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1.
J Curr Ophthalmol ; 34(1): 56-59, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35620375

RESUMO

Purpose: To analyze the biometric values and the prevalence of corneal astigmatism in cataract surgery candidates. Methods: This is a prospective study. Ocular biometric values and corneal keratometric astigmatism were measured by optical low-coherence reflectometry (Lenstar LS 900) before surgery in patients who were candidates for cataract extraction surgery. Descriptive measurements of biometric dimensions and keratometric cylinder data and their correlations with sex and age were evaluated. Results: Ocular biometric and keratometric values from 2084 eyes of 2084 patients (mean age 66.43, range 19-95 years) were analyzed. The mean values were as follows: corneal astigmatism 0.89 diopter (D), mean corneal keratometry 44.29 D, central corneal thickness 534 µ, internal anterior chamber depth (ACD) 3.11 mm, lens thickness 4.50 mm, and axial length 23.35 mm. Corneal astigmatism was <1.25 D in 1660 (79.5%) of eyes. Astigmatism was with-the-rule in 976 (46.8%) of eyes, against-the-rule (ATR) in 702 (33.7%), and oblique in 406 (19.5%). Analysis of corneal astigmatism revealed a change toward "ATR" with age which was not statistically significant. The ACD was correlated with age. The amount of corneal astigmatism had no correlation with age and sex. Conclusion: Corneal astigmatism was higher than 1.25 D in about 21% of cataract surgery candidates with slight differences between the various age ranges and had no correlation with age and sex.

2.
J Cataract Refract Surg ; 48(4): 508-512, 2022 04 01.
Artigo em Inglês | MEDLINE | ID: mdl-35318296

RESUMO

A 40-year-old woman was referred for the assessment of bilateral corneal opacities with gradual visual decline over the course of the past decade. Her past ocular history is significant for bilateral amblyopia and strabismus surgery in both eyes before age 5. The patient's parents were told by her childhood ophthalmologist that she had a hereditary disorder. Her systemic review was significant for anal fissure and human leukocyte antigen-B27 ankylosing spondylitis. Her past ocular record revealed corrected distance visual acuity (CDVA) of 20/80 in both eyes in 2018 with central corneal haze. On presentation, her uncorrected distance visual acuity was 20/150 in both eyes. Her CDVA was 20/100 in both eyes with manifest refraction of +0.50 -2.50 × 075 in the right eye and +5.00 -2.25 × 094 in the left eye. Corneal topography reflected keratometry of 35.75/38.97 × 171 in the right eye and 36.45/38.35 × 32 in the left eye. Central corneal thickness was 669 µm and 652 µm, respectively. External slitlamp examination revealed a central faint stromal opacity inferior to the visual axis in the right eye and a central faint stromal opacity in the left eye, and both were associated with steep posterior curvature of the cornea (Figure 1). Further findings included 0.5 corneal haze with mild guttata, normal irides, and clear lenses in both eyes. Intraocular pressure was 23 mm Hg and 26 mm Hg, respectively (Figure 2, Supplemental Figures 1 and 2, http://links.lww.com/JRS/A543). Gonioscopy was unremarkable. Dilated fundus examination revealed a 0.15 cup-to-disc ratio bilaterally, but otherwise no pertinent vitreoretinal pathologies were noted. What is the most likely diagnosis? What medical or surgical interventions would you recommend for this patient? What is the prognosis for this patient?


Assuntos
Córnea , Opacidade da Córnea , Adulto , Criança , Pré-Escolar , Topografia da Córnea , Feminino , Humanos , Pressão Intraocular , Iris , Refração Ocular , Acuidade Visual
3.
Surv Ophthalmol ; 67(2): 427-439, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-34157346

RESUMO

Erythropoietin (EPO) is a glycoprotein hormone that regulates hematopoiesis in the human body. The presence of EPO and its receptors in different tissues indicates that this hormone has extramedullary effects in other tissues, including the eye. We focus on the biological roles of this hormone in the development and normal physiologic functions of the eye. Furthermore, we explore the role of EPO in the management of different ocular diseases - including diabetic retinopathy, retinopathy of prematurity, inherited retinal degeneration, branch and central retinal vein occlusion, retinal detachment, traumatic optic neuropathy, optic neuritis, methanol optic neuropathy, nonarteritic anterior ischemic optic neuropathy, glaucoma, and scleral necrosis.


