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1.
Phytother Res ; 33(8): 2002-2014, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31373113

RESUMO

The aim of this review is to obtain a further understanding of the reported inhibitory effects of polyphenols on cancer cell proliferation and angiogenesis process and the probable mechanisms by which these natural compounds inhibit proliferation of cancer cells and angiogenesis. Growing evidence indicates that polyphenols are beneficial against human fatal diseases such as cancer. Because angiogenesis has a critical role in tumor growth and metastasis, therefore, we decided to review the potential anticancer and antiangiogenic activities and molecular mechanisms of different groups of known polyphenolic compounds. As knowledge and data on anticancer and antiangiogenic effects of plant-derived phenols are on the rise, it may be possible in the near future to develop and discover specific polyphenolic compounds with potent anticancer and antiangiogenic activity for treatment of malignant tumors.


Assuntos
Inibidores da Angiogênese/uso terapêutico , Neoplasias/tratamento farmacológico , Polifenóis/uso terapêutico , Inibidores da Angiogênese/farmacologia , Apoptose , Humanos , Polifenóis/farmacologia
2.
Mol Biol Rep ; 46(5): 5041-5048, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31273613

RESUMO

Thalassemia is one of the most common monogenic hereditary disorders. Despite noticeable advances made in prevention strategies, it is still highly prevalent in the Iranian population. A key approach to management and early diagnosis of the disease is through revealing the regions with high prevalence and determining common genetic and phenotypic diversity. In the current study Hemoglobin H (HbH) disease patients were analyzed as the most common form of thalassemia intermedia in Iran. A total of 80 patients suspected of being thalassemic according to their mild to moderate anemia, microcytosis and normal iron levels were included in this study at the hemoglobinopathy and thalassemia center of Ahvaz University of Medical Science. Patients were analyzed for hematological parameters and HbH mutations using Multiplex Gap Polymerase Chain Reaction and Multiplex Amplification Refractory Mutation System. Twelve mutations were detected in the studied population. The most common genotype was -α3.7/--MED (45%) followed by Homozygote αPoly A2 (17.5%). A total of ten different alpha-globin (α-globin) mutations were observed in patients which --MED, being the most common mutation (26.27%), followed by -α3.7 (24.37%) and αpolyA2(A>G) (18.12%). Hematological parameters such as Hb, MCV, MCH and HbH were assessed and results showed that they varied significantly among genotypes, adjusted to age and gender. This study reveals a highly diverse range of HbH patients different from what was thought in terms of both genotype and phenotype in the Khuzestan region of Iran. These findings could contribute to improve the thalassemia managing policies in this province.

3.
Blood Cells Mol Dis ; 74: 1-4, 2019 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-30293687

RESUMO

OBJECTIVE: Portal vein thrombosis (PVT) has been described as a rare complication after splenectomy. PVT associated risk factors after splenectomy in hematological disorders are poorly recognized. The aim of this study was to assess the prevalence and risk factors of PVT incidence in splenectomized patients. METHODS: One hundred twelve splenectomized patients with various hematologic diseases between 2008 and 2018 were enrolled in this study. Diagnosis was confirmed by Doppler ultrasonography (DUSG) and risk factors for PVT were sought based on the comparison of clinical and laboratory features between patients without and with PVT. RESULT: PVT was diagnosed in 4 (3.57%) patients in spite of receiving antiplatelet therapy. Patients with PVT were ß-thalassemia major (n = 2) and ß-thalassemia intermedia (n = 2). ß-thalassemia patients had a 3.5 times higher odds for PVT (95% CI: 2.41-5.33). No significant differences between patients with and without PVT in terms of age, gender and laboratory features were found. CONCLUSION: According to our data, ß-thalassemia, especially intermediate form, may be a risk factor for PVT and it can occur in spite of receiving antiplatelet therapy. Given that ß-thalassemia patients are at risk, early PVT detection may be useful for reduction of fatal PVT complication in splenectomized patients.


