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1.
Braz. j. biol ; 84: e251197, 2024. tab, graf
Artigo em Inglês | LILACS, VETINDEX | ID: biblio-1350305

RESUMO

Abstract Birds are among the best bio-indicators, which can guide us to recognize some of the main conservation concerns in ecosystems. Anthropogenic impacts such as deforestation, habitat degradation, modification of landscapes, and decreased quality of habitats are major threats to bird diversity. The present study was designed to detect anthropogenic causative agents that act on waterbird diversity in Tarbella Dam, Indus River, Pakistan. Waterbird censuses were carried out from March 2019 to February 2020 in multiple areas around the dam. A total of 2990 waterbirds representing 63 species were recorded. We detected the highest waterbird richness and diversity at Pehure whereas the highest density was recorded at Kabbal. Human activity impacts seemed to be the main factor determining the waterbird communities as waterbirds were negatively correlated with the greatest anthropogenic impacts. Waterbirds seem to respond rapidly to human disturbance.


Resumo As aves estão entre os melhores bioindicadores, o que pode nos orientar a reconhecer algumas das principais preocupações de conservação dos ecossistemas. Impactos antrópicos como desmatamento, degradação de habitat, modificação de paisagens e diminuição da qualidade dos habitats são as principais ameaças à diversidade de aves. O presente estudo foi desenhado para detectar agentes causadores antropogênicos que atuam na diversidade de aves aquáticas na Represa de Tarbella, rio Indus, Paquistão. Censos de aves aquáticas foram realizados de março de 2019 a fevereiro de 2020 em várias áreas ao redor da barragem. Um total de 2.990 aves aquáticas representando 63 espécies foi registrado. Detectamos a maior riqueza e diversidade de aves aquáticas em Pehure, enquanto a maior densidade foi registrada em Kabbal. Os impactos da atividade humana parecem ser o principal fator determinante das comunidades de aves aquáticas, uma vez que as aves aquáticas foram negativamente correlacionadas com os maiores impactos antrópicos. As aves aquáticas parecem responder rapidamente às perturbações humanas.


Assuntos
Humanos , Ecossistema , Rios , Paquistão , Conservação dos Recursos Naturais
2.
Braz. j. biol ; 83: e249229, 2023. tab, graf
Artigo em Inglês | LILACS, VETINDEX | ID: biblio-1339374

RESUMO

Abstract Birds are very valuable indicators of species richness and endemic patterns in a specified ecosystem, which eventually help the scientist to measure the environmental degradation. The aim of present study was to know human knowledge and attitude toward urban birds in Faisalabad city, Pakistan. The study conducted in four consecutive months: November 2019 to February 2020. Population of birds was noted from eight residential towns of Faisalabad city, data were collected through questionnaire. Faisalabad has a reasonably large population of birds and present data show that, there is a significant difference between favorite bird of residential areas and institutions. The pigeon received the most likeness in bird population among residential area residents, while the myna received the least. The most popular bird in Faisalabad institutions was the sparrow, while the least popular bird was the common myna. Bird adaptation percentage of residential areas and institutional areas of Faisalabad was the highest for parrot and sparrow respectively. People in residential areas and institutions, on the other hand, adapted least to common myna. It is concluded that people of the study area like birds and offered food and high population of birds are present in study area.


Resumo Os pássaros são indicadores muito valiosos da riqueza de espécies e padrões endêmicos em um determinado ecossistema, o que acaba ajudando o cientista a medir a degradação ambiental. O objetivo do presente estudo foi conhecer o conhecimento humano e a atitude em relação às aves urbanas na cidade de Faisalabad, Paquistão. O estudo foi conduzido em quatro meses consecutivos: novembro de 2019 a fevereiro de 2020. A população de pássaros foi observada em oito cidades residenciais da cidade de Faisalabad, os dados foram coletados por meio de questionário. Faisalabad tem uma população razoavelmente grande de pássaros, e os dados atuais mostram que há uma diferença significativa entre as aves favoritas de áreas residenciais e instituições. O pombo recebeu mais semelhanças na população de pássaros entre os residentes de áreas residenciais, enquanto o myna recebeu menos. A ave mais popular nas instituições de Faisalabad era o pardal, enquanto a ave menos popular era o myna comum. A porcentagem de adaptação de pássaros em áreas residenciais e institucionais de Faisalabad foi a mais alta para papagaios e pardais, respectivamente. As pessoas em áreas residenciais e instituições, por outro lado, se adaptaram menos ao myna comum. Conclui-se que pessoas da área de estudo como pássaros e alimentos oferecidos e alta população de pássaros estão presentes na área de estudo.