Assuntos
Eritropoetina , Oftalmopatias/tratamento farmacológico , Oftalmologia , Retinopatia Diabética , Eritropoetina/uso terapêutico , Humanos , Neuropatia Óptica Isquêmica , Oclusão da Veia Retiniana
4.
J Cataract Refract Surg ; 47(10): 1378-1379, 2021 10 01.
Artigo em Inglês | MEDLINE | ID: mdl-34544090
5.
Int J Ophthalmol ; 14(3): 356-365, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33747809

RESUMO

AIM: To compare the clinical outcomes of a variety of multifocal intraocular lenses (MIOLs) in patients diagnosed with presbyopia or cataracts. METHODS: This clinical trial study included 141 patients (282 eyes) with different MIOLs implantation. The Symfony (60 eyes), the ReSTOR (100 eyes), the AT LISAtri (60 eyes), and the PanOptix (62 eyes) intraocular lenses were evaluated in this prospective interventional study. The near, intermediate, and distant visual acuities, contrast sensitivity, and defocus curve were measured as valid criteria. To statistically analyze the results, we used the Statistical Package for Social Science software, the non-parametric Wilcoxon signed-rank t, the one-way analysis of variance and the Tukey's post-hoc test in our analysis. Moreover, we conducted a detailed literature search on the PubMed database in English about MIOLs, in total 59 studies were included in this review article. RESULTS: The four approaches did not show any significant difference in the best-corrected distance visual acuity (P>0.05). The defocus curves at the contrast of 100% showed that trifocal IOLs had better intermediate performance than the bifocal IOL (P<0.05). There were no statistically significant differences between AT LISAtri and PanOptix lenses for visual acuity at all distances. The eyes with PanOptix, Symfony, and AT LISAtri IOL showed better contrast sensitivity than those ReSTOR at spatial frequencies of 1, 3, and 6 cpd in photopic and mesopic conditions (P<0.001). CONCLUSION: All four groups of the multifocal lenses were satisfying in terms of distance and near vision. Also, the group of trifocal lenses led to satisfactory outcomes in intermediate vision, without degradation in quality of vision.

6.
Am J Ophthalmol ; 226: 13-21, 2021 06.
Artigo em Inglês | MEDLINE | ID: mdl-33529592

RESUMO

PURPOSE: To compare the outcomes of penetrating keratoplasty (PK) and deep anterior lamellar keratoplasty (DALK) for pediatric keratoconus. DESIGN: Retrospective comparative interventional case series. METHODS: This study included consecutive pediatric keratoconus cases (≤18 years of age) who received PK (n=45) or DALK (n=54) in 2 different time periods. Postoperative best spectacle-corrected visual acuity (BSCVA), refraction, and complications were compared between the study groups. RESULTS: The mean follow-up was 83.3±46.1 and 63.3±45.6 months in the PK and DALK groups, respectively (P = .10). Postoperatively, BSCVA was 0.20±0.19 logMAR in the PK group and 0.26±0.19 logMAR in the DALK group (P = .11), with a BSCVA of ≥20/40 in 91.1% and 83.3% of eyes, respectively (P = .25). Two groups were comparable regarding postoperative refractive outcomes. Graft epitheliopathy and suture-associated complications were more commonly encountered after DALK, which was attributable to the effect of low-quality grafts on the clinical outcomes of DALK. Ten PK eyes (22.2%) and 9 DALK eyes (16.7%) experienced at least 1 episode of graft rejection within 5 years of corneal transplantation (P = .49). Rejection was reversible in 93.1% and 100% of episodes in the PK and DALK groups, respectively (P = .63). At the postoperative year 5, 95.6% of grafts in the PK group and 98.2% in the DALK group remained clear (P = .45). CONCLUSION: No significant difference was observed in the outcomes between PK and DALK in pediatric keratoconus. Low-quality donor tissues in DALK increased the incidence of graft epithelial problems and suture-related complications as compared to PK.