Assuntos
Doenças Hematológicas/complicações , Veia Porta/patologia , Esplenectomia/efeitos adversos , Trombose Venosa/etiologia , Estudos de Casos e Controles , Humanos , Incidência , Estudos Retrospectivos , Fatores de Risco , Trombose Venosa/diagnóstico , Talassemia beta/complicações
4.
Biochem Genet ; 56(5): 506-521, 2018 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-29627922

RESUMO

Alpha thalassemia is the most prevalent monogenic gene disorder in the world, especially in Mediterranean countries. In the current hematological phenotype of patients with different genotypes, the effects of missense mutations on the protein function and also stability were evaluated in a large cohort study. A total of 1,560 subjects were enrolled in the study and divided into two groups: 259 normal subjects; and 1301 alpha-thalassemia carriers. Genomic DNA was extracted and analyzed using ARMS PCR, Multiplex Gap, and direct sequencing. The effects of single nucleotide change on the protein function and stability were predicted by freely available databases of human polymorphisms. Sixty-three different genotypes were seen in the patients. The more prevalent was heterozygote form of -α3.7 (41.4%) followed by -α3.7 homozygote (11.6%) and -MED (3.8%). The significant differences were seen in mean hemoglobin level [F = 20.5, p < 0.001] between the Alpha-globin genotypes, when adjusted for gender. Moreover, 28 different mutations were found in our study. A significant relationship was seen between ethnicity and the alpha-globin mutation frequency χ2 (df;8) = 38.36, p < 0.0001). Different genotypes could display as different phenotypes. The mutation frequency distributions in our region are different from those of other parts of Iran. Significant differences are seen in the spectrum of mutation frequency among various ethnicities. Finally, some missense mutations might not have considerable effect on the proteins, and they could be neutral mutations.


Assuntos
Grupo com Ancestrais do Continente Europeu/genética , Mutação de Sentido Incorreto , alfa-Globinas/genética , Talassemia alfa/genética , Adulto , Estudos de Coortes , Grupo com Ancestrais do Continente Europeu/etnologia , Feminino , Humanos , Irã (Geográfico)/etnologia , Masculino , Estabilidade Proteica , Análise de Sequência de DNA , Adulto Jovem , alfa-Globinas/química , alfa-Globinas/metabolismo
5.
J Epidemiol Glob Health ; 8(3-4): 189-195, 2018 12.
Artigo em Inglês | MEDLINE | ID: mdl-30864762

RESUMO

This prospective study assessed the prevalence and genetic analysis of α- and ß-thalassemia and sickle cell anemia (SCA) in Southwest Iran. Hematological indices were measured in 17,581 couples living in Khuzestan Province, Southwest Iran. Individuals with mean corpuscular volume <80, mean corpuscular hemoglobin <27, hemoglobin A2 ≥3/5 were considered as ß-thalassemia traits. Prevalence of minor ß-thalassemia, α-thalassemia, SCA, iron deficiency anemia, and silent thalassemia were respectively identified in 995 (5.6%), 1169 (6.65%), 1240 (7.05%), 911 (5.18%), and 1134 (6.45%) individuals using a multiplex amplification refractory mutation system, and direct DNA sequencing of globin genes. Three codons IVS-II-1 (G → A; 26%; n = 13), IVS-I-1 (G → T; 16%; n = 8), and IVS-I-110 (G → A; 14%; n = 7) were the most frequent mutants and IVS-II-1 was the most common ß-thalassemia mutation. Also, based on a gap-polymerase chain reaction assay, genotype frequencies of α-globin mutations were -α3.7 kb (50%; n = 25), Med/ααthal (12%; n = 6), and -α4.2/αα (10%; n = 5), which were the most frequent deletion mutants (72% in total). The most common deletion (50%) was -α3.7 kb. Our data suggest that the population of Southwest Iran is at high risk of α- and ß-thalassemia caused by these deletion mutants and SCA. Our findings will be useful for developing an efficient control program and genetic counseling.


