomes less competent, such as AIDS patients. In this study, we determined the inhibitory activity of 44 commonly used antiretroviral compounds against T. gondii in vitro. Fourteen of the 44 tested antiretroviral compounds showed potency against T. gondii at IC50 concentrations that ranged from 1.18 ± 2.21 µM (nelfinavir) to 18.89 ± 1.87 µM (trovirdine). Seven of the 14 potent antiretroviral compounds are HIV-1 protease inhibitors. We investigated whether co-administration of these 14 antiretroviral compounds interferes with the anti-T. gondii activity of the existing anti-T. gondii drugs, sulfadiazine or pyrimethamine. Results showed no significant interaction between any of the tested 14 antiretroviral compounds and pyrimethamine or sulfadiazine. These results warrant the investigation of whether the administration of the lead antiretroviral drugs with highly potent anti-T. gondii activity to AIDS patients may help in limiting the occurrence of toxoplasmic encephalitis.

2.
Artigo em Inglês | MEDLINE | ID: mdl-31385422

RESUMO

Lithium metal is used to achieve high-energy-density batteries due to its large theoretical capacity and low negative electrochemical potential. The introduction of quasi-solid electrolytes simultaneously overcomes the safety problems induced by the liquid electrolytes and the high interfacial resistance issues confronted by all solid-state electrolytes. In-depth investigations involving interfacial behaviors in quasi-solid lithium metal batteries are inadequate. Herein an ultrathin Li3 OCl quasi-solid-state electrolyte layer (500 nm thickness) is used to cover a lithium anode. The polarization of the anode is remarkably reduced by introducing the Li3 OCl quasi-solid-state electrolyte. In contrast to the decomposition of solvents in a standard electrolyte (EC-DEC,1.0 m LiPF6 ), the established quasi-solid-state electrolyte interfaces can significantly inhibit the decomposition of solvents when the cut-off voltage is 4.5 V.

3.
Artigo em Inglês | MEDLINE | ID: mdl-31428887

RESUMO

PURPOSE: To identify the disease-causing gene in a family with female infertility and fertilization failure. METHODS: Whole-exome sequencing and Sanger sequencing were used to identify the disease-causing gene in a female with infertility and fertilization failure. Subcellular localization and western blot analysis were used to check the effect of mutations. RESULTS: We identified novel compound heterozygous mutations c.598C>T (p.Arg200Ter) and c.1319G>C (p.Trp440Ser) in WEE2 gene in a female with infertility and fertilization failure. The p.Arg200Ter mutant WEE2 gene produce truncated protein and mainly located in the nucleus, the same as the wild protein, while the p.Trp440Ser mutant WEE2 proteins are located in the nucleus and cytoplasm and the expression level of p.Trp440Ser mutant WEE2 protein is reduced significantly compared with that of wild-type WEE2. CONCLUSIONS: We discovered novel compound heterozygous mutations c.598C>T (p.Arg200Ter) and c.1319G>C (p.Trp440Ser) in WEE2 gene in a female whose oocytes could not form pronucleus after intracytoplasmic sperm injection (ICSI). Moreover, mutations in WEE2 gene affect the normal function of WEE2 proteins and cause fertilization failure.

