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2.
AJOB Neurosci ; 11(2): 105-112, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32228383

RESUMO

This article examines the ethical and policy implications of using voice computing and artificial intelligence to screen for mental health conditions in low income and minority populations. Mental health is unequally distributed among these groups, which is further exacerbated by increased barriers to psychiatric care. Advancements in voice computing and artificial intelligence promise increased screening and more sensitive diagnostic assessments. Machine learning algorithms have the capacity to identify vocal features that can screen those with depression. However, in order to screen for mental health pathology, computer algorithms must first be able to account for the fundamental differences in vocal characteristics between low income minorities and those who are not. While researchers have envisioned this technology as a beneficent tool, this technology could be repurposed to scale up discrimination or exploitation. Studies on the use of big data and predictive analytics demonstrate that low income minority populations already face significant discrimination. This article urges researchers developing AI tools for vulnerable populations to consider the full ethical, legal, and social impact of their work. Without a national, coherent framework of legal regulations and ethical guidelines to protect vulnerable populations, it will be difficult to limit AI applications to solely beneficial uses. Without such protections, vulnerable populations will rightfully be wary of participating in such studies which also will negatively impact the robustness of such tools. Thus, for research involving AI tools like voice computing, it is in the research community's interest to demand more guidance and regulatory oversight from the federal government.

3.
Sensors (Basel) ; 20(4)2020 Feb 13.
Artigo em Inglês | MEDLINE | ID: mdl-32069891

RESUMO

Olfaction can enhance the experience of music, films, computer games and virtual reality applications. However, this area is less explored than other areas such as computer graphics and audio. Most advanced olfactory displays are designed for a specific experiment, they are hard to modify and extend, expensive, and/or can deliver a very limited number of scents. Additionally, current-generation olfactory displays make no decisions on if and when a scent should be released. This paper proposes a low-cost, easy to build, powerful smart olfactory display, that can release up to 24 different aromas and allow control of the quantity of the released aroma. The display is capable of absorbing back the aroma, in an attempt to clean the air prior to releasing a new aroma. Additionally, the display includes a smart algorithm that will decide when to release certain aromas. The device controller application includes releasing scents based on a timer, text in English subtitles, or input from external software applications. This allows certain applications (such as games) to decide when to release a scent, making it ideal for gaming. The device also supports native connectivity with games developed using a game development asset, developed as part of this project. The project was evaluated by 15 subjects and it was proved to have high accuracy when the scents were released with 1.5 minutes' delay from each other.

5.
Heart Views ; 20(4): 172-174, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31803375

RESUMO

Aortic root enlargement (ARE) is an established procedure to deal with small aortic annulus. It becomes very important to place adequate size prosthesis to prevent patient-prosthesis mismatch (PPM). Aortic root enlargement procedures procedures are technically demanding operations, particularly in obese patients. The presence of coronary artery anomalies adds more complexity to the procedure. We present an interesting case of a 22-year-old obese female with symptomatic severe aortic valve stenosis and anomalous coronary arteries. We successfully performed aortic valve replacement using the combined Konno aortoventriculoplasty and Manouguian posterior aortic root enlargement. Combined aortic root enlargement techniques techniques should be considered in the presence of major coronary anomalies.

6.
ACS Nano ; 13(11): 12525-12539, 2019 11 26.
Artigo em Inglês | MEDLINE | ID: mdl-31621284

RESUMO

Myocardial microenvironment plays a decisive role in guiding the function and fate of cardiomyocytes, and engineering this extracellular niche holds great promise for cardiac tissue regeneration. Platforms utilizing hybrid hydrogels containing various types of conductive nanoparticles have been a critical tool for constructing engineered cardiac tissues with outstanding mechanical integrity and improved electrophysiological properties. However, there has been no attempt to directly compare the efficacy of these hybrid hydrogels and decipher the mechanisms behind how these platforms differentially regulate cardiomyocyte behavior. Here, we employed gelatin methacryloyl (GelMA) hydrogels containing three different types of carbon-based nanoparticles: carbon nanotubes (CNTs), graphene oxide (GO), and reduced GO (rGO), to investigate the influence of these hybrid scaffolds on the structural organization and functionality of cardiomyocytes. Using immunofluorescent staining for assessing cellular organization and proliferation, we showed that electrically conductive scaffolds (CNT- and rGO-GelMA compared to relatively nonconductive GO-GelMA) played a significant role in promoting desirable morphology of cardiomyocytes and elevated the expression of functional cardiac markers, while maintaining their viability. Electrophysiological analysis revealed that these engineered cardiac tissues showed distinct cardiomyocyte phenotypes and different levels of maturity based on the substrate (CNT-GelMA: ventricular-like, GO-GelMA: atrial-like, and rGO-GelMA: ventricular/atrial mixed phenotypes). Through analysis of gene-expression patterns, we uncovered that the engineered cardiac tissues matured on CNT-GelMA and native cardiac tissues showed comparable expression levels of maturation markers. Furthermore, we demonstrated that engineered cardiac tissues matured on CNT-GelMA have increased functionality through integrin-mediated mechanotransduction (via YAP/TAZ) in contrast to cardiomyocytes cultured on rGO-GelMA.