Assuntos
Transplante de Córnea/métodos , Ceratocone/cirurgia , Ceratoplastia Penetrante/métodos , Adolescente , Criança , Topografia da Córnea , Feminino , Seguimentos , Rejeição de Enxerto/fisiopatologia , Humanos , Ceratocone/diagnóstico , Ceratocone/fisiopatologia , Masculino , Complicações Pós-Operatórias , Refração Ocular/fisiologia , Estudos Retrospectivos , Microscopia com Lâmpada de Fenda , Doadores de Tecidos , Resultado do Tratamento , Acuidade Visual/fisiologia
7.
Eye (Lond) ; 35(10): 2879-2888, 2021 10.
Artigo em Inglês | MEDLINE | ID: mdl-33414533

RESUMO

PURPOSE: To compare the efficacy of topical 0.03% tacrolimus in combination with systemic corticosteroids versus systemic mycophenolate mofetil (MMF) and corticosteroids in preventing corneal allograft rejection after repeat keratoplasty. METHODS: This prospective, randomized clinical trial enrolled 63 consecutive eyes of 63 patients who underwent repeat keratoplasty after a failed penetrating keratoplasty. Group 1 (32 eyes) received MMF orally 1 g twice daily for the first 6 months and then 1 g daily for the next 6 months, and group 2 (31 eyes) received topical 0.03% tacrolimus four times a day for 12 months. All patients were treated with topical and oral corticosteroids postoperatively. The participants were observed closely for signs of graft rejection, and the rates of rejection-free graft survival were calculated and compared between the two groups at postoperative month 12. RESULTS: The groups were balanced in patient's age and risk factors for graft rejection (e.g., original diagnosis, number of previous grafts, and quadrants of corneal vascularization). Endothelial graft rejection occurred in 5 eyes (15.6%) of group 1 and 6 eyes (19.4%) of group 2 (P = 0.75). Irreversible endothelial graft rejection resulting in graft failure occurred in 3 eyes of each group (P = 0.99). The rate of rejection-free graft survival was 84.4% in group 1 and 80.6% in group 2 at postoperative month 12 (P = 0.74). CONCLUSION: Topical 0.03% tacrolimus was as effective as systemic MMF as adjuncts to topical and systemic corticosteroids in reducing endothelial graft rejection with 12 months follow up after repeat keratoplasty.


Assuntos
Transplante de Córnea , Ácido Micofenólico , Corticosteroides , Rejeição de Enxerto/prevenção & controle , Humanos , Imunossupressores/uso terapêutico , Ácido Micofenólico/uso terapêutico , Estudos Prospectivos , Tacrolimo/uso terapêutico
8.
J Refract Surg ; 36(12): 786-794, 2020 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-33295990

