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2.
J Urol ; 206(6): 1361-1372, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-34288714

RESUMO

PURPOSE: Ejaculatory dysfunction (EjD) and erectile dysfunction after cancer treatment are clinically important complications, but their exact prevalence by various kinds of cancer site and type of treatment is unknown. The aim of this systematic review and meta-analysis was to examine the available evidence and provide pooled estimates for prevalence of EjD and erectile dysfunction in relation to all cancer sites and identify characteristics associated with EjD in cancer patients. MATERIALS AND METHODS: We performed a systematic review and meta-analysis of cross-sectional and case-control studies. We searched 4 electronic databases (Medline®, CINAHL, PsychInfo and Embase®) until July 22, 2020. All retrospective or prospective studies reporting the prevalence of EjD in male patients with cancer were included in this review. A random effects meta-analysis was conducted calculating prevalence proportions with 95% confidence intervals. Prevalence proportions were calculated for the incidences of EjD by cancer site and type of treatment. RESULTS: A total of 64 studies (a total of 10,057 participants) were included for analysis. The most common cancer sites were bladder, colon, testis and rectum. The prevalence rates of EjD after surgical intervention ranged from 14.5% (95% CI 2.2-56.3) in colon cancer to 53.0% (95% CI 23.3-80.7) in bladder cancer. The prevalence rates of erectile dysfunction ranged from 6.8% (95% CI 0.8-39.1) in bladder cancer to 68.7% (95% CI 55.2-79.6) in cancer of the rectum. CONCLUSIONS: In a large study-level meta-analysis, we looked at a high prevalence of EjD and erectile dysfunction at various cancer sites and across different treatment types. Prospective studies of EjD and erectile dysfunction after various kinds of cancer treatments are warranted.

3.
Int J Clin Pract ; 75(3): e13766, 2021 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-33074558

RESUMO

AIMS: To evaluate the diagnostic significance of the novel index combining preoperative haemoglobin, albumin levels, lymphocyte and platelet counts (HALP) in prostate cancer (PCa) patients. METHODS: Between 1 January 2015 to 31 December 2018 at the Hitit University Erol Olçok Education and Research Hospital 225 patients who had undergone transrectal ultrasound guided prostate biopsy or prostate surgery were analysed retrospectively. A total of patients, 155 had benign prostate hyperplasia (group 1) and 70 had PCa (group 2). The preoperative serum levels of haemoglobin, albumin, lymphocyte counts and platelet counts were recorded. The HALP scores and the sub-parameters of this index for each of the two groups were compared. RESULTS: The total Prostate-Specific Antigen (PSA), albumin and lymphocyte differences between the groups were statistically significant (P = 0.0002, P = 0.0001, P = 0.005). The median value of HALP scores in Group 1 and 2 were 49.43 and 51.2, respectively, and this was not statistically significant between groups (P =0 .737). The HALP score had the least Area Under Curve (AUC) value compared with the others (0.514). The AUC of Albumin was larger than PSA for diagnostic efficacy in PCa patients (0.696-0.656). However, albumin levels were statistically significant compared with platelet count and the HALP score (P = 0.0033, P = 0.0068), except PSA and lymphocyte (P = 0.4580, P =0 .1717). CONCLUSION: Further prospective clinical studies that include more patients from multiple centres are needed to show the diagnostic role of the HALP score and its compounds on the patients with PCa.


Assuntos
Plaquetas , Neoplasias da Próstata , Albuminas , Plaquetas/química , Plaquetas/patologia , Hemoglobinas , Humanos , Hiperplasia/patologia , Linfócitos , Masculino , Contagem de Plaquetas , Prognóstico , Antígeno Prostático Específico , Neoplasias da Próstata/diagnóstico , Estudos Retrospectivos
4.
Int J Clin Pract ; 75(3): e13850, 2021 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-33222353

RESUMO

AIM: To show if lower urinary tract symptoms (LUTS) could be symptoms of COVID-19 with validated questionnaires. METHODS: The 96 COVID-19 patients who were hospitalised at a tertiary centre were collected retrospectively. After the exclusion criteria, 46 patients consisted the study population. All patients then fill formed the International Prostate Symptom Score and Urinary Symptom Profile respectively. All patients responded to these questions for the three period. RESULTS: Twenty-seven female (58.6%) and 19 male (41.4%) COVID-19 patients answered the questions. In the male patients, while there were no statistically significant differences in the total IPSS, the voiding IPSS score, and quality of life between the three periods (P = .148; P = .933, P = .079, respectively), the storage IPSS scores had a significant difference between the three periods (P = .05). In female patients, low stream scores were similar between the three periods (P = .368). The scores of stress incontinence and an overactive bladder had a significant difference between the three periods (P = .05 and P = .05). CONCLUSION: LUTS, especially storage symptoms, might be one of the initial symptoms of COVID-19 and the clinicians should evaluate LUTS with other known symptoms of the virus when a patient is suspected of having COVID-19.