4.
Nanoscale ; 11(32): 15147-15155, 2019 Aug 15.
Artigo em Inglês | MEDLINE | ID: mdl-31373342

RESUMO

Janus nanoparticles (NPs) containing two chemically distinct materials in one system are of great significance for catalysis in terms of harnessing catalytic synergies that do not exist in either component. We herein present a novel synthetic method of two Janus-type MnOx-Ag and MnOx-AgI NPs. The synthesis of Janus-type MnOx-AgI NPs is based on the oxidative nucleation and growth of Ag domains on MnO first and the subsequent iodization of Ag. A mild and non-disruptive iodization strategy is developed to yield Janus MnOx-AgI NPs, in which converting Ag to AgI domains with iodomethane (CH3I) is achieved through partial iodization. Simultaneously, Mn2+ species in the primary MnO octahedra are oxidized during the growth of Ag NPs, leading to the formation of amorphous p-type MnOx domains. Therefore, the as-resultant Janus-type MnOx-AgI NPs combining two semiconductors into an integrated nanostructure can be used as an efficient photocatalyst for visible-light-driven water oxidation. Janus MnOx-AgI NPs show an expected photocatalytic activity even in the absence of Ru(bpy)3Cl2 as an electron mediator. This intriguing synthesis may offer a new opportunity to develop asymmetric nanostructures of two semiconductors that will potentially be efficient photocatalysts for solar-driven water splitting.

5.
J Chem Neuroanat ; : 101661, 2019 Aug 10.
Artigo em Inglês | MEDLINE | ID: mdl-31408693

RESUMO

Monosynaptic tracing using deletion-mutant rabies virus allows whole-brain mapping of neurons that are directly presynaptic to a targeted population of neurons. The most common and robust way of implementing it is to use Cre mouse lines in combination with Cre-dependent adeno-associated viral vectors for expression of the required genes in the targeted neurons before subsequent injection of the rabies virus. Here we present a step-by-step protocol for performing such experiments using first-generation (ΔG) rabies viral vectors.

6.
Cell Rep ; 28(5): 1323-1334.e4, 2019 Jul 30.
Artigo em Inglês | MEDLINE | ID: mdl-31365873

RESUMO

Retinitis pigmentosa (RP) initiates with diminished rod photoreceptor function, causing peripheral and night-time vision loss. However, subsequent loss of cone function and high-resolution daylight and color vision is most debilitating. Visual pigment-rich photoreceptor outer segments (OS) undergo phagocytosis by the retinal pigment epithelium (RPE), and the RPE also acts as a blood-outer retinal barrier transporting nutrients, including glucose, to photoreceptors. We provide evidence that contact between externalized phosphatidylserine (PS) on OS tips and apical RPE receptors activates Akt, linking phagocytosis with glucose transport to photoreceptors for new OS synthesis. As abundant mutant rod OS tips shorten in RP, Akt activation is lost, and onset of glucose metabolism in the RPE and diminished glucose transport combine to cause photoreceptor starvation and accompanying retinal metabolome changes. Subretinal injection of OS tip mimetics displaying PS restores Akt activation, glucose transport, and cone function in end-stage RP after rods are lost.

7.
Artigo em Inglês | MEDLINE | ID: mdl-31420867

RESUMO

OBJECTIVE: To examine whether gestational hypertension and pre-eclampsia are associated with spontaneous premature rupture of membranes (PROM). METHODS: A retrospective, population-based cohort study was conducted in Hebei, Zhejiang, and Jiangsu provinces in China from 1993 to 1995. After excluding women with missing data of exposure and outcome, history of chronic hypertension, multiple births, and babies with major birth defects and ambiguous sex, this study comprised 199 231 singleton live births. Logistic regression was used to evaluate the association, adjusting for potential confounders. RESULTS: The incidence of PROM was 17.7% and 8.9% in women with gestational hypertension and pre-eclampsia, respectively, and 5.9% for the normotensive group. Compared with normotension, gestational hypertension was associated with an increase in the odds of PROM of 4.21 times (95% confidence interval [CI] 3.77-4.70), while pre-eclampsia had an increase of 2.27 times (95% CI 1.78-2.88). Additionally, women with hypertensive disorders of pregnancy had higher risks for term PROM (adjusted risk ratio [RR] 3.83, 95% CI 3.43-4.27) than preterm PROM (adjusted RR 3.10, 95% CI 2.18-4.41). Consistent results of the association were also observed in the sensitivity analyses. CONCLUSION: Gestational hypertension and pre-eclampsia were associated with an increased risk for PROM. Increased odds were observed for term PROM compared with preterm PROM.