RESUMO

PURPOSE: To investigate the potential benefit of keratoconus surgery using customized corneal stromal donor lenticules obtained from myopic small incision lenticule extraction (SMILE) surgery by femtosecond laser. METHODS: In this prospective, consecutive, non-comparative series of cases, 22 lenticules were obtained from 22 myopic patients who had SMILE with a lenticule central thickness of greater than 110 µm. The lenticules were implanted in 22 eyes with advanced keratoconus. The lenticules were customized for the purpose of the implantation with either a simple necklace or necklace-with-ring shape (compound form) depending on the corneal thickness and corneal topography configuration of the implanted keratoconic eyes. The lenticules were implanted into a 9.5-mm corneal lamellar pocket created by the femtosecond laser. Changes in densitometry, thickness, confocal microscopy, corrected distance visual acuity (CDVA), and endothelial cell density were investigated. RESULTS: Intrastromal lenticule implantation was successfully performed in all cases without any complication. Corneal thickness showed a mean enhancement of 100.4 µm at the thinnest point. On biomicroscopy, all corneas were clear at 1 year postoperatively and there was a significant improvement in corneal densitometry during the entire follow-up period. Confocal biomicroscopy showed collagen reactivation without any inflammatory features caused by the implanted fresh lenticules. CDVA improved from 0.70 to 0.49 logMAR (P = .001) and keratometry decreased from 54.68 ± 2.77 to 51.95 ± 2.21 diopters (P = .006). CONCLUSIONS: Customized SMILE lenticule implantation by femtosecond laser proved to be feasible, resulting in an improvement in vision, topography, and refraction in the implanted eyes. [J Refract Surg. 2020;36(12):786-794.].


Assuntos
Cirurgia da Córnea a Laser , Ceratocone , Substância Própria , Topografia da Córnea , Humanos , Ceratocone/cirurgia , Estudos Prospectivos , Refração Ocular , Tomografia de Coerência Óptica
9.
Br J Ophthalmol ; 104(11): 1621-1628, 2020 11.
Artigo em Inglês | MEDLINE | ID: mdl-31420327

RESUMO

BACKGROUND/AIMS: SLC4A11 is the only known causative gene of congenital hereditary endothelial dystrophy (CHED). Mutation screenings have shown that most but not all patients with CHED harbour mutations in SLC4A11, suggesting that other CHED-causing genes may exist. We aimed to screen SLC4A11 in Iranian patients to learn the mutation spectrum of this gene among Iranians and to gain further knowledge on potential contribution of other genes to CHED aetiology. METHODS: SLC4A11 was screened in 21 Iranian patients with CHED by sequencing. Previously unreported variations were checked in at least 200 controls, and segregation analysis within families and bioinformatics predictions on effects of variations were performed. Exome sequencing was done for the single patient without an SLC4A11 mutation and for her parents. RESULTS: Nine previously reported and 10 unreported SLC4A11 mutations were observed among 20 patients; a mutation was not found in one patient. A mutation in MPDZ was identified as the only candidate cause of CHED in this patient. Her mother who carried the same mutation was diagnosed with Fuchs endothelial corneal dystrophy (FECD). CONCLUSION: SLC4A11 mutations are the usual cause of CHED in Iranians. The 10 novel mutations observed contribute significantly to the approximately 85 mutations reported since discovery of the role of the gene in CHED pathogenesis more than 10 years ago. MPDZ mutations may be a cause of CHED and even FECD in a minority of patients. Proposed functions of MPDZ with respect to tight junctions and maintenance of the corneal endothelial barrier are in accordance with a role in corneal endothelial pathobiology.


Assuntos
Proteínas de Transporte de Ânions/genética , Antiporters/genética , Distrofias Hereditárias da Córnea/genética , Distrofia Endotelial de Fuchs/genética , Proteínas de Membrana/genética , Mutação , Polimorfismo de Nucleotídeo Único/genética , Códon sem Sentido/genética , Consanguinidade , Distrofias Hereditárias da Córnea/diagnóstico , Análise Mutacional de DNA , Exoma/genética , Feminino , Mutação da Fase de Leitura/genética , Distrofia Endotelial de Fuchs/diagnóstico , Humanos , Íntrons/genética , Irã (Geográfico) , Masculino , Mutação de Sentido Incorreto/genética , Linhagem
10.
J Cataract Refract Surg ; 45(4): 530-531, 2019 04.
Artigo em Inglês | MEDLINE | ID: mdl-30947858
11.
J Ophthalmic Vis Res ; 14(1): 101-104, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30820295