Assuntos
COVID-19 , Sintomas do Trato Urinário Inferior , Feminino , Humanos , Sintomas do Trato Urinário Inferior/diagnóstico , Masculino , Qualidade de Vida , Estudos Retrospectivos , SARS-CoV-2
5.
Int J Clin Pract ; 75(3): e13923, 2021 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-33300261

RESUMO

OBJECTIVE: To investigate the effect of COVID-19 on sexual dysfunction in women. MATERIAL AND METHODS: The women diagnosed with COVID-19 and hospitalised at a tertiary hospital were included. They completed the Introductory Data Form, the Female Sexual Function Index-(FSFI) and the Short Form-36 Quality of Life Scale (SF-36). RESULTS: Fifteen women between the ages of 19-49 who completed the treatment protocol, discharged at least 14 days before and who had not been diagnosed as sexual dysfunction; sexually active earlier were included in the study. It was detected that weekly sexual intercourse before and after COVID-19 significantly differed (P = .047). The frequency of relationships decreased statistically after COVID-19. The mean value of the FSFI satisfaction score differs from COVID-19 before and after diagnosis (P = .012). The mean satisfaction score before COVID-19 was 3.47, and after COVID-19 was 2.93. The score of the subgroups of FSFI did not differ from COVID-19 before and after diagnosis (P > .050). The median value of SF-36 pain differs from COVID-19 before and after diagnosis (P = .008). CONCLUSION: It was concluded that the frequency of sexual intercourse and sexual satisfaction in women decreased after COVID-19 disease, and the quality of life scores did not change in a statistically significant way.


Assuntos
COVID-19 , Adulto , Feminino , Humanos , Pessoa de Meia-Idade , Qualidade de Vida , SARS-CoV-2 , Comportamento Sexual , Inquéritos e Questionários , Adulto Jovem
6.
Int J Clin Pract ; 75(4): e13735, 2021 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-32996259

RESUMO

OBJECTIVE: To present a nation-wide analysis of the workload of urology departments in Turkey week-by-week during Covid-19 pandemic. METHODOLOGY: The centres participating in the study were divided into three groups as tertiary referral centres, state hospitals and private practice hospitals. The number of outpatients, inpatients, daily interventions and urological surgeries were recorded prospectively between 9-March-2020 and 31-May-2020. All these variables were recorded for the same time interval of 2019 as well. The weekly change of the workload of urology during pandemic period was evaluated, also the workload of urology and the distributions of certain urological surgeries were compared between the pandemic period and the same time interval of the year 2019. RESULTS: A total of 51 centres participated in the study. The number of outpatients, inpatients, urological surgeries and daily interventions were found to be dramatically decreased by the 3rd week of pandemics in state hospitals and tertiary referral centres; however, the daily urological practice were similar in private practice hospitals throughout the pandemic period. When the workload of urology in pandemic period and the same time interval of the year 2019 were compared, a huge decrease was observed in all variables during pandemic period. However, temporary measures like ureteral stenting, nephrostomy placement and percutaneous cystostomy have been found to increase during Covid-19 pandemic compared with normal life. CONCLUSIONS: Covid-19 pandemic significantly affected the routine daily urological practice likewise other subspecialties and priority was given to emergent and non-deferrable surgeries by urologists in concordance with published clinical guidelines.