Assuntos
Humanos , Animais , Aves , Ecossistema , Paquistão , Cidades , Biodiversidade
3.
Braz J Biol ; 84: e251197, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34852136

RESUMO

Birds are among the best bio-indicators, which can guide us to recognize some of the main conservation concerns in ecosystems. Anthropogenic impacts such as deforestation, habitat degradation, modification of landscapes, and decreased quality of habitats are major threats to bird diversity. The present study was designed to detect anthropogenic causative agents that act on waterbird diversity in Tarbella Dam, Indus River, Pakistan. Waterbird censuses were carried out from March 2019 to February 2020 in multiple areas around the dam. A total of 2990 waterbirds representing 63 species were recorded. We detected the highest waterbird richness and diversity at Pehure whereas the highest density was recorded at Kabbal. Human activity impacts seemed to be the main factor determining the waterbird communities as waterbirds were negatively correlated with the greatest anthropogenic impacts. Waterbirds seem to respond rapidly to human disturbance.


Assuntos
Ecossistema , Rios , Conservação dos Recursos Naturais , Humanos , Paquistão
4.
Braz J Biol ; 83: e249229, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34669801

RESUMO

Birds are very valuable indicators of species richness and endemic patterns in a specified ecosystem, which eventually help the scientist to measure the environmental degradation. The aim of present study was to know human knowledge and attitude toward urban birds in Faisalabad city, Pakistan. The study conducted in four consecutive months: November 2019 to February 2020. Population of birds was noted from eight residential towns of Faisalabad city, data were collected through questionnaire. Faisalabad has a reasonably large population of birds and present data show that, there is a significant difference between favorite bird of residential areas and institutions. The pigeon received the most likeness in bird population among residential area residents, while the myna received the least. The most popular bird in Faisalabad institutions was the sparrow, while the least popular bird was the common myna. Bird adaptation percentage of residential areas and institutional areas of Faisalabad was the highest for parrot and sparrow respectively. People in residential areas and institutions, on the other hand, adapted least to common myna. It is concluded that people of the study area like birds and offered food and high population of birds are present in study area.


Assuntos
Aves , Ecossistema , Animais , Biodiversidade , Cidades , Humanos , Paquistão
5.
Mymensingh Med J ; 27(2): 275-279, 2018 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-29769490

RESUMO

Eclampsia is a common problem in pregnancy in Bangladesh. It is a severe form of preeclampsia which affects 5 to 7% of pregnancies is a significant cause of maternal & neonatal morbidity & mortality. Pre-eclampsia when complicated with generalized tonic-clonic convulsions and/or coma is called eclampsia. The term eclampsia is derived from a Greek word, meaning "like a flash of lightening". It may occur quite abruptly, without any warning manifestations. Eclampsia is a major cause of maternal mortality & morbidity as well as foetal loss worldwide, particularly in the third world. Appropriate measures & effective treatment of eclamptic patient in proper time reduce maternal mortality & morbidity. The mainstay of treatment of eclampsia is delivery of the foetus. Two methods are usually applied for delivery of foetus in eclampsia i.e. vaginal delivery & caesarean delivery. This study was done in the department of Gynae & Obs and department of Anaesthesiology, Mymensingh Medical College Hospital from 1st January 2016 to 30th June 2016 to observe the incidence, complications (morbidity) & mortality of eclamptic patients & which method (vaginal delivery versus caesarean delivery by spinal anaesthesia) is safe, better for the eclamptic patients as well as foetal mortality. Successful vaginal delivery is dependant on complex interactions of three variables (3 P) that is power (uterine contraction), passenger (foetus) & passage (birth canal) but power is less effective in eclamptic patient than normal partuents. Vaginal delivery requires prolong times compared with cesarean delivery. Anaesthetic technique is also an important factor for maternal mortality & morbidity of caesarean delivery. Spinal anaesthesia is widely regarded as a reasonable anaesthetic option for caesarean delivery in eclamptic patients. Currently the safety of spinal anaesthesia is well established and it can provide better obstetrical outcome when chosen properly. In this observation caesarean delivery by spinal anesthesia is safer, less complications, less maternal & neonatal mortality than vaginal delivery in eclamptic patients.