RESUMO

Purpose: To report visual rehabilitation with a native Pintucci keratoprosthesis (KPro) after a severe ocular surface chemical burn in a male patient. Case Report: A 41-year-old man experienced a bilateral severe chemical burn 5 years previously. Earlier penetrating keratoplasty and keratolimbal allografts were unsuccessful in both eyes, and neither of the eyes had vision better than light perception. Both corneas were opaque and conjunctivalized. Because of severe dry eye and total limbal stem cell deficiency, the left eye was considered for a Pintucci-type KPro. In the first stage, the ocular surface was reconstructed with an oral mucus membrane graft, and a KPro was placed under the skin and orbicularis oculi muscle. Three months later, the KPro was removed and implanted in the left eye. During seven months after the KPro implantation, the anatomical position was acceptable, and his best corrected visual acuity was 2/10. Conclusion: Bearing in mind the successful results of the native Pintucci KPro in this case of severe acid burn, using this type of keratoprosthesis in patients with total limbal stem cell deficiency and severe dry eye is recommended.

12.
Cornea ; 38(1): 35-41, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30273193

RESUMO

PURPOSE: To evaluate the geometry of donor corneal buttons after mechanical trephination and to determine whether there were any possible variables that could influence the accuracy of cutting corneal buttons in deep anterior lamellar keratoplasty. METHODS: This cross-sectional study included 85 sclerocorneal buttons that were transplanted during deep anterior lamellar keratoplasty. Donor corneas were punched from the posterior surface. Photographs that most clearly represented the entire edges of the donor corneas were taken from the punched corneas and systematically analyzed using ImageJ software. The univariate analyses were used to investigate the influence of potential variables on the precision and roundness of the donor cut. RESULTS: The epithelial side of the grafts was significantly larger than the posterior side in diameter, perimeter, and area. The perimeter and area of the donor posterior surface and the trephine used for punching the grafts were the same, whereas the epithelial side had a significantly larger perimeter and area than those of the trephine. Graft roundness varied from 0.78 to 1.0 at the epithelial side and from 0.77 to 1.0 at the posterior side. The roundness of the scleral spur, which represented the shape of the donor cornea, was identified as the main predictor of the roundness of the donor cut (P < 0.001). CONCLUSIONS: The donor buttons after mechanical trephination from the posterior surface may not be circular and of the intended diameter; the epithelial surface dimensions were significantly larger than the posterior surface and trephine dimensions. The roundness of the punched graft was primarily affected by the roundness of the cornea before trephination.


Assuntos
Córnea/diagnóstico por imagem , Endotélio Corneano/ultraestrutura , Ceratocone/cirurgia , Ceratoplastia Penetrante/métodos , Propriedades de Superfície , Doadores de Tecidos , Adolescente , Adulto , Idoso , Criança , Pré-Escolar , Estudos Transversais , Endotélio Corneano/transplante , Feminino , Humanos , Ceratocone/patologia , Masculino , Microscopia Eletrônica de Varredura , Pessoa de Meia-Idade , Estudos Retrospectivos , Adulto Jovem
14.
J Ophthalmic Vis Res ; 13(2): 93-100, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29719635

RESUMO

Purpose: To compare mean posterior corneal power and astigmatism in normal versus keratoconus affected eyes and determine the optimal cut-off points to maximize sensitivity and specificity in discriminating keratoconus from normal corneas. Methods: A total of 204 normal eyes and 142 keratoconus affected eyes were enrolled in this prospective comparative study. Mean posterior corneal power and astigmatism were measured using a dual Scheimpflug camera. Correlation coefficients were calculated to assess the relationship between the magnitudes of keratometric and posterior corneal astigmatism in the study groups. Receiver operating characteristic curves were used to compare the sensitivity and specificity of the measured parameters and to identify the optimal cut-off points for discriminating keratoconus from normal corneas. Results: The mean posterior corneal power was -6.29 ± 0.20 D in the normal group and -7.77 ± 0.87 D in the keratoconus group (P < 0.001). The mean magnitudes of the posterior corneal astigmatisms were -0.32 ± 0.15 D and -0.94 ± 0.39 D in the normal and keratoconus groups, respectively (P < 0.001). Significant correlations were found between the magnitudes of keratometric and posterior corneal astigmatism in the normal (r=-0.76, P < 0.001) and keratoconus (r=-0.72, P < 0.001) groups. The mean posterior corneal power and astigmatism were highly reliable characteristics that distinguished keratoconus from normal corneas (area under the curve, 0.99 and 0.95, respectively). The optimal cut-off points of mean posterior corneal power and astigmatism were -6.70 D and -0.54 D, respectively. Conclusion: Mean posterior corneal power and astigmatism measured using a Galilei analyzer camera might have potential in diagnosing keratoconus. The cut-off points provided can be used for keratoconus screening.