Assuntos
COVID-19 , Urologia , Humanos , Pandemias , SARS-CoV-2 , Turquia/epidemiologia
7.
Rev. int. androl. (Internet) ; 18(2): 63-67, abr.-jun. 2020. tab
Artigo em Inglês | IBECS | ID: ibc-193761

RESUMO

INTRODUCTION AND OBJECTIVES: To evaluate the quality of information in You Tube videos pertaining to premature ejaculation. MATERIALS AND METHODS: A search for "premature ejaculation" (PE) was performed on You Tube in August 2018. Two senior urologist viewers watched and categorized each video for their sources, suggestions and information contents (excellent, fair or poor). RESULTS: Of the three hundred videos viewed on You Tube, 155 videos were included and analyzed. Mean video length (mean±standard deviation) was 3.08±2.02min. The information content was excellent only in 17 (10.9%) of all videos while for a majority of them it was poor (57.4% n=89). Fair videos constituted 31.7% (n=49) of the videos. There was no relation between the trustworthiness of the videos' contents and either their viewings or ratings (p = 0.561, p = 0.0966, respectively). Videos uploaded by health professionals were more reliable than those uploaded by laypersons (p < 0.001). CONCLUSIONS: The study suggests that although some videos, especially those uploaded by healthcare professionals, are useful; the majority of them have misleading information. Therefore, they are not a reliable source of PE information for PATIENTS: It is incumbent on urologists to counsel patients for other available useful internet information sources on PE


INTRODUCCIÓN Y OBJETIVOS: Evaluar la calidad de la información de los vídeos de YouTube relacionados con la eyaculación precoz (EP). MATERIALES Y MÉTODOS: Se realizó una búsqueda en YouTube sobre EP en agosto de 2018. Dos urólogos con experiencia vieron y clasificaron cada vídeo por sus fuentes, sugerencias y contenido científico (excelente, aceptable o deficiente). RESULTADOS: De los 300 vídeos vistos en YouTube, se incluyeron y analizaron 155 vídeos. La duración media del vídeo (media±desviación estándar) fue de 3,08±2,02min. El contenido científico fue excelente solo en 17 (10,9%) de todos los vídeos, mientras que en la mayoría de ellos esta fue deficiente (57,4%; n=89). Los vídeos aceptables constituyeron el 31,7% (n=49). No hubo relación entre la fiabilidad de los contenidos de los vídeos y el número de visualizaciones o las valoraciones de los usuarios (p = 0,561; p = 0,0966, respectivamente). Los vídeos subidos por profesionales sanitarios fueron más fiables que los subidos por profanos (p < 0,001). CONCLUSIONES: El estudio sugiere que, aunque algunos vídeos, especialmente aquellos publicados por profesionales sanitarios, son útiles, la mayoría de ellos contienen información engañosa. Por tanto, no son una fuente fiable de información sobre la EP para los pacientes. Les corresponde a los urólogos aconsejar a los pacientes sobre otras fuentes de información disponibles en Internet que resulten útiles


Assuntos
Humanos , Masculino , Ejaculação Precoce , Webcasts como Assunto/instrumentação , Recursos Audiovisuais/estatística & dados numéricos , Conhecimentos, Atitudes e Prática em Saúde , Webcasts como Assunto/estatística & dados numéricos
8.
Curr Med Imaging Rev ; 16(1): 80-87, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31989897

RESUMO

BACKGROUND: Our aim was to detect the role of radiological abdominal fat parameters by tomography and stone density by plain X-ray on extracorporeal Shock Wave Lithotripsy (SWL) stone-free rate. METHODS: The patients who had undergone SWL for a single opaque renal stone < 2 cm in diameter and proximal ureteric stone < 1 cm in diameter were collected retrospectively. The characteristics of patients and stones were recorded. The stone attitude, HU, abdominal fat parameters, paraperirenal fat area, perirenal infiltration and severity of hydronephrosis with pre-treatment Non- Contrast Computed Tomography (NCCT) and stone density with radiography were evaluated by a radiologist. Four weeks after the last SWL; all patients were evaluated by plain X-ray and categorized as Stone Free (SF) and Residual Fragment (RF) group. RESULTS: 51 patients with renal stones and 88 patients with proximal ureteral stones were included in the study. 24 (47%) and 63 (71%) patients were classified as SFfor renal and ureteral stones respectively. Only stone size was an independent predictor for stone-free rates after SWL for renal and proximal ureteral stones on multivariate analysis. The Receiver Operating Characteristic (ROC) curves for renal calculi revealed that creatinine level, stone size, stone attitude, Houns-Field Unit (HU) and Skin-to-Stone Distance (SSD) were the predictive factors for the SWL outcome (p< 0.05). The ROC curve for ureteral calculi demonstrated that HU, stone size and attitude were the predictive factors (p< 0.05). CONCLUSION: All abdominal fat parameters and the stone density were not related to SWL failure. A large follow-up with more patients is essential to confirm the role of radiological parameters on the outcome of SWL.


