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1.
Orv Hetil ; 160(48): 1894-1903, 2019 Dec.
Artigo em Húngaro | MEDLINE | ID: mdl-31760773

RESUMO

Introduction: According to the Hungarian law, placental examination is not mandatory, although it is known from the international practice that it can give valuable information in cases of stillbirth or in conditions, where the neonate has difficulty in the postnatal adaptation. Aim: It can be useful in the early detection of diseases, which otherwise would have gone undetected until late in life. This article is unique in Hungary, as no similar guideline exists in Hungarian language. Method: The recommendation of the Royal College of Pathologists (United Kingdom) determines those conditions where essential information can be obtained from the placental examination in not normal pregnancies. It serves as a useful guide in the medical practice. The journal titled "Placenta", first published in 1980 with impact factor above two, just underlines this statement. Results: In this article, the authors present the recent guideline of the RCPath and finish with the presentation of established clinicopathological association that might help clinicians to get the most valuable information from placental examination. Conclusion: The present article aims to summarise updated recommendations and present clinicopathological correlations. Orv Hetil. 2019; 160(48): 1894-1903.


Assuntos
Placenta/patologia , Guias de Prática Clínica como Assunto , Natimorto , Feminino , Humanos , Hungria , Recém-Nascido , Gravidez , Sociedades Médicas , Cordão Umbilical/patologia , Reino Unido
2.
Acta Microbiol Immunol Hung ; 65(4): 459-465, 2018 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-29552897

RESUMO

Enterobiasis is an easily recognizable and treatable disease with higher incidence among children. Based on these facts, its clinical importance is usually underestimated. This infection also occurs during adulthood and without treatment, it can cause severe complications in some rare cases. Unnoticed subclinical infection in women can lead to infertility and even to life-threatening conditions. It is also emphasized in this paper that the treatment of identified enterobiasis during pregnancy needs caution. After reviewing the current scientific literature, two gynecological cases are presented here.


Assuntos
Enterobíase/complicações , Enterobíase/epidemiologia , Enterobius/isolamento & purificação , Infertilidade Feminina/epidemiologia , Complicações Infecciosas na Gravidez/tratamento farmacológico , Complicações Infecciosas na Gravidez/epidemiologia , Animais , Anti-Helmínticos/uso terapêutico , Enterobíase/tratamento farmacológico , Tubas Uterinas/parasitologia , Tubas Uterinas/patologia , Feminino , Histocitoquímica , Humanos , Incidência , Infertilidade Feminina/etiologia , Mebendazol/uso terapêutico , Microscopia , Gravidez
3.
Pregnancy Hypertens ; 8: 51-59, 2017 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-28501280

RESUMO

OBJECTIVES: The purpose of this study was to assess three-dimensional placental power Doppler indices in second and third trimester of pregnancies complicated by chronic-, gestational hypertension or pre-eclampsia. METHODS: We analyzed 226 pregnancies prospectively measuring three-dimensional placental power Doppler indices (vascularization index, flow index, vascularization flow index) in cases of normal blood pressure (N=109), chronic hypertension (N=43), gestational hypertension (N=57) and pre-eclampsia (N=17). We evaluated the correlation among vascularization indices, flow characteristics of uterine arteries and perinatal outcome. We assessed the influence of maternal factors (pregestational body mass index, previous pregnancies/deliveries, maternal age) on vascularization indices, and analyzed histological findings of placenta from pregnancy hypertension groups. RESULTS: Vascularization index was significantly higher (p=0.010) in pregnancies with chronic- and lower (p=0.152) in pregnancies with gestational hypertension and preeclampsia compared to the normal group. Flow index was significantly lower in all three pathological groups compared to normal group. Placental volume was significantly smaller (p<0.001) in all three pathological groups than in normal pregnancies at the time of delivery, and there was no significant difference between the three affected groups. The rate of adverse pregnancy outcomes showed no significant difference between the normal and chronic hypertension groups. We observed significantly lower 1', 5' and 10' APGAR scores (p<0.,001), and birth weight in preeclampsia compared to chronic-, gestational hypertension, and normal groups. Maternal factors had no influence on the development of the power Doppler indices. CONCLUSION: Vascularization indices seem good markers for the prediction of risks and adverse outcomes in case of pregnancy hypertension.