Assuntos
Anemia Falciforme , Testes Genéticos , Prevalência , alfa-Globinas/genética , Talassemia alfa , Adulto , Anemia Falciforme/diagnóstico , Anemia Falciforme/epidemiologia , Anemia Falciforme/genética , Índices de Eritrócitos , Feminino , Testes Genéticos/métodos , Testes Genéticos/estatística & dados numéricos , Humanos , Irã (Geográfico)/epidemiologia , Masculino , Estudos Prospectivos , Deleção de Sequência , Talassemia alfa/diagnóstico , Talassemia alfa/epidemiologia , Talassemia alfa/etnologia , Talassemia alfa/genética , Talassemia beta/diagnóstico , Talassemia beta/epidemiologia , Talassemia beta/etnologia , Talassemia beta/genética
6.
Jundishapur J Microbiol ; 9(11): e41446, 2016 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-28138378

RESUMO

BACKGROUND: Neutropenia, as a predisposing factor for invasive candidiasis, is defined as a reduction in neutrophil count to less than 1500/mm3. It is a common condition in patients with hematological malignancy and cytostatic chemotherapy. Extensive chemotherapy and prophylaxis with antifungals have increased the resistance of Candida isolates to antifungal drugs. Although, Candida albicans is the most common causative agent among neutropenic patients, there is an increasing rate of non-albicans species. Extracellular enzymes activity pattern and antifungal agent sensitivity profiles are two important factors for spreading resistant strains. OBJECTIVES: The aim of the present study was to identify the Candida strains isolated from hospitalized neutropenic patients. The patterns of antifungal susceptibility of the causative agents to antifungals and the extracellular enzymes activity of the isolates were also evaluated. PATIENTS AND METHODS: In the present study, 243 urine and 243 oral swab samples were collected from neutropenic patients and inoculated on CHROMagar Candida. In addition, 100 blood samples were also inoculated in biphasic Brain Heart Infusion medium. Several yeast isolates were isolated from samples and identified by classical and molecular techniques. The profiles of extracellular enzymes and the susceptibility of recovered agents to amphotericin B, fluconazole and caspofungin were also evaluated. RESULTS: A total of 110 yeast strains isolated from urine and oral cavities were identified as C. albicans (51.8%), C. krusei (25.5%), C. glabrata (6.4%) and other yeasts (16.3%). No yeast species was isolated from blood samples. Our result showed that in 90% of the isolates, the range of secretion of extracellular enzymes was medium (2+) and high (3+), however only a few isolates were negative for this characteristic. All isolates were sensitive to caspofungin and fluconazole, whereas 54.7% of isolates were resistant to amphotericin B. CONCLUSIONS: We found a marked increase in the incidence of non-albicans species (48.2%) among neutropenic patients. Only a few strains failed to produce extracellular enzymes. Finally, in addition to fluconazole, caspofungin can be considered as the first line treatment against Candida species among neutropenic patients.

7.
J Clin Diagn Res ; 9(10): OM01-3, 2015 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-26557561

RESUMO

INTRODUCTION: It is well known that hydroxyurea (HU) impacts on clinical and haematologic indices in thalassemia. We aimed to evaluate the effect of hydroxyurea on clinical and haematological improvement in children with thalassemia intermedia. MATERIALS AND METHODS: After the patients' enrollment in the study their data such as transfusion, hospitalization, spleen size, visit, total Hb, HbF levels, MCV and MCH were compared before and after treatment with HU 10 mg/kg/day/for one year. RESULTS: In patients with thalassemia intermedia, HU significantly diminished the rate of transfusion, hospitalization, spleen size and significantly increased Hb MCH, HbF and MCV. Moreover HU was well tolerated in our patients and we got no remarkable adverse effect. CONCLUSION: We divulged hydroxyurea 10 mg/kg/day during one year. This significantly increased HbF, total haemoglobin, MCV, MCH, without any remarkable adverse events.

8.
Glob J Health Sci ; 8(3): 252-6, 2015 Aug 19.
Artigo em Inglês | MEDLINE | ID: mdl-26493428

RESUMO

BACKGROUND & AIM: it is well known that hydroxyurea impacts on clinical and hematologic indices in sickle cell disease (SCD), we aimed to evaluate the effect of hydroxyurea on clinical and hematological improvement of sickle cell anemia. METHODS & MATERIALS: In this cohort study 48 patients with sickle cell disease were enrolled and pain crisis, severity of pain, acute chest syndrome, the number of hospitalization, the rate of transfusion, spleen size, total Hb, HbF levels, MCV, MCH were compared before and after treatment with HU 10 mg/kg/day/for one year. RESULTS: In patients with Sickle cell disease Hu significantly decreased the rate of transfusion, hospitalization, spleen size and significantly increased Hb, RBC indices and HbF. Furthermore, we did not find any remarkable adverse effect related to HU during the one year follow up in patients. CONCLUSION: We demonstrated that in the course of one year hydroxyurea 10 mg/kg/day can significantly increase HbF, total hemoglobin and RBC indices without any notable side effect in patients with SCD.