Assuntos
Gordura Abdominal/diagnóstico por imagem , Cálculos Renais/diagnóstico por imagem , Cálculos Renais/terapia , Litotripsia , Tomografia Computadorizada por Raios X , Adulto , Feminino , Humanos , Masculino , Valor Preditivo dos Testes , Radiografia Abdominal , Falha de Tratamento
9.
Rev Int Androl ; 18(4): 151-158, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31953028

RESUMO

INTRODUCTION AND OBJECTIVES: To examine the association between lifestyle factors (body mass index, smoking, alcohol consumption, coffee intake, physical activity, sauna and cell phone usage, wearing tight-fitting underwear), and conventional semen parameters. MATERIALS AND METHODS: 1311 participants who attended the Andrology Clinic were included in the study. All participants were separated into two groups as men with normozoospermia and dysspermia. All participants answered a questionnaire which contains questions about the modifiable lifestyle factors. The total risk scores were calculated after all the positive lifestyle factors had been counted. RESULTS: Men with normozoospermia and dysspermia consisted of 852 (65.0%) and 459 (35.0%) participants respectively. A negative relationship between the wearing of tight underwear and having normal semen parameters was detected between the two groups (p=0.004). While going to a sauna regularly was negatively related to semen concentration, wearing tight underwear was also related to both lower motility, normal morphology as well as semen concentration (p<0.05). While the total score of all participants was 5.22±1.34 point, there were no statistical differences between the two groups (p=0.332). It was found that having 3 more or fewer points was not related to any type of semen parameters and results of a spermiogram. CONCLUSION: The clinicians should give advice to infertile male patients about changing their risky lifestyle, for infertility, to a healthy lifestyle for fertility. Better designed studies, with larger sample sizes using conventional semen analysis with sperm DNA analysis methods, should be planned to identify the possible effects of lifestyle factors on semen quality.


Assuntos
Estilo de Vida , Sêmen/fisiologia , Espermatozoides/fisiologia , Adulto , Índice de Massa Corporal , Vestuário , Humanos , Masculino , Análise do Sêmen , Contagem de Espermatozoides , Motilidade Espermática/fisiologia , Espermatozoides/patologia , Banho a Vapor/efeitos adversos , Inquéritos e Questionários , Adulto Jovem
10.
Rev Int Androl ; 18(2): 63-67, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31000448

RESUMO

INTRODUCTION AND OBJECTIVES: To evaluate the quality of information in You Tube videos pertaining to premature ejaculation. MATERIALS AND METHODS: A search for "premature ejaculation" (PE) was performed on You Tube in August 2018. Two senior urologist viewers watched and categorized each video for their sources, suggestions and information contents (excellent, fair or poor). RESULTS: Of the three hundred videos viewed on You Tube, 155 videos were included and analyzed. Mean video length (mean±standard deviation) was 3.08±2.02min. The information content was excellent only in 17 (10.9%) of all videos while for a majority of them it was poor (57.4% n=89). Fair videos constituted 31.7% (n=49) of the videos. There was no relation between the trustworthiness of the videos' contents and either their viewings or ratings (p=0.561, p=0.0966, respectively). Videos uploaded by health professionals were more reliable than those uploaded by laypersons (p<0.001). CONCLUSIONS: The study suggests that although some videos, especially those uploaded by healthcare professionals, are useful; the majority of them have misleading information. Therefore, they are not a reliable source of PE information for patients. It is incumbent on urologists to counsel patients for other available useful internet information sources on PE.