8.
J Pak Med Assoc ; 69(8): 1119-1123, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31431764

RESUMO

OBJECTIVE: To share the experience of a minimally invasive technique in the implantation of a dual chamber permanent pacemaker in paediatric population. METHODS: The retrospective study was conducted at Aga Khan University Hospital, Karachi, and comprised data of patients aged up to 16 years who underwent epicardial dual chamber permanent pacemaker insertion via xiphisternal incision between April 2011 and August 2016. Demographic data included age, weight and gender of the patient. Indications for pacemaker insertion, electrocardiography findings, concomitant cardiac procedures and procedural complications were reviewed. Pacemaker thresholds and impedance at the time of implantation and throughout the course of follow-up were extracted from the clinical data. RESULTS: Of the 10 patients, 5(50%) were males and 5(50%)were females. The overall mean age was 3.4}3.8 years (range: 1 month - 13 years). The mean weight at the time of operation was 11.4}6.8 kg (range: 4.3-27kg). Indications for permanent pacemaker insertion included postoperative advanced or complete atrioventricular block in 7(70%) and complete congenital heart block in 3(30%). There was no reported morbidity. CONCLUSIONS: Dual chamber permanent pacemaker insertion via xiphisternal incision was found to be of benefit to the patients and the surgeons alike.


Assuntos
Bloqueio Atrioventricular/terapia , Estimulação Cardíaca Artificial , Bloqueio Cardíaco/congênito , Procedimentos Cirúrgicos Minimamente Invasivos/métodos , Marca-Passo Artificial , Implantação de Prótese/métodos , Adolescente , Criança , Pré-Escolar , Feminino , Bloqueio Cardíaco/terapia , Humanos , Lactente , Recém-Nascido , Masculino
9.
Ann Card Anaesth ; 22(3): 260-264, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31274486

RESUMO

Background: Diabetes is not uncommon in patients requiring cardiac surgery. These patients have a higher incidence of morbidity and mortality. Subsequently, diabetes represents a major medico-economic problem in both developed and developing countries. This study was designed to observe the association between glycemic control and outcome of patients after open heart surgery in adult population. Materials and Methods: Data was collected retrospectively in all patients who underwent open cardiac surgery (coronary artery bypass grafting, valve, or bypass grafting with valve surgery) and survived 72 hours postoperatively and had diabetes. The study was conducted from January 2015 to December 2016. Results: Of the 129 patients included in the study, male dominated 101 (78.3%). Most frequent surgery was coronary artery bypass grafting (CABG) 123 (95.3%), CABG plus aortic valve replacement 4 (3.1%), and CABG plus mitral valve replacement 2 (1.6%). Considering diabetes, only 3 (2.3%) were on diet control, 112 (86.8%) on oral hypoglycemic agents (OHA), whereas 9 (7%) had control on both insulin and OHA. Only 5 (3.9%) had type I diabetes. The mean fasting blood sugar (FBS) was 154.58 g/dl, and the mean duration of diabetic mellitus was observed 12.32 years. Microvascular and macrovascular complications were 26/129 (20.16%) and 17/129 (13.17%), respectively. Total 75 (58.1%) patients did not require insulin and 54 (41.9%) were treated with insulin intraoperatively to keep the blood glucose level less than 200 g/dl. Cardiac arrhythmias were frequent in the insulin group (P < 0.05), which was also associated with increased stay in the cardiac intensive care unit. Conclusion: Inadequate glycemic control during open cardiac surgery can possibly lead to increased perioperative morbidity and mortality and with decreased long-term survival and recurrent ischemic events. Therefore, aiming for blood glucose levels around 140 mg/dl appears reasonable. Further studies are required to define specific glucose ranges for a clearer definition of recommended blood glucose goals in postoperative cardiac patients for the best outcomes in patients with diabetes mellitus.