Assuntos
Anemia Falciforme/tratamento farmacológico , Antidrepanocíticos/uso terapêutico , Hidroxiureia/uso terapêutico , Adolescente , Transfusão de Sangue/estatística & dados numéricos , Criança , Feminino , Hospitalização/estatística & dados numéricos , Humanos , Masculino , Medição da Dor , Baço/patologia , Resultado do Tratamento
9.
J Stroke ; 16(2): 97-101, 2014 May.
Artigo em Inglês | MEDLINE | ID: mdl-24949316

RESUMO

BACKGROUND AND PURPOSE: Sickle cell disease (SCD) is strongly linked to stroke across all haplotypes in the pediatric population. Transcranial Doppler (TCD) ultrasound is known to identify the highest risk group in African-Americans who need to receive and stay on blood transfusions, but it is unclear if the same flow velocity cut-offs can be applied to the Iranian population. We aimed to evaluate baseline TCD findings in Iranian children with SCD and no prior strokes. METHODS: Children with genetically confirmed SCD (Arabian haplotype, homozygote) and without SCD (controls) were prospectively recruited from pediatric outpatient clinic over a period of 9 months. We performed TCD in both groups to determine flow velocities in the middle cerebral (MCA) and terminal internal carotid arteries (TICA). RESULTS: Of 74 screened children, 60 met the inclusion/exclusion criteria (62% female; mean age 10±4 years). Baseline characteristics did not differ between the cases and controls, except hemoglobin (Hb) which was significantly lower in the SCD group (P<0.001). The right MCA TAMM (Time Averaged Maximum Mean) was significantly higher than in controls (125+5.52 cm/s vs. 92.5+1.63 cm/s, P<0.001). Left MCA did not show differences. The TICA TAMM was also different between cases and controls (P<0.05). CONCLUSIONS: Among Iranian children with asymptomatic SCD and without receiving recent transfusion TCD velocities are higher as compared to healthy controls but appear much lower than those observed in STOP (Stroke Prevention Trial in Sickle Cell Anemia) studies. We hypothesize that some children at high risk may be present with velocities lower than 170-200 cm/s thresholds. A prospective validation of ethnicity-specific prognostic criteria is warranted.

10.
Eur J Pediatr ; 173(12): 1663-5, 2014 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-24357267

RESUMO

UNLABELLED: Thiamine-responsive megaloblastic anemia (TRMA) or Roger syndrome is a rare autosomal recessive disorder characterized by the occurrence of multiple clinical manifestations including megaloblastic anemia, diabetes mellitus, and sensorineural deafness. A few patients have been also described with congenital cardiac malformations. The patients usually respond to treatment with pharmacological doses of thiamine. Mutations in the SLC19A2 gene, located at chromosome 1q24.2, are responsible for this syndrome. Here, we present two new Iranian TRMA patients who were homozygous for c.697C > T mutation in the SLC19A2 gene. On follow-up, one of the patients showed Ebstein anomaly. CONCLUSION: The present study confirms the variability of the clinical manifestations caused by the same mutation within patients with TRMA syndrome. Therefore, follow-up of the affected children should be considered.