Assuntos
Comportamento de Busca de Informação , Internet/normas , Ejaculação Precoce , Gravação em Vídeo/normas , Humanos , Disseminação de Informação/métodos , Internet/estatística & dados numéricos , Masculino , Educação de Pacientes como Assunto/métodos , Educação de Pacientes como Assunto/normas , Mídias Sociais/normas , Mídias Sociais/estatística & dados numéricos , Gravação em Vídeo/estatística & dados numéricos
11.
Int J Reprod Biomed ; 17(4)2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-31435606

RESUMO

Background: Cyclophosphamide (CP) is a well-known alkylating anticancer agent used in the treatment of various malignant and non-malignant tumors. CP may also cause a variety of adverse effects, including reproductive toxicity. Amifostine is known as a cytoprotective drug having antioxidant properties. Objective: To evaluate the possible beneficial effects of amifostine on testicular toxicity induced by CP in rats. Materials and Methods: A total of 35 Sprague-Dawley rats were used in this experimental study. The CP group animals received a single dose of 200 mg/kg CP on Day 8 by intraperitoneal injection and were left untreated for the following seven days. The two remaining groups of animals were treated with 200 mg/kg/day amifostine (AMF 200) and 400 mg/kg/day amifostine (AMF 400) for seven days prior to and following a single intraperitoneal injection of CP. Morphometrical analysis and histological examination of testicular tissue were performed. Serum testosterone, luteinizing hormone, and follicle-stimulating hormone levels were measured in serum using commercial ELISA kits. The epidydimal sperm count was determined. Results: The tubular epithelial height in the testis was significantly higher in the AMF400 group compared to other groups (p < 0.001). Animals in the AMF400 group showed minimal debris in the tubules, no Sertoli cell damage, and the Johnsen scores were slightly higher in the AMF400 group. The epididymal sperm count was significantly lower in the CP-administered animals compared to the control animals and was significantly higher in the AMF200 and AMF400 groups compared to the CP group (p = 0.006, and p = 0.019 respectively). Conclusion: Amifostine, at a dose of 400 mg/kg, may have a protective effect on testicular damage induced by CP in rats.

12.
Ren Fail ; 38(8): 1249-55, 2016 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-27435174

RESUMO

AIM: Contrast medium-induced nephropathy is one of the major complications of intravenous contrast medium use. But its pathogenesis is unclear. Epithelial mesenchymal transition (EMT) is defined as the transformation of the primer epithelial cells to mesenchymal cells. EMT in tubular cells might cause tubulointerstitial damage. In this study, we investigated whether or not EMT has a role in radiocontrast-induced nephropathy. Radiocontrast medium might be triggering reversible EMT via serum and glucocorticoid-regulated kinase 1 (SGK 1). We investigated the effect of different concentrations of the contrast agent iopromide on human proximal tubule cell (HK-2) culture by measuring the level of SGK1, snail family zinc finger 1 (SNAIL1), connective tissue growth factor (CTGF), and collagen type I alpha 1 (COL1A1). METHODS: We conducted a scratch assay and qPCR. HK-2 cells were cultured in the petri dishes/flasks and starved with serum-free medium. The 40, 20, and 10 mg/mL doses of iopromide were administrated to cells. The scratches were photographed immediately and again at the 20th hour. The levels of gene expression of SGK1, SNAIL1, CTGF, and COL1A1 were measured using the real-time qPCR system at the end of the 24th hour. RESULTS: Iopromide caused the breaking of intercellular connections, the disappearance of the cobblestone appearance of cells, and the migration of cells at the 20th hour in the scratch assay. It also increased the expression of SGK1, SNAIL1, CTGF, and COL1A1 genes. CONCLUSION: Our study concluded that certain important markers of EMT increase in different concentrations of the contrast agent. High osmolality might trigger EMT. The relationship between contrast agent and EMT has not been defined before. Further in vivo and in vitro studies are required.


Assuntos
Meios de Contraste/efeitos adversos , Transição Epitelial-Mesenquimal/genética , Iohexol/análogos & derivados , Nefropatias/induzido quimicamente , Nefropatias/metabolismo , Túbulos Renais Proximais/metabolismo , Diferenciação Celular , Linhagem Celular , Colágeno Tipo I/genética , Fator de Crescimento do Tecido Conjuntivo/genética , Humanos , Proteínas Imediatamente Precoces/genética , Iohexol/efeitos adversos , Fatores de Transcrição da Família Snail/genética
13.
Low Urin Tract Symptoms ; 8(1): 49-54, 2016 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-26789543