Assuntos
Hipertensão Induzida pela Gravidez/diagnóstico por imagem , Interpretação de Imagem Assistida por Computador , Imagem Tridimensional , Neovascularização Fisiológica , Placenta/irrigação sanguínea , Placentação , Pré-Eclâmpsia/diagnóstico por imagem , Ultrassonografia Doppler , Ultrassonografia Pré-Natal/métodos , Índice de Apgar , Peso ao Nascer , Estudos de Casos e Controles , Feminino , Humanos , Hipertensão Induzida pela Gravidez/fisiopatologia , Recém-Nascido de Baixo Peso , Recém-Nascido , Nascimento Vivo , Masculino , Pré-Eclâmpsia/fisiopatologia , Valor Preditivo dos Testes , Gravidez , Segundo Trimestre da Gravidez , Terceiro Trimestre da Gravidez , Estudos Prospectivos
5.
Orv Hetil ; 157(2): 70-3, 2016 Jan 10.
Artigo em Húngaro | MEDLINE | ID: mdl-26726142

RESUMO

INTRODUCTION: Although the natural history of cervical and oral human papillomavirus infection has been intensively investigated in the past years, the ability of this virus to infect oral and genital mucosae in the same individual and its potential to co-infect both cervical and oral mucosa are still unclear. AIM: The aim of the authors was to assess the presence of oropharyngeal human papillomavirus infection in women with cervical lesions in the South-Eastern Hungarian population. METHOD: The total of 103 women have been included in the study between March 1, 2013 and January 1, 2015. Brushing was used to collect cells from the oropharyngeal mucosa. Human papillomavirus DNA was detected using polymerase chain reaction, and Amplicor line blot test was used for genotyping. RESULTS: Oropharyngeal human papillomavirus infection was detected in 2 cases (3%). The detected genotypes were 31, 40/61 and 73 in the oropharyngeal region. CONCLUSIONS: The results indicate that in women with cervical lesions oropharyngeal human papillomavirus infection rarely occurs.


Assuntos
Orofaringe/virologia , Papillomaviridae/isolamento & purificação , Infecções por Papillomavirus/diagnóstico , Infecções por Papillomavirus/epidemiologia , Neoplasias do Colo do Útero/prevenção & controle , Cervicite Uterina/virologia , Vaginite/virologia , Adulto , DNA Viral/isolamento & purificação , Feminino , Genótipo , Humanos , Hungria/epidemiologia , Papillomaviridae/genética , Reação em Cadeia da Polimerase , Prevalência , Fatores de Risco , Neoplasias do Colo do Útero/virologia , Cervicite Uterina/epidemiologia , Esfregaço Vaginal , Vaginite/epidemiologia
6.
Orv Hetil ; 155(50): 1989-95, 2014 Dec 14.
Artigo em Húngaro | MEDLINE | ID: mdl-25481501

RESUMO

INTRODUCTION: The prevalence of intrauterine growth restriction is 4-5000/100,000 births, and they give the majority of perinatal morbidity. AIM: The aim of the authors was to compare the pathomorphologic data and vasoreactivity of umbilical vessels and placenta of small for date newborns to that of the normal pregnancies. METHOD: Samples of the umbilical cord and placenta were divided into case and control groups. Two 10 cm long segments were cut of the umbilical cord at placental insertion. Tissue bath experiment was performed on umbilical vessels and pathomorphologic data were collected according to the Royal College of Pathologists' protocol. RESULTS: After the development of basal tone, oxytocin and desmopressin did not enhance the vascular contraction, but the pathomorphological and ultrasonographic data were significantly different in the two groups. CONCLUSIONS: The results indicate that umbilical vessels might not have oxytocin or vasopressin receptors. The pathomorphologic and flowmetric differences could be the causes of small birth weight.