Assuntos
Anormalidades Múltiplas , Anemia Megaloblástica/genética , DNA/genética , Diabetes Mellitus/genética , Anomalia de Ebstein/genética , Perda Auditiva Neurossensorial/genética , Complexo Cetoglutarato Desidrogenase/deficiência , Proteínas de Membrana Transportadoras/genética , Mutação , Adolescente , Anemia Megaloblástica/diagnóstico , Anemia Megaloblástica/metabolismo , Pré-Escolar , Análise Mutacional de DNA , Diabetes Mellitus/diagnóstico , Diabetes Mellitus/metabolismo , Diagnóstico Diferencial , Anomalia de Ebstein/diagnóstico , Anomalia de Ebstein/metabolismo , Ecocardiografia , Perda Auditiva Neurossensorial/diagnóstico , Perda Auditiva Neurossensorial/metabolismo , Homozigoto , Humanos , Complexo Cetoglutarato Desidrogenase/genética , Complexo Cetoglutarato Desidrogenase/metabolismo , Masculino , Proteínas de Membrana Transportadoras/metabolismo , Deficiência de Tiamina/congênito
11.
Eur Cytokine Netw ; 24(1): 45-52, 2013 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-23608554

RESUMO

OBJECTIVE: This study aimed to evaluate serum levels of pro-inflammatory cytokines and TGF-ß in sickle cell disease (SCD) patients, and to compare the results during vaso-occlusive crisis (VOC) or steady state (StSt) conditions. METHODS: 54 SCD patients (37HbSS and 17Sß(+)Thal) were enrolled in the study and evaluated in two groups as follows; group A consisted of 39 VOC patients and group B comprised 15 StSt patients. Nineteen healthy volunteers were included as controls. Circulating levels of IL-1, IL-6, IL-8, IL-17,TNF-α and TGF-ß were measured using ELISA. RESULTS: Patients in VOC showed higher mean levels of all cytokines than those found in steady-state patients, but this was only marginally significant for IL-8 levels (P = 0.08). Increased levels of TGF-ß and IL-17 were found in StSt patients versus normal controls (P = 0.004 and P<0.0001 respectively). A positive correlation was observed between IL-8 and IL-17 in both groups of patients (P = 0.002 and P = 0.005 respectively). Decreased levels of TNF-α, IL-1ß and IL-17 were found in hydroxyurea-treated patients. Additionally, significantly higher levels of IL-6 and IL-8 were observed in hydroxyurea-treated and untreated patients than in controls respectively (P = 0.04 and P = 0.01). CONCLUSIONS: Our findings indicate that pro-inflammatory cytokines, especially IL-8 and IL-17, could be used as related markers for assessing disease severity, and consequently therapeutic intervention.


Assuntos
Anemia Falciforme/sangue , Citocinas/sangue , Mediadores da Inflamação/sangue , Doenças Vasculares/sangue , Anemia Falciforme/tratamento farmacológico , Estudos de Casos e Controles , Demografia , Feminino , Humanos , Hidroxiureia/farmacologia , Hidroxiureia/uso terapêutico , Masculino , Doenças Vasculares/tratamento farmacológico , Adulto Jovem , Talassemia beta/sangue , Talassemia beta/tratamento farmacológico
12.
Hematol Rep ; 4(2): e7, 2012 May 10.
Artigo em Inglês | MEDLINE | ID: mdl-22826797

RESUMO

The presence of apparently normal hematopoietic tissue outside of bone marrow cavity is defined as extramedullary hematopoiesis (EMH). EMH is a rare complication in thalassemia major (TM) and adrenal gland as well. This report describes a case of adrenal EMH in a 26-year-old man with ß-TM. He has been transfused with regular blood transfusion since 9 months. During the routine physical examination he was incidentally found to have a hypoechoic mass at his abdominal ultrasonography. Abdominal computed tomography scan revealed a right well-defined suprarenal mass 7.7×7.3×5.8 cm in size. The diagnosis of EMH was confirmed with ultrasonographic-guided fine needle biopsy. Treatment options which include intensified regular blood transfusion and hydroxyurea have been started.