RESUMO

OBJECTIVE: The objective of the present study was to examine the relationship between work-related factors and lower urinary tract symptoms (LUTS) and to emphasize the vicious circle between symptoms and work conditions. METHODS: The Turkish version of the Nurse Bladder Survey was used to estimate the prevalence of LUTS and to assess the relationship between individual characteristics, personal habits and work-related factors in nurses and secretaries who were working in Eskisehir Osmangazi University Hospital. The Turkish version of the Short Form 36 Health Survey was used to assess the nurses' and secretaries' health-related quality of life (HRQL). RESULTS: Of the 281 women who participated in the study, 218 (77.5%) and 63 (22.5%) were nurses and secretaries, respectively. There were no significant differences in personal habits and work-related factors between the nurses and secretaries. Of the study participants, 121 (43.1%) experienced at least one type of LUTS. There were no significant differences in the prevalence of any type of LUTS between the two groups. Only the mean scores of social functioning were significantly different for nurses and secretaries on the other aspects of HRQL in the SF-36. When the nurses with LUTS and the secretaries with LUTS were compared, the secretaries had a greater score on the general health domain than nurses. CONCLUSION: There is a vicious circle between symptoms and work conditions. To prevent the working women from harmful effects of this circle, the employers should be aware of this health problem; working conditions should be improved; educational programs for LUTS should be organized and the working women should be encouraged to go to the health providers to seek treatment when the symptoms occurred.


Assuntos
Sintomas do Trato Urinário Inferior/epidemiologia , Enfermagem , Doenças Profissionais/epidemiologia , Ocupações , Adulto , Estudos Transversais , Feminino , Humanos , Prevalência
14.
Urol Int ; 96(2): 212-6, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-26731689

RESUMO

INTRODUCTION: Our aim was to predict the chemical composition of kidney stones according to their twinkle artefact (TA) features obtained by in vivo color Doppler ultrasonography and to determine the potential factors affecting the formation and intensity of TAs. MATERIALS AND METHODS: A total of 101 patients who met the inclusion criteria were included in the study. All patients were evaluated for TAs using color Doppler ultrasonography. All stones were subjected to chemical analysis. The relationships between the TA and the size and chemical composition of the stone, presence of hydronephrosis and body mass index (BMI) were evaluated statistically. RESULTS: According to the results of the chemical analysis, 66 (65.3%) were calcium oxalate stones. It was found that the in vivo TA intensity did not predict cystine and calcium oxalate monohydrate stones (p > 0.05) and the intensity of TAs increases with increasing BMI (p = 0.002). CONCLUSION: The present study is the first to show that TAs may not be reliable in overweight patients. The TAs could not predict the chemical composition of stones; so future comprehensive in vivo studies will clarify the role of TAs in the prediction of the stone type preoperatively.


Assuntos
Artefatos , Oxalato de Cálcio/análise , Cálculos Renais/química , Cálculos Renais/diagnóstico por imagem , Ultrassonografia Doppler em Cores , Adulto , Índice de Massa Corporal , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Estudos Prospectivos , Reprodutibilidade dos Testes
15.
Eur Arch Otorhinolaryngol ; 273(1): 133-7, 2016 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-25876002

RESUMO

To assess sexual functioning in male and female partners before and after nasal continuous positive airway pressure (CPAP) therapy in men with obstructive sleep apnea (OSA). Twenty-one male patients with moderate to severe OSA and erectile dysfunction, and their female partner, were recruited into this prospective study. Males diagnosed with OSA were treated with nasal CPAP therapy for 12 weeks. Women were assessed for sexual functioning using the Female Sexual Function Index (FSFI), and for mood status using the Beck Depression Inventory (BDI), before and after their male partner underwent nasal CPAP therapy. Sexual functioning was assessed in men using the International Index of Erectile Function (IIEF), before and after nasal CPAP therapy. After nasal CPAP therapy for OSA in men, IIEF scores were significantly higher than pre-treatment scores. Total pre- and post-treatment IIEF scores (mean ± standard deviation) were 50.28 ± 15.88 and 65.42 ± 7.47, respectively, P < 0.01. Pre- and post-treatment FSFI scores in women were 21.54 ± 6.62 and 29.94 ± 3.76, respectively, P < 0.01. Pre- and post-treatment BDI scores in women were 14.61 ± 9.69 and 12.42 ± 8.92, respectively, P < 0.01. Following treatment of men with OSA, our data indicate benefits for nasal CPAP therapy on sexual functioning in both the male and female partners. Moreover, our findings indicate that improved sexual function in women after their male partner underwent nasal CPAP also had psychological benefits.