Assuntos
Peso ao Nascer , Retardo do Crescimento Fetal/patologia , Retardo do Crescimento Fetal/fisiopatologia , Placenta/irrigação sanguínea , Cordão Umbilical/irrigação sanguínea , Cordão Umbilical/fisiopatologia , Feminino , Retardo do Crescimento Fetal/diagnóstico por imagem , Idade Gestacional , Humanos , Recém-Nascido , Masculino , Placenta/diagnóstico por imagem , Placenta/patologia , Placenta/fisiopatologia , Gravidez , Ultrassonografia Pré-Natal , Artérias Umbilicais/patologia , Artérias Umbilicais/fisiopatologia , Veias Umbilicais/patologia , Veias Umbilicais/fisiopatologia
7.
Fetal Pediatr Pathol ; 31(1): 55-9, 2013 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-22764758

RESUMO

Sonographic scan revealed a homogenously hyperechogenic lesion in the right fetal lung with microcystic pattern by a primigravid women at 22nd weeks of gestation. A large congenital pulmonary airway malformation (CPAM) was suspected with a lesion-to-lung ratio over 90%. The microcystic image of this thoracic anomaly was moderately visible on magnetic resonance imaging (MRI) at that early stage of the pregnancy. Fetopsy confirmed the diagnosis as a pure microcystic CPAM following termination of pregnancy. A controlled prospective study could be performed to compare ultrasound as a diagnostic modality to the MRI, focusing on volumetry, signal characteristics, and follow-up/regression of fetal pulmonary malformations.


Assuntos
Malformação Adenomatoide Cística Congênita do Pulmão/diagnóstico , Imagem por Ressonância Magnética/métodos , Ultrassonografia Pré-Natal/métodos , Feminino , Humanos , Gravidez , Diagnóstico Pré-Natal/métodos
8.
Case Rep Med ; 2010: 354170, 2010.
Artigo em Inglês | MEDLINE | ID: mdl-21274281

RESUMO

Since the 1970s, about 30 cases of partial or complete trisomy 17p have been presented in the literature. Partial trisomies of the short arm of chromosome 17 are somewhat more common, but complete trisomy is quite rare. Most of these cases were described in infants and newborns; and to our knowledge only 3 cases of trisomy 17p have been detected intrauterine. Phenotypic features of trisomy 17p in fetuses are intrauterine growth retardation, ventriculomegaly, cleft lip and cleft palate, micrognathia, horseshoe kidneys, single umbilical artery, and congenital heart defects. The sonographic and foetopathologic findings of a pregnancy trisomy 17p11.2-pter with the deletion of the terminal portion of the chromosome 6 due to paternal balanced translocation are described in this case report.

9.
Pathol Oncol Res ; 15(1): 147-52, 2009 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-18575830

RESUMO

Edwards syndrome (trisomy of chromosome 18) is generally characterized by the disorders of central nervous system, as well as the musculoskeletal and genitourinary systems. In majority of the cases with trisomy 18 the following malformations can be found: ventricular septal defect, horseshoe kidneys, oesophageal atresia, omphalocele, facial clefts, diaphragmatic hernias and genital hypoplasia. We report a male patient with Edwards syndrome. The boy had a partial agenesis of corpus callosum, oesophageal atresia with tracheo-oesophageal fistula, renal agenesis, ventricular septal defect, Dandy-Walker cyst and low-set malformed ears. The first three features are unique based on previous literature reports on trisomy 18. This report allows a further delineation of the trisomy 18 syndrome.