16.
J Cataract Refract Surg ; 43(10): 1360-1361, 2017 10.
Artigo em Inglês | MEDLINE | ID: mdl-29120725
17.
J Ophthalmic Vis Res ; 12(3): 265-269, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28791058

RESUMO

PURPOSE: To determine changes in stereoacuity in anisometropic myopic eyes after photorefractive keratectomy (PRK). METHODS: Myopic patients with at least 1 diopter (D) of anisometropia in sphere, astigmatism, or spherical equivalent who were referred to our hospital for excimer refractive surgery were enrolled as a prospective sequential interventional case series. All patients underwent wavefront-guided photorefractive keratectomy (WFG-PRK) using the Technolas Perfect Vision (217z) Excimer laser machine. Changes in binocular stereoacuity were evaluated using the TNO and Butterfly stereoacuity tests before and at 2 weeks, 1 month, and 3 months after the operation. RESULTS: Between January and November 2015, a total of 98 eyes of 49 patients (71.4% men) with a mean age of 28 ± 5.5 years, mean myopia of -3.32 ± 1.74 D, and mean astigmatism of 1.3 ± 1.3 D were enrolled in this study. Preoperative mean stereoacuity values were 102 ± 103.44 and 56.8 ± 41 seconds of arc (s/arc)as measured by the TNO and Butterfly stereoacuity tests. Mean stereoacuity improved to 90 ± 110.52 s/arc (P = 0.009) and 56.5 ± 41.3 s/arc (P = 0.80), respectively, 6 months after WFG-PRK. Overall improvement in stereoacuity was 10.2% and 6.12% according to the TNO and Butterfly stereoacuity tests, respectively. CONCLUSION: Stereoacuity improves after WFG-PRK for treatment of anisometropic myopia. This improvement is more accurately detectable by the TNO than the Butterfly stereoacuity test.

18.
J Ophthalmic Vis Res ; 12(1): 11-16, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28299001

RESUMO

PURPOSE: To compare the efficacy and side effects of loteprednol versus fluorometholone after myopic photorefractive keratectomy (PRK). METHODS: One hundred and twenty four eyes of 62 patients who underwent PRK were enrolled in this study. One eye of each subject was randomized to receive loteprednol 0.5% and the fellow eye was given fluorometholone 0.1%. Patients were followed up for three months. RESULTS: There was no significant difference in uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), manifest refraction, corneal haze, intraocular pressure (IOP), and ocular discomfort and redness between groups at the final visit. At 3 months postoperatively, 20/25 or better UDVA was achieved in 95% of the loteprednol group and 92% of the fluorometholone group (P > 0.05). There was neither visually significant corneal haze nor ocular hypertension (IOP rise > 10 mmHg or IOP > 21 mmHg) in any group. CONCLUSION: The efficacy and side effects of loteprednol 0.5% and fluorometholone 0.1% after myopic PRK are comparable.