13.
J Tehran Heart Cent ; 7(3): 106-10, 2012 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-23304178

RESUMO

BACKGROUND: Sickle-cell disease (SCD) is an inherited hemoglobin childhood disorder, frequently complicated by pulmonary hypertension and cardiac involvement. Cardiovascular events and complications are the leading cause of mortality and morbidity in patients with SCD. Tissue Doppler imaging and the myocardial performance index (Tei index), are simple indices for the assessment of the cardiac function. The purpose of this study was to assess the left ventricular function in children with SCD. METHODS: Sixty-four patients with SCD (mean age = 11.7 ± 5.5 years) were compared with 50 age-matched healthy controls (mean age = 11.2 ± 5.20 years). Myocardial wall motion velocities at the lateral mitral annulus and the junction between the medial mitral annulus and the interventricular septum were assessed during systole (Sa), early diastole (Ea), and late diastole (Aa) through a four-chamber view using pulsed Doppler echocardiography. The ejection fraction and shortening fraction were estimated. The Tei index was estimated via tissue Doppler echocardiography. RESULTS: The results showed that Ea and Aa velocity in the mitral annulus and interventricular septum had no difference between the patients and controls (p value > 0.05), and nor was there any difference between the two groups as regards the Tei index, Ea/Aa, ejection fraction, and shortening fraction (p value > 0.05). Sa(m) wave velocity, however, had a significant difference between the two groups (p value < 0.038). CONCLUSION: The Tei index is a sensitive indicator for the cardiac function in chronic diseases and the right ventricular function in some disorders such as SCD.

14.
J Med Case Rep ; 5: 274, 2011 Jul 02.
Artigo em Inglês | MEDLINE | ID: mdl-21722393

RESUMO

INTRODUCTION: Iliopsoas hemorrhage is a serious complication of bleeding disorders that occurs most commonly in patients with hemophilia and less commonly in patients with von Willebrand disease. It causes severe pain, muscle dysfunction and occasionally femoral nerve palsy. We describe the case of a patient with von Willebrand disease type 3 with a large iliopsoas hematoma who was treated with a von Willebrand factor concentrate (Humate-P). CASE PRESENTATION: A 20-year-old Iranian man was referred to our emergency ward because of the gradual onset of right flank pain. He was known to have been diagnosed with von Willebrand disease type 3 at age two years old. Magnetic resonance imaging showed a mass in the right iliopsoas muscle. The diagnosis of iliopsoas hemorrhage and partial femoral nerve palsy was established, and he responded to medical treatment. CONCLUSION: We report a case of von Willebrand disease type 3 with spontaneous iliopsoas hematoma associated with femoral nerve palsy that was well managed with Humate-P treatment.

15.
Hemoglobin ; 34(5): 461-8, 2010.
Artigo em Inglês | MEDLINE | ID: mdl-20854120

RESUMO

ß-Thalassemia (ß-thal) is characterized by reduction or absence of ß-globin gene expression. We describe the spectrum of mutations observed in a large cohort of ß-thal carriers in Khuzestan, Southwest Iran. All together 1,241 blood samples from individuals with decreased mean corpuscular volume (MCV) and elevated Hb A(2) levels, were analyzed either by reverse dot-blot or by direct sequencing of the HBB gene. We found 42 different mutations associated with ß-thal and identified eight common ß-globin variants, namely, Hb S [ß6(A3)Glu→Val], Hb C [ß6(A3)Glu→Lys], Hb D-Punjab [ß121(GH4)Glu→Gln] and Hb O-Arab [ß121(GH4)Glu→Lys]. No mutations were found in two individuals. The distribution is characteristic of a heterogenous population with three preferential mutations being present [codons 36/37 (-T), IVS-II-1 (G>A) and IVS-I-110 (G>A)] at a frequency of 20.5, 20.0 and 14.2%, respectively, followed by 39 mutations in decreasing frequencies from 5.2 down to 0.1%. These data are of importance when planning prevention strategies in the country.


Assuntos
Mutação , Globinas beta/genética , Talassemia beta/genética , Análise Mutacional de DNA , Primers do DNA , Frequência do Gene , Genótipo , Geografia , Hemoglobina Falciforme/genética , Hemoglobinas Anormais/genética , Humanos , Irã (Geográfico) , Reação em Cadeia da Polimerase/métodos
16.
Turk J Haematol ; 26(3): 138-45, 2009 Sep 05.
Artigo em Inglês | MEDLINE | ID: mdl-27265497