Assuntos
Cesárea , Parto Obstétrico , Eclampsia , Raquianestesia , Bangladesh , Eclampsia/terapia , Feminino , Humanos , Gravidez
6.
Neth J Med ; 75(7): 307, 2017 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-28956790
7.
Mymensingh Med J ; 25(4): 615-619, 2016 10.
Artigo em Inglês | MEDLINE | ID: mdl-27941719

RESUMO

Benign prostatic hyperplasia and carcinoma of the prostate are the most common disorders of Bangladeshi male in recent years. Volume of the prostate is necessary to estimate the amount of BPH adenoma to determine the appropriate therapy or to select the surgical approach. Transurethral resection of prostate (TURP) is preferred for small glands and open prostatectomy for larger ones. Decrease in prostatic mass after hormonal manipulation or radiation therapy can be used as an indicator of therapeutic efficacy. The effect of prostate volume on biopsy outcome was assessed and was noted that there was an inverse relationship in between size of the gland and prostate cancer. A cross sectional descriptive study was conducted in Department of Anatomy, Mymensingh Medical College, Mymensingh, Bangladesh to find out the difference in volume of the prostate gland of Bangladeshi people in relation to age. The present study was performed on 67 postmortem human prostate gland collected from the morgue in the Department of Forensic Medicine, Mymensingh Medical College by non random purposive sampling technique. The specimens were collected from Bangladeshi cadaver of age ranging from 10 to 80 years. All the specimens were grouped into three categories: Group A (upto 18 years), Group B (19 to 45 years) and Group C (above 45 years) according to age. Dissection was performed according to standard autopsy techniques. The volume of the prostate gland were measured and recorded. The mean volume of the prostate gland was 13.75ml in Group A, 24.44ml in Group B and 29.72ml in Group C. Variance analysis shows that mean differences of volume of the prostate were highly significant among all age groups. The volume of prostate gland was found to be increased with increasing age. For statistical analysis, differences between age groups were analyzed by using students unpaired 't' test. The present study will help to increase the information pool on the volume of prostate gland of Bangladeshi people.


Assuntos
Próstata , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Bangladesh , Cadáver , Criança , Estudos Transversais , Humanos , Masculino , Pessoa de Meia-Idade , Hiperplasia Prostática , Ressecção Transuretral da Próstata , Adulto Jovem
8.
Tsitol Genet ; 50(2): 13-20, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27281920

RESUMO

The present study was designed considering the importance of grain quality traits, genetic diversity and marker-trait association analysis in wheat. A significant amount of genetic diversity was found for various seed traits though the genotypes included in the study were found structured. The extent of polymorphism was high with a range of 2-13 alleles and average of 6.5 alleles per locus. Population structure was detected with 30 unlinked SSRs that divided the population of 92 genotypes in three sub-populations. Extensive LD extent was found on chromosome 1B with 42 SSRs specific for 1B chromosome. Marker-trait associations were determined using mixed linear model, where, population structure and kinship calculated on the basis of unlinked markers were covariated with 1B specific markers and traits data. Eight QTLs for five traits including protein, gluten contents, test weight bread and chapati making quality. Protein content, test weight, bread quality and Glu-B1 were found significantly associated with primers WMC419 (32 cM); WMC128 (30 cM), WMC419 (32 cM); WMC818 (17 cM) and WMC416 (44 cM), respectively.


Assuntos
Cromossomos de Plantas/genética , Locos de Características Quantitativas , Sementes/genética , Triticum/genética , Alelos , Análise de Variância , Mapeamento Cromossômico , Genótipo , Polimorfismo Genético , Polimorfismo de Fragmento de Restrição , Sementes/anatomia & histologia , Sementes/crescimento & desenvolvimento , Triticum/anatomia & histologia , Triticum/crescimento & desenvolvimento
9.
Mymensingh Med J ; 24(4): 859-63, 2015 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-26620032