10.
Front Oncol ; 9: 457, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31214502

RESUMO

An international group of 22 liver cancer experts from 18 institutions met in Miami, Florida to discuss the optimal utilization of proton beam therapy (PBT) for primary and metastatic liver cancer. There was consensus that PBT may be preferred for liver cancer patients expected to have a suboptimal therapeutic ratio from XRT, but that PBT should not be preferred for all patients. Various clinical scenarios demonstrating appropriateness of PBT vs. XRT were reviewed.

11.
J Cell Biochem ; 120(1): 182-191, 2019 01.
Artigo em Inglês | MEDLINE | ID: mdl-30230586

RESUMO

Fibroadenoma is the most common type of benign breast tumor, accounting for 90% of benign lesions in India. Somatic mutations in the mediator complex subunit 12 (MED12) gene play a critical role in fibroepithelial tumorigenesis. The current study evaluated the hotspot region encompassing exon 2 of the MED12 gene, in benign and malignant breast tumor tissue from women who presented for breast lump evaluation. A total of 100 (80 fibroadenoma and 20 breast cancer) samples were analyzed by polymerase chain reaction-Sanger sequencing. Sequence variant analysis showed that 68.75% of nucleotide changes were found in exon 2 and the remaining in the adjacent intron 1. Codon 44 was implicated as a hotspot mutation in benign tumors, and 86.36% of the identified mutations involved this codon. An in silico functional analysis of missense mutations using consensus scoring sorting intolerant from tolerant (SIFT), SIFT seq, Polyphen2, Mutation Assessor, SIFT transFIC, Polyphen2 transFIC, Mutation Assesor transFIC, I-Mutant, DUET, PON-PS, SNAP2, and protein variation effect analyzer] revealed that apart from variants involving codon 44 (G44S; G44H), others like V41A and E55D were also predicted to be deleterious. Most of the missense mutations appeared in the loop region of the MED12 protein, which is expected to affect its functional interaction with cyclin C-CDK8/CDK19, causing loss of mediator-associated cyclin depended kinase (CDK) activity. These results suggest a key role of MED12 somatic variations in the pathogenesis of fibroadenoma. For the first time, it was demonstrated that MED12 sequence variations are present in benign breast tumors in the south Indian population.


Assuntos
Neoplasias da Mama/genética , Éxons/genética , Fibroadenoma/genética , Complexo Mediador/química , Complexo Mediador/genética , Mutação de Sentido Incorreto , Adolescente , Adulto , Idoso , Sequência de Bases/genética , Criança , Códon/genética , Simulação por Computador , Ciclina C/metabolismo , Quinase 8 Dependente de Ciclina/metabolismo , Quinases Ciclina-Dependentes/metabolismo , Feminino , Humanos , Índia , Íntrons/genética , Aprendizado de Máquina , Pessoa de Meia-Idade , Fenótipo , Polimorfismo Genético , Estrutura Secundária de Proteína , Adulto Jovem
12.
Asian Cardiovasc Thorac Ann ; 27(1): 52-54, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-29860896

RESUMO

Chondrosarcoma is a cancer of cartilage cells, and despite being a common primary bone tumor, tracheal chondrosarcoma is rare with only 18 cases reported in the literature prior to mid-2016. A 60-year-old gentleman presented with progressively increasing cough, severe stridor, and production of phlegm for approximately 2 years. On admission to our tertiary care hospital, he developed complete obstructive apnea within an hour, and was intubated. A tracheal biopsy was performed, followed by resection. Histopathology confirmed chondrosarcoma of the trachea. The patient tolerated the procedure very well and is currently symptom-free on follow-up, with no signs of recurrence.


Assuntos
Condrossarcoma/cirurgia , Neoplasias da Traqueia/cirurgia , Obstrução das Vias Respiratórias/etiologia , Biópsia , Condrossarcoma/complicações , Condrossarcoma/diagnóstico , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias da Traqueia/complicações , Neoplasias da Traqueia/diagnóstico , Estenose Traqueal/etiologia , Resultado do Tratamento
13.
Asian Cardiovasc Thorac Ann ; 27(1): 36-38, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-28457174

RESUMO

In reoperation for an ascending aortic pseudoaneurysm eroding through the sternum, a left ventricular vent allows careful unhurried sternal division under deep hypothermic circulatory arrest. We repaired ascending aortic pseudoaneurysms in 2 patients who had undergone aortic valve implantation 6 and 21 months earlier. A minithoracotomy was made in the left 5th intercostal space, and a vent was placed in the left ventricular apex. Repair was accomplished with a bovine pericardial patch reinforced with a Teflon felt strip. Both patients made an uneventful recovery with good functional status at discharge at the 8- and 18-month follow-up.