8.
Artigo em Inglês | MEDLINE | ID: mdl-31469269

RESUMO

Single-ion conducting polymer electrolyte (SICPE) is a safer alternative to the conventional high-performance liquid electrolyte for Li-ion batteries. The performance of SICPEs based Li-ion batteries is limited due to the low Li+ conductivities of SICPEs at room temperature. Herein, we demonstrated the synthesis of a novel SICPE, poly (ethylene-co-acrylic lithium (fluoro sulfonyl)imide) (PEALiFSI) with acrylic (fluoro sulfonyl)imide) anion (AFSI). The solvent and plasticizer-free PEALiFSI electrolyte, which was assembled at 90 °C under pressure, exhibited self-healing properties with remarkably high Li+ conductivity (5.84×10-4 S/cm at 25 °C). This is mainly due to the self-healing behavior of this electrolyte, which induced to increase the proportion of the amorphous phase. Additionally, the weak interaction of Li+ with the resonance stabilized AFSI anion is also responsible for high Li+conductivity. This self-healed SICPE showed high Li+ transference number (ca. 0.91), flame and heat retardancy, and good thermal stability, which concurrently delivered ca. 88.25% (150 mAh/g at 0.1 C) of the theoretical capacitance of LiFePO4 cathode material at 25 °C with the full cell configuration of LiFePO4/PEALiFSI/graphite. Furthermore, the self-healed PEALiFSI based all-solid-state Li-battery showed high electrochemical cycling stability with the capacity retention of 95% after 500 charge-discharge cycles.

9.
RNA ; 2019 Aug 07.
Artigo em Inglês | MEDLINE | ID: mdl-31391217

RESUMO

RNA kissing complexes are essential for genomic RNA dimerization and regulation of gene expression, and their structures and stability are critical to their biological functions. In this work, we employed our previously developed coarse-grained model with an implicit structure-based electrostatic potential to predict 3D structures and stability of RNA kissing complexes in salt solutions. For extensive RNA kissing complexes, our model shows great reliability in predicting 3D structures from their sequences, and our additional predictions indicate that the model can capture the dependence of 3D structures of RNA kissing complexes on monovalent/divalent ion concentrations. Moreover, the comparisons with extensive experimental data show that the model can make reliable predictions on the stability for various RNA kissing complexes over wide ranges of monovalent/divalent ion concentrations. Notably, for RNA kissing complexes, our further analyses show the important contribution of coaxial stacking to the 3D structures and stronger stability than the corresponding kissing-interface duplexes at high salts. Furthermore, our comprehensive analyses for RNA kissing complexes reveal that the thermally folding pathway for a complex sequence is mainly determined by the relative stability of two possible folded states of kissing complex and extended duplex, which can be significantly modulated by its sequence.

10.
Sensors (Basel) ; 19(16)2019 Aug 07.
Artigo em Inglês | MEDLINE | ID: mdl-31394850

RESUMO

This paper presents the design and analysis of a new micro-electro-mechanical system (MEMS) tuning fork gyroscope (TFG), which can effectively improve the mechanical sensitivity of the gyroscope sense-mode by the designed leverage mechanism. A micromachined TFG with an anchored leverage mechanism is designed. The dynamics and mechanical sensitivity of the design are theoretically analyzed. The improvement rate of mechanical sensitivity (IRMS) is introduced to represent the optimization effect of the new structure compared with the conventional one. The analytical solutions illustrate that the IRMS monotonically increases with increased stiffness ratio of the power arm (SRPA) but decreases with increased stiffness ratio of the resistance arm (SRRA). Therefore, three types of gyro structures with different stiffness ratios are designed. The mechanical sensitivities increased by 79.10%, 81.33% and 68.06% by theoretical calculation. Additionally, FEM simulation demonstrates that the mechanical sensitivity of the design is in accord with theoretical results. The linearity of design is analyzed, too. Consequently, the proposed new anchored leverage mechanism TFG offers a higher displacement output of sense mode to improve the mechanical sensitivity.