Assuntos
Pressão Positiva Contínua nas Vias Aéreas , Comportamento Sexual , Apneia Obstrutiva do Sono/terapia , Adulto , Disfunção Erétil/complicações , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Apneia Obstrutiva do Sono/complicações
16.
Ren Fail ; 37(7): 1122-5, 2015 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-26067744

RESUMO

Although colchicines are the only effective treatment of familial Mediterranean fever (FMF), resistance to colchicines (CR) which is observed in up to 30% of the patients is still a problem. Clinically, resistance to colchicine is defined as three or more attacks within the last 6 months period while using ≥2 mg/day colchicine. Previous studies have shown decreased vitamin D levels in FMF patients compared with healthy controls. The aim of this study is to evaluate whether vitamin D levels differ between CR and non-CR FMF patients. This study included 64 FMF patients who were being followed in Nephrology Clinic of Samsun Research and Education Hospital for at least 1 year. FMF was diagnosed according to the criteria defined by Livneh et al. Serum 25-hydroxy vitamin D (25-OHD) concentration (ng/mL) was detected in all FMF patients who were not in an acute attack period. From 64 patients 29 were accepted as CR. Mean 25-OHD level was 9.39 ± 1.00 ng/mL in CR patients and 18.48 ± 1.09 ng/mL in colchicine responsive patients (p < 0.001). Plasma vitamin D levels were significantly lower in colchicine resistant patients. Vitamin D deficiency may be a factor in etiopathogenesis of CR. Studies in larger patient samples that particularly evaluate the response to vitamin D replacement in CR FMF patients are needed.


Assuntos
Colchicina/administração & dosagem , Proteínas do Citoesqueleto/genética , Febre Familiar do Mediterrâneo/sangue , Febre Familiar do Mediterrâneo/tratamento farmacológico , Febre Familiar do Mediterrâneo/genética , Vitamina D/análogos & derivados , Adulto , Estudos de Casos e Controles , Feminino , Humanos , Masculino , Mutação , Pirina , Resultado do Tratamento , Vitamina D/sangue
17.
Ren Fail ; 37(4): 567-71, 2015 May.
Artigo em Inglês | MEDLINE | ID: mdl-25694191

RESUMO

Although guidelines recommend catheters as a last resort for establishing a vascular access in patients undergoing dialysis, they continue to be used widely for this purpose. Catheter-related atrial thrombus (CRAT) is rarely reported in this group of patients, and it can lead to serious complications. The aim of this study was to determine the incidence of CRAT in patients undergoing hemodialysis with permanent-tunneled catheters. A total of 50 patients undergoing hemodialysis with permanent catheters were included in this study. The diagnosis of CRAT was based on transthoracic echocardiography findings. Thrombus was present in nine patients (18%) and related to the tip of the catheter in all cases. Except for one patient with two foci of thrombus, all patients had a single focus. There were no significant associations between the development of thrombus and the duration of catheter use or the location of the catheter. Furthermore, catheter-related atrial thrombus did not appear to have a significant effect on mortality. The asymptomatic character of CRAT can be responsible for the low reporting rates, and its exact role in increased mortality and morbidity related with catheter use remains unknown. While planning management strategies, information on different options for vascular access routes and possible catheter-related complications should be provided to all patients who will undergo dialysis, together with a discussion involving other replacement alternatives for end-stage renal disease.


Assuntos
Cateteres de Demora/efeitos adversos , Átrios do Coração , Cardiopatias/etiologia , Trombose/etiologia , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Diálise Renal/instrumentação
18.
Turk J Med Sci ; 44(4): 606-10, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-25551930

RESUMO

BACKGROUND/AIM: To investigate serum asymmetric dimethyl arginine (ADMA) levels in maintenance hemodialysis (HD) patients and to assess their potential correlations with C-reactive protein (CRP), albumin, and cholesterol levels as the established cardiovascular and nutritional parameters. MATERIALS AND METHODS: Forty-nine patients on maintenance HD treatment and 22 healthy volunteers with similar age and sex characteristics were recruited into the study. Serum albumin, CRP, creatinine, calcium, phosphate, total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, hemoglobin, white blood cell counts, and serum ADMA levels were measured. RESULTS: HD patients had significantly higher ADMA levels compared with healthy controls (0.51 ± 0.25 vs. 0.35 ± 0.15, P = 0.002). While white blood cell counts and body mass index values were similar between the 2 groups, CRP and LDL cholesterol were significantly higher and albumin and HDL cholesterol were significantly lower in HD patients compared with healthy controls. ADMA concentrations were positively correlated with mean age (P = 0.02, r = 0.360), LDL cholesterol levels (P = 0.006, r = 0.325), and CRP levels (P = 0.02, r = 0.268) and negatively correlated with serum albumin levels (P = 0.005, r = -0.331). CONCLUSION: ADMA levels were found to be higher in HD patients and were shown to be correlated with preestablished inflammatory and nutritional biomarkers.