Assuntos
Infecções por Acinetobacter/cirurgia , Falso Aneurisma/cirurgia , Aneurisma Infectado/cirurgia , Aneurisma Aórtico/cirurgia , Valva Aórtica/cirurgia , Implante de Prótese de Valva Cardíaca/efeitos adversos , Pericárdio/transplante , Esterno/cirurgia , Toracotomia , Procedimentos Cirúrgicos Vasculares/métodos , Infecções por Acinetobacter/diagnóstico por imagem , Infecções por Acinetobacter/microbiologia , Adulto , Idoso , Falso Aneurisma/diagnóstico por imagem , Falso Aneurisma/microbiologia , Aneurisma Infectado/diagnóstico por imagem , Aneurisma Infectado/microbiologia , Animais , Aneurisma Aórtico/diagnóstico por imagem , Aneurisma Aórtico/microbiologia , Aortografia/métodos , Bovinos , Parada Circulatória Induzida por Hipotermia Profunda , Angiografia por Tomografia Computadorizada , Feminino , Xenoenxertos , Humanos , Masculino , Esterno/diagnóstico por imagem , Esterno/patologia , Resultado do Tratamento
14.
JAMA Cardiol ; 4(1): 71-80, 2019 01 01.
Artigo em Inglês | MEDLINE | ID: mdl-30516815

RESUMO

Importance: Although several studies have reported data on surgical aortic valve durability, variability in study methodologies and definitions as well as inadequate follow-up make the interpretation of data from these studies difficult to interpret. Objective: To review available data on structural valve deterioration (SVD) of surgical bioprosthetic aortic valves by examining the published literature as well as data reported to the US Food and Drug Administration (FDA). Evidence Review: A systematic review using Preferred Reporting Items for Systematic Review and Meta-Analysis reporting guidelines to obtain all available data from preexisting literature on the actuarial freedom from SVD and outcomes of SVD. Data were collected from database inception to November 2016. Additionally, data reported to the FDA were obtained. Findings: In total, 167 studies and 12 FDA reports including 101 650 patients and 17 different valve types were analyzed. There were 11 different definitions of SVD used in the studies. Core laboratory data were available for 11 studies. Mean follow-up ranged from less than 1 year to 14 years. Kaplan-Meier estimates were reported for up to 30 years of follow-up, with 0% to 37% of patients remaining at risk at maximum follow-up. Food and Drug Administration-reported data are similarly variable in duration (mean follow-up range, 1.2 to 7 years) and completeness of follow-up, with final follow-up of 0.1% to 95%. Conclusions and Relevance: There is considerable variability in reporting SVD of surgical aortic valves, with different definitions and inadequate long-term systematically collected core laboratory data. Rigorously collected long-term data with standardized definitions for surgical valves are needed to provide a benchmark for the durability of rapidly evolving transcatheter valves.


Assuntos
Valva Aórtica/cirurgia , Falha de Prótese/tendências , Instrumentos Cirúrgicos/estatística & dados numéricos , Adulto , Idoso , Idoso de 80 Anos ou mais , Bioprótese/tendências , Seguimentos , Humanos , Metanálise como Assunto , Pessoa de Meia-Idade , Instrumentos Cirúrgicos/tendências , Estados Unidos/epidemiologia , United States Food and Drug Administration
15.
Artigo em Inglês | MEDLINE | ID: mdl-31905999

RESUMO

Algorithms for measuring semantic similarity between Gene Ontology (GO) terms has become a popular area of research in bioinformatics as it can help to detect functional associations between genes and potential impact to the health and well-being of humans, animals, and plants. While the focus of the research is on the design and improvement of GO semantic similarity algorithms, there is still a need for implementation of such algorithms before they can be used to solve actual biological problems. This can be challenging given that the potential users usually come from a biology background and they are not programmers. A number of implementations exist for some well-established algorithms but these implementations are not generic enough to support any algorithm other than the ones they are designed for. The aim of this paper is to shift the focus away from implementation, allowing researchers to focus on algorithm's design and execution rather than implementation. This is achieved by an implementation approach capable of understanding and executing user defined GO semantic similarity algorithms. Questions and answers were used for the definition of the user defined algorithm. Additionally, this approach understands any direct acyclic digraph in an Open Biomedical Ontologies (OBO)-like format and its annotations. On the other hand, software developers of similar applications can also benefit by using this as a template for their applications.