11.
Birth Defects Res ; 2019 Jul 22.
Artigo em Inglês | MEDLINE | ID: mdl-31332962

RESUMO

BACKGROUND: Neural tube defects (NTDs) are the most common severe birth defects with complex etiologies. Previous studies conducted on animals have suggested that the Grhl3 gene is essential for closure of the spinal neural tube, but little evidence from human studies on the variants of GRHL3 gene has been provided, especially the common genetic variants. METHODS: To investigate the relationship between common genetic variants of GRHL3 and the risk for NTDs, we performed a case-control study and a case-parent triad/control study. Fast-target enrichment sequencing was performed to screen exon regions from 503 NTD cases, and three tag SNPs (single nucleotide polymorphisms, including rs12030057, rs2486668, and rs545809) were selected according to the sequencing results. Then, Sequenom MassARRAY genotyping was performed in 757 case parents and 519 controls to obtain genotype information of the target variant sites among all NTD triads and controls. RESULTS: The genotype distributions of all SNPs were in accordance with Hardy-Weinberg Equilibrium (HWE) in the control population. In the case-control study, significant associations were found between C27G genetic variants on rs2486668 and risk for spina bifida and encephalocele, respectively, under different genetic models. Consistently, in the case-parent triad/control study, GG genotype on rs2486668 was associated with increased risk for spina bifida, with a RR of 2.15 (95% CI: 1.20-3.83). However, no parent-of-origin effect was found for any tag SNPs. CONCLUSION: The GRHL3 C67G missense variant may increase the risk for spina bifida and encephalocele phenotypes.

12.
Front Immunol ; 10: 1531, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31333663

RESUMO

We characterized the porcine tissue transcriptional landscapes that follow Toxoplasma gondii infection. RNAs were isolated from liver, spleen, cerebral cortex, lung, and mesenteric lymph nodes (MLNs) of T. gondii-infected and uninfected (control) pigs at days 6 and 18 postinfection, and were analyzed using next-generation sequencing (RNA-seq). T. gondii altered the expression of 178, 476, 199, 201, and 362 transcripts at 6 dpi and 217, 223, 347, 119, and 161 at 18 dpi in the infected brain, liver, lung, MLNs and spleen, respectively. The differentially expressed transcripts (DETs) were grouped into five expression patterns and 10 sub-clusters. Gene Ontology enrichment and pathway analysis revealed that immune-related genes dominated the overall transcriptomic signature and that metabolic processes, such as steroid biosynthesis, and metabolism of lipid and carboxylic acid, were downregulated in infected tissues. Co-expression network analysis identified transcriptional modules associated with host immune response to infection. These findings not only show how T. gondii infection alters porcine transcriptome in a tissue-specific manner, but also offer a gateway for testing new hypotheses regarding human response to T. gondii infection.

13.
Soc Sci Med ; 235: 112345, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31276967

RESUMO

During recent decades, China has experienced rapid economic growth, but the authoritarian state has continued to hold tight control over the access to political power. Scholars have long suspected that the incongruence between growing economic resources and lack of political power may spawn dissatisfaction and anxiety. But little empirical research has systematically assessed the incongruence and its psychological consequences in China. Moreover, social theorists have disagreed on the consequences of status incongruence and empirical examination has been inconclusive so far. Therefore, we ask: 1) do Chinese people perceive the incongruence between their economic conditions and access to power? And 2) does this incongruence affect their psychological well-being? We applied the diagonal mobility model from stratification research to analyze data from a nationally representative survey in China so as to assess the incongruence between power and wealth status and adjudicate its consequences. We found that Chinese people perceived substantial gaps in their power and wealth status. Contrary to what theorists of status inconsistency expect, the incongruence between power and wealth status does not harm psychological well-being. Consistent with the prediction of the synthesizing approach, individuals tend to emphasize the status dimension in which they enjoy advantages and discount the dimension in which they suffer detriments. Adding to the literature on the social determinants of health, this study shows how the multi-dimensional nature of social stratification affect the disparities of psychological well-being in contemporary China.