RESUMO

OBJECTIVE: Iron deficiency anemia (IDA) and ß- Thalassemia Trait (ß-TT) are the most common forms of microcytic anemia. This study was conducted to compare the validity of these discrimination indices in differentiating ß- Thalassemia Trait (ß-TT) from IDA by calculating their sensitivity, specificity and Youden's index. METHODS: Totally 323 subjects (173 children and 150 adult) with microcytic anemia were involved in this study. We calculated 10 discrimination indices in all patients with IDA and ß-TT. We divided the patients into two different groups as younger and older than 10 years. RESULTS: None of indices showed sensitivity and specificity of 100% in the patients older than 11 years, but only Shine and Lal Index showed sensitivity close to 90% and specificity of 100% in the patients younger than 10 years. The most accurate discriminative index for patients younger than 10 years was Shine & Lal and in case of patients older than 11 years it was RDWI. Youden's index for Shine & Lal & RBC Count and for RDWI & RBC Count indices has most diagnostic value for younger and older than 10 years, respectively. CONCLUSION: None of the indices was completely sensitive and specific in differentiation between ß-TT and IDA. MCHD mean and median were very close to normal values for both IDA and ß-TT patients, but in case of MHDL we have found mean and median were significantly higher than normal values in ß-TT and lower than those in IDA patients. In our study, Youden's index of RBC and S & L were the highest and the most reliable discrimination indices in differentiating ß-TT from IDA in the patients younger than 10 years and for patients older than 11 years, the most reliable discrimination indices were RBC and RDWI.

17.
Hematology ; 13(3): 183-6, 2008 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-18702878

RESUMO

Extramedullary hematopoiesis (EMH) is a rare disorder, characterized by the appearance of hematopoietic elements outside of the bone marrow, which occurs in patients with chronic myeloproliferative disorders or congenital hemolytic anemias. We report a case with thalassemia intermedia, EMH in spinal cord and a paravertebral mass. We report the case of a 20 year old female who initially presented with back pain and leg weakness was found to have paravertebral mass in the spinal cord.


Assuntos
Hematopoese Extramedular/fisiologia , Compressão da Medula Espinal/etiologia , Talassemia beta/complicações , Talassemia beta/fisiopatologia , Adulto , Dor nas Costas/etiologia , Feminino , Humanos , Perna (Membro) , Debilidade Muscular/etiologia , Neoplasias da Medula Espinal/complicações
18.
Food Nutr Bull ; 28(4): 406-11, 2007 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-18274167

RESUMO

BACKGROUND: Iron deficiency is a major health problem worldwide and especially in developing countries. Iron-deficiency anemia has adverse effects on the development of children. OBJECTIVE: The purpose of this study was to determine the prevalence of iron-deficiency anemia in children under 5 years of age in southwest Iran. The study also sought to investigate the association between socioeconomic, demographic, cultural, and nutritional factors and iron-deficiency anemia in the selected area. METHODS: A randomized, cross-sectional study was performed of children 6 to 59 months of age living in urban and rural areas of Ahwaz District in Khuzestan Province. At eight randomly selected health centers, the children's height (or length) and weight were measured, and information on length and weight at birth was obtained from growth charts. Blood samples were taken from 337 randomly selected children. RESULTS: The results showed that 43.9% of the children had anemia and 29.1% iron-deficiency anemia. The highest prevalence of iron-deficiency anemia was in the 12- to 24-month age group. In the urban areas, infants 6 to 11 months of age had the highest prevalence of iron-deficiency anemia. CONCLUSIONS: The high prevalence of iron-deficiency anemia among children in southwest Iran indicates a major nutrition and health problem.


Assuntos
Anemia Ferropriva/epidemiologia , Anemia/epidemiologia , Ferro/sangue , Ferro/deficiência , Estado Nutricional , Anemia/sangue , Anemia Ferropriva/sangue , Peso ao Nascer , Estatura/fisiologia , Peso Corporal/fisiologia , Fenômenos Fisiológicos da Nutrição Infantil , Pré-Escolar , Estudos Transversais , Feminino , Hemoglobinas/análise , Humanos , Lactente , Irã (Geográfico)/epidemiologia , Masculino , Inquéritos Nutricionais , Vigilância da População , Prevalência , População Rural , População Urbana
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