19.
J Ophthalmic Vis Res ; 12(1): 23-29, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28299003

RESUMO

PURPOSE: To compare the anterior segment indices measured by two Scheimpflug camera machines; Galilei and Pentacam. METHODS: In this observational case series, the anterior segment indices of myopic healthy subjects seeking for refractive surgery were measured by Pentacam and Galilei on the same day. Analyzed parameters were anterior and posterior best fit spheres (BFS), axial curvature, true corneal power, central corneal thickness (CCT), anterior chamber (AC) depth, AC volume, AC angle, and pupil diameter. RESULTS: This study included 176 eyes of 88 participants. Mean radius of the anterior BFS was 7.79 ± 0.34 mm versus 7.75 ± 0.39 mm measured by Pentacam and Galilei, respectively (r = 0.877, P < 0.001). Corresponding values for the mean radius of posterior BFS were 6.42 ± 0.32 and 6.47 ± 0.38 mm, respectively (r = 0.879, P < 0.001). Anterior corneal mean power was 43.8 ± 1.9 diopters (D) with Pentacam and 43.8 ± 2.4 D with Galilei (r = 0.905,P < 0.001). Posterior corneal mean power was measured - 6.3 ± 0.3 and - 6.3 ± 0.4 D using Pentacam and Galilei, respectively (r = 0.873, P < 0.001). True corneal power was 43.9 ± 1.9 D with Pentacam and 43.5 ± 2.3 D with Galilei (r = 0.909, P < 0.001). CCT was 537 ± 44 and 553 ± 51 µm measured by Pentacam and Galilei, respectively (r = 0.796, P < 0.001). AC depth measurements using Pentacam and Galilei were 3.29 ± 0.4 and 3.3 ± 0.38 mm (P < 0.001), respectively; AC volume was 207 ± 50 and 129 ± 39 mm3≥ (P = 0.004), and AC angle was 39.7 ± 9.2 and 54.2 ± 5.2 degrees (P = 0.051), respectively. Average pupil diameter was measured 3.91 ± 1.77 mm by Pentacam and 3.34 ± 0.89 mm by Galilei (P = 0.018). CONCLUSIONS: There was a significant correlation between the Pentacam and Galilei in all measured parameters except AC angle, AC volume, and average pupil diameter.

20.
J Cataract Refract Surg ; 43(12): 1534-1540, 2017 12.
Artigo em Inglês | MEDLINE | ID: mdl-29335097

RESUMO

PURPOSE: To compare the refractive and higher-order aberrations (HOAs) outcomes after photorefractive keratectomy (PRK) in patients with significant astigmatism using aspheric versus wavefront-guided aspheric profiles. SETTING: Ophthalmic Research Center and Department of Ophthalmology, Shahid Beheshti University of Medical Sciences, Negah Eye Hospital, Tehran, Iran. DESIGN: Prospective randomized case series. METHODS: One eye of each patient with a refractive astigmatism more than 2.00 diopters (D) randomly received aspheric PRK. In the other eye, wavefront-guided and aspheric treatment was performed using a personalized treatment advanced algorithm. Visual acuity, refractive errors, and HOAs were compared between the 2 groups preoperatively and 12 months postoperatively. RESULTS: The study comprised 32 patients (64 eyes). The mean preoperative refractive astigmatism was -4.07 D ± 1.64 (SD) and -4.02 ± 1.55 D in the aspheric group and wavefront-guided aspheric group, respectively (P = .2). The mean postoperative astigmatism was -0.46 ± 0.37 D and -0.82 ± 0.53 D in the aspheric group and wavefront-guided aspheric group, respectively (P = .02). Postoperatively, the root mean square of total HOAs was significantly increased in both groups. However, compared with wavefront-guided aspheric PRK, aspheric PRK induced fewer HOAs (P = .003). CONCLUSIONS: In eyes with high astigmatism, post-PRK residual astigmatism was lower in the aspheric group than in the wavefront-guided aspheric group. The increase in HOAs was significantly higher in the wavefront-guided aspheric group than in the aspheric group.


Assuntos
Astigmatismo , Ceratectomia Fotorrefrativa , Astigmatismo/cirurgia , Humanos , Período Pós-Operatório , Estudos Prospectivos , Acuidade Visual
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