Assuntos
Algoritmos , Ontologia Genética , Semântica , Animais , Biologia Computacional , Humanos , Software
16.
Med Phys ; 2018 Jul 14.
Artigo em Inglês | MEDLINE | ID: mdl-30007067

RESUMO

PURPOSE: Hypofractionated radiotherapy of prostate cancer is gaining clinical acceptance given its potential increase in therapeutic ratio and evidence for noninferiority and lack of added late toxicities compared to conventional fractionation. However, concerns have been raised that smaller number of fractions might lead to larger dosimetric influence by interfractional motion. We aim to compare the effect of these variations on hypofractionated pencil beam scanning (PBS) proton therapy and volumetric modulated arc therapy (VMAT) for localized prostate cancer. METHODS: Weekly CT images were acquired for 6 patients participating in a randomized clinical trial. PBS plans featuring bilateral (BL) and a combination of lateral and anterior-oblique beams (AOL), and VMAT plans were created. All patients were treated to a conventional 79.2 Gy total dose in 44 fractions. For this study, hypofractionated dose to the prostate gland was 51.6 Gy in 12 fractions or 36.25 Gy in 5 fractions, and 32.8, and 23.1 Gy to proximal seminal vesicles, respectively. Patients were simulated with endorectal balloons to aid gland immobilization. Three fiducial markers were implanted for setup guidance. All plans were recomputed on the weekly CT images after aligning with the simulation CT. The entire set of 9 CT images was used for dose recalculation for 12-fraction and only 5 used for the 5-fraction case. Adaptive range adjustments were applied to anterior-oblique beams assuming clinical availability of in vivo range verification. Fractional doses were summed using deformable dose accumulation to approximate the delivered dose. Biologically equivalent dose to 2 Gy(EQD2) was calculated assuming α/ß of 1.5 Gy for prostate and 3 Gy for bladder and rectum. RESULTS: The median delivered prostate D98 was 0.13/0.14/0.13 Gy(EQD2) smaller than planned for PBS-BL, 0.13/0.27/0.17 Gy(EQD2) for PBS-AOL and 0.59/0.66/0.59 Gy(EQD2) for VMAT, for 44/12/5 fractions, respectively. The largest D98 reduction was 1.5 and 3.5 Gy(EQD2) for CTV1 and CTV2, respectively. Target dose degradation was comparable for all fractionation schemes within each modality. The maximum increase in rectum D2 was 0.98 Gy(EQD2) for a 5-fraction PBS case. CONCLUSIONS: The robustness of PBS and VMAT were comparable for all patients for the studied fractionations. The delivered target dose generally remained within clinical tolerance and the deviations were relatively minor for both fractionation schemes. The delivered OAR dose stayed in compliance with the RTOG hypofractionation constraints for all cases.

17.
J Coll Physicians Surg Pak ; 28(6): 479-481, 2018 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-29848429

RESUMO

Ultrasound-guided central venous cannulation is now considered as the standard of care, and this has largely replaced blind central venous cannulation using anatomical landmarks. We are reporting a case of inadvertent placement of central venous catheter in the right common carotid artery with the use of ultrasound guidance during emergency surgery for the total correction of Tetralogy of Fallot (ToF). This patient luckily had a favourable outcome despite this inadvertent catheter placement which was not recognised even after completion of surgery .The patient also received drug infusions of inotropes and vasopressors through this malplaced central line into the aorta. The possible mechanism, consequences, prevention and management of this inadvertent cannulation are discussed in this report.


Assuntos
Artérias Carótidas/diagnóstico por imagem , Lesões das Artérias Carótidas/etiologia , Cateterismo Venoso Central/efeitos adversos , Cateterismo Venoso Central/métodos , Cateteres Venosos Centrais , Erros Médicos/efeitos adversos , Tetralogia de Fallot/cirurgia , Ultrassonografia/métodos , Adolescente , Lesões das Artérias Carótidas/diagnóstico , Humanos , Masculino , Resultado do Tratamento , Ultrassonografia de Intervenção
18.
Ann Clin Psychiatry ; 30(2): 113-121, 2018 05.
Artigo em Inglês | MEDLINE | ID: mdl-29697712