14.
Food Chem ; 301: 125226, 2019 Dec 15.
Artigo em Inglês | MEDLINE | ID: mdl-31357003

RESUMO

The glutenin (Glu) and gliadin (Gli) were modified by protein-glutaminase (PG) to obtain soluble glutenin (PG-Glu) and gliadin (PG-Gli), and PG-Glu or PG-Gli was added to potato starch (PS) according to different amounts (0.5%, 1.0%, and 1.5%, based on dry starch weight, w/w) to explore the effect of modified proteins on the retrogradation behavior and digestibility of PS. The results showed that the long-term retrogradation of PS was accelerated by the addition of PG-Glu or PG-Gli. The addition of PG-Glu or PG-Gli led to an increase in hydrogen bonds within starch molecules and induced a significant increase in resistant starch content. The hydrolysis kinetic parameters, C∞ and K, both decreased with the increasing level of modified protein, indicating the deceleration of hydrolysis rate by the addition of PG-Glu or PG-Gli. In summary, the addition of PG-Glu or PG-Gli could promote the retrogradation of PS and mitigate the digestion of starch.

15.
Biomolecules ; 9(8)2019 Jul 24.
Artigo em Inglês | MEDLINE | ID: mdl-31344975

RESUMO

Electronegative low-density lipoprotein (LDL(-)) is a minor LDL subfraction that is present in blood with inflammatory and apoptotic effects. We aimed to evaluate the role of sphingolipids ceramide (Cer), sphingosine (Sph), and sphingosine-1-phosphate (S1P) in the LDL(-)-induced effect on monocytes. Total LDL was subfractioned into native LDL and LDL(-) by anion-exchange chromatography and their sphingolipid content evaluated by mass spectrometry. LDL subfractions were incubated with monocytes in the presence or absence of enzyme inhibitors: chlorpromazine (CPZ), d-erythro-2-(N-myristoyl amino)-1-phenyl-1-propanol (MAPP), and N,N-dimethylsphingosine (DMS), which inhibit Cer, Sph, and S1P generation, respectively. After incubation, we evaluated cytokine release by enzyme-linked immunosorbent assay (ELISA) and apoptosis by flow cytometry. LDL(-) had an increased content in Cer and Sph compared to LDL(+). LDL(-)-induced cytokine release from cultured monocytes was inhibited by CPZ and MAPP, whereas DMS had no effect. LDL(-) promoted monocyte apoptosis, which was inhibited by CPZ, but increased with the addition of DMS. LDL enriched with Sph increased cytokine release in monocytes, and when enriched with Cer, reproduced both the apoptotic and inflammatory effects of LDL(-). These observations indicate that Cer content contributes to the inflammatory and apoptotic effects of LDL(-) on monocytes, whereas Sph plays a more important role in LDL(-)-induced inflammation, and S1P counteracts apoptosis.

16.
Cancer Immunol Immunother ; 68(8): 1369-1378, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31338558

RESUMO

Intrahepatic cholangiocarcinoma (ICC) is a rare malignancy with poor prognosis. The evaluation of recurrence risk after liver resection is of great importance for ICCs. We aimed to assess the prognostic value of intra- and peritumoral immune infiltrations and to establish a novel histopathology-related immunoscore (HRI) associated with ICC recurrence. A total of 280 ICC patients who received curative resection between February 2005 and July 2011 were enrolled in our study. Patients were randomly assigned to the derivation cohort (n = 176) or the validation cohort (n = 104). Sixteen immune biomarkers in both intra- and peritumoral tissues were examined by immunohistochemistry. The least absolute shrinkage and selection operator (LASSO) Cox model was used to establish the HRI score. Cox regression analysis was used for multivariate analysis. Nine recurrence-related immune features were identified and integrated into the HRI score. The HRI score was used to categorize patients into low-risk and high-risk groups using the X-tile software. Kaplan-Meier analysis presented that the HRI score showed good stratification between low-risk and high-risk groups in both the derivation cohort (P < 0.001) and the validation cohort (P = 0.014), respectively. Multivariate analysis demonstrated that serum γ-glutamyl transpeptidase, carbohydrate antigen 19-9, lymphoid metastasis, tumor numbers, and the HRI score were independent risk factors associated with recurrence-free survival (RFS). The combination of Shen's model and HRI score provided better performance in recurrence prediction compared with traditional staging systems. The HRI score might serve as a promising RFS predictor for ICC with prognostic values.