Assuntos
Arginina/análogos & derivados , Falência Renal Crônica/sangue , Falência Renal Crônica/terapia , Diálise Renal , Adulto , Idoso , Arginina/sangue , Biomarcadores/sangue , Proteína C-Reativa/metabolismo , Estudos de Casos e Controles , Colesterol/sangue , Estudos Transversais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Albumina Sérica/metabolismo
19.
Clin Appl Thromb Hemost ; 20(3): 334-7, 2014 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-23076775

RESUMO

We aimed to determine whether red cell distribution width (RDW) and mean platelet volume (MPV) values differ between patients with reactive amyloid A (AA) amyloidosis due to chronic inflammatory disease and in healthy participants. In this study, 33 patients with AA amyloidosis and 40 age- and sex-matched healthy controls were enrolled. Erythrocyte sedimentation rate (ESR), RDW, platelet count (PLT), and MPV levels were retrospectively obtained from our computerized patient database. We found RDW, ESR, and PLT levels to be significantly higher in patients with AA amyloidosis compared with the controls (P < .0001). Mean platelet volume was significantly lower in patients with amyloidosis (P < .0001). Inflammatory diseases such as AA amyloidosis may demonstrate low MPV and high RDW levels.


Assuntos
Amiloidose/sangue , Adulto , Índices de Eritrócitos , Feminino , Humanos , Masculino , Volume Plaquetário Médio/métodos
20.
Blood Press ; 23(1): 47-53, 2014 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-23721572

RESUMO

PURPOSE: Arterial hypertension is a risk factor affecting graft function in renal transplant recipients (RTRs). In pediatric RTRs, high prevalence of masked and nocturnal hypertension was reported. Most of the RTRs had a history of hypertension and some of them were normotensive at outpatient visits whereas home blood pressure (BP) levels were higher. Masked hypertension (MHT) is defined as a normal office BP but an elevated ambulatory BP. Previous reports have demonstrated the detrimental role of MHT in clinical outcomes in hypertensive patients. However, the true prevalence of MHT in RTRs is yet to be defined. METHODS: A total of 113 RTRs (mean age 44 ± 16 years, 72 males, 41 females) with normal office BP (< 140/90 mmHg) were enrolled to the study from the outpatient renal transplantation clinic. Ambulatory BP monitoring (ABPM) was performed in all participants for a 24-h period. Average daytime BP values above 135 mmHg systolic and 85 mmHg diastolic were defined as MHT. RESULTS: The prevalence of MHT in our cohort was 39% (n = 45). Fasting glucose and C-reactive protein levels were higher in patients with MHT compared with normal BP group (p = 0.02 and p = 0.04, respectively). RTRs with deceased donor type had higher prevalence of MHT than RTRs with living donor (40% vs 19%, p = 0.003). In multivariate analysis, deceased donor type could predict the MHT independent of age, gender, office systolic BP level, diabetes mellitus, serum creatinine, C-reactive protein, and glucose levels (OR = 3.62, 95% CI 1.16-11.31, p = 0.03). CONCLUSION: We demonstrated an increased prevalence of MHT in a typical renal transplant cohort. In addition, transplantation from a deceased donor may be a predictor of MHT. The prevalence of MHT may help to explain high rate of cardiovascular events in RTRs. Therefore, routine application of ABPM in RTRs may be plausible, particularly in RTRs with deceased donor type.


Assuntos
Transplante de Rim/efeitos adversos , Hipertensão Mascarada/etiologia , Adulto , Monitorização Ambulatorial da Pressão Arterial , Estudos de Coortes , Feminino , Humanos , Masculino , Hipertensão Mascarada/diagnóstico , Prevalência , Fatores de Risco
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