RESUMO

People with rare hypertrichosis syndromes became crowd-drawing money-making phenomena in many 19th century sideshow acts. These individuals have been referred to as dog-men, hair-men, and werewolves. In 1993, Baumister et al. described congenital hypertrichosis lanuginose or Ambras syndrome: a distinct form of congenital hypertrichosis characterized by excessive hair growth over the body and face associated with facial and occasional dental anomalies. Much is not known about this syndrome since fewer than 50 cases have been documented worldwide. In this case report, a nine year old girl presented with excessive hair growth throughout her body that was denser along her midline. Furthermore, her face displayed the typical dysmorphic features characteristic of Ambras syndrome: a round tip nose, thickened nasal cartilage, antiverted nares, prominent philtrum with deep groove, and a trapezoid mouth. Oral examination revealed normal oral mucosa with completely missing and unerupted decidious and permanent teeth. Panoramic radiographs confirmed unerupted deciduous teeth. Previous case reports have mentioned the presence of occasional dental anomalies such as retarded first and second dentition and absence of some teeth. However, this is the first reported case of Ambras syndrome presenting with complete anodontia. Prior cytogenetic studies performed on persons with Ambras syndrome have implicated a balanced pericentric inversion of chromosome 8. However, it is likely that dental anomalies are likely a result of a different genetic rearrangement. Further studies are needed to explore the cause of this rare phenotype of Ambras syndrome with complete unerupted dentition.


Assuntos
Hipertricose/congênito , Criança , Feminino , Humanos , Hipertricose/patologia , Hipertricose/reabilitação , Radiografia Panorâmica
10.
JBR-BTR ; 98(3): 127-128, 2015 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-30394442

RESUMO

BACKGROUND: A 32-year-old lady of Asian descent presented with pain and severe stiffness of the back and hips progressively worsening over several years. She was diabetic but had no past medical history of rickets or renal disease. On examination she was of short stature with marked thoracic kyphosis and flattening of the lumbar spine. Spinal movements were globally restricted and the hips demonstrated a fixed flexion deformity. Her initial diagnosis had been ankylosing spondylitis until she had a MRI scan. Plain radiographs and further MRI of the hips were also performed. Subsequent laboratory tests revealed she was vitamin D deficient, normocalcemic with raised parathyroid hormone (PTH) and alkaline phosphatase.

12.
Indian J Cancer ; 51(2): 133-7, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-25104194

RESUMO

BACKGROUND: An assessment of cancer incidence in population is required for prevention, early diagnosis, treatment and resource allocation. This will also guide in the formation of facilities for diagnosis, treatment, rehabilitation and follow-up for these patients. The demographic trend of cancer will help to identify common types and etiological factors. Efforts at clinical, research and administrative levels are needed to overcome this problem. SETTINGS AND DESIGN: Present retro prospective study was conducted in regional cancer center of a tertiary care hospital. MATERIALS AND METHODS: After permission from ethics committee, a retro prospective study of 1 year duration was undertaken to study the profile of cancer patients and to compare it with other cancer registries in India. STATISTICAL ANALYSIS: Pearson's Chi-square test and simple linear regression were used. Statistical Package for the Social Sciences version-16 (University of Bristol information services (www.bristol.ac.uk/is/learning/resources) was used. RESULTS: The overall incidence of cancer in Kashmir is on the increase and common sites of cancer are esophagus and gastroesophageal (GE) junction, lung, stomach, colorectal, lymphomas, skin, laryngopharynx, acute leukemias, prostate and brain in males.In females common sites are breast, esophagus and GE junction, ovary, colorectal, stomach, lung, gallbladder, lymphomas, acute leukemias and brain. CONCLUSION: Cancers of esophagus, stomach and lungs have a high incidence both in men and women in Kashmir. Future studies on sources and types of environmental pollution and exposures in relation to these cancers may improve our understanding of risk factors held responsible for causation of these malignancies in this region. This will help in the allocation of available resources for prevention and treatment strategies.


Assuntos
Neoplasias/epidemiologia , Distribuição por Idade , Feminino , Humanos , Incidência , Índia/epidemiologia , Masculino , Sistema de Registros , Distribuição por Sexo
13.
Vet Rec ; 173(5): 117, 2013 Aug 03.
Artigo em Inglês | MEDLINE | ID: mdl-23832268

RESUMO

The infection status of cattle for bovine tuberculosis (bTB) was determined by real-time PCR, comparing the levels of IFN-γ mRNA in blood cultures stimulated with either bovine or avian tuberculin with non-stimulated control (phosphate buffer saline, PBS) blood culture. Totally, 137 cattle were tested to validate the assay, in which 54 were IFN-γ real-time quantitative PCR (RT-qPCR) positive, while the remaining 83 were found negative. Meanwhile, the IFN-γ ELISA test was carried out using the Bovigam IFN-γ detection ELISA kit and these results were used as a standard. The results of the single intradermal tuberculin tests (SIDT) and IFN-γ RT-qPCR tests were compared and revealed that the RT-qPCR correlated better with the ELISA and its accuracy was higher than SIDT. This indicates the RT-qPCR is a useful diagnostic method for bTB in cattle. However, several limitations remain for our approach, such as lack of a TB lesions or postmortem test results as a gold standard. Further improvements should be made in the future to increase accuracy of diagnosis of bTB in cattle.


Assuntos
Interferon gama/sangue , RNA Mensageiro/sangue , Reação em Cadeia da Polimerase em Tempo Real/veterinária , Tuberculose Bovina/diagnóstico , Animais , Bovinos , Ensaio de Imunoadsorção Enzimática/veterinária , Testes Intradérmicos/veterinária , Reprodutibilidade dos Testes , Teste Tuberculínico/veterinária , Tuberculose Bovina/sangue
14.
East Mediterr Health J ; 19(2): 175-80, 2013 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-23516829

RESUMO

The diagnosis of diabetes mellitus by the available criteria is controversial and relies heavily on fasting glucose results. This cross-sectional study in 2010-2011 aimed to measure the frequency of impaired glucose tolerance and diabetes mellitus in 127 subjects having fasting blood glucose < 7.0 mmol/L and to measure the agreement between different standard diagnostic criteria. Subjects presenting to a laboratory for analysis of fasting blood glucose for excluding diabetes mellitus underwent a 2-hour 75 g oral glucose challenge. A total of 40.6% of subjects with fasting blood glucose from 5.6-6.0 mmol/L had abnormal glucose regulation on the basis ofthe gold standard glucose challenge. Agreement between American Diabetes Association and World Health Organization diagnostic criteria was only fair (kappa = 0.32). Abnormalities of glucose metabolism including impaired glucose tolerance and diabetes mellitus can exist at fasting blood glucose results < 6.1 mmol/L (110 mg/dL).


Assuntos
Glicemia , Diabetes Mellitus Tipo 2/diagnóstico , Diabetes Mellitus Tipo 2/epidemiologia , Intolerância à Glucose/diagnóstico , Intolerância à Glucose/epidemiologia , Teste de Tolerância a Glucose/métodos , Adulto , Comorbidade , Estudos Transversais , Diabetes Mellitus Tipo 2/sangue , Jejum , Feminino , Intolerância à Glucose/sangue , Teste de Tolerância a Glucose/estatística & dados numéricos , Humanos , Incidência , Masculino , Paquistão/epidemiologia , Fatores de Risco , Organização Mundial da Saúde
15.
Clin Radiol ; 68(5): e239-44, 2013 May.
Artigo em Inglês | MEDLINE | ID: mdl-23261034

RESUMO

AIM: To measure radiologist workloads in a UK radiology department using relative value units (RVUs), and compared these data to current international standards from Australia and Ireland. MATERIALS AND METHODS: Data on reporting throughput was gathered for 13.5 whole-time equivalent (WTE) consultants at the DGHs of East Lancashire Hospitals Trust (ELHT) between April 2010 to March 2011. RVUs were assigned to the reported imaging studies to create a crude RVU/WTE score. This was compared to benchmarks from Australia and results from a similar study in Ireland. Time spent on teaching, multidisciplinary teams, and administration was factored in to create a net RVU/WTE score, more accurately assessing workload. RESULTS: Radiologists in ELHT reported 110,315 imaging studies, producing a total of 649,617 RVUs. Crude reporting workloads were 48,119.78 RVUs/WTE, and net workloads were 83,674.00 RVUs/WTE (with consultants spending 42.49% of their time on non-reporting commitments). These crude and net workloads are far above the Australian maximum reporting benchmark of 45,000 RVUs. CONCLUSION: The workload is much higher than international benchmarks, indicating high-quality service and excellent value for money, but also highlights understaffing. Foreign RVU systems do not accurately reflect current UK practices and a UK-specific RVU system should be developed to assess staffing and analyse performance.


Assuntos
Centros Médicos Acadêmicos/estatística & dados numéricos , Benchmarking/estatística & dados numéricos , Consultores/estatística & dados numéricos , Serviço Hospitalar de Radiologia/estatística & dados numéricos , Radiologia , Carga de Trabalho/estatística & dados numéricos , Austrália , Benchmarking/métodos , Diagnóstico por Imagem/estatística & dados numéricos , Eficiência Organizacional/estatística & dados numéricos , Humanos , Irlanda , Escalas de Valor Relativo , Reino Unido , Recursos Humanos
18.
Br J Hosp Med (Lond) ; 72(7): M109-11, 2011 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-21841603

RESUMO

Thoracolumbar vertebral fractures typically involve high velocity trauma such as road traffic collisions, falls from height or sporting accidents, and are a major cause of spinal injury. Plain radiographs remain the first-line investigation, but interpretation can be difficult because of the variety of injury patterns and sometimes subtle radiographic signs. This article reviews the normal anatomy, systematic interpretation of thoracic and lumbar radiographs and typical injury patterns.


Assuntos
Vértebras Lombares/lesões , Traumatismos da Coluna Vertebral/diagnóstico por imagem , Vértebras Torácicas/lesões , Doença Aguda , Humanos , Radiografia
19.
Genet Mol Res ; 10(2): 1156-67, 2011 Jun 14.
Artigo em Inglês | MEDLINE | ID: mdl-21710467

RESUMO

Cotton (Gossypium hirsutum) is an important cash crop, but high temperature during its growing season is one of the major factors that limit its productivity. This problem compels plant breeders to breed for heat tolerance, which can help to overcome this challenge. It is very important to make a comprehensive screening of heat-tolerant genotypes so that only the best are chosen. Here we report the combined use of several techniques that can help breeders to screen their germplasm. Twelve cultivated cotton genotypes were evaluated for thermotolerance, using assays that included electrolyte leakage, chlorophyll accumulation and protein profiling, as well as RAPDs to assess genetic diversity. Two genotypes (B-557 and NIAB-78) showed tolerant behavior in three thermotolerance assays. RAPD analysis results showed maximum similarity in a range of 86.7-66.7% between the genotypes MNH-554 and CIM-443. We conclude that combined use should be made of relative electrolyte leakage, chlorophyll stability and differential display with SDS-PAGE to aid in screening for stress tolerance. RAPD-based diversity analysis will further help to improve the efficiency of breeding programs.


Assuntos
Adaptação Fisiológica , Gossypium/fisiologia , Temperatura , Genes de Plantas , Gossypium/genética , Técnica de Amplificação ao Acaso de DNA Polimórfico
20.
Life Sci ; 88(13-14): 565-71, 2011 Mar 28.
Artigo em Inglês | MEDLINE | ID: mdl-21284948

RESUMO

Androgens are involved in the development of several tissues, including prostate, skeletal muscle, bone marrow, hair follicles, and brain. Most of the biological effects of the androgens are mediated through an intracellular transcription factor, the androgen receptor (AR) at the level of gene regulation. Several types of mutations in the AR gene have been linked to endocrine dysfunctions. The expansion of CAG codon repeat, coding for a polyglutamine (PolyQ) tract in the N-terminal domain is one such mutation. The polyQ chain length impacts AR's ability to interact with critical coregulators, which in turn modulates its transcriptional efficacy. Pathologic manifestations of variations in polyQ chain length have been associated with prostate cancer susceptibility, and the Spinal and Bulbar Muscular Atrophy (SBMA), a neurodegenerative disease. In this review article, we discuss multiple aspects of the role of polyQ chain length in the actions of the AR, their importance in prostate cancer development and progression, and SBMA with an aim to understand the underlying mechanisms involved in these diseases, which can be targeted for future therapeutic approaches.


Assuntos
Atrofia Bulboespinal Ligada ao X/genética , Peptídeos/genética , Polimorfismo Genético , Neoplasias da Próstata/genética , Receptores Androgênicos/genética , Expansão das Repetições de Trinucleotídeos , Atrofia Bulboespinal Ligada ao X/metabolismo , Atrofia Bulboespinal Ligada ao X/patologia , Predisposição Genética para Doença , Humanos , Masculino , Peptídeos/metabolismo , Neoplasias da Próstata/metabolismo , Neoplasias da Próstata/patologia , Receptores Androgênicos/metabolismo
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