Assuntos
Antígenos Glicosídicos Associados a Tumores/metabolismo , Biomarcadores Tumorais/metabolismo , Colangiocarcinoma/diagnóstico , Neoplasias Hepáticas/diagnóstico , Fígado/metabolismo , Colangiocarcinoma/mortalidade , Colangiocarcinoma/patologia , Estudos de Coortes , Feminino , Hepatectomia , Humanos , Fígado/patologia , Neoplasias Hepáticas/mortalidade , Neoplasias Hepáticas/patologia , Masculino , Pessoa de Meia-Idade , Metástase Neoplásica , Recidiva Local de Neoplasia , Prognóstico , Projetos de Pesquisa , Análise de Sobrevida , Carga Tumoral , gama-Glutamiltransferase/metabolismo
17.
Life Sci ; 232: 116619, 2019 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-31265855

RESUMO

AIMS: Clinical treatment strategies for patients with myocardial ischemia typically include coronary artery recanalization to restore myocardial blood supply. However, myocardial reperfusion insult often induces oxidative stress and inflammation, which further leads to apoptosis and necrosis of myocardial cells. Increasing evidence suggests that microRNAs (miRNAs) participate in the pathological and physiological processes associated with myocardial ischemia reperfusion. MAIN METHODS: In this study, we established a myocardial H/R H9C2 cell model and a mouse I/R model to detect molecules implicated in myocardial I/R regulation and to determine the underlying signal transduction pathways. KEY FINDINGS: Herein, we showed that the expression of miR-374a-5p decreased in a myocardial cell model (H9C2 cells) of hypoxia/reoxygenation (H/R) and mouse model of ischemia/reperfusion (I/R). Alternatively, overexpression of miR-374a-5p was found to ameliorate myocardial cell damage within both in vivo and in vitro models of ischemia. Further, mitogen-activated protein kinase 6 (MAPK6) was identified as a direct target of miR-374a-5p. Thus, by targeting MAPK6, miR-374a-5p was found to negatively regulate MAPK6 expression. However, up-regulation of MAPK6 functioned to inhibit the previously observed protective effect of miR-374a-5p in the H9C2 H/R model. SIGNIFICANCE: Taken together, our study suggests that miR-374a-5p may have protective effects against cardiac I/R injury in vivo, and H/R injury in vitro, thereby providing novel insights into the molecular mechanisms associated with ischemia/reperfusion injury and a potential novel therapeutic target.

18.
Nano Lett ; 2019 Aug 08.
Artigo em Inglês | MEDLINE | ID: mdl-31361961

RESUMO

The construction of multiple types of active sites on the surface of a metallic catalyst can markedly enhance its catalytic activity toward specific reactions. Here, we show that heterophase gold nanowires (Au NWs) with multiple types of active surface sites can be synthesized using an etching-assisted process, yielding the highest reported turnover frequency (TOF) for Au catalysts toward the silane oxidation reaction by far. We use synchrotron powder X-ray diffraction (PXRD) and aberration-corrected (scanning) transmission electron microscopy (TEM) to show that the Au NWs contain heterophase structures, planar defects, and surface steps. Moreover, the contribution to the catalytic performance from each type of active sites was clarified. Surface steps on the Au NW catalysts, which were identified using aberration-corrected (scanning) TEM, were shown to play the most important role in enhancing the catalytic performance. By using synchrotron PXRD, it was shown that a small ratio of metastable phases within Au NWs can enhance catalytic activity by a factor of 1.35, providing a further route to improve catalytic activity. Of the three types of surface active sites, surface terminations of planar defects such as twin boundaries (TB) and stacking faults (SF) are less active than metastable phases and surface steps for Au catalysts toward the silane oxidation reaction. Such an etching-assisted synthesis of heterophase Au NWs promises to open new possibilities for catalysis, plasmonic, optics, and electrical applications.

19.
J Matern Fetal Neonatal Med ; : 1-9, 2019 Aug 04.
Artigo em Inglês | MEDLINE | ID: mdl-31331218

RESUMO

Background: Hypoxic-ischemic encephalopathy (HIE) is one of the most serious birth complications for neonates. Few studies reported the relationship between maternal blood pressure disorders and risk of neonatal HIE. Objective: This study was conducted to examine whether maternal hypertensive disorders in pregnancy increase the risk of HIE. Methods: The analyses were performed using data from a large population-based cohort study aiming to prevent neural tube defects by supplementation with folic acid. The subjects comprised 183,981 women with singleton live births delivered at gestational ages of 32-42 weeks, who registered in two southern provinces in China. Blood pressure was measured by trained health care workers at each prenatal visit. Diagnosis information on HIE was recorded at the time of delivery. Results: Totally 19,298 women (10.49%) were diagnosed with maternal hypertensive disorders in pregnancy and 255 infants (1.4 per 1000) with HIE, respectively. Compared with the normotensive group, a great increment in the risk of HIE was observed in women with hypertensive disorders (adjusted RR = 2.40, 95% confidence interval [CI]: 1.79-3.22) after adjusting for maternal confounding factors. A greater association was presented among preterm (32-36 weeks) infants with an adjusted RR of 5.45 (95% CI: 2.79, 10.65) compared to a RR of 2.09 (95% CI: 1.49, 2.92) among full-term (37-42 weeks) infants (p for heterogeneity < .05). Further stratification analyses showed that no matter with or without small for gestational age (SGA), maternal hypertensive disorders were associated with the increased risk for HIE. Sensitivity analyses excluding infants with low or high birth weight did not appreciably change the findings. Conclusions: Our present study demonstrated a positive association of maternal hypertensive disorders in pregnancy with the risk of neonatal HIE.

20.
Curr Med Sci ; 39(4): 631-637, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31347001

RESUMO

The aim of this study was to determine the association between thyroid-stimulating hormone (TSH) level and pregnancy outcomes in euthyroid women undergoing in vitro fertilization (IVF)/intra-cytoplasmic sperm injection (ICSI). A total of 1185 women were enrolled in the retrospective study, and 12 studies with a total of 6624 women were included in the meta-analysis (including the data of the present retrospective study). Participants in the retrospective study were divided into two groups in terms of their serum TSH levels: TSH ≤2.5 mIU/L group (n=830) and TSH >2.5 mIU/L group (n=355). They were monitored for the status of clinical pregnancy or miscarriage. In the TSH ≤2.5 mIU/L group, 441 (53.1%) women achieved clinical pregnancy, while 48 (5.8%) had early pregnancy loss and 12 (1.4%) had ectopic pregnancy. In the TSH >2.5 mIU/L group, 175 (49.3%) women achieved clinical pregnancy, while 21 (5.9%) had early pregnancy loss and 3 (0.8%) had ectopic pregnancy. No significant differences were observed between the two groups in pregnancy outcomes (P=0.126, P=0.512, P=0.297). The meta-analysis also revealed no significant difference in the clinical pregnancy rate and the miscarriage rate between women with serum TSH ≤2.5 mIU/L and those with serum TSH >2.5 mIU/L. In conclusion, high TSH levels (TSH level >2.5 mIU/L) did not affect clinical pregnancy rate or increase miscarriage rate in euthyroid women undergoing IVF/ICSI.

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