Assuntos
Anormalidades Múltiplas/diagnóstico , Aberrações Cromossômicas , Cromossomos Humanos Par 18/genética , Trissomia , Anormalidades Múltiplas/genética , Adulto , Evolução Fatal , Feminino , Humanos , Lactente , Masculino , Síndrome
10.
Orv Hetil ; 148(27): 1281-5, 2007 Jul 08.
Artigo em Húngaro | MEDLINE | ID: mdl-17604265

RESUMO

The authors present a rare cause of pulmonary hypertension, which occurred in a 57-year-old woman. Postmortem examination discovered an adenocarcinoma with bronchioloalveolar growth pattern as a cause of severe dyspnoea, extreme pulmonary hypertension, and chronic cor pulmonale. The tumour involved all lobes of the lung. In the hilar lymph node metastasis was detectable. Histology showed tumour cell emboli in branches of the pulmonary arteries, intimal fibrosis, which was associated with fibrin precipitation and involvement of lymphatic vessels showing lymphangiosis carcinomatosa. The intrapulmonary dissemination of the adenocarcinoma could be caused by the isolated haematogenous dissemination via the thoracic duct. The authors discuss the possible pathomechanism of pulmonary hypertension and the way of tumour cell dissemination in the lung. They highlight the histological changes, which accompany the syndrome of pulmonary tumour thrombotic microangiopathy. In this case, which can be regarded rarely published in the literature, they emphasise the differential diagnostic questions.


Assuntos
Adenocarcinoma/complicações , Adenocarcinoma/diagnóstico , Hipertensão Pulmonar/etiologia , Neoplasias Pulmonares/complicações , Neoplasias Pulmonares/diagnóstico , Células Neoplásicas Circulantes , Embolia Pulmonar/etiologia , Adenocarcinoma/patologia , Diagnóstico Diferencial , Dispneia/etiologia , Evolução Fatal , Feminino , Humanos , Hipertensão Pulmonar/patologia , Neoplasias Pulmonares/patologia , Metástase Linfática , Pessoa de Meia-Idade , Embolia Pulmonar/patologia , Doença Cardiopulmonar/etiologia
11.
Orv Hetil ; 148(10): 457-63, 2007 Mar 11.
Artigo em Húngaro | MEDLINE | ID: mdl-17350912

RESUMO

In a retrospective study, the authors examined the occurrence of hydrops in foetal and neonatal cases in a five-year period. During this time, the clinical and pathologic diagnosis of hydrops was established in 28 cases. In three cases, the hydrops was caused by Rh incompatibility, and in 25 cases non-immune hydrops was discovered by clinical and pathologic examination. The cause of hydrops was recognised in 25 cases and no underlying disease was discernible in three. In 12 cases, the pregnancy was spontaneously terminated. Artificial abortion was performed in four cases. In this series, four hydropic newborns died on the first week of their life. The average age in artificial abortion was 16-20 gestational week and 24 in spontaneous abortion or stillbirth. Pathologic examination revealed increased weight, oedema, ascites, and hydrothorax in all cases. In half of the cases, there was also hydropericardium. Hepatosplenomegaly, cardiomegaly, pulmonary hypoplasia, increased extramedullary hemopoiesis, and placenta oedema were seen in all the cases. Causes of the non-immune hydrops were cardiac malformation in 4 cases, chromosome anomaly in 3, cystic hygroma in 2, skeletal anomaly in 1, foeto-foetal transfusion in 3, infection in 7 and sacrococcygeal teratoma in 1 case. In two cases, the underlying disease was reported to be of maternal origin. Comparing the clinical and pathologic findings there were only three cases with absolute agreement. The underlying disease revealed by pathologic examination was regarded to be significant from respect of inheritance, therapeutic approach, and further management in 10 cases. The authors emphasise the importance of pathologic examinations in foetal hydrops and point out the significance of clinico-pathological collaboration in the decision about further management of hydropic foetuses.


Assuntos
Hidropisia Fetal/diagnóstico , Hidropisia Fetal/etiologia , Aborto Induzido , Aborto Espontâneo , Autopsia , Feminino , Idade Gestacional , Humanos , Hungria/epidemiologia , Hidropisia Fetal/mortalidade , Recém-Nascido , Masculino , Gravidez , Diagnóstico Pré-Natal , Estudos Retrospectivos
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