RESUMO

BACKGROUND: Traumatic experiences can cause ethical conflicts. "Moral injury" (MI) has been used to describe this emotional/cognitive state, and could contribute to the development of posttraumatic stress disorder (PTSD) or block its recovery. We examine the relationship between MI and PTSD, and the impact of religious involvement (RI) on that relationship. METHODS: We conducted a study of 120 veterans enrolled at the Charlie Norwood VA Medical Center in Augusta, Georgia. Standard measures of PTSD symptoms, MI, and RI were administered. Regression models were used to examine correlates of PTSD symptoms and the moderating or mediating effects of RI. RESULTS: A strong relationship was found between MI and PTSD symptoms (r = 0.54, P ≤ .0001), and between MI and RI (r = -.41, P ≤ .0001), but only a weak relationship was found between RI and PTSD symptoms (r = -.17, P = .058). RI did not mediate or moderate the relationship between MI and PTSD symptoms in the overall sample. However, among non-Middle Eastern war theater veterans, a significant buffering effect of religiosity was found. CONCLUSIONS: MI has a strong positive relationship with PTSD symptoms and an inverse relationship with RI. RI did not mediate or moderate the relationship between MI and PTSD in the overall sample, but it moderated this relationship in non-Middle Eastern war theater veterans.


Assuntos
Religião , Transtornos de Estresse Pós-Traumáticos/diagnóstico , Veteranos/psicologia , Feminino , Hospitais de Veteranos , Humanos , Masculino , Pessoa de Meia-Idade , Transtornos de Estresse Pós-Traumáticos/psicologia , Inquéritos e Questionários , Estados Unidos , Veteranos/estatística & dados numéricos
19.
J Biomed Nanotechnol ; 14(3): 553-563, 2018 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-29663927

RESUMO

Side effects connected with chemotherapeutic agents used in cancer treatment has led to alternative modalities of combinatorial therapies in an attempt to reduce the drug dosage and associated risks. In the current study we evaluated the potential use of Ajwa Dates Extract (ADE), reported to have anti-cancer effects, as an adjuvant therapy in combination with 5-flurouracil (5FU) against the human-breast-adenocarcinoma cell line (MFC-7) in vitro. The effects of ADE alone and in combination with 5-FU were evaluated in terms of cell viability and cytotoxicity. For drug delivery purpose, we successfully encapsulated 5FU in both presence and absence of ADE through electrospinning together with poly lactic-co-glycolic acid (PLGA) in different combinations. Physicochemical properties of 5FU and ADE incorporated into PLGA nanofibers remained unaltered as confirmed by Fourier-Transform-Infrared (FTIR), Raman-spectroscopies and X-ray Diffraction (XRD) techniques. The morphological characterization of nanofibers was done using scanning electron microscopy (SEM) and atomic force microscopy (AFM). The surface roughness of PLGA and PLGA + ADE nanofibers increased by incorporation of 5FU. PLGA + ADE nanofibers were in hydrophilic range (<90°) while nanofibers prepared from both PLGA + 5FU and PLGA + 5FU + ADE combinations were in hydrophobic range (∼112°). The percentage inhibition of MCF-7 proliferation at 72 hrs showed an enhanced combinatorial anti-cancer effect of 5FU and ADE on the cells seeded on PLGA + 5FU + ADE mat (47% decrease) while PLGA + 5FU and PLGA + ADE demonstrated only 23% and 16% decrease respectively as compared to controls. The hydrophobicity induced by 5FU can further be investigated to get improved cellular adherence and efficient controlled-drug-release.


Assuntos
Nanofibras , Glicóis , Humanos , Phoeniceae , Copolímero de Ácido Poliláctico e Ácido Poliglicólico
20.
J Ayub Med Coll Abbottabad ; 29(3): 486-488, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-29076689

RESUMO

Penetrating neck and chest injuries are a common form of occupational injuries. We hereby report a unique case in which a metallic rod had penetrated the left chest and neck of a plastic factory worker. The patient was vitally stable when he presented to Emergency Room. Chest X-ray was performed and the patient was rushed to the operating room. VATS (video assisted thoracoscopic surgery) and neck dissection was done for retrieval of the metallic rod. On table, endoscopy was also done to rule out injury to oesophagus. No injury to vital structures was found and the subsequent recovery was uneventful.


Assuntos
Corpos Estranhos/cirurgia , Lesões do Pescoço/cirurgia , Traumatismos Torácicos/cirurgia , Cirurgia Torácica Vídeoassistida , Ferimentos Penetrantes/cirurgia , Acidentes de Trabalho , Adulto , Corpos Estranhos/complicações , Humanos , Masculino , Lesões do Pescoço/etiologia , Traumatismos Torácicos/etiologia , Ferimentos Penetrantes